JPH05320037A - Antioxidation agent - Google Patents

Abstract

PURPOSE:To provide an antioxidation agent having high safety and exhibiting remarkable antioxidation effect to give a cosmetic having strong skin-beautifying effect and effective in preventing the aging and chapping of the skin to keep the gloss and springiness of the skin. CONSTITUTION:At least one kind of herbs selected from KANJU (rhizome of Dryopteris crassirhizoma), SEKIRYUJUHI (bark of Punica granatum), SEKIRYUJIPPI (peel of Punica granatum), SEKIRYUKONPI (root skin of Punica granatum), BINROUJI (fruit of Areca catechu), TEPPOUKIN (root of Berchemia lineata), DAIOU (rhizome of Pheum palmatum), RYOKAOU (root skin of Wikstroemia indica), MAOU (stalk of Ephedra sinica), CHOUJI (bud of Syzygium aromatica) and SHINPI (bark of Fraxinus japonica) is extracted with water or a hydrophilic organic solvent such as ethanol, methanol or acetone, preferably water, ethanol or their mixture and the obtained extract is used as an essential component of the objective antioxidation agent having the above effects. Cosmetics having various forms such as lotion, cream, milky lotion or pack can be prepared by adding the antioxidation agent to other cosmetic raw materials. The solvent extract may be used in the form of freeze- dried powder.

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to a highly safe antioxidant.

[0002]

BACKGROUND OF THE INVENTION Butyl hydroxy anthony (BH
A), butylhydroxytoluene (BHT), vitamin E and its derivatives. BHA and BHT are synthetic products. As a general common sense nowadays, there is a strong criticism that the safety of long-term use of synthetic products is not guaranteed, and the use of synthetic products is being severely regulated even by actual laws and regulations. In addition, vitamin E and its derivatives have a weak antioxidant action, and a natural substance having a strong antioxidant action is desired.

[0003] Ganshu is a phylum of the genus Laminaria, Lagodonta, Subreticularis of the lamb, Oster of the genus Oster of the family Lepidoptera, Scientific name: Dryopteris crassiris reindeer.
hizoma NAKAI) etc. are dried rhizomes. It is used as an antipyretic, detoxifying, hemostasis, insecticide.

[0004] Stone bark, stone gall bark, and stone root bark are dicotyledonous nets, Lepidoptera, Pomegranates, pomegranates, scientific name Punica granatum L.
It is a dried product of bark, fruit bark or root bark. Pomegranate is native to Asia Minor and is a deciduous tree that has been cultivated in Japan for medicinal purposes or for appreciation since the Heian period. It is used as a parasite control and mouthwash.

Coleoptera is a dicotyledonous plant, a palm order, a palm family, areca of the genus Jinjuju, scientific name Areca catechu
Dried fruit of El (Areca catechu L.). Areca are distributed in southern China, Taiwan, and Malaysia, and are cultivated in tropical regions. Used as a stomachic, digestive, astringent, antiparasitic drug for indigestion, constipation, abdominal pain, and tapeworm control.

Iron metal is a dicotyledonous plant, a drowsiness eye,
Beechemia lichen, the genus Patricia, scientific name Bercheemia li
neata DC.) roots are dried. Himekumayanagi is distributed in the subtropics of Himalayas, India, Indochina, southern China, and Taiwan, and in Japan, it is a deciduous shrub that is somewhat eccentric to Amami Oshima and Ryukyu reefs. It is used for pulmonary tuberculosis, lung cancer, bruising, and sprains.

Liu Guang is a scientific name for the twin plant net, Lepidoptera, Lepidoptera, Gampi genus Wikstroemia indica CAMe.
y.) is the dried root bark. It is used as an antibacterial, diuretic and anti-inflammatory agent.

Daihuang is widely used as a medicine.
The purpose is as a colonic purgative, anti-inflammatory gastric drug, in Chinese medicine to eliminate toxic types of toxic type of people, promote profitability, breast filling, lodging,
It is a drug that cures abdominal pain and purulent swelling due to constipation, and is a raw material described in the Japanese Pharmacopoeia.

[0009] Clove is clove, scientific name Eugenya
It is called Eugenia caryophyllata or Syzygium aromaticum, and the dried flower buds of this tree are called cloves, or English cloves. It is widely used as a spice. On the other hand, it is also used as a medicine, and is applied as an aromatic stomachic agent to diseases such as splenic stomach chills, vomiting, vomiting, and abdominal pain.

Qin is a dicotyledonous net, a leaflet subnet, a moss, and a ash belonging to the genus Ashtonae (Satotonerico) Scientific name Fraxinus japonica (Fraxinus j
aponica), Aodamo (Fruxinus lanuginosa) scientific name, Fraxinus lanuginosa, and Species of Fraxinus rhynchophylla (Draconium rhynchophylla). All of them are dioecious deciduous trees, and because they are hard trees, they are used for guns, baseball bats, and the like.

[0011] Qin peel is also used as a medicinal product, which causes febrile diarrhea,
It has long been used as an antipyretic, eye wash, tonic, and anti-inflammatory agent. It has been used for a long time as an anti-inflammatory, anti-diarrheal, antipyretic and tonic.

[0012] Mao is a zoophyte, maou net, maou eye,
The aerial stalk of Ephedra sinica Stapf, whose scientific name is Ephedra sinica Stapf, is a dried aerial stalk of Ephedra sinica Stapf. Maou is native to Mongolia and northeastern China, and is a grass-like evergreen shrub that grows on sand. It is used as a sweat, antitussive, expectorant, for respiratory distress due to impaired excretion of the skin, asthma, chills, body pain, and joint pain.

[0013]

SUMMARY OF THE INVENTION It is an object of the present invention to provide antioxidants which are safe for application to the skin.

[0014]

[Means for Solving the Problems] In order to solve the above-mentioned problems, the present inventors have screened and investigated plants that have been used internally as pharmaceuticals for many years and have been confirmed to be safe for the human body, and have antioxidant properties. We examined what is useful as an agent. As a result, Ganshu, stone gall bark, gem bark, gem root bark, 榳 榔 子, iron envelop, rhubarb, 哥哥, 黄黄,
It was found that the solvent extract of Clove and Qin peel is very effective as an antioxidant.

That is, the present invention is at least one kind selected from the group consisting of ginseng, stone gall bark, gem bark, gem root bark, calyx, iron gauze, daihuang, ryeo, mahuang, thong, and huang skin. It is an antioxidant containing the solvent extract of.

[0016] Ganshu, stone gall bark, stone glazed skin, stone glazed root bark, 榳 抔 子, iron envelop, rhubarb, Ryoo King, mahuang, clove, Qin bark, water or hydrophilic organic solvent, for example, ethanol , Methanol, acetone, etc. However, it is natural that extraction with water, ethanol, or a mixed solvent thereof is preferable because it is extraction of cosmetic raw materials. In some cases, a polyhydric alcohol such as glycerin, 1,3 butylene glycol, propylene glycol or the like or a mixed liquid of polyhydric alcohol and water can be used for extraction. It is also effective to freeze-dry and use it as a powder depending on the method of use.

To this substance, other cosmetic ingredients such as liquid oils such as squalane and jojoba oil, solid oils such as beeswax and cetyl alcohol, various activators, humectants such as glycerin and 1,3 butylene glycol, and various agents are added. Thus, cosmetics of various dosage forms can be prepared. For example, a lotion, a cream, a milky lotion, a pack or the like may be used depending on the purpose.

[0018]

EXAMPLE An example which is an actual method of use will be described below, but the present invention is not limited to this example. Used in the present invention, stone bark, stone gall bark, stone gall bark, stone gall root bark, 榳 榔 子, iron metallurgical, Daihuang, Ryohao, Mao,
The following are examples of extracts of Choji and Qin peel.

(Example 1) 300 g of methanol was added to 10 g of a dried product, and the mixture was left for 5 days with occasional stirring. This was filtered and freeze-dried.

(Embodiment 2) The total amount of dried product is 5 g per 10 g.
300 ml of 0% aqueous methanol solution was added and the mixture was left for 5 days with occasional stirring. This was filtered and freeze-dried.

Example 3 300 g of purified water was added to 10 g of dried dried product and heated for 3 hours. This was allowed to cool, filtered, and then freeze-dried.

(Example 4) 10 g of stone gall bark (dry product)
300 ml of methanol was added to and the mixture was left for 5 days with occasional stirring. This was filtered and freeze-dried.

(Example 5) 10 g of stone gall bark (dry product)
300 ml of 50% aqueous methanol solution was added to the above and left for 5 days with occasional stirring. This was filtered and freeze-dried.

(Example 6) 10 g of stone gall bark (dry product)
300 ml of purified water is added to and heated for 3 hours. This was allowed to cool, filtered, and then freeze-dried.

(Embodiment 7) 10 g of stone glazed rind (dried product)
300 ml of purified water is added to and heated for 3 hours. This was allowed to cool, filtered, and then freeze-dried.

(Embodiment 8) 10 g of garlic root bark (dry product)
300 ml of methanol was added to and the mixture was left for 5 days with occasional stirring. This was filtered and freeze-dried.

(Example 9) 10 g of stone garlic bark (dry product)
300 ml of 50% aqueous methanol solution was added to the above and left for 5 days with occasional stirring. This was filtered and freeze-dried.

(Example 10) 10 stones of garlic root bark (dry product)
Add 300 ml of purified water to g and heat for 3 hours. This was allowed to cool, filtered, and then freeze-dried.

(Embodiment 11) 10 g of Reiko (dried product)
300 ml of methanol was added to and the mixture was left for 5 days with occasional stirring. This was filtered and freeze-dried.

(Embodiment 12) 10 g of garlic radix (dried product)
300 ml of 50% aqueous methanol solution was added to the above and left for 5 days with occasional stirring. This was filtered and freeze-dried.

(Embodiment 13) 10 g of garlic radix (dried product)
300 ml of purified water is added to and heated for 3 hours. This was allowed to cool, filtered, and then freeze-dried.

(Embodiment 14) Ten iron wrappings (dry products) were used.
300 g of an aqueous ethanol solution was added to g and left for 5 days with occasional stirring. This was filtered and freeze-dried.

(Example 15) 10 g of iron envelop (dry product)
To the solution was added 300 ml of 50% aqueous ethanol solution and the mixture was left for 5 days with occasional stirring. This was filtered and freeze-dried.

(Example 16) 10 g of iron packaging (dry product)
300 ml of 50% aqueous methanol solution was added to the above and left for 5 days with occasional stirring. This was filtered and freeze-dried.

(Example 17) 10 g of iron packaging (dry product)
300 ml of purified water is added to and heated for 3 hours. This was allowed to cool, filtered, and then freeze-dried.

(Example 18) 10 g of Ryogao (dry product)
Ethanol (300 ml) was added to the above and left for 5 days with occasional stirring. This was filtered and freeze-dried.

(Example 19) 10 g of Ryogao (dry product)
300 ml of 50% methanol solution was added to the above and left for 5 days with occasional stirring. This was filtered and freeze-dried.

Example 20 To 10 g of mahuang (dry product) was added 300 ml of methanol, and the mixture was left for 5 days with occasional stirring. This was filtered and freeze-dried.

Example 21 To 10 g of mahuang (dry product) was added 300 ml of 50% aqueous methanol solution, and the mixture was left for 5 days with occasional stirring. This was filtered and freeze-dried.

Example 22 To 10 g of mahuang (dry product) was added 300 ml of purified water and the mixture was heated for 3 hours. This was allowed to cool, filtered, and then freeze-dried.

Example 23 To 10 g of cloves (dried product) was added 300 ml of methanol and the mixture was left for 5 days with occasional stirring. This was filtered and freeze-dried.

Example 24 To 10 g of cloves (dried product) was added 300 ml of 50% aqueous methanol solution, and the mixture was left for 5 days with occasional stirring. This was filtered and freeze-dried.

Example 25 To 10 g of cloves (dried product) was added 300 ml of purified water and the mixture was heated for 3 hours. This was allowed to cool, filtered, and then freeze-dried.

(Example 26) 300 g of methanol was added to 10 g of large yellow (dry product), and the mixture was left for 5 days with occasional stirring. This was filtered and freeze-dried.

(Example 27) To 10 g of Daikon (dry matter) was added 300 ml of a 50% aqueous ethanol solution, and the mixture was left for 5 days with occasional stirring. This was filtered and freeze-dried.

(Example 28) To 10 g of Daikon (dry matter) was added 300 ml of 50% aqueous methanol solution, and the mixture was left for 5 days with occasional stirring. This was filtered and freeze-dried.

(Example 29) 300 g of purified water was added to 10 g of Rhubarb (dry product) and the mixture was heated for 3 hours. This was allowed to cool, filtered, and then freeze-dried.

(Example 30) To 10 g of Qin peel (dry product) was added 300 ml of 50% aqueous methanol solution, and the mixture was left for 5 days with occasional stirring. This was filtered and freeze-dried.

(Example 31) Purified water (300 ml) was added to 10 g of Qin peel (dry product), and the mixture was heated for 3 hours. This was allowed to cool, filtered, and then freeze-dried.

(Example 32) 10 g of Ryogao (dry product)
300 ml of purified water is added to and heated for 3 hours. This was allowed to cool, filtered, and then freeze-dried.

Example 33 Lotion Olive oil 0.5 Methanol extract of the common ingredients of Example 1 0.5 Polyoxyethylene (20 E.O.) sorbitan monostearate 2.0 Polyoxyethylene (60 E.O. ) Hydrogenated castor oil 2.0 Ethanol 10.0 1.0% sodium hyaluronate aqueous solution 5.0 Purified water 80.0

Example 34 Cream A Squalane 20.0 Olive Oil 2.0 Mink Oil 1.0 Jojoba Oil 5.0 Beeswax 5.0 Cetostearyl Alcohol 2.0 Glycerin Monostearate 1.0 Sorbitan Monostearate 2 0.0 50% methanol extract of the slurries of Example 2 1.0 B purified water 47.9 polyoxyethylene (20 E.O.) sorbitan monostearate 2.0 polyoxyethylene (60 E.O.) cured castor Oil 1.0 Glycerin 5.0 1.0% sodium hyaluronate aqueous solution 5.0 Methyl paraoxybenzoate 0.1 A and B are weighed and heated to 70 ° C., and A is gradually stirred into B. After adding, stirring slowly, 30
Cooled to ° C.

(Example 35) Example 35 is a lotion prepared by changing the extract of Example 1 of Example 33 into the extract of Example 3.

(Example 36) Example 36 is a cream prepared by replacing the extract of Example 2 of Example 34 with the extract of Example 4.

(Example 37) Example 37 is a lotion prepared by replacing the extract of Example 1 of Example 33 with the extract of Example 5.

(Example 38) Example 38 is a cream prepared by replacing the extract of Example 2 of Example 34 with the extract of Example 6.

(Example 39) Example 39 is a lotion prepared by replacing the extract of Example 1 of Example 33 with the extract of Example 7.

(Example 40) Example 40 is a cream prepared by replacing the extract of Example 2 of Example 34 with the extract of Example 8.

(Example 41) Example 41 is a lotion prepared by replacing the extract of Example 1 of Example 33 with the extract of Example 9.

(Example 42) Example 42 is a cream prepared by replacing the extract of Example 2 of Example 34 with the extract of Example 10.

(Example 43) Example 43 is a lotion prepared by replacing the extract of Example 1 of Example 33 with the extract of Example 11.

(Example 44) Example 44 is a cream prepared by replacing the extract of Example 2 of Example 34 with the extract of Example 12.

(Example 45) Example 45 is a lotion prepared by replacing the extract of Example 1 of Example 33 with the extract of Example 13.

(Example 46) Example 46 is a cream prepared by replacing the extract of Example 2 of Example 34 with the extract of Example 14.

(Example 47) Example 47 is a lotion prepared by replacing the extract of Example 1 of Example 33 with the extract of Example 15.

(Example 48) Example 48 is a cream prepared by replacing the extract of Example 2 of Example 34 with the extract of Example 16.

(Example 49) Example 49 is a lotion prepared by changing the extract of Example 1 of Example 33 into the extract of Example 17.

(Example 50) Example 50 is a cream prepared by replacing the extract of Example 2 of Example 34 with the extract of Example 18.

(Example 51) Example 51 is a lotion prepared by replacing the extract of Example 1 of Example 33 with the extract of Example 19.

(Example 52) Example 52 is a cream prepared by replacing the extract of Example 2 of Example 34 with the extract of Example 20.

(Example 53) Example 53 is a lotion prepared by replacing the extract of Example 1 of Example 33 with the extract of Example 21.

(Example 54) Example 54 is a cream prepared by replacing the extract of Example 2 of Example 34 with the extract of Example 22.

(Example 55) Example 55 is a lotion prepared by replacing the extract of Example 1 of Example 33 with the extract of Example 23.

(Example 56) Example 56 is a cream prepared by replacing the extract of Example 2 of Example 34 with the extract of Example 24.

(Example 57) Example 57 is a lotion prepared by replacing the extract of Example 1 of Example 33 with the extract of Example 25.

(Example 58) Example 58 is a cream prepared by replacing the extract of Example 2 of Example 34 with the extract of Example 26.

(Example 59) Example 59 is a lotion prepared by replacing the extract of Example 1 of Example 33 with the extract of Example 27.

(Example 60) Example 60 is a cream prepared by replacing the extract of Example 2 of Example 34 with the extract of Example 28.

(Example 61) Example 61 is a lotion prepared by replacing the extract of Example 1 of Example 33 with the extract of Example 29.

(Example 62) Example 62 is a cream prepared by replacing the extract of Example 2 of Example 34 with the extract of Example 30.

(Example 63) Example 63 is a lotion prepared by changing the extract of Example 1 of Example 33 into the extract of Example 31.

(Example 64) Example 64 is a cream prepared by replacing the extract of Example 2 of Example 34 with the extract of Example 32.

Antioxidant test The following test solutions were made into 50 ml test tubes with screw caps. Specimen 5 mg 2% ethanolic linoleic acid solution 10 ml 0.1 M, pH 7.0 phosphate buffer 10 ml purified water 5 ml This is left in a constant temperature bath at 50 ° C in the dark. The following measurements were taken before 3 days, 6 days, and 8 days before putting this in a constant temperature bath. Test solution 0.125 ml, 75% ethanol 12.1
25 ml, 30% ammonium thiocyanate 0.125 ml
Was added, stirred and left for 3 minutes, 0.125 ml of 0.02N ferrous chloride 3.5% HCl aqueous solution was added, stirred and left for 3 minutes, and the absorbance was measured at a wavelength of 500 nm. Cell length 10
mm, the control cell has the test solution replaced with water.

[0084]

[Table 1]

[0085]

[Table 2]

[0086]

[Table 3]

[0087]

[Table 4] Tables 1 to 4 show the antioxidative effects of single extracts such as ginseng and stone bark, but they have the same measurement characteristics, and therefore are additive to the mixture of two or more kinds. It has been confirmed that there are various effects, and therefore, a similar antioxidant effect is obtained for a mixture of two or more kinds.

Usage test Two women were divided into left and right faces, one of which was used as an example, and the other was used as a comparative example, which was used once or more daily.
Three months later, I did a questionnaire. In addition, in the comparative example, the extract in each of the examples is replaced with water. (Comparative Examples 1 and 2) 32 people were divided into 16 groups, and experiments were conducted using the samples shown in Table 5 below.

[Table 5] The criteria are as follows, and the results of the questionnaire are summarized in Table 6 below. Example is very good 3 Example is considerably good 2 Example is slightly good 1 No difference 0 Comparative example is good −1 Comparative example is good −2 Comparative example Is very good -3

[0089]

[Table 6]

[0090]

EFFECTS OF THE INVENTION Since the solvent extract of each plant of the present invention and the mixture thereof have a remarkable antioxidative effect, the cosmetics containing the same have a strong whitening effect, prevent skin aging, and prevent rough skin. Excellent effect to prevent and keep the skin glossy.

Front Page Continuation (72) Inventor Masao Hattori 2556-4-2 2-203 Gofuku Suehiro-cho, Toyama City, Toyama Prefecture (72) Inventor Kenji Shimomura 3-16-32 Funae, Ise City, Mie Prefecture 72 Inventor Masami Nakamura Mie Prefecture 6-32 Ikegami Town, Toba City

Claims (1)

[Claims] 1. Ganshu, stone gall bark, gypsum flesh, gypsum root bark,
Antioxidant containing at least one solvent extract selected from the group consisting of 榳 榔 子, iron wrapping, Daihoku, Ryoo, Mao, Ding, and Qin skin.