CN113662896A - Plant-derived skin-care whole-body lotion and preparation method and application thereof - Google Patents
Plant-derived skin-care whole-body lotion and preparation method and application thereof Download PDFInfo
- Publication number
- CN113662896A CN113662896A CN202111140935.6A CN202111140935A CN113662896A CN 113662896 A CN113662896 A CN 113662896A CN 202111140935 A CN202111140935 A CN 202111140935A CN 113662896 A CN113662896 A CN 113662896A
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- China
- Prior art keywords
- agent
- extract
- plant
- parts
- skin
- Prior art date
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- Granted
Links
- 239000006210 lotion Substances 0.000 title claims abstract description 55
- 238000002360 preparation method Methods 0.000 title abstract description 20
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 106
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 30
- 239000000419 plant extract Substances 0.000 claims abstract description 29
- 241000196324 Embryophyta Species 0.000 claims abstract description 23
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 19
- 239000004094 surface-active agent Substances 0.000 claims abstract description 17
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000002994 raw material Substances 0.000 claims abstract description 13
- 239000011732 tocopherol Substances 0.000 claims abstract description 13
- 235000010384 tocopherol Nutrition 0.000 claims abstract description 13
- 229960001295 tocopherol Drugs 0.000 claims abstract description 13
- 229930003799 tocopherol Natural products 0.000 claims abstract description 13
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims abstract description 13
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims abstract description 10
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 claims abstract description 10
- VFKZECOCJCGZQK-UHFFFAOYSA-M 3-hydroxypropyl(trimethyl)azanium;chloride Chemical compound [Cl-].C[N+](C)(C)CCCO VFKZECOCJCGZQK-UHFFFAOYSA-M 0.000 claims abstract description 10
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 claims abstract description 10
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 10
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 claims abstract description 10
- PNNNRSAQSRJVSB-BXKVDMCESA-N aldehydo-L-rhamnose Chemical compound C[C@H](O)[C@H](O)[C@@H](O)[C@@H](O)C=O PNNNRSAQSRJVSB-BXKVDMCESA-N 0.000 claims abstract description 10
- OQLKNTOKMBVBKV-UHFFFAOYSA-N hexamidine Chemical compound C1=CC(C(=N)N)=CC=C1OCCCCCCOC1=CC=C(C(N)=N)C=C1 OQLKNTOKMBVBKV-UHFFFAOYSA-N 0.000 claims abstract description 10
- 229960001915 hexamidine Drugs 0.000 claims abstract description 10
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims abstract description 10
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims abstract description 10
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims abstract description 10
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims abstract description 10
- SUMDYPCJJOFFON-UHFFFAOYSA-N isethionic acid Chemical class OCCS(O)(=O)=O SUMDYPCJJOFFON-UHFFFAOYSA-N 0.000 claims abstract description 10
- 229940041616 menthol Drugs 0.000 claims abstract description 10
- PHZLMBHDXVLRIX-UHFFFAOYSA-M potassium lactate Chemical compound [K+].CC(O)C([O-])=O PHZLMBHDXVLRIX-UHFFFAOYSA-M 0.000 claims abstract description 10
- 239000001521 potassium lactate Substances 0.000 claims abstract description 10
- 235000011085 potassium lactate Nutrition 0.000 claims abstract description 10
- 229960001304 potassium lactate Drugs 0.000 claims abstract description 10
- 239000011780 sodium chloride Substances 0.000 claims abstract description 10
- 230000002421 anti-septic effect Effects 0.000 claims abstract description 6
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims abstract description 6
- 229960004106 citric acid Drugs 0.000 claims abstract description 3
- 239000001384 succinic acid Substances 0.000 claims abstract description 3
- 230000009885 systemic effect Effects 0.000 claims abstract 11
- 239000000284 extract Substances 0.000 claims description 80
- 238000003756 stirring Methods 0.000 claims description 18
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- 238000010438 heat treatment Methods 0.000 claims description 7
- 239000003755 preservative agent Substances 0.000 claims description 7
- 230000002335 preservative effect Effects 0.000 claims description 7
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims description 7
- 244000247747 Coptis groenlandica Species 0.000 claims description 6
- 235000002991 Coptis groenlandica Nutrition 0.000 claims description 6
- WNLRTRBMVRJNCN-UHFFFAOYSA-L adipate(2-) Chemical compound [O-]C(=O)CCCCC([O-])=O WNLRTRBMVRJNCN-UHFFFAOYSA-L 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 6
- 229940057950 sodium laureth sulfate Drugs 0.000 claims description 6
- 229940102541 sodium trideceth sulfate Drugs 0.000 claims description 6
- SXHLENDCVBIJFO-UHFFFAOYSA-M sodium;2-[2-(2-dodecoxyethoxy)ethoxy]ethyl sulfate Chemical compound [Na+].CCCCCCCCCCCCOCCOCCOCCOS([O-])(=O)=O SXHLENDCVBIJFO-UHFFFAOYSA-M 0.000 claims description 6
- KLYDBHUQNXKACI-UHFFFAOYSA-M sodium;2-[2-(2-tridecoxyethoxy)ethoxy]ethyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCOCCOCCOCCOS([O-])(=O)=O KLYDBHUQNXKACI-UHFFFAOYSA-M 0.000 claims description 6
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 235000021513 Cinchona Nutrition 0.000 claims description 3
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- 239000009513 Coptidis rhizoma extract Substances 0.000 claims description 3
- 125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 3
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 2
- 239000005711 Benzoic acid Substances 0.000 claims description 2
- 241000195634 Dunaliella Species 0.000 claims description 2
- 244000184734 Pyrus japonica Species 0.000 claims description 2
- 235000010233 benzoic acid Nutrition 0.000 claims description 2
- 229960004365 benzoic acid Drugs 0.000 claims description 2
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims description 2
- 229960005323 phenoxyethanol Drugs 0.000 claims description 2
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 claims description 2
- 235000010199 sorbic acid Nutrition 0.000 claims description 2
- 239000004334 sorbic acid Substances 0.000 claims description 2
- 229940075582 sorbic acid Drugs 0.000 claims description 2
- 230000007794 irritation Effects 0.000 abstract description 19
- 230000001681 protective effect Effects 0.000 abstract description 2
- 244000007835 Cyamopsis tetragonoloba Species 0.000 abstract 1
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- ROSDSFDQCJNGOL-UHFFFAOYSA-N protonated dimethyl amine Natural products CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
- A61K8/9722—Chlorophycota or Chlorophyta [green algae], e.g. Chlorella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9755—Gymnosperms [Coniferophyta]
- A61K8/9761—Cupressaceae [Cypress family], e.g. juniper or cypress
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/81—Preparation or application process involves irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Mycology (AREA)
- Botany (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides plant-derived skin-care whole-body lotion and a preparation method and application thereof, relating to the technical field of skin care products, and the plant-derived skin-care whole-body lotion comprises the following raw materials: agent A, agent B, agent C and agent D; wherein, the agent A comprises a surfactant and water; the agent B comprises: cocamide MEA, tocopherol, and plant extracts; the agent C comprises one or more of guar hydroxypropyl trimethyl ammonium chloride, polyquaternium-10 and hydroxypropyl methyl cellulose; the agent D comprises: citric acid, menthol, hexamidine di (isethionate) salt, succinic acid monoglyceride, potassium lactate, L-rhamnose, sodium chloride, and an antiseptic. The systemic lotion reduces the irritation of related components to skin, ensures longer shelf life and product efficacy, and enhances the safety and protective performance of the lotion to the systemic skin.
Description
Technical Field
The invention relates to the technical field of skin care products, in particular to plant-derived skin health care whole body lotion and a preparation method and application thereof.
Background
Most of the lotion in the prior art is antibacterial lotion or therapeutic lotion, mainly aiming at gynecological patients or skin patients, but little and little health-care whole body lotion for non-gynecological patients and non-skin patients. In addition, most of the existing skin care lotion is prepared from purified chemical products, so that various chemical components are inevitably left, and further, the skin is damaged. Thus, it is common in the art to select the addition of natural ingredients to replace or reduce the addition of chemical components, such as plant extracts. The plant extract is obtained by taking plants as raw materials and extracting the raw materials by using a solvent or adopting a proper method according to application requirements, conceptual intersection exists between the plant extract and the Chinese herbal medicine extract, and the plant extract in China mainly comes from Chinese medicines. The literature: huangliuyun, Longzhike, Zhongzhou inspection, etc. 4 Chinese medicinal extracts have bacteriostasis and application in skin detergent [ J ] spice essence cosmetics 2020(4):36-40. the bacteriostasis of 4 Chinese medicinal extracts of Chinese gall, licorice, scutellaria and cortex dictamni on escherichia coli and staphylococcus aureus and the bacteriostasis of the compound extract after the compound extract is matched with the skin detergent are analyzed and researched. Meanwhile, the hand sanitizer and the shower gel with obvious antibacterial effect are obtained by adding the compound extract into a skin detergent. Patent CN201610166498.8 related to this document also protects the skin cleansing agent formulation. In addition, patent cn201210438387.x discloses a Chinese herbal medicine health-care lotion and a preparation method thereof, raw materials of the lotion mainly come from Chinese herbal medicines, such as ginseng, gastrodia elata, ganoderma lucidum, pseudo-ginseng, cordyceps sinensis, dendrobe, mesona chinensis benth, honeysuckle, dandelion, isatis root, mung bean, wild chrysanthemum flower, red peony root, buffalo horn, pawpaw, mulberry twig, acanthopanax bark, red coix seed, ginkgo leaf, clam shell, ligusticum wallichii, rumex japonicus and the like, are obtained by decoction and extraction, and mainly aim at social groups with poor mental status, easy fatigue and poor skin, and the invention mainly plays a role in regulating and treating the body by medicinal bath, and also mainly aims at carrying out research tests on people with poor mental/physical labor and mental status for a long time. But the skin condition of the subject was not much explored. The patent CN202010414376.2 discloses a plant-derived skin health-care lotion and a preparation method thereof, wherein the plant-derived skin health-care lotion comprises 76-79 parts by mass of an agent A, 15.6-17.7 parts by mass of an agent B, 0.55-1 part by mass of an agent C and 2.75-3 parts by mass of an agent D; the agent B consists of cocamide MEA, 2-sulfo-sodium methyl laurate and plant extract; the functional plant extract permeates into skin, regulates the skin to slow the skin shedding speed and skin itch, promotes skin blood circulation, removes skin grease, and improves the absorption of hair follicles to nutrient components. Meanwhile, the invention mainly researches the skin test condition of the health care lotion aiming at patients of different ages. However, the lotion only reflects the skin itching, dryness and desquamation before and after the lotion is used by a patient, has strong subjectivity, and meanwhile, part of raw materials, such as coco dimethyl ammonium hydroxypropyl hydrolyzed keratin, have certain irritation to the skin, eyes and the like, and is not suitable for some sensitive skin audience groups.
Aiming at the problems of health-care lotion deficiency, skin damage caused by chemical components and poor efficacy of related products in the lotion in the prior art, the lotion which takes plant extracts as main efficacy raw materials, reasonably replaces the chemical components and aims at whole body health care and has strong universality is imperative to be found.
Disclosure of Invention
Aiming at the problems in the prior art, the invention provides the plant-derived skin health care whole-body lotion and the preparation method and the application thereof, the whole-body lotion reduces the irritation of relevant components to skin by compounding the components, and enhances the safety and the protection of the lotion to the whole-body skin while ensuring longer quality guarantee time and product efficacy.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows:
the invention provides a plant-derived skin-care whole-body lotion, which comprises the following raw materials: agent A, agent B, agent C and agent D;
the agent A comprises a surfactant and water;
the agent B comprises: cocamide MEA, tocopherol, and plant extracts;
the agent C comprises one or more of guar hydroxypropyl trimethyl ammonium chloride, polyquaternium-10 and hydroxypropyl methyl cellulose;
the agent D comprises: citric acid, menthol, hexamidine di (isethionate) salt, succinic acid monoglyceride, potassium lactate, L-rhamnose, sodium chloride, and an antiseptic.
Further, the weight ratio of the agent A, the agent B, the agent C and the agent D is 70-75:16-18:1.2-1.5: 1.5-2.5. Preferably 72:17:1.2: 2.
Further, the weight ratio of the agent B to the agent D is 16-18: 2-3.
Preferably, the agent A comprises 14-16.8 parts of surfactant and 50-60 parts of water;
the agent B comprises: 1-2 parts of cocamide MEA, 0.05-0.1 part of tocopherol and 15-18 parts of plant extract;
the agent C comprises 0.3-0.6 part of guar hydroxypropyl trimethyl ammonium chloride, 0.2-0.25 part of polyquaternium-10 and 0.1-0.2 part of hydroxypropyl methyl cellulose;
the agent D comprises: 0.1-0.2 part of citric acid, 0.1-0.2 part of menthol, 0.1-0.2 part of hexamidine di (isethionic acid) salt, 0.2-0.5 part of monoglyceride succinate, 0.5-1 part of potassium lactate, 1-1.5 parts of L-rhamnose, 0.1-0.2 part of sodium chloride and 0.05-0.08 part of preservative.
Further preferably, the agent a comprises 15.8 parts surfactant and 55.6 parts water;
the agent B comprises: 1.8 parts cocamide MEA, 0.08 parts tocopherol and 16 parts plant extract;
the agent C comprises 0.5 part of guar hydroxypropyl trimethyl ammonium chloride, 0.2 part of polyquaternium-10 and 0.2 part of hydroxypropyl methyl cellulose;
the agent D comprises: 0.15 part of citric acid, 0.15 part of menthol, 0.15 part of hexamidine di (isethionic acid) salt, 0.3 part of monoglyceride succinate, 0.6 part of potassium lactate, 1.2 parts of L-rhamnose, 0.15 part of sodium chloride and 0.06 part of preservative.
Further, the plant extract comprises: one or more of radix Sophorae Flavescentis extract, cortex Dictamni Radicis extract, folium Platycladi extract, Saviae Miltiorrhizae radix extract, cortex Cinchonae extract, Coptidis rhizoma extract, rhizoma Ligustici Chuanxiong extract and Dunaliella extract.
Preferably, the plant extract comprises: 1-2 parts of cortex dictamni extract, 1.5-3 parts of cacumen biotae extract, 0.5-1.5 parts of salvia miltiorrhiza extract, 2-3 parts of cortex cinchona japonica extract, 0.5-0.8 part of coptis extract, 0.8-1.5 parts of ligusticum wallichii extract and 1-2 parts of dunaliella salina extract.
Further preferably, the plant extract comprises: 1.5 parts of cortex dictamni extract, 2 parts of cacumen biotae extract, 1 part of salvia miltiorrhiza extract, 2.5 parts of cortex cinchoniae extract, 0.6 part of coptis extract, 1 part of ligusticum wallichii extract and 1.5 parts of dunaliella salina extract.
Further, the surfactant comprises one or more of sodium laureth sulfate, sodium trideceth sulfate, and di (PPG-2 myristyl polyether-10) adipate.
Preferably, the surfactant comprises 12-14 parts sodium laureth sulfate, 1.5-2 parts sodium trideceth sulfate, and 0.5-0.8 part bis (PPG-2 myristyl polyether-10) adipate.
Further, the preservative comprises one or more of phenoxyethanol, benzyl alcohol, benzoic acid, and sorbic acid.
Preferably, the weight ratio of cocamide MEA, tocopherol, and plant extract is 1-2:0.05-0.1: 15-18.
The invention also provides a preparation method of the plant-derived skin health care whole-body lotion, which comprises the following steps:
(1) heating the agent A;
(2) adding the agent B into the agent A and stirring;
(3) adding the agent C into the mixture obtained in the step (1), and stirring at constant temperature;
(4) and (4) cooling the mixture obtained in the step (3), keeping the temperature constant, adding the agent D, and stirring.
Further, the heating in the step (1) is specifically heating to 80-90 ℃; the stirring time in the step (2) is 10-20 min; the stirring time in the step (3) is 28-32 min; and (4) specifically cooling to below 45 ℃, wherein the stirring time is 25-35 min.
The related extracts in the invention are prepared by the following methods:
the preparation method of the sophora flavescens extract comprises the following steps: taking 30 g of sophora flavescens ait root, crushing, adding 270 g of water, carrying out ultrasonic extraction for 20 minutes with the power of 70 watts, then filtering to obtain filtrate, and concentrating the filtrate to 0.1g/mL to obtain a sophora flavescens ait extract;
the preparation method of the dictamnus dasycarpus root-bark extract comprises the following steps: taking 50 g of cortex dictamni, crushing, adding 400 g of water, performing microwave extraction for 30 minutes at the power of 150 watts, then filtering to obtain filtrate, and concentrating the filtrate to 0.1g/mL to obtain the cortex dictamni extract;
the preparation method of the cacumen biotae extract comprises the following steps: taking 40 g of cacumen biotae, crushing, adding 320 g of water, performing microwave extraction for 30 minutes at the power of 150 watts, then filtering to obtain filtrate, and concentrating the filtrate to 0.1g/mL to obtain an cacumen biotae extract;
the preparation method of the salvia miltiorrhiza extract comprises the following steps: taking 50 g of salvia miltiorrhiza, crushing, adding 400 g of water, carrying out ultrasonic extraction for 40 minutes at the power of 70 watts, then filtering to obtain filtrate, and concentrating the filtrate to 0.1g/mL to obtain a salvia miltiorrhiza extract;
the preparation method of the cortex cinchona extract comprises the following steps: taking 80 g of cortex Cinchonae, crushing, adding 720 g of water, performing microwave extraction for 50 minutes with the power of 150 watts, then filtering to obtain filtrate, and concentrating the filtrate to 0.1g/mL to obtain the extract of the cortex Cinchonae;
the preparation method of the coptis extract comprises the following steps: taking 30 g of coptis chinensis, crushing, adding 240 g of water, carrying out ultrasonic extraction for 20 minutes at the power of 70 watts, then filtering to obtain filtrate, and concentrating the filtrate to 0.1g/mL to obtain a coptis chinensis extract;
the preparation method of the ligusticum wallichii extract comprises the following steps: pulverizing 30 g of ligusticum wallichii, adding 270 g of water, carrying out ultrasonic extraction for 20 minutes with the power of 70 watts, then filtering to obtain filtrate, and concentrating the filtrate to 0.1g/mL to obtain the ligusticum wallichii extract.
The preparation method of the dunaliella salina extract comprises the following steps: taking 30 g of dunaliella salina, crushing, adding 350 g of water, performing microwave extraction for 30 minutes at the power of 150 watts, then filtering to obtain filtrate, and concentrating the filtrate to 0.1g/mL to obtain the dunaliella salina extract.
The technical effects obtained by the invention are as follows:
according to the invention, through the mutual compounding of the raw materials and the addition of the active components, the addition amount of components such as a preservative is effectively reduced, the irritation of related components to the skin is reduced, the safety and the protective performance of the lotion to the skin of the whole body are enhanced while the long quality guarantee time and the product efficacy are ensured.
Detailed Description
It is worth to be noted that the various extracts used in the present invention are prepared by themselves, the preparation method is detailed in the foregoing, and the other raw materials are all common commercial products, so the sources thereof are not specifically limited.
Example 1
A plant-derived skin-care whole-body lotion comprises the following raw materials: an agent A, an agent B, an agent C and an agent D in a weight ratio of 70:16:1.2: 1.5;
wherein, the agent A comprises 14 parts of surfactant and 50 parts of water; the surfactant herein includes 12 parts of sodium laureth sulfate, 1.5 parts of sodium trideceth sulfate and 0.5 part of di (PPG-2 myristyleth-10) adipate;
the agent B comprises: 1 part cocamide MEA, 0.05 part tocopherol and 15 parts plant extract; plant extracts herein include: 1 part of cortex dictamni extract, 1.5 parts of cacumen biotae extract, 0.5 part of salvia miltiorrhiza extract, 2 parts of cortex cinchoniae extract, 0.5 part of coptis extract, 0.8 part of ligusticum wallichii extract and 1 part of dunaliella salina extract;
the agent C comprises 0.3 part of guar hydroxypropyl trimethyl ammonium chloride, 0.2 part of polyquaternium-10 and 0.1 part of hydroxypropyl methyl cellulose;
the agent D comprises: 0.1 part of citric acid, 0.1 part of menthol, 0.1 part of hexamidine di (isethionic acid) salt, 0.2 part of monoglyceride succinate, 0.5 part of potassium lactate, 1 part of L-rhamnose, 0.1 part of sodium chloride and 0.05 part of an antiseptic.
The preparation method of the skin-care whole-body lotion derived from the above substances comprises the following steps:
(1) heating the agent A to 80 ℃;
(2) adding the agent B into the agent A and stirring for 10 min;
(3) adding the agent C into the mixture obtained in the step (1), and stirring for 28min at constant temperature;
(4) and (4) cooling the mixture obtained in the step (3) to below 45 ℃, keeping the temperature, adding the agent D, and stirring for 25 min.
Example 2
A plant-derived skin-care whole-body lotion comprises the following raw materials: agent A, agent B, agent C and agent D in a weight ratio of 75:18:1.5: 2.5;
wherein, the agent A comprises 16.8 parts of surfactant and 60 parts of water; the surfactant herein includes 14 parts of sodium laureth sulfate, 2 parts of sodium trideceth sulfate and 0.8 part of di (PPG-2 myristyleth-10) adipate;
the agent B comprises: 2 parts cocamide MEA, 0.1 part tocopherol and 18 parts plant extract; plant extracts herein include: 2 parts of cortex dictamni extract, 3 parts of cacumen biotae extract, 1.5 parts of salvia miltiorrhiza extract, 3 parts of cortex cinchoniae extract, 0.8 part of coptis extract, 1.5 parts of ligusticum wallichii extract and 2 parts of dunaliella salina extract;
the agent C comprises 0.6 part of guar hydroxypropyl trimethyl ammonium chloride, 0.25 part of polyquaternium-10 and 0.2 part of hydroxypropyl methyl cellulose;
the agent D comprises: 0.2 part of citric acid, 0.2 part of menthol, 0.2 part of hexamidine di (isethionic acid) salt, 0.5 part of monoglyceride succinate, 1 part of potassium lactate, 1.5 parts of L-rhamnose, 0.2 part of sodium chloride and 0.08 part of an antiseptic.
The preparation method of the skin-care whole-body lotion derived from the above substances comprises the following steps:
(1) heating the agent A to 90 ℃;
(2) adding the agent B into the agent A and stirring for 20 min;
(3) adding the agent C into the mixture obtained in the step (1), and stirring at constant temperature for 32 min;
(4) and (4) cooling the mixture obtained in the step (3) to below 45 ℃, keeping the temperature, adding the agent D, and stirring for 35 min.
Example 3
A plant-derived skin-care whole-body lotion comprises the following raw materials: an agent A, an agent B, an agent C and an agent D in a weight ratio of 72:17:1.2: 2;
wherein, the agent A comprises 15.8 parts of surfactant and 55.6 parts of water; the surfactant herein included 13.4 parts sodium laureth sulfate, 1.8 parts sodium trideceth sulfate and 0.6 parts bis (PPG-2 myristyleth-10) adipate;
the agent B comprises: 1.8 parts cocamide MEA, 0.08 parts tocopherol and 16 parts plant extract; the plant extracts comprise 1.5 parts of cortex Dictamni Radicis extract, 2 parts of folium Platycladi extract, 1 part of Saviae Miltiorrhizae radix extract, 2.5 parts of cortex Cinchonae extract, 0.6 part of Coptidis rhizoma extract, 1 part of rhizoma Ligustici Chuanxiong extract and 1.5 parts of Dunaliella salina extract;
the agent C comprises 0.5 part of guar hydroxypropyl trimethyl ammonium chloride, 0.2 part of polyquaternium-10 and 0.2 part of hydroxypropyl methyl cellulose;
the agent D comprises: 0.15 part of citric acid, 0.15 part of menthol, 0.15 part of hexamidine di (isethionic acid) salt, 0.3 part of monoglyceride succinate, 0.6 part of potassium lactate, 1.2 parts of L-rhamnose, 0.15 part of sodium chloride and 0.06 part of preservative.
The preparation method of the skin-care whole-body lotion derived from the above substances comprises the following steps:
(1) heating the agent A to 85 ℃;
(2) adding the agent B into the agent A and stirring for 15 min;
(3) adding the agent C into the mixture obtained in the step (1), and stirring for 30min at constant temperature;
(4) and (4) cooling the mixture obtained in the step (3) to below 45 ℃, keeping the temperature, adding the agent D, and stirring for 30 min.
Comparative example 1
The only difference from example 1 is that the agent a comprises 13 parts surfactant and 65 parts water;
the agent B comprises: 0.8 parts cocamide MEA, 0.15 parts tocopherol and 14 parts plant extract;
the agent C comprises 0.2 part of guar hydroxypropyl trimethyl ammonium chloride, 0.3 part of polyquaternium-10 and 0.08 part of hydroxypropyl methyl cellulose;
the agent D comprises: 0.08 part of citric acid, 0.25 part of menthol, 0.08 part of hexamidine di (isethionic acid) salt, 0.26 part of monoglyceride succinate, 0.4 part of potassium lactate, 1.2 parts of L-rhamnose, 0.08 part of sodium chloride and 0.1 part of preservative.
The composition of the surfactant and the composition of the plant extract were also the same as in example 1.
Comparative example 2
The only difference from example 1 is that the weight ratio of cocamide MEA, tocopherol and plant extract was 2.5:0.03:20 (the total weight of the three was identical to example 1).
Comparative example 3
The only difference from example 1 is that the dunaliella salina extract was replaced with the same amount of sophora flavescens extract.
Comparative example 4
The washing liquid of example 2 in patent CN 202010414376.2.
The invention relates to a test method for irritation test of washing liquor, which comprises the following steps: reference is made to technical guide principles [ S ].2005-3 ] of local irritation and hemolysis research of traditional Chinese medicines and natural medicines by GPT4-1 and technical guide principles [ S ].2014-5-13 ] of irritation, allergy and hemolysis research by national food and drug administration.
In particular, 28 healthy adult rabbits are prepared, each male and female rabbit is divided into 7 groups at random, each group comprises 4 rabbits, two areas, namely a complete skin area and a damaged skin area (after cleaning and disinfection, a sterile needle is used for slightly scratching the hairless area until the skin is subjected to blood seepage, the area is 24 hours before the test), the left side skin area is uniformly coated with the lotion in each example of the invention according to the group, the right side skin area is coated with deionized water as a control group, the corresponding area is covered with gauze after coating, the skin is cleaned after 5 hours, the skin is continuously coated for one week, the erythema and edema conditions of the corresponding positions are observed and recorded before and after coating, the erythema formation conditions of edema is observed after 1 hour, 24 hours, 48 hours and 72 hours after last administration, the scoring is carried out according to table 1, and the average reaction value is calculated, namely, the following equation is satisfied:
average reaction value (total edema formation score + total erythema formation score)/total number of animals
The corresponding scoring criteria for skin irritation intensity are shown in table 2, and after the scores are calculated, the test results are counted in table 3.
TABLE 1 skin irritation response Scoring criteria
TABLE 2 skin irritation Strength scoring criteria
| Scoring (score) | Evaluation of |
| 0-0.49 | Has no irritation |
| 0.5-2.99 | Mild irritation |
| 3.0-5.99 | Moderate irritation |
| 6.0-8.0 | Severe irritation |
TABLE 3 results of the irritation test of the lotion of the present invention
| Examples of the invention | Scoring (score) | Evaluation of |
| Example 1 | 0 | Has no irritation |
| Example 2 | 0 | Has no irritation |
| Example 3 | 0.25 | Has no irritation |
| Comparative example 1 | 3.25 | Moderate irritation |
| Comparative example 2 | 1.00 | Mild irritation |
| Comparative example 3 | 0.5 | Mild irritation |
| Comparative example 4 | 1.75 | Mild irritation |
As can be seen from Table 3, the lotion of the present invention and the lotion of comparative example 3 were non-irritating, indicating that the lotions of the present invention and comparative example 3 were milder, non-irritating to the skin and more safe. In comparison, the remaining comparative lotions had a certain irritant effect, especially with regard to the skin in the damaged area, which was very prone to redness or erythema.
The invention relates to a test method for the bacteriostatic effect of lotion, which comprises the following steps: the tests are carried out according to the technical requirements of GB 19877.1-2005 'Special hand sanitizer', and the tests stipulate that a bacteriostasis test is carried out by using a test method of QB/T2738-2012 'evaluation method for antibacterial and bacteriostatic effects of daily chemical products'. The specific strains use escherichia coli (ATCC 25922) and staphylococcus aureus (ATCC 6538) and lotion in each example with the action concentration of 1:1, the action time is 2min, and after three parallel tests, the results of evaluation on the average bacteriostatic rate and bacteriostatic effect (B1 grade: bacteriostatic rate is more than or equal to 90%, B2 grade: bacteriostatic rate is more than or equal to 50% and less than 90%, B3 grade: bacteriostatic rate is less than 50%) are counted in a table 4.
TABLE 4 bacteriostatic effect test results of the lotion of the present invention
As can be seen from Table 4, the lotion of each example of the present invention has B1 grade antibacterial effect on Staphylococcus aureus and Escherichia coli, and has excellent antibacterial ability. In contrast, the comparative example had a relatively poor bacteriostatic effect with respect to the lotion.
Finally, it should be noted that the above-mentioned contents are only used for illustrating the technical solutions of the present invention, and not for limiting the protection scope of the present invention, and that the simple modifications or equivalent substitutions of the technical solutions of the present invention by those of ordinary skill in the art can be made without departing from the spirit and scope of the technical solutions of the present invention.
Claims (10)
1. A plant-derived skin-care whole-body lotion is characterized in that: the raw materials comprise: agent A, agent B, agent C and agent D;
the agent A comprises a surfactant and water;
the agent B comprises: cocamide MEA, tocopherol, and plant extracts;
the agent C comprises one or more of guar hydroxypropyl trimethyl ammonium chloride, polyquaternium-10 and hydroxypropyl methyl cellulose;
the agent D comprises: citric acid, menthol, hexamidine di (isethionate) salt, succinic acid monoglyceride, potassium lactate, L-rhamnose, sodium chloride, and an antiseptic.
2. The plant-derived skin health-care systemic lotion according to claim 1, characterized in that: the weight ratio of the agent A to the agent B to the agent C to the agent D is 70-75:16-18:1.2-1.5: 1.5-2.5.
3. The plant-derived skin health-care systemic lotion according to claim 1, characterized in that: the weight ratio of the agent B to the agent D is 16-18: 2-3.
4. The plant-derived skin health-care systemic lotion according to claim 1, characterized in that:
the agent A comprises 4-16.8 parts of surfactant and 50-60 parts of water;
the agent B comprises: 1-2 parts of cocamide MEA, 0.05-0.1 part of tocopherol and 15-18 parts of plant extract;
the agent C comprises 0.3-0.6 part of guar hydroxypropyl trimethyl ammonium chloride, 0.2-0.25 part of polyquaternium-10 and 0.1-0.2 part of hydroxypropyl methyl cellulose;
the agent D comprises: 0.1-0.2 part of citric acid, 0.1-0.2 part of menthol, 0.1-0.2 part of hexamidine di (isethionic acid) salt, 0.2-0.5 part of monoglyceride succinate, 0.5-1 part of potassium lactate, 1-1.5 parts of L-rhamnose, 0.1-0.2 part of sodium chloride and 0.05-0.08 part of preservative.
5. The plant-derived skin health-care systemic lotion according to claim 1, characterized in that: the plant extract comprises: one or more of radix Sophorae Flavescentis extract, cortex Dictamni Radicis extract, folium Platycladi extract, Saviae Miltiorrhizae radix extract, cortex Cinchonae extract, Coptidis rhizoma extract, rhizoma Ligustici Chuanxiong extract and Dunaliella extract.
6. The plant-derived skin health-care systemic lotion according to claim 1, characterized in that: the plant extract comprises: 1-2 parts of cortex dictamni extract, 1.5-3 parts of cacumen biotae extract, 0.5-1.5 parts of salvia miltiorrhiza extract, 2-3 parts of cortex cinchona japonica extract, 0.5-0.8 part of coptis extract, 0.8-1.5 parts of ligusticum wallichii extract and 1-2 parts of dunaliella salina extract.
7. The plant-derived skin health-care systemic lotion according to claim 1, characterized in that: the surfactant comprises one or more of sodium laureth sulfate, sodium trideceth sulfate, and di (PPG-2 myristyl polyether-10) adipate.
8. The plant-derived skin health-care systemic lotion according to claim 1, characterized in that: the antiseptic comprises one or more of phenoxyethanol, benzyl alcohol, benzoic acid and sorbic acid.
9. The plant-derived skin health-care systemic lotion according to claim 1, characterized in that: the weight ratio of the cocamide MEA to the tocopherol to the plant extract is 1-2:0.05-0.1: 15-18.
10. The method of preparing a plant-derived skin-care systemic lotion according to claim 1, wherein: the method comprises the following steps:
(1) heating the agent A;
(2) adding the agent B into the agent A and stirring;
(3) adding the agent C into the mixture obtained in the step (1), and stirring at constant temperature;
(4) and (4) cooling the mixture obtained in the step (3), keeping the temperature constant, adding the agent D, and stirring.
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| CN111407707A (en) * | 2020-05-15 | 2020-07-14 | 广州路标科技有限公司 | Plant-derived skin health-care lotion and preparation method thereof |
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| CN111407707A (en) * | 2020-05-15 | 2020-07-14 | 广州路标科技有限公司 | Plant-derived skin health-care lotion and preparation method thereof |
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