CN108078903B - A kind of plant acne-removing composition and preparation method thereof - Google Patents
A kind of plant acne-removing composition and preparation method thereof Download PDFInfo
- Publication number
- CN108078903B CN108078903B CN201810105071.6A CN201810105071A CN108078903B CN 108078903 B CN108078903 B CN 108078903B CN 201810105071 A CN201810105071 A CN 201810105071A CN 108078903 B CN108078903 B CN 108078903B
- Authority
- CN
- China
- Prior art keywords
- extract
- parts
- propolis
- mangosteen
- honeysuckle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 206010000496 acne Diseases 0.000 title claims abstract description 71
- 208000002874 Acne Vulgaris Diseases 0.000 title claims abstract description 66
- 239000000203 mixture Substances 0.000 title claims abstract description 59
- 238000002360 preparation method Methods 0.000 title claims abstract description 20
- 241000241413 Propolis Species 0.000 claims abstract description 70
- 229940069949 propolis Drugs 0.000 claims abstract description 70
- 241000196324 Embryophyta Species 0.000 claims abstract description 55
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 40
- 241000205585 Aquilegia canadensis Species 0.000 claims abstract description 38
- 240000006053 Garcinia mangostana Species 0.000 claims abstract description 38
- 235000017048 Garcinia mangostana Nutrition 0.000 claims abstract description 38
- 244000197580 Poria cocos Species 0.000 claims abstract description 38
- 235000008599 Poria cocos Nutrition 0.000 claims abstract description 38
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 claims abstract description 37
- 229940067866 dandelion extract Drugs 0.000 claims abstract description 29
- 235000020691 dandelion extract Nutrition 0.000 claims abstract description 29
- 239000001845 taraxacum officinale leaf extract Substances 0.000 claims abstract description 29
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 claims abstract description 21
- 229940083466 soybean lecithin Drugs 0.000 claims abstract description 21
- 244000236658 Paeonia lactiflora Species 0.000 claims abstract description 14
- 235000008598 Paeonia lactiflora Nutrition 0.000 claims abstract description 14
- 239000002994 raw material Substances 0.000 claims abstract description 10
- 241000132012 Atractylodes Species 0.000 claims abstract description 9
- 241000304195 Salvia miltiorrhiza Species 0.000 claims abstract 10
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 36
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 18
- 235000006484 Paeonia officinalis Nutrition 0.000 claims description 18
- 241001106477 Paeoniaceae Species 0.000 claims description 18
- 239000000843 powder Substances 0.000 claims description 17
- 238000003756 stirring Methods 0.000 claims description 15
- 238000002156 mixing Methods 0.000 claims description 14
- 229920000223 polyglycerol Polymers 0.000 claims description 14
- 238000002390 rotary evaporation Methods 0.000 claims description 10
- 241000245665 Taraxacum Species 0.000 claims description 9
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 claims description 9
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims description 9
- 235000001188 Peltandra virginica Nutrition 0.000 claims description 8
- 238000001291 vacuum drying Methods 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 6
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 5
- 239000002202 Polyethylene glycol Substances 0.000 claims description 5
- 238000000605 extraction Methods 0.000 claims description 5
- 239000004744 fabric Substances 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 5
- 229940067606 lecithin Drugs 0.000 claims description 5
- 235000010445 lecithin Nutrition 0.000 claims description 5
- 239000000787 lecithin Substances 0.000 claims description 5
- 229920001223 polyethylene glycol Polymers 0.000 claims description 5
- 238000002791 soaking Methods 0.000 claims description 5
- 238000005303 weighing Methods 0.000 claims description 5
- 230000001376 precipitating effect Effects 0.000 claims description 3
- 235000013399 edible fruits Nutrition 0.000 claims description 2
- 241000132011 Atractylodes lancea Species 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 15
- 239000000126 substance Substances 0.000 abstract description 8
- 230000007794 irritation Effects 0.000 abstract description 5
- 231100000331 toxic Toxicity 0.000 abstract description 4
- 230000002588 toxic effect Effects 0.000 abstract description 4
- 239000000022 bacteriostatic agent Substances 0.000 abstract description 3
- 244000132619 red sage Species 0.000 description 27
- 210000003491 skin Anatomy 0.000 description 14
- 238000000034 method Methods 0.000 description 11
- 238000012360 testing method Methods 0.000 description 8
- 239000003814 drug Substances 0.000 description 6
- 208000017520 skin disease Diseases 0.000 description 6
- 206010061218 Inflammation Diseases 0.000 description 5
- 230000004054 inflammatory process Effects 0.000 description 5
- 238000011282 treatment Methods 0.000 description 5
- 208000020154 Acnes Diseases 0.000 description 4
- 206010040880 Skin irritation Diseases 0.000 description 4
- 239000002537 cosmetic Substances 0.000 description 4
- 230000002401 inhibitory effect Effects 0.000 description 4
- 238000001556 precipitation Methods 0.000 description 4
- 230000036556 skin irritation Effects 0.000 description 4
- 231100000475 skin irritation Toxicity 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 206010011732 Cyst Diseases 0.000 description 3
- 241000628997 Flos Species 0.000 description 3
- 241000233866 Fungi Species 0.000 description 3
- 241001619461 Poria <basidiomycete fungus> Species 0.000 description 3
- 206010037888 Rash pustular Diseases 0.000 description 3
- 241000700605 Viruses Species 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 230000007012 clinical effect Effects 0.000 description 3
- 208000031513 cyst Diseases 0.000 description 3
- 230000007547 defect Effects 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 208000029561 pustule Diseases 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 239000000341 volatile oil Substances 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- 229910052785 arsenic Inorganic materials 0.000 description 2
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 2
- 229960003957 dexamethasone Drugs 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 241000411851 herbal medicine Species 0.000 description 2
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 2
- 229910052753 mercury Inorganic materials 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 210000002374 sebum Anatomy 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000013112 stability test Methods 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 231100000820 toxicity test Toxicity 0.000 description 2
- 238000009602 toxicology test Methods 0.000 description 2
- 239000003053 toxin Substances 0.000 description 2
- 231100000765 toxin Toxicity 0.000 description 2
- 108700012359 toxins Proteins 0.000 description 2
- 229940126680 traditional chinese medicines Drugs 0.000 description 2
- 241000213006 Angelica dahurica Species 0.000 description 1
- 241000092665 Atractylodes macrocephala Species 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 241001313857 Bletilla striata Species 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 244000077995 Coix lacryma jobi Species 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 244000166675 Cymbopogon nardus Species 0.000 description 1
- 235000018791 Cymbopogon nardus Nutrition 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- 206010016936 Folliculitis Diseases 0.000 description 1
- 206010017533 Fungal infection Diseases 0.000 description 1
- 208000007514 Herpes zoster Diseases 0.000 description 1
- 206010021531 Impetigo Diseases 0.000 description 1
- 241001071917 Lithospermum Species 0.000 description 1
- 241000218378 Magnolia Species 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- 201000009053 Neurodermatitis Diseases 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 244000299790 Rheum rhabarbarum Species 0.000 description 1
- 235000009411 Rheum rhabarbarum Nutrition 0.000 description 1
- 241000220317 Rosa Species 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 240000007164 Salvia officinalis Species 0.000 description 1
- 240000004534 Scutellaria baicalensis Species 0.000 description 1
- 235000017089 Scutellaria baicalensis Nutrition 0.000 description 1
- 240000009022 Smilax rotundifolia Species 0.000 description 1
- 235000003205 Smilax rotundifolia Nutrition 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 244000098338 Triticum aestivum Species 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 208000038016 acute inflammation Diseases 0.000 description 1
- 230000006022 acute inflammation Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000001363 autoimmune Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 239000013043 chemical agent Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 208000037976 chronic inflammation Diseases 0.000 description 1
- 230000006020 chronic inflammation Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 229960002227 clindamycin Drugs 0.000 description 1
- KDLRVYVGXIQJDK-AWPVFWJPSA-N clindamycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 KDLRVYVGXIQJDK-AWPVFWJPSA-N 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000001066 destructive effect Effects 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 206010013663 drug dependence Diseases 0.000 description 1
- 238000005485 electric heating Methods 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000003631 expected effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000005562 fading Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 229910052602 gypsum Inorganic materials 0.000 description 1
- 239000010440 gypsum Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 208000002557 hidradenitis Diseases 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 238000002647 laser therapy Methods 0.000 description 1
- 238000013532 laser treatment Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000004630 mental health Effects 0.000 description 1
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 1
- 229960000282 metronidazole Drugs 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 230000004792 oxidative damage Effects 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 235000005412 red sage Nutrition 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 230000036573 scar formation Effects 0.000 description 1
- 210000001732 sebaceous gland Anatomy 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 208000011117 substance-related disease Diseases 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 229940126673 western medicines Drugs 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Birds (AREA)
- Zoology (AREA)
- Dermatology (AREA)
- Insects & Arthropods (AREA)
- Animal Husbandry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
本发明公开了一种植物祛痘组合物及其制备方法，100重量份的组合物由以下原料组成，蜂胶提取物6～25份；白芍提取物0.5～4.0份；金银花提取物1.0～5.0份；山竹果提取物1.0～4.0份；丹参提取物0.5～2.5份；蒲公英提取物0.3～3.5份；苍术提取物0.5～3.0份；茯苓提取物1.0～4.0份；大豆卵磷脂3.0～10.0份，余量为水，其制备方法简单、易操作。该植物祛痘组合物不含化学抑菌剂，无刺激、无毒副作用、性能稳定，是一种安全可靠的纯天然蜂胶皮肤护理外用剂。
The invention discloses a plant acne-removing composition and a preparation method thereof. 100 parts by weight of the composition is composed of the following raw materials: 6-25 parts of propolis extract; 0.5-4.0 parts of white peony root extract; 1.0-5.0 parts of honeysuckle extract 1.0-4.0 parts of mangosteen extract; 0.5-2.5 parts of Salvia miltiorrhiza extract; 0.3-3.5 parts of dandelion extract; 0.5-3.0 parts of Atractylodes extract; 1.0-4.0 parts of Poria cocos extract; 3.0-10.0 parts of soybean lecithin , the remainder is water, and the preparation method is simple and easy to operate. The plant acne-removing composition does not contain chemical bacteriostatic agents, has no irritation, has no toxic side effects, and has stable performance, and is a safe and reliable pure natural propolis skin care external preparation.
Description
Technical Field
The invention belongs to the technical field of human skin care, and particularly relates to a plant acne-removing composition and a preparation method thereof.
Background
Acne, comedo, whelk and the like are common and common skin diseases, particularly whelk, and teenagers are generally troubled by the acne, the whelk and the teenagers to different degrees. The skin diseases such as acne, comedo and whelk are caused by a lot of inducements, mainly due to inflammation and obstruction of skin sacs and sebaceous glands of the skin epidermis, and particularly from the perspective of western medicine, the skin diseases can be divided into three categories of fungal infection, bacterial infection and viral infection, the disease course is long, the skin diseases are easy to relapse, and the physical and mental health of patients is influenced. The existing acne removing methods and the types of medicines are also many, such as: laser therapy, western medicines such as salicylic acid, clindamycin, metronidazole, dexamethasone and plant essential oil such as rose essential oil. In the above treatment method, laser treatment cannot eradicate acne and has a destructive effect on skin tissues; the single western medicine treatment easily causes drug dependence on patients and has large side effect; the plant essential oil has good treatment effect, but has long treatment time and high price and cannot be accepted by the public. In addition, there is also a traditional Chinese medicine therapy, for example, the invention patent 201110421645.9 discloses an acne removing cream for external application, which comprises the following components in parts by weight: pearl powder: gypsum powder: plum slice: lithospermum: rhubarb: wheat germ: glabrous greenbrier rhizome: ploughshare grass: citronella: coix seed is 30:15:10:10:5:15:15:15:15: 20; the invention patent 200810053192.7 discloses an acne removing cream, which comprises the following medicines, by weight, 0.9-3.8 parts of bletilla striata, 1-4.5 parts of angelica dahurica I, 0.7-4.1 parts of scutellaria baicalensis and 1-2.4 parts of magnolia flower; the traditional Chinese medicines have good effects on treating skin diseases such as acne, pimple and comedo from the perspective of 'monarch, minister and guide', but the traditional Chinese medicines need dialectical use, are only suitable for a small part of patients, and have long treatment period.
Clinical tests show that the propolis is effective on skin itch, neurodermatitis, folliculitis, hidradenitis, youth acne and the like; it is also effective on infectious dermatoses such as impetigo and herpes zoster. The propolis has strong antibacterial and anti-inflammatory effects, can relieve pain locally, improve subcutaneous tissue blood circulation, limit scar formation, nourish skin, and protect skin from damage of chemical substances such as acid and alkali. However, most of propolis is a water-insoluble component, and ethanol is often used as a solvent in the preparation of a liquid preparation, and the ethanol preparation is highly irritating to the skin and is difficult to be effectively popularized.
Disclosure of Invention
The invention aims to overcome the defects in the prior art and provide a plant acne-removing composition, which is prepared by selecting pure natural Chinese herbal medicines such as white paeony root, honeysuckle flower, mangosteen, salvia miltiorrhiza, dandelion, atractylodes macrocephala koidz, poria cocos and the like, scientifically matching and extracting and refining, effectively retaining active ingredients of the plants, effectively killing harmful bacteria, fungi and viruses, effectively removing severe cyst-type, pustule-type and papular-type acnes, and having synergistic effects and effects on regulating sebum secretion and skin acid-base balance and removing toxins and the like while removing acnes.
The technical scheme of the invention is as follows:
a plant acne-removing composition comprises, by weight, 100 parts of a composition, 6-25 parts of a propolis extract; 0.5-4.0 parts of white peony root extract; 1.0-5.0 parts of honeysuckle extract; 1.0-4.0 parts of mangosteen extract; 0.5-2.5 parts of salvia miltiorrhiza extract; 0.3-3.5 parts of dandelion extract; 0.5-3.0 parts of rhizoma atractylodis extract; 1.0-4.0 parts of poria cocos extract; 3.0-10.0 parts of soybean lecithin and the balance of water.
The preparation method comprises the following steps:
(1) preparation of propolis extract:
(a) the ratio of propolis to ethyl acetate in ml is 1: 2-8, soaking propolis at room temperature for 2-3 days, and then removing ethyl acetate from the separated extract through rotary evaporation to obtain a propolis extract E1, wherein the rotary evaporation is carried out at the temperature of 50-65 ℃;
(b) according to the ratio of the propolis extract E1 in grams to the polyethylene glycol in grams of 1: 4-8, and fully dissolving the mixture in a water bath kettle at the temperature of 75-85 ℃ to obtain an extracting solution E2;
(c) the weight ratio of the extracting solution E2 to the polyglycerol monostearate is 1: 2-4, adding polyglycerol monostearate into the extracting solution E2, and fully stirring and dissolving to obtain the propolis extract F;
(2) preparing a white paeony root extract, a honeysuckle extract, a mangosteen extract, a salvia miltiorrhiza extract, a dandelion extract, a atractylodes rhizome extract and a poria cocos extract:
respectively crushing radix paeoniae alba, honeysuckle, mangosteen, salvia miltiorrhiza, dandelion, rhizoma atractylodis and poria cocos into powder, adding the powder into a multifunctional extraction tank, and mixing the powder with water according to the weight ratio of 1: 4-10, decocting in water for 2-4 times, each time for 15-60 minutes, combining decoctions, concentrating, adding ethanol while stirring, precipitating overnight, filtering through 300-400 meshes of filter cloth, and vacuum drying to obtain a white paeony root extract, a honeysuckle flower extract, a mangosteen fruit extract, a salvia miltiorrhiza extract, a dandelion extract, a rhizoma atractylodis extract and a poria cocos extract respectively, wherein the vacuum drying is carried out at the temperature of 40-60 ℃ and the vacuum degree of-0.07-0.1 MPa;
(3) weighing the balance of water, dissolving soybean lecithin in water to prepare a lecithin solution, adding the white paeony root extract, the honeysuckle extract, the mangosteen extract, the salvia miltiorrhiza extract, the dandelion extract, the rhizoma atractylodis extract and the poria cocos extract in parts by weight respectively, and fully dissolving the materials by using a stirring homogenizer; finally adding propolis extract F to obtain the plant acne-removing composition.
Wherein the granularity of the white paeony root, the honeysuckle, the mangosteen, the salvia miltiorrhiza, the dandelion, the rhizoma atractylodis and the tuckahoe is 100-200 meshes.
The propolis extract is extracted by a step-by-step method, and the main purpose is to extract active substances in the propolis to the maximum extent, so that the propolis is further emulsified to form a water-soluble system; the main function of the addition of polyglycerol monostearate is to enable the components of the propolis to dissolve in water. The weight ratio of the extracting solution E2 to the polyglycerol monostearate is 1: 2-4, if the weight ratio of the extracting solution E2 to the polyglycerol monostearate is more than 1: 2, the ingredients in the prepared propolis can not be completely dissolved in water; if the weight ratio of the extracting solution E2 to the polyglycerol monostearate is less than 1: 4, the content of propolis is too low.
In the invention, the white paeony root extract has the main functions of inhibiting autoimmune reaction, resisting inflammation and relieving pain; the honeysuckle extract has the main functions of diminishing inflammation and resisting bacteria; the mangosteen extract has the main functions of inhibiting oxidative damage, resisting inflammation and relieving pain; the red sage root extract has the main functions of improving microcirculation, inhibiting the generation of collagen fibers, promoting the degradation of fibrin, resisting inflammation and the like; the dandelion extract has the main functions of clearing away heat and toxic materials, relieving swelling and dissipating stagnation; the rhizoma Atractylodis extract has main effects in resisting cocci, bacilli, fungi and viruses; the tuckahoe extract has the main function of inhibiting acute and chronic inflammation; the main function of soybean lecithin is to emulsify water-insoluble substances.
In the invention, 100 parts by weight of the plant acne-removing composition, the parts by weight of each seed of the white peony root extract, the honeysuckle extract, the mangosteen extract, the salvia miltiorrhiza extract, the dandelion extract, the atractylodes rhizome extract and the poria cocos extract are within the range, and if the propolis extract is less than 6 parts by weight, the finished product has low bacteriostatic activity and poor curative effect; if the propolis extract is more than 25 parts by weight, the product stability is poor; therefore, the propolis extract is 6 to 25 parts by weight;
when the weight parts of the white paeony root extract, the honeysuckle extract, the mangosteen extract, the salvia miltiorrhiza extract, the dandelion extract, the rhizoma atractylodis extract and the poria cocos extract are less than the respective weight parts, the expected effect cannot be achieved; if their parts by weight are more than the respective ranges of parts by weight described above, the stability of the product is affected; therefore, the weight parts of the white peony root extract, the honeysuckle extract, the mangosteen extract, the salvia miltiorrhiza extract, the dandelion extract, the atractylodes rhizome extract and the poria cocos extract are respectively 0.5-4.0 parts, 1.0-5.0 parts, 1.0-4.0 parts, 0.5-2.5 parts, 0.3-3.5 parts, 0.5-3.0 parts and 1.0-4.0 parts.
The weight part of the soybean lecithin is within the above range, and if the weight part of the soybean lecithin is less than the above range, the intended effect is not obtained; if their weight parts are more than the above range, the solution is viscous and gives poor skin feel; therefore, the weight part of the soybean lecithin is 3.0-10.0 parts.
Preferably, the plant acne-removing composition comprises the following raw materials in 100 parts by weight: 10-20 parts of propolis extract; 1.2-3.0 parts of white peony root extract; 1.5-4.0 parts of honeysuckle extract; 1.5-3.0 parts of mangosteen extract; 0.8-2.2 parts of a salvia miltiorrhiza extract; 0.6-2.5 parts of dandelion extract; 1.0-2.5 parts of rhizoma atractylodis extract; 1.5-3.0 of tuckahoe extract; 4.0-8.0 parts of soybean lecithin; the balance being water.
Preferably, the plant acne-removing composition comprises the following raw materials in 100 parts by weight: 15.0 parts of propolis extract; 1.5 parts of white peony root extract; 2.8 parts of honeysuckle extract; 2.2 parts of mangosteen extract; 1.5 parts of salvia miltiorrhiza extract; 1.7 parts of dandelion extract; 1.4 parts of rhizoma atractylodis extract; 2.3 parts of tuckahoe extract; 6.0 parts of soybean lecithin; the balance being water.
The plant acne-removing composition can be smeared as a skin-care external agent.
The propolis used in the present invention is a product currently marketed, for example, by Hangzhou Tianchu bee health products Co., Ltd. The ethyl acetate used in the present invention is a food grade or pharmaceutical grade product currently marketed, for example, by kaifeng, baichuan huibao limited under the trade name ethyl acetate.
The invention has the beneficial effects that:
the invention overcomes the defects that the conventional propolis needs to adopt ethanol as a solvent, or the embarrassment that bacteriostatic agents, chemical agents or ethanol are required to be added into a water solution, and the technical defects of poor stability, high viscosity, strong irritation, easy precipitation and the like of a finished product, and provides the pure natural propolis skin care external preparation which does not contain chemical bacteriostatic agents, has no irritation, no toxic or side effect, stable performance, safety and reliability.
Compared with the existing acne removing product, the plant acne removing composition has the following characteristics:
1. it contains no chemical bacteriostat, has no irritation, no toxic side effect and stable product performance.
2. Propolis is adopted as a main active ingredient, pure natural Chinese herbal medicines such as white paeony root, honeysuckle, mangosteen, salvia miltiorrhiza, dandelion, atractylodes, poria cocos and the like are selected, scientifically matched and extracted to prepare the propolis skin care external preparation, the active ingredients of plants in the propolis are effectively retained, the propolis skin care external preparation is mutually and stably matched, the inhibition effect of the propolis on harmful bacteria, fungi and viruses can be fully exerted, severe cyst-type, pustule-type and papular-type whelks can be effectively removed, and the propolis skin care external preparation has synergistic effects and effects on regulating sebum secretion and skin acid-base balance and removing toxins and the like while removing acnes, and is safe and reliable.
3. The plant acne-removing composition has the advantages of wide raw material obtaining range, simple and easy preparation method, economy and strong practicability.
Drawings
Fig. 1 shows the result of the microbial detection of the plant acne-removing composition prepared in example 5;
fig. 2 is the result of the phytosanitary chemical index test of the plant acne-removing composition prepared in example 5;
fig. 3 shows the results of multiple skin irritation tests of the plant acne-removing composition prepared in example 5 on rabbits;
fig. 4 shows the clinical effect of the plant acne-removing composition prepared in example 5.
Detailed Description
Example 1
A plant acne-removing composition comprises (by weight parts) propolis extract 6.0; 0.5 part of white peony root extract; 1.0 part of honeysuckle extract; 1.0 part of mangosteen extract; 0.5 part of salvia miltiorrhiza extract; 0.3 part of dandelion extract; 0.5 part of rhizoma atractylodis extract; 1.0 part of tuckahoe extract; 3.0 parts of soybean lecithin and the balance of water.
The method comprises the following specific steps:
(1) preparation of propolis extract:
(a) the ratio of propolis to ethyl acetate in milliliters in grams is 1: 2 mixing, soaking propolis at room temperature for 2 days, and performing rotary evaporation to remove ethyl acetate to obtain propolis extract E1, wherein the rotary evaporation is performed at 50 deg.C;
(b) according to the ratio of the propolis extract E1 in grams to the polyethylene glycol in grams of 1: 4 mixing, and dissolving in 75 deg.C water bath to obtain extractive solution E2;
(c) the weight ratio of the extracting solution E2 to the polyglycerol monostearate is 1: 2, adding polyglycerol monostearate into the extract E2, and fully stirring for dissolving to obtain the propolis extract F.
(2) Preparing a white paeony root extract, a honeysuckle extract, a mangosteen extract, a salvia miltiorrhiza extract, a dandelion extract, a atractylodes rhizome extract and a poria cocos extract:
respectively crushing radix paeoniae alba, honeysuckle, mangosteen, salvia miltiorrhiza, dandelion, rhizoma atractylodis and poria cocos into powder, adding the powder into a multifunctional extraction tank, and mixing the powder with water according to the weight ratio of 1: 4 decocting in water for 2 times, each time for 15 minutes, mixing decoctions, concentrating, adding ethanol while stirring, precipitating overnight, filtering with 300 mesh filter cloth, vacuum drying to obtain radix Paeoniae alba extract, flos Lonicerae extract, fructus Garciniae extract, Saviae Miltiorrhizae radix extract, herba Taraxaci extract, rhizoma Atractylodis extract and Poria extract, respectively, and vacuum drying at 40 deg.C under-0.07 MPa.
(3) Weighing the balance of water, dissolving soybean lecithin in water to prepare a lecithin solution, adding the white paeony root extract, the honeysuckle extract, the mangosteen extract, the salvia miltiorrhiza extract, the dandelion extract, the rhizoma atractylodis extract and the poria cocos extract in parts by weight respectively, and fully dissolving the materials by using a stirring homogenizer; finally adding propolis extract F to obtain the plant acne-removing composition.
Example 2
A plant acne-removing composition, 100 weight parts of which comprises the following raw materials, 25.0 parts of propolis extract; 4.0 parts of white peony root extract; 5.0 parts of honeysuckle extract; 4.0 parts of mangosteen extract; 2.5 parts of salvia miltiorrhiza extract; 3.5 parts of dandelion extract; 3.0 parts of rhizoma atractylodis extract; 4.0 parts of poria cocos extract; 10.0 parts of soybean lecithin and the balance of water.
The method comprises the following specific steps:
(1) preparation of propolis extract:
(a) the ratio of propolis to ethyl acetate in milliliters in grams is 1: 8 mixing, soaking propolis at room temperature for 3 days, and performing rotary evaporation to remove ethyl acetate to obtain propolis extract E1, wherein the rotary evaporation is performed at 65 deg.C;
(b) according to the ratio of the propolis extract E1 in grams to the polyethylene glycol in grams of 1: 8, mixing, and fully dissolving in a water bath kettle at 85 ℃ to obtain an extracting solution E2;
(c) the weight ratio of the extracting solution E2 to the polyglycerol monostearate is 1: 4, adding polyglycerol monostearate into the extracting solution E2, and fully stirring and dissolving to obtain the propolis extract F.
(2) Preparing a white paeony root extract, a honeysuckle extract, a mangosteen extract, a salvia miltiorrhiza extract, a dandelion extract, a atractylodes rhizome extract and a poria cocos extract:
(a) respectively crushing radix paeoniae alba, honeysuckle, mangosteen, salvia miltiorrhiza, dandelion, rhizoma atractylodis and poria cocos into powder, adding the powder into a multifunctional extraction tank, and mixing the powder with water according to the weight ratio of 1: 10 decocting in water for 4 times, each time for 60 minutes, mixing decoctions, concentrating, adding ethanol while stirring, standing overnight for precipitation, filtering with 400 mesh filter cloth, and vacuum drying at 60 deg.C under 0.1MPa to obtain radix Paeoniae alba extract, flos Lonicerae extract, fructus Garciniae extract, Saviae Miltiorrhizae radix extract, herba Taraxaci extract, rhizoma Atractylodis extract and Poria extract.
(3) Weighing the balance of water, dissolving soybean lecithin in water to prepare a lecithin solution, adding the white paeony root extract, the honeysuckle extract, the mangosteen extract, the salvia miltiorrhiza extract, the dandelion extract, the rhizoma atractylodis extract and the poria cocos extract in parts by weight respectively, and fully dissolving the materials by using a stirring homogenizer; finally adding propolis extract F to obtain the plant acne-removing composition.
Example 3
A plant acne-removing composition, 100 weight parts of which comprises the following raw materials, 10.0 parts of propolis extract; 1.2 parts of white peony root extract; 1.5 parts of honeysuckle extract; 1.5 parts of mangosteen extract; 0.8 part of salvia miltiorrhiza extract; 0.6 part of dandelion extract; 1.0 part of rhizoma atractylodis extract; 1.5 parts of tuckahoe extract; 4.0 parts of soybean lecithin and the balance of water.
The method comprises the following specific steps:
(1) preparation of propolis extract:
(a) the ratio of propolis to ethyl acetate in milliliters in grams is 1: 5 mixing, soaking propolis at room temperature for 2 days, and performing rotary evaporation to remove ethyl acetate to obtain propolis extract E1, wherein the rotary evaporation is performed at 58 deg.C;
(b) according to the ratio of the propolis extract E1 in grams to the polyethylene glycol in grams of 1: 6 mixing, and fully dissolving in a water bath kettle at 80 ℃ to obtain an extracting solution E2;
(c) the weight ratio of the extracting solution E2 to the polyglycerol monostearate is 1: 3, adding polyglycerol monostearate into the extract E2, and fully stirring for dissolving to obtain the propolis extract F.
(2) Preparing a white paeony root extract, a honeysuckle extract, a mangosteen extract, a salvia miltiorrhiza extract, a dandelion extract, a atractylodes rhizome extract and a poria cocos extract:
(a) respectively crushing radix paeoniae alba, honeysuckle, mangosteen, salvia miltiorrhiza, dandelion, rhizoma atractylodis and poria cocos into powder, adding the powder into a multifunctional extraction tank, and mixing the powder with water according to the weight ratio of 1: 7 decocting in water for 3 times, each time for 45 minutes, mixing decoctions, concentrating, adding ethanol while stirring, standing overnight for precipitation, filtering with 400 mesh filter cloth, and vacuum drying at 50 deg.C under-0.07 MPa to obtain radix Paeoniae alba extract, flos Lonicerae extract, fructus Garciniae extract, Saviae Miltiorrhizae radix extract, herba Taraxaci extract, rhizoma Atractylodis extract and Poria extract.
(3) Weighing the balance of water, dissolving soybean lecithin in water to prepare a lecithin solution, adding the white paeony root extract, the honeysuckle extract, the mangosteen extract, the salvia miltiorrhiza extract, the dandelion extract, the rhizoma atractylodis extract and the poria cocos extract in parts by weight respectively, and fully dissolving the materials by using a stirring homogenizer; finally adding propolis extract F to obtain the plant acne-removing composition.
Example 4
A plant acne-removing composition, 100 weight parts of which comprises 20.0 parts of propolis extract; 3.0 parts of white peony root extract; 4.0 parts of honeysuckle extract; 3.0 parts of mangosteen extract; 2.2 parts of salvia miltiorrhiza extract; 2.5 parts of dandelion extract; 2.5 parts of rhizoma atractylodis extract; 3.0 parts of poria cocos extract; 8.0 parts of soybean lecithin and the balance of water.
The rest of the procedure was the same as in example 3.
Example 5
A plant acne-removing composition, 100 parts by weight of which comprises the following raw materials: 15.0 parts of propolis extract; 1.5 parts of white peony root extract; 2.8 parts of honeysuckle extract; 2.2 parts of mangosteen extract; 1.5 parts of salvia miltiorrhiza extract; 1.7 parts of dandelion extract; 1.4 parts of rhizoma atractylodis extract; 2.3 parts of tuckahoe extract; 6.0 parts of soybean lecithin; the balance being water.
The rest of the procedure was the same as in example 3.
The plant acne-removing composition designed and prepared in the embodiment is proved by tests, and the embodiment 5 has a good effect on removing acnes, and the test effect is as follows.
Example 5 performance test of the prepared plant acne-removing composition:
high and low temperature stability test
The specific experimental method is as follows:
(i) the plant acne-removing composition prepared in the embodiment 5 is placed in an electric heating constant-temperature incubator at the temperature of 40-50 ℃ for 30-50 days, and then the stability of the plant acne-removing composition is observed after the temperature is restored to the room temperature;
(ii) the plant acne-removing composition prepared in the embodiment 5 is repeatedly heated or cooled for 15-30 days at the temperature of 0-50 ℃, and then the stability of the plant acne-removing composition is observed after the temperature is restored to the room temperature;
(iii) the plant acne-removing composition prepared in example 5 is stored at-5 ℃, room temperature and 40 ℃ for 3 times alternately, each time is 24 hours, namely, the plant acne-removing composition is stored at-5 ℃ for 24 hours, then is stored at room temperature for 24 hours, then is stored in a thermostat at 40 ℃ for 24 hours, and is circulated for 3 times in sequence, and the stability of the plant acne-removing composition is observed;
(iv) the stability was observed after 1 week storage at-5 ℃.
Secondly, measuring the hygienic performance index
(i) And (4) detecting the hygienic performance according to the standard of the hygienic standard of cosmetics, wherein the hygienic performance comprises the microbiological indexes of total bacterial colony, total mould and yeast, faecal coliform group, staphylococcus aureus and pseudomonas aeruginosa.
(ii) And (4) detecting the content of mercury, arsenic and lead according to the hygienic standard of the cosmetic hygiene standard.
(iii) Performing toxicology test and multiple skin irritation tests according to the standard of cosmetic hygiene standard.
The application method and the dosage of the plant acne-removing composition prepared in the example 5 are as follows: the ointment is directly applied to the affected part 3-5 times a day.
Three, result in
(1) High and low temperature stability test results:
the plant acne removing composition prepared in the example 5 has no phenomena of precipitation, fault, bleeding, coarse grains, fading and the like under different experimental conditions, and the experimental result shows that the plant acne removing composition prepared in the example 5 has good stability.
(2) Measurement result of hygienic property index
The microbial detection result is shown in figure 1, and the detection results of the hygienic chemical indexes of mercury, arsenic and lead are shown in figure 2, and the results show that the hygienic performance of the plant acne removing composition prepared in example 5 meets the hygienic standard of cosmetics; the results of the toxicology test and the multiple skin irritation test are shown in FIG. 3. The experimental result shows that the plant acne-removing composition prepared in example 5 has no irritation to the rabbit skin irritation test results for many times and has no other toxicity.
Example 5 clinical effect observation of the prepared plant acne-removing composition
150 patients with slight itching or pain and repeated difficult healing clinically manifested by acne, comedo, cyst type, pustule type and papular type whelk are selected and randomly divided into 3 groups of A group, B group and C group, wherein each group comprises 50 cases. Wherein group A patients did not apply any substance; group B is smeared with the plant acne-removing composition prepared in the example 5; group C smears commercially available dexamethasone.
The use method comprises the following steps: after cleaning the face every day, the corresponding medicine is smeared on the clinical manifestation part 3-5 times a day, and the statistics is carried out once every 3 days, 7 days and 1 month.
Evaluation criteria: (1) and (3) curing: disappearance of clinical symptoms, acne and regression of whelk; (2) the method has the following advantages: the clinical symptoms are relieved, and the acne part is eliminated or disappeared, less or reduced; (3) and (4) invalidation: the clinical symptoms of acne are not improved.
The trial result is shown in fig. 4, the plant acne removing composition prepared in example 5 has a clinical effect, and is quick in effect, the effective rate in 3 days and 7 days is more than 90%, the cure rate in 1 month is more than 88%, the effective rate in 3 days and 7 days in group C is about 84%, and the cure rate in 1 month is 78%.
Claims (5)
1. A plant acne-removing composition is characterized in that 100 parts by weight of the composition is composed of the following raw materials, 6-25 parts of propolis extract; 0.5-4.0 parts of white peony root extract; 1.0-5.0 parts of honeysuckle extract; 1.0-4.0 parts of mangosteen extract; 0.5-2.5 parts of salvia miltiorrhiza extract; 0.3-3.5 parts of dandelion extract; 0.5-3.0 parts of rhizoma atractylodis extract; 1.0-4.0 parts of poria cocos extract; 3.0-10.0 parts of soybean lecithin, and the balance of water; the plant acne-removing composition, the propolis extract, the white paeony root extract, the honeysuckle extract, the mangosteen extract, the salvia miltiorrhiza extract, the dandelion extract, the rhizoma atractylodis extract and the poria cocos extract in the plant acne-removing composition are prepared as follows:
(1) preparation of propolis extract:
(a) the ratio of propolis to ethyl acetate in ml is 1: 2-8, soaking and extracting the propolis at room temperature for 2-3 d, and then removing ethyl acetate from the separated extract through rotary evaporation to obtain a propolis extract E1, wherein the rotary evaporation is carried out at the temperature of 50-65 ℃;
(b) according to the ratio of the propolis extract E1 in grams to the polyethylene glycol in grams of 1: 4-8, and fully dissolving the mixture in a water bath kettle at the temperature of 75-85 ℃ to obtain an extracting solution E2;
(c) the weight ratio of the extracting solution E2 to the polyglycerol monostearate is 1: 2-4, adding polyglycerol monostearate into the extracting solution E2, and fully stirring and dissolving to obtain the propolis extract F;
(2) preparing a white paeony root extract, a honeysuckle extract, a mangosteen extract, a salvia miltiorrhiza extract, a dandelion extract, a atractylodes rhizome extract and a poria cocos extract:
respectively crushing radix paeoniae alba, honeysuckle, mangosteen, salvia miltiorrhiza, dandelion, rhizoma atractylodis and poria cocos into powder, adding the powder into a multifunctional extraction tank, and mixing the powder with water according to the weight ratio of 1: 4-10, decocting in water for 2-4 times, each time for 15-60 minutes, combining decoctions, concentrating, adding ethanol while stirring, precipitating overnight, filtering through 300-400 meshes of filter cloth, and vacuum drying to obtain a white paeony root extract, a honeysuckle flower extract, a mangosteen fruit extract, a salvia miltiorrhiza extract, a dandelion extract, a rhizoma atractylodis extract and a poria cocos extract respectively, wherein the vacuum drying is carried out at the temperature of 40-60 ℃ and the vacuum degree of-0.07-0.1 MPa;
(3) weighing the balance of water, dissolving soybean lecithin in water to prepare a lecithin solution, adding the white paeony root extract, the honeysuckle extract, the mangosteen extract, the salvia miltiorrhiza extract, the dandelion extract, the rhizoma atractylodis extract and the poria cocos extract in parts by weight respectively, and fully dissolving the materials by using a stirring homogenizer; finally adding propolis extract F to obtain the plant acne-removing composition.
2. The plant acne removal composition according to claim 1, wherein 100 parts by weight of the composition is prepared from the following raw materials: 10-20 parts of propolis extract; 1.2-3.0 parts of white peony root extract; 1.5-4.0 parts of honeysuckle extract; 1.5-3.0 parts of mangosteen extract; 0.8-2.2 parts of a salvia miltiorrhiza extract; 0.6-2.5 parts of dandelion extract; 1.0-2.5 parts of rhizoma atractylodis extract; 1.5-3.0 parts of poria cocos extract; 4.0-8.0 parts of soybean lecithin; the balance being water.
3. The plant acne removal composition according to claim 1, wherein 100 parts by weight of the composition is prepared from the following raw materials: 15.0 parts of propolis extract; 1.5 parts of white peony root extract; 2.8 parts of honeysuckle extract; 2.2 parts of mangosteen extract; 1.5 parts of salvia miltiorrhiza extract; 1.7 parts of dandelion extract; 1.4 parts of rhizoma atractylodis extract; 2.3 parts of tuckahoe extract; 6.0 parts of soybean lecithin; the balance being water.
4. The plant acne removal composition according to claim 1, wherein the particle size of radix paeoniae alba, honeysuckle, mangosteen, salvia miltiorrhiza, dandelion, atractylodes lancea and poria cocos is 100-200 meshes.
5. The plant acne removal composition according to claim 1, wherein the plant acne removal composition can be applied as a skin care topical.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810105071.6A CN108078903B (en) | 2018-02-02 | 2018-02-02 | A kind of plant acne-removing composition and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810105071.6A CN108078903B (en) | 2018-02-02 | 2018-02-02 | A kind of plant acne-removing composition and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108078903A CN108078903A (en) | 2018-05-29 |
| CN108078903B true CN108078903B (en) | 2021-04-16 |
Family
ID=62194264
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810105071.6A Active CN108078903B (en) | 2018-02-02 | 2018-02-02 | A kind of plant acne-removing composition and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108078903B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025083495A1 (en) * | 2023-10-19 | 2025-04-24 | Dyson Operations PTE. LTD. | Compositions for sebum control |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111374930A (en) * | 2018-12-28 | 2020-07-07 | 山东洁士医疗用品有限公司 | Natural plant asparagus mask essence and preparation method thereof |
| CN109568245A (en) * | 2019-02-14 | 2019-04-05 | 重庆市洲仨科技发展有限公司 | A kind of compound polyphenol anti-acne essence cream |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1685928A (en) * | 2005-05-08 | 2005-10-26 | 浙江大学 | Preparation method of nano propolis product |
| CN103263567A (en) * | 2013-05-24 | 2013-08-28 | 苏州谷力生物科技有限公司 | Acne-removing and face-cleaning composition and preparation method thereof |
| CN106726964A (en) * | 2016-12-26 | 2017-05-31 | 广西民族大学 | A kind of anti-acne facial cleanser |
| CN106726946A (en) * | 2016-12-21 | 2017-05-31 | 谢桂斌 | Deacne pack |
| CN106943435A (en) * | 2017-03-07 | 2017-07-14 | 浙江大学 | A kind of water-soluble bee glue and preparation method thereof |
| CN107412122A (en) * | 2017-05-05 | 2017-12-01 | 杭州蜂耘科技有限公司 | A kind of pure natural oral nursing liquid |
-
2018
- 2018-02-02 CN CN201810105071.6A patent/CN108078903B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1685928A (en) * | 2005-05-08 | 2005-10-26 | 浙江大学 | Preparation method of nano propolis product |
| CN103263567A (en) * | 2013-05-24 | 2013-08-28 | 苏州谷力生物科技有限公司 | Acne-removing and face-cleaning composition and preparation method thereof |
| CN106726946A (en) * | 2016-12-21 | 2017-05-31 | 谢桂斌 | Deacne pack |
| CN106726964A (en) * | 2016-12-26 | 2017-05-31 | 广西民族大学 | A kind of anti-acne facial cleanser |
| CN106943435A (en) * | 2017-03-07 | 2017-07-14 | 浙江大学 | A kind of water-soluble bee glue and preparation method thereof |
| CN107412122A (en) * | 2017-05-05 | 2017-12-01 | 杭州蜂耘科技有限公司 | A kind of pure natural oral nursing liquid |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025083495A1 (en) * | 2023-10-19 | 2025-04-24 | Dyson Operations PTE. LTD. | Compositions for sebum control |
Also Published As
| Publication number | Publication date |
|---|---|
| CN108078903A (en) | 2018-05-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN109078165B (en) | Composition for nursing female private parts and preparation method and application thereof | |
| CN102139030B (en) | Oral Chinese herbal preparation for treating gingivitis and preparation method thereof | |
| CN105168478A (en) | Skin care product and preparation method thereof | |
| CN103751725A (en) | Anti-inflammatory medicine with effects of sterilizing, removing acnes and whitening skin | |
| KR101128564B1 (en) | The manufacturing process of lithospermum erythrorhizon soap controlled by vineger | |
| CN108078903B (en) | A kind of plant acne-removing composition and preparation method thereof | |
| KR100867514B1 (en) | Manufacturing method of paper soap | |
| CN110522695A (en) | A kind of privates clean skin bath salt and preparation method and application | |
| CN103100075B (en) | Medicament for treating eczema | |
| KR101104898B1 (en) | Skin cleanser composition having an antimicrobial effect containing herbal extracts, such as fortified moth | |
| CN102415988B (en) | Wound healing gel and preparation process thereof | |
| CN113616774B (en) | Antibacterial composition containing plant stem cells, maintenance antibacterial liquid and preparation method thereof | |
| CN110787119A (en) | Antibacterial skin-care traditional Chinese medicine composition and preparation method and application thereof | |
| KR101034405B1 (en) | Cosmetic composition for improving acne skin | |
| CN108578465A (en) | A kind of Chinese medicine composition and its preparation method and application | |
| CN108186882A (en) | Skin bacteriostatic Chinese medicinal composition and preparation method thereof | |
| CN103920124B (en) | A kind of bactericidal skin care ointment for frostbite | |
| Pandey | A glimpse into the Indian traditional medicine with special reference to use of Hemidesmus indicus in Southern India: A review | |
| CN113662896A (en) | Plant-derived skin-care whole-body lotion and preparation method and application thereof | |
| CN104523922A (en) | External traditional Chinese medicine composition for acnes caused by heat toxin retention | |
| CN111686165A (en) | Pure traditional Chinese medicine composition for relieving itching of private parts, preparation and application of pure traditional Chinese medicine composition in cleaning private parts | |
| CN112190605A (en) | Antibacterial and anti-inflammatory composition and preparation method thereof | |
| CN105456849A (en) | Trauma caring composition with bacteria resisting, inhibiting and killing effects and preparation method of trauma caring composition | |
| CN109893494A (en) | A kind of light scar face mask of traditional Chinese medicine of anti-acne and preparation method thereof | |
| CN113663049B (en) | Li nationality medicine postpartum medicated bath effervescent granules and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20220811 Address after: Room 708, Building 1, Juhua Building, No. 6 Longzhou Road, Cangqian Street, Yuhang District, Hangzhou, Zhejiang 310000 Patentee after: HANGZHOU FENGQING TECHNOLOGY Co.,Ltd. Address before: 225300 No. 8 Fenghuang East Road, Hailing District, Taizhou City, Jiangsu Province Patentee before: Jiangsu Agri-animal Husbandry Vocational College |