JPS6360910A - Skin drug for external use - Google Patents

Abstract

PURPOSE:To obtain a skin drug for external use, by blending Cuscuta seed or an extract thereof with pyridoxine, biotin or/and nicotinic acid, etc., particularly effective acting on preventing, curing and treating pimples and capable of effectively preventing dandruff by using for the scalp. CONSTITUTION:A skin drug for external use, obtained by blending (A) powdered Cuscuta seed which is a crude drug or an extract thereof with (B) one or more selected from pyridoxine, biotin, nicotinic acid, lipoic acid, riboflavin, retinol, retinoic acid, beta-carotene, cholecarciferol and derivatives thereof, capable of excellently permeating into the skin and particularly effective in preventing, curing and treating pimples caused by hypersecretion of sebum and preventing dandruff without giving irritation or hormonal side effect. The amounts of the ingredients are as follows. Normally >=0.005wt%, preferably up to 10wt% ingredient (A) expressed in terms of drying residue and 0.001-50wt%, preferably 0.01-20wt% ingredient (B).

Description

[Detailed description of the invention] [Industrial application field] The present invention relates to an external skin preparation containing crude drug extracts.

More specifically, the present invention combines the crude drug Toshishi or its extract with pyridoxine, biotin, nicotinic acid,
A skin external preparation characterized by containing one or more selected from the group consisting of riboic acid, cholecalciphenol, riboflavin, retinol, retinoic acid, β-carotene, cholecalciphenol, and derivatives thereof. It is particularly effective in preventing, treating, and treating acne caused by excessive secretion of sebum, and can be used on the scalp to effectively prevent dandruff.

[Prior art] Acne is a skin disease that mainly occurs during adolescence and is called acne vulgaris, which is clinically defined as a chronic inflammatory change that occurs in the name tag, mainly in the sebaceous gland system. There is.

The etiology of acne is still unclear, and although it is a skin disease in which various factors are intricately intertwined, in general,
Excessive sebum secretion, epikeratosis, and epidermal bacteria are thought to play important roles.

Therefore, as external preparations for treating acne, creams and ointments containing sebum secretion inhibitors and antibacterial agents are commonly used depending on the various factors, and various vitamin preparations are also used depending on the symptoms. However, when vitamins were administered transdermally, satisfactory therapeutic effects were not obtained.

[Problems to be Solved by the Invention] The present inventors were researching compounds that would increase the effects of conventional so-called vitamins on the skin, and discovered that toshishi or its extract, pyridoxine, biotin, It has been discovered that a skin external preparation characterized by containing nicotinic acid, lipoic acid, cholecalciferol, riboflavin, retinol, retinoic acid, β-carotene, cholecalciferol, etc. or derivatives thereof can achieve this purpose. Thus, the present invention was completed.

[Means for Solving the Problems] That is, the present invention combines toshishi or its extract with pyridoxine, biotin, nicotinic acid, lipoic acid, cholecalciferol, riboflavin, retinol, retinoic acid,
This external skin preparation is characterized by containing one or more selected from the group consisting of β-carotene, cholecalciferol, and derivatives thereof. Such external skin preparations are particularly effective in preventing, treating, and treating acne.
It can also be used on the scalp to effectively prevent dandruff.

The configuration of the present invention will be explained in detail below.

In the present invention, toshishi and its extract are used.

The toshishi used in the present invention is mainly the seeds of Kassula japonica, used alone as a tonic or tonic, or as a Chinese herbal preparation.
It is used as a component of crude drug preparations, and most of them are taken internally, and there are only a few examples of its use in external preparations.

In the present invention, 0.005% of the extract (residue after distilling off the extraction solvent) obtained by extraction using toshishi powder or water or aqueous alcohol, such as ethanol, or a mixture thereof, usually at 15 to 25°C, is used. (weight%)
Mix the above. The upper limit of the blending amount is not particularly limited, but from the viewpoint of commercial value such as coloring, it is preferable to blend the dry residue up to about 10% in total. The present invention includes any one selected from the group consisting of pyridoxine, biotin, nicotinic acid, lipoic acid, cholecalciferol, riboflavin, retinol, retinoic acid, β-carotene, cholecalciferol, and derivatives thereof. 2
Seeds or more are used in addition to the above toshishi or its extract.

The blending amount is 0.001% or more and 50% or less, preferably 0.01% or more and 20% or less.

The skin external preparation of the present invention contains toshishi or its extract, pyridoxine, biotin, nicotinic acid, etc. and its derivatives, as well as zinc and its compounds, lactic acid, etc., exfoliating agents, antibacterial agents, and may vary depending on the properties. However, oils, surfactants, water, ethanol, humectants, thickeners, fragrances, pigments, and the like can be appropriately added within the range that does not impair the effects of the present invention.

The external preparation for skin of the present invention may be in any form as long as it can be applied to the skin, such as a cream, ointment, or lotion.

[Effects of the Invention] The skin external preparation of the present invention penetrates the skin very well, causes no irritation or hormonal side effects, is particularly effective in preventing, treating, and treating acne, and can be used on the scalp. Dandruff can be effectively prevented.

[Example] Next, a detailed description will be given with reference to examples.

Example 1 Lotion Sorbitol (70%) 3.0g Glycerin 5.0g Pyridoxine Hydrochloride 0.02g Water
Mix and dissolve 70.0g of these ingredients, add allantoin 0.1g Toshishi extract 1.0g polyoxyethylene hydrogenated castor oil derivative 0.5g ethanol 20.0g fragrance
Add an appropriate amount of the mixed solution while stirring to obtain a lotion as a homogeneous solution.

Example 2 Cream beeswax 10.0g paraffin wax 6.0g lanolin
3.0g isopropyl myristate 6.0g squalane
8.0g liquid paraffin 25.0
g Toshishi extract 0.05g biotin 2.0g riboic acid
0.5g polyoxyethylene solpicone monostearate)
1. 8g sorbitan monostearate 4.2
g Preservative Mix appropriate amounts of these ingredients, heat at about 75°C to dissolve, and add to this heated at about 75°C Propylene glycol 2.0g Borax
0.7g water
Add 26.0g of the mixture while stirring, cool, add an appropriate amount of fragrance at 55°C,
Continue stirring until 5°C and leave to obtain cream.

The effects of the present invention will be explained in more detail by briefly giving clinical examples.

(Medicine used) A lotion-type skin external preparation obtained by the following formulation and manufacturing method was used.

Toshishi extract 5.0gP,
O, E, (60 mol) hydrogenated castor oil 2.0 g
Glycerin 10.0g Dipropylene glycol 10. Ogl, 3-butylene glycol 5.0g polyethylene glycol 15
00 Heat and melt 5.0g or more at 60°C. Add to this pyridoxine hydrochloride 1.0g cetyl isooctanate 10.0g squalane
5.0g methylparaben
Add and mix 1.3 g of the solution heated to <60'C, and process with a homomixer to form a gel.

Next, 0.3 g of carboxyvinyl polymer and 0.03 g of sodium xametaphosphate dissolved in 11.0 g of ion-exchanged water were slowly added to this gel and dispersed with a homomixer, followed by 0.12 g of potassium hydroxide. A solution dissolved in 40.0 g of ion-exchanged water was added and mixed, and the mixture was emulsified using a homomixer to obtain a lotion-type skin preparation for external use.

In addition, as a control drug, an external preparation containing only Toshishiki extract or pyridoxine hydrochloride was used.

Case No. 1 to 10 Case N containing only pyridoxine hydrochloride
o, 11-20 Case No. containing only Toshishi extract
21-30 A total of 30 men and women using pyridoxine hydrochloride + toshishiki extract for about 1 month.

(How to use) After thoroughly washing your face with cosmetic soap, apply the above-mentioned lotion-type skin preparation once a day only on the branch area.
It was applied ~3 times.

(Observation items and observation points) Observe the following three symptoms: vomiting, papules, and IIF, and then combine the severity of each individual finding to determine the severity of acne vulgaris: severe, moderate, and mild. Divided into stages. Follow-up observation was performed before treatment, 1 week after treatment, 2 weeks after treatment, 3 weeks after treatment, and 4 weeks after treatment.

(Overall improvement level) The degree of improvement in symptoms due to the drug used compared to before use, markedly improved (H+), considerably improved (slightly), somewhat improved (+), unchanged (±), worsened (-). divided.

(Usefulness) Based on the degree of overall improvement, it was ranked as extremely useful (H+) and quite useful (
4+), somewhat useful (+), and ineffective (±).

(Results) The clinical test results for a total of 30 people (10 men and 20 women) showed that of the 10 people who used topical preparations containing only pyridoxine hydrochloride, 4 (40%) said + (slightly useful) and 6 (40%) said ± (ineffective). 60%
) Out of 10 people using topical preparations containing only toshishiki extract, 3 (30%) said + (slightly useful), 7 (70%) said ± (ineffective) Out of 10 using topical preparations containing pyridoxine hydrochloride + toshishiki extract , 2 people (20X) said + (somewhat useful), 4 people (40X) said ``very useful'', 4 people said (very useful) (
40X), demonstrating the effectiveness of the present invention in treating acne.

Claims (1)

[Claims] Toshishi or its extract, pyridoxine, biotin,
It is characterized by containing one or more selected from the group consisting of nicotinic acid, ribic acid, cholecalciphenol, riboflavin, retinol, retinoic acid, β-carotene, cholecalciphenol, and derivatives thereof. External skin preparation.