CN109125207A - A kind of plant compound of antibacterial anti-acne and its preparation method and application - Google Patents
A kind of plant compound of antibacterial anti-acne and its preparation method and application Download PDFInfo
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Abstract
The present invention provides plant compound of a kind of antibacterial anti-acne and its preparation method and application, the composition includes following component in parts by weight: 30-90 parts of the root bark of tree peony, 0.6-0.9 parts of Ginger P.E and 10-70 parts of kuh-seng；The present invention carries out synergistic by using the very excellent root bark of tree peony of In Vitro Bacteriostasis effect, Ginger P.E and kuh-seng, optimize three's proportion, promote to seep ingredient-natural borneol using the higher plant of safety, effectively make effect molecule infiltration cuticula structure, give full play to the unique advantage of various plant components, the comprehensive growth and breeding for inhibiting bacterium, reduce acne related inflammation symptom, play the effect of releiving anti-acne, present invention process is simple, industrialization large-scale production can be achieved, good economic benefit can be brought for enterprise, have wide prospect.
Description
Technical field
The present invention relates to cosmetic fields, relate generally to a kind of plant compound and preparation method thereof of antibacterial anti-acne
And application.
Background technique
" acne " is being commonly called as acne, also referred to as whelk, acne, dark sore etc..Chinese medicine ancient times are called face sore, acne.
Acne is dermatology common disease, is a kind of disease for betiding pilosebaceous follicle.The cause of disease of acne is more complex, generally believes main
Be that following five kinds of reasons cause: male sex hormone is anti-to the exception adjusting of sebum secretion, keratinization exception, microorganism infection, inflammation
It answers, be immunoreacted.Microorganism infection among these, inflammatory reaction are again closely related with propionibacterium acnes.Meanwhile green pus bar
(verdigris vacation monospore) bacterium and the rehabilitation progress of acne middle and later periods are in close relations, it be also it is a kind of be easy to generate drug resistance it is thin
Bacterium.Therefore the botanical medicine prescription functional component of stable, wide spectrum anti-acne correlation bacterium, it appears particularly important.
Common anti-acne means are usually drug therapy, but cosmetics are disabled during drug therapy, are caused certain
Life puzzlement, therefore, the cosmetics with acne-removal function become another selection.Anti-acne class cosmetics currently on the market are more
Containing heavy metal or antibiotics raw material, big injury can be caused to consumer skin, therefore, using green natural plant at
The cosmetics of the effect of being allocated as the anti-acne factor become present market trend.
CN106552099A discloses a kind of Traditional chinese medicine medicament formula of Chinese medicine anti-acne, its main feature is that component are as follows: radix scrophulariae, life
Ground, radix paeoniae rubra, polygonum cuspidate, viola mandshurica, the root bark of tree peony, kuh-seng, the root bark of Chinese wolf-berry, raw hawthorn, cicada slough, Hedyotidis Diffusae, smilax；Every group of weight ratio
Are as follows: each 12 grams of radix scrophulariae, Radix Rehmanniae, radix paeoniae rubra, each 15 grams of polygonum cuspidate, viola mandshurica, the root bark of tree peony, kuh-seng, the root bark of Chinese wolf-berry, raw hawthorn, cicada slough each 10
Gram；Production instructions of taking: it is decocted in water for oral dose, day 2 times, it solves the problems, such as that existing drug therapy side effect is big, and being adapted to anti-acne makes
With.CN102048850B discloses a kind of traditional Chinese medicine for external application and preparation method thereof for treating infantile eczema, and treatment children are wet
The traditional Chinese medicine for external application of rash includes that component and its parts by weight are as follows: 80-150 parts of the coptis, 60-130 parts of kuh-seng, root bark of tree peony 40-120
Part, 20-100 parts of paniculate swallowwort and appropriate borneol.CN103041113B disclose a kind of plant compound gel for treating acne and
Preparation method, including natural plant component, the natural plant component and parts by weight are as follows: 20-30 parts of kuh-seng, root bark of tree peony 15-
25 parts, 10-20 parts of aloe, 10-20 parts of radix scutellariae, 15-25 parts of Radix Glycyrrhizae.A kind of plant compound for treating acne that the invention provides is solidifying
Jelly has natural plant active component, gelling agent and any common treatment made of the formula and preparation method by offer
The drug of anti-acne can be all used cooperatively, and be suitable for any skin, and without allergic reaction, be had no toxic side effect, and keep drug rapid
Skin is penetrated into, achievees the purpose that treat acne, it is curative for effect, uneasy to recur, there is removing acne and eliminating mark effect, collect natural plant active
Essence, rapid antibacterial, the detoxification sore treatment of energy, can improve color of the leather, restore skin, protect skin.Plant functional component generally has multiple
Miscellaneous space structure is difficult to permeate human skin keratinocyte's layer structure, some functional components can slowly permeate, but be not achieved effective
Prolific harmful bacteria cannot be killed or be inhibited to drug concentration.So rush permeable components appropriate and suitable drug agent
It is very important for type.Existing anti-acne plant formula, general floristics is relatively more, at least all 4 kinds or more plants.Plant
Type it is more, ingredient is more complicated, and slow chemical reaction is easy to happen between ingredient, this is to condition of storage, product formula, goods
The frame phase made higher requirement.Partial efficacy macromolecular components can use chemical enhancers due to poor permeability, this is again
Increase the risk of allergy.
In conclusion researching and developing a kind of simply and effectively treatment acne, inhibit bacterial growth comprehensively, permeability is high, ingredient letter
Single plant compound, has broad application prospects and huge market value.
Summary of the invention
To solve the deficiencies in the prior art with the demand in market, the present invention provides a kind of plant compound groups of antibacterial anti-acne
Object and its preparation method and application is closed, by rationally screening active component and proportion optimizing, gives full play to the uniqueness of plant component
Advantage, each component is synergistic, comprehensively antibacterial, plays the effect of releiving anti-acne, has broad application prospects and huge city
Field value.
To achieve the above object, the present invention adopts the following technical scheme:
In a first aspect, the present invention provides a kind of plant compound of antibacterial anti-acne, the composition is in parts by weight
Including following component: 30-90 parts of the root bark of tree peony, the Ginger P.E of 0.6-0.9 and 10-70 parts of kuh-seng.
In the present invention, inventor furthers investigate the deficiency of the antibacterial cosmetic field of anti-acne, and to solve, plant component is complicated, closes
At the big problem of medicine irritation, a kind of plant compound of simply and effectively treatment acne is provided, is imitated using In Vitro Bacteriostasis
The very excellent root bark of tree peony of fruit, Ginger P.E and kuh-seng carry out synergistic: kuh-seng has very excellent In Vitro Bacteriostasis effect,
The especially related bacterium of acne, such as propionibacterium acnes, staphylococcus epidermis, staphylococcus aureus, Candida albicans；It is red
Sword-shaped needle is more prominent to the inhibiting effect of Escherichia coli, Pseudomonas aeruginosa, and Ginger P.E is the new fresh root shape of Zingiber ginger ginger
Stem extraction, main component are zingiberene, zingiberol, heerabolene, α-curcumene, methyl heptenone etc., to staphylococcus aureus, white
Color staphylococcus, typhoid bacillus, sonne bacillus, Pseudomonas aeruginosa significantly inhibit effect；Optimize three's proportion, sufficiently
The unique advantage of various plant components is played, the comprehensive growth and breeding for inhibiting bacterium reduces acne related inflammation symptom, rise
To releive anti-acne the effect of, inhibition more comprehensively, more efficient or kill the relevant various bacteria of acne, reach the anti-acne of wide spectrum
Bacterium, the effect of effective anti-acne.In addition, kuh-seng heat-clearing and damp-drying drug, the light spot of root bark of tree peony clearing heat and cooling blood, can play the effect of releiving.
The parts by weight of the root bark of tree peony for example can be 30 parts, 40 parts, 50 parts, 60 parts, 70 parts, 80 parts or 90 parts, preferably
It is 40-80 parts.
The parts by weight of the kuh-seng for example can be 10 parts, 20 parts, 30 parts, 40 parts, 50 parts, 60 parts or 70 parts, preferably
It is 20-60 parts.
Preferably, the parts by weight of the Ginger P.E for example can be 0.6 part, 0.7 part, 0.8 part or 0.9 part.
Second aspect, the present invention provide the plant compound of one kind as described in relation to the first aspect and are used to prepare cosmetics
Using.
The third aspect, the present invention provide a kind of method for preparing composition as described in relation to the first aspect, include the following steps:
(1) root bark of tree peony and kuh-seng are weighed in proportion, is sliced, is sufficiently mixed, and obtain medicinal material mixture after dry；
(2) by 6-10 times of the medicinal material mixture quality of medicinal material of step (1), the ethanol solution of volumetric concentration 40-80%
Heating and refluxing extraction is concentrated into no alcohol taste, obtains concentrate；
(3) appropriate 1,3-BDO is added in the concentrate of step (2) to dissolve, centrifugation adds Ginger P.E, obtains
The composition.
Preferably, step (1) ratio is 40-80 parts of the root bark of tree peony and 20-60 parts of kuh-seng.
Preferably, step (1) drying is drying and/or dries.
Preferably, the dosage of step (2) described ethanol solution is 6-10 times of medicinal material mixture volume, such as can be 6
Again, 7 times, 8 times, 9 times or 10 times.
Preferably, the additive amount of step (3) described Ginger P.E is 0.6-0.9 parts.
Preferably, the appropriate 1,3-BDO is changed according to dissolubility, and range changes between 10-90%.
Preferably, the volumetric concentration of step (2) described ethanol solution is 40-80%, for example, can be 40%, 50%,
55%, 60%, 65%, 68%, 70%, 72%, 75%, 80%, preferably 65-75%.
Preferably, the quality of step (2) described ethanol solution is 6-10 times of quality of medicinal material, for example, can be 6 times, 7 times,
8 times, 9 times or 10 times.
Preferably, the ethanol solution is the aqueous solution of ethyl alcohol.
As optimal technical scheme, a method of plant compound as described in relation to the first aspect is prepared, is specifically included
Following steps:
(1) 40-80 parts of the root bark of tree peony and 20-60 parts of kuh-seng are weighed, is sliced, is sufficiently mixed, medicinal material mixing is obtained after dry
Object；
(2) by 6-10 times of volumetric concentration of the medicinal material mixture quality of medicinal material of step (1) be 65-75% ethyl alcohol it is molten
Liquid heating and refluxing extraction is concentrated into no alcohol taste, obtains concentrate；
(3) appropriate 1,3-BDO is added in the concentrate of step (2) to dissolve, centrifugation adds 0.6-0.9 parts of ginger
Extract obtains the composition.
Fourth aspect, the present invention provide a kind of cosmetics, and the toiletry bag is containing plant compound group described in first aspect
Close object.
Preferably, the cosmetics include any one in cream, lotion or essence, preferably cream.
Preferably, the cream includes following component according to parts by weight: 5 parts of plant compound, deionized water
68.3 parts, 3 parts of 1,3 butylene glycol, 5 parts of the different hard acid ester of isooctadecanol, 5 parts of glycerol, SEPIPLUS4001 parts, carbonic acid dibutyl ester 3
Part, 3 parts of PEG-20,2 parts of dimethyl silicone polymer, 2 parts of Gotu Kola P.E, 0.2 part of PCA-Zn, 0.8 part of acetyl chitosamine,
Camphortree leaf/0.5 part of branch/root extract, 0.5 part of 1,2- hexylene glycol, 0.5 part of parahydroxyacet-ophenone and 0.2 part of xanthan gum.
The present invention promotees to seep ingredient-natural borneol, i.e. camphortree leaf/branch/root extract, day using the higher plant of safety
It is so non-stimulated, while effectively making effect macromolecular permeation cuticula structure, utmostly play the effect of functional component.
5th aspect, the present invention provide a kind of preparation method of the cream of anti-acne of releiving, and described method includes following steps:
(1 ') in the first reaction kettle be added 68.3 parts of deionized water, 5 parts of glycerol, 0.2 part of xanthan gum be sufficiently stirred, suitably
Heating makes it dissolve into transparent paste, and it is spare to obtain A liquid；
3 parts of 1,3-BDO, 5 parts of plant compound, Gotu Kola P.E 2 is added in (2 ') in the second reaction kettle
It is part, 0.2 part of PCA-Zn, 0.8 part of acetyl chitosamine, camphortree leaf/branch/0.5-5 parts of root extract, 0.5 part of 1,2- hexylene glycol, right
It 0.5 part of hydroxy acetophenone, stirs evenly, it is spare to obtain C liquid；
(3 ') add 3 parts of PEG-20,5 parts of the different hard acid ester of isooctadecanol, 3 parts of carbonic acid dibutyl ester, poly- two in the second mixing kettle
It 2 parts of methylsiloxane, is heated to being completely dissolved, obtains B liquid, stop heating, A liquid pump is entered, after keeping two-phase mixtures uniform, is added
1 part of SEPIPLUS400, homogeneous makes it be uniformly dispersed.It is kept the temperature after being cooled to 60 DEG C, C liquid is added, is sufficiently stirred 0.5 hour, stops
Only heat preservation continues stirring 1 hour, stops stirring, discharges, packing, the compound cream for the acne that obtains medical treatment.
Compared with prior art, the present invention has the advantage that
Plant compound provided by the invention uses kuh-seng, Ginger P.E and the pellet of In Vitro Bacteriostasis excellent effect
Skin, and optimize its proportion, obtains the plant compound component of the excellent treatment acne of effect, can comprehensively, efficiently inhibit, kill it is more
Kind acne Related Bacteria, has the function that broad-spectrum antibacterial；Cosmetics provided by the invention use the root bark of tree peony, Ginger P.E, kuh-seng
It releives efficacy factor as anti-acne, natural borneol is to promote permeable components, and the ingredient is pure Chinese medicine ingredient, natural no stimulation,
While playing acne-removing secondary injury will not be caused to skin；Formula for dispelling pox is simplified, the root bark of tree peony, Ginger P.E are contained only
With a kind of rush permeable components of 3 kinds of functional components of kuh-seng and natural borneol, composition structure is simple, it is difficult to other chemical reactions occur,
Long-time stable is facilitated to store；The present invention uses natural borneol to substitute chemical enhancers as penetrating agent, and natural no stimulation avoids
The risk of allergy；Preparation method of the present invention is simple, wide market, is suitble to large-scale production.
Specific embodiment
Further to illustrate technological means and its effect adopted by the present invention, below in conjunction with preferred implementation of the invention
Example to further illustrate the technical scheme of the present invention, but the present invention is not limited in scope of embodiments.
Embodiment 1
(1) 60 parts of the root bark of tree peony and 40 parts of kuh-seng are weighed, is sliced, is sufficiently mixed, obtains medicinal material mixture after dry；
(2) medicinal material mixture of step (1) is heated with the ethanol solution that the volumetric concentration that volume multiple is 8 times is 70%
Refluxing extraction is concentrated into no alcohol taste, obtains concentrate；
(3) appropriate 1,3-BDO is added in the concentrate of step (2) to dissolve, centrifugation, adds 0.8 part of ginger and extracts
Object obtains the composition.
Embodiment 2
(1) 80 parts of the root bark of tree peony and 20 parts of kuh-seng are weighed, is sliced, is sufficiently mixed, obtains medicinal material mixture after dry；
(2) medicinal material mixture of step (1) is heated with the ethanol solution that the volumetric concentration that volume multiple is 6 times is 65%
Refluxing extraction is concentrated into no alcohol taste, obtains concentrate；
(3) appropriate 1,3-BDO is added in the concentrate of step (2) to dissolve, centrifugation, adds 0.6 part of ginger and extracts
Object obtains the composition.
Embodiment 3
(1) 40 parts of the root bark of tree peony and 60 parts of kuh-seng are weighed, is sliced, is sufficiently mixed, obtains medicinal material mixture after dry；
(2) medicinal material mixture of step (1) is added with the ethanol solution that the volumetric concentration that volume multiple is 10 times is 75%
Circumfluence distillation is concentrated into no alcohol taste, obtains concentrate；
(3) appropriate 1,3-BDO is added in the concentrate of step (2) to dissolve, centrifugation, adds 0.9 part of ginger and extracts
Object obtains the composition.
Embodiment 4
Compared with Example 1, in addition to medicinal material is changed to 10 parts of kuh-seng, the root bark of tree peony 30 especially, other conditions are same as Example 1.
Embodiment 5
Compared with Example 1, in addition to medicinal material is changed to 70 parts of kuh-seng, the root bark of tree peony 90 especially, other conditions are same as Example 1.
Comparative example 1
Compared with Example 1, in addition to medicinal material is changed to 1 part of kuh-seng, 0.8 part of Ginger P.E, the root bark of tree peony 99 especially, other conditions
It is same as Example 1.
Comparative example 2
Compared with Example 1, in addition to medicinal material is changed to 99 parts of kuh-seng, 0.8 part of Ginger P.E, the root bark of tree peony 1 especially, other conditions
It is same as Example 1.
Comparative example 3
Compared with Example 1, in addition to medicinal material is changed to 0.5 part of kuh-seng, 0.8 part of Ginger P.E, 0.5 part of the root bark of tree peony, Radix Glycyrrhizae 99
Especially, other conditions are same as Example 1.
Comparative example 4
A kind of drug for treating acne, including natural plant composition, the natural plant composition and parts by weight are as follows: kuh-seng
38.5 parts, 0.7 part of Ginger P.E, 38.5 parts of the root bark of tree peony, 23 parts of Radix Glycyrrhizae.
The natural plant composition the preparation method is as follows: by the root bark of tree peony, kuh-seng and Radix Glycyrrhizae according to above-mentioned formula rate, powder
It is broken to 60-80 mesh, becomes powdered, it is then stand-by in 50-70 DEG C of drying；By mixed medicinal material with the 70% of 5-8 times of volume
It after ethanol/water impregnates 24 hours, then extracts twice with 70% ethanol/water, extracting solution is concentrated under reduced pressure into no alcohol taste, is added and fits
1,3-BDO dissolution is measured, centrifugation adds Ginger P.E, obtains composition.
Comparative example 5
Compared with Example 1, other than not adding Ginger P.E, other conditions are same as Example 1.
Antibacterial experiment in vitro (MBC value)
MBC value is subject to and estimates sample without turbid phenomenon (or with control sample indifference that bacterium solution is not added), and bacterial strain is compiled
Number and bacterial concentration be shown in Table 1；
Table 1
Remarks: all first secondary culture of bacterial strain is to the 3rd to 8 generation, and just experiment uses.
Composition prepared by embodiment 1-3 and comparative example 1-4 carries out bacteriostatic experiment, the results are shown in Table 2 and table 3；
Table 2
Remarks: " √ " is the visible muddiness of naked eyes, as long bacterium."×" is that sample liquid is clarified or without obvious color difference, do not grown as
Bacterium.
Table 3
By table 2 and table 3 it is found that propionibacterium acnes, staphylococcus epidermis, staphylococcus aureus, Candida albicans etc.
It is very sensitive to comparative example 2 Deng four kinds of bacterium；Two kinds of bacterium such as escherichia coli, Pseudomonas aeruginosa are very sensitive to comparative example 1.Comparison
The collocation of the bacteriostatic experiment of example 2 and comparative example 1 can be complementary to one another, embodiment 1, comparative example 1, comparative example 5 and comparative example 2 it is external
Bacteriostatic experiment proves that the combination of kuh-seng, Ginger P.E, the root bark of tree peony does not conflict, and fungistatic effect can mutually promote, and implements
The fungistatic effect of example 2-5 is similar to Example 1.On the other hand, Candida albicans, Pseudomonas aeruginosa are insensitive to comparative example 3.Comparison
The antibacterial experiment in vitro of example 4 proves, if Radix Glycyrrhizae is added in prescription can reduce fungistatic effect, especially green pus bar to a certain degree
Bacterium.This may be that macromolecular ter penoids in Radix Glycyrrhizae occur a degree of react with effect ingredient in the root bark of tree peony, kuh-seng and have
Relationship, so Radix Glycyrrhizae is added in prescription element, non-optimal selection.In brief, embodiment 1-3 is according to technology provided by the invention
The composition fungistatic effect that scheme obtains is prominent, and the formula over range of comparative example 1,2 and 5, comparative example 3 and 4 is added to Radix Glycyrrhizae,
Fungistatic effect is decreased obviously, and therefore, kuh-seng, Ginger P.E and root bark of tree peony three mutually promote under special formulation, and collaboration increases
Effect has brilliant and comprehensive fungistatic effect.
The experiment of extracorporeal anti-inflammatory antiallergic
Since embodiment 1-5 fungistatic effect is similar, using the product of embodiment 1 as representative, in 2D cellular level with rouge
Polysaccharide (LPS) induction macrophage, active matter handle cell after, by mtt assay detect inflammatory factor (TNF α, IL-6,
NO it) the results are shown in Table shown in 4- table 7 with the variation of inflammatory mediator PGE2, anti-inflammatory Shu Min effect of comprehensive assessment composition；
4 TNF α testing result of table
As shown in Table 4, compared with solvent control group SC (LPS+) group, under the composition of 3% embodiment 1, make inflammation
Factor TNF α content significantly reduces, compared with solvent control SC (0.1%DMSO LPS+) group, in the composition of 3% embodiment 1
Under, significantly reduce inflammatory factor TNFalpha content.
5 PGE2 testing result of table
| Grouping | Mean value | SD | CV (%) | P value |
| SC-LPS- | 288.91 | 19.99 | 0.07 | / |
| 0.1%DMSO LPS- | 261.91 | 9.89 | 0.04 | / |
| Dexamethasone | 52371.65 | 369.35 | 0.01 | 0.02 |
| SC-LPS+ | 52602.01 | 1292.76 | 0.02 | 0.00 |
| 0.1%DMSO LPS+ | 56993.00 | 2087.43 | 0.04 | 0.00 |
| 3% embodiment 1 | 50913.50 | 4533.93 | 0.09 | 0.57 |
As shown in Table 5, compared with solvent control group SC (LPS+) group, under the composition of 3% embodiment 1, make inflammation
Medium PGE2 content significantly reduces, compared with solvent control SC (0.1%DMSO LPS+) group, in the combination of 3% embodiment 1
Under object, significantly reduce inflammatory mediator PGE2 content.
6 IL-6 testing result of table
As shown in Table 6, compared with solvent control group SC (LPS+) group, under the composition of 3% embodiment 1, make inflammation because
Sub- IL-6 content significantly reduces, compared with solvent control SC (0.1%DMSO LPS+) group, in the composition of 3% embodiment 1
Under, significantly reduce inflammatory factor IL-6 content.
7 NO testing result of table
| Grouping | Mean value | SD | CV (%) | P value |
| SC LPS- | 1.16 | 0.14 | 12.50 | / |
| 0.1%DMSO LPS- | 1.01 | 0.14 | 14.29 | / |
| Dexamethasone | 23.18 | 0.22 | 0.95 | 0.00 |
| SC LPS+ | 34.94 | 0.46 | 1.33 | 0.00 |
| 0.1%DMSO LPS+ | 29.83 | 0.22 | 0.74 | 0.00 |
| 3% component A1 | 33.15 | 0.22 | 0.67 | 0.00 |
As shown in Table 7, compared with solvent control group SC (LPS+) group, under the composition of 3% embodiment 1, make inflammation
Factor NO content significantly reduces.
By table 4- table 7 it is found that releiving extract with bright by the anti-acne that the root bark of tree peony, Ginger P.E and Radix Sophorae Flavescentis extractive liquid form
Aobvious anti-inflammatory the effect of releiving.
Percutaneous penetration:
Transdermal Absorption experiment is carried out using improved Franz diffusing cells method, is added into body outer osmotic disperser thermostat
Enter suitable quantity of water, under felicity condition, certain increasing soluble components can be added, set in thermostat that water temperature is 37 ± 0.1 DEG C, by fresh stripping
From depilation abdomen mouse skin be fixed between two Room diffusion cells with agrafe, stratum corneum side is to supply pool, and skin corium is towards receiving
Pond is added appropriate acceptable solution to the acceptance pool in vertical proliferation pond, is put into body outer osmotic disperser thermostat and preheats, setting connects
By pond mixing speed 400RPM, to supply pool be added quantitative kuh-seng, the root bark of tree peony, camphortree leaf/branch/root extract (camphortree leaf/branch/
Concentration of the root extract in prescription be 0%, 0.2%, 0.5%, 2.0%), sealed with preservative film it is suitable for reading, when Medicated Permeation 0h,
When 8h, sampling, centrifugation, sample preparation, then the peak area change rate of Paeonol, matrine is compared in HPLC analysis；
Peak area change rate=acceptance pool peak area (8h)/supply pool peak area (0h), the results are shown in Table 8；
Table 8
As shown in Table 8, camphortree leaf/branch/root extract to Paeonol, matrine have it is certain promote osmosis, concentration with
Certain positive correlation is presented in skin permeation rate.With the increase of concentration, skin permeation rate also increases, and promotees infiltration rate and reaches as high as 17.92%, by
It is natural borneol in camphortree leaf/branch/root extract main component, this rush for also demonstrating natural borneol to a certain extent seeps effect
Fruit.
Embodiment 6
The cream of preparation treatment acne, formula are shown in Table 9；
Table 9
The preparation method is as follows:
(1 ') be added in the first reaction kettle 68.3 parts of deionized water (71.3), 5 parts of glycerol, 0.2 part of xanthan gum sufficiently stir
It mixes, appropriate heating makes it dissolve into transparent paste, and it is spare to obtain A liquid；
3 parts of 1,3-BDO, 5 parts of plant compound, 2 parts of Gotu Kola P.E is added in (2 ') in the second reaction kettle
(0 part), 0.2 part of PCA-Zn (0 part), 0.8 part of acetyl chitosamine (0 part), camphortree leaf/0.5 part of branch/root extract (or being not added),
1,2- 0.5 part of hexylene glycol, 0.5 part of parahydroxyacet-ophenone, stir evenly, it is spare to obtain C liquid；
(3 ') add 3 parts of PEG-20,5 parts of the different hard acid ester of isooctadecanol, 3 parts of carbonic acid dibutyl ester, poly- two in the second mixing kettle
It 2 parts of methylsiloxane, is heated to being completely dissolved, obtains B liquid, stop heating, A liquid pump is entered, after keeping two-phase mixtures uniform, is added
1 part of SEPIPLUS400, homogeneous makes it be uniformly dispersed.It is kept the temperature after being cooled to 60 DEG C, C liquid is added, is sufficiently stirred 0.5 hour, stops
Only heat preservation continues stirring 1 hour, stops stirring, discharges, packing, the compound cream for the acne that obtains medical treatment.
Since in the cream of the treatment acne, other than plant compound, other compositions are essentially all that matrix is auxiliary
Material formula, it is little to the treatment acne potency due of product, the effect of Gotu Kola P.E is widely considered to be scar repairing ingredient,
Acetyl chitosamine and PCA-Zn are the ingredient contained into the cell and the derivative of ingredient, are had no in actual inhibition acne
Effect that bacterium is unbalance, as those skilled in the art, the proportion selection amount of auxiliary material can be grasped, and no longer be illustrated.
Cream product 1, product 2, product 3 to anti-acne of releiving are carried out to the security test of patch, experimental result is such as
The following table 10:
Table 10
Above data it can be shown that the cream product 1 of anti-acne of releiving, product 2, product 3 without skin adverse reaction, to skin
Skin irritation is low.
In conclusion the present invention provides plant compound of a kind of antibacterial anti-acne and its preparation method and application,
By rationally screening active component and proportion optimizing, the unique advantage of plant component is given full play to, each component is synergistic, comprehensively
It is antibacterial, the effect of releiving anti-acne is played, is had broad application prospects and huge market value.
The Applicant declares that the present invention is explained by the above embodiments method detailed of the invention, but the present invention not office
Be limited to above-mentioned method detailed, that is, do not mean that the invention must rely on the above detailed methods to implement.Technical field
Technical staff it will be clearly understood that any improvement in the present invention, equivalence replacement and auxiliary element to each raw material of product of the present invention
Addition, selection of concrete mode etc., all of which fall within the scope of protection and disclosure of the present invention.
Claims (10)
1. a kind of plant compound of antibacterial anti-acne, which is characterized in that the composition includes such as the following group in parts by weight
Point: 30-90 parts of the root bark of tree peony, 0.6-0.9 parts of Ginger P.E and 10-70 parts of kuh-seng.
2. compound according to claim 1, which is characterized in that the composition includes such as the following group in parts by weight
Point: 40-80 parts of the root bark of tree peony, 0.6-0.9 parts of Ginger P.E and 20-60 parts of kuh-seng.
3. the application that a kind of plant compound as claimed in claim 1 or 2 is used to prepare cosmetics.
4. a kind of method for preparing composition as claimed in claim 1 or 2, which comprises the steps of:
(1) root bark of tree peony and kuh-seng are weighed in proportion, is sliced, is sufficiently mixed, and obtain medicinal material mixture after dry；
(2) by the medicinal material mixture ethanol solution heating and refluxing extraction of step (1), it is concentrated into no alcohol taste, obtains concentrate；
(3) appropriate 1,3-BDO is added in the concentrate of step (2) to dissolve, centrifugation adds Ginger P.E, obtains described
Composition.
5. according to the method described in claim 4, it is characterized in that, step (1) drying is drying and/or dries.
6. method according to claim 4 or 5, which is characterized in that the dosage of step (2) described ethanol solution is mixed for medicinal material
6-10 times for closing object product；
Preferably, the additive amount of step (3) described Ginger P.E is 0.6-0.9 parts；
Preferably, the volumetric concentration of step (2) described ethanol solution is 40-80%, preferably 65-75%.
7. the method according to any one of claim 4-6, which is characterized in that specifically comprise the following steps:
(1) 40-80 parts of the root bark of tree peony and 20-60 parts of kuh-seng are weighed, is sliced, is sufficiently mixed, obtains medicinal material mixture after dry；
(2) by 6-10 times of the medicinal material mixture quality of medicinal material of step (1), volumetric concentration be 65-75% ethanol solution add
Circumfluence distillation is concentrated into no alcohol taste, obtains concentrate；
(3) appropriate 1,3-BDO is added in the concentrate of step (2) to dissolve, centrifugation, adds 0.6-0.9 parts of ginger and extracts
Object obtains the composition.
8. a kind of cosmetics, which is characterized in that the toiletry bag is containing plant compound described in as claimed in claim 1 or 22.
9. cosmetics according to claim 7, which is characterized in that the cosmetics include in cream, lotion or essence
Any one, preferably cream；
Preferably, the cream includes following component according to parts by weight: 5 parts of plant compound, 68.3 parts of deionized water,
5 parts of the different hard acid ester of 3 parts of 1,3 butylene glycol, isooctadecanol, 5 parts of glycerol, SEPIPLUS4001 parts, 3 parts of carbonic acid dibutyl ester, PEG-20
3 parts, 2 parts of dimethyl silicone polymer, 2 parts of Gotu Kola P.E, 0.2 part of PCA-Zn, 0.8 part of acetyl chitosamine, camphortree leaf/branch/
0.5 part of root extract, 0.5 part of 1,2- hexylene glycol, 0.5 part of parahydroxyacet-ophenone and 0.2 part of xanthan gum.
10. a kind of preparation method of the cream for anti-acne of releiving, which is characterized in that described method includes following steps:
(1 ') be added in the first reaction kettle 68.3 parts of deionized water, 5 parts of glycerol, 0.2 part of xanthan gum be sufficiently stirred, it is appropriate to heat
Transparent paste is made it dissolve into, it is spare to obtain A liquid；
(2 ') in the second reaction kettle be added 3 parts of 1,3-BDO, 5 parts of plant compound, 2 parts of Gotu Kola P.E,
0.2 part of PCA-Zn, 0.8 part of acetyl chitosamine, camphortree leaf/branch/0.5-5 parts of root extract, 0.5 part of 1,2- hexylene glycol, to hydroxyl
It 0.5 part of acetophenone, stirs evenly, it is spare to obtain C liquid；
(3 ') add 3 parts of PEG-20,5 parts of the different hard acid ester of isooctadecanol, 3 parts of carbonic acid dibutyl ester, poly dimethyl in the second mixing kettle
It 2 parts of siloxanes, is heated to being completely dissolved, obtains B liquid, stop heating, A liquid pump is entered, after keeping two-phase mixtures uniform, is added
1 part of SEPIPLUS400, homogeneous makes it be uniformly dispersed；It is kept the temperature after being cooled to 60 DEG C, C liquid is added, is sufficiently stirred 0.5 hour, stops
Only heat preservation continues stirring 1 hour, stops stirring, discharges, packing, the compound cream for the acne that obtains medical treatment.
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