KR100773421B1 - Compositions for preventing hair loss, or promoting hair raising or hair growth, and processes for preparing the same - Google Patents

Abstract

A composition obtained from dried Castanea sp. leaves, Zanthoxylum schinifolium and Zanthoxylum piperitum is provided to treat hereditary hair loss which is known to be most hard to treatment and hair loss caused by inflammatory diseases such as seborrheic dermatitis and psoriasis and significantly alleviate itchness. A composition for preventing hair loss and promoting hair growth is prepared by the method comprising the steps of: (a) boiling 300g of dried Castanea sp. leaves, 20g of Zanthoxylum schinifolium and 20g of Zanthoxylum piperitum in 20-40 liters of purified water for 2-4 hours; (b) after cooling the boiled product down to a temperature of 40-60 deg.C so as to remove solid matters therefrom, adding 4-6 liters of purified water thereto and then boiling it for 2-4 hours; and (c) repeating the steps (a) and (b) 3-5 times. The composition further comprises a pharmaceutically or a cosmetically acceptable carrier selected from the group consisting of a surfactant, an emulsifier, a thickener, an antiseptic, an anti-oxidant, a perfume and a mixture thereof.

Description

Hair loss prevention, hair growth promoting or hair growth composition, and a method for producing the same {Compositions for preventing hair loss, or promoting hair raising or hair growth, and processes for preparing the same}

1a to 1c are photographs before and after a single period of application of a single extract of dry chestnut leaves to the hair of a male suffering from hereditary alopecia;

Figures 2a to 2d are photographs before and after the application of the combination extract of dried chestnut leaves, vinegar and echidna to the hair of a male suffering from hereditary alopecia and after a certain period of time.

The present invention prevents hair loss, the composition and for hair growth promoting or hair growth relates to a method of manufacturing the same and, more particularly, as an active ingredient, the dried chestnut (Castanea sp.) Leaf, Japanese pepper tree (Zanthoxylum schinifolium) and second linden (Zanthoxylum It relates to a composition for preventing hair loss, promoting hair growth or hair growth, containing a water extract of piperitum ) and a method for producing the same.

Background Art Conventionally, various types of hair growth and hair growth agents have been used for the prevention and treatment of physiological symptoms such as baldness, lean hair, dandruff, and fatty moisture. Generally, as a compounding agent of a hair growth / hair growth agent, the thing mainly aimed at promoting blood circulation of a scalp, activating hair hair cells, suppressing lipid secretion of a scalp, and nourishing the hair is used. For example, as this type of hair growth and hair growth agent, pentadecanoic acid glycerides, separanchin, bitter grass sugar extract, soluble cystine, ginseng extract, l-menthol, isopropylmethylphenol, glytilinic acid, tocopherol acetate, hinokithiol It is known to mix red pepper tink, licorice extract, nicotinic acid amide, salicylic acid and the like. Hair growth and hair growth agents are effective for promoting hair growth and hair growth, preventing hair loss, developing dandruff or itching, and are required to have high safety without side effects or skin irritation due to long-term use, but all of these requirements are met. Hair regrowth and hair growth agents have not been developed yet.

The inventor of the present invention is a chestnut ( Castanea ) in Korea Patent Application No. 2004-107202 sp.) has applied for a hair external preparation having hair loss prevention and hair growth promoting effect characterized in that it contains an extract of a plant. Although the hair external preparation of the above application shows an excellent hair growth effect, there is still room for improvement in terms of hair growth and hair growth effects, and in particular, there is a problem that severe itching is accompanied in the process of improving hair loss.

Meanwhile, Korean Patent Application No. 2005-43599 discloses an extract mixture (A) obtained by iii) washing and drying cornus oil, green tea leaves and ginkgo biloba leaves in water at 60-80 ° C. for 2-3 minutes, and then extracting the extract with water. To ˜60 parts by weight, ii) Chopi leaves and Sancho fruits were immersed in Jiji water and dried to remove the toxicity, and then 15-25 parts by weight of the extraction mixture (B) obtained by extracting the extract with ethyl alcohol was added. Hair growth, characterized in that prepared by mixing, emulsifying and stirring a mixture of oil, shea butter, honey, natural soy lecithin, natural tocopherol and camellia oil (C) 25-35 parts by weight, and then immersing the porous ceramic for 24 to 48 hours Disclosed is a method for preparing an accelerator composition.

However, there has been no known hair growth and hair growth agent using the water extract of the combination consisting of dried chestnut leaves, vinegar and bark.

As a result of continuous research to develop better hair loss prevention, hair growth promotion and hair growth agents, the inventors have found that the synergism between the three components of dried chestnut leaves, Japanese herbaceous and bark tree extracts is unexpected. In addition to having significantly improved hair loss prevention, hair growth and hair growth effects, the present inventors have found a new and surprising fact that remarkably alleviates the itch associated with hair loss improvement.

Accordingly, a first object of the present invention is to provide a hair loss preventing, hair growth promoting or hair growth composition containing a combination of dried chestnut leaves, medicinal herb and bark tree extract as an active ingredient.

It is a second object of the present invention to provide a method for preparing the composition.

The first aspect of the present invention as an active ingredient, 200 ~ 400 parts by weight of dried chestnut ( Castanea sp.) Leaves, 10-30 parts by weight of vinegar ( Zanthoxylum schinifolium ) and 10-30 parts by weight of Zanthoxylum piperitum It relates to a composition for preventing hair loss, promoting hair growth or hair growth containing water extract.

The second aspect of the present invention

Ⅰ) Add 20 ~ 40 g of dried chestnut ( Castanea sp.) Leaves, 10 ~ 30 g of Zanthoxylum schinifolium and 10 ~ 30 g of Zanthoxylum piperitum to 20 ~ 40 L of purified water and boil for 2 ~ 4 hours. step;

Ii) cooling the boiled product to 40-60 ° C. to remove solids, and then adding 4-6 L of purified water and raw material of step iii) to boil for 2-4 hours; And

Iii) repeating step ii) 3 to 5 times:

It relates to a method for producing a composition for preventing hair loss, promoting hair growth or hair growth.

Hereinafter, the present invention will be described in detail.

Dried chestnut ( Castanea sp.) Leaf, which is the first raw material used in the present invention, is not a raw leaf of chestnut and is a deciduous leaf. Chestnut is a deciduous arborescent of the dicotyledonous oak tree oak family. Less is known as cis (Castanea crenata var. Dulcis). It is mainly distributed in temperate regions such as Asia, Europe, North America, and North Africa, and its habitat is at the foot of the mountain or the field bank, and is 10-15 m high and 30-40 cm in diameter. Chestnut is known to have 13 species in temperate regions such as Asia, Europe, North America, and North Africa. Important species used for fruit are Japanese chestnut ( C. crenta ), European chestnut ( C. sativa ), Chinese chestnut ( C. mollissima ), and American chestnut ( C. dentata ). In Korea, it has been grown in a way that has been left alone. Although there were not many distinct varieties, Pyongyang chestnut (Hamjong chestnut) and Yangju chestnut (fire chestnut) named as local specialties were famous. By 1958, chestnut lumps from outside had been so severely damaged that they were almost exterminated, bringing pest-resistant varieties from Japan. Since 1961, at the forestry test site, it has begun to select the best species of chestnut-resistant species among the traditional Korean species, and announced about 10 varieties. In the present invention, the bark of Castanea sp. Uses a chestnut bar, a chestnut other than the cassia , for example, beech ( Fagus multinervis Nakai), horse chestnut ( Aesculus hippocastanum ), etc. to exhibit the desired effect properly. It was confirmed that it could not. In addition, when using the leaves of the chestnut bar has been confirmed that can exhibit a better effect than when using flowers, roots, stems, branches, etc. (see Korean Patent Application No. 2004-107202), in the present invention It is preferable to collect fallen leaves and to dry them sufficiently.

The second raw material used in the present invention ( Zanthoxylum schinifolium ) is a deciduous shrub of the dicotyledonous rats Fructus ulciaceae , the fruit is a capsule, round, 4 mm in length, greenish brown, split into three when ripe and black. Seed comes out. Fruits are picked before ripening and oiled from ripe seeds. In oriental medicine, the fruit peel is used as a herb called Yacho (野 초), which eliminates cold abdominal pain, stops vomiting and diarrhea, and is known to be effective in roundworms, liver dystomies, toothaches and seborrheic dermatitis. It is similar to the bark tree, but has one thorn at the bottom of petiole, the fruit is greenish brown, and has different petals. In the present invention, the vinegar can be used irrespective of parts such as flowers, roots, stems, branches, fruits, leaves, and more preferably, fruit is used. Fruits can be used both raw and dried.

The third raw material used in the present invention, Zanthoxylum piperitum ( Zanthoxylum piperitum ) is a deciduous shrub with a dicotyledonous group of Lee Fung, a group of Rhesus ulciaceae, the leaves are shifted, the radix is once the upper right biplane and the flowers bloom in May to June. Young leaves are used as edible, fruit as medicinal or spice (香味 料), bark (樹皮) is called epoch and is used to catch fish. In the present invention, the bark tree can be used irrespective of parts such as flowers, roots, stems, branches, fruits, leaves, and more preferably, leaves are used. The leaves can be either fresh or deciduous or dried.

In the composition according to the present invention, dried chestnut leaves, vinegar and bark tree are preferably used in combination of 200 to 400 parts by weight, 10 to 30 parts by weight and 10 to 30 parts by weight, respectively, within the above weight ratio range. This is because the synergy between the three components can be maximized, and it is difficult to obtain the synergistic effect as desired outside the above range. Therefore, the optimal weight ratio between the three components for preventing hair loss, promoting hair growth or hair growth effect will also form an important technical feature of the present invention. In particular, it is most preferable to use dried chestnut leaves, vinegar and bark tree in combination at 300 parts by weight, 20 parts by weight and 20 parts by weight.

The composition according to the present invention may be prepared by combining the three components with water, for example, purified water, preferably extracted with hot water of 98 ~ 100 ℃. In one example, the composition according to the invention

Iii) 200 to 400 g of chestnut ( Castanea sp.) Leaves dried in 20 to 40 l of purified water, especially 30 l, in particular 300 g, 10-30 g of vinewood, in particular 20 g and 10-30 g of vinewood, in particular 20 adding 2 g to 4 hours, in particular 3 hours;

Ii) cooling the boiled product to 40-60 ° C., in particular 50 ° C., to remove solids, and then adding 4-6 L of purified water, in particular 5 L and step iii) to boil for 2-4 hours, in particular 3 hours; And

Iii) repeating steps ii) 3-5 times, especially 4 times:

It may be prepared by a method comprising a.

Since the purpose of repeating the heating extraction process as described above is mainly for the concentration of the active ingredient, the active ingredient may be concentrated in a method such as reduced pressure concentration of the solution from which the first active ingredient was extracted. Since the solution from which the active ingredient is extracted is susceptible to corruption, it is preferable to keep refrigerated.

The composition of the present invention further contains a pharmaceutically or cosmetically acceptable carrier, so that the conventional formulation of creams, lotions, tonics, sprays, aerosols, oils, solutions, suspensions, gels, ointments, emulsions, waxes, pastes and the like. It can be prepared as. The composition of the present invention usually contains a base, and if necessary, other components generally used as pharmaceutical or cosmetic raw materials may be appropriately blended. The base of the composition of the present invention may be used as long as it is commonly used, examples thereof include purified water, mineral water, ethanol, glycerin, squalene, 1,3-propylene glycol, 1,3-butylene glycol, castor oil, Tsubaki oil and liquid petrolatum. Examples of other components to be incorporated into the composition of the present invention include, but are not limited to, surfactants, emulsifiers, thickeners, preservatives (eg, methyl paraoxybenzoate), antioxidants, fragrances, and the like.

In addition to the above components, the composition of the present invention may include components that may serve to supply nutrients to hair follicles or hair growth promoting auxiliary components that are commonly used. For example, vitamins, amino acids, animal and vegetable oils, sodium chloride And the like, but are not limited to these. Their amount is preferably 0.0001 to 10% by weight, in particular 0.01 to 1% by weight of the total composition. In this case, the vitamins include, but are not limited to, vitamin A, vitamin B1, vitamin B2, niacin (nicotinic acid), vitamin C, vitamin E, sodium pantothenate, potassium pantothenate, biotin H (vitamin H), and the like. Amino acids include, but are not limited to, waveguides. Animal and vegetable oils include, but are not limited to, horse oil, egg oil, olive oil, camellia oil, rapeseed oil, sesame oil, germ oil, and the like.

The composition of the present invention can be used by a method such as direct application or scattering on hair or scalp. Hair to which the composition of the present invention is applied includes hair follicles and hair follicles of the head, hair and eyelashes, and eyelashes, beards, armpits, pubic hair, and all parts of the hair root and hair follicles throughout the body. Accordingly, the present invention provides a hair tonic, hair lotion, hair cream, hair spray, hair mousse, hair gel, hair conditioner, hair shampoo, hair rinse, hair pack, hair treatment, eyebrow regrowth, eyelash regrowth or eyelash nutrient, or for pets It can be used as a shampoo and pet rinse.

The dose of the composition according to the present invention should be appropriately determined in consideration of sex, age, alopecia, hair condition and the like. Usually, the daily dose for adults can be applied 1 to 5 times a day at 10-15 μs on an extract basis.

When the composition of the present invention is applied to a baldness patient, hair loss becomes significantly reduced after 2 to 3 weeks, and hair loss starts to sprout after 6 to 8 weeks. In addition, although there are some differences depending on the living conditions and constitution of the hair loss patient, when the extracts of dried chestnut leaves, Japanese vinegar and vinewood were applied, the anti-hair loss was almost one month later. It returned to the level of normal people, with an average synergistic effect of about 60%. In addition, when compared to the number of hair growth after 3 months, it was confirmed that the increase of about two times than when the extract of dried chestnut leaves. In addition, seborrheic dermatitis also appeared to be able to see a faster improvement when using the combination extract of the three raw materials. Most importantly, when it was treated only with dried chestnut leaf extract, itching appeared as an improvement in hair loss, but it was shown that itching was greatly alleviated by using an extract containing both vinegar and bark. In addition, it is excellent in alopecia due to hereditary hair loss, which is known to be the most difficult to treat among alopecia, seborrheic and dandruff accompanied by inflammatory diseases such as seborrheic dermatitis and psoriasis.

Hereinafter, the present invention will be described in more detail with reference to specific examples, but the scope of the present invention is not limited by them in any way.

Example 1: Preparation of Combination Extract

1 kg of leaves of Korean native chestnut were harvested and dried in a place where the air was well ventilated. In 30 liters of purified water, 300 g of the native chestnut leaves, 20 g of vineberry fruits and 20 g of vinewood leaves were added and boiled for 3 hours. After 3 hours the fire was turned off and cooled to 50 ℃ to remove the solids. 5 L of purified water was added thereto, and 300 g of the native chestnut leaves, 20 g of vinegar fruit and 20 g of vinewood leaves were added and boiled for 3 hours. By repeating the above procedure four times, a combination extract of dried chestnut leaves, vinegar and bark tree was prepared.

Example 2: Preparation of Hair Regrowth

To the extract prepared in Example 1, methyl paraoxybenzoate was added as an antiseptic to 0.1 wt% based on the total weight of the extract to prepare a hair restorer.

Comparative Example 1: Production of Hair Regrowth

Following the procedure substantially the same as that described in Example 1, except that only the dried chestnut leaves were used without using the vinegar and vinegar leaves, an extract of dried chestnut leaf alone was prepared, and then para A hair restorer was prepared by adding methyl oxyanate at 0.1 wt% based on the total weight of the extract.

Experimental Example 1: Hair Loss Prevention Effect Test

Six men suffering from hereditary alopecia were randomly divided into two groups consisting of three persons each, and the products prepared in Example 2 and Comparative Example 1, respectively, were applied to about 10 to 15 ㏄ once a day. Hair loss prevention effect was evaluated by counting the number of hair loss per day before and after application of the hair restorer. The results are shown in Tables 1a and 1b below.

As shown in the table above, when the dried chestnut leaf, hawthorn and bark tree extracts were applied, they returned to almost normal levels after one month, and about 60% more than when the dried chestnut leaves alone extract was applied. It was confirmed to have an excellent hair loss prevention effect.

Experimental Example 2: Hair growth promoting effect test

Six men suffering from hereditary alopecia were randomly divided into two groups consisting of three persons each, and the products prepared in Example 2 and Comparative Example 1, respectively, were applied to about 10 to 15 ㏄ once a day. Before and after application of the hair regrowth agent, the hair growth rate within 1 cm 2 of the crown was counted to evaluate the hair growth promoting effect. The results are shown in Tables 2a and 2b.

As shown in the table, the number of hair growth after 3 months when the dried chestnut leaves, hawthorn and vinegar combination extracts were applied was confirmed to increase about 2 times compared to the case of applying the dried chestnut leaves alone extract . In addition, the combination extract showed a more rapid effect on seborrheic dermatitis than the extract alone, and in particular, when the dried chestnut leaf alone extract was applied, patients complained of severe itching due to an improvement in hair loss, but the dried chestnut leaf, Itching was not seen in the patients who applied the extracts of the vinegar and vinewood.

Experimental Example 3: Hair Growth and Hair Growth Effect Test

More than 20 males with hair loss due to hereditary hair loss or seborrheic dermatitis were selected and randomly divided into two groups. For each group, the product prepared in Example 2 and Comparative Example 1 was 10 ~ 15 times a day. It was applied to the extent. Before and after the application of the product of Example 2 and Comparative Example 1, and after a certain period of time, the photograph of the hair is shown in Figures 1 and 2, respectively (Fig. 1a to 1c: Product of Comparative Example 1, Figs. Application of Example 2).

From the drawings, it can be seen that when the dried chestnut leaf, vinegar and vinegar combination extract is applied, it has a much better hair growth and hair growth effect than when the dried chestnut leaf extract alone is applied, and any scalp side effects such as edema It could be seen that it does not appear.

According to the present invention, not only exhibits significantly improved hair loss prevention, hair growth and hair growth effects by unexpected synergism between the components extracted from dried chestnut leaves, Japanese vinegar and vinewood, but also itching accompanied by an improvement in hair loss. Can be significantly alleviated. In addition, it is excellent in alopecia due to hereditary hair loss, which is known to be the most difficult to treat among alopecia, seborrheic and dandruff accompanied by inflammatory diseases such as seborrheic dermatitis and psoriasis.

Claims (5)

Iii ) adding 20 g of dried chestnut ( Castanea sp.) Leaves, 20 g of Zanthoxylum schinifolium and 20 g of Zanthoxylum piperitum to 20-40 L of purified water and boiling for 2 to 4 hours; Ii) cooling the boiled product to 40-60 ° C. to remove solids, and then adding 4-6 L of purified water and raw material of step iii) to boil for 2-4 hours; And Iii) repeating step ii) 3 to 5 times: Prepared by the method comprising, hair loss prevention, hair growth or hair growth composition. The composition of claim 1 further comprising a pharmaceutically or cosmetically acceptable carrier selected from the group consisting of surfactants, emulsifiers, thickeners, preservatives, antioxidants, fragrances and mixtures thereof. According to claim 2, hair tonic, hair lotion, hair cream, hair spray, hair mousse, hair gel, hair conditioner, hair shampoo, hair rinse, hair pack, hair treatment, eyebrow regrowth, eyelash regrowth, eyelash nutrition, pet A composition formulated with a shampoo or pet rinse. The composition of claim 1 further comprising a component selected from the group consisting of vitamins, amino acids, animal and vegetable oils, sodium chloride and mixtures thereof. Iii ) adding 20 g of dried chestnut ( Castanea sp.) Leaves, 20 g of Zanthoxylum schinifolium and 20 g of Zanthoxylum piperitum to 20-40 L of purified water and boiling for 2 to 4 hours; Ii) cooling the boiled product to 40-60 ° C. to remove solids, and then adding 4-6 L of purified water and raw material of step iii) to boil for 2-4 hours; And Iii) repeating step ii) 3 to 5 times: A method for producing a composition for preventing hair loss, promoting hair growth or hair growth comprising a.

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