CA1253807A - Topical composition for the protection and treatment of human skin or hair - Google Patents
Topical composition for the protection and treatment of human skin or hairInfo
- Publication number
- CA1253807A CA1253807A CA000491517A CA491517A CA1253807A CA 1253807 A CA1253807 A CA 1253807A CA 000491517 A CA000491517 A CA 000491517A CA 491517 A CA491517 A CA 491517A CA 1253807 A CA1253807 A CA 1253807A
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
- A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/925—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of animal origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Birds (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Emergency Medicine (AREA)
- Zoology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
ABSTRACT OF THE DISCLOSURE:
A topical composition for the protection, care and treatment of the human skin or human hair, which composition comprises from 1 to 50% by weight of triacyl-glycerols wherein the acyl portions are identical or different and represent a caprylyl radical or a capryl radical; from 0.8 to 40% by weight of lanolin alcohol, preferably solubilized in a solvent such as a mineral oil;
and from 1 to 50% by weight of squalene. The composition which may also comprise cosmetic and/or pharmaceutic additives, is particularly effective for moisturizing a dry skin. The composition is also effective for the treat-ment of eczema, atopic dermatitis, seborrheic dermatitis, ammoniacal dermatitis, sun erythema, pruritus, psoriasis and dyshidrosis.
A topical composition for the protection, care and treatment of the human skin or human hair, which composition comprises from 1 to 50% by weight of triacyl-glycerols wherein the acyl portions are identical or different and represent a caprylyl radical or a capryl radical; from 0.8 to 40% by weight of lanolin alcohol, preferably solubilized in a solvent such as a mineral oil;
and from 1 to 50% by weight of squalene. The composition which may also comprise cosmetic and/or pharmaceutic additives, is particularly effective for moisturizing a dry skin. The composition is also effective for the treat-ment of eczema, atopic dermatitis, seborrheic dermatitis, ammoniacal dermatitis, sun erythema, pruritus, psoriasis and dyshidrosis.
Description
BACXGROUND OF THE INVENTION:
a) field of_the invention The present invention relates to a topical composition for th~ protection, care and treatment of the human skin andfor hairO
b) technical back~round It is well known that newborn babies have a very soft and good looking skin. This is usually attributed to the protective properties of a natural eoating called ~vernix caseosa>~ that covers the ~oetuses during the last weeks of pregnancy. It is also known from gas chromatograms made on vernix collected ~rom pre-term (37 weeks) infants that the natural vernix is made of squalene, cholesterol, monoesters waxes, cholesteryl esters, tryglyceri~es and few other unidentified substances. (See S.J. Wysocki et al.
~IPIDS IN FOREHEAD VERNIX FROM NEWBORN INFANTS, Biol.
Nenonate 39: 300-304 (1981)).
SUMM~RY OF THE INVENT~ON:
An object of the present invention is to provide a topical, synthetic composition for use in protectin~, curing and/or treating the human skin and/or the human hair, which composition contains, as active ingredlents~ most of ~he~ major lngreclients Eound in the natural vernix caseosa.
Another obj(-~c~ oE the invention is to provide a cornposition which, in use, has very good moisturizing pro perties in addition of being effec~ive agains-t skin diseases such as eczema, atopic dermatitis, serborrheic dermatitis, ammoniacal dermatitisl sun erythema, pruritus (especially old person pruritus), psoriasis and dyshidrosis.
In accordance with the invention, these objects are achieved with a topical composition for the protection, care and treatment of h~nan skin or hair, which composition compriseso - from 1 to 50% by weight of triacylglycerols w 1 --`J~f~5~ 7 wherein the acyl portions are identical or different and represent a caprylyl radical or a capryl radical;
- from 0.8 to 40% by weight of lanolin alcohol ~preferably solubili~ed in a solvent such as a mineral oil);
- from l to 50% by weight of squalene; and - from O to 97,2% by weight of one or more cosmetically or pharmaceutically ~cceptable carrier. To the above-mentioned basic formulation may ~e added one or more pharmaceutical or cosmetical additives.
The topical composition according to the invention may have difEerent formulations depending on its expected use. By way of example, it ~ay be formulated as a body moisturizing lotion ~milk), as an oily gel for massage, as a cream (such as a night cream3, as an ointment, as a l.ip-stick~ as a hair preparation (such as a hair conditioner) or as an oil (such as a bath oil, an anti-weals and/or anti-wrinkle oil). Preferably, however, the topical composition will be formulated as a cre~m ~r an oil.
When the composition is formulated as an oil, it preferably contains from l to 50% by weight of triacyl-ylycerol 5 whexein the acyl portions are identlcal or diff0rent and repre~ent a caprylyl rad.ical or a capryl radical; from 0.8 to 40% by welght of lanol:Ln alcohol solubillzed in a tsufficlent amount of an acc~ptable ~olvent; and from 1 to 50% by w~ight of ~.qualene.
When the composition is formulated as a creamr it preferably contains from 1 to 16~ by weight of triacyl-glycerols wherein the acyl portions are identical or different and represent a caprylyl radical or a capryl radicall from 0.8~ to 12.8~ by weight of lanolin alcohol or 0.8 to 12.8% by weight of lanolin alcohol solubilized in a mineral oil (advantageousl~ l to 16~ by weight of a mixture consisting of 80% by weiyht of lanolin alcohol and of 20%
by weight of mineral oil3, and from l to 16% by weight of sclualene,in admix-ture with a suEEicient cluantity oE a cosmetical or pharmaceutical carxier. In this par-ticular case, the total amoun-t o~ txiacylglycerols, oE lanolin alcohol and oE squalene must be egal -to or lower than 17.8%
by weigh-t of the entire composition -to allow proper emulsion oE the oily phase wi-th the aqueous phase.
The above n~-rrtioned triacylglycerols IPreferabt.y-those sold uncter-~e-trade mark ~YRI~OL 318 and commonl~ called caprilic/capric trig]ycerides)have been specifically selec-ted by t,he Applicants in the basic formulation of tneir composition because:
- they are esters oE saturated Eatty acids, thereby avoiding the .risk oE oxidation;
- they are very dermophilic;
- they are very good solvent and are compa-tible with all the o-ther ingredients of -the composi-tion; and - -they have an-ti:Eungal proper-ties, especially against trichophyton~ and candida strains.
Lanol:Ln alcohol has been selected by the Appl:icants because o:E i-ts excellent emoll.ient propert~eC;.
~5 :Lanol:ln alco11ol, use can be macle oE tlle substance solcl 1lnder tt~e tr,~ade Irlr-l:rk ~i~EI~CE10t, [~-10 L, wtni.ch substance CO11;:i.StS oF an o:l:1.y m:i.xture oE 80~ by weight oE lanol.in a:Lco1lo:i. with 20~. by weight o~ a mlneral oii Squalene tpreEerably the one sold under the -trade mark SUPRAENE) has been selected by the Applicants because lt is a bactericide and it shows a very high aEEinity for the skin.
Tests conducted by the Applicants have surpris-i.nyly shown that the above-mentioned combination oE tri-acylglycerols wi-th lanolin alcohol and squalene, wi-th even-tually one or more cosmetical or pharmaceu-tical addi--tives has subs-tantially -the same hiyh mois-turizing and protec-tive properties as -the natural vernix caseosa, in ~'~53~V17 addition of having a remarkable efficiency against ~kin diseases such as eczema, atopic dermatitis, seborrheic dermatitis, ammoniacal dermatitis, sun erythema, pruritus (especially old person pruritus), psoriasis and dyshidrosis.
As cosmetical vr pharmaceutical additive or carrier use can advantageou~ly be made of water or of mineral oil ~preferably the heavy mineral oil sold under the trade mark RAMOL 350).
As all of the triacylglycerols, squalene and mixture of lanolin alcohol and mineral oil are oilsl they may be mixed together to define an oil composition without further association with a carrier~
As possible additives to the composition accord-ing to the invention, use can be made of one or more com-pounds selected from the following, non restrictive list:
- anti-oxydant agents - coloring or dying agents - emulsifying agents ~such as cholesterol, magnesium aluminum silicate, polyoxyethylene lauryl ether, polyoxyethylene ~onostearate, polyoxyethylene sorbitan monolaurate, propylene glycol monostearate, sodium borate plus fatty acid, ~odium lauryl sulfate~ sorbitan mono-palm:i.tate or triethanolami.ne plus fatty acid, and more particwlarly isopropyl myristate or the emulsiying wax sold under the txade mark POL~WAX NF) - perfuming agents (such as 4828-D : fleur arôme) - preservative agents ~such as cresol, propyl-paraben, methylparaben or sorbic acid) - Imiourea U.S.P. (sold under the trade mark GERMAL 115) ~ stabilizing or thickening agents ~such as carbomer, cetyl alcohol~ glyceryl monostearate, methyl-cellulose, spermaceti or stearyl alcohol) ~ 7 - tensio~active agents ~such as cholesterol).
Depending ~n its proposed used, the composition invention may also contain other active agents ~uch as:
- sun screen agents (such as octyl dimethyl p-amino benzoic acid) - ci.catrizing agents ~uch as a~lantoin) - anesthe~ic agents (Such as benzocaine) - antibiotic agents ~such as NEOSPORIN (trade mark) or neomycin) - costicosteroid agents (such as hydrocortisone~
- antifungal agents - antiseptic agent - keratolytic agents ~such as salicylic acid) - emollients (such as cholesterol) - occlusive emollients (such as the heavy mineral oil sold under the trade mark R~MOL-350).
When use is made o such additives, their amounts in the composition will be selected so th2t the composition contain l~ss than 8~ by weight (preferably 2 to 4~ of octyl dimethyl para amino benzoic acid; frQm 0.1 to 0.2~ by we.ight of all~ntoin; ox ~buut 0.5~ by weight of hydrocortisone.
Of course, the use o.E one or more of the above-mentionf~d other act.ive agents makes the composition usefu.l as sun ~creen, cicatrl~in~, antibiotic, corti.costeroid, antifungal, antiseptic, anesthesic and/or keratolytic com-position.
The following non-restrictive examples will illustrate preferred embodiments of the present invention.
E _ 1 - OIL coMro~ oN
An oil composition having the following formula-tion was prepared:
1~ 53~07 Weight with Weight in respect INGREDIENTS gramsto weight composi-tion Heavy mineral oil (RAMOL 350).......... 698.5 gr 69.85 %
Emulsifying agent lisopropyl myristate)............................. 100 gr 10.0 %
Squalene (SUPRAENE).................... 50 gr 5.0 %
Triacylglycerols ~MYRITOL 318)......... 100 gr 10.0 Lanolin alcohol (~MERCHOL L-101)....... 50 gr 5.0 %
Preservative agent (Propylparaben)..... 1.5 gr 0.15 %
_ 1000.0 gr 100.0 %
The above-mentioned oil composition was prepared by dissolving propylparaben in a part o~ the 698.5 yr oE
RAMOL 350. EleatincJ was ound necessary to d:Lssolv~3 propyl-paraben :i.n R~MOL 350. rl'he remr~:Lning par-t oE the 698.5 cJr oE RAMOr, 350 wa,L, subse~uerlt:ly added to the part contalniny the propyLparaben, together wi.th the SUPRAENE, MYRITOL 318 ancl AME'RCflOL L-:101. These inyredien-ts were mixed and then isopropyl myris-tate was added to the mixture. The result-ing mix-ture was well mixed until it appeared limpid.
A cream composition having the following formula-tion was prepared:
* caprilic/capric triglycerides sold under -the -trademark ~o~3~ ~
Weight %
with INGREDIENTS Weight in respec-t yrams -to -the weiyh-t composi-tion Squalene ~SUPRAENE)~ ....50 gr5.0 %
Triacylglycerols (MYRITOL 318)........... 30 gr 3.0 %
Lanolin alcohol IAMERCHOL L-lOlJ......... 30 gr 3.0 %
Emulsifying agent (POLAWAX NF)........... 80 gr 8.0 %
Stabilizing agent (Cetyl alcohol)........ 10 gr 1.0 %
Tensio-active agent (ChoLesterol)........ 1 gr 0.1 %
Preservative agent (Propylparaben)....... 1 gr 0.1 %
Preservative agent (Methylparaben)....... 2 gr 0.2 %
Imiourea U.S.P. (GERMALL 115)............ 4 gr 0.4 %
Glycerin................................. 80 gr 8.0 ~
~828 ~ Perfume (f:Leur arôme)............ :L gr 0.1 ~, Water~ 711 gr 71.1 ~
1000 gr 100.0 %
~
The above-mentioned cream composition was prepared by heating a first mixture of 80 gr of POLAWAX NF, 50 gr of SUP~AENE~ 30 gr oE MYRI~OL 318, 10 gr of cetyl alcohol, 1 gr of cholesterol, 30 gr of AMERCHOL L~101 and 1 gr of propylparaben a-t 75C. Then, a second mixture of 711 gr of wa-ter, 2 gr of me-thylparaben, 4 gr of GERMALL 115 and 80 gr oE glycerin was prepared ancl heated at 75C. The first mixture was poured in the second one under s-trong * caprilic/capric triqlycerides sold under the -trademark ;~2~:i3~
stirring for about 20 minutes. The resulting mixture was cooled to 55-60~C and 1 gr of 4828-D Perf~me (fleur arome) was added thereto. The so perfumed mixture was stirred and cooled to 30C. The cream was set to its final viscosity after 48 hours~
EXAMPLE 3 - PHARMACOLVGIC~ ~ESULT
Patients suffering of ecæema, atopic dermatitis and seborrheic dermatitis were treated with the cream composition of example 2 for several weeks. This composi-tion was used as unique therapeutic agent, and led to aclear improvement in khe healing of th~ cutaneous troubles of most of the patients. In particular, this com-position has substantially xeduc~d the necessity of using medicine containing steroids for the treatment of the L5 aforesaid pathologies. The composition has also shown good moisturizing property.
Several persons haviny been subjected to a face-lift some months ear~ier, were requested to use regularly the cream composition ~f example 2, and then been repetedly exposed to solar rays. The cream composition avoided wrinkling o the skin as is usually noted ~n such cases.
Ii'urthcrmore, the cre~m composLtlon of example 2 allowed fa5tQr heallng of dermabra~ions and provided skin moisturiz-ing of better quality.
a) field of_the invention The present invention relates to a topical composition for th~ protection, care and treatment of the human skin andfor hairO
b) technical back~round It is well known that newborn babies have a very soft and good looking skin. This is usually attributed to the protective properties of a natural eoating called ~vernix caseosa>~ that covers the ~oetuses during the last weeks of pregnancy. It is also known from gas chromatograms made on vernix collected ~rom pre-term (37 weeks) infants that the natural vernix is made of squalene, cholesterol, monoesters waxes, cholesteryl esters, tryglyceri~es and few other unidentified substances. (See S.J. Wysocki et al.
~IPIDS IN FOREHEAD VERNIX FROM NEWBORN INFANTS, Biol.
Nenonate 39: 300-304 (1981)).
SUMM~RY OF THE INVENT~ON:
An object of the present invention is to provide a topical, synthetic composition for use in protectin~, curing and/or treating the human skin and/or the human hair, which composition contains, as active ingredlents~ most of ~he~ major lngreclients Eound in the natural vernix caseosa.
Another obj(-~c~ oE the invention is to provide a cornposition which, in use, has very good moisturizing pro perties in addition of being effec~ive agains-t skin diseases such as eczema, atopic dermatitis, serborrheic dermatitis, ammoniacal dermatitisl sun erythema, pruritus (especially old person pruritus), psoriasis and dyshidrosis.
In accordance with the invention, these objects are achieved with a topical composition for the protection, care and treatment of h~nan skin or hair, which composition compriseso - from 1 to 50% by weight of triacylglycerols w 1 --`J~f~5~ 7 wherein the acyl portions are identical or different and represent a caprylyl radical or a capryl radical;
- from 0.8 to 40% by weight of lanolin alcohol ~preferably solubili~ed in a solvent such as a mineral oil);
- from l to 50% by weight of squalene; and - from O to 97,2% by weight of one or more cosmetically or pharmaceutically ~cceptable carrier. To the above-mentioned basic formulation may ~e added one or more pharmaceutical or cosmetical additives.
The topical composition according to the invention may have difEerent formulations depending on its expected use. By way of example, it ~ay be formulated as a body moisturizing lotion ~milk), as an oily gel for massage, as a cream (such as a night cream3, as an ointment, as a l.ip-stick~ as a hair preparation (such as a hair conditioner) or as an oil (such as a bath oil, an anti-weals and/or anti-wrinkle oil). Preferably, however, the topical composition will be formulated as a cre~m ~r an oil.
When the composition is formulated as an oil, it preferably contains from l to 50% by weight of triacyl-ylycerol 5 whexein the acyl portions are identlcal or diff0rent and repre~ent a caprylyl rad.ical or a capryl radical; from 0.8 to 40% by welght of lanol:Ln alcohol solubillzed in a tsufficlent amount of an acc~ptable ~olvent; and from 1 to 50% by w~ight of ~.qualene.
When the composition is formulated as a creamr it preferably contains from 1 to 16~ by weight of triacyl-glycerols wherein the acyl portions are identical or different and represent a caprylyl radical or a capryl radicall from 0.8~ to 12.8~ by weight of lanolin alcohol or 0.8 to 12.8% by weight of lanolin alcohol solubilized in a mineral oil (advantageousl~ l to 16~ by weight of a mixture consisting of 80% by weiyht of lanolin alcohol and of 20%
by weight of mineral oil3, and from l to 16% by weight of sclualene,in admix-ture with a suEEicient cluantity oE a cosmetical or pharmaceutical carxier. In this par-ticular case, the total amoun-t o~ txiacylglycerols, oE lanolin alcohol and oE squalene must be egal -to or lower than 17.8%
by weigh-t of the entire composition -to allow proper emulsion oE the oily phase wi-th the aqueous phase.
The above n~-rrtioned triacylglycerols IPreferabt.y-those sold uncter-~e-trade mark ~YRI~OL 318 and commonl~ called caprilic/capric trig]ycerides)have been specifically selec-ted by t,he Applicants in the basic formulation of tneir composition because:
- they are esters oE saturated Eatty acids, thereby avoiding the .risk oE oxidation;
- they are very dermophilic;
- they are very good solvent and are compa-tible with all the o-ther ingredients of -the composi-tion; and - -they have an-ti:Eungal proper-ties, especially against trichophyton~ and candida strains.
Lanol:Ln alcohol has been selected by the Appl:icants because o:E i-ts excellent emoll.ient propert~eC;.
~5 :Lanol:ln alco11ol, use can be macle oE tlle substance solcl 1lnder tt~e tr,~ade Irlr-l:rk ~i~EI~CE10t, [~-10 L, wtni.ch substance CO11;:i.StS oF an o:l:1.y m:i.xture oE 80~ by weight oE lanol.in a:Lco1lo:i. with 20~. by weight o~ a mlneral oii Squalene tpreEerably the one sold under the -trade mark SUPRAENE) has been selected by the Applicants because lt is a bactericide and it shows a very high aEEinity for the skin.
Tests conducted by the Applicants have surpris-i.nyly shown that the above-mentioned combination oE tri-acylglycerols wi-th lanolin alcohol and squalene, wi-th even-tually one or more cosmetical or pharmaceu-tical addi--tives has subs-tantially -the same hiyh mois-turizing and protec-tive properties as -the natural vernix caseosa, in ~'~53~V17 addition of having a remarkable efficiency against ~kin diseases such as eczema, atopic dermatitis, seborrheic dermatitis, ammoniacal dermatitis, sun erythema, pruritus (especially old person pruritus), psoriasis and dyshidrosis.
As cosmetical vr pharmaceutical additive or carrier use can advantageou~ly be made of water or of mineral oil ~preferably the heavy mineral oil sold under the trade mark RAMOL 350).
As all of the triacylglycerols, squalene and mixture of lanolin alcohol and mineral oil are oilsl they may be mixed together to define an oil composition without further association with a carrier~
As possible additives to the composition accord-ing to the invention, use can be made of one or more com-pounds selected from the following, non restrictive list:
- anti-oxydant agents - coloring or dying agents - emulsifying agents ~such as cholesterol, magnesium aluminum silicate, polyoxyethylene lauryl ether, polyoxyethylene ~onostearate, polyoxyethylene sorbitan monolaurate, propylene glycol monostearate, sodium borate plus fatty acid, ~odium lauryl sulfate~ sorbitan mono-palm:i.tate or triethanolami.ne plus fatty acid, and more particwlarly isopropyl myristate or the emulsiying wax sold under the txade mark POL~WAX NF) - perfuming agents (such as 4828-D : fleur arôme) - preservative agents ~such as cresol, propyl-paraben, methylparaben or sorbic acid) - Imiourea U.S.P. (sold under the trade mark GERMAL 115) ~ stabilizing or thickening agents ~such as carbomer, cetyl alcohol~ glyceryl monostearate, methyl-cellulose, spermaceti or stearyl alcohol) ~ 7 - tensio~active agents ~such as cholesterol).
Depending ~n its proposed used, the composition invention may also contain other active agents ~uch as:
- sun screen agents (such as octyl dimethyl p-amino benzoic acid) - ci.catrizing agents ~uch as a~lantoin) - anesthe~ic agents (Such as benzocaine) - antibiotic agents ~such as NEOSPORIN (trade mark) or neomycin) - costicosteroid agents (such as hydrocortisone~
- antifungal agents - antiseptic agent - keratolytic agents ~such as salicylic acid) - emollients (such as cholesterol) - occlusive emollients (such as the heavy mineral oil sold under the trade mark R~MOL-350).
When use is made o such additives, their amounts in the composition will be selected so th2t the composition contain l~ss than 8~ by weight (preferably 2 to 4~ of octyl dimethyl para amino benzoic acid; frQm 0.1 to 0.2~ by we.ight of all~ntoin; ox ~buut 0.5~ by weight of hydrocortisone.
Of course, the use o.E one or more of the above-mentionf~d other act.ive agents makes the composition usefu.l as sun ~creen, cicatrl~in~, antibiotic, corti.costeroid, antifungal, antiseptic, anesthesic and/or keratolytic com-position.
The following non-restrictive examples will illustrate preferred embodiments of the present invention.
E _ 1 - OIL coMro~ oN
An oil composition having the following formula-tion was prepared:
1~ 53~07 Weight with Weight in respect INGREDIENTS gramsto weight composi-tion Heavy mineral oil (RAMOL 350).......... 698.5 gr 69.85 %
Emulsifying agent lisopropyl myristate)............................. 100 gr 10.0 %
Squalene (SUPRAENE).................... 50 gr 5.0 %
Triacylglycerols ~MYRITOL 318)......... 100 gr 10.0 Lanolin alcohol (~MERCHOL L-101)....... 50 gr 5.0 %
Preservative agent (Propylparaben)..... 1.5 gr 0.15 %
_ 1000.0 gr 100.0 %
The above-mentioned oil composition was prepared by dissolving propylparaben in a part o~ the 698.5 yr oE
RAMOL 350. EleatincJ was ound necessary to d:Lssolv~3 propyl-paraben :i.n R~MOL 350. rl'he remr~:Lning par-t oE the 698.5 cJr oE RAMOr, 350 wa,L, subse~uerlt:ly added to the part contalniny the propyLparaben, together wi.th the SUPRAENE, MYRITOL 318 ancl AME'RCflOL L-:101. These inyredien-ts were mixed and then isopropyl myris-tate was added to the mixture. The result-ing mix-ture was well mixed until it appeared limpid.
A cream composition having the following formula-tion was prepared:
* caprilic/capric triglycerides sold under -the -trademark ~o~3~ ~
Weight %
with INGREDIENTS Weight in respec-t yrams -to -the weiyh-t composi-tion Squalene ~SUPRAENE)~ ....50 gr5.0 %
Triacylglycerols (MYRITOL 318)........... 30 gr 3.0 %
Lanolin alcohol IAMERCHOL L-lOlJ......... 30 gr 3.0 %
Emulsifying agent (POLAWAX NF)........... 80 gr 8.0 %
Stabilizing agent (Cetyl alcohol)........ 10 gr 1.0 %
Tensio-active agent (ChoLesterol)........ 1 gr 0.1 %
Preservative agent (Propylparaben)....... 1 gr 0.1 %
Preservative agent (Methylparaben)....... 2 gr 0.2 %
Imiourea U.S.P. (GERMALL 115)............ 4 gr 0.4 %
Glycerin................................. 80 gr 8.0 ~
~828 ~ Perfume (f:Leur arôme)............ :L gr 0.1 ~, Water~ 711 gr 71.1 ~
1000 gr 100.0 %
~
The above-mentioned cream composition was prepared by heating a first mixture of 80 gr of POLAWAX NF, 50 gr of SUP~AENE~ 30 gr oE MYRI~OL 318, 10 gr of cetyl alcohol, 1 gr of cholesterol, 30 gr of AMERCHOL L~101 and 1 gr of propylparaben a-t 75C. Then, a second mixture of 711 gr of wa-ter, 2 gr of me-thylparaben, 4 gr of GERMALL 115 and 80 gr oE glycerin was prepared ancl heated at 75C. The first mixture was poured in the second one under s-trong * caprilic/capric triqlycerides sold under the -trademark ;~2~:i3~
stirring for about 20 minutes. The resulting mixture was cooled to 55-60~C and 1 gr of 4828-D Perf~me (fleur arome) was added thereto. The so perfumed mixture was stirred and cooled to 30C. The cream was set to its final viscosity after 48 hours~
EXAMPLE 3 - PHARMACOLVGIC~ ~ESULT
Patients suffering of ecæema, atopic dermatitis and seborrheic dermatitis were treated with the cream composition of example 2 for several weeks. This composi-tion was used as unique therapeutic agent, and led to aclear improvement in khe healing of th~ cutaneous troubles of most of the patients. In particular, this com-position has substantially xeduc~d the necessity of using medicine containing steroids for the treatment of the L5 aforesaid pathologies. The composition has also shown good moisturizing property.
Several persons haviny been subjected to a face-lift some months ear~ier, were requested to use regularly the cream composition ~f example 2, and then been repetedly exposed to solar rays. The cream composition avoided wrinkling o the skin as is usually noted ~n such cases.
Ii'urthcrmore, the cre~m composLtlon of example 2 allowed fa5tQr heallng of dermabra~ions and provided skin moisturiz-ing of better quality.
Claims (13)
1. A topical composition for the protection, care and treatment of human skin or hair, characterized in that it comprises:
- from 1 to 50% by weight of triacylglycerols wherein the acyl portions are identical or different and represent a caprylyl radical or a capryl radical, - from 0.8 to 40% by weight of lanolin alcohol, and - from 1 to 50% by weight of squalene, the balance consisting of at least one cosmetical or pharmaceutical additive or carrier.
- from 1 to 50% by weight of triacylglycerols wherein the acyl portions are identical or different and represent a caprylyl radical or a capryl radical, - from 0.8 to 40% by weight of lanolin alcohol, and - from 1 to 50% by weight of squalene, the balance consisting of at least one cosmetical or pharmaceutical additive or carrier.
2. A topical composition according to claim 1, characterized in that it comprises from 1 to 16% by weight of triacylglycerols wherein the acyl portions are identical or different and represent a caprylyl radical or a capryl radical; from 0.8 to 12.8% by weight of lanolin alcohol and from 1 to 16% by weight of squalene, the total concen-tration of said substances in said composition being equal to or smaller than 17.8% by weight.
3. A topical composition according to claim 2, characterized in that it further contains one or more additives selected from the group consisting of antioxidant agents, coloring and dying agents, emulsifying agents, perfuming agents, preservative agents, tensioactive agents, stabilizing agents and thickening agents.
4. A topical composition according to claim 3, characterized in that it further contains one or more other active agents selected from the group consisting of sun screen agents, cicatrizing agents, anesthesic agents, antibiotic agents, corticosteroid agents, antifungal agents, antiseptic agents, hydratation agents, keratolytic agents, emollients agents and occlusive emollient agents.
5. A topical composition according to claim 1, characterized in that it further contains one or more additives selected from the group consisting of antioxidant agents, coloring or dying agents, emulsifying agents, perfuming agents, preservative agents, tensio-active agents, stabilizing agents and thickening agents; and one or more other active agents selected from the group consisting of sun screen agents, cicatrizing agents, anesthesic agents, antibiotic agents, corticosteroid agents, antifungal agents, antiseptic agents, hydratation agents, keratolytic agents, emollients agents and occlusive emollient agents.
6. A topical composition according to claim 5, characterized in that said other active agent is octyl dimethyl para-aminobenzoic acid in a concentration lower than 8% by weight of the total weight of said composition.
7. A topical composition according to claim 5, characterized in that said other active agent is octyl dimethyl para-aminobenzoic acid in a concentration varying from 2 to 4% by weight of the total weight oE said composi-tion.
8. A topical composition according to claim 5, characterized in that said other active agent is allantoin in a concentration varying from 0.1 to 0.2% by weight of the total weight of said composition.
9. A topical composition according to claim 5, characterized in that said other additive agent is hydro-cortisone in a concentration of about 0.5% by weight of the total weight of said composition.
10. A topical composition according to claim 5, characterized in that said other active agent is benzocaine.
11. A topical composition according to claim 5, characterized in that said other active agent is salicylic acid.
12. A topical composition according to claim 1, characterized in that it is formulated as an oil and con-sists of:
% by weight - Triacylglycerols as defined in claim 1.............. 10 %
- Mixture of 80% by weight of lanolin alcohol and 20% by weight of mineral oil..................... 5 %
- Squalene............................................. 5 %
- Isopropyl Myristate (additive)...................... 10 %
- Propylparaben (additive)........................ 0.15%
- Mineral oil (carrier).......................... 69.85%
% by weight - Triacylglycerols as defined in claim 1.............. 10 %
- Mixture of 80% by weight of lanolin alcohol and 20% by weight of mineral oil..................... 5 %
- Squalene............................................. 5 %
- Isopropyl Myristate (additive)...................... 10 %
- Propylparaben (additive)........................ 0.15%
- Mineral oil (carrier).......................... 69.85%
13. A topical composition according to claim 1, characterized in that it is formulated as a cream and consists of:
% by weight - Triacylglycerols as defined in claim 1 ....... 3 %
- Mixture of 80% by weight of lanolin alcohol and 20% by weight of mineral oil............... 3 %
Squalene............................. 5 %
Glycerin (active agent)......................... 8 %
- Cholesterol (active agent)........................ 0.1 %
- Emulsifying wax (additive)......................... 8 %
% by weight - Cetyl alcohol (additive)......................... 1 %
- Propylparaben (additive)......................... 0.1 %
- Methylparaben (additive)......................... 0.2 %
- Imiourea U.S.P. (additive)....................... 0.4 %
- Perfume (additive)............................... 0.1 %
- Water (carrier).................................. 71.1%
% by weight - Triacylglycerols as defined in claim 1 ....... 3 %
- Mixture of 80% by weight of lanolin alcohol and 20% by weight of mineral oil............... 3 %
Squalene............................. 5 %
Glycerin (active agent)......................... 8 %
- Cholesterol (active agent)........................ 0.1 %
- Emulsifying wax (additive)......................... 8 %
% by weight - Cetyl alcohol (additive)......................... 1 %
- Propylparaben (additive)......................... 0.1 %
- Methylparaben (additive)......................... 0.2 %
- Imiourea U.S.P. (additive)....................... 0.4 %
- Perfume (additive)............................... 0.1 %
- Water (carrier).................................. 71.1%
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA000491517A CA1253807A (en) | 1985-09-25 | 1985-09-25 | Topical composition for the protection and treatment of human skin or hair |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA000491517A CA1253807A (en) | 1985-09-25 | 1985-09-25 | Topical composition for the protection and treatment of human skin or hair |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1253807A true CA1253807A (en) | 1989-05-09 |
Family
ID=4131468
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000491517A Expired CA1253807A (en) | 1985-09-25 | 1985-09-25 | Topical composition for the protection and treatment of human skin or hair |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA1253807A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991007167A1 (en) * | 1989-11-09 | 1991-05-30 | Schering-Plough Healthcare Products, Inc. | Protein kinase activators as enhancers of melanin production |
| EP0467218A2 (en) * | 1990-07-17 | 1992-01-22 | Beiersdorf Aktiengesellschaft | Combinations of active agents for skin care |
| WO1993007847A1 (en) * | 1991-10-15 | 1993-04-29 | Kenneth Vincent Mason | Anti-seborrhoeic formulation |
| FR2693370A1 (en) * | 1992-07-08 | 1994-01-14 | Melin Gisele | Ointment contg. pure lambs' suet, methyl salicylate - and spirit of lavender, for application to scalp to prevent hair loss and promote re-growth |
| EP0775486A1 (en) * | 1995-11-23 | 1997-05-28 | Beiersdorf Aktiengesellschaft | Antibacterial, antimycotic and antviral compositions based on alpha-hydroxyalkanoic acids and squalene |
| FR2885491A1 (en) * | 2005-05-16 | 2006-11-17 | Inneov Lab | Use of glyceride with average chain for the preparation of an oral and/or parenteral composition to prevent and/or treat dryness and/or fragile keratinous matter |
-
1985
- 1985-09-25 CA CA000491517A patent/CA1253807A/en not_active Expired
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991007167A1 (en) * | 1989-11-09 | 1991-05-30 | Schering-Plough Healthcare Products, Inc. | Protein kinase activators as enhancers of melanin production |
| EP0467218A2 (en) * | 1990-07-17 | 1992-01-22 | Beiersdorf Aktiengesellschaft | Combinations of active agents for skin care |
| EP0467218A3 (en) * | 1990-07-17 | 1993-03-03 | Beiersdorf Aktiengesellschaft | Combinations of active agents for skin care |
| WO1993007847A1 (en) * | 1991-10-15 | 1993-04-29 | Kenneth Vincent Mason | Anti-seborrhoeic formulation |
| AU666139B2 (en) * | 1991-10-15 | 1996-02-01 | Kenneth Vincent Mason | Anti-seborrhoeic formulation |
| FR2693370A1 (en) * | 1992-07-08 | 1994-01-14 | Melin Gisele | Ointment contg. pure lambs' suet, methyl salicylate - and spirit of lavender, for application to scalp to prevent hair loss and promote re-growth |
| EP0775486A1 (en) * | 1995-11-23 | 1997-05-28 | Beiersdorf Aktiengesellschaft | Antibacterial, antimycotic and antviral compositions based on alpha-hydroxyalkanoic acids and squalene |
| FR2885491A1 (en) * | 2005-05-16 | 2006-11-17 | Inneov Lab | Use of glyceride with average chain for the preparation of an oral and/or parenteral composition to prevent and/or treat dryness and/or fragile keratinous matter |
| WO2007000529A2 (en) * | 2005-05-16 | 2007-01-04 | Laboratoires Inneov | Treating keratinous dryness using glycerides |
| WO2007000529A3 (en) * | 2005-05-16 | 2007-07-12 | Inneov Lab | Treating keratinous dryness using glycerides |
| JP2008540621A (en) * | 2005-05-16 | 2008-11-20 | ラボラトワール イネオフ | Treatment of keratinous drying with glycerides |
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