JP3496896B2 - Hair restorer and hair cosmetic - Google Patents

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to the root root of pearl millet.
A hair nourishing agent or a hair cosmetic composition comprising 0.01 to 0.2% by weight of a tanol extract, which promotes hair growth and hair growth, and exerts effective effects for treatment of alopecia and improvement of thinning hair. It is a thing.

[0002]

2. Description of the Related Art Now that the aging of the population is progressing and the social environment is undergoing major changes, combined with the increase of stress in daily life, people who are worried about hair loss and thinning hair are not limited to the conventional middle-aged and older people. The demand for hair nourishing agents and hair nourishing cosmetics has greatly increased as it has spread to younger age groups and women. In contrast,
Various types of hair nourishing agents have been provided.

[0003] Conventional hair nourishing / hair-growth agents or hair cosmetics include carpronium chloride, cembly extract, capsicum tincture, cepharanthin, protracted herb extract, ginseng extract,
Compounds such as vitamin E derivatives that promote blood circulation in the scalp, pantothenyl alcohol, pantothenyl ethyl ether, mononitroguaiacol, Photosensitizer No. 301, placenta extract, biotin, carrot extract, etc. and hair matrix cells Activator, ethinyl estradiol, royal jelly, glycyrrhetinic acid, pyridoxine hydrochloride, radisic acid, kashi extract to suppress sebum line activity, hinokitiol, diphenhydramine hydrochloride,
Glycyrrhizic acid or the like having a bactericidal action or anti-inflammatory action, resorcin, salicylic acid or the like having a keratolytic action, sodium pyrrolidonecarboxylate,
A mixture of Sasanishiki extract, hyaluronic acid, Cordyceps sinensis extract, Duke extract, etc., mainly for moisturizing effect, inositol, L-serine, L-threonine, N-acetyl-L-
Some include methionine, etc., as the main effect of nutritional supplementation.

Further, various substances that inhibit testosterone-5α-reductase, which converts the male hormone testosterone into the active form dihydrotestosterone, have been reported, and many hair restorers and hair restorers containing them have been reported. . Furthermore, recently, new hair-growing ingredients such as maikai flowers, ginkgo biloba extract, and dialkylmonoamine derivatives have been applied.

However, many of the above-mentioned conventionally used hair nourishing components do not have sufficient hair growth promoting effect or hair growth promoting effect, and when an effective amount is added, skin irritation and sensitization are preferably expressed. Some had no impact.
In addition, there is a marked difference in the decline of hair growth depending on the age and type of alopecia, and the cause of alopecia also varies slightly from person to person.Therefore, there are individual differences in the actual effects of hair nourishing and hair growth agents. It was great. Further, there are many cases where the compatibility with a hair nourishing agent, a base for hair cosmetics, a solvent, etc. is poor, and there is a problem with stability in the preparation.

[0006]

DISCLOSURE OF THE INVENTION The present invention contains a hair nourishing component that effectively promotes hair growth and hair growth with a small amount of the mixture, and does not cause irritation to the scalp or skin sensitization. Another object of the present invention is to provide a more stable hair nourishing agent or hair cosmetic composition. Furthermore, it is an object of the present invention to obtain a hair nourishing agent which shows good treatment and improvement effects on alopecia and thinning hair of various forms caused by various factors.

[0007]

[Means for Solving the Problems] In order to solve the above problems, the present inventors have screened hair nourishing ingredients, and found that Coix seed extract has an excellent hair follicle activating effect. Has been completed.

Coix lachryma-jobi is an extract of Coix lachryma-jobi, which is a base plant of Yokuinin which is a crude drug.
L. var. Ma-yuen (Roman) Stapf.) Is made into about 1 to 2 cm of bean sprouts, and the roots are crushed, immersed in ethanol for extraction, and then concentrated to prepare. The extract obtained by this method contains 1,000 μg / 100 g or more of coixol having physiological activities such as analgesic, antispasmodic and muscle relaxing effects.

[0009] Next, the hair follicle activating action of the Coix seed extract prepared by the above method will be described. The hair follicle activation action was measured by the MTT method using mouse hair follicle-derived cultured cells. That is, hair follicle cells separated and collected from 4-day-old ICR mouse skin were washed and treated with trypsin, and then plated on a collagen-coated plate at 1 × 10 5 cells per well, and streptomycin 1 was added.
Dulbecco's modified basal medium (DM with 100 μg / ml, 100 IU / ml penicillin and 10% fetal bovine serum)
The cells were cultured in EM) for 24 hours in the air containing 5% carbon dioxide gas. Then, the medium was treated with insulin 5 μg / ml, epidermal growth factor (EGF) 5 ng / ml, hydrocortisone 0.5.
MCDB153 high amino acid medium containing μg / ml, 0.03 mM calcium ion and an extract of Coix ginseng with 50% by weight of ethanol was exchanged and incubated, and on the 4th day, hair follicle activity was measured by the MTT method and activated. It is represented by an index. The activation index is the activity of the mitochondria of cells when the extract of Coix seeds is added, divided by the activity of the control. The case where a 50 wt% ethanol aqueous solution was added at the same concentration was used as a control.

The MTT method uses 2- (4,5-dimethyl-2-
Thiazolyl) -3,5-diphenyltetrazolium bromide (MTT) 0.4 mg / ml was added and incubated at 37 ° C. for 2 hours, and then 2-propanol 2 was obtained from hair follicle cells.
Formazan was extracted with 00 μl and 550 nm and 650
The difference in nm absorption is measured.

By changing the addition concentration of Coix seeds,
The results of determining the dose response are shown in Table 1. From Table 1, it is almost 1.19 when 0.04 to 0.08% by weight is added.
Twice, the addition of 0.16% by weight showed 1.27 times the activation of hair follicle cells, and the addition of a low concentration showed a considerably high hair follicle activation action. When the results shown in Table 1 are shown in FIG. 1, a maximum value was observed in the dose response curve for the hair follicle cell activating action of the coix seed, and hair follicle activity was observed at about 0.16% by weight. The chemical action becomes the maximum.

[Table 1]

[0012]

[Function] As described above, Coix seed extract has a high activating effect on hair follicle cells, and a hair nourishing agent or a hair cosmetic containing a small amount of this extract promotes hair growth by activating the hair follicles, thus promoting hair growth. Can be promoted. The amount to be added to the hair nourishing agent or the cosmetic for hair is not particularly limited, but 0.01
Even if added in a small amount of about 0.2% by weight, a sufficient hair growth and hair growth promoting effect can be exhibited.

The hair nourishing agent of the present invention can be provided in various forms such as lotions, milky liquids, creams and the like, and hair cosmetics are also available as hair art, hair liquid, hair lotion, hair cream, It can be provided in the form of hair rinse, shampoo, hair set lotion, hair set spray, hair pack and the like.

[0014]

EXAMPLES The present invention will be described in more detail with reference to Examples. The formulations of the examples of the present invention are shown below. In addition, in the following examples, the extract of Coix seeds was 50% by volume aqueous ethanol solution.

[Example 1] Hair tonic (1) Coix seed extract 0.2 (% by weight) (2) Tocopherol acetate 1.0 (3) Glycerin 3.0 (4) l-Menthol 0.1 ( 5) Fragrance 0.2 (6) Methyl paraoxybenzoate 0.1 (7) Ethanol 60.0 (8) Purified water 35.4 (7) and (8) are mixed, and (1) to (6 ) Are sequentially added, mixed and dissolved to prepare.

[Example 2] Milk liquid hair nourishing agent (1) Beeswax 3.0 (wt%) (2) Liquid paraffin 20.0 (3) Microcrystalline wax 5.0 (4) Behenyl alcohol 1.3 (5) Isooctane Cetyl acid 10.0 (6) Polyoxyethylene (20) Behenyl ether 2.0 (7) Polyoxyethylene (40) sorbitan 1.0 Tetraoleate (8) Glycerin monostearate 2.0 (9) Tocopherol acetate 1.0 (10) Coix seed extract 0.2 (11) 1,3-butylene glycol 5.0 (12) Methyl paraoxybenzoate 0.1 (13) Perfume 0.1 (14) Purified water 49.3 The oil phase components (1) to (9) are heated to 75 ° C. and uniformly mixed and dissolved. To this are added (11), (12) and (14) previously mixed and dissolved and heated to 75 ° C., mixed, stirred and pre-emulsified, and then emulsified with a homomixer. Then cool, 4
Add (10) and (13) at 0 ° C. and mix.

[Example 3] Hair nourishing cream (1) Stearic acid 4.00 (% by weight) (2) Cetanol 3.00 (3) Liquid paraffin 25.00 (4) Paraffin 4.00 (5) Avocado oil 5.00 (6) Beef fatty acid triglyceride 10.00 (7) Silicone oil 0.20 (8) Polyoxyethylene (20) Behenyl ether 1.50 (9) Polyoxyethylene (60) sorbitan 1.00 Tetraoleate (10) Glycerin monostearate 1.50 (11) Tocopherol acetate 1.00 (12) Coix seed extract 0.15 (13) 1,3-Butylene glycol 5.00 (14) Methyl paraoxybenzoate 0.10 (15) Perfume 0.10 (16) Purified water 38.45 Oil phase components of (1) to (11) are heated to 75 ° C. and uniformly mixed,
Dissolve. To this are added (13), (14) and (16) previously mixed and dissolved and heated to 75 ° C., mixed, stirred and pre-emulsified, and then emulsified by a homomixer. Then cool down,
Add (12) and (15) at 40 ° C. and mix.

[0018]   [Example 4] Hair lotion     (1) Sodium lactate 0.05 (wt%)     (2) Ethanol 10.00     (3) Coix seed extract 0.15     (4) Perfume 0.05     (5) Methyl paraoxybenzoate 0.10     (6) Purified water 89.65 Prepare by mixing, dissolving and homogenizing (1) to (6).

Example 5 Hair Liquid (1) Polyoxypropylene (40) butyl 25.00 (wt%) Ether Phosphoric Acid (2) Polyoxypropylene (40) Butyl Ether 10.00 (3) Triethanolamine 1 0.00 (4) Sodium hyaluronate 0.05 (5) Coix seed extract 0.05 (6) Ethanol 30.00 (7) Perfume 0.20 (8) Methyl paraoxybenzoate 0.10 (9) Purified water 33.60 (1) ~ (3), (6), (8) and (9) are mixed, dissolved and homogenized, (4), (5) and (7) are added and mixed Prepare.

Example 6 Hair Conditioner (1) Liquid Paraffin 1.50 (wt%) (2) Lanolin Alcohol 0.50 (3) Vaseline 1.50 (4) Cetanol 2.00 (5) Monostearic Acid Glycerin 2.00 (6) Polyethylene glycol stearate (100) 1.50 (7) Polyoxyethylene (10) Octyl ether 1.00 (8) Polypropylene glycol (20) Methyl 1.00 Glucose ether (9) Polyoxy Ethylene (10) Octyl 0.40 Phenyl ether (10) Tocopherol acetate 1.00 (11) Xanthan gum 0.20 (12) Hydrolyzed collagen 3.00 (13) Stearyltrimethylammonium chloride 5.00 (14) Citric acid 0 10 (15) Coix seed extract 0.06 (16) 1,3-butylene glycol 5.00 (17) Methyl paraoxybenzoate 0.10 (18) Fragrance 0.10 (19) uniformly mixed oil phase components were heated to 75 ° C. in purified water 74.04 (1) to (10),
Dissolve. To this, add (11), (13), (14), (16), (17) and (19) that were mixed and dissolved in advance and heated to 75 ° C, mix, stir and pre-emulsify, then homomixer Emulsify in. Then, the mixture is cooled and (12), (15) and (18) are added and mixed at 40 ° C.

Example 7 Hair Styling Gel (1) Polyvinylpyrrolidone 2.00 (wt%) (2) Polyoxyethylene (24) Cholesteryl 1.00 (3) Hydrolyzed Collagen 1.00 (4) Triethanol Amine 1.00 (5) Purified water 35.00 (6) Coix seed extract 0.04 (7) Methyl paraoxybenzoate 0.10 (8) Carboxyvinyl polymer 1.00 (9) Purified water 58.86 ( After dissolving 1) in (5), add (2)-(4) and (7), and heat to dissolve (A). Next, (8) is dispersed in (9) with stirring and dissolved (B). After adding (6) to (A), (B) is gradually added with gentle stirring to cause gelation.

[Example 8] Hair rinse (1) Stearyl trimethyl ammonium chloride 3.00 (wt%) (2) Distearyl dimethyl ammonium chloride 2.00 (3) Behenyl alcohol 2.50 (4) 2-octyldodecanol 1.00 (5) Polyoxyethylene (2) oleyl ether 2.00 (6) Silicone oil 0.20 (7) Coix seed extract 0.03 (8) Cationized cellulose 10% aqueous solution 2.00 (9) 1,3-butylene glycol 3.00 (10) Methyl paraoxybenzoate 0.10 (11) Perfume 0.10 (12) Colorant 0.10 (13) Purified water 83.97 (1) to (6) The oil phase components are heated to 75 ° C. to uniformly mix and dissolve. To this, (8) to (10) and (13) previously mixed and dissolved and heated to 75 ° C. are added, mixed, stirred and pre-emulsified, and then emulsified by a homomixer. Then cool, 4
Add (7), (11) and (12) at 0 ° C. and mix.

Example 9 Hair Shampoo (1) Polyoxyethylene (3) Lauryl Sulfate 12.0 (wt%) Triethanolamine (2) Lauryl Sulfate Triethanolamine 6.0 (3) Lauroyldiethanolamide 6. 0 (4) Sodium chloride 0.1 (5) Citric acid 0.1 (6) Coix seed extract 0.1 (7) Methyl paraoxybenzoate 0.1 (8) Perfume 0.1 (9) Purified water 75 .5 (1) to (5), (7) and (9) are mixed, dissolved and homogenized, and (6) and (8) are added and mixed.

Example 10 Hair Treatment (1) Stearyldimethylbenzyl chloride 2.00 (% by weight) Ammonium (2) Behenyl alcohol 8.00 (3) Lanolin 1.00 (4) 2-octyldodecanol 6.00 (5) Cetyl isooctanoate 4.00 (6) Polyoxyethylene (7) oleyl ether 2.00 (7) Coix seed extract 0.08 (8) 1,3-Butylene glycol 5.00 (9) Paraoxybenzoic acid Methyl acid 0.10 (10) Perfume 0.10 (11) Colorant 0.10 (12) Purified water 71.62 The oil phase components of (1) to (6) are heated to 75 ° C. and uniformly mixed, Dissolve. To this, (8), (9) and (12) previously mixed and dissolved and heated to 75 ° C. are added, mixed, stirred and pre-emulsified, and then emulsified by a homomixer. Then cool and 40
Add (7), (10) and (11) at ℃ and mix.

Of the embodiments of the present invention described above, Embodiment 1
-Example 6 was tested for human use. In Examples 1 to 6, the extract of Coix seed is 5
Comparative examples 1 to 1 in which 0% by volume aqueous ethanol solution was substituted
As Comparative Example 6, a male panelist 3 with thin hair and hair loss
One group consisted of 0 persons, and each group was allowed to use the examples and comparative examples. Appropriate amounts of these samples were applied twice a day in the morning and evening to the area where thin hair or hair loss was concerned, and were continuously used for 6 months. For each panelist, the degree of hair loss before and after the test, the hair growth and vellus hair growth were observed, and the degree of improvement of thinning hair and hair loss symptoms was evaluated based on each observation. The evaluation was performed in four levels of "moderate or higher improvement", "slight improvement", "unchanged" and "deterioration", and the number of panelists obtained each evaluation
It was shown to.

[Table 2]

In Table 2, improvement in thinning hair and alopecia were observed in all the groups used in Examples of the present invention, and in particular, Example 1 of the present invention containing 0.15 to 0.2% by weight of Coix seed extract. -In the group used in Example 4, 43% to 60% of the panelists showed a moderate improvement or more. In addition, even in the use groups of Example 5 and Example 6 in which the compounding amounts of Coix seeds are as small as 0.05% by weight and 0.06% by weight, the improvement of a moderate degree or more is achieved in the panelists of 13% and 20%. Was being watched. On the other hand, in the group using the comparative example, most of the panelists did not show any change in the symptoms, and some panelists had the symptoms worsened.

Further, during the above-mentioned use test period, none of the panelists who felt itchiness or irritation or redness or swelling of the scalp was observed in any of the groups used in the examples. Furthermore, in any of the examples, no change in the state of the preparation such as sedimentation of the contained components or phase separation was observed.

[0028]

INDUSTRIAL APPLICABILITY As described in detail above, the present invention can provide a hair nourishing agent and a hair cosmetic composition which are excellent in safety and stability and have an effective hair growth and hair growth promoting effect. In addition, since the hair nourishing agent and the hair cosmetic composition according to the present invention have activation of hair follicle cells as a mechanism of action, they can effectively prevent and improve thinning hair and alopecia caused by various factors.

[Brief description of drawings]

FIG. 1 is a diagram showing a dose response regarding the hair follicle cell activating action of an extract of Coix ginseng.

─────────────────────────────────────────────────── ─── Continuation of front page (72) Inventor Tadashi Okada No. 1 Numata, Kitakata-cho, Ichinomiya-shi, Aichi Prefecture Oriza Yuka Co., Ltd. (72) Inventor Hiromichi Murai 1 Numata, Kitakata-cho, Ichinomiya-cho, Aichi Prefecture Address within Oriza Yuka Co., Ltd. (56) Reference JP-A-52-156936 (JP, A) JP-A-53-15432 (JP, A) JP-A-60-174706 (JP, A) JP-A 60-146829 (JP, A) JP-A-4-342535 (JP, A) JP-A-6-22726 (JP, A) JP-A-2-270825 (JP, A) JP-A-6-298695 (JP, A) (58) Fields surveyed (Int.Cl. ⁷ , DB name) A61K ^7/ 00-7/50 A61K 35/78

Claims (2)

(57) [Claims] 1. A hair nourishing agent comprising 0.01 to 0.2% by weight of an ethanol extract of Coix root . 2. A hair cosmetic composition comprising 0.01 to 0.2% by weight of an ethanol extract of Coix root .