KR20100116386A - Composition for hair growth - Google Patents

Abstract

PURPOSE: A composition for hair growth which is able to use for a long time without side effects is provided. CONSTITUTION: A composition for hair growth contains Chrysanthemi sibirici Herba extract, tocopherol acetate, salicylic acid, dipantenol, niacin amide, biotin, pentadecane glyceride, climbazole, ecliptae Herba extracts, thujae Semen extracts, extract of Sophora flavescenes, extract of eugenia caryophyllata, ginger extract, birch extract, green tea extract, polygonum multiflorum Thunberg extracts, extracts of schisandra chinensis, persicae Semen extracts, perillae Folium extract, peony extract, and paeoniae Radix rubra extracts. The composition contains 0.0001-50 weight parts of Chrysanthemi sibirici Herba extract based on 100 weight parts. The Chrysanthemi sibirici Herba is Chrysanthemum zawadskii or Chrysanthemum indicum. The Chrysanthemi sibirici Herba extract is an organic solvent extract, water extract or supercritical extract.

Description

Hair growth and hair growth composition {composition for hair growth}

The present invention relates to a hair growth and hair growth composition, specifically, by adding one or more components, for example, tocopherol acetate, salicylic acid or nasturtium extract, etc., which can increase the hair growth and hair growth effects of gujeolcho extract to gujeolcho extract The present invention relates to a hair growth and hair growth composition that is safe and has no side effects, and has excellent hair growth and hair growth effects.

Hair is maintained by repeating hair growth and hair loss in cycles of anagen, catagen, and telogen. Specifically, anagen, which grows hair, catagen, which is the end of growth and shrinking of the hair follicles, talogen, which is the time when the nipple stops working and the hair stays in the scalp. It can be divided into a generator, which is a time to start or to dehair old hair by generating new hair. Hair loss is a normal phenomenon, but in normal people a lot of hair growth phase hair loss (alopecia) people have a lot of hair at rest is a visible hair loss phenomenon.

The types of androgenetic alopecia include male pattern alopecia and female pattern hair loss.

Androgenetic alopecia is caused by a testosterone testosterone. When testosterone is turned into a more potent hormone, dihydrotestosterone (DHT) by an enzyme called alpha-reductase, Hydrotestosterone acts on the hair follicles, leading to hair follicles from the growth phase to the degenerative phase, leading to hair loss. Therefore, in order to treat alopecia caused by this cause, a method of inhibiting the production of DHT by 5 alpha-reductase is mainly used.

Gynecologic alopecia is mainly caused by a decrease in the amount of estrogen after menopause. Female alopecia, unlike the appearance of male alopecia, does not fall out of the front of the head, only the hair in the middle part is mainly lost. Alopecia in women has a lower association with 5 alpha-reductase than men. Thus, drugs that inhibit 5 alpha-reductase have little effect on post-menopausal alopecia women. Minoxidil or estrogen is mainly used as a treatment for such alopecia.

In addition to androgenetic alopecia, there are alopecia areata and other causes of alopecia. Alopecia areata is caused by autoimmune diseases, mental stress, or genetic predisposition. Hair loss of round or oval shape occurs, and it is characterized by ringworm whitening or hair growth wall. These alopecia areata are fundamentally different from those of male hormonal alopecia, and different methods are used to treat corticosteroids, or minoxidil is applied to the affected part or artificially induced to the affected part.

Against these diverse and complex causes of hair loss, commercially available hair loss prevention products are active ingredients that contain ingredients aimed at promoting blood circulation, inhibiting the action of testosterone, and strengthening the hair root function. It is absent and problems of side effects are raised.

Currently used hair regrowth agents include minoxidil of US Pat. No. 3,382,247 approved by the US Food and Drug Administration (FDA) as a raw material for hair regrowth and finasteride mentioned in US Pat. There is this. However, minoxidil has been reported to cause sticky feeling and irritation to the skin, and finasteride has been reported to have side effects such as sexual dysfunction, and it is effective only when a steady dose is taken for hair loss, including 5 Alpha-reductase activity inhibitors are difficult to expect the effect by application, and can be expected only by oral administration, there is a lot of inconvenience in use.

An object of the present invention to solve the above problems is to provide a hair growth and hair growth composition excellent in the hair growth effect, including a plant extract as a main component, safe to the human body without side effects.

The present invention to achieve the above object,

Gujeolcho extract; And

Tocopherol Acetate, Salicylic Acid, Dipanthenol, Nicotinamide, Biotin, Pentadecaneglycerides, Hinocthiol, Zinc Pyrithione, Climbazole, Nasturtium Extract, White Porcelain Extract, Red Ginseng Extract, Clove Extract, Ginger Extract, Birch Extract, Green Tea Extract, There is provided a hair growth and hair growth composition comprising alone or in a mixture thereof selected from the group consisting of a mushroom extract, a mushroom extract, an Omija extract, a Toin extract, a lobule extract, a peony extract, an apple extract, a fennel extract, .

The Gujeolcho extract may be included in an amount of 0.0001 to 50 parts by weight based on 100 parts by weight of the total composition.

Tocopherol acetate, salicylic acid, dipanthenol, nicotinic acid amide, biotin, pentadecaneglycerides, hinokithiol, zinc pyrithione, climbazole, nasturtium extract, white porcelain extract, red ginseng extract, cloves extract, ginger extract, birch extract, green tea extract , Yiyiin extract, red sesame extract, schisandra extract, cauliflower extract, leaflet extract, peony extract, red peony extract, fennel extract, pine needle extract and pine needle extract selected alone or a mixture thereof based on 100 parts by weight of the total composition 0.001 to 10 parts by weight may be included.

The gujeolcho extract may be an organic solvent extract, water extract or supercritical extract.

The hair growth and hair growth composition of the present invention includes Gujeolcho extract, which is a plant extract as a main component, safe for human body and has no irritation to the scalp even when used for a long time, and has no side effects.

Gujeolcho extract of the present invention is excellent in the hair growth and hair growth effect because it promotes hair growth by shortening the period of transition from the resting phase to the growth phase of the hair cycle. In addition, the composition of the present invention further comprises a component that can increase the hair growth and hair growth effect of Gujeolcho extract is superior to the conventional hair growth and hair growth effect.

Hereinafter, the present invention will be described in detail so that those skilled in the art can easily practice.

The present invention Gujeolcho extract; And tocopherol acetate, salicylic acid, dipanthenol, nicotinamide, biotin, pentadecaneglycerides, hinokthiol, zinc pyrithione, climbazole, nasturtium extract, white porcelain extract, red ginseng extract, cloves extract, ginger extract, birch extract, green tea A hair growth and hair growth composition comprising a single component or a mixture thereof selected from the group consisting of an extract, a natural extract, a red seaweed extract, an omija extract, a doense extract, a lobule extract, a peony extract, an apple extract, a fennel extract, to provide. The hair growth and hair growth composition of the present invention further increases the hair growth and hair growth effect by including one or more additional ingredients that can further increase the hair growth and hair growth effect when used in combination with the Gujeolcho extract in addition to the Gujeolcho extract.

In the present invention, the gujeolcho serves to make the hair grow at a rapid rate by shortening the period of transition from the resting phase to the growth phase of the hair growth cycle. The gujeolcho is a representative of the blooming in the fall in May Dano in 5 stems, and the lunar calendar on September 9 is called 9 gujeolcho (九 節 草) is called. In addition, Gujeolcho has a single flower at the end of the stem, which is called Seonmocho because white flowers stand out more than fresh. The Gujeolcho is native to the whole country except the beach and grows in a colony, especially in high and deep mountains. In Chinese medicine, gujeolcho is mainly used to treat menstrual disorders, cold of the uterus, infertility and indigestion.

The gujeolcho may be used without limitation varieties known in the art, preferably, Chrysanthemum zawadskii , or Chrysanthemum indicum may be used. The Wonjeolcho or furniture cutting vinegar is superior to the hair growth and hair growth effect than Gujeolcho of other varieties. The gujeolcho is one of the varieties of gujeolcho is also called broad leaf gujeolcho, because of its beautiful shape is also cultivated for ornamental purposes. Compared to Wonjeolcho, the furniture cuts are smaller in leaf and fragrance. The furniture cuttings help the blood of the eye, stop tearing, and keep the head and eyes cool. In addition, the antipyretic effect is great, it is known to be good for pneumonia, bronchitis.

The gujeolcho extract can be obtained by extracting various organs or parts of gujeolcho, that is, leaves, flowers, fruits, stems, roots, branches and bark. The Gujeolcho extract may include all extracts of Gujeolcho obtained by conventional extraction methods known in the art, such as organic solvent extract, water extract extracted using water, supercritical extract. Preferably it may be an organic solvent extract. The organic solvent can be used without limitation those known in the art, specifically, lower alcohols such as methanol, ethanol, isopropyl alcohol, butanol; Polyhydric alcohols such as glycerol, ethylene glycol, propylene glycol and 1, 3-butylene glycol; And hydrocarbon solvents such as petroleum ether, methyl acetate, ethyl acetate, benzene, hexane, methylene chloride, diethyl ether, dichloromethane, chloroform, and the like, or a mixture thereof.

The Gujeolcho extract may be included in an amount of 0.0001 to 50 parts by weight based on 100 parts by weight of the total composition. Preferably it may be included in 0.01 to 10.0 parts by weight. If it is contained less than 0.0001 parts by weight, hair growth induction promoting effect does not appear, and if it is added in excess of 50 parts by weight, dissolution in the composition of Gujeolcho extract is difficult, so it is not easy to formulate. It is not preferable because the discomfort is large compared to the effect.

The hair growth and hair growth composition of the present invention is in addition to gujeolcho extract, tocopherol acetate, salicylic acid, dipanthenol, nicotinic acid amide, biotin, pentadecaneglycerides, hinokthiol, zinc pyrithione, climbazole, nasturtium extract, white porcelain extract, ginseng extract, clove extract , Ginger extract, birch extract, green tea extract, winsin extract, red mulberry extract, omija extract, doin extract, lobule extract, peony extract, peony extract, fennel extract, pine leaf extract and extract It further comprises a mixture. The components serve to increase the hair growth and hair growth effect of Gujeolcho extract. In addition, the above-mentioned tocopherol acetate, salicylic acid, di-panthenol, nicotinamide, biotin, pentadecane glyceride, hinokitiol, zinc pyrichion, and climbazole can also moisturize and nourish the hair.

The nasturtium extract, white porcelain extract, red ginseng extract, cloves extract, ginger extract, birch extract, green tea extract, uiyiin extract, red sesame extract, Schisandra extract, cabbage extract, leaflet extract, peony extract, red peony extract, fennel extract, pine needle extract Or plant extracts such as pine needle extract can be obtained using any extraction method known in the art without limitation.

Tocopherol acetate, salicylic acid, dipanthenol, nicotinic acid amide, biotin, pentadecaneglycerides, hinokithiol, zinc pyrithione, climbazole, nasturtium extract, white porcelain extract, red ginseng extract, cloves extract, ginger extract, birch extract, green tea extract , Yiyiin extract, red sesame extract, Schizandrae extract, cauliflower extract, leaflet extract, peony extract, red peony extract, fennel extract, pine needle extract and pine needle extract alone or a mixture thereof is 0.001 parts by weight of the total composition To 10 parts by weight. If it is included less than 0.001 parts by weight, the effect of increasing the hair growth and hair growth effect is insignificant, and when added in excess of 10 parts by weight may be irritating to the scalp.

The composition of the present invention may include auxiliary ingredients conventionally used in the art for providing additional functions in addition to the above components. For example, auxiliary ingredients such as anti-dandruff, hair root enhancer, hair repair agent, scalp protector, and refreshing agent may be included. The auxiliary ingredient may be formulated in an appropriate ratio by those skilled in the art without departing from the object of the present invention.

The hair growth and hair growth promoting composition of the present invention can be formulated in various shapes known in the art, for example, applied to the scalp, such as external preparations, creams, ointments, pastes, aerosols, gels, waxes and the like. It can be formulated into topical scalp and softening lotion, nourishing lotion, nourishing cream, massage cream, essence, pack, shampoo, rinse, ampoule and treatment.

Hereinafter, the present invention will be described in more detail with reference to Examples and Comparative Examples. However, the following Examples and Comparative Examples are only examples, but are not limited thereto.

Example 1 Preparation of Gujeolcho Extract

After cutting the stems and leaves of Wonjeolcho and filtering impurities, 400-1500ml of ethanol and purified water were added to 100g of Gujeolcho and chilled at room temperature for 5 days. The extracted stock solution was filtered using Whatman # 3 filter paper, and the filtered extract was evaporated completely at 45 ° C. using a vacuum concentrator to obtain a dried extract.

Example 2 Preparation of Plant Extract

In the same manner as in the preparation of the Rhizoma extract of Example 1, the extracts of Tricholoma matsutake, Baekjain extract, Gossam extract, Clove extract, Ginger extract, Birch tree extract, Green tea extract, Wuin extract, Red seaweed extract, Omiza extract, , Peony Extract, Peony Extract, Fennel Extract, Pine Needle Extract and Pine Needle Extract were obtained.

< Example  3 to 28>

To hair growth and hair growth composition was prepared in the same composition as in Tables 1 to 3. Gujeolcho extract of the following table is Gujeolcho extract prepared in Example 1. The units in the table below are parts by weight.

Example ingredient 3 4 5 6 7 8 9 10 11 ethanol 40 40 40 40 30 40 40 40 40 1,3-butylene glycol 10 10 10 10 10 10 10 10 10 Gujeolcho Extract 5 5 5 5 5 5 5 5 5 Tocopherol Acetate One Salicylic acid One Difanthenol One Nicotinic acid amide One Biotin One Pentadecaneglycerides One Hinoki Thiol One Zinc pyrithione One Creambazole One Purified water Remnant Residual amount Residual amount Residual amount Residual amount Residual amount Residual amount Residual amount Residual amount

Example ingredient 12 13 14 15 16 17 18 19 20 21 22 23 ethanol 40 40 40 40 30 40 40 40 40 40 40 40 1,3-butylene glycol 10 10 10 10 10 10 10 10 10 10 10 10 Gujeolcho Extract 5 5 5 5 5 5 5 5 5 5 5 5 Hanchuncho extract One White porcelain extract One Ginseng extract One Clove Extract One Ginger extract One Birch Extract One Green tea extract One Wii extract One Red Snail Extract One Omi Tea Extract One Doin Extract One Leaflet extract One Purified water Jangrang Balance Balance Balance Balance Balance Balance Balance Balance Balance Balance Balance

Example ingredient 24 25 26 27 28 ethanol 40 40 40 40 40 1,3-butylene glycol 10 10 10 10 10 Gujeolcho Extract 5 5 5 5 5 Peony extract One An effective drug extract One Fennel extract One Pine Needle Extract One Pine Needle Extract One Purified water Jangrang Balance Balance Balance Balance

< Example  29 to 34> Manufacture of shampoo

To prepare a shampoo comprising the components of the hair growth and hair growth composition of the present invention in the composition of Table 4. The units in the table below are parts by weight.

Ingredient Example 29 Example 30 Example 31 Example 32 Example 33 Example 34 Sodium Lauryl Sulfate 10 10 10 10 10 10 Cocamidopropyl Betaine 3 3 3 3 Carboxyl Vinyl Polymer 0.3 0.3 0.3 0.3 0.3 0.3 Polyquaternium-10 0.2 0.2 0.2 0.2 0.2 0.2 incense 0.7 0.7 0.7 0.7 0.7 0.7 Methyl paraben 0.2 0.2 0.2 0.2 0.2 0.2 Cetyltrimethylammonium
Chloride 0.1 0.1 0.1 0.1 0.1 0.1 Tocopherol Acetate 0.1 - - 0.5 One 0.3 Salicylic acid 0.1 - - 0.1 0.5 0.1 Biotin - 0.01 0.02 - - - Climbazole 0.1 0.1 - - - - Zinc pyrithione - 0.5 - - - Nicotinic acid amide 0.2 - - - - - Gujeolcho Extract 5 5 5 5 3 One Nasturtium Extract One One One - - - Purified water Residual amount Residual amount Residual amount Residual amount Residual amount Residual amount

< Example  35 to 38> preparation of rinse

To prepare a rinse comprising the components of the hair growth and hair growth composition of the present invention in the composition of Table 5. The units in the table below are parts by weight.

Ingredient Example 35 Example 36 Example 37 Example 38 Cetyl alcohol 2 2 2 2 Stearyl alcohol 2.5 2.5 2.5 2.5 Behenyl Alcohol 0.5 0.5 0.5 0.5 Spices 0.4 0.4 0.4 0.4 Silicone emulsion 0.4 0.4 0.4 0.4 Cyclomethicone 1.0 1.0 1.0 1.0 Dimethyl distearyl ammonium chloride 0.1 0.1 0.1 0.1 Citric acid to pH 3 ~ 7
Adjustable amount to pH 3 ~ 7
Adjustable amount to pH 3 ~ 7
Adjustable amount to pH 3 ~ 7
Adjustable amount Difanthenol 0.1 - - - Tocopherol Acetate 0.1 0.1 0.5 0.3 Salicylic acid - - 0.3 0.1 Climbazole 0.2 0.2 - - Gujeolcho Extract 5 5 5 3 Ginger Extract One One - - Purified water Residual amount Residual amount Residual amount Residual amount

< Example  39 to 40> preparation of ampoules

Ampoules containing the components of the hair growth and hair growth compositions of the present invention were prepared with the compositions of Table 6 below. The units in the table below are parts by weight.

Ingredient Example 39 Example 40 ethanol 30 30 Propylene glycol 20 20 1.3-butylene glycol 10 10 Cetyltrimethylammonium
Chloride 3 3 Dimethyl distearyl ammonium chloride 0.1 0.1 Lauryl Alcohol 3 3 Myristyl Alcohol 5 5 Cetyl alcohol One One incense 0.5 0.5 dyes A reasonable amount A reasonable amount Tocopherol Acetate 0.1 0.1 Salicylic acid - 0.1 Biotin 0.01 - Gujeolcho Extract 5 2 Pine Needle Extract One - Purified water Residual amount Residual amount

< Example  41> Tonic  Produce

Ampoules were prepared comprising the components of the hair growth and hair growth composition of the present invention with the composition of Table 7 below. The units in the table below are parts by weight.

Manufacturing Component (% by weight) Example 41 ethanol 40 Propylene glycol 10 Polysorbate 20 5 incense 0.5 dyes A reasonable amount Tocopherol Acetate 0.3 Salicylic acid 0.1 Gujeolcho Extract 3 Purified water Residual amount

< Comparative example  1 to 3

Hair growth and hair growth compositions were prepared according to the composition shown in Table 8 below. The citrus extracts of Table 8 below are the citrus extracts prepared in Example 1. The units in the table below are parts by weight.

Comparative Example ingredient One 2 3 ethanol 40 40 40 1,3-butylene glycol 10 10 10 Gujeolcho Extract - 5 - Tocopherol Acetate - - 0.5 Salicylic acid - - 0.2 Purified water Jangrang Balance Balance

< Experimental Example  1> mouse C57BL Of 6  Used in vivo Hair growth  exam

Experimental methods mainly used to study hair growth and hair growth effects include in vivo evaluation using experimental animals and in vitro evaluation using tissue culture of dermal papilla cells. The research and evaluation methods related to hair growth and hair growth by using the hair are being actively conducted.

In the present invention, the hair growth and hair growth compositions obtained in Examples 3 to 28 and Comparative Examples 1 to 3 were obtained using In C57BL / 6. vivo Hair growth test was carried out. C57BL / 6 mice are group hairy degenerated from 6 weeks after birth, in vivo animal models most commonly used for the purpose of hair growth test in mice with the characteristic cycle back to return to growth when the 12-week-old were to off-season from 7-week-old to be. Six-week-old mouse C57BL / 6 females were purchased with subjects weighing within three days of the same day of birth (DOB). Experiments were carried out at 7 weeks of age with adaptation for 1 week at 25 ° C and 50% humidity. The mouse was placed in a desiccator containing ether and anesthetized for 1 minute, and then the hair of the mouse was removed using a hair remover. After 1 day, a sample was applied to the mice with no back wounds. 100 μl of the samples were applied once a day, and photographed after 30 days of application. Table 9 shows the results of the degree of hair growth of Examples and Comparative Examples based on the degree of hair growth of the hair growth and hair growth composition containing 5 parts by weight of minoxidil.

division Hair growth degree (%) Minoxidil 100 Example 3 95 Example 4 85 Example 5 89 Example 6 91 Example 7 101 Example 8 87 Example 9 83 Example 10 84 Example 11 88 Example 12 99 Example 13 90 Example 14 88 Example 15 89 Example 16 92 Example 17 90 Example 18 93 Example 19 85 Example 20 84 Example 21 83 Example 22 85 Example 23 86 Example 24 87 Example 25 88 Example 26 89 Example 27 94 Example 28 98 Comparative Example 1 0 Comparative Example 2 80 Comparative Example 3 0

According to Table 9, the hair growth and hair growth composition of Example was not significantly superior to the hair growth and hair growth effect than minoxidil commercialized as a hair growth agent, but showed a hair growth and hair growth effect that is generally close to minoxidil. Therefore, the hair growth and hair growth composition of the present invention is expected to be able to replace minoxidil because it has the same effect as minoxidil and contains plant extract as a main component and is safe for human body and has less side effects.

Experimental Example 2 Evaluation of Activity of Hair Follicle Cells

Cell lines were obtained from human dermal papilla cells purchased from SCIENCELL. Cell culture was incubated in a 5% CO ₂ incubator using Mesenchymal Cell Medium.

MTT assay was performed to determine the effect of promoting growth of dermal papilla cells of the hair growth and hair growth compositions of Examples and Comparative Examples. MTT assay was performed in the following manner. First, human dermal papilla cells pre-cultured in 100 dishes were removed using trypsin, and the cells were counted using a hemochromometer (Hemacytometer) and adjusted to 10 ⁵ cell / ml. 100 μl of the dermal papilla cell solution (10 ⁴ cells per Well) was put into a 96 well plate and incubated for 1 day. After diluting the hair growth and hair growth composition samples prepared in Examples 3 to 28 and Comparative Examples 1 to 3 to 2% in the mesenchymal cell medium, each sample was added to 96 wells containing cells cultured for 1 day. The first stage concentration of the sample was brought to 1%. 100 µl of the 96 well sample solution was diluted by 1/2 to dilute to 18 wells per sample so that the treatment concentration of the hair growth and hair growth compositions of the Examples and Comparative Examples was 0.001%. 96 wells of the samples were incubated for 1 day at 37 ° C. and 5% CO ₂ , followed by 0.1 mg (20 μl of 5 mg / ml) of MTT (3- (4,5-dimethylthiazol-2-yl) -2, 5-diphenyl-tetrazolium bromide) solution was added to all wells. After incubating for 4 hours at 37 ° C., the plate was centrifuged at 1000 rpm for 5 minutes and then all of the medium was removed. 200 μl of DMSO was added to each well to allow the resulting formazan salt to dissolve completely. After measuring the absorbance at 570 nm with a microplate reader, the degree of growth of the dermal papilla cells was determined. The results are shown in Table 10 below. The value of the following Table 11 shows the result of obtaining the mean OD ₅₇₀ value of each well column calculating the percentage value of the average OD ₅₇₀ value of the control group. The control means a group treated with the hair growth and hair growth composition of Comparative Example 1 that does not contain the active ingredient of the present invention.

division Hair growth degree (%) Minoxidil 136 Example 3 132 Example 4 128 Example 5 129 Example 6 130 Example 7 138 Example 8 127 Example 9 128 Example 10 128 Example 11 130 Example 12 138 Example 13 131 Example 14 127 Example 15 129 Example 16 134 Example 17 133 Example 18 130 Example 19 127 Example 20 131 Example 21 128 Example 22 129 Example 23 128 Example 24 126 Example 25 126 Example 26 127 Example 27 135 Example 28 137 Comparative Example 1 100 Comparative Example 2 125 Comparative Example 3 105

According to Table 10, the hair growth and hair growth compositions of Examples are shown to activate the growth of both dermal papilla cells compared to the comparative example. In other words, the hair growth and hair growth compositions of the Examples are expected to promote hair growth because they activate the growth of dermal papilla cells. In addition, the composition of Examples 3 to 28 in which at least one other component was added to Gujeolcho extract was superior to Comparative Example 2 using Gujeolcho extract alone.

Experimental Example 3 Clinical Trials of Hair Loss Patients

In order to determine the effect on the hair loss patient, a clinical trial was conducted on the hair growth and hair growth compositions of Examples 3 to 5 and Comparative Examples 1 to 3 in patients with alopecia.

The subjects were male and female alopecia areata among adult men and women over 20 years old. The test was carried out by spraying two to three times a day to five hair loss and hair loss parts of each of the hair growth and hair growth compositions of Examples 3 to 5 and Comparative Examples 1 to 3 for a minimum of 2 months to a maximum of 4 months .

Judgment of the effect was evaluated in five stages according to the evaluation scale of Table 11 by photographic findings and degree of improvement of subjective symptoms. The results are shown in Table 12 below.

step Visual judgment Subjective symptoms One Got worse Got worse 2 No change No change 3 Slightly improved Slightly improved 4 Improvements were made. Improvements were made. 5 Significantly improved Significantly improved

division Visual judgment Subjective symptoms Comparative Example 1 2.0 2.1 Comparative Example 2 3.0 3.2 Comparative Example 3 2.1 2.2 Example 3 3.8 4.1 Example 4 4.1 4.2 Example 5 4.2 4.3

As shown in the results of Table 12, the compositions of Examples 3 to 5 each containing tocopherol acetate and salicylic acid together with Gujeolcho extract more excellent than the composition of Comparative Example 2 containing only Gujeolcho extract or Comparative Example 3 containing only tocopherol acetate and salicylic acid. And a hair growth effect. Moreover, there was no effect in the comparative example 1 which does not contain the component of this invention, or the comparative example 3 containing only tocopherol acetate and salicylic acid.

No adverse events were found in all subjects during the trial period, indicating that they are safe for humans.

As described above, the hair growth and hair growth composition of the present invention contained at least one component that exhibits synergistic effect when used with Gujeolcho extract and Gujeolcho extract, and the hair growth and hair growth effect was superior to the existing minoxidil.

In addition, as a result of clinical trials do not show any side effects, it can be seen that the human body is safe and no side effects.

Claims (6)

Gujeolcho extract; And Tocopherol Acetate, Salicylic Acid, Dipanthenol, Nicotinamide, Biotin, Pentadecaneglycerides, Hinocthiol, Zinc Pyrithione, Climbazole, Nasturtium Extract, White Porcelain Extract, Red Ginseng Extract, Clove Extract, Ginger Extract, Birch Extract, Green Tea Extract, Hair growth and hair growth, characterized in that it comprises a single or a mixture thereof selected from the group consisting of Euiin extract, red sesame extract, Schizandra extract, Doin extract, leaflet extract, peony extract, red peony extract, fennel extract, pine needle extract and pine needle extract Composition. The method of claim 1, The gujeolcho extract hair growth and hair growth composition, characterized in that it comprises 0.0001 to 50 parts by weight based on 100 parts by weight of the total composition. The method of claim 1, Tocopherol acetate, salicylic acid, dipanthenol, nicotinic acid amide, biotin, pentadecaneglycerides, hinokithiol, zinc pyrithione, climbazole, nasturtium extract, white porcelain extract, red ginseng extract, cloves extract, ginger extract, birch extract, green tea extract , Euiin extract, red sesame extract, Schizandra extract, Doin extract, leaflet extract, peony extract, red peony extract, fennel extract, pine needle extract and pine needle extract, alone or mixtures thereof, based on 100 parts by weight of the total composition Hair growth and hair growth composition, characterized in that it comprises 0.001 to 10 parts by weight. The method of claim 1, The gujeolcho is a hair growth and hair growth composition, characterized in that the Wonjeolcho or furniture. The method of claim 1, The Gujeolcho extract is a hair growth and hair growth composition, characterized in that the organic solvent extract, water extract or supercritical extract. The method of claim 5, The organic solvent is a lower alcohol such as methanol, ethanol, isopropyl alcohol, butanol; Polyhydric alcohols such as glycerol, ethylene glycol, propylene glycol and 1, 3-butylene glycol; And petroleum ether, methyl acetate, ethyl acetate, benzene, hexane, methylene chloride, diethyl ether, dichloromethane, chloroform, and the like, or a mixture thereof.