JPH0587482B2 - - Google Patents
Info
- Publication number
- JPH0587482B2 JPH0587482B2 JP58209545A JP20954583A JPH0587482B2 JP H0587482 B2 JPH0587482 B2 JP H0587482B2 JP 58209545 A JP58209545 A JP 58209545A JP 20954583 A JP20954583 A JP 20954583A JP H0587482 B2 JPH0587482 B2 JP H0587482B2
- Authority
- JP
- Japan
- Prior art keywords
- whitening
- cream
- present
- extract
- cosmetics
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000002087 whitening effect Effects 0.000 claims description 25
- 239000002537 cosmetic Substances 0.000 claims description 16
- 239000000419 plant extract Substances 0.000 claims description 13
- 244000130592 Hibiscus syriacus Species 0.000 claims description 3
- 235000018081 Hibiscus syriacus Nutrition 0.000 claims description 3
- 240000004385 Centaurea cyanus Species 0.000 claims description 2
- 235000005940 Centaurea cyanus Nutrition 0.000 claims description 2
- 235000009917 Crataegus X brevipes Nutrition 0.000 claims description 2
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 claims description 2
- 235000009685 Crataegus X maligna Nutrition 0.000 claims description 2
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 claims description 2
- 235000009486 Crataegus bullatus Nutrition 0.000 claims description 2
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 claims description 2
- 235000009682 Crataegus limnophila Nutrition 0.000 claims description 2
- 235000004423 Crataegus monogyna Nutrition 0.000 claims description 2
- 240000000171 Crataegus monogyna Species 0.000 claims description 2
- 235000002313 Crataegus paludosa Nutrition 0.000 claims description 2
- 235000009840 Crataegus x incaedua Nutrition 0.000 claims description 2
- 239000006071 cream Substances 0.000 description 14
- 239000000203 mixture Substances 0.000 description 12
- 230000000694 effects Effects 0.000 description 9
- 239000000839 emulsion Substances 0.000 description 9
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 7
- 102000003425 Tyrosinase Human genes 0.000 description 7
- 108060008724 Tyrosinase Proteins 0.000 description 7
- 239000000284 extract Substances 0.000 description 7
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- 238000009472 formulation Methods 0.000 description 5
- 239000006210 lotion Substances 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 239000008363 phosphate buffer Substances 0.000 description 5
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 4
- 230000005764 inhibitory process Effects 0.000 description 4
- 239000012488 sample solution Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 229940058015 1,3-butylene glycol Drugs 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 206010014970 Ephelides Diseases 0.000 description 3
- 108010024636 Glutathione Proteins 0.000 description 3
- 208000003351 Melanosis Diseases 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 3
- 238000002835 absorbance Methods 0.000 description 3
- 229960005070 ascorbic acid Drugs 0.000 description 3
- 235000010323 ascorbic acid Nutrition 0.000 description 3
- 239000011668 ascorbic acid Substances 0.000 description 3
- 235000019437 butane-1,3-diol Nutrition 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 229960003180 glutathione Drugs 0.000 description 3
- 239000003960 organic solvent Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 235000021355 Stearic acid Nutrition 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000003974 emollient agent Substances 0.000 description 2
- 235000019441 ethanol Nutrition 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 229940075507 glyceryl monostearate Drugs 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 229940057995 liquid paraffin Drugs 0.000 description 2
- 230000003020 moisturizing effect Effects 0.000 description 2
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 239000008117 stearic acid Substances 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- LOIYMIARKYCTBW-OWOJBTEDSA-N trans-urocanic acid Chemical compound OC(=O)\C=C\C1=CNC=N1 LOIYMIARKYCTBW-OWOJBTEDSA-N 0.000 description 2
- CUNWUEBNSZSNRX-RKGWDQTMSA-N (2r,3r,4r,5s)-hexane-1,2,3,4,5,6-hexol;(z)-octadec-9-enoic acid Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O CUNWUEBNSZSNRX-RKGWDQTMSA-N 0.000 description 1
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
- 240000008067 Cucumis sativus Species 0.000 description 1
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- 239000011626 DL-alpha-tocopherylacetate Substances 0.000 description 1
- 235000001809 DL-alpha-tocopherylacetate Nutrition 0.000 description 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 1
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 description 1
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 description 1
- 150000000996 L-ascorbic acids Chemical class 0.000 description 1
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 1
- 235000011613 Pinus brutia Nutrition 0.000 description 1
- 241000018646 Pinus brutia Species 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- KQZNFGJQTPAURD-NBWQQBAWSA-N ascorbyl dipalmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](OC(=O)CCCCCCCCCCCCCCC)[C@H]1OC(=O)C(O)=C1O KQZNFGJQTPAURD-NBWQQBAWSA-N 0.000 description 1
- 235000021302 avocado oil Nutrition 0.000 description 1
- 239000008163 avocado oil Substances 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- 239000007854 depigmenting agent Substances 0.000 description 1
- VJNCICVKUHKIIV-UHFFFAOYSA-N dopachrome Chemical compound O=C1C(=O)C=C2NC(C(=O)O)CC2=C1 VJNCICVKUHKIIV-UHFFFAOYSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- CRPCXAMJWCDHFM-UHFFFAOYSA-M sodium;5-oxopyrrolidine-2-carboxylate Chemical compound [Na+].[O-]C(=O)C1CCC(=O)N1 CRPCXAMJWCDHFM-UHFFFAOYSA-M 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 229960005078 sorbitan sesquioleate Drugs 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- LOIYMIARKYCTBW-UHFFFAOYSA-N trans-urocanic acid Natural products OC(=O)C=CC1=CNC=N1 LOIYMIARKYCTBW-UHFFFAOYSA-N 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Botany (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Description
本発明は美白化粧料、さらに詳しくは、植物の
抽出エキスを配合してなる安全性の高い新規な美
白化粧料に関するものである。
従来から美白化粧料には、主としてアスコルビ
ン酸・グルタチオン・コロイドイオウ等が配合さ
れてきており、このような美白化粧料は皮膚の色
黒・シミ・ソバカスの防止などの美容効果のうえ
で、非常に関心の深いものである。しかしなが
ら、アスコルビン酸は酸化を受けやすく一定の効
果の発現が期待されにくく、またグルタチオンや
コロイドイオウは特有の異臭及び沈殿等が生じる
という様な欠点を有している。
一方、最近では、効果及び安全性等の点から、
再び天然物が注目されるようになつてきた（特開
昭50−135236号、特開昭52−79033号、特開昭53
−15432号、特開昭53−8333号、特開昭54−2344
号、特開昭57−163307号）。すなわち、植物の抽
出エキス等には種々の効果を有するものがあり、
作用が緩和で、連用によつて十分にその効果が発
揮され、また安全性も高いために化粧料の配合剤
としては好ましいと考えられる。
係る事情に鑑み、本発明者らは広く天然に存在
する植物の抽出エキスについて、美白剤としての
有用性を鋭意研究の結果、特定の植物の抽出エキ
スは高いチロシナーゼ活性阻害率を有し、これら
を配合した化粧料は、安全性が高く、美白効果が
期待でき、安定性も高いことを見い出し本発明を
完成させた。
すなわち、本発明は、アルテア、イブキトラノ
オ、セイヨウサンザシ、ハクセンピ及びヤグルマ
ギクから選ばれる１種または２種以上の組み合わ
せからなる植物の抽出エキスを配合したことを特
徴とする安全性・安定性に優れた美白化粧料を提
供するものである。
本発明に於ける植物の抽出エキスの美白効果
を、チロシナーゼ活性阻害率を測定することによ
り試験した。試験方法は次のとおりである。植物
の抽出エキス：乾燥した植物細切20部を１，３−
ブチレングリコール100部にて３日間抽出する。
試料溶液：１，３−ブチレングリコール抽出によ
る植物の抽出エキスについては、２倍量の１／
10Mリン酸緩衝液（pH6.8）を加えて試料溶液と
した。またエチルアルコール抽出による植物の抽
出エキスについては、その50mlを濃縮・乾固し、
150mlの１／10Mリン酸緩衝液（pH6.8）に分
散・溶解したものを試料溶液とした。
酵素溶液：チロシナーゼ（26，000単位：シグマ
社）10mgを１／10Mリン酸緩衝液（pH6.8）20ml
に溶解する。
基質溶液：Ｌ−DOPA（東京化成）198.0mgを１／
10Mリン酸緩衝液（pH6.8）100mlに溶解する。
測定方法：試料溶液3.0mlに酵素溶液0.1ml及び
１／10Mリン酸緩衝液（pH6.8）0.9mlを加えトー
タル4.0mlとし、30℃にて10分間インキユベート
する。ここで、あらかじめ30℃でインキユベート
しておいた基質溶液1.0mlをこの反応溶液に加え、
10分間反応させる。ついで475nmに於ける吸光度
（ODS）を測定する。さらに、加熱失活させた酵
素を用いて同様に反応させた吸光度（ODHE）及
び試料無添加のときの吸光度（ODB）を測定し、
次式よりチロシナーゼ活性の阻害率を算出する。
チロシナーゼ阻害率（％）
＝ODB−ODS／ODB−ODHF×100
結果を第１表に示す。
The present invention relates to a whitening cosmetic composition, and more particularly to a novel highly safe whitening cosmetic composition containing a plant extract. Traditionally, whitening cosmetics have mainly contained ascorbic acid, glutathione, colloidal sulfur, etc., and these whitening cosmetics have extremely effective beauty effects such as preventing dark skin, age spots, and freckles. is of deep interest. However, ascorbic acid is susceptible to oxidation, making it difficult to expect it to produce a certain effect, and glutathione and colloidal sulfur have drawbacks such as a characteristic off-odor and precipitation. On the other hand, recently, from the point of view of effectiveness and safety,
Natural products are once again attracting attention (Japanese Patent Application Laid-open Nos. 135236-1983, 79033-1973, 1973)
−15432, JP-A-53-8333, JP-A-54-2344
No., Japanese Patent Publication No. 57-163307). In other words, some plant extracts have various effects.
It is considered to be preferable as a compounding agent in cosmetics because its action is mild, its effects are fully demonstrated with continuous use, and it is also highly safe. In view of these circumstances, the present inventors conducted extensive research into the usefulness of extracts from a wide range of naturally occurring plants as skin whitening agents, and found that certain plant extracts have a high tyrosinase activity inhibition rate. We have completed the present invention by discovering that cosmetics containing the following are highly safe, can be expected to have a whitening effect, and have high stability. That is, the present invention provides a highly safe and stable product which is characterized by containing a plant extract consisting of one or a combination of two or more selected from Althea, Ibuchiranium, Hawthorn, Cucumber and Cornflower. It provides whitening cosmetics. The whitening effect of the plant extract in the present invention was tested by measuring the inhibition rate of tyrosinase activity. The test method is as follows. Plant extract: 1,3-20 parts of dried shredded plants
Extract with 100 parts of butylene glycol for 3 days. Sample solution: For plant extracts extracted with 1,3-butylene glycol, double the amount by 1/2.
A 10M phosphate buffer (pH 6.8) was added to prepare a sample solution. In addition, for the plant extract obtained by ethyl alcohol extraction, 50ml of it is concentrated and dried.
A sample solution was prepared by dispersing and dissolving the sample in 150 ml of 1/10M phosphate buffer (pH 6.8). Enzyme solution: 10 mg of tyrosinase (26,000 units: Sigma) in 20 ml of 1/10M phosphate buffer (pH 6.8)
dissolve in Substrate solution: 198.0 mg of L-DOPA (Tokyo Kasei)
Dissolve in 100ml of 10M phosphate buffer (pH 6.8). Measurement method: Add 0.1 ml of enzyme solution and 0.9 ml of 1/10M phosphate buffer (pH 6.8) to 3.0 ml of sample solution to make a total of 4.0 ml, and incubate at 30°C for 10 minutes. Here, 1.0 ml of the substrate solution previously incubated at 30°C was added to this reaction solution.
Incubate for 10 minutes. The absorbance at 475 nm (OD S ) is then measured. Furthermore, the absorbance (OD HE ) of a similar reaction using heat-inactivated enzyme and the absorbance (OD B ) when no sample was added were measured.
The inhibition rate of tyrosinase activity is calculated from the following formula. Tyrosinase inhibition rate (%) = OD B − OD S / OD B − OD HF ×100 The results are shown in Table 1.
【表】
第１表の結果より明らかなように、本発明で適
用される５種の植物の抽出エキスは、チロシナー
ゼを抑制し、ドーパクロームの生成を低下させ、
美白効果を有することが実証された。
本発明に於ける植物の抽出エキスの調製は、一
般的には、乾燥及び生植物を細切りにしたもの10
−30部に、エタノール・プロピレングリコール・
１，３−ブチレングリコール等の有機溶媒、及び
これら有機溶媒の組み合わせ、もしくは水とこれ
ら有機溶媒との混合物などの溶媒100部を加え、
室温にて所定日数、時々攪拌しながら抽出を行な
い、その後ろ別して抽出液を得る。
本発明の美白化粧料に於ける植物の抽出エキス
の配合量は、0.001−20重量％が適当であり、特
に0.1−10重量％が好ましい。なお、本発明に於
ける植物の抽出エキスを５重量％配合した美白化
粧水は、すべて有効なチロシナーゼ抑制効果を示
すものであり、安全性も高く、化粧料として系の
安定性も高いものであつた。
なお、本発明の美白化粧料には、公知の皮膚美
白効果を有する薬剤、例えば、アスコルビン酸・
アスコルビン酸誘導体・システイン・グルタチオ
ン・イオウ・ウロカニン酸・ウロカニン酸誘導体
及びその他の紫外線吸収剤等を組み合わせて配合
することが可能であり、安全で安定な、高い美白
効果を発現するものである。
また、本発明に於ける美白化粧料は、柔軟性化
粧水・収斂性化粧水・洗浄用化粧水等の化粧水
類、エモリエントクリーム・モイスチユアクリー
ム・マツサージクリーム・クレンジングクリー
ム・メイキヤツプクリーム等のクリーム類、エモ
リエント乳液・モイスチユア乳液・ナリシング乳
液・クレンジング乳液等の乳液類、ゼリー状パツ
ク・ペースト状パツク・粉末状パツク等のパツク
類、及び洗顔料類の形態とすることができるもの
である。
次に本発明について実施例を挙げてさらに説明
する。これらは本発明を何ら限定するものではな
い。
［実施例１］ 美白クリーム
（処方） （重量％）
(1) ステアリン酸 1.0
(2) ステアリルアルコール 4.0
(3) モノステアリン酸グリセリン 3.0
(4) 硬化油 7.0
(5) 流動パラフイン 10.0
(6) サフラワー油 2.0
(7) セスキオレイン酸ソルビタン 1.0
(8) 香料 0.5
(9) イブキトラノオエキス 5.0
(10) 水酸化ナトリウム 0.05
(11) カルボキシビニルポリマー 0.1
(12) 防腐剤 0.1
(13) 精製水 残量
（製法）
Ａ (1)〜(8)を加熱溶解（70℃）する。
Ｂ (10)〜(13)を加熱溶解（70℃）する。
Ｃ ＡにＢを加え乳化をし、それに(9)を加えて混
合する。
Ｄ 冷却をして美白クリームを得る。
〔実施例２〕 美白乳液
（処方） （重量％）
(1) ステアリン酸 0.5
(2) セタノール 1.5
(3) モノステアリン酸グリセリン 2.0
(4) 流動パラフイン 5.0
(5) アボガドオイル 1.0
(6) セスキオレイン酸ソルビタン 0.5
(7) 酢酸dl−α−トコフエロール 0.1
(8) ジパルミチン酸アスコルビル 0.5
(9) 香料 0.2
(10) アルテアエキス 1.0
(11) クジンエキス 1.0
(12) １，３−ブチレングリコール 5.0
(13) 水酸化ナトリウム 0.02
(14) dl−ピロリドンカルボン酸ナトリウム 0.1
(15) 防腐剤 0.1
(16) 精製水 残量
（製法）
Ａ (1)〜(9)を加熱溶解（70℃）する。
Ｂ (12)〜(16)を加熱溶解（70℃）する。
Ｃ ＡにＢを加えて乳化をし、それに(10)，(11)を加
えて混合する。
Ｄ 冷却をして美白乳液を得る。
〔比較例１〕 クリーム
（処方）
実施例１美白クリームの処方で(9)イブキトラノ
オエキスを除外したものを比較例１クリームの処
方とする。
（製法）
実施例１の製法に準ずる。
本発明の美白化粧料の使用効果につき、使用テ
ストにより試験を行なつた。使用テストは、それ
ぞれ30〜40才の10名の女性をパネルとし、毎日朝
と夜の２回、洗顔後、試験化粧料を適量顔面に２
週間にわたつて塗布することにより行なつた。試
験化粧料は、実施例１の美白クリーム、実施例２
の美白乳液、比較例１のクリームの３種の化粧料
とした。評価は、シミ・ソバカスに対する効果を
判定した。結果は第２表に示すとおりである。[Table] As is clear from the results in Table 1, the five plant extracts applied in the present invention suppress tyrosinase, reduce dopachrome production,
It has been demonstrated that it has a whitening effect. In the preparation of plant extracts in the present invention, dried and fresh plants are generally cut into thin pieces.
−30 parts of ethanol, propylene glycol,
Add 100 parts of a solvent such as an organic solvent such as 1,3-butylene glycol, a combination of these organic solvents, or a mixture of water and these organic solvents,
Extraction is carried out at room temperature for a predetermined number of days with occasional stirring, and then separated to obtain an extract. The amount of the plant extract in the whitening cosmetic composition of the present invention is suitably 0.001-20% by weight, particularly preferably 0.1-10% by weight. In addition, all of the whitening lotions containing 5% by weight of plant extracts according to the present invention exhibit an effective tyrosinase inhibiting effect, are highly safe, and have a highly stable system as a cosmetic. It was hot. In addition, the whitening cosmetic of the present invention contains drugs that have a known skin whitening effect, such as ascorbic acid.
It is possible to combine combinations of ascorbic acid derivatives, cysteine, glutathione, sulfur, urocanic acid, urocanic acid derivatives, and other ultraviolet absorbers, and it exhibits a safe, stable, and high whitening effect. In addition, the whitening cosmetics according to the present invention include lotions such as soft lotion, astringent lotion, and cleaning lotion, emollient cream, moisturizing cream, pine surge cream, cleansing cream, makeup cream, etc. Creams, emulsions such as emollient emulsions, moisturizing emulsions, nourishing emulsions, cleansing emulsions, etc., packs such as jelly packs, paste packs, powder packs, etc., and facial cleansers. . Next, the present invention will be further explained with reference to Examples. These do not limit the present invention in any way. [Example 1] Whitening cream (formulation) (wt%) (1) Stearic acid 1.0 (2) Stearyl alcohol 4.0 (3) Glyceryl monostearate 3.0 (4) Hydrogenated oil 7.0 (5) Liquid paraffin 10.0 (6) Flower oil 2.0 (7) Sorbitan sesquioleate 1.0 (8) Fragrance 0.5 (9) Ibuchiranium extract 5.0 (10) Sodium hydroxide 0.05 (11) Carboxyvinyl polymer 0.1 (12) Preservative 0.1 (13) Purified water Remaining amount (Manufacturing method) A (1) to (8) are heated and dissolved (70°C). B (10) to (13) are dissolved by heating (70°C). C Add B to A to emulsify, then add (9) to it and mix. D. Cool to obtain whitening cream. [Example 2] Whitening emulsion (formulation) (wt%) (1) Stearic acid 0.5 (2) Cetanol 1.5 (3) Glyceryl monostearate 2.0 (4) Liquid paraffin 5.0 (5) Avocado oil 1.0 (6) Sesquiolein Sorbitan acid 0.5 (7) dl-α-tocopherol acetate 0.1 (8) Ascorbyl dipalmitate 0.5 (9) Fragrance 0.2 (10) Althea extract 1.0 (11) Kujin extract 1.0 (12) 1,3-butylene glycol 5.0 (13) Sodium hydroxide 0.02 (14) Sodium dl-pyrrolidonecarboxylate 0.1 (15) Preservative 0.1 (16) Purified water Remaining amount (manufacturing method) A Heat and dissolve (1) to (9) (70°C). B Melt (12) to (16) by heating (70°C). C Add B to A to emulsify, then add (10) and (11) to it and mix. D. Cool to obtain a whitening emulsion. [Comparative Example 1] Cream (Formulation) The formulation of Comparative Example 1 cream was the same as the formulation of the whitening cream of Example 1, except that (9) Ibuchiranium extract was excluded. (Manufacturing method) According to the manufacturing method of Example 1. The effect of using the whitening cosmetic composition of the present invention was tested by use test. In the usage test, a panel of 10 women aged 30 to 40 each applied an appropriate amount of the test cosmetics to their faces twice a day, once in the morning and once in the evening, after washing their faces.
This was done by applying it over a period of weeks. The test cosmetics were the whitening cream of Example 1 and Example 2.
Three types of cosmetics were prepared: the whitening emulsion of 2008, and the cream of Comparative Example 1. The evaluation was based on the effect on age spots and freckles. The results are shown in Table 2.
【表】
第２表の結果より明らかなように、実施例１の
美白クリーム及び実施例２の美白乳液の使用によ
り、シミ・ソバカスが目立たなくなつたという効
果が、高い有効率をもつて確認された。[Table] As is clear from the results in Table 2, the use of the whitening cream of Example 1 and the whitening emulsion of Example 2 was confirmed to have a high effectiveness rate in making spots and freckles less noticeable. It was done.
Claims (1)
シ、ハクセンピ及びヤグルマギクから選ばれる１
種または２種以上の組み合わせからなる植物の抽
出エキスを配合したことを特徴とする美白化粧
料。1 Selected from Althea, Ibuchirania, Hawthorn, Hakusenpi and Cornflower
A whitening cosmetic containing a plant extract consisting of seeds or a combination of two or more kinds.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58209545A JPS60104005A (en) | 1983-11-08 | 1983-11-08 | Skin beutifying cosmetic |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58209545A JPS60104005A (en) | 1983-11-08 | 1983-11-08 | Skin beutifying cosmetic |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS60104005A JPS60104005A (en) | 1985-06-08 |
| JPH0587482B2 true JPH0587482B2 (en) | 1993-12-16 |
Family
ID=16574579
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58209545A Granted JPS60104005A (en) | 1983-11-08 | 1983-11-08 | Skin beutifying cosmetic |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS60104005A (en) |
Cited By (1)
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|---|---|---|---|---|
| JP2016041668A (en) * | 2014-08-19 | 2016-03-31 | 株式会社山田養蜂場本社 | Skin whitening composition |
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|---|---|---|---|---|
| JP2542849B2 (en) * | 1987-06-04 | 1996-10-09 | 株式会社コーセー | Topical skin |
| JP3292499B2 (en) * | 1992-03-19 | 2002-06-17 | 株式会社資生堂 | Skin external preparation for slimming |
| JP3696271B2 (en) * | 1994-09-22 | 2005-09-14 | 花王株式会社 | Whitening cosmetics |
| JPH0892055A (en) * | 1994-09-22 | 1996-04-09 | Kao Corp | Whitening cosmetic |
| IT1295974B1 (en) * | 1996-11-04 | 1999-05-28 | Claudio Risicato | DISINFECTANT COMPOSITION IN PARTICULAR FOR THE PREVENTION OF DERMATITIS FROM NAP |
| JP3119622B2 (en) * | 1998-06-16 | 2000-12-25 | 有限会社松川化学 | Cosmetics |
| JP2000119156A (en) * | 1998-10-14 | 2000-04-25 | Kose Corp | Skin lotion |
| US6214352B1 (en) | 2000-01-06 | 2001-04-10 | Matsukawa Kagaku Co., Ltd. | Tyrosinase inhibiting agent |
| JP4565689B2 (en) * | 2000-02-09 | 2010-10-20 | ポーラ化成工業株式会社 | External composition for skin to suppress α-MSH |
| FR2814070B1 (en) * | 2000-09-20 | 2002-12-13 | Silab Sa | METHOD FOR EXTRACTING AN ACTIVE INGREDIENT BASED ON MALVA SYLVESTRIS, ACTIVE INGREDIENT OBTAINED AND COSMETIC TREATMENT USING THE SAME |
| KR20020047760A (en) * | 2000-12-14 | 2002-06-22 | 김광석 | Cosmetics comprising dictamnus root extracts for skin whitening |
| KR20020047761A (en) * | 2000-12-14 | 2002-06-22 | 김광석 | Cosmetics comprising dictamnus root extracts for antioxidation |
| JP3851829B2 (en) * | 2002-02-28 | 2006-11-29 | 株式会社ノエビア | Skin preparation for the purpose of increasing scattered light on the skin surface |
| JP2003306418A (en) * | 2003-05-26 | 2003-10-28 | Pola Chem Ind Inc | Sunscreening cosmetic |
| JP4574959B2 (en) * | 2003-06-02 | 2010-11-04 | ポーラ化成工業株式会社 | External skin preparation for suppressing α-MSH |
| KR101161568B1 (en) | 2003-12-15 | 2012-07-04 | 포라 가세이 고교 가부시키가이샤 | External preparations for skin |
| JP4499543B2 (en) * | 2003-12-15 | 2010-07-07 | 株式会社クラレ | Topical skin preparation |
| EP1768684B1 (en) * | 2004-06-09 | 2012-05-23 | Laboratoire Nuxe | Composition comprising a blue lotus extract for the treatment of facial uncontrolled muscular contractions |
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| JP2009067804A (en) * | 2008-10-30 | 2009-04-02 | Pola Chem Ind Inc | SKIN EXTERNAL PREPARATION FOR WHITENING RELATING TO alpha-MSH |
| DE102009019104A1 (en) * | 2009-04-29 | 2010-11-04 | Bionorica Se | Cosmetic or dermatological composition containing hydrolysates from plant extracts |
| JP5789235B2 (en) * | 2012-09-14 | 2015-10-07 | 木下製薬株式会社 | Whitening skin external preparation and method for producing the same |
| JP5986890B2 (en) * | 2012-11-06 | 2016-09-06 | 株式会社ファンケル | MIF secretion inhibitor |
| CN103127268B (en) * | 2013-03-14 | 2014-07-30 | 郭宏刚 | Oral beauty powder |
| FR3003758B1 (en) * | 2013-03-27 | 2015-07-17 | Basf Beauty Care Solutions France Sas | COSMETIC OR DERMATOLOGICAL USE OF A POLYGONUM BISTORTA EXTRACT |
| JP6378968B2 (en) * | 2014-08-19 | 2018-08-22 | 株式会社山田養蜂場本社 | Whitening composition |
| JP6392026B2 (en) * | 2014-08-19 | 2018-09-19 | 株式会社山田養蜂場本社 | Whitening composition |
| JP2020164486A (en) * | 2019-03-29 | 2020-10-08 | 丸善製薬株式会社 | Anti-aging agents, antioxidants, anti-inflammatory agents, and whitening agents, as well as cosmetics |
| CN117916384A (en) | 2021-10-01 | 2024-04-19 | 株式会社益力多本社 | Fermented product of herb sunflower and application thereof |
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|---|---|---|---|---|
| JPS5221339A (en) * | 1975-08-07 | 1977-02-17 | Tokutaro Matsui | Cosmetic for the skin |
| JPS5388333A (en) * | 1977-01-13 | 1978-08-03 | Sunstar Inc | Cosmetics |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016041668A (en) * | 2014-08-19 | 2016-03-31 | 株式会社山田養蜂場本社 | Skin whitening composition |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS60104005A (en) | 1985-06-08 |
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