JPH11269042A - Cosmetic for scalp and hair - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a cosmetic for scalp hair having excellent hair tonic effect, depilation-preventing effect and dandruff and itching-preventing effect and excellent also in safety. SOLUTION: This cosmetic for scalp and hair comprises (1) at least one kind of antimicrobial agent (preferably selected from a group comprising benzalkonium chloride, isopropylmethylphenol, resolcine, zinc pyrithione, a light sensitive dye No.101, light sensitive dye No.201, salicylic acid, sodium salicylate, octopirox and hinokitiol) and (2) oleyldimethylamine oxide and/or isostearyldimethylamine oxide.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a scalp hair cosmetic (hereinafter referred to as "hair cosmetic"). More specifically, the present invention relates to a hair cosmetic which has an excellent hair-growing effect and an effect of preventing hair loss, an effect of preventing dandruff and itchiness of the scalp, and which is also excellent in safety. Used in the field of quasi-drugs or cosmetics.

[0002]

2. Description of the Related Art There are various types of hair cosmetics.
There are products for various scalp hair conditions. For example, products have been developed that can improve blood circulation in the scalp, prevent dandruff and itch on the scalp, and prevent hair loss. Various troubles on the scalp are increasing with the increase of social stress in today's aging society, and the demand for hair cosmetics corresponding to the trouble on the scalp is rapidly increasing. In general, causes of baldness and hair loss on the head include activation of androgens in organs such as the sebaceous glands above the hair follicles, insufficient supply of nutrients due to a decrease in blood flow to the hair papilla and hair follicles, and corneal epithelium. Excessive dandruff, excessive sebum secretion, production of lipid peroxide, stress, and the like due to malformation and the like. When dandruff becomes excessive,
It is decomposed by scalp bacteria and the like, and the decomposed product stimulates the scalp and may cause hair loss accompanied by itching and inflammation. In addition, in order to grow durable and beautiful hair, it is important to provide sufficient nutrition to the nipples and hair follicles. The decrease in blood flow to the dermal papilla and hair follicle
It causes nutritional deficiency and a decrease in the function of excreting waste products, and causes fine hair and thin hair.

[0003] Conventional hair cosmetics generally contain a substance having an action of removing or reducing factors considered to be causes of baldness, hair loss and the like as described above. For example, in order to improve blood circulation in the scalp, a blood circulation promoting agent such as assembly extract, vitamin E and its derivatives, acetylcholine derivatives, and cepharanthin is blended.
An anti-inflammatory agent such as purple root extract is combined to suppress inflammation of the scalp caused by excessive sebum secretion, etc., and a female hormone agent such as estradiol is combined to suppress androgen, to prevent dandruff and itching Contains antibacterial agents such as salicylic acid, and amino acids such as serine and methionine for supplementing hair follicles, vitamins, etc., and is used to prevent and treat baldness, hair loss and hair thinning. ing.

[0004]

However, it is difficult to obtain a sufficient effect even if only a small amount of these components is incorporated into cosmetics for hair. There was a strong tendency to be accompanied by a tingling sensation and redness, and the blending amount was naturally limited.

The problem to be solved by the present invention is to provide a hair cosmetic composition which has an excellent hair-growth effect, a hair loss-preventing effect, a scalp dandruff and itching-preventing effect, and is also excellent in safety. is there.

[0006]

Means for Solving the Problems The present inventor has made intensive studies to solve this problem. As a result,
A hair cosmetic composition having excellent hair-growth effect, hair loss prevention effect, scalp dandruff and itching prevention effect and excellent safety by being combined in combination with a specific amine oxide. And completed the present invention.

That is, the present invention provides a hair cosmetic containing 1) at least one antibacterial agent, and 2) oleyldimethylamine oxide and / or isostearyldimethylamine oxide.

The antibacterial agent is selected from the group consisting of benzalkonium chloride, isopropylmethylphenol, resorcin, zinc pyrithione, photosensitizer 101, photosensitizer 201, salicylic acid, sodium salicylate, octopirox and hinokitiol. In the case of an antibacterial agent, the intended effect can be exhibited particularly well. In addition, this antibacterial agent is used in an amount of 0.001 to 5.
When the content is 0% by weight, the intended effect can be particularly favorably exhibited.

[0009]

Embodiments of the present invention will be described below. The cosmetic for hair of the present invention is a cosmetic for hair that exhibits an intended effect by being combined with an antibacterial agent and oleyldimethylamine oxide and / or isostearyldimethylamine oxide.

[0010] The antibacterial agent which can be incorporated into the hair cosmetic composition of the present invention can kill or reduce bacteria existing in the part of the human body by applying it on the skin and keep the part clean. As long as it is possible and there is no safety problem as a component of the external preparation, there is no particular limitation, and its mechanism of action should not be questioned.

More specifically, benzalkonium chloride, isopropylmethylphenol, resorcin, zinc pyrithione, Photosensitizer No. 101, Photosensitizer No. 201, salicylic acid,
Salicylates, octopirox, hinokitiol,
Conventionally, an antibacterial agent such as triclosan, benzethonium chloride, chlorhexidine, phenol, or trichlorocarbanilide, which is blended as an antibacterial agent in hair cosmetics, can be appropriately selected. Among these antibacterial agents, in particular, benzalkonium chloride, isopropylmethylphenol, resorcin, zinc pyrithione, photosensitizer 101
, Photosensitizer No. 201, salicylic acid, sodium salicylate, octopirox or hinokitiol, and it is preferable to select one or more of them and blend them in the cosmetic for hair of the present invention.

In the hair cosmetic composition of the present invention, the antibacterial agent is preferably added in a range of 0.001 to 5.0% by weight based on the total weight of the hair cosmetic composition. When the amount of the antibacterial agent is less than 0.001% by weight based on the total amount of the cosmetic for hair, it is difficult to sufficiently exhibit the desired antibacterial effect, which is not preferable. In addition, the total amount of the cosmetic for hair is 5.
If the amount exceeds 0% by weight, not only the tendency to cause inconvenience in the formulation increases, but also an unpleasant irritating feeling on the scalp,
Problems may arise from the viewpoint of safety, which is not preferable.

The oleyl dimethylamine oxide and / or isostearyl dimethylamine oxide to be incorporated into the hair cosmetic composition of the present invention together with the above antibacterial agent is represented by the following formula:

Embedded image These dimethylamine oxides can be produced according to a generally known method for producing an amine oxide.

The amount of oleyldimethylamine oxide and / or isostearyldimethylamine oxide in the hair cosmetic of the present invention is preferably 0.0001% by weight to 20.0% by weight based on the total weight of the hair cosmetic. Particularly preferred is 0.05% by weight to 5.0% by weight.

[0015] If the amount is less than 0.0001% by weight based on the total weight of the hair cosmetic composition, a sufficient anti-inflammatory effect cannot be exhibited, and if the amount exceeds 20.0% by weight, the formulation is inconvenient. This is not preferred in that it tends to cause skin irritation and causes skin irritation.

Thus, by combining the antibacterial agent and the above-mentioned dimethylamine oxide in combination, it has an excellent hair-growth effect, a hair loss-preventing effect, a scalp dandruff and itching-preventing effect, and a safety effect. The present invention provides a hair cosmetic composition which is also excellent.

The cosmetic for hair of the present invention contains the medicinal component usually incorporated in the cosmetic for hair in order to exert the general effect of the medicinal component. It is also possible to mix as long as the effect of the period is not impaired.

For example, blood circulation promoters such as assembly extract, vitamin E or derivatives thereof, acetylcholine derivatives, cepharanthin, carpronium chloride; local stimulants such as pepper tincture, cantharis extract, and nonylate vanilamide; pyridoxine or derivatives thereof, sulfur,
Anti-seborrhoeic agents such as vitamin B _6; photosensitizer No. 301, placenta extract, metabolism activating agents such as biotin; lithospermi radix extract, glycyrrhetinic acid or derivatives thereof, anti-inflammatory agents such as menthol; estradiol, female Mormon estrone like;
Amino acids such as serine, methionine and tryptophan;
Vitamins such as vitamins A, B ₂ , B ₁₂ , D, pantothenic acid and derivatives thereof can also be incorporated into the cosmetic for hair of the present invention.

Also, plant extracts, such as Altea extract, yoquinin extract, which are usually incorporated in hair cosmetics,
Peppermint extract, ginkgo biloba extract, capsicum extract, aloe extract, wolfberry extract, mugwort extract, rice extract, mankeishii extract, mannenwa extract, kossaiho extract, enishida extract, gentian extract, tanjin extract , Luffa extract, fennel extract, pine extract, kudin extract, touki extract, safflower extract, barberry extract, areca extract, eucalyptus extract, kagosou extract, mokusou extract, gossip extract, Psycho extract, tea extract, licorice extract, hop extract, chrysanthemum extract, senega extract, sesame extract, senkyu extract, cashew extract, cuckoo extract, Maikaika extract, saffron extract, rosemary An extract, a dirt extract, a mallow extract, and the like can be incorporated into the cosmetic for hair of the present invention.

Organic acids such as lactic acid or its alkyl ester; citric acid; protease inhibitors such as tranexamic acid; olive oil, squalane, liquid paraffin, isopropyl myristate, higher fatty acids, higher alcohols and other oils; glycerin, propylene Polyhydric alcohols such as glycols; and other surfactants such as polyoxyethylene hydrogenated castor oil, humectants, thickeners, antioxidants, ultraviolet absorbers, fresheners, fragrances, dyes, ethanol, water, etc. It can be appropriately compounded within a range that does not impair the desired effect.

The form of the cosmetic for hair of the present invention is not limited as long as it can be applied to the outer skin, such as a liquid, an emulsion, an ointment, a cream, a gel, an aerosol, and the like. By blending the components and the like, it is possible to prepare the cosmetic for hair of the present invention in a desired product form. Also,
The cosmetic for hair of the present invention can be applied in various fields such as pharmaceuticals, quasi-drugs, and cosmetics.

The hair cosmetic composition of the present invention can be used for treating or preventing hair loss, dandruff, itch and the like, for example.
For example, it can be widely used for treatment and prevention of androgenetic alopecia, treatment and prevention of diffuse alopecia common to women, treatment of alopecia areata and the like. However, the objects shown here are examples, and the diseases applicable to the cosmetic for hair of the present invention are not limited to these objects.

The cosmetic for hair of the present invention is generally administered by transdermal administration such as directly applying or spraying on the skin (in addition,
In the hair cosmetic of the present invention, the percutaneous absorption of the components is promoted by the combination of the above essential components). The dosage of the cosmetic for hair of the present invention should be appropriately determined according to individual differences such as age and the degree of hair loss and the form of the preparation, but the dosage for general adults is 1 kg body weight.
0.001-100 mg / day, preferably 0.1-1
0 mg / day, which can be administered in 2 to 4 times a day.

[0024]

EXAMPLES Hereinafter, the present invention will be described more specifically with reference to Examples and the like, but the technical scope of the present invention should not be limited by these Examples and the like. First, prior to disclosure of each embodiment, a test for examining the hair growth effect and the like of each embodiment will be described.

1. Hair- growth effect test In order to examine the hair-growth effect of the cosmetic for hair of the present invention, a tricogram test was performed. The test subjects were male and 10 persons in each group of Comparative Example and Example. The test application period is four months,
The sample was applied to the scalp twice a day, 2 to 4 mL each time. Immediately before application and 3 months after application, subject 1
Fifty hairs were randomly removed from the crown for each name, the roots of the removed hairs were observed under a microscope, and the follicle resting period rate (%) was calculated from the state of the roots. The rate of increase or decrease in the telogen rate before and after the sample application was determined based on the following criteria.

<Judgment criteria> Remarkable effect: Hair root telogen rate reduced by 30% or more Effective: Hair root telogen rate reduced by 20% or more Weak effect: Hair root telogen rate reduced by 10% or more No effect: Hair root telogen Rate decreased by less than 10%.
% Is valid, and the others are invalid.

2. Hair loss prevention effect test The hair loss prevention effect was determined by the change in the number of hair washes before and after use of the sample. The test subjects were male, and the male and female subjects in the comparative example and the example were each 10 persons. The test period was six months, the first two months were a period during which no sample was applied, and the last four months were a period during which the sample was applied. During the sample application period, apply the sample 2 times a day.
Each time, 2 to 4 mL of the sample was applied to the scalp. During the test period, the hair was washed every other day to collect the extracted hairs, and the number of hairs was counted for one week.

The display of the number of hair removals in each period is based on the data of the number of hair removals eight times in total during the two months when the sample is not applied and the data of the number of hair removals eight times in the latter two months of the period in which the sample is applied. The results were summarized for each period and displayed as the number of hair removals per time in the form of average value ± standard deviation.

The effect was judged as follows from the difference between the average values in each period. <Judgment criteria> ++: The number of removed hairs decreased by 70 or more, and a remarkable effect was recognized. +: The number of removed hairs decreased by 40 or more, and a considerable effect was recognized. ±: The number of removed hairs decreased by 10 or more. The effect was slightly recognized. −: The number of hair loss was less than 10 hairs, and the hair loss was ineffective.
Is valid when the value exceeds the limit, and invalid for the others.

3. Test of dandruff and itching prevention effect The dandruff and itch prevention effect were examined after each test period for each subject's scalp dandruff and itch, and the degree of dandruff and itching were compared. Subjects were males who complained of dandruff and itching, and each group of Comparative Examples and Examples
10 people. The sample was applied for a period of three months, during which time the hair was washed once a day with the same shampoo containing no drug, and the sample was applied twice a day to the scalp twice a day. After the test, the degree of dandruff and itching of each subject was represented by the following scores.

<Danmark score> 3: Significantly dandruff 2: Many dandruff 1: Slightly dandruff 0: Almost no dandruff

<Itching score> 3: Strong itching 2: Itching 1: Slight itching 0: No itching

Examples 1 to 12 and Comparative Examples 1 to 12
Lotions of the components shown in the table (Examples 1 to 12 and Comparative Examples 1 to 12) were prepared according to the production methods described below, and the above tests were performed.

[0034]

[Table 1]

<Production method> Various drugs such as oleyl dimethylamine oxide and isostearyl dimethylamine oxide (benzalkonium chloride, isopropylmethylphenol, resorcinol, zinc pyrithione, photosensitive element 101, photosensitive element 201) in 95% ethanol , Salicylic acid, sodium salicylate, octopirox and hinokitiol), glycerin, hydrogenated castor oil ethylene oxide (60 mol) adduct, succinic acid and fragrance were dissolved (ethanol phase). Next, a dye was added to purified water, dissolved, and added to the ethanol phase, followed by stirring to obtain a clear liquid lotion. The results of the above tests are shown in Table 2 (hair growth effect test), Table 3 (hair loss prevention effect test), and Table 4 (dandruff and itching prevention effect test).

[0036]

[Table 2]

[0037]

[Table 3]

[0038]

[Table 4]

As is clear from these results, benzalkonium chloride, isopropylmethylphenol, resorcin, zinc pyrithione, photosensitizer No. 101, photosensitizer 2
No. 01, one or two selected from salicylic acid, sodium salicylate, octopirox and hinokitiol
In the lotions of the Examples in which at least one kind of antibacterial agent and the above-mentioned dimethylamine oxide were blended, the effect of raising hair, preventing hair loss and preventing dandruff and itch were remarkably recognized. The effect of the comparative example containing only one of the oxides was remarkably inferior to the result of the above example even if a considerable amount of these components was incorporated.

That is, in the hair cosmetic composition of the present invention in which the above-mentioned antibacterial agent and the above-mentioned dimethylamine oxide are combined in combination, a synergistic hair-growing effect, a hair loss-preventing effect, and a dandruff and itching-preventing effect are remarkably observed. It became clear. This is because the desired effect can be obtained in the hair cosmetic of the present invention even with a small amount of the active ingredient, and the application part and its surroundings caused by blending these components in a large amount can be obtained. This indicates that it has become possible to prevent unpleasant irritation and redness of the part.

Hereinafter, still another formulation example of the hair cosmetic composition of the present invention will be described. [Example 13] Lotion (Blending component) Blending amount (% by weight) 95% ethanol 65.0 Oleyldimethylamine oxide 2.0 Isopropylmethylphenol 0.1 Propylene glycol 3.0 Hardened castor oil ethylene oxide (40 mol) adduct 0.5 Malic acid qs Perfume and pigment qs Purified water balance

<Production Method> Oleyldimethylamine oxide, isopropylmethylphenol, propylene glycol, an adduct of hydrogenated castor oil ethylene oxide (40 mol), malic acid and a fragrance were dissolved in 95% ethanol (ethanol phase). Next, after dissolving the dye in purified water, the dye was added to the ethanol phase and stirred and dissolved to obtain a clear liquid lotion.

When the above-mentioned test was carried out on the cosmetic for hair of the present invention, a hair-growth effect, a hair loss-preventing effect and a dandruff and itching-preventing effect were remarkably recognized.

Example 14 Lotion (Blending Components) Blending Amount (% by Weight) 95% Ethanol 60.0 Isostearyldimethylamine Oxide 5.0 Ortopirox 0.5 Hinokitiol 0.5 Salicylic Acid 0.2 Dipropylene Glycol 4.0 Hardened castor oil ethylene oxide (50 mol) adduct 0.5 Malic acid qs Perfume and pigment qs Purified water balance

<Production method> Isostearyl dimethylamine oxide, orthopyrox, hinokitiol, salicylic acid, dipropylene glycol, hydrogenated castor oil ethylene oxide (50 mol) adduct, malic acid, and a fragrance were dissolved in 95% ethanol (ethanol). phase). Next, after dissolving the dye in purified water, this was added to the ethanol phase and stirred and dissolved to obtain a transparent liquid lotion.

When the above-mentioned test was carried out on the cosmetic for hair of the present invention, a hair-growing effect, a hair loss-preventing effect, and a dandruff and itching-preventing effect were remarkably recognized.

Example 15 Lotion (Blending Components) Blending Amount (% by Weight) 95% Ethanol 50.0 Oleyldimethylamine Oxide 1.0 Isostearyldimethylamine Oxide 0.1 Benzalkonium Chloride 0.3 Photosensitive Element 101 No. 0.2 Sodium salicylate 1.0 1,3-butylene glycol 2.0 Hydrogenated castor oil Ethylene oxide (60 mol) adduct 0.7 Malic acid Appropriate amount Flavor and pigment Appropriate amount Purified water balance

<Production method> In 95% ethanol, oleyl dimethylamine oxide, isostearyl dimethylamine oxide, benzalkonium chloride, photosensitizer No. 101, sodium salicylate, 1,3-butylene glycol, hydrogenated castor oil ethylene oxide (60 mol) The adduct, malic acid and flavor were dissolved (ethanol phase). Next, after dissolving the dye in purified water, this was added to the ethanol phase and stirred and dissolved to obtain a transparent liquid lotion.

The above-mentioned test was carried out on the cosmetic for hair of the present invention. As a result, a hair-growth effect, a hair loss-preventing effect, and a dandruff and itching-preventing effect were remarkably recognized.

Example 16 Emulsion (Blending Components) Blending Amount (% by Weight) (1) Cetanol 1.5 (2) Stearic Acid 1.2 (3) Palmitic Acid 0.6 (4) Liquid Lanolin 1.0 (5) Squalane 2.0 (6) Glyceryl monostearate 1.6 (7) POE Sorbitan monostearate 0.5 (8) Isostearyl dimethylamine oxide 2.0 (9) Oleyl dimethylamine oxide 1.0 ( 10) Zinc pyrithione 0.01 (11) Resorcinol 0.3 (12) Polyethylene glycol 5.0 (13) Triethanolamine 1.0 (14) Purified water balance

<Production method> A mixture was prepared by mixing the components (1) to (11). Separately, a mixture was prepared by mixing the components (12) to (14). These mixtures were separately heated to 70 ° C. and dissolved, and then both were mixed.
After this was mixed and emulsified by an emulsifier, heat exchange cooling was performed to obtain an emulsion.

When the above-described test was carried out on the cosmetic for hair of the present invention, a hair-growth effect, a hair loss-preventing effect, and a dandruff and itching-preventing effect were remarkably recognized.

[0053]

Industrial Applicability According to the present invention, there is provided a hair cosmetic composition having an excellent hair-growth effect, an effect of preventing hair loss, an effect of preventing dandruff and itching of the scalp, and also having excellent safety.

Claims (3)

[Claims] 1. A cosmetic composition for scalp hair containing 1) at least one antibacterial agent and 2) oleyldimethylamine oxide and / or isostearyldimethylamine oxide. 2. An antibacterial agent comprising benzalkonium chloride, isopropylmethylphenol, resorcin, zinc pyrithione, photosensitizer 101, photosensitizer 201, salicylic acid,
The scalp hair cosmetic according to claim 1, which is an antibacterial agent selected from the group consisting of sodium salicylate, octopirox and hinokitiol. 3. The scalp hair cosmetic according to claim 1, wherein the antibacterial agent is contained in an amount of 0.001 to 5.0% by weight based on the whole scalp hair cosmetic.