JPH05286837A - Hair-raising agent - Google Patents

Abstract

PURPOSE:To provide the hair-raising agent excellent in effects on hair growth, hair raising, alopecia prevention, dander prevention, etc. The extract of the Aconiti Tuber is preferably compounded with the hair-raising agent in an amount of 0.0001-20wt.% (expressed in terms of dried product) based on the total amount of the hair-raising agent, and the total amount of a blood circulating agent or hair mother cell-activating agent may contain the amounts given in the table. CONSTITUTION:The hair-raising agent comprises by compounding the extract of the Aconiti Tuber and the ingredients having a blood circulation-stimulating action and/or a hair mother cell-activating action.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair nourishing agent which is excellent in hair growth, hair nourishment, hair loss prevention and dandruff prevention.

[0002]

2. Description of the Related Art Alopecia is considered to be caused by various factors intricately intertwined with each other, and the occurrence mechanism is not yet fully understood. Conventionally, hair nourishing agents containing various hair mother cell activating or blood circulation promoting components have been used for preventing or treating hair loss.
It is not effective enough to suppress hair loss and promote hair growth and hair growth.

[0003] The fusi, which is used as a raw material for the hair nourishing agent of the present invention, has been described in China since ancient times as a herbal sutra and is known as an important crude drug that is widely used in various Kampo prescriptions in Kampo medicine. ) Aconitum species (Aconitum specie)
s) tuberous root. Japanese Patent Application Laid-Open No. 3-271213 proposes a hair growth and hair growth agent characterized by containing an extract of the root, stem or leaf of aconite, which is the base plant, but the extract of aconite alone is used. The hair growth and hair growth effects were insufficient.

[0004]

DISCLOSURE OF THE INVENTION In view of the above circumstances, the present inventor has conducted extensive studies and, as a result, has found that the extract of aconite and a component having a blood circulation promoting action and / or a component having a hair mother cell activating action are identified. By blending, the safety is high,
The present inventors have completed the present invention by finding that they show excellent effects in promoting mouse hair growth and human hair growth, and exhibit a remarkable effect in preventing dandruff. That is, an object of the present invention is to provide a hair nourishing agent having excellent effects such as hair growth, hair nourishment, hair loss prevention, and dandruff prevention.

[0005]

The present invention relates to a hair nourishing agent which comprises an extract of Fuzi and a component having a blood circulation promoting action and / or a component having a hair mother cell activating action.

[0006] The raw material crude drug used as a raw material of the hair nourishing agent of the present invention is a Ranunculacea family.
e) aconitum plant (Aconitum spec)
As long as it is prepared from the root root of (ies), the origin and the place of origin thereof are not limited. Also, in general,
Aconite plants contain the highly toxic aconitine alkaloids, and caution is required when using them, so it is more preferable to use what is called a processed astringent that has been prepared for detoxification such as heat treatment. Good.

[0007] Examples of the root plant of Fuzi are, for example, the cultivar Aconitum c.
armichaeli Debx. ), Wild species (Aconitum kusnesoffii Re) from all over China
ichb. ) Such as Korean honey beetle (Aco
nitum triphyllum Nakai, Aconitum coreanum
Rap. ), Japanese octopus beetle (Aconit)
um japonicum Thunb. ), Aconitum chinese Pax
t. ) And the like. Especially, the agar beetle produced in Sichuan Province of China is preferable in terms of quality stability and supply with a certain cultivation method.

As the detoxification processing method, Japanese Patent Publication No. 37
No. 18498 proposed, tuber roots in an autoclave at 100 to 130 ° C., pressure 1.0 to 1.5 kg / c.
The method of preparing by applying pressure and heat treatment for m2 for 20 to 40 minutes is a particularly preferable method because a crude drug can be stably produced in a simple, effective and safe manner. As an example of the product prepared by this method, the product name “Processed Bushi powder” of the Japanese Pharmacopoeia standard product
Is mentioned. In addition, as a method mainly performed in China, water-washed tuberous roots are dipped in bitter broth for several days to dry, or further steamed, a method of preparing by drying after repeating treatments such as boiling, or For example, there is a method of washing the tuber with water, dividing it vertically, immersing it in ash at the time of freshness, heating it, pressurizing it, and drying it. As an example prepared by this method, the one commercially available as Fuzi gourd produced in Sichuan, China (referred to as Fuzi Fuzi in Japan) is preferable because it is sufficiently detoxified with a certain quality.

[0009] The extract of the adzuki bean of the present invention refers to a component which is transferred from the adduct to the solvent when the adzuki bean is extracted with a solvent, and the extract can also be used in a dried state after removing the solvent. Also, it can be used in a state of being dissolved in a solvent. In the latter case, the extraction solvent will form part of the base in the hair restorer of the invention.

As the solvent, water, alcohols such as methanol, ethanol, butanol, ethers such as ethyl ether, dioxane, ketones such as acetone, aliphatic hydrocarbons such as pentane and hexane,
Cyclohexane, esters such as ethyl acetate and the like can be used. When the extract is removed by solvent and used as a dried product, any of the above-mentioned solvents can be used alone or in combination. However, when the extract is used in a state of being dissolved in a solvent, it is preferable to use water, ethanol, or a mixture thereof, which has no harmful effect on the human body.

Upon extraction, the adjunct may be used as it is, or may be crushed or crushed to improve contact with a solvent. Although the ratio of the adjunct to the solvent is not particularly limited, the adjunct 1 is taken into consideration from the viewpoint of extraction efficiency and convenience.
Preference is given to using 100 to 5000 ml of solvent per 00 g. The extraction temperature is conveniently in the range of room temperature to the boiling point of the solvent under normal pressure, and the extraction time is preferably in the range of 30 minutes to 2 weeks, although it varies depending on the extraction temperature, the presence or absence of stirring and the like.

The components having a blood circulation promoting action and / or hair mother cell activating action used in the hair nourishing agent of the present invention include the conventionally used senburi extract, murasakisenburi extract, ginseng extract, and bamboo shoot ginseng extract. Liquid, vitamin E,
Vitamin E acetate, Vitamin E nicotinate, diisopropylamine dichloroacetate, carpronium chloride, cepharanthin, D-pantothenyl alcohol,
D-pantothenyl ethyl ether, acetyl pantothenyl ethyl ether, calcium pantothenate, sodium mononitroguaiacol, biotin, photosensitizer 301
No., capsicum tincture, canthari tincture, ginger tincture, nicotinamide, benzyl nicotinate, etc.

[0013] In each of the above-mentioned components, those specifically specified as a blood circulation promoting agent or a hair mother cell activating agent, and further, for example, as in the case of the assembly extract, a blood circulation promoting and hair mother cell activating action. To use the effect together,
Either of them can be used in the present invention.

Here, in the present invention, the object of the present invention can be further enhanced by blending both the above-mentioned blood circulation promoter and hair matrix activating agent. Of the above components, the extracts of natural products such as senburi extract, murasakisenburi extract, ginseng extract, and Takebushi ginseng extract are not specified with respect to the production method, but an outline of each production method is given. It is described below.

[Method for producing assembly extract] Assembly (S
(Wertia japonica Makino) is a dry pulverized product of the whole flowering flowering plant that is cold-soaked or hot-soaked in ethanol or hydrous ethanol, and then filtered to obtain an extract. The extract obtained by the following method was used in the examples. 50 g of the ground crushed product was digested in 250 ml of 90 v / v% ethanol (hereinafter, v / v% is abbreviated as%) at a temperature of 40 to 50 ° C., filtered and the residue was extracted again in the same manner. 0.51 was obtained. This was concentrated under reduced pressure, 100 ml of purified water was added to the concentrate, and after aging for one week, the extract obtained by filtering off insoluble matter was concentrated under reduced pressure, and then ethanol was added to bring the ethanol concentration of the extract to 50%. It was adjusted so as to obtain 100 ml of the Aspergillus flavus extract.

[Manufacturing method of Murasakusenburi extract] Murasakusenburi (Swertia pseudochin)
This is an extract obtained by immersing a dry pulverized product of whole flowering plants (ensis Hara) in ethanol or hydrous ethanol by cold or hot digestion and filtering. The extract obtained by the following method was used in the examples. 50 g of the pulverized product of Murasakusemiburi was extracted with 750 ml of 90% ethanol for 2 days at room temperature, filtered, and the residue was similarly extracted again 3 times to obtain 2.25 l of extract. This was concentrated under reduced pressure, ethanol and purified water were added to the concentrate to adjust the ethanol concentration of the extract to 70%, and after aging for 1 week, the insoluble matter was filtered off to obtain 50 ml of the purple squirrel extract. Obtained.

[Manufacturing method of ginseng extract] Panax ginseng CA Meye
It is an extract obtained by cold-soaking the dried pulverized product of 5 to 6-year-old root of r) in ethanol or hydrous ethanol and filtering. The extract obtained by the following method was used in the examples. Panax ginseng 5-6 years root dry crushed product 50g 90
% Of 200% ethanol for 1 week, and the ethanol of the extract obtained by filtration is distilled off under reduced pressure. Purified water is added to adjust the ethanol concentration of the extract to 50%.
After aging this for 7 to 10 weeks in a cold place, the insoluble matter was filtered off to obtain 100 ml of ginseng extract.

[Production Method of Takebushi Ginseng Extract] Panax japonicum CA Mey
It is an extract obtained by cold-soaking the dried and crushed root of (er) in ethanol or hydrous ethanol and filtering. The extract obtained by the following method was used in the examples. 50 g of dried crushed carrot root is mixed with 90% ethanol 2
It was soaked in 00 ml for 1 week, and ethanol of the extract obtained by filtration was distilled off under reduced pressure. Purified water was added to adjust the ethanol concentration of the extract to 50%.
After aging for a week in a cold place, the insoluble matter was filtered off to obtain 100 ml of bamboo shoot ginseng extract.

The present inventor has conducted diligent research on the above-mentioned constituents to be mixed in the hair nourishment, and as a result, at least one selected from the group consisting of the extract of the aconite of the present invention and a blood circulation promoter or hair matrix activating agent. It has been found that the hair nourishing agent containing a combination of and has an effect such as an excellent hair-growth effect, hair-growth effect, hair loss prevention effect, and dandruff prevention effect due to its synergistic effect.

Further, the compounding amount of the extract of the hair-restoring agent is based on the total amount of the hair-retaining agent, and the amount of the extract of the agent is 0.
0001 to 20 Wt% (dry matter conversion), the blood circulation promoter or the hair matrix activator total amount may be the amounts shown below, and if the amount is less than the lower limit of the respective amounts, the effect of the present invention is not sufficient. On the other hand, even if the upper limit is exceeded, improvement in the effect commensurate with the increase cannot be expected.

That is, the amount of the above-mentioned blood circulation promoting agent or hair matrix activating agent used in the present invention is appropriately adjusted depending on each action and effect, the dosage form of the hair nourishing agent, etc. The compounding amount shown in is preferable. The blending amount was based on the total amount of the hair nourishing agent. In addition, the extract was described as the one obtained by the above extraction method. ──────────────────────────────────── Component blending amount (wt%) ─────── ──────────────────────────── Assemblage extract 0.5-20 Purple ginseng extract 0.5-10 Ginseng extract 0 1 to 10 Takebushi ginseng extract 0.1 to 10 vitamin Es 0.001 to 0.5 diisopropylamine dichloroacetate 0.01 to 5.0 carpronium chloride 0.01 to 5.0 cepharanthin 0.01 to 5. 0 Pantothenyl alcohols 0.01 to 2.0 Capsicum tincture 0.1 to 1.0 Nicotinic acids 0.1 to 1.0 Biotin 0.001 to 0.1 Mononitroglyciacol sodium 0.1 to 5. 0 Photosensitizer No. 301 0.001-0.1 ──────── ───────────────────────────

The hair nourishing agent of the present invention can be made into a dosage form such as a hairnic, a hair lotion, a hair cream, a shampoo, a rinse, a hair foam and a hair gel according to a conventional method.

The hair nourishing agent of the present invention includes pigments, fragrances, germicides, preservatives, keratolytic agents, anti-inflammatory agents, anti-androgens,
A hair nourishing agent, an antioxidant, a cooling agent, other herbal medicine extracts and the like can be appropriately added within the range where the object of the present invention is achieved.

[0024]

EXAMPLES The present invention will be described in detail below based on examples and comparative examples. The mouse hair growth promoting effect test method, human hair growth promoting effect test method and practical test method described in Examples are shown below.

(1) Mouse Hair Growth Promoting Effect Test C3H mice (male, 7 weeks old) were shaved with a clipper and shaver on the central hair of the back, and the sample was cut at the shaved site once a day per animal. 0.2 ml was applied. For each sample, 10 animals were used per group. On the fifteenth day after the start of the experiment, the back of the mouse was photographed, the hair cutting area and the hair growth area were calculated, the hair growth rate (%) was calculated, and the hair growth promoting effect was determined by the average value of 10 cases.

(2) Test method for human hair growth promoting effect: The hair of 10 test subjects who are male pattern baldness has a circular shape with a diameter of 1 cm at 5 cm above the ears on the head of the head. About 3 ml of the sample of Example or Comparative Example was applied to the left side of the shaved test site twice daily in the morning and evening, and compared with the untreated right side. Evaluation of the effect is 28 days after the start of the test,
20 hairs on each of the left and right test sites are shaved, and the average value (B) of the lengths of 20 hairs on the left side (applied Example or Comparative Example) is calculated as the length of 20 hairs on the right side (untreated). The value obtained by dividing the average value (A) of the sacks was obtained and evaluated. The determination result was shown by the average value of (B) / (A) of 10 test subjects.

(3) Practical test method Twenty test subjects who are male pattern baldnesses were evaluated for their effects after applying the sample to the head twice a day twice a day for 6 consecutive months. The test results were "hair bristling or increased hair loss", "less hair loss", "less dandruff" for each item of hair growth effect, hair loss prevention effect, and dandruff prevention effect. The number of people who answered

Production Example 1 (Preparation of extract of Fuzi) (1) A crushed product of dry root of Fuzi produced in Sichuan Province of China (commercially available as River Oozu or Zuizi) in an autoclave at 100 to 130 ° C. Pressure 1.0 to 1.5 kg / cm2,
Pressurize and heat treatment for 40 minutes. Azushi 100 processed
g to 1500 ml of 70% ethanol at room temperature (20-
Soak for 16 hours at 25 ° C) and collect the supernatant by filtration.
The mixture was concentrated under reduced pressure at ℃ for 3 hours, and the solvent was distilled off to obtain 11.7 g of a brown extract.

(2) Preparation Example 1 100 g of Shishibu Province, China processed in the same manner as in (1) was immersed in 1500 ml of 40% ethanol for 16 hours at room temperature (20 to 25 ° C.),
The supernatant was collected by filtration and concentrated under reduced pressure at 45 ° C. for 4 hours, and the solvent was distilled off to obtain 13.4 g of a brown extract.

(3) 50 g of Zhizizi (commercially available as Zhizi) produced in Sichuan Province of China was immersed in 500 ml of 70% ethanol for 16 hours at room temperature (20 to 25 ° C.), and the supernatant was filtered. After collecting and concentrating at 45 ° C. under reduced pressure for 2 hours and distilling off the solvent, 5.3 g of a brown extract was obtained.

(4) Japanese non-pharmacological standard product processing bush end 50
g to 500 ml of 40% ethanol at room temperature (20-2
After dipping at 5 ° C. for 10 hours, the supernatant was collected by filtration, concentrated under reduced pressure at 45 ° C. for 3 hours, and the solvent was distilled off to obtain 6.1 g of a brown extract.

Examples 1 to 12 and Comparative Examples 1 to 12 (Oily Hair artic) Each of the articulations obtained by blending the extract of Fusi with a blood circulation promoter or hair cell activating agent in the following component compositions. Was prepared and the above-mentioned tests were carried out.

(1) Composition Ingredients Amount (wt%) ─────────────────────────────────── Olive oil 5.0 (A) Isopropyl myristate 5.0 Isopropylmethylphenol 0.05 Polyoxyethylene nonylphenyl ether 0.5 0.5 ──────────────────────── ──────────── (B) Extracts of Fusuko described in Tables 1 and 2 ───────────────────────── ──────────── Methylparaben 0.1 (C) Ethanol 60.0 Glycerin 5.0 Purified water 100.0 Residual amount to be ─────────────── ──────────────────── (D) Blood circulation promoter or hair matrix activator described in Tables 1 and 2 ─────────── ────────────────────────

(2) Preparation method The water-soluble components in the components (B) and (D) are dissolved in the component (C), the other components (D) are dissolved in the component (A), and after each is uniformly dissolved. , (A) component and (C) component are mixed with stirring and dispersed, and then filled in a container. At the time of use, the contents should be evenly dispersed by shaking.

(3) Characteristics As shown in Table 1, Comparative Examples 1 to 4 in which the extract of Aconi of the present invention is alone and Comparative Examples 5 to 12 in which only the blood circulation promoting or hair mother cell activating substance is alone promotes hair growth. The effect was low, and hair growth and dandruff prevention effects were not observed. On the other hand, the hair nourishing agent of the present invention of Examples 1 to 12 in which the extract of the abbot of the present invention and the blood circulation promoting or hair mother cell activating substance are blended at the same time,
As shown in Table 2, clearly good results were shown in all the tests. In addition, in Examples 1 to 12, skin irritation did not occur in various tests on human skin.

[0036]

[Table 1]

[0037]

[Table 2]

Examples 13 to 28, Comparative Examples 13 to 20 (Scalp Treatment) Each of the scalp treatments was carried out by adding the extract of Fuzi and a blood circulation promoter or hair cell activating agent in the component composition described below. It was prepared and the above-mentioned tests were carried out. (1) Composition Ingredients Amount (wt%) ─────────────────────────────────── Liquid paraffin 30. 0 Stearic acid 5.0 (A) Cetanol 5.0 Sorbitan monooleate 3.0 Polyoxyethylene sorbitan monooleate 3.0 Isopropylmethylphenol 0.1 ──────────────── ──────────────────────────── (B) Extracts of apricots Described in Tables 3 and 4 ────────────────── ────────────────── Methylparaben 0.2 (C) Glycerin 5.0 Perfume 0.2 Purified water Remaining amount to make the total amount 100.0 ────── ───────────────────────────── (D) Blood circulation promoter or hair matrix activator Table 3 and Table 4 ───────────────────────────────────

(2) Preparation method The water-soluble components in the components (B) and (D) are added to the component (C), and the other components (D) are added to the component (A), respectively, at a temperature of 70 ° C. After dissolution by heating, (A) component and (C)
The ingredients were mixed uniformly with stirring. Then, each scalp treatment was prepared by cooling to room temperature with stirring.

(3) Characteristics As shown in Tables 3 and 4, Comparative Examples 13 and 14 which are the sole extract of the present invention and Comparative Examples 15 to 20 which are the blood circulation promoting or hair cell activating substance alone. The effect of promoting hair growth was low, and the effects of nourishing hair and preventing dandruff were not observed. On the other hand, the hair nourishing agents of the present invention of Examples 13 to 28, in which the extract of the abalone of the present invention and the blood circulation promoting or hair mother cell activating substance are simultaneously mixed, show obviously good results over all the tests. Indicated. In Examples 13 to 28, skin irritation did not occur in various tests on human skin.

[0041]

[Table 3]

[0042]

[Table 4]

[0043]

Industrial Applicability As described above, it is apparent that the present invention provides a hair nourishing agent which exhibits a remarkable effect of promoting hair growth and is excellent in effects such as hair growth, hair nourishment, hair loss prevention, and dandruff prevention.

Claims (2)

[Claims] 1. A hair nourishing agent comprising an extract of Fuzi and a component having a blood circulation promoting action and / or a hair mother cell activating action. 2. The component having a blood circulation promoting action and the component having a hair mother cell activating action described above include a senburi extract, a purple tern extract, a ginseng extract, a bamboo ginseng extract, a vitamin E, a vitamin E acetate, Vitamin E nicotinate, diisopropylamine dichloroacetate, carpronium chloride, cepharanthin, D-pantothenyl alcohol, D-pantothenyl ethyl ether,
At least a substance selected from the group consisting of acetyl pantothenyl ethyl ether, calcium pantothenate, sodium mononitroguaiacol, biotin, photosensitizer No. 301, capsicum tincture, canthari tincture, ginger tincture, nicotinic acid amide, and benzyl nicotinate. The hair nourishing agent according to claim 1, which is one.