JPS6127914A - Cosmetic - Google Patents

Abstract

PURPOSE:To provide a cosmetic free from undesirable side effect such as hormonic effect, and having excellent hair-tonic effect and acne-remedying effect, by compounding a specific ubiquinone with oxendlone. CONSTITUTION:The objective hair-tonic cosmetic can be prepared by compounding one or more compounds of formula (n is integer of 7-10) with oxendlone (16beta-ethyl-17beta-hydroxy-4-estren-3-one). The compound of formula is ubiquinone 7, ubiquinone 8, ubiquinone 9 or ubiquinone 10, and its amount is 0.01-2wt%. The amount of oxendlone is 0.0001-1wt%. The cosmetic is free from side effects such as hormonic effect, has high safety, and has really excellent hair- tonic effect and acne-remedying effect.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a cosmetic that does not cause undesirable side effects such as hormonal effects, and has excellent hair growth and acne treatment effects.

Physiological symptoms such as baldness, hair loss, seborrhea, and acne are said to be due to increased stimulation of male hormone 7 based on excessive accumulation of male hormones, but recently, hair roots and sebum! i
The main body of this androgen activity in these target organs is that testosterone is
It has become well known that 5a-dihydrotestosterone (hereinafter abbreviated as 5a-DHT) is reduced by an enzyme named 5α-reductase (hereinafter abbreviated as reductase). In other words, testosterone (male hormone) produced by the male glands and adrenal glands travels through the bloodstream to the sebaceous glands, where it is converted into 5α-DHT, a more powerful male hormone, by reductase within the sebaceous gland cells. This 5α-DHT binds to intracellular receptors and acts on the nucleus to promote the proliferation of sebaceous gland cells, while acting on hair matrix cells to suppress their cell division and hinder hair growth.

Therefore, signs of baldness, hair loss, seborrhea, acne, etc.
inhibiting the activity of reductase and 5α-D
It is believed that HT can be reduced or prevented by inhibiting the binding between HT and its receptor protein, and as a result of intensive research based on this viewpoint, the present inventors have discovered that oxendrone has an excellent effect. A patent application was filed.

However, the mechanisms of hair loss, hair growth, seborrhea, acne, etc. are extremely complex, and simply blocking male hormones is still insufficient, and further improvements have been desired.

In view of the above circumstances, the present inventors have conducted intensive research to obtain cosmetics that are safe and have truly excellent hair-nurturing and acne-treating effects without having undesirable side effects such as hormonal effects. As a result, the inventors have discovered that the above object can be achieved by combining oxendron and a specific substance, and have completed the present invention based on this knowledge.

That is, the present invention is a cosmetic product characterized by blending one or more compounds represented by the following general formula with oxendrone.

The configuration of the present invention will be explained in detail below.

The compound represented by the following general formula (where n is an integer of 7 to 10) used in the present invention is coenzyme Q, which was first discovered by R.A. Morton in 1955, and is It is named ubiquinone because it is found in a wide range of living organisms such as molds, yeasts, plants, and animals, and the only difference between them is the number of isopremade side chains (n).

In the present invention, one or two or more of these with n of 7 to 10, ubiquinone 7, ubiquinone 8, ubiquinone 9, and ubiquinone 10, are used, and the amount thereof is determined in the cosmetic of the present invention. It is about 0.01 to 2% by weight.

Oxendrone used in the present invention has a chemical name of 16β.
-ethyl-17β-hydroxy-4-nystrene-3-
It is a white to pale yellow, odorless powder. The cosmetic composition of the present invention contains about 0.0001 to 1% by weight.

In addition to the above-mentioned essential ingredients, the cosmetic according to the present invention contains additives commonly used in cosmetics, such as hinokitiol, hexachlorophene, phenol, benzalkonium chloride, cetylpyridinium chloride, undecylenic acid, trichlorocarbanilide, and antibacterial agents such as bithionol, derivatives such as glycyrrhizic acid and its ammonium salts, anti-inflammatory refreshing agents such as allantoin and menthol,
Salicylic acid, zinc and its compounds, drugs such as lactic acid and its alkyl esters, animal and vegetable oils such as olive oil, macadamia nut oil, and squalane, hydrocarbon oils such as liquid paraffin, inpropyl myristate, cetyl isooctanoate, 2 - Ester oils such as ethylhexyl balmidate, waxes such as beeswax and carnauba wax, oils such as higher fatty acids and higher alcohols, water, derivatives such as lactic acid and its ethyl ester, polyhydric acids such as polyethylene glycol, glycerin, and sorbitol. Alcohol, lower alcohols such as ethanol, humectants such as mucopolysaccharides, pyrrolidone carboxylates, thickeners such as carboxyvinyl polymers, gelatin, gum arabic, polyvinyl alcohol, surfactants, fragrances, antioxidants, ultraviolet rays Absorbers, dyes, etc. should be added in appropriate proportions within the range that does not impair the effects of the present invention.
Can be blended.

The cosmetics of the present invention may be in any form as long as they can be applied to the skin, such as creams, lotions, and ointments.

Next, the present invention will be explained in more detail with reference to Examples. The present invention is not limited thereby. The blending amount is in weight%.

First, an example as a hair nourishing agent will be described, and then a test method will be explained.

Established. The subjects were those who pulled out a large number of hairs when washing their hair, and each group consisted of 20 people. The II period is 4 months, the first 2 months are a period of no cosmetics, the latter 2 months are a period of applying cosmetics, during this period you wash your hair once every 2 days, and wash your hair once a week.
Hair removed from each hair wash was collected and counted. The data on the number of hairs pulled out for a total of 8 times during the 2 months without application of cosmetics and the data on the number of hairs pulled out on a total of 8 times during the 2 months of application of cosmetics obtained in this way are summarized for each period and the average value is calculated. was evaluated according to the following criteria.

(Judgment criteria) Condition: The number of hairs pulled has decreased by more than 80.

10: The number of hairs pulled has decreased by 70 to 89.

±: The number of hair-pulled trees has decreased by 50 to 68.

-: The number of hairs pulled is reduced by 50.

(evaluation) O: 10, the percentage of 10 is 80% or more.

o: 10, the ratio of 10 is less than 50% to 80%.

Δ:+, the percentage of 10 is less than 30% to 50%.

X: +, the percentage of 10 is less than 30%.

(Left below) Examples 1 to 5, Comparative Examples 1 to 3 (Manufacturing method) 80 mol adduct of hydrogenated castor oil (EO) was dissolved in dipropylene glycol, and squalane, petrolatum, and isopropyl myristate were dissolved in advance by heating. Ubiquinone 10, ubiquinone 7, oxendrone, and tocopheryl acetate were added thereto and subjected to homomixer treatment. Next, ion-exchanged water was gradually added while stirring, and 95% ethanol in which a fragrance had been dissolved was added and mixed to obtain an emulsified cosmetic of A-Jeonbo.

As is clear from Table 1, the cosmetic composition of the present invention has an excellent hair-nourishing effect.

Furthermore, the therapeutic effect of the cosmetics according to the present invention on acne will be explained with reference to Examples. The blending amount is in weight%.

A method for measuring the effect will be described in Examples.

(Effect measurement method) A total of 10 men and women aged 15 to 32 with facial acne
After thoroughly washing the face with cosmetic soap, the sample was applied only on the skin 1 to 3 times a day.

Observations were made for the three symptoms of bloating, papules, and irritability, and the severity of each finding was graded into five grades: severe (4), moderate [(3) mild (2), slight (1), and none (0). It was evaluated separately. Follow-up observations were conducted before treatment, 1 week after treatment, 2 weeks after treatment, 3 weeks after treatment, and 4 weeks after treatment, and compared to before use, the degree of improvement in symptoms due to the sample used was significantly reduced (+1+), significantly reduced (廿), somewhat improved (+), unchanged (±), worsened (
-) was divided into five stages.

It is extremely useful to comprehensively judge the above observation progress (O)
, quite useful (○), somewhat useful (Δ), invalid (X) 4
Comprehensive evaluation was performed in stages.

(Leaving space below) Examples 6, 7, Comparative Example 4 Production method> ■~0 and 0~@ were heated and melted at 70@C''e, and part of ■@O was also added to this at 70℃. Add and mix the heated and dissolved ingredients, and emulsify with a homomixer.

① dissolved in the remainder of ＠ was added to this, and then ① was gradually added, and the mixture was processed with a homomixer to obtain an emulsion type cosmetic.

As is clear from Table 2, the cosmetics according to the present invention have excellent acne treatment effects.

Example 8 Stearyl alcohol
5.0 stearic acid
2.0 hydrogenated lanolin
2.0 squalane
6.0 Inpropyl myristate
4.0 Polyoxyethylene (25 mol) Cetyl alcohol ether 3+0 Glyceryl monostearate
2.0 ubiquinone 10
0.3 Oxendron
5.0 Propylene glycol 5.0
butyl paraben
0.2 dibutylhydroxytoluene
0.05 fragrance
0.5 io/exchange water
(To), 65 A cream cosmetic was obtained by manufacturing the above prescription ingredients by a conventional method. The obtained cosmetic has hair-nourishing effect,
□Excellent treatment effect for acne.

Claims (1)

[Claims] One or more compounds represented by the following general formula ▲ There are mathematical formulas, chemical formulas, tables, etc. ▼ (in the formula, n represents an integer from 7 to 10) and oxendrone are blended. Cosmetics characterized by: