JPH11302128A - Cosmetic for scalp and hair - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject cosmetic having excellent hair-restoring effect, depilation-preventing effect and dandruff and itching-preventing effect and excellent in safety by including glycyrrhetinic acids, glycyrrhizic acids and Cuachalalate extract. SOLUTION: This cosmetic comprises (A) glycyrrhetinic acid (β-glycyrrhetinic acid) (aglycon of glycyrrhetinic acid extracted from Glycyrrhiza glabra L.var.) (e.g. glycyrrhetinic acid glycerol) and/or glycyrrhizic acids (glycoside extracted from Glycyrrhiza glabra L.var. and comprising 1 mol glycyrrhetinic acid and 2 mol glucuronic acid) and (B) Cuachalalate extract. In the above cosmetic, the component A is preferably contained in an amount of 0.001-5.0 wt.% and the component B is preferably contained in an amount of 0.0001-20.0 wt.%.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a scalp hair cosmetic (hereinafter referred to as "hair cosmetic"). More specifically, the present invention relates to a cosmetic for hair which has an excellent hair-growing effect, an anti-hair loss effect, an anti-dandruff and itching effect, and is also excellent in safety. Used in the field of cosmetics or cosmetics.

[0002]

2. Description of the Related Art There are various types of hair cosmetics.
There are products for various scalp hair conditions. For example, products have been developed that can prevent hair loss and the like by preventing dandruff and itching on the scalp. Various problems on the scalp are increasing with the increasing social stress in today's aging society.
The demand for hair cosmetics that responds to this problem on the scalp is increasing rapidly. In general, causes of baldness and hair loss on the head include activation of androgens in organs such as the sebaceous glands above the hair follicles, insufficient supply of nutrients due to a decrease in blood flow to the hair papilla and hair follicles, and corneal epithelium. Excessive dandruff, excessive sebum secretion, production of lipid peroxide, stress, and the like due to malformation and the like. In addition, in order to grow durable and beautiful hair, it is important to provide sufficient nutrition to the nipples and hair follicles. A decrease in blood flow to the dermal papilla or hair follicle causes nutritional deficiency and a decrease in the function of excreting waste products, and causes fine hair and thin hair.

[0003] From such a viewpoint, improvement of excessive sebum secretion in the scalp is an indispensable point in solving troubles of the scalp and hair. Conventional hair cosmetics generally contain a substance having an action of removing or reducing factors considered to be causes of baldness, hair loss and the like as described above. For example, to improve blood circulation in the scalp, assembly extract, vitamin E
And its derivatives, acetylcholine derivatives, blood flow promoters such as cepharanthin, local stimulants such as pepper tincture, and anti-inflammatory agents such as purple root extract to suppress scalp inflammation caused by excessive sebum secretion. A female hormone agent such as estradiol is compounded to suppress male hormones, an antibacterial agent such as salicylic acid is mixed to prevent dandruff, and serine and methionine are added to supply nutrition to hair follicles and the like. Amino acids, vitamins and the like are blended and used for the prevention and treatment of baldness, hair loss, hair thinning and the like.

[0004]

However, it is difficult to obtain a sufficient effect even if only a small amount of these components is incorporated into cosmetics for hair. There was a strong tendency to be accompanied by a tingling sensation and redness, and the blending amount was naturally limited.

The problem to be solved by the present invention is to provide a cosmetic for hair which has excellent effects and is also excellent in safety.

[0006]

Means for Solving the Problems The present inventor has made intensive studies to solve this problem. As a result, by combining a specific anti-inflammatory agent with the quacharate extract, it has an excellent hair-growing effect, an anti-hair loss effect, and an itching and dandruff-preventing effect for the scalp, and is also excellent in safety. The present inventors have found that a cosmetic is provided and completed the present invention.

[0007] That is, the present invention is an invention which provides a cosmetic for hair containing glycyrrhetinic acids and / or glycyrrhizic acids, and quacharate extract.

[0008]

Embodiments of the present invention will be described below. The hair cosmetic composition of the present invention is a hair cosmetic composition exhibiting a desired effect by combining a glycyrrhetinic acid and / or glycyrrhizic acid with a quacharate extract solution.

The glycyrrhetinic acids and glycyrrhizic acids to be incorporated in the cosmetic for hair of the present invention will be described. In the present invention, glycyrrhetinic acids mean glycyrrhetinic acid and glycyrrhetinic acid derivatives.

Glycyrrhetinic acid (β-glycyrrhetinic acid) is an aglycone of glycyrrhizic acid extracted from licorice and is a triterpenoid compound belonging to the β-amylin system and is known as an anti-inflammatory agent. Methods for producing glycyrrhetinic acid are known and commercially available. Also,
Examples of the glycyrrhetinic acid derivative include glyceryl glyceryl retinate, stearyl glycyrrhetinate, pyridoxine glycyrrhetinate, and glycyrrhetinyl stearate. These production methods are known and are all commercially available.

In the present invention, glycyrrhizic acids are
It means glycyrrhizic acid and glycyrrhizic acid derivatives. Glycyrrhizic acid is extracted from licorice,
A glycoside consisting of moles of glycyrrhetinic acid and 2 moles of glucuronic acid, which is known as an anti-inflammatory agent. Methods for producing glycyrrhizic acid are known and commercially available.

Further, glycyrrhizic acid derivatives include:
For example, trisodium glycyrrhizinate, dipotassium glycyrrhizinate, methyl glycyrrhizinate, monoammonium glycyrrhizinate, disodium 3-succinyloxydiglycyrrhizinate and the like can be mentioned. These production methods are known and are all commercially available.

Any one of these glycyrrhetinic acids and glycyrrhizic acids may be added to the cosmetic for hair of the present invention.
The seeds can be blended alone or in combination of two or more.

In the hair cosmetic composition of the present invention, the glycyrrhetinic acids and / or glycyrrhizic acids are preferably incorporated in an amount of 0.001 to 5.0% by weight based on the total weight of the hair cosmetic composition. 0.01-2.0% by weight
It is particularly preferred to be blended in the range of This amount is
If the amount is less than 0.001% by weight based on the total cosmetic amount for the hair, a sufficient anti-inflammatory effect is not exhibited, which is not preferable.
If the content is more than 0% by weight, there is a possibility that problems occur from the aspect of safety, such as inconvenience of the formulation, and furthermore, skin irritation and the like may occur.

The quacharalate extract, which is incorporated in the hair cosmetic composition of the present invention together with the above glycyrrhetinic acids and / or glycyrrhizic acids, is a quacharate (Cuachalalate, scientific name: Juliania adstringens) which grows especially in the Acapulco region on the Pacific coast of southern Mexico. ) Is an extract obtained from a plant called wound healing, burning,
It is already known to be effective for gingival health, digestive system cancer, hair loss, etc. (JP-A-4-181313),
Furthermore, they have been found to have a protease inhibitory action.

This quacharate extract is, for example,
Quacharate leaves, stems, flowers, bark, seeds, fruits, whole plants, etc. can be obtained by immersing in a solvent or refluxing with heating with a solvent, followed by filtration and concentration. In addition, the concentrate thus obtained can be further used in the hair cosmetics of the present invention by further subjecting the concentrate to purification, such as fractionation and chromatography, using a solvent. As the solvent, any solvent can be used as long as it is a solvent usually used for plant extraction. For example, alcohols such as methanol and ethanol, hydrous alcohols,
Organic solvents such as acetone and ethyl acetate can be used alone or in combination.

In the hair cosmetic composition of the present invention, the quacharate extract is used in an amount of 0.00% based on the total amount of the hair cosmetic composition.
It is preferably added in the range of 01 to 20.0% by weight, and particularly preferably in the range of 0.05 to 5.0% by weight.

If the amount of the quacharate extract is less than 0.0001% by weight based on the total weight of the cosmetic for hair, a sufficient anti-inflammatory effect cannot be obtained, which is not preferable. The tendency to cause inconvenience increases,
Further, it is not preferable from the point that skin irritation occurs.

Thus, by combining glycyrrhetinic acids and / or glycyrrhizic acids with the quacharate extract, it has excellent hair-growth effects, hair loss-preventing effects and dandruff and itching-preventing effects, and is safe. The cosmetic for hair of the present invention, which is excellent in properties, is provided.

In the hair cosmetic composition of the present invention, the medicinal component usually incorporated in the hair cosmetic composition is used in order to exert the general effect of the medicinal component. It is also possible to mix as long as the effect of the period is not impaired.

For example, blood flow enhancers such as assembly extract, vitamin E or derivatives thereof, nicotinic acid benzyl ester, cepharanthin, carpronium chloride, minoxidil; local stimulants such as cantharis extract, camphor, nonylate vanilamide; pyridoxine or its derivatives derivatives, sulfur, anti-seborrhoeic agents such as vitamin B _6; benzalkonium chloride, isopropyl methyl phenol, resorcinol, zinc pyrithione, No. 101 photosensitizer, photosensitizer 102
No. 3, salicylic acid, sodium salicylate, orthopyrox, hinokitiol, etc .; metabolic activators such as Photosensitizer 301, placenta extract, biotin; female hormones such as estradiol, estrone; anti-inflammatory agents other than glycyrrhetinic acids and glycyrrhizic acids; For example, diphenhydramine hydrochloride, purple root extract, menthol and the like; amino acids such as serine, methionine and tryptophan; vitamins such as vitamins A, B ₂ , B ₁₂ , D, pantothenic acid and derivatives thereof in the hair cosmetic of the present invention. Can also be blended.

Also, plant extracts, such as Altea extract, yoquinin extract, which are usually incorporated in hair cosmetics,
Peppermint extract, ginkgo biloba extract, capsicum extract, aloe extract, wolfberry extract, mugwort extract, rice extract, mankeishii extract, mannenwa extract, kossaiho extract, enishida extract, gentian extract, tanjin extract , Luffa extract, fennel extract, pine extract, kudin extract, touki extract, safflower extract, barberry extract, areca extract, eucalyptus extract, kagosou extract, mokusou extract, gossip extract, Psycho extract, tea extract, licorice extract, hop extract, chrysanthemum extract, senega extract, sesame extract, senkyu extract, cashew extract, cuckoo extract, Maikaika extract, saffron extract, rosemary An extract, a dirt extract, a mallow extract, and the like can be incorporated into the cosmetic for hair of the present invention.

Lactic acid or an alkyl ester thereof; organic acids such as succinic acid, malic acid and citric acid; protease inhibitors such as tranexamic acid; olive oil, squalane, liquid paraffin, isopropyl myristate,
Oils such as higher fatty acids and higher alcohols; polyhydric alcohols such as glycerin and propylene glycol; other surfactants, humectants, thickeners, antioxidants, ultraviolet absorbers, cooling agents, fragrances, pigments, ethanol, water, etc. Can be appropriately compounded within a range that does not impair the desired effect of the present invention.

The form of the cosmetic for hair of the present invention is not limited as long as it has a property applicable to the outer skin, such as a liquid, an emulsion, an ointment, a cream, a gel, and an aerosol. By blending the components and the like, it is possible to prepare the cosmetic for hair of the present invention in a desired product form. Also,
The cosmetic for hair of the present invention can be applied in various fields such as pharmaceuticals, quasi-drugs, and cosmetics.

The hair cosmetic composition of the present invention can be used for treating or preventing hair loss, dandruff, itch and the like, for example.
For example, it can be widely used for treatment and prevention of androgenetic alopecia, treatment and prevention of diffuse alopecia common to women, treatment of alopecia areata and the like. However, the objects shown here are examples, and the diseases applicable to the cosmetic for hair of the present invention are not limited to these objects.

The hair cosmetic composition of the present invention is generally administered by transdermal administration such as directly applying or spraying on the skin.
In the hair cosmetic of the present invention, the percutaneous absorption of the components is promoted by the combination of the above essential components). The dosage of the cosmetic for hair of the present invention should be appropriately determined according to individual differences such as age and the degree of hair loss and the form of the preparation, but the dosage for general adults is 1 kg body weight.
0.001-100 mg / day, preferably 0.1-1
0 mg / day, which can be administered in 2 to 4 times a day.

[0027]

EXAMPLES Hereinafter, the present invention will be described more specifically with reference to Examples and the like, but the technical scope of the present invention should not be limited by these Examples and the like. In addition, the compounding amount in these Examples and the like is a percentage by weight based on the entire system in which the component is compounded, unless otherwise specified. First, prior to disclosure of each embodiment, a test for examining the hair growth effect and the like of each embodiment will be described.

1. Hair- growth effect test In order to examine the hair-growth effect of the cosmetic for hair of the present invention, a tricogram test was performed. The subject was a male, and in the comparative example, 5
In this example, four persons were used. The sample application period was 4 months, and the sample was applied to the scalp twice a day twice a day. Immediately before application and after 4 months of application, 50 hairs were randomly removed from the crown for each subject,
The roots of the extracted hairs were observed under a microscope, and the root telogen rate (%) was calculated from the state of the roots. The rate of increase or decrease in the telogen rate before and after the sample application was determined based on the following criteria.

<Evaluation criteria> Remarkable effect (+): Hair root telogen rate decreased by 30% or more Weak effect (±): Hair root telogen rate decreased by 10% or more and less than 30% No effect (-): Hair root quiescence The period rate is reduced by less than 10%.
Is valid when the value exceeds the limit, and invalid for the others.

2. Hair loss prevention effect test The hair loss prevention effect was determined by the change in the number of hair washes before and after use of the sample. The subjects were male, eight in the comparative example, and four in the example. The test period was six months, the first two months were a period during which no sample was applied, and the last four months were a period during which the sample was applied. During the sample application period, apply the sample twice a day,
Each time 2-4 mL of sample was applied to the scalp. During the test period, the hair was washed every other day to collect the extracted hairs, and the number of hairs was counted for one week.

The number of hair removals during each period is shown in two months without application of the sample (no application period), data on the number of hair removals eight times in total, the last two months of the sample application period (application period), The data on the total number of hair removals for eight times are summarized for each period and displayed as the number of hair removals per time in the form of average value ± standard deviation.

The effect was determined from the difference between the average values in each period as follows. <Judgment criteria> ++: The number of removed hairs decreased by 70 or more, and a remarkable effect was recognized. +: The number of removed hairs decreased by 40 or more, and a considerable effect was recognized. ±: The number of removed hairs decreased by 10 or more. The effect was slightly recognized. −: The number of hair loss was less than 10 hairs, and the hair loss was ineffective.
Is valid when the value exceeds the limit, and invalid for the others.

3. Test for dandruff and itching-preventing effect The dandruff-preventing effect was compared with the change in the amount of protein in dandruff before and after sample application, and the itch-preventing effect was compared depending on the degree of itch after the sample application. The test subjects were particularly men who complained of dandruff and itching, and there were four subjects in each group in Comparative Examples and Examples. The sample was applied for a period of 3 months, during which time the hair was washed once a day with the same shampoo containing no drug, and the sample was applied for 1 month.
Twice a day, 2 to 4 mL was applied to the scalp at a time. Immediately before the application of the sample and after 3 months of application, the head dandruff was collected from the test subject with a suction device before shampooing, and the amount of protein (dandruff) in the dandruff was measured. The anti-dandruff effect of each sample was compared based on the increase / decrease of the average dandruff amount before and after sample application, and judged based on the following criteria. After the sample was applied for three months, the scalp of each subject was examined for itch, and the degree of itch was represented by the following score.

<Criteria for Antidandruff Effect> Remarkable effect (+): average dandruff decreased by 40% or more Weak effect (±): average dandruff decreased by 2% or more and less than 40% No effect (-): Average dandruff less than 2%

<Itchy score> 3: Strong itching 2: Itching 1: Slight itching 0: No itching

Examples 1 to 6 and Comparative Examples 1 to 3 Lotions of the components shown in Table 1 (Comparative Examples 1 to 3 and Examples 1 to 6) were prepared in accordance with the production method described later. The test was performed.

[0037]

[Table 1]

<Preparation method> Each of the drugs (quacharate extract, dipotassium glycyrrhizinate,
(β-glycyrrhetinic acid, glycyrrhizic acid), propylene glycol, hydrogenated castor oil ethylene oxide (40 mol) adduct, succinic acid and fragrance were dissolved (ethanol phase). Next, the dye was added to purified water, dissolved, and added to the ethanol phase, followed by stirring to obtain a clear liquid lotion.

The results of the above tests are shown in Tables 2 and 3 (hair growth effect test), Tables 4 and 5 (hair loss prevention effect test) and Table 6 (dandruff and itch prevention effect test). Indicated.

[0040]

[Table 2]

[0041]

[Table 3]

[0042]

[Table 4]

[0043]

[Table 5]

[0044]

[Table 6]

As is evident from these results, the lotion containing at least one of the above-mentioned glycyrrhizic acids and glycyrrhetinic acid, and the quacharate extract, has a hair-growth effect, a hair loss-preventing effect and a dandruff effect. Although the anti-itch effect was remarkably observed, at least one of glycyrrhetinic acids and glycyrrhizic acids was observed.
The effect of the lotion of Comparative Example containing any one of the seed and the quacharate extract was remarkably inferior to the results of the above-described examples even if a considerable amount of these components was added.

That is, in the hair cosmetic composition of the present invention in which the above-mentioned glycyrrhetinic acids and / or glycyrrhizic acids are combined with a quatcharate extract, a synergistic hair-growth effect, an anti-hair loss effect, and an anti-dandruff and itching-inhibiting effect. Was remarkably recognized. This is because the desired effect can be obtained in the hair cosmetic of the present invention even with a small amount of the active ingredient, and is caused by blending a large amount of glycyrrhetinic acids and glycyrrhizic acids, the coating portion and This indicates that it has become possible to prevent unpleasant irritation and redness at the periphery.

Hereinafter, still another formulation example of the hair cosmetic composition of the present invention will be described. [Example 7] Lotion (Blending ingredients) Blending amount (% by weight) 95% ethanol 50.0 Quacharate extract 0.5 Monoammonium glycyrrhizinate 0.2 Glycerin 2.0 Hardened castor oil ethylene oxide (40 mol) adduct 0 .8 Malic acid qs Flavor and pigment qs Purified water balance

<Preparation Method> Quacharate extract, hydrogenated castor oil ethylene oxide (40 mol) adduct, and perfume were dissolved in 95% ethanol (ethanol phase). Next, monoammonium glycyrrhizinate, glycerin, malic acid and a dye were added to purified water, dissolved, and added to the ethanol phase, followed by stirring to obtain a clear liquid lotion.

When the above-described test was carried out on the cosmetic for hair of the present invention, a hair-growth effect, a hair loss-preventing effect and a dandruff and itching-preventing effect were remarkably recognized.

[Example 8] Lotion (Blending component) Blending amount (% by weight) 95% ethanol 60.0 Quacharate extract 3.0 β-Glycyrrhetinic acid 1.0 1,3-butylene glycol 5.0 Hardened castor oil Ethylene oxide (50 mol) adduct 1.0 Sodium lauryl sulfate 0.5 Lactic acid qs Sodium lactate qs Flavors and dyes qs Purified water balance

<Production method> A hydrogenated castor oil ethylene oxide (50 mol) adduct and a fragrance were dissolved in 95% ethanol, and purified water was added. Then, quara larate extract, β-glycyrrhetinic acid, 1,3-butylene glycol, Sodium lauryl sulfate, lactic acid, sodium lactate and coloring matter were added and dissolved by stirring to obtain a transparent liquid lotion.

When the above-mentioned test was carried out on the cosmetic for hair of the present invention, a hair-growth effect, a hair loss-preventing effect and a dandruff and itching-preventing effect were remarkably recognized.

Example 9 Emulsion Type Hair Cosmetic (Ingredients) Ingredient (% by weight) (1) Cetanol 1.6 (2) Stearic acid 1.0 (3) Palmitic acid 0.4 (4) Liquid lanolin 1.0 (5) Squalane 2.5 (6) Glyceryl monostearate 1.5 (7) POE sorbitan monostearate 0.5 (8) Quacharate extract 1.0 (9) Stearyl glycyrrhetinate 0.0. 1 (10) Dipropylene glycol 5.0 (11) Polyethylene glycol 400 1.0 (12) Triethanolamine 1.0 (13) Residual purified water

<Production Method> A mixture 1 was prepared by mixing the components (1) to (9). Separately, the components (10) to (13) were mixed to prepare a mixture 2. These mixtures 1 and 2 were separately heated and melted at 70 ° C., mixed and emulsified using an emulsifier, and then heat-exchanged and cooled to obtain a latex hair cosmetic.

When the above-described test was carried out on the cosmetic for hair of the present invention, a hair-growth effect, a hair loss-preventing effect, and a dandruff and itching-preventing effect were remarkably recognized.

[0056]

Industrial Applicability According to the present invention, there is provided a cosmetic for hair which has an excellent hair-growth effect, an effect of preventing hair loss, an effect of preventing dandruff and itching, and is also excellent in safety.

Claims (1)

[Claims] 1. A cosmetic for scalp and hair containing glycyrrhetinic acids and / or glycyrrhizic acids and quatcharate extract.