JPH05139951A - Face powder - Google Patents

Abstract

PURPOSE:To provide a cosmetic excellent in skin-whitening effect, also high in safety and stability. CONSTITUTION:The objective cosmetic formulated with an extract from at least one kind selected from Saxifragastolonifera Meerb., Aquillariaagallocha Roxburgh, Theasinensis L. var. viridis Szkzyl and Aesculushippocastanum L. The extract has high tyrosinase activity-inhibitory effect, decreasing melanin production through inhibiting the production of dopachrome from tyrosine. Furthermore, the cosmetic is excellent in safety and stability.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a whitening cosmetic composition containing a specific plant extract, which has excellent effects and is highly safe and stable.

[0002]

2. Description of the Related Art Whitening cosmetics have been of great interest in improving skin darkening, spots, freckles, etc., and ascorbic acid, glutathione, colloidal sulfur, etc. have been effective in them. It has been compounded as an ingredient.

There are also examples in which various medicinal plant extracts, plant-derived gallic acid, geraniin and the like are used. further,
Whitening ingredients such as kojic acid and arbutin, a glucopyranoside derivative, have also been used recently.

[0004]

However, ascorbic acid is liable to be oxidized and is unstable, and glutathione and colloidal sulfur have a drawback that they have a peculiar offensive odor and precipitation.

In addition, the conventional medicinal plant extracts have problems that the effect is not sufficient and the quality is not constant. Furthermore, it was necessary to consider maintaining the stability of kojic acid and the like. Besides,
In some cases, side effects occurred due to continuous use.

The present invention is intended to solve such problems and provide a whitening cosmetic composition which is excellent in whitening effect and which is highly stable and safe.

[0007]

[Means for Solving the Problems] Since cosmetics are continuously used every day, the active ingredient to be added to the cosmetics has a mild action, shows sufficient effects by continuous use, and has no side effect due to continuous use. Is desired. From such a viewpoint, a natural product-derived substance, particularly an extract of a medicinal plant, is preferable, but in order to solve the above-mentioned problems in effectiveness of the action, stability of quality, etc. From among them, those having an effective and mild skin lightening effect and having high stability were screened.

As a result, the saxifraga stolon
ifera Meerb.), Jinkou ( Aquillaria agallocha Rox
burgh), Oolongcha ( Thea sinensis L. var. virid
is Szkzyl) and horse chestnut ( Aesculus hippocastanum)
In the extract of L.), a high tyrosinase activity inhibitory effect was found. These extracts had no adverse effects on the skin such as skin irritation and sensitization, and when incorporated into cosmetics, the tyrosinase activity inhibitory action was not inactivated and the quality was stable.

Therefore, Yukinoshita ( Saxifraga stolonif
era Meerb.), Jinkou ( Aquillaria agallocha Roxbu
rgh), Oolongcha ( Thea sinensis L. var. viridis
Szkzyl) and horse chestnut ( Aesculus hippocastanum)
By blending one or two or more plant extracts selected from L.), a whitening cosmetic with a mild action and a sufficient whitening effect can be expected, and safety and stability are high. Came to do.

[0010]

The plant extract used in the present invention is generally 10 to 30 parts of dried or shredded fresh plant, an organic solvent such as ethanol or propylene glycol, or a mixture of these organic solvents, or Is obtained by adding 100 parts of a mixture of water and the above organic solvent, conducting extraction with stirring at room temperature for about 1 week, and then filtering to collect a filtrate. The whitening effect of these plant extracts was evaluated by the inhibition rate of tyrosinase activity. The evaluation was performed as follows.

First, 10 g of dried plant pieces were put in 100 ml of 50% by weight ethanol and extracted at room temperature for 1 week. This plant extract was diluted 100-fold with purified water to prepare a sample solution. Next, tyrosinase (50,000
units, manufactured by Sigma) were diluted 600 times with purified water to obtain an enzyme solution. The substrate solution was prepared by dissolving 50 mg of tyrosine in 100 ml of purified water.

The enzyme reaction was carried out using a sample solution of 2 ml, 1 / 15M.
Phosphate buffer (pH 6.8) 2 ml, substrate solution 0.5 m
1 and 0.5 ml of the enzyme solution were mixed and incubated at 37 ° C. for 1 hour. After the reaction, the absorbance (As) at 475 nm was measured. Further, the same reaction was carried out in a system in which purified water was added instead of the sample solution and a system in which purified water was added instead of the substrate solution, and the absorbance (Ab and A0) in each case was measured. The tyrosinase activity inhibition rate was calculated by the equation 1.

[Equation 1]

The measurement results are shown in Table 1. As is clear from Table 1, each of the plant extracts used in the present invention exhibits a significantly high tyrosinase activity inhibitory rate, reduces the production of dopachrome from tyrosine, and exerts an effective whitening effect. Was shown. Among them, Yukinoshita ( Saxi
The extract of fraga stolonifera Meerb.) showed a high tyrosinase activity inhibition rate of 82.8% and had a particularly excellent whitening effect.

[Table 1]

In the present invention, the blending amount of the above plant extract in the whitening cosmetic is appropriately 0.001 to 20% by weight. If the blending amount is 0.001% by weight or less, a sufficient whitening effect cannot be obtained, but since the whitening effect is quite strong, it is not necessary to blend it in a too large amount. Can also affect.

Further, the whitening cosmetic composition according to the present invention is a softening lotion, astringent lotion, lotion such as cleansing lotion, emollient cream, moisturizing cream, massage cream, cleansing cream, makeup cream, etc. Creams, emollient emulsions, moisturizing emulsions, nourishing emulsions, cleansing emulsions and other emulsions,
Various formulation forms such as packs such as jelly-like packs, pail-off packs, powder-like packs, and face wash can be used.

Furthermore, other active ingredients such as moisturizers, anti-inflammatory agents, and ultraviolet absorbers can be used in combination, and sunscreen cosmetics, skin protective cosmetics, rough skin improving cosmetics and other medicated cosmetics or It can also be provided as a quasi drug.

[0017]

EXAMPLES Next, the present invention will be described in more detail by way of examples.

Example 1 is a whitening cream according to the present invention. The prescription is shown in Table 2. In Table 2, (1) to (7) were heated and dissolved at 75 ° C, (10) to (13) heated and dissolved at 75 ° C were added to emulsify, and the mixture was cooled at 50 ° C (8). , (9) are added and further cooled to obtain a whitening cream.

[Table 2]

Example 2 is a whitening emulsion according to the present invention.
The prescription is shown in Table 3. In Table 3, (1) to (8) were heated and dissolved at 75 ° C., and (12) to (16) which was heated and dissolved at 75 ° C. were added to emulsify, and the mixture was cooled at 50 ° C. (9). )-(11) are added and further cooled to obtain a whitening emulsion.

[Table 3]

Comparative Example 1 was the same as Example 1, except that the extract of (9) Yukinoshita was removed and the total amount was 100% by weight with purified water. Similarly, Comparative Example 2 was the same as Example 2 except that the ginkgo extract of (10) and the horse chestnut extract of (11) were removed and the total amount was 100% by weight with purified water.

Using the above examples and comparative examples, use tests were conducted to evaluate the whitening effect. In the use test, 40 female panelists aged 30 to 40 years old who are worried about stains and freckles are randomly divided into 4 groups of 10 persons, and Examples 1 and 2 and Comparative Examples 1 and 2 are blinded in each group. I went to use it.
After washing the face twice daily in the morning and at night, an appropriate amount of the sample was applied to the face and the use was continued for 2 weeks. The whitening effect was evaluated by observing the condition of facial spots and freckles after the use test. The results are shown in Table 4.

[Table 4]

In Table 4, in the group using Example 1, improvement in spots and freckles was observed in 8 subjects, and the remaining 2
The name also showed some improvement. The effective rate for improving spots and freckles was 100%. Even in the use group of Example 2, one patient did not see any improvement in spots and freckles, but the efficacy rate was 90%. In 6 of them, remarkable improvement of spots and freckles was observed. On the other hand, in the group using Comparative Example 1, none of the panelists recognized an improvement in spots and freckles. In the group using Comparative Example 2, a small amount of the ascorbic acid derivative was used, so that a slight improvement was observed in one subject, but no improvement was observed in the remaining nine subjects.

In addition, the whitening cream of Example 1 contains a Yukinoshita extract having a high tyrosinase activity-inhibiting effect, and also has an effect of improving spots and freckles in the use test by using the Ginkgo extract and the horse chestnut extract in combination. It was at least as high as in Example 2.

Further, no panelists complained of skin irritation such as pain and itch or skin disorders such as allergic reaction in any of the groups used in the above-mentioned use test period. Further, no deterioration of the quality of the cosmetic such as sedimentation and deterioration of the blended components was observed.

[0025]

As described above, according to the present invention, it is possible to provide a whitening cosmetic composition which exhibits an effective whitening effect and is excellent in stability and safety.

Claims (1)

[Claims] 1. Yukinoshita ( Saxifraga stolonifera Me
erb.), Jinkou ( Aquillaria agallocha Roxburg
h), Oolongcha ( Thea sinensis L. var. viridis S
zkzyl) and horse chestnut ( Aesculus hippocastanum L.)
A whitening cosmetic characterized in that it contains one or more plant extracts selected from the above.