JPH11322545A - Cosmetic for scalp and hair - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject highly safe cosmetic having excellent hair growing effect, depilation preventive effect and dandruff/itch preventive effect by including a specific amine oxide and a hair follicle stimulant. SOLUTION: This cosmetic for scalp and the hair is obtained by including (A) pref. 0.0001-20 wt.% of an amine oxide of the formula (R<1> is a 10-36C alkyl or alkenyl) (pref. N,N-dimethyl-2-decyltetradecylamine oxide, oleyldimethylamine oxide or the like) and (B) pref. 0.001-5 wt.% of a hair follicle stimulant (pref. nicotinamide, vitamin B6 , or the like). This cosmetic can be formulated, as necessary, with an oily ingredient, surfactant, antioxidant, etc., as well. This cosmetic is usable in the formulation of a liquid, emulsion, ointment, cream, gel or aerosol, and in the form of a tonic, scalp treatment, etc.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a cosmetic for scalp hair. More specifically, the present invention relates to a scalp hair cosmetic composition having an excellent hair-growing effect, an anti-hair loss effect, and a dandruff / itch prevention effect, and having excellent safety.

[0002]

2. Description of the Related Art In a modern society called an aging society and a stressed society, various troubles on the scalp and hair, such as baldness of the head, hair loss, thinning of hair, dandruff and itching of the scalp, are increasing. The demand for scalp and hair cosmetics corresponding to the demand is rapidly increasing. For this reason, research and development of various products corresponding to each trouble are being performed.

The scalp and hair are structurally scalp (skin)
The epidermis is recessed toward the dermis to form a lumen and form a hair follicle,
Sebaceous glands are connected above the hair follicle. The hair is located inside the hair follicle, and is divided into a hair shaft, which is a part protruding from the surface of the skin (scalp), and a hair root that penetrates into the skin. Hair grows and falls repeatedly according to a so-called “hair cycle” consisting of a anagen, a catagen and a telogen. Hair follicles are said to be involved in the anagen phase of this hair cycle.

The causes of head baldness, hair loss, thinning of hair, dandruff and itching of the scalp, etc. are caused by activation of androgens in the sebaceous glands of hair roots, excessive secretion of sebum, production of lipid peroxide, and hair follicles. Blood flow and stress. In addition, when growing hair that is durable and beautiful, if hair follicles cannot be adequately nourished, fine hair and thin hair may be caused. A decrease in blood flow to the hair follicles leads to nutritional deficiencies and a decrease in waste excretion function.

[0005] From such a viewpoint, it is necessary to improve the turnover of the stratum corneum and excessive secretion of sebum in the scalp, at least to improve the blood flow function in the scalp and to solve the scalp and hair troubles. It is considered indispensable.

[0006] Conventional head hair cosmetics generally contain a substance having an action of removing or reducing factors considered to be the cause of baldness and hair loss. For example, vitamins such as vitamin B and vitamin E, amino acids such as serine and methionine, vasodilators such as assembly extract and acetylcholine derivatives, anti-inflammatory agents such as shiban extract, hormonal agents for women such as estradiol, cepharanthin, etc. Are used for the prevention and treatment of baldness, hair loss and thinning of hair.

[0007]

However, in a hair cosmetic containing these components, a certain amount or more must be added in order to obtain a sufficient effect, while a large amount of these components is added. Then, there is a tendency that an unpleasant irritant feeling or redness is accompanied in and around the used part, and the amount of the compound is naturally limited. Therefore, it has been difficult to obtain a sufficiently satisfactory effect in the prevention and prevention of baldness, hair loss and hair thinning while satisfying usability and safety.

The present invention has been made in view of the above circumstances, and provides a scalp hair cosmetic composition having an excellent hair loss preventing effect, a hair nourishing effect, a scalp dandruff / itch prevention effect, and excellent safety. The purpose is to do.

[0009]

Means for Solving the Problems The present inventors have made intensive studies to solve the above-mentioned problems, and as a result, by combining specific amine oxides and a hair follicle activator, excellent hair removal is achieved. The present inventors have found that a cosmetic for scalp hair which has an effect of preventing hair growth and hair growth, an effect of preventing dandruff and itchiness of the scalp, and which is excellent in safety is provided, and has completed the present invention.

That is, the present invention provides a compound represented by the following general formula (I):

[0011]

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The present invention relates to a cosmetic for scalp hair containing an amine oxide represented by the formula (wherein R ¹ represents an alkyl or alkenyl group having 10 to 36 carbon atoms) and a hair follicle activator.

[0013]

BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, the present invention is described in detail.

The amine oxides used in the present invention include:
It is represented by the general formula (I). In the formula, R ¹ represents an alkyl group or an alkenyl group having 10 to 36 carbon atoms,
The number of carbon atoms is preferably 12 to 24. As such amine oxides, specifically, one or more selected from N, N-dimethyl-2-decyltetradecylamine oxide, oleyldimethylamine oxide, and isostearyldimethylamine oxide are preferably used. Can be Among them, oleyldimethylamine oxide is particularly preferably used. Further, one or more of oleyldimethylamine oxide and isostearyldimethylamine oxide are also preferably used.

The amount of the above-mentioned amine oxides is preferably 0.0001 to 20% by weight, more preferably 0.05 to 5% by weight, based on the total amount of the cosmetic for scalp and hair. If the content is less than 0.0001% by weight, sufficient hair loss prevention, hair restoration effect, scalp dampness,
It is difficult to obtain an anti-itch effect, while 20% by weight
If it exceeds, unpleasant sticky feeling and irritation tend to be imparted to the scalp during use, which is not preferable.

The hair follicle activator used in the present invention includes
The substance is not particularly limited as long as it can activate the hair follicle, but in particular, nicotinamide, vitamin B ₆ and its derivatives (eg, pyridoxine dioctanoate),
Biotin, pantothenic acid and derivatives thereof (eg, pantothenyl ethyl ether, etc.), cepharanthin, mononitroguaiacol, sodium mononitroguaiacol, 6-benzylaminopurine, diisopropylamine dichloroacetic acid, hinokitiol, pentadecanoic acid monoglyceride and the like are preferably used. One or more hair follicle activators are used.

The amount of the hair follicle activator is preferably 0.001 to 5% by weight, more preferably 0.1 to 5% by weight, based on the total amount of the cosmetic for scalp and hair.
0.01 to 2% by weight. If it is less than 0.001% by weight, it is difficult to obtain sufficient hair loss prevention, hair-growth effects and scalp dandruff / itch prevention effects, while if it exceeds 5% by weight, unpleasant irritation tends to occur on the preparation or on the scalp. This is not preferred.

The cosmetic for scalp hair of the present invention may further comprise, in addition to the above essential components, an oily component, a surfactant, an antioxidant, and an ultraviolet absorber, if necessary, as long as the effects of the present invention are not impaired. Ingredients generally used in scalp and hair cosmetics, such as humectants, fragrances, dyes, pigments, pigments, preservatives, vitamins, hormones, deodorants, pH adjusters, and fixing agents may be added. .

The cosmetic for scalp and hair of the present invention may be in any form that can be applied externally, such as a liquid, an emulsion, an ointment, a cream, a gel, or an aerosol, and may be in the form of a tonic, scalp treatment or the like. Used.

[0020]

Next, the present invention will be described in more detail with reference to examples, but the present invention is not limited to these examples. Unless otherwise specified, the amount is shown in% by weight.

First, test methods and evaluation methods of a hair growth effect test, a hair loss prevention effect test, and a dandruff / itch prevention effect test used in this example will be described.

[Test of Hair Restoring Effect] To examine the effect of the hair restoring effect of the present invention, a tricogram test was carried out. The test subjects were male, and each of the comparative example and the example was 10 persons in each group. The test period (sample application period) was 4 months, and during the period, 2 to 4 ml of the sample was applied to the scalp twice a day. Immediately before the start of sample application and after the end of the sample application period, 50 hairs were randomly removed from the crown of each subject, and the roots of the removed hairs were observed under a microscope. (%) Was calculated. The ratio of increase or decrease in the follicle rest period rate (%) before and after the sample application period was determined based on the following criteria. (Judgment criteria) Remarkable effect: Hair root telogen rate decreased by 30% or more Effective: Hair root telogen rate decreased by 20% or more Weak effect: Hair root telogen rate decreased by 10% or more No effect: Hair root telogen rate: 10 Less than or less than (evaluation of hair growth effect) "Effective" in the above criteria
The case where the percentage of the subjects who made the above judgment was 50% or more was regarded as valid, and the other cases were regarded as invalid.

[Test for the effect of preventing hair loss] The change was measured by the change in the number of hair loss due to hair washing before and after using the sample. The test subjects were male, and each of the comparative example and the example was 10 persons in each group. The test period was six months, the first two months were the period of no sample application, and the last four months were the sample application period. During the sample application period, 2 to 4 ml of the sample was applied to the scalp twice a day. During the test period, hair was washed every other day and hair loss was collected.
The number of end hairs was counted for a week. The evaluation of the number of hair loss was performed using the number of hair loss per hair washing during the sample application period, and the average value of the last week in the first half and the average value of the last week in the second half were implemented. (Judgment criteria) ++: The number of hair loss was reduced by 70 or more and a remarkable effect was recognized. +: The number of hair loss was reduced by 40 or more and a considerable effect was recognized. ±: The number of hair loss was reduced by 10 or more. A slight effect was observed.-: The number of hair loss was less than 10 or the number of hair loss increased and no effect was observed. (Evaluation of hair loss prevention effect) Percentage of subjects who judged "+" or more in the above criteria Is 50% or more, the result is valid, and the other cases are invalid.

[Test for dandruff / itch prevention effect]
For men who complain of itching, dandruff and itch after the test (sample application) were examined for 10 subjects in each group of Comparative Examples and Examples, and evaluated by the amount of protein in the dandruff and the degree of itch. The sample application period was 3 months. During this period, the hair was washed once a day with a shampoo containing no drug, and the sample was applied twice a day to the scalp twice a day.

At the end of the test, head dandruff was collected from the test subject with a suction device before washing the hair, and the amount of protein in the dandruff was measured.

Each subject was asked to express the degree of scalp itch by the following score. (Itching score) 3: Strong itching 2: Itching 1: Slight itching 0: No itching

(Comparative Examples 1 to 12, Examples 1 to 12) In the compositions shown in Tables 1 to 4 below, 95% ethanol was added to N,
N-dimethyl-2-decyltetradecylamine oxide was dissolved, and each hair follicle activator, dipropylene glycol, adduct of hydrogenated castor oil ethylene oxide (40 mol), succinic acid, and a fragrance were dissolved (ethanol part). Separately, the dye was added to purified water and dissolved (aqueous part). This water part was added to the ethanol part and stirred to obtain a clear liquid lotion.

[0028]

[Table 1]

[0029]

[Table 2]

[0030]

[Table 3]

[0031]

[Table 4]

Using the samples of Comparative Examples 1 to 12 and Examples 1 to 12, the above-described hair growth effect test, hair loss prevention effect test,
A dandruff / itch prevention effect test was performed and evaluated.
The results are shown in Tables 5, 6, and 7, respectively.

[0033]

[Table 5]

[0034]

[Table 6]

[0035]

[Table 7]

As is evident from Tables 5, 6, and 7, the present invention was excellent in hair-growth effect, hair loss prevention effect, and dandruff / itch prevention effect.

(Example 13) Lotion (combination component) (% by weight) 95% ethanol 55.0 N, N-dimethyl-2-decyltetradecylamine oxide 5.0 Nicotinamide 0.5 Hinokitiol 0.2 1,3-butylene glycol 1.5 POE hydrogenated castor oil (60 mole addition) 1.0 succinic acid qs perfume qs Dye qs Purified water balance (Production method) N, N-dimethyl-2 in 95% ethanol
-Decyltetradecylamine oxide, further dissolving nicotinamide, hinokitiol, 1,3-butylene glycol, POE hydrogenated castor oil (60 mol addition),
The fragrance was dissolved (ethanol part). Separately, succinic acid and a dye were dissolved in purified water (aqueous part). This water part was added to the ethanol part and stirred to obtain a clear liquid lotion.

Example 14 Lotion (combined component) (% by weight) 95% ethanol 75.0 N, N-dimethyl-2-decyltetradecylamine oxide 0.03 pantothenyl ethyl ether 5.0 cepharanthin 0.0 05 Dipropylene glycol 1.0 POE (24 mol) / POP (13 mol) Decyl tetradecyl ether 0.5 Lactic acid Suitable amount Sodium lactate Suitable amount Fragrance proper amount Pigment proper amount Purified water residue (Production method) 95% ethanol N, N-dimethyl-2
-Decyltetradecylamine oxide, and further dissolve pantothenyl ethyl ether, cepharanthin, dipropylene glycol, POE (24 mol) .POP
(13 mol) decyltetradecyl ether and a fragrance were dissolved (ethanol part). On the other hand, separately from this, lactic acid, sodium lactate, and a pigment were dissolved in purified water (water part).
This water part was added to the ethanol part and stirred to obtain a clear liquid lotion.

Example 15 Lotion (combined component) (% by weight) 95% ethanol 60.0 N, N-dimethyl-2-decyltetradecylamine oxide 20.0 mononitroguaiacol sodium 1.0 vitamin B ₆ 0.5 6-Aminobenzylpurine 0.5 Diisopropylamine dichloroacetic acid 0.05 Polyethylene glycol (400) 0.5 POE hydrogenated castor oil (20 mol) 1.0 Phosphoric acid qs Flavor qs Dye qs Purified water Rest (Production method) N, N-dimethyl-2 in 95% ethanol
- dissolved decyltetradecyl amine oxide further mononitroguayacol sodium, vitamin B _6,
6-aminobenzyl purine, diisopropylamine dichloroacetic acid, polyethylene glycol (400), POE
Hardened castor oil (20 mol) and a fragrance were dissolved (ethanol part). On the other hand, separately from this, phosphoric acid and a dye were dissolved in purified water (aqueous part). This water part was added to the ethanol part and stirred to obtain a clear liquid lotion.

Examples 13 to 15 were excellent in the effect of raising hair and preventing hair loss, and were also excellent in preventing dandruff and itch.

(Comparative Examples 13 to 23, Examples 16 to 27)
In the compositions shown in Tables 8 to 11 below, one or more of oleyldimethylamine oxide and isostearyldimethylamine oxide are dissolved in 95% ethanol,
Further, each hair follicle activator, dipropylene glycol, hydrogenated castor oil ethylene oxide (50 mol) adduct, malic acid, and fragrance were dissolved (ethanol part). Separately, the dye was added to purified water and dissolved (aqueous part). This water part was added to the ethanol part and stirred to obtain a clear liquid lotion.

[0042]

[Table 8]

[0043]

[Table 9]

[0044]

[Table 10]

[0045]

[Table 11]

Comparative Examples 13 to 23 and Examples 16 to 27
Using the above sample, the above-described hair growth effect test, hair loss prevention effect test, and dandruff / itch prevention effect test were performed and evaluated. The results are shown in Tables 12, 13, and 14, respectively.

[0047]

[Table 12]

[0048]

[Table 13]

[0049]

[Table 14]

As is clear from Tables 12, 13, and 14, the present invention is excellent in hair-growth effect and hair loss-preventing effect.
Excellent anti-itch effect.

Example 28: Lotion (combination component) (% by weight) 95% ethanol 55.0 oleyldimethylamine oxide 2.0 nicotinamide 0.1 glycerin 1.0 hydrogenated castor oil ethylene oxide (40 mol) ) Adduct 0.5 malic acid qs perfume qs pigments qs purified water balance (Production method) 95% ethanol in oleyldimethylamine oxide, nicotinamide, glycerin, hydrogenated castor oil ethylene oxide (40 mol) adduct, Malic acid and flavor were dissolved (ethanol part). Separately, the dye was dissolved in purified water (Aqueous part). This water part was added to the ethanol part and stirred to obtain a clear liquid lotion.

(Example 29: lotion) (combination component) (% by weight) 95% ethanol 65.0 isostearyl dimethylamine oxide 3.0 pantothenyl ethyl ether 5.0 cepharanthin 0.01 biotin 0.2 di Propylene glycol 5.0 Hardened castor oil ethylene oxide (50 mol) adduct 0.5 Malic acid qs Flavor qs Dye qs Purified water balance (Production method) Isostearyl dimethylamine oxide, pantotenyl ethyl ether in 95% ethanol , Cepharanthin, biotin, dipropylene glycol,
The hydrogenated castor oil ethylene oxide (50 mol) adduct, malic acid and flavor were dissolved (ethanol part). Separately, the dye was dissolved in purified water (Aqueous part). This water part was added to the ethanol part and stirred to obtain a clear liquid lotion.

Example 30: lotion (combination component) (% by weight) 95% ethanol 50.0 oleyldimethylamine oxide 2.0 isostearyldimethylamine oxide 2.0 mononitroguaiacol 0.1 6-benzyl Aminopurine 0.001 Diisopropylamine dichloroacetic acid 0.5 1,3 butylene glycol 2.0 Hardened castor oil ethylene oxide (60 mol) adduct 0.7 Succinic acid qs Flavor qs Dye qs Purified water Method) Oleyl dimethyl amine oxide, isostearyl dimethyl amine oxide in 95% ethanol,
Mononitroguaiacol, 6-benzylaminopurine,
Diisopropylamine dichloroacetic acid, 1,3 butylene glycol, hydrogenated castor oil ethylene oxide (60 mol)
The adduct, succinic acid and flavor were dissolved (ethanol part). Separately, the dye was dissolved in purified water (Aqueous part). This water part was added to the ethanol part and stirred to obtain a clear liquid lotion.

(Example 31: Emulsion) (Combined component) (% by weight) (1) Cetanol 1.6 (2) Stearic acid 1.3 (3) Palmitic acid 0.5 (4) Liquid lanolin 1. 0 (5) squalane 2.0 (6) glyceryl monostearate 1.7 (7) POE sorbitan monostearate 0.5 (8) isostearyl dimethylamine oxide 0.5 (9) oleyl dimethylamine oxide 0.5 (10) Pentadecanoic acid monoglyceride 1.0 (11) Mononitroguaiacol sodium 0.3 (12) Polyethylene glycol 5.0 (13) Triethanolamine 1.0 (14) Purified water balance (Production method) (1) To (11) were mixed to obtain a mixture. On the other hand, apart from this, (12) to (14)
Were mixed to obtain a mixture. Each mixture was separately heated to 70 ° C., dissolved, mixed and emulsified by an emulsifier, and then cooled by heat exchange to obtain an emulsion.

[0055]

Industrial Applicability The scalp hair cosmetic composition of the present invention has an excellent hair-growth effect and an effect of preventing hair loss, and also has an excellent effect of preventing dandruff and itch.

Claims (7)

[Claims] 1. A compound represented by the following general formula (I) (Wherein R ¹ represents an alkyl or alkenyl group having 10 to 36 carbon atoms) and a hair follicle activator containing a hair follicle activator. 2. An amine oxide comprising N, N-dimethyl-
The scalp hair cosmetic according to claim 1, wherein the cosmetic is one or more selected from 2-decyltetradecylamine oxide, oleyldimethylamine oxide, and isostearyldimethylamine oxide. 3. The method according to claim 1, wherein the amine oxide is N, N-dimethyl-
The scalp hair cosmetic according to claim 2, which is 2-decyltetradecylamine oxide. 4. The scalp hair cosmetic according to claim 2, wherein the amine oxide is at least one of oleyldimethylamine oxide and isostearyldimethylamine oxide. 5. The hair follicle activators nicotinamide, vitamin of B ₆ and derivatives thereof, biotin, pantothenic acid and its derivatives, cepharanthine, mononitroguayacol, mononitroguayacol sodium, 6-benzylaminopurine, diisopropylamine dichlorprop The scalp hair cosmetic according to any one of claims 1 to 4, wherein the cosmetic is at least one selected from acetic acid, hinokitiol, and pentadecanoic acid monoglyceride. 6. An amine oxide is used in an amount of 0.0001 to 20.
The scalp hair cosmetic according to any one of claims 1 to 5, wherein the cosmetic is contained by weight. 7. The cosmetic for scalp hair according to claim 1, comprising 0.001 to 5% by weight of a hair follicle activator.