JPH06199647A - Skin beautifying cosmetic - Google Patents

Skin beautifying cosmetic

Info

Publication number
JPH06199647A
JPH06199647A JP4361633A JP36163392A JPH06199647A JP H06199647 A JPH06199647 A JP H06199647A JP 4361633 A JP4361633 A JP 4361633A JP 36163392 A JP36163392 A JP 36163392A JP H06199647 A JPH06199647 A JP H06199647A
Authority
JP
Japan
Prior art keywords
extract
whitening
skin beautifying
cosmetics
skin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP4361633A
Other languages
Japanese (ja)
Inventor
Kumiko Sekihara
くみこ 関原
Hitoshi Masaki
仁 正木
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Noevir Co Ltd
Original Assignee
Noevir Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Noevir Co Ltd filed Critical Noevir Co Ltd
Priority to JP4361633A priority Critical patent/JPH06199647A/en
Publication of JPH06199647A publication Critical patent/JPH06199647A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE:To provide a skin beautifying cosmetic having excellent beautifying effect, high safety and high stability. CONSTITUTION:The objective skin beautifying cosmetic is produced by compounding extract of Melissaofficinalis and/or extract of Thymusvulgaris. The vegetable extract have high inhibitor action to tyrosinase activity and reduce the production of melanin by suppressing dopachrome formation from tyrosine. They are also excellent in safety and stability in cosmetics.

Description

【発明の詳細な説明】Detailed Description of the Invention

【0001】[0001]

【産業上の利用分野】本発明は、特定の植物抽出物を配
合して成る、美白効果に優れ、且つ安全性及び安定性の
高い美白化粧料に関する。
BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a whitening cosmetic composition containing a specific plant extract, which has an excellent whitening effect and is highly safe and stable.

【0002】[0002]

【従来の技術】従来より、皮膚の色黒,シミ,ソバカス
等を改善する上で、美白化粧料は非常に関心の深いもの
であり、これらにおいては、アスコルビン酸,グルタチ
オン,コロイドイオウ等が有効成分として配合されてき
た。
2. Description of the Prior Art Whitening cosmetics have been of great interest in improving skin darkness, spots, freckles, etc., and ascorbic acid, glutathione, colloidal sulfur, etc. have been effective in them. It has been compounded as an ingredient.

【0003】また、種々の薬用植物抽出物や、植物由来
の没食子酸,ゲラニイン等を用いた例もある。さらに、
コウジ酸やグルコピラノシド誘導体であるアルブチンと
いった美白成分も最近使用されている。
There are also examples in which various medicinal plant extracts, plant-derived gallic acid, geraniin and the like are used. further,
Whitening ingredients such as kojic acid and arbutin, a glucopyranoside derivative, have also been used recently.

【0004】[0004]

【発明が解決しようとする課題】しかしながら、アスコ
ルビン酸は酸化されやすく不安定であり、グルタチオン
やコロイドイオウは、特有の異臭や沈澱が生じるという
欠点を有する。
However, ascorbic acid is liable to be oxidized and is unstable, and glutathione and colloidal sulfur have a drawback that they have a peculiar offensive odor and precipitation.

【0005】また、従来の薬用植物抽出物は効果が今一
つ不十分であったり、品質が一定しないといった問題点
があった。さらに、コウジ酸等においても、その安定性
の維持等に配慮しなければならなかった。その他にも、
連用により副作用の発生するものもあった。
In addition, the conventional medicinal plant extracts have problems that the effect is insufficient and the quality is not constant. Furthermore, it was necessary to consider maintaining the stability of kojic acid and the like. Besides,
In some cases, side effects occurred due to continuous use.

【0006】本発明は、かかる課題を解決し、美白効果
に優れ、且つ安定性及び安全性の高い美白化粧料を提供
せんとするものである。
The present invention is intended to solve the above problems and provide a whitening cosmetic composition which is excellent in whitening effect and which is highly stable and safe.

【0007】[0007]

【課題を解決するための手段】化粧料は毎日連用される
ものであるため、これに配合する有効成分としては、作
用が穏和で連用により十分な効果を現わし、しかも連用
による副作用のないものが望まれる。かかる観点から
は、天然物由来物質、特に薬用植物の抽出物が好ましい
ものであるが、上記した作用の有効性,品質の安定性等
における問題点を解決するため、われわれは、植物抽出
物の中から、有効且つ穏和な皮膚美白作用を有し、さら
に安定性も高いものをスクリーニングした。
[Means for Solving the Problems] Since cosmetics are continuously used every day, the active ingredient to be added to the cosmetics should be mild in action, exhibit sufficient effect by continuous use, and have no side effect due to continuous use. Is desired. From such a viewpoint, a natural product-derived substance, particularly an extract of a medicinal plant is preferable, but in order to solve the above-mentioned problems in effectiveness of the action, stability of quality, etc. From among them, those having an effective and mild skin whitening effect and having high stability were screened.

【0008】その結果、レモンバーム(Melissa offici
nalis)及びタイム(Thymus vulgaris)の抽出物におい
て、高いチロシナーゼ活性阻害効果を見い出した。これ
らの抽出物においては、皮膚刺激性,接触感作性といっ
た皮膚への悪影響もなく、また化粧料に配合したとき
も、チロシナーゼ活性阻害作用の不活化は起こらず、品
質も安定していた。
As a result, lemon balm ( Melissa offici)
A high tyrosinase activity inhibitory effect was found in extracts of nalis ) and thyme ( Thymus vulgaris ). These extracts had no adverse effects on the skin such as skin irritation and contact sensitization, and when incorporated into cosmetics, the tyrosinase activity inhibitory action was not inactivated and the quality was stable.

【0009】従って、レモンバーム(Melissa officina
lis)及び/叉はタイム(Thymus vulgaris)の抽出物を
配合することにより、作用が穏和で且つ十分な美白効果
が期待でき、しかも安全性,安定性の高い美白化粧料を
完成するに至った。
Therefore, lemon balm ( Melissa officina
lis ) and / or thyme ( Thymus vulgaris ) extract was added, and a whitening cosmetic composition with a mild action and a sufficient whitening effect and high safety and stability was achieved. .

【0010】[0010]

【作用】本発明において使用する上記植物の抽出物は、
一般的には乾燥或いは生植物を細切したもの10〜30
部に、エタノール,プロピレングリコール等の有機溶媒
もしくはこれらの有機溶媒の混合物、叉は水と上記有機
溶媒との混合物100部を加えて、室温にて約1週間攪
拌しながら抽出を行った後、ろ過して、ろ液を採取して
得る。これら植物抽出物の美白効果を、チロシナーゼ活
性の阻害率により評価した。評価は次のようにして行っ
た。
The above plant extract used in the present invention is
Generally, dried or shredded fresh plants 10-30
100 parts of a mixture of an organic solvent such as ethanol or propylene glycol or a mixture of these organic solvents, or a mixture of water and the above organic solvent, was added to the parts, and the mixture was extracted at room temperature for about 1 week with stirring, It is obtained by filtering and collecting the filtrate. The whitening effect of these plant extracts was evaluated by the inhibition rate of tyrosinase activity. The evaluation was performed as follows.

【0011】まず、乾燥した植物細片10gを50重量
%エタノール100ml中に入れ、室温で1週間抽出を
行った。この植物抽出物を精製水にて100倍希釈して
試料溶液を調製した。次に、チロシナーゼ(50000
units,シグマ社製)を精製水で600倍希釈して、酵
素溶液とした。基質溶液は、チロシン50mgを精製水
100mlに溶解して調製した。
First, 10 g of dried plant pieces were put in 100 ml of 50% by weight ethanol and extracted at room temperature for 1 week. This plant extract was diluted 100-fold with purified water to prepare a sample solution. Next, tyrosinase (50,000
units, manufactured by Sigma) were diluted 600 times with purified water to obtain an enzyme solution. The substrate solution was prepared by dissolving 50 mg of tyrosine in 100 ml of purified water.

【0012】酵素反応は、試料溶液2ml,1/15M
リン酸緩衝液(pH6.8)2ml,基質溶液0.5m
l,酵素溶液0.5mlを混合し、37℃にて1時間イ
ンキュベートして行わせた。反応後、475nmにおけ
る吸光度(As)を測定した。さらに、試料溶液の代わ
りに精製水を添加した系,及び基質溶液の代わりに精製
水を添加した系において同様に反応させ、それぞれの場
合における吸光度(Ab及びA0)を測定した。チロシナ
ーゼ活性阻害率は、数1により求めた。
The enzyme reaction was carried out using a sample solution of 2 ml, 1 / 15M.
Phosphate buffer (pH 6.8) 2 ml, substrate solution 0.5 m
1 and 0.5 ml of the enzyme solution were mixed and incubated at 37 ° C. for 1 hour. After the reaction, the absorbance (As) at 475 nm was measured. Further, the same reaction was carried out in a system in which purified water was added instead of the sample solution and a system in which purified water was added instead of the substrate solution, and the absorbance (Ab and A0) in each case was measured. The tyrosinase activity inhibition rate was calculated by the equation 1.

【数1】 [Equation 1]

【0013】測定結果を表1に示した。表1より明らか
なように、本発明で使用する植物抽出物は、いずれも有
意に高いチロシナーゼ活性阻害率を示し、チロシンから
のドーパクロムの生成を低下させて、有効な美白効果を
発揮するものであった。
The measurement results are shown in Table 1. As is clear from Table 1, all the plant extracts used in the present invention show a significantly high tyrosinase activity inhibition rate, reduce the production of dopachrome from tyrosine, and exhibit an effective whitening effect. there were.

【表1】 [Table 1]

【0014】本発明において、美白化粧料への上記植物
抽出物の配合量は0.001〜20重量%が適当であ
る。配合量が0.001重量%以下であると十分な美白
効果が得られないが、美白作用がかなり強いため、あま
り多量に配合する必要もなく、20重量%を超えると化
粧料の安定性等に影響を及ぼすこともある。
In the present invention, the blending amount of the above plant extract in the whitening cosmetic is appropriately 0.001 to 20% by weight. If the blending amount is 0.001% by weight or less, a sufficient whitening effect cannot be obtained, but since the whitening effect is quite strong, it is not necessary to blend it in a too large amount. Can also affect.

【0015】また、本発明に係る美白化粧料は、柔軟性
化粧水,収斂性化粧水,洗浄用化粧水等の化粧水類、エ
モリエントクリーム,モイスチュアクリーム,マッサー
ジクリーム,クレンジングクリーム,メイクアップクリ
ーム等のクリーム類、エモリエント乳液,モイスチュア
乳液,ナリシング乳液,クレンジング乳液等の乳液類、
ゼリー状パック,ピールオフパック,粉末状パック等の
パック類、及び洗顔料類といった種々の製剤形態とする
ことができる。
Further, the whitening cosmetic composition according to the present invention is a softening lotion, astringent lotion, lotion such as cleansing lotion, emollient cream, moisturizing cream, massage cream, cleansing cream, makeup cream, etc. Creams, emollient emulsions, moisturizing emulsions, nourishing emulsions, cleansing emulsions and other emulsions,
Various formulation forms such as jelly packs, peel-off packs, packs such as powdery packs, and face wash can be prepared.

【0016】さらに、保湿剤,抗炎症剤,紫外線吸収剤
等の他の有効成分を併用することもでき、日焼け止め化
粧料,皮膚保護用化粧料,荒れ肌改善用化粧料等の薬用
化粧料或いは医薬部外品等として提供することもでき
る。
Furthermore, other active ingredients such as moisturizers, anti-inflammatory agents, and ultraviolet absorbers can be used in combination, and sunscreen cosmetics, skin protective cosmetics, rough skin improving cosmetics and other medicated cosmetics or It can also be provided as a quasi drug.

【0017】[0017]

【実施例】次に、本発明を実施例によりさらに詳細に説
明する。
EXAMPLES Next, the present invention will be described in more detail by way of examples.

【0018】実施例1は本発明に係る美白クリームであ
る。処方を表2に示す。表2中、(1)〜(7)を75℃に加
熱溶解し、これに75℃に加熱溶解した(10)〜(13)を加
えて乳化し、冷却して50℃にて(8),(9)を添加し、さ
らに冷却して美白クリームとする。
Example 1 is a whitening cream according to the present invention. The prescription is shown in Table 2. In Table 2, (1) to (7) were heated and dissolved at 75 ° C, (10) to (13) heated and dissolved at 75 ° C were added to emulsify, and the mixture was cooled at 50 ° C (8). , (9) are added and further cooled to obtain a whitening cream.

【表2】 [Table 2]

【0019】実施例2は本発明に係る美白乳液である。
処方を表3に示す。表3中、(1)〜(8)を75℃に加熱溶
解し、これに75℃に加熱溶解した(11)〜(15)を添加し
て乳化し、冷却して50℃にて(9)〜(10)を添加し、さ
らに冷却して美白乳液とする。
Example 2 is a whitening emulsion according to the present invention.
The prescription is shown in Table 3. In Table 3, (1) to (8) were heated and dissolved at 75 ° C, (11) to (15) heated and dissolved at 75 ° C were added and emulsified, and the mixture was cooled at 50 ° C (9). )-(10) are added and further cooled to obtain a whitening emulsion.

【表3】 [Table 3]

【0020】実施例1において、(9)のレモンバーム抽
出物を除去し、精製水で全量を100重量%としたもの
を比較例1とした。同様に、実施例2において、(10)の
タイム抽出物を除去し、精製水で全量を100重量%と
したものを比較例2とした。
Comparative Example 1 was prepared by removing the lemon balm extract of (9) in Example 1 and adjusting the total amount to 100% by weight with purified water. Similarly, Comparative Example 2 was prepared by removing the thyme extract (10) in Example 2 and adjusting the total amount to 100% by weight with purified water.

【0021】上記の実施例及び比較例について、使用試
験を行って美白効果を評価した。使用試験は、シミ,ソ
バカスの気になる30〜40才の女性パネラー40名を
無作為に10名ずつ4群に分け、実施例1,2、及び比
較例1,2をブラインドにて各群に使用させて行った。
毎日朝と夜の2回、洗顔後に試料の適量を顔面に塗布さ
せ、2月間使用を継続させた。美白効果は、使用試験終
了後の顔面のシミ,ソバカスの状態を観察して評価し
た。結果を表4に示す。
Using the above examples and comparative examples, use tests were conducted to evaluate the whitening effect. In the use test, 40 female panelists aged 30 to 40 years old who are worried about stains and freckles are randomly divided into 4 groups of 10 persons, and Examples 1 and 2 and Comparative Examples 1 and 2 are blinded in each group. I went to use it.
After washing the face twice daily in the morning and at night, an appropriate amount of the sample was applied to the face and the use was continued for 2 months. The whitening effect was evaluated by observing the condition of facial spots and freckles after the use test. The results are shown in Table 4.

【表4】 [Table 4]

【0022】表4において、実施例1を使用した群で
は、9名においてシミ,ソバカスの改善を認め、残る1
名においても若干の改善が認められた。シミ,ソバカス
の改善における有効率は100%であった。実施例2の
使用群においても、8名においてシミ,ソバカスの改善
がみられ、残る2名についてもやや改善されており、シ
ミ,ソバカスの改善における有効率は同様に100%で
あった。一方、比較例1使用群では、シミ,ソバカスの
改善を認めたパネラーはいなかった。また、比較例2使
用群においては、アスコルビン酸誘導体を少量用いてい
るので若干1名に多少の改善がみられたが、残る9名に
おいては改善は認められなかった。
In Table 4, in the group using Example 1, improvement in spots and freckles was observed in 9 subjects, and the remaining 1
The name also showed some improvement. The effective rate for improving spots and freckles was 100%. Also in the use group of Example 2, improvement in spots and freckles was observed in 8 subjects, and slight improvement in the remaining 2 subjects, and the efficacy rate in improving spots and freckles was also 100%. On the other hand, in the group using Comparative Example 1, none of the panelists recognized an improvement in spots and freckles. In the group using Comparative Example 2, a small amount of the ascorbic acid derivative was used, so that a slight improvement was observed in one subject, but no improvement was observed in the remaining nine subjects.

【0023】さらに、上記の使用試験期間において、い
ずれの実施例を使用した群においても、痛み,かゆみ等
の皮膚刺激やアレルギー反応等の皮膚障害を訴えたパネ
ラーはいなかった。また、配合成分の沈降,変質等の化
粧料の品質の低下もみられなかった。
Further, no panelists complained of skin irritation such as pain and itch or skin disorders such as allergic reaction in any of the groups used in the above-mentioned use test period. Further, no deterioration of the quality of the cosmetic such as sedimentation and deterioration of the blended components was observed.

【0024】[0024]

【発明の効果】以上のように、本発明により、有効な美
白効果を示し、且つ安定性及び安全性に優れる美白化粧
料を提供することができた。
As described above, according to the present invention, it is possible to provide a whitening cosmetic composition which exhibits an effective whitening effect and is excellent in stability and safety.

Claims (1)

【特許請求の範囲】[Claims] 【請求項1】 レモンバーム(Melissa officinalis
及び/叉はタイム(Thymus vulgaris) の抽出物を配合
することを特徴とする、美白化粧料。
1. Lemon balm ( Melissa officinalis )
And / or a whitening cosmetic characterized in that it contains an extract of Thymus vulgaris .
JP4361633A 1992-12-28 1992-12-28 Skin beautifying cosmetic Pending JPH06199647A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP4361633A JPH06199647A (en) 1992-12-28 1992-12-28 Skin beautifying cosmetic

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4361633A JPH06199647A (en) 1992-12-28 1992-12-28 Skin beautifying cosmetic

Publications (1)

Publication Number Publication Date
JPH06199647A true JPH06199647A (en) 1994-07-19

Family

ID=18474358

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4361633A Pending JPH06199647A (en) 1992-12-28 1992-12-28 Skin beautifying cosmetic

Country Status (1)

Country Link
JP (1) JPH06199647A (en)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10175842A (en) * 1996-12-13 1998-06-30 Noevir Co Ltd Skin preparation for external use
JPH10182333A (en) * 1996-12-20 1998-07-07 Noevir Co Ltd Antimicrobial and low-irritation cosmetic
JPH11349435A (en) * 1998-06-03 1999-12-21 Noevir Co Ltd Skin agent used for external use and effective for preventing and improving pigmentary symptom caused by ultraviolet light
JP2002114668A (en) * 2000-10-11 2002-04-16 Noevir Co Ltd Skin care preparation
JP2003137762A (en) * 2001-11-01 2003-05-14 Noevir Co Ltd Skin care preparation
JP2004043514A (en) * 2003-11-14 2004-02-12 Noevir Co Ltd Endothelin-1 inhibitor
US7485327B2 (en) * 2000-12-12 2009-02-03 Angiolab, Inc. Composition comprising Melissa leaf extract for anti-angiogenic and matrix metalloproteinase inhibitory activity
JP2010168337A (en) * 2008-12-22 2010-08-05 Pola Chem Ind Inc External preparation for skin containing hydroxycarboxylic acid derivative
JP2011068572A (en) * 2009-09-24 2011-04-07 Pola Chemical Industries Inc Phagocytosis inhibitor
KR101282335B1 (en) * 2010-01-29 2013-07-05 고려대학교 산학협력단 Compositions comprising an extract of lemon balm for skin-whitening effect
US9155773B2 (en) 2001-12-12 2015-10-13 Angiolab, Inc. Antiobesity composition
JP2020164490A (en) * 2019-03-29 2020-10-08 丸善製薬株式会社 Melissa officinalis fermented liquid and manufacturing method thereof as well as cosmetics
JP2020164486A (en) * 2019-03-29 2020-10-08 丸善製薬株式会社 Anti-aging agents, antioxidants, anti-inflammatory agents, and whitening agents, as well as cosmetics
JP2020164489A (en) * 2019-03-29 2020-10-08 丸善製薬株式会社 Thymus vulgaris fermented liquid, method for producing the same, and cosmetic
CN114152688A (en) * 2021-11-23 2022-03-08 华中农业大学 Method for screening characteristic marker from bee pollen extract and application of characteristic marker in identification of bee pollen

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10175842A (en) * 1996-12-13 1998-06-30 Noevir Co Ltd Skin preparation for external use
JPH10182333A (en) * 1996-12-20 1998-07-07 Noevir Co Ltd Antimicrobial and low-irritation cosmetic
JPH11349435A (en) * 1998-06-03 1999-12-21 Noevir Co Ltd Skin agent used for external use and effective for preventing and improving pigmentary symptom caused by ultraviolet light
JP2002114668A (en) * 2000-10-11 2002-04-16 Noevir Co Ltd Skin care preparation
US7485327B2 (en) * 2000-12-12 2009-02-03 Angiolab, Inc. Composition comprising Melissa leaf extract for anti-angiogenic and matrix metalloproteinase inhibitory activity
JP2003137762A (en) * 2001-11-01 2003-05-14 Noevir Co Ltd Skin care preparation
US9155773B2 (en) 2001-12-12 2015-10-13 Angiolab, Inc. Antiobesity composition
JP2004043514A (en) * 2003-11-14 2004-02-12 Noevir Co Ltd Endothelin-1 inhibitor
JP2010168337A (en) * 2008-12-22 2010-08-05 Pola Chem Ind Inc External preparation for skin containing hydroxycarboxylic acid derivative
JP2011068572A (en) * 2009-09-24 2011-04-07 Pola Chemical Industries Inc Phagocytosis inhibitor
KR101282335B1 (en) * 2010-01-29 2013-07-05 고려대학교 산학협력단 Compositions comprising an extract of lemon balm for skin-whitening effect
JP2020164490A (en) * 2019-03-29 2020-10-08 丸善製薬株式会社 Melissa officinalis fermented liquid and manufacturing method thereof as well as cosmetics
JP2020164486A (en) * 2019-03-29 2020-10-08 丸善製薬株式会社 Anti-aging agents, antioxidants, anti-inflammatory agents, and whitening agents, as well as cosmetics
WO2020203933A1 (en) * 2019-03-29 2020-10-08 丸善製薬株式会社 Antiaging agent, antioxidant, antiinflammatory agent and whitening agent, and cosmetic
JP2020164489A (en) * 2019-03-29 2020-10-08 丸善製薬株式会社 Thymus vulgaris fermented liquid, method for producing the same, and cosmetic
CN113631227A (en) * 2019-03-29 2021-11-09 丸善制药株式会社 Antiaging agent, antioxidant, antiinflammatory agent, whitening agent, and cosmetic
CN114152688A (en) * 2021-11-23 2022-03-08 华中农业大学 Method for screening characteristic marker from bee pollen extract and application of characteristic marker in identification of bee pollen
CN114152688B (en) * 2021-11-23 2023-07-04 华中农业大学 Method for screening characteristic markers from bee pollen extract and application thereof

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