KR20090113955A - Cosmetic compositions for prevention of hair loss or hair restoration containing extracts of fig leaves - Google Patents

Abstract

PURPOSE: A cosmetic composition for hair loss prevention or hair growth promotion containing Ficus Linn leaf extract is provided to suppress testosterone activity and promote hair growth with high safety to the human body. CONSTITUTION: A cosmetic composition for hair loss prevention or hair growth promotion contains 0.5-20.0 weight% of plant extract from Ficus linn leaves. A method for extracting the Ficus linn leaf extract comprises: a step of freeze-drying leaves of Ficus linn then pulverizing; a step of extracting using polar solvent or mixture solvent of the polar solvent and purified water containing ethanol or polyols such as propylene glycol and butylene glycol for 1 to 7 days or using hot water at 40-60°C for 1 to 5 hours.

Description

Cosmetic compositions for preventing hair loss or promoting hair growth containing ficus leaf extract {{Cosmetic compositions for prevention of hair loss or hair restoration containing extracts of fig leaves}

The present invention is a combination of the extract obtained from the fig leaf safe to the human body in the conventional hair composition to inhibit the activity of testosterone, a male hormone, it is not produced by the active testosterone dihydrotestosterone to inhibit hair loss and promote hair growth The present invention relates to a cosmetic composition for preventing hair loss or promoting hair growth, containing an extract of fig tree having an effective effect.

The human hair has about 100,000 to 150,000 hairs, and each hair has a different hair cycle, and the hair is produced, grown, and dropped by repeating the anagen, the catagen, and the telogen. About 15% of the hair is placed in the resting and degenerative stages, so that on average 50-100 hairs fall out and reproduce normally. This hair growth cycle repeats about 3 to 6 years. In general, alopecia refers to a period in which the period of the anagen of the hair cycle is shortened due to various causes, so that the ratio of degenerative and resting hair increases relatively, and the number of hair dropouts is higher than the average value. Although there are genetic androgen hormones, nutritional disorders due to local blood flow disorders, autonomic disorders, autoimmune disorders, and endocrine disorders, there is no clear cause for hair loss until now. It is known to occur by acting.

In recent years, the population that causes abnormal hair loss due to changes in diet, lifestyle changes, and excessive stress caused by social environment is gradually increasing. Especially, the hair loss population of the young, middle-aged and female is increasing. On the other hand, hair loss, which means less or no normal condition due to hair or hair, is distinguished from general hair loss phenomenon (telogen effluvium) in which hair falls out of the resting state and anagen effluvium (abnormal hair loss). In general, the term alopecia refers to the latter. Types of alopecia include alopecia areata, premature alopecia, and alopecia alopecia in women, syphilis alopecia, and male pattern baldness. In male expression, testosterone is involved in male impulse, skeletal muscle increase, male external genital development, scrotum growth, and spermatogenesis, and dehydrotestosterone is involved in acne, sebum increase, hair loss and prostatic hyperplasia. It is known that [J. Invest. Dermatol. (1995) 105 (2): 209-214. Among them, male-type hair loss in male hormone-dependent diseases has serious mental pain for men in the modern society, which focuses on beauty. Therefore, studies are being actively conducted to identify and improve the mechanism of hair loss. Testosterone, a male hormone that is biosynthesized in testes, is a dihydrotestosterone (DHT) that is activated by 5 alpha-reductase, which is present in male hormone-reactive tissues such as sebaceous glands, hair follicles, prostate, or epididymis. As a reductase involved in the conversion, NADPH is known to be used as a coenzyme. Excessive secretion of dihydrotestosterone after puberty acts as a major causative agent in the production of sebum in sebocytes, causing acne and male hair loss. In particular, many hair follicle cells provide a cause for hair loss because dehydrotestosterone binds to hormone receptors better than testosterone. Accordingly, studies are being actively conducted to develop a substance that inhibits the activity and production of 5-alpha-reductase, which promotes the production of dihydrotestosterone, and to use it as a hair regrowth or hair loss prevention agent. Conventionally, female hormones such as estrogen have been used for the treatment of androgenetic alopecia, but female hormones have been reported to cause skin inflammation and side effects due to hormone administration. I'm using it. Recently, Merck of the United States synthesized finasteride (finasteride, proscar), which inhibits the action of 5 alpha-reductase to inhibit the production of dihydrotestosterone, and is commercially available as a hair regrowth for oral administration. If manufactured for direct application and the effect is ineffective and other side effects of oral administration occurs, there is a limit to use. In addition, there is Minoxidil of Upjohn Co., Ltd. disclosed in U.S. Patent No. 4,596,812 as a representative hair growth promoting agent that has been used to promote hair growth. Minoxidil was used as an antihypertensive agent. As a side effect, it is made of hair growth promoter by paying attention to the increase of hair of the human body, and it is a mechanism to promote hair growth by increasing blood flow in the scalp where hair follicles are located. However, when minoxidil is used as a hair growth promoter for a long time, its effect is halved, and as a side effect due to chemical vasodilation, it has been reported that anxiety and sebum increase are reported.

The present invention has been devised in view of the above problems to develop a substance having high human safety even when used for a long time by preventing hair loss or promoting hair growth by inhibiting the production of dihydrotestosterone, which is known to be the main cause of hair loss and masculine hair loss. As a result of repeated studies, the effect of hair loss treatment was good but many side effects occurred. Thus, the person skilled in the art, through the exploration and experiments on the efficacy of many plants in nature, found that the alcohol extract obtained from the fig leaf has an effective effect on hair loss prevention or hair growth promotion. Accordingly, an object of the present invention is to find that the extract extracted from the fig leaf using an alcohol organic solvent has an inhibitory effect of testosterone and ultimately prevents hair loss or promotes hair growth by preventing it from being produced as the active male hormone dihydrotestosterone. It is to provide a composition having an effect. Thus, by containing this plant extract in a conventional hair composition to develop a composition having an effective effect on hair loss prevention and hair growth promotion, it will be described in detail with an embodiment of the present invention as follows.

The present invention provides a dried medicinal herb in the form of a dry medicinal herb for the long-term use, while having an effective effect on inhibiting hair loss and promoting hair growth by inhibiting the production of the active male hormone dihydrotestosterone. The extract obtained by extraction with an alcohol solvent is composed of a certain amount according to the formulation of the cosmetic composition for preventing hair loss or promoting hair growth.

Referring to the contents related to the present invention of the fig (tree) leaves used in the present invention are as follows.

Fig is a plant belonging to the genus Ficus Linn of Moraceae. It is known that there are about 600 kinds of plants of the fig family, and there are some forms of semi-frozen survival on shrubs and rocks, but most of them are only subtropical figs grown as tropical evergreens or fruit trees used for ornamental or timber. They all have something in common that produces milky sap. The fig is native to Carica in Asia Minor, and is named after its name (Ficus carica). The Capri, considered to be the ancestor of cultivated species, is wild in Southwest Asia (Arabia) and is known to be wild in all coastal Mediterranean countries, such as Eastern Perugia (Iran), Syria and Afghanistan. The name Capri is thought to have been named after the island of Capri, south of the port of Naples, in Italy, where fig cultivation has long since taken place. Figs are horticulturally classified according to the type of flower and the need for pollination. They are classified into four species: capri, smyrna, common, and san pedro. The process of differentiation is already cultivated since BC 4 ~ AD 37. It is known that the high quality varieties are already being grown in Europe. Fig leaves are alternate, broad egg-shaped. In spring and summer, axillary inflorescence develops in the axilla and many small flowers run in it. Fruits are dark purple silver (화 花果), ripen in autumn and used for food. Leaves contain protein, rubber, etc., the milk (乳汁) as a remedy for roundworms or neuralgia. Figs have long been valued in the Bible and in agreements as folk medicines. The utility is said to be good for blood pressure strengthening, health, nutrition, constipation, hepatitis, cancer, women's disease vitality recovery. Herbal gangmok (myeong) "Smooth the action of the bones to stop diarrhea and sore throat," the effect is described. Jinnam honcho (personal name) "Aka Myeong-Gwa," Orser, should be washed frequently with the juice of the rind, and the taste will emulsify the throat to open the cerebral chest, enter the liver to improve blood flow and clear the eyes. " This is described. General efficacy, gastrointestinal action, diarrhea or hemorrhoids treatment, sore throat, anti-inflammatory action, small-acting action, and promote digestion, etc. are also used for pesticides and jaundice. In animal experiments, it is reported that milk contained in fruits of immature fever was effective for cancer, leukemia and imperiosarcoma. Fig is a natural health food that is resistant to pests, grows young sprouts cleanly, and grows in pollution-free nature without pesticides. Neuralgia and rheumatism are mixed with 10 pieces of fig leaves and a bucket of garlic, put them in a pot and boil, then put the affected part in a foreign body, cool it to the end, and soak the affected part for 20 minutes and steam it. It is better to apply

The fig tree used in the present invention is dried, finely pulverized and extracted after the leaves of the conventional lyophilization method. The extraction solvent used to prepare the plant extract used in the present invention is ethanol or a polar solvent in which a small amount of polyols such as propylene glycol, butylene glycol is added thereto, or a mixed solution of them and purified water. It is possible to use a conventional method as the extraction method, for example, by adding 5 to 10 times the amount of the above extraction solvent to the dried fig leaf powder, immersion extraction at room temperature for 1 to 7 days or at 40 to 60 ℃ under 1 atmosphere The extract is obtained by heating for 1 to 5 hours.

In the present invention, when the cosmetic composition for preventing hair loss or promoting hair growth is applied to the scalp, the amount of the fig leaf extract in the scalp cosmetic is preferably 0.05 to 50.0% by weight, particularly 0.5 to 20.0% by weight.

Meanwhile, the cosmetic composition for preventing hair loss or promoting hair growth containing the fig leaf extract of the present invention may be used as an ointment, cream, lotion, liquid, spray, etc. when used for the purpose of preventing hair loss or promoting hair growth. It can be used in various formulations. The cosmetic composition of the present invention is preferably formulated into topical application preparations, such as ointments, lotions, sprays, and the like, and applied directly to the hair loss site. The composition of the present invention may also further include one or more known herbal ingredients that may enhance the hair growth effect as needed. Plant components that may be included for this purpose include, for example, extracts or oils extracted from whites, whites, red ginseng, licorice, cloves, safflower, dermis, cheongho, green tea, dried branches, dermis, flaxseed, pomegranate, cornus and wolfberry. There is this. When such additional components are included in the composition of the present invention, their content is preferably within 5% based on the total weight of the composition. In addition, the hair growth promoting cosmetic composition of the present invention includes an antibacterial hair composition and a composition for the scalp. The hair growth promoting composition may include a conventional compounding ingredients hinokithiol, pepper tink, tocopherol acetate, nico acid amide nicotinic acid benzine, pyroxtonolamine, salicylic acid, L- menthol, shampoo, hair conditioner, hair lotion, All formulations that can be applied to the scalp, such as liquid hair growth promoter type, are possible. The cosmetic composition for hair may include alpha hydroxy acid (α-Hydroxy acid), beta hydroxy acid (β-Hydroxy acid), fragrances, colorants, fungicides, antioxidants, preservatives, moisturizers, etc., shampoo as a cosmetic or cleaning agent Formulations of soap, cream, and the like are possible. The present invention is described in more detail by the following examples and experimental examples, but the present invention is not limited in any way by these.

 Referring to the method of producing a fig leaf extract of the present invention in detail through Example 1.

<Preparation Example 1>-Manufacturing method of fig leaf extract according to the present invention

400 g of pulverized leaves (dry medicinal herb) was added to 3,000 ml of ethanol, and the mixture was immersed at room temperature for 10 days, extracted and filtered. The filtrate was evaporated under reduced pressure and evaporated to obtain 26 g of concentrate.

In addition, the liquid hair growth promoting or hair loss preventing composition containing the fig tree leaf extract of the present invention is shown in Formulations 1 and 2 below by the solubilization method using the fig tree leaf extract according to Preparation Example 1 and other auxiliary ingredients. It was prepared at the composition ratio, with the control composition was also prepared.

<Formulation Example 1>-Cosmetic liquid composition for promoting hair growth

    Name  Content (% by weight) Prescription Example 1 Prescription Example 2 Prescription Example 3 Prescription Example 4 Prescription 1 Extract of Preparation Example 1 Cornus milk extract Pepper tin Ginseng extract Tocopherol acetate Salicylic acid L-menthol POE sorbitan fatty acid ester flavoring preservative  1.0-----0.1 0.3 Correct Volume to 100 0.1-----0.1 0.3 appropriate quantity to 100 5.0-----0.1 0.3 Correct Volume to 100 5.0 1.0 0.5 1.0 1.0 0.15 0.1 0.3 Proper quantity to 100 -1.0 0.5 1.0 1.0 0.15 0.1 0.3 Correct Volume to 100

       <Formulation Example 2>-Liquid composition for preventing hair loss

   Name Content (% by weight) Prescription Example 1 Prescription Example 2 Prescription Example 3 Prescription Example 4 Prescription 2 Extract of Preparation Example 1 Cornus milk extract Pepper tin Ginseng extract Tocopherol acetate Salicylic acid L-menthol POE sorbitan fatty acid ester flavoring preservative  1.0-----0.1 0.3 Correct Volume to 100 0.1-----0.1 0.3 appropriate quantity to 100 5.0-----0.1 0.3 Correct Volume to 100 5.0 0.5 0.5 0.5 0.5 0.15 0.1 0.3 Proper amount to 100 -0.5 0.5 0.5 0.5 0.15 0.1 0.3 appropriate quantity to 100

The effect on hair growth promotion of the anti-hair loss or hair growth promoting cosmetic composition containing the fig leaf extract according to the present invention as described above was measured.

Test Example 1 Measurement of Sebum Production in Cells Promoted by Testosterone

Ficus leaf extracts were observed to inhibit sebum production in the scalp by using SZ95 human sebaseous gland cell line, which is characterized by primary human sebocytes whose function was enhanced by testosterone, a male hormone, and overproduction by testosterone. The anti-androgenic effect of Ficus leaf extract on sebum was observed. That is, 1 × 10 ⁵ SZ95 cells were dispensed in 10 cm culture vessels, and testosterone (10 ⁻⁶ M) and ficus leaf extract were incubated at 100 μg / ml and 200 μg / ml for 5 days, and then total As a result of quantifying sebum production, the total amount of the control group was 25.54 ± 0.2mg / ml, and the testosterone treatment group was 37.37 ± 0.4mg / ml. However, the testosterone and fig leaf extracts showed 25.32 ± 0.2mg / ml and 22.92 ± 0.1mg / ml, respectively, in the 100 ㎍ / ml and 200 ㎍ / ml treated groups, which were significantly decreased compared to the testosterone treated group. It is explained by the reduction of fat and the like. This suggests that the fig leaf extract significantly inhibits the activity of testosterone (see graph below).

Test Example 2 Measurement of Hair Growth Promoting Effect Using Animals

 First, the cosmetic composition for promoting hair growth containing the fig leaf extract according to the present invention and the composition of the conventional prescription (control) were prepared in the liquid phase as in the case of Formulation Example 1, and the effect was measured using an animal. To this end, hair from the back of 42-56 days old mouse (C57BL / 6, male) was removed, and 10 tablets of each of the back of the formulation of Formulation Example 2 and Control Formulation 1 of Formulation Example 2 were placed on the back 1 day 1 100 μl was applied for 28 days. The results were compared by calculating the rate at which new hairs were grown with respect to the area from which hair was removed by using an image analyzer, and when the ratio was 70% or more, it was judged that the hair growth promoting effect was obtained. .

Table 1 Hair growth promoting effect-Formulation Example 1

Formulation Example 1 Prescription Example 1 Prescription Example 2 Prescription Example 3 Prescription Example 4 Prescription 1 Formulation Example 1 75.3 72.6 82.9 88.4 40.5

As a result of the above, the composition of Formulation Examples 1 to 4 containing the fig leaf extract showed a hair growth promoting effect almost 2 times higher than that of the control formulation 1. Inclusion of auxiliary components showed a higher hair growth promoting effect than otherwise.

<Test Example 3> Clinical measurement of the hair loss prevention effect

In order to confirm the hair growth promoting effect shown in the animal experiment confirmed in Test Example 2 in the clinical use by humans, a subject with alopecia was selected and the clinical effect of hair loss prevention was measured. In other words, a clinical trial of hair growth promotion was conducted using Formulation Examples 1 to 4 of Formulation Example 2 containing Fig leaf extract and Control Formulation 2, which does not contain the extract. Ten adults with alopecia male alopecia aged 30 to 50 years or those with an average daily hair loss of 100 or more were selected. The method of use was to apply about 2ml about 2 ~ 3 times a day to the hair loss site, and it was used for at least 1 month and up to 3 months depending on the degree of effect confirmation, and more than that was not effective. To determine the effect, the average daily hair loss at trituration, gross findings, and improvement in subjective symptom improvement were evaluated in five stages according to the following Table 2, and overall improvement was taken as the average of the evaluation scales. The final judgment was that the overall improvement was 3.0 points or more, and the results are shown in Table 3 below.

<Table 2> Measures for Measuring Hair Loss Prevention Effect

Phase division One 2 3 4 5 Visual Determination of Hair Loss at Tribal worse immutability Light reduction decrease A marked decrease

Table 3 Anti-Hair Loss Effect-Formulation Example 2

Phase division Tricycle Daily hair loss Subjective symptoms Visual judgment Comprehensive Improvement Diagram Prescription Example 4 4.1 4.3 4.0 4.4 4.2 A control prescription 1.3 2.6 2.5 2.4 2.2

As described above, the composition of Formulation Example 4 of Fig. 2 containing the fig leaf extract showed a significant hair loss improvement effect compared to the composition of Control Formula 2, and no adverse effects were found in all subjects during the use period. It was found that the composition is safe for the human body. Through the above Test Examples 1 to 3, the fig leaf extract strongly inhibits the activity of testosterone and inhibits the growth of dihydrotestosterone, thereby promoting hair growth and preventing hair loss of the composition containing the same as compared to the case without it. I could see the superiority.

As described through the preparation and test examples above, the present invention not only revealed that the extract extracted from the fig tree leaf has the effect of preventing hair loss by inhibiting the process of converting testosterone to dihydrotestosterone, and particularly containing the same. By preparing a composition for preventing hair loss or promoting hair growth, there is an excellent effect of effectively treating and preventing male hair loss. In conclusion, as a result of clinically measuring the effect of the composition according to the present invention, the cosmetic composition for preventing hair loss or promoting hair growth containing the fig leaf extract to prevent male hair loss or promote hair growth as compared to the conventional similar composition Has an excellent effect.

Claims (2)

Hair loss prevention or hair growth cosmetic composition containing a fig leaf extract characterized in that it contains 0.5 to 20.0% by weight of the plant extract extracted from the leaves of the fig tree in the conventional hair loss prevention or hair growth promoting composition. According to claim 1, wherein the cosmetic composition is a fig, characterized in that it has a cosmetic formulation, such as shampoo, rinse, hair gel, hair mousse, hair spray, hair tonic, hair essence, hair liquid, hair treatment cream, hair pack Hair loss prevention or hair growth cosmetic composition containing a tree leaf extract.