JPH1017440A - Hair growing and restoring agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a hair growing and restoring agent having excellent hair growing activities such as depilation-proofing and trichogenous effects, containing, as active ingredients, the respective extracts from Caryophilli flos and Houttuyniae herba. SOLUTION: This hair growing and restoring agent contains, an active ingredients, an extract derived from the buds of Syzygium aromaticum Merrill et perry and another extract derived from the whole grass of Houttuynia cordata of Saururaceae family. These extracts can also be used in combination with an extract from cranesbill, and a cell activator and/or blood circulation promoter. The amounts of these extracts to be formulated are 0.001-10wt.% on a dry basis in the final agent. Each of these extracts is obtained by subjecting the dried finely chopped crude drug of an appropriate size to extraction using a solvent (e.g. water, ethanol) at room temperature of higher temperature followed by purification. The agent can be prepared into hair tonic, hair lotion, hair cream, aerosol, ointment, etc., which is used through application to the scalp at an appropriate amount once to several times a day. This agent is safe over a long period.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD [0001] The present invention relates to a hair-growing / hair-growing agent having excellent hair-growth effects such as hair loss prevention and hair growth effects.

[0002]

BACKGROUND ART The causes of baldness and hair loss include activation of androgens in organs such as hair roots and sebaceous glands, decreased blood flow to hair follicles, excessive secretion of sebum, and abnormalities in the scalp due to production of peroxide. It has been considered that components for removing or reducing the above-mentioned causes have been added to conventional hair-growth and hair-growth agents.

[0003]

Problems to be Solved by the Invention However, conventional hair-growth and hair-growth agents do not always have sufficient hair-growth effects such as hair loss prevention and hair-growth effects.

[0004]

Means and Actions for Solving the Problems The present inventor has searched for a substance having an excellent hair loss preventing and hair-growing effect in order to solve the insufficient hair-growth effect as described above. By blending the medicine extract and the T-shape extract,
We have found a hair-growth / hair-growth agent that has excellent hair loss prevention, hair-growth and hair-growth effects, and has long-term safety.

That is, the present invention provides a hair restorer / hair restorer characterized by containing a T-shape extract and a Jujutsu extract.

[0006] Although the ten medicine extract alone has excellent hair loss prevention, hair growth and hair growth effects, as a result of pursuing even more excellent effects, the purpose can be achieved by adding a T-shape extract to the ten medicine extract. Was.

[0007] The clove extract used in the present invention is Myrtaceae Syzygium aromaticum Merrill et Pe
From the buds of rry (Eugenia caryophylata Thunb.), the ten-drug extract was obtained from Saururaceae dokudami (Houttuyni).
a cordata Thunb.) respectively. As a manufacturing method, a crude drug dried and chopped to an appropriate size is mixed with a solvent, for example, water, a lower alcohol such as methanol or ethanol or a lower alcohol containing water, a polyhydric alcohol such as propylene glycol or 1,3-butylene glycol, or a water-containing alcohol. It is purified by extraction with a polyhydric alcohol at room temperature or under warming conditions.

One example of a method for producing a T-shape extract is obtained by adding 5 parts of 50% ethanol to 1 part of a T-shape dry product, extracting the mixture at room temperature for one week, and then filtering. The letter is eugenol,
It contains essential oils such as safrole and acetyleugenol, triterpenoids such as stigmasterol and sitosterol, tannins, fatty oils, waxes and the like, and is used for aromatic gastric drugs, spices and the like.

The ten drugs contain essential oils such as decanoylacetaldehyde and lauryl aldehyde, and flavonoids such as quercitrin and isoquercitrin, and are widely used as diuretics and laxatives. However, it has never been used as a hair restorer / hair restorer. Since the extracts of genoshoko, Toji and Jujutsu which are the active ingredients of the hair restorer / hair restorer of the present invention do not show toxicity to the human body, the amount of the extract to the hair restorer / hair restorer is not particularly limited. It is preferable to add 0.001 to 10% by weight. 0.0
If it is less than 01% by weight, the effect of hair growth and hair growth cannot be sufficiently exhibited, and if it exceeds 10% by weight, no further hair growth effect can be expected.

[0010] Further, by blending the ginger extract, the synergistic effect with the T-shape extract and the Jujube extract produced a more excellent effect.

[0011] Geno-shoko extract is a product of Geraniaceae (Geranium thunbergii).
After drying the above-ground whole grass of Sieb. Et Zucc.), It was cut into appropriate size and extracted with a solvent. Gennoshoko is a plant containing tannins, flavonoids, etc., and is widely used as a gastrointestinal drug.

[0012] In the practice of the present invention, an extract of Toji, Jujutsu and Genoko may be sufficiently effective, but may be used in combination with a cell activating component or a blood circulation promoting agent conventionally used in hair growth and hair growth agents. It is possible.

The cell activator that can be used in the present invention includes:
Pantothenic acid and its derivatives (pantothenyl ethyl ether), photosensitizer No. 301, carrot extract, biotin,
Mononitroguaiacol, hinokitiol, allantoin, pentadecanoic acid glyceride and the like.

[0014] The blood circulation promoter that can be used in the present invention includes:
Carpronium chloride, Assembly extract, Pepper tincture, Cepharanthin, Benzyl nicotinate, Garlic extract, Touki extract, Gentian extract, γ-Oryzanol, Licorice, Minoxidil, Senkyu, Ginseng ginseng, Panax ginseng, Ginger, Jio, Aloe, Spironolactone, Vitamin B ₆ hydrochloride, D-camphor, DL-camphor, DL-α-tocopherol, garlic iodide extract, DL-α-tocopherol linoleate, inositol hexanicotinate, vitamin E, dextran sulfate sodium, nicotinic acid, DL- α-tocopherol nicotinic acid ester,
Butoxyethyl nicotinate, methyl nicotinate, vanillyl amide nonanoate, DL-α-tocopherol succinate, DL-α-tocopherol acetate, capsicum tincture, cantaristin tincture, show tincture tincture, and the like, in particular, cepharanthin, DL-α -Tocopherol, garlic iodide extract, assembly extract, DL-α
-Tocopherol nicotinic acid ester, benzyl nicotinate, vanillyl amide nonanoate, DL-α-tocopherol acetate, pepper tincture, cantaris tincture, ginger tincture, and the like are preferable from the viewpoint of hair-growth effect.

[0015] In addition to the above-mentioned active ingredients, benzalkonium chloride, salicylic acid, chlorhexidine hydrochloride, photosensitive element 201, photosensitive element 301, chlorhexidine gluconate solution, chlorxylenol, trichloro Disinfectants such as carbanilide, halocarban, mononitroguaiacol, glycyrrhizin and its derivatives, diphenhydramine hydrochloride, guaiazulene, carbenoxolone disodium, sicon extract, anti-inflammatory agents such as age, l-menthol, hydrocortisone acetate, prednisolone, sodium hyaluronate; Humectants such as glycerin, sodium pyrrolidonecarboxylate, propylene glycol, mini sasanishi extract, chondroitin sulfate, cordyceps extract, saffron extract, etc., horns such as salicylic acid, resorcinol and lactic acid Solubilizers, topical stimulant peppermint oil,
Estrone, estradiol, estrogen such as ethinyl estradiol, pyridoxine and derivatives, sulfur, thioxolone, vanside, antiseborrheic agents such as lecithin, amino acids, cystine, cysteine, methionine,
Nutrients such as serine and vitamins, oils (isopropyl myristate, lecithin, squalane, etc.), surfactants (polyoxyethylene sorbitan fatty acid ester, sorbitan fatty acid ester, polyoxyethylene fatty acid ester, glycerin fatty acid ester, etc.) Polyhydric alcohols (propylene glycol, glycerin, macrogol, etc.), antioxidants (dibutylhydroxytoluene, isopropylgallate, etc.), sequestering agents (ethylenediaminetetraacetate or its salt, etc.), pigments, fragrances, etc. can be appropriately compounded. it can.

The hair restorer / hair restorer of the present invention comprises one to several times a day,
An appropriate amount is applied to the scalp and used. In addition, the hair growth of the present invention
The dosage form of the hair restorer is not particularly limited, and conventionally known hair tonics, hair lotions, hair creams, aerosols, ointments and the like can be used.

[0017]

Next, embodiments of the present invention will be described, but the present invention is not limited to these embodiments.

[0018]

【Example】

 Examples 1-2

[Table 1] <Hair Growth Test> The back hair of a 7-week-old C3H mouse (♂) in the telogen period was shaved over 2 × 4 cm ² using an electric clipper and an electric razor. Each group consisted of 10 mice, 0.1 ml each day, at the shaved site,
The hair-growth and hair-growth agents of Examples 1-2 and Comparative Examples 1-3 shown in Table 1 were applied. In order to observe the state of hair regeneration, a photograph of the above shaved site was taken at a fixed magnification, and the ratio of the regenerated hair area (regenerated hair area / shaved area) was calculated using an image analyzer. Table 1 shows the average value of the regenerated hair area ratio (%) of each group on the 14th day after the start of the sample application.

<Practical test> Using the hair-growing and hair-growing agents of Examples 1 and 2 and Comparative Examples 1 to 3 shown in Table 1, 10 men, each of whom regularly suffers from a lot of hair loss, dandruff and itching ( 25-50
Aged) were tested for the effect of preventing hair loss, dandruff and itching. The method of use was basically twice a day, in the morning and before bedtime. When the hair was washed, an appropriate amount was applied to the scalp after the hair was washed and massaged. In addition, during the test period, we asked commercial shampoos to be used uniformly, and other rinsing agents,
Use of tonics, hairdressing agents, and treatments for perms and hair dyes were banned. Judgment of the effect is performed by a hairdresser once every two weeks, hair that has fallen off during hair washing is collected, the number of hair loss is measured, and the state of the hair root is observed and classified.
After the hairdresser's hair was washed, the condition was evaluated 48 hours later, and the presence or absence and degree of itch were confirmed by the consciousness of the person. The results were evaluated according to the following criteria, and the results are shown in Table 2.

(Evaluation Criteria) (1) Hair loss-Effective: The number of hair loss has decreased. The hair root is a clean club-shaped normal hair root. Invalid: The number of hair loss has not changed or has increased. Hair roots are abnormal hair roots with atrophy and deformation. (2) Dandruff (visual judgment) ・ Valid… Slightly dandruff-No dandruff is observed. ・ Invalid… Very dandruff is occurring ～ Drunk. (3) Itching (identity) ・ Valid ... Itching that you will forget after a while-You will not feel itching-Invalid ... There is itching that you can not stand-You can endure itching

[Table 2] As shown in Table 2, Examples 1 and 2 of the present invention are Comparative Examples 1 and 2.
Compared with No. 3, the regenerated area ratio was excellent at 75% or more in the hair growth test, and a remarkable effect in preventing hair loss, dandruff and itch was also observed in the practical test.

Further, the following hair-growing / hair-growing agents of Examples 3 to 14 show the remarkable effects on hair loss prevention, dandruff and itching prevention as in Example 1.

Example 3 Parts by weight T-shaped extract 3 Jujube extract 1 Gennoshoko extract 2 Ethanol 65 Propylene glycol 5 Photosensitizer 301 0.1 Minoxidil 0.5 DL-α-Tocopherol linoleate 0.1 Purified water Appropriate amount The above-mentioned lotion-type hair restorer / hair restorer was prepared.

Example 4 Parts by weight T-shape extract 1 Jujube extract 3 Geno ginger extract 2 Carboxyvinyl polymer 0.4 Ethanol 40 Propylene glycol 1 Glycerin 5 Carrot extract 0.2 Assembly extract 0.2 Diisopropanolamine 0.4 Purified water suitable amount The above-mentioned gel-type hair-growth / hair-growth agent was prepared.

Example 5 Parts by weight T-shape extract 5 Jujube extract 5 Genoshoko extract 5 Polyoxyethylene (20) sorbitan monostearate 5 Sorbitan monostearate 3 Cetanol 2 Stearyl alcohol 2 Liquid paraffin 10 Vitamin E acetate 0. 2 Minoxidil 1 Pantothenyl ethyl ether 0.5 Inositol hexanicotinic acid ester 0.1 Methyl parahydroxybenzoate 0.1 Propylene glycol 10 Purified water Appropriate amount The above-mentioned cream type hair growth and hair growth agent was prepared.

Example 6 parts by weight T-shape extract 1 Jujube extract 1 Genoshoko extract 1 Hinokitiol 0.5 Cepharanthin 0.5 Benzyl nicotinate 0.3 Panax ginseng 0.1 Propylene glycol 5 Polyoxyethylene (20) monooleate 5 Ethanol 50 Liquefied petroleum gas 4 Purified water Appropriate amount The above-mentioned aerosol-type hair growth and growth agent was prepared.

Example 7 Parts by weight T-shape extract 2 Jujube extract 2 Genoko extract 4 Carboxyvinyl polymer 0.4 Ethanol 40 Propylene glycol 5 Diisopropanolamine 0.4 Biotin 0.5 Pepper tincture 0.3 Cepharanthin 0.0 3 Vitamin E 0.1 Nicotinic acid 0.1 Purified water Appropriate amount The above-mentioned gel-type hair-growth / hair-growth agent was prepared.

Example 8 Parts by weight Geno ginger extract 2 T-shaped extract 3 Jujube extract 3 Mononitroguaiacol 1 Benzyl nicotinate 0.5 Garlic extract 0.1 1,3-butanediol 2 Propylene glycol 4 Polyoxyethylene ( 20) Polyoxypropylene (6) decyltetradecylether 3 ethanol 55 Purified water qs The above-mentioned lotion-type hair-growth / hair-growth agent was prepared.

Example 9 parts by weight T-shape extract 3 Jujube extract 3 Genoshoko extract 5 Allantoin 0.2 Touki extract 0.1 Spironolactone 0.1 Gentian extract 0.1 Glycyrrhetinic acid 0.2 Glyceryl monoisostearate 1 Propylene glycol 5 Polyoxyethylene (20) sorbitan monooleate 1.5 Ethanol 70 Purified water Appropriate amount The above-mentioned lotion-type hair-growth / hair-growth agent was prepared.

Example 10 Parts by weight T-shape extract 2 Jujube extract 3 Genoko extract 1 Glyceride pentadecanoate 0.1 γ-Oryzanol 0.1 Licorice 0.2 Butoxyethyl nicotinate 0.1 Ethanol 65 Propylene glycol 5 Purification Water appropriate amount The above-mentioned lotion-type hair-growth / hair-growth agent was prepared.

Example 11 parts by weight T-shape extract 1 Jujube extract 5 Geno ginger extract 3 Sengoku 0.1 Ginseng 0.1 Ginger 0.1 Geo 0.1 Aloe 0.5 Carboxyvinyl polymer 0.4 Ethanol 40 Propylene glycol 1 Glycerin 5 Diisopropanolamine 0.4 Purified water Appropriate amount The above-mentioned gel-type hair-growth / hair-growth agent was prepared.

Example 12 parts by weight T-shape extract 2 Jujube extract 1 Geno ginger extract 3 Vitamin B ₆ hydrochloride 0.1 DL-camphor 0.2 DL-α-tocopherol 0.2 Methyl nicotinate 0.1 Poly Oxyethylene (20) sorbitan monostearate 5 Sorbitan monostearate 3 Cetanol 2 Stearyl alcohol 2 Liquid paraffin 10 Methyl parahydroxybenzoate 0.1 Propylene glycol 10 Purified water Appropriate amount The above-mentioned cream type hair growth and hair growth agent was prepared.

Example 13: parts by weight T-shape extract 1 Jujube extract 1 Genoshoko extract 4 Nonylate vanillylamide 0.1 DL-α-tocopherol succinate 0.1 DL-α-tocopherol acetate 0.2 Pepper tincture 1 Cantaris tincture 0.1 1,3-butanediol 5 Polyoxyethylene (60) hydrogenated castor oil 0.4 Octyldodecyl myristate 1 Glyceryl monoisostearate 1 Ethanol 65 Purified water Appropriate amount A hair restorer was prepared.

Example 14 Parts by weight T-shape extract 1 Jujube extract 2 Geno ginger extract 2 Garlic iodide extract 0.1 DL-α-tocopherol nicotinic acid ester 0.1 Ginger tincture 0.2 D-Camphor 1 Sodium dextran sulfate, 0.5 Propylene glycol 5 Polyoxyethylene (20) monooleate 5 Ethanol 50 Purified water Appropriate amount Liquefied petroleum gas 4 The aerosol-type hair growth and hair growth agent was prepared.

[0034]

EFFECT OF THE INVENTION By blending the T-shape extract and the Jujube extract, it is possible to provide a hair-growing / hair-growing agent which has excellent hair loss-preventing, hair-growing / hair-growing effects and a long-term safety.

Claims (3)

[Claims] 1. A hair restorer / hair restorer comprising a T-shaped extract and a Jujube extract. 2. The hair restorer / hair restorer according to claim 1, further comprising a ginger extract. 3. The hair restorer / hair restorer according to claim 1, which comprises one or more members selected from the group consisting of a cell activator and a blood circulation promoter.