CN109125207B

CN109125207B - Plant compound composition for inhibiting bacteria and removing acnes as well as preparation method and application thereof

Info

Publication number: CN109125207B
Application number: CN201811105909.8A
Authority: CN
Inventors: 金志强; 雷登凤; 高合意; 胡紫依; 吴新星; 曾飒
Original assignee: Guangzhou Ridgepole Biological Technology Co ltd
Current assignee: Guangzhou Ridgepole Biological Technology Co ltd
Priority date: 2018-09-21
Filing date: 2018-09-21
Publication date: 2021-11-16
Anticipated expiration: 2038-09-21
Also published as: CN109125207A

Abstract

The invention provides a plant compound composition for inhibiting bacteria and removing acnes as well as a preparation method and application thereof, wherein the composition comprises the following components in parts by weight: 30-90 parts of cortex moutan, 0.6-0.9 part of ginger extract and 10-70 parts of radix sophorae flavescentis; the cortex moutan, the ginger extract and the radix sophorae flavescentis which have excellent in-vitro antibacterial effect are adopted for synergistic interaction, the proportion of the cortex moutan, the ginger extract and the radix sophorae flavescentis is optimized, and the plant permeation promoting component with higher safety, namely the natural borneol, is adopted, so that the functional molecules can effectively permeate the stratum corneum structure, the unique advantages of various plant components can be fully exerted, the growth and the reproduction of bacteria can be comprehensively inhibited, the symptoms of related acne inflammation can be reduced, and the effect of relieving and removing acnes can be achieved.

Description

Plant compound composition for inhibiting bacteria and removing acnes as well as preparation method and application thereof

Technical Field

The invention relates to the field of cosmetics, and mainly relates to a plant compound composition for inhibiting bacteria and removing acnes, and a preparation method and application thereof.

Background

The acne is commonly known as acne and is also called as whelk, comedo, pimple and the like. The ancient Chinese medicine is called face sore and wine thorn. Acne is a common disease in dermatology and is a disease that occurs in the pilosebaceous glands. The causes of acne are complex and are generally thought to be mainly caused by the following five reasons: abnormal regulation of sebum secretion by androgens, abnormal keratinization, microbial infections, inflammatory responses, immune responses. The microbial infection and inflammatory reaction are closely related to the propionibacterium acnes. Meanwhile, pseudomonas aeruginosa is closely related to the healing progress of the middle and later stages of acne, and is a bacterium which is easy to generate drug resistance. Therefore, the stable and broad-spectrum plant medicine formula active ingredients for resisting the acne related bacteria are particularly important.

The common acne removing means is generally medication, but cosmetics are forbidden during medication, so that certain life trouble is caused, and therefore, the cosmetics with the acne removing function become another choice. The acne-removing cosmetics in the market contain heavy metals or antibiotics, which can cause great damage to the skin of consumers, so that the cosmetics using green natural plant components as the acne-removing efficacy factors have become the market trend.

CN106552099A discloses a traditional Chinese medicine formula for removing acne, which is characterized by comprising the following components: radix scrophulariae, radix rehmanniae, radix Paeoniae Rubra, rhizoma Polygoni Cuspidati, herba Violae, cortex moutan, radix Sophorae Flavescentis, cortex Lycii, fructus crataegi, periostracum Cicadae, herba Hedyotidis Diffusae, and rhizoma Smilacis Glabrae; each group of the compositions by weight ratio is as follows: figwort root, dried rehmannia root, red peony root each 12 g, giant knotweed rhizome, Chinese violet each 15 g, root bark of tree peony, flavescent sophora root, root bark of chinese wolf berry, haw, cicada slough each 10 g; the preparation and taking method comprises the following steps: the medicine is decocted in water for oral administration for 2 times a day, solves the problem of great side effect of the existing medicine treatment, and is suitable for acne treatment. CN102048850B discloses a traditional Chinese medicine external preparation for treating infantile eczema and a preparation method thereof, wherein the traditional Chinese medicine external preparation for treating infantile eczema comprises the following components in parts by weight: 80-150 parts of coptis chinensis, 60-130 parts of radix sophorae flavescentis, 40-120 parts of cortex moutan, 20-100 parts of paniculate swallowwort root and a proper amount of borneol. CN103041113B discloses a plant compound gel for treating acne and a preparation method thereof, the gel comprises natural plant components, the natural plant components and the parts by weight are as follows: 20-30 parts of sophora flavescens, 15-25 parts of cortex moutan, 10-20 parts of aloe, 10-20 parts of scutellaria baicalensis and 15-25 parts of liquorice. The plant compound gel for treating acne provided by the invention has natural plant active ingredients, can be used together with any common medicine for treating acne according to the formula and the preparation method, is suitable for any skin, has no anaphylactic reaction and toxic or side effect, can enable the medicine to quickly permeate into the skin to achieve the aim of treating acne, has definite curative effect and difficult recurrence, has the effects of removing acne and removing scars, integrates natural plant active essence, can quickly inhibit bacteria, detoxify and treat sore, can improve skin color, recover skin and protect skin. The plant functional components generally have complex spatial structures, are difficult to permeate into the stratum corneum structure of human skin, and some functional components can slowly permeate but cannot reach effective drug concentration, so that harmful bacteria which are propagated in large quantities cannot be killed or inhibited. Therefore, proper penetration-promoting ingredients and proper pharmaceutical dosage forms are very important. The existing acne-removing plant formula generally has more plant types, and at least more than 4 plants. The more the plant species, the more complex the ingredients, the slow chemical reaction between the ingredients is easy to occur, which puts higher demands on storage conditions, product formulation and shelf life. Part of the effective macromolecular components, due to the poor permeability, will be chemical penetration enhancers, which in turn increases the risk of allergy.

In conclusion, the plant compound composition which is simple and effective in treating acne, comprehensively inhibits bacterial growth, has high permeability and simple components is developed, and has wide application prospect and great market value.

Disclosure of Invention

In order to solve the defects of the prior art and the market demands, the invention provides the plant compound composition for inhibiting bacteria and removing acnes and the preparation method and application thereof.

In order to achieve the purpose, the invention adopts the following technical scheme:

in a first aspect, the invention provides a plant compound composition for inhibiting bacteria and removing acnes, which comprises the following components in parts by weight: 30-90 parts of cortex moutan, 0.6-0.9 part of ginger extract and 10-70 parts of radix sophorae flavescentis.

In the invention, the inventor deeply researches the defects in the field of acne-removing antibacterial cosmetics, provides a simple and effective plant compound composition for treating acne in order to solve the problems of complex plant components and large stimulation of synthetic drugs, and adopts cortex moutan, ginger extract and radix sophorae flavescentis which have very excellent in vitro antibacterial effect to perform synergistic interaction: the sophora flavescens has very excellent in-vitro antibacterial effect, and particularly has acne-related bacteria such as propionibacterium acnes, staphylococcus epidermidis, staphylococcus aureus and candida albicans; the cortex moutan has more remarkable inhibiting effect on escherichia coli and pseudomonas aeruginosa, the ginger extract is a fresh rhizome extract of ginger of Zingiber of Zingiberaceae, the main components are zingiberene, gingerol, bisabolene, alpha-curcumene, methyl heptenone and the like, and the extract has obvious inhibiting effect on staphylococcus aureus, staphylococcus albus, typhoid bacillus, Shigella sonnei and pseudomonas aeruginosa; the proportion of the three components is optimized, the unique advantages of various plant components are fully exerted, the growth and the reproduction of bacteria are comprehensively inhibited, the inflammation symptoms related to acne are reduced, the effect of relieving acne is achieved, various bacteria related to acne are more comprehensively and efficiently inhibited or killed, and the broad-spectrum acne-resisting bacteria and the effective acne-removing effect are achieved. In addition, the lightyellow sophora root can clear heat and dry dampness, and the cortex moutan can clear heat, cool blood and lighten spots, thereby having the effect of relieving.

The cortex moutan may be 30 parts, 40 parts, 50 parts, 60 parts, 70 parts, 80 parts or 90 parts by weight, preferably 40-80 parts.

The weight portion of the sophora flavescens can be 10 portions, 20 portions, 30 portions, 40 portions, 50 portions, 60 portions or 70 portions, and is preferably 20 to 60 portions.

Preferably, the weight part of the ginger extract may be, for example, 0.6 part, 0.7 part, 0.8 part or 0.9 part.

In a second aspect, the present invention provides a use of the plant compound composition according to the first aspect for preparing a cosmetic.

In a third aspect, the present invention provides a process for preparing a composition according to the first aspect, comprising the steps of:

(1) weighing cortex moutan and radix Sophorae Flavescentis according to a certain proportion, slicing, mixing thoroughly, and drying to obtain medicinal mixture;

(2) heating, refluxing and extracting the medicinal material mixture obtained in the step (1) by using an ethanol solution with the volume concentration of 40-80% 6-10 times of the mass of the medicinal materials, and concentrating until no alcohol smell exists to obtain a concentrate;

(3) and (3) adding a proper amount of 1, 3-butanediol into the concentrate obtained in the step (2) for dissolving, centrifuging, and adding a ginger extract to obtain the composition.

Preferably, the proportion in the step (1) is 40-80 parts of cortex moutan and 20-60 parts of radix sophorae flavescentis.

Preferably, the drying in step (1) is drying and/or airing.

Preferably, the ethanol solution in step (2) is used in an amount of 6-10 times of the volume of the medicinal material mixture, for example, 6 times, 7 times, 8 times, 9 times or 10 times.

Preferably, the ginger extract in the step (3) is added in an amount of 0.6-0.9 parts.

Preferably, the appropriate amount of 1, 3-butanediol is varied according to solubility, ranging between 10-90%.

Preferably, the ethanol solution of step (2) has a volume concentration of 40-80%, for example, 40%, 50%, 55%, 60%, 65%, 68%, 70%, 72%, 75%, 80%, preferably 65-75%.

Preferably, the mass of the ethanol solution in the step (2) is 6-10 times of the mass of the medicinal material, for example, 6 times, 7 times, 8 times, 9 times or 10 times.

Preferably, the ethanol solution is an aqueous solution of ethanol.

As a preferred technical scheme, a method for preparing the plant compound composition of the first aspect specifically comprises the following steps:

(1) weighing 40-80 parts of cortex moutan and 20-60 parts of radix sophorae flavescentis, slicing, fully mixing, and drying to obtain a medicinal material mixture;

(2) heating, refluxing and extracting the medicinal material mixture obtained in the step (1) by using an ethanol solution with the volume concentration of 65-75% 6-10 times of the mass of the medicinal materials, and concentrating until no alcohol smell exists to obtain a concentrate;

(3) and (3) adding a proper amount of 1, 3-butanediol into the concentrate obtained in the step (2) for dissolving, centrifuging, and adding 0.6-0.9 part of ginger extract to obtain the composition.

In a fourth aspect, the present invention provides a cosmetic comprising the plant compound composition of the first aspect.

Preferably, the cosmetic comprises any one of a cream, lotion or essence, preferably a cream.

Preferably, the cream comprises the following components in parts by weight: 5 parts of plant compound composition, 68.3 parts of deionized water, 3 parts of 1, 3-butanediol, 5 parts of isostearyl isostearate, 5 parts of glycerol, 5 parts of SEPIPLUS4001 parts, 3 parts of dioctyl carbonate, PEG-203 parts, 2 parts of polydimethylsiloxane, 2 parts of centella asiatica extract, 0.2 part of PCA-Zn, 0.8 part of acetyl chitosamine, 0.5 part of camphor tree leaf/branch/root extract, 0.5 part of 1, 2-hexanediol, 0.5 part of p-hydroxyacetophenone and 0.2 part of xanthan gum.

The invention adopts a plant penetration promoting component with higher safety, namely natural borneol, namely camphor tree leaves/branches/root extract, is natural and non-irritant, and simultaneously effectively enables effective macromolecules to penetrate a stratum corneum structure to exert the effect of the effective component to the maximum extent.

In a fifth aspect, the invention provides a preparation method of a cream for relieving acne, which comprises the following steps:

(1') adding 68.3 parts of deionized water, 5 parts of glycerol and 0.2 part of xanthan gum into a first reaction kettle, fully stirring, and properly heating to dissolve the materials into transparent paste to obtain solution A for later use;

(2') adding 3 parts of 1, 3-butanediol, 5 parts of plant compound composition, 2 parts of centella extract, 0.2 part of PCA-Zn, 0.8 part of acetyl chitosamine, 0.5-5 parts of camphor leaf/branch/root extract, 0.5 part of 1, 2-hexanediol and 0.5 part of p-hydroxyacetophenone into a second reaction kettle, and uniformly stirring to obtain a solution C for later use;

(3') adding PEG-203 parts, isostearyl isostearate 5 parts, dioctyl carbonate 3 parts and dimethyl silicone polymer 2 parts into a second mixing kettle, heating until the components are completely dissolved to obtain solution B, stopping heating, pumping solution A into the second mixing kettle, mixing the two phases uniformly, adding SEPIPLUS4001 parts, and homogenizing to uniformly disperse the two phases. Cooling to 60 deg.C, keeping the temperature, adding solution C, stirring for 0.5 hr, stopping stirring for 1 hr, stopping stirring, discharging, and packaging to obtain compound cream for treating acne.

Compared with the prior art, the invention has the following advantages:

the plant compound composition provided by the invention adopts the lightyellow sophora root and ginger extracts and the cortex moutan with excellent in-vitro antibacterial effect, and the proportion of the extracts and the cortex moutan is optimized to obtain the plant compound component with excellent effect for treating acne, so that various acne-related bacteria can be comprehensively and efficiently inhibited and killed, and the broad-spectrum antibacterial effect is achieved; the cosmetic provided by the invention adopts cortex moutan, ginger extract and radix sophorae flavescentis as acne-removing and soothing efficacy factors, and natural borneol is a penetration-promoting component, and the components are pure traditional Chinese medicine components, are natural and non-irritant, and cannot cause secondary damage to skin while exerting acne-removing efficacy; the acne removing formula is simplified, only 3 functional components of cortex moutan, ginger extract, radix sophorae flavescentis and 1 penetration promoting component of natural borneol are contained, the composition is simple in structure, other chemical reactions are difficult to occur, and the composition is convenient to store stably for a long time; the natural borneol is used as the penetration enhancer to replace a chemical penetration enhancer, is natural and non-irritant, and avoids the risk of allergy; the preparation method is simple, has wide market prospect and is suitable for large-scale production.

Detailed Description

To further illustrate the technical means and effects of the present invention, the following further describes the technical solution of the present invention with reference to the preferred embodiments of the present invention, but the present invention is not limited to the scope of the embodiments.

Example 1

(1) Weighing 60 parts of cortex moutan and 40 parts of radix sophorae flavescentis, slicing, fully mixing, and drying to obtain a medicinal material mixture;

(2) heating and refluxing the medicinal material mixture obtained in the step (1) by using an ethanol solution with the volume multiple of 8 and the volume concentration of 70%, and concentrating until no alcohol smell exists to obtain a concentrate;

(3) and (3) adding a proper amount of 1, 3-butanediol into the concentrate obtained in the step (2) for dissolving, centrifuging, and adding 0.8 part of ginger extract to obtain the composition.

Example 2

(1) Weighing 80 parts of cortex moutan and 20 parts of radix sophorae flavescentis, slicing, fully mixing, and drying to obtain a medicinal material mixture;

(2) heating and refluxing the medicinal material mixture obtained in the step (1) by using an ethanol solution with 6 times of volume and 65% of volume concentration, and concentrating until no alcohol smell exists to obtain a concentrate;

(3) and (3) adding a proper amount of 1, 3-butanediol into the concentrate obtained in the step (2) for dissolving, centrifuging, and adding 0.6 part of ginger extract to obtain the composition.

Example 3

(1) Weighing 40 parts of cortex moutan and 60 parts of radix sophorae flavescentis, slicing, fully mixing, and drying to obtain a medicinal material mixture;

(2) heating and refluxing the medicinal material mixture obtained in the step (1) by using an ethanol solution with the volume multiple of 10 and the volume concentration of 75%, and concentrating until no alcohol smell exists to obtain a concentrate;

(3) and (3) adding a proper amount of 1, 3-butanediol into the concentrate obtained in the step (2) for dissolving, centrifuging, and adding 0.9 part of ginger extract to obtain the composition.

Example 4

Compared with the example 1, the conditions are the same as the example 1 except that the medicinal materials are changed into 10 parts of radix sophorae flavescentis and 30 parts of cortex moutan.

Example 5

Compared with the example 1, the conditions are the same as the example 1 except that the medicinal materials are replaced by 70 parts of the lightyellow sophora root and 90 parts of the cortex moutan.

Comparative example 1

Compared with the example 1, the conditions are the same as the example 1 except that the medicinal materials are changed into 1 part of radix sophorae flavescentis, 0.8 part of ginger extract and 99 parts of cortex moutan.

Comparative example 2

Compared with the example 1, the conditions are the same as the example 1 except that the medicinal materials are changed into 99 parts of radix sophorae flavescentis, 0.8 part of ginger extract and 1 part of cortex moutan.

Comparative example 3

Compared with the example 1, the conditions are the same as the example 1 except that the medicinal materials are changed into 0.5 part of radix sophorae flavescentis, 0.8 part of ginger extract, 0.5 part of cortex moutan and 99 parts of liquorice.

Comparative example 4

The medicine for treating acne comprises natural plant components in parts by weight: 38.5 parts of sophora flavescens, 0.7 part of ginger extract, 38.5 parts of cortex moutan and 23 parts of liquorice.

The preparation method of the natural plant components comprises the following steps: pulverizing cortex moutan, radix Sophorae Flavescentis and Glycyrrhrizae radix into 60-80 mesh powder according to the above formula ratio, and oven drying at 50-70 deg.C; soaking the mixed medicinal materials in 5-8 times of 70% ethanol/water for 24 hr, extracting with 70% ethanol/water twice, concentrating the extractive solution under reduced pressure until there is no ethanol smell, adding appropriate amount of 1, 3-butanediol for dissolving, centrifuging, and adding rhizoma Zingiberis recens extract to obtain the composition.

Comparative example 5

The conditions were the same as in example 1 except that ginger extract was not added, compared to example 1.

In vitro bacteriostasis experiment (MBC value)

The MBC value is based on that the visual sample has no turbidity (or has no difference with a reference sample without adding bacterial liquid), and the serial number of the strain and the concentration of the bacterial liquid are shown in Table 1;

TABLE 1

Remarking: the strains were subcultured to 3 rd to 8 th generations before experimental use.

The compositions prepared in examples 1 to 3 and comparative examples 1 to 4 were subjected to bacteriostatic experiments, and the results are shown in tables 2 and 3;

TABLE 2

Remarking: "√" indicates a turbidity visible to the naked eye, i.e., a long bacterial growth. "X" means that the sample liquid is clear or has no obvious color difference, namely no bacteria grow.

TABLE 3

As can be seen from tables 2 and 3, Propionibacterium acnes, Staphylococcus epidermidis, Staphylococcus aureus, Candida albicans and the like were very sensitive to comparative example 2; two species of bacteria, e.g., Escherichia coli and Pseudomonas aeruginosa, were very sensitive to comparative example 1. The antibacterial experiment matching of the comparative example 2 and the comparative example 1 can complement each other, and the in vitro antibacterial experiments of the example 1, the comparative example 5 and the comparative example 2 prove that the combination of the radix sophorae flavescentis, the ginger extract and the cortex moutan is not conflicted, the antibacterial effects can be mutually promoted, and the antibacterial effects of the examples 2 to 5 are similar to the antibacterial effect of the example 1. On the other hand, Candida albicans and Pseudomonas aeruginosa were not sensitive to control 3. The in vitro bacteriostasis experiment of the comparative example 4 proves that if the liquorice is added into the formula, the bacteriostasis effect, especially the pseudomonas aeruginosa, can be reduced to a certain degree. The reaction relationship between macromolecular terpenoid components in the liquorice and the effective components in the cortex moutan and the radix sophorae flavescentis is possibly generated to a certain degree, so that the liquorice is added into the components of the formula and is not selected optimally. In short, the compositions obtained in the embodiments 1 to 3 according to the technical scheme provided by the invention have outstanding antibacterial effect, the formulas of the comparative examples 1,2 and 5 exceed the range, and the antibacterial effect of the comparative examples 3 and 4 is obviously reduced by adding the liquorice, so that the sophora flavescens, the ginger extract and the cortex moutan are mutually promoted and synergized under a specific formula, and have excellent and comprehensive antibacterial effect.

In vitro anti-inflammatory and anti-allergic experiment

Since the bacteriostatic effects of examples 1-5 were similar, using the product of example 1 as a representative, the changes of inflammatory factors (TNF α, IL-6, NO) and inflammatory mediators PGE2 were detected by MTT method after treating cells with the active substance by Lipopolysaccharide (LPS) induced macrophages at 2D cell level, and the anti-inflammatory and anti-allergy effects of the composition were comprehensively evaluated, and the results are shown in tables 4-7;

TABLE 4 TNF α assay results

As can be seen from table 4, the content of inflammatory factor TNF α was significantly reduced in the case of the composition of example 1 at 3% compared to the solvent control SC (LPS +) group, and in the case of the composition of example 1 at 3% compared to the solvent control SC (0.1% DMSO LPS +) group.

TABLE 5 PGE2 test results

Grouping	Mean value	SD	CV(％)	P value
					SC-LPS-	288.91	19.99	0.07	/
0.1％DMSO LPS-	261.91	9.89	0.04	/
					Dexamethasone	52371.65	369.35	0.01	0.02
SC-LPS+	52602.01	1292.76	0.02	0.00
					0.1％DMSO LPS+	56993.00	2087.43	0.04	0.00
3% example 1	50913.50	4533.93	0.09	0.57

As can be seen from table 5, the content of the inflammatory mediator PGE2 was significantly reduced in the case of the 3% composition of example 1 compared to the solvent control SC (LPS +) group, and the content of the inflammatory mediator PGE2 was significantly reduced in the case of the 3% composition of example 1 compared to the solvent control SC (0.1% DMSO LPS +) group.

TABLE 6 IL-6 assay results

As is clear from Table 6, the content of the inflammatory factor IL-6 was significantly reduced in the case of the composition of example 1 at 3% as compared with the solvent control SC (LPS +) group, and the content of the inflammatory factor IL-6 was significantly reduced in the case of the composition of example 1 at 3% as compared with the solvent control SC (0.1% DMSO LPS +) group.

TABLE 7 NO test results

Grouping	Mean value	SD	CV(％)	P value
					SC LPS-	1.16	0.14	12.50	/
0.1％DMSO LPS-	1.01	0.14	14.29	/
					Dexamethasone	23.18	0.22	0.95	0.00
SC LPS+	34.94	0.46	1.33	0.00
					0.1％DMSO LPS+	29.83	0.22	0.74	0.00
3% of component A1	33.15	0.22	0.67	0.00

As can be seen from table 7, the content of inflammatory factor NO was significantly reduced in the composition of example 1 at 3% as compared with the SC (LPS +) group of the solvent control group.

As can be seen from tables 4-7, the anti-acne soothing extract consisting of the cortex moutan, the ginger extract and the sophora flavescens extract has obvious anti-inflammatory soothing effects.

In vitro transdermal experiments:

adopting an improved Franz diffusion cell to carry out an in-vitro transdermal absorption experiment, adding a proper amount of water into a constant temperature tank of an in-vitro permeation diffusion device, adding a certain solubilizing component under proper conditions, setting the water temperature in the constant temperature tank to be 37 +/-0.1 ℃, fixing a freshly peeled unhaired abdominal rat skin between two diffusion cells by using an iron clamp, enabling a horny layer to face a supply cell and a corium layer to face a receiving cell, adding a proper amount of receiving liquid into a receiving cell of a vertical diffusion cell, preheating the heated unhaired rat skin in the constant temperature tank of the in-vitro permeation diffusion device, setting the stirring speed of the receiving cell to be 400RPM, adding quantitative radix sophorae flavescentis, cortex moutan and camphor tree leaves/branches/root extracts (the concentration of the camphor tree leaves/branches/root extracts in a formula is 0%, 0.2%, 0.5% and 2.0%), sealing an upper opening by using a preservative film, sampling, centrifuging, preparing samples, and analyzing and comparing paeonol, and the like by HPLC analysis, and the like, Peak area change rate of matrine;

the peak area change rate was set to the peak area of the receiving pool (8 h)/the peak area of the feeding pool (0h), and the results are shown in table 8;

TABLE 8

As can be seen from table 8, the camphor tree leaf/branch/root extract has a certain effect of promoting penetration of paeonol and matrine, and the concentration and the transdermal rate show a certain positive correlation. The skin penetration rate is increased along with the increase of the concentration, the permeation promoting rate can reach 17.92 percent at most, and the main component of the camphor tree leaf/branch/root extract is natural borneol, so the permeation promoting effect of the natural borneol is verified to a certain extent.

Example 6

The cream for treating acne is prepared, and the formula is shown in table 9;

TABLE 9

The preparation method comprises the following steps:

(1') adding 68.3 parts of deionized water (71.3), 5 parts of glycerol and 0.2 part of xanthan gum into a first reaction kettle, fully stirring, and properly heating to dissolve the materials into transparent paste to obtain solution A for later use;

(2') adding 3 parts of 1, 3-butanediol, 5 parts of plant compound composition, 2 parts (0 part) of centella extract, 0.2 part (0 part) of PCA-Zn, 0.8 part (0 part) of acetylcysteine, 0.5 part (or not) of camphor tree leaf/branch/root extract, 0.5 part of 1, 2-hexanediol and 0.5 part of p-hydroxyacetophenone into a second reaction kettle, and uniformly stirring to obtain a solution C for later use;

Because the cream for treating acne basically adopts the formula of the matrix auxiliary materials except the plant compound composition, the effect of the cream for treating acne is not greatly influenced, the centella asiatica extract is generally regarded as an effective component for repairing scars, the acetylcysteine and PCA-Zn are components and derivatives of the components contained in cells, and the actual effect of inhibiting bacterial imbalance in acne is not realized.

The cream products 1,2 and 3 for relieving and removing acnes are subjected to spot-sticking safety test, and the experimental results are shown in the following table 10:

watch 10

The data show that the cream products 1,2 and 3 for relieving acne have no adverse reaction to skin and low irritation to skin.

In conclusion, the plant compound composition for inhibiting bacteria and removing acnes and the preparation method and application thereof provided by the invention have the advantages that the unique advantages of plant components are fully exerted by reasonably screening the active components and optimizing the proportion, the components are synergistic in synergy and comprehensively inhibited bacteria, the effect of relieving acnes is achieved, and the plant compound composition has wide application prospect and great market value.

The applicant states that the present invention is illustrated in detail by the above examples, but the present invention is not limited to the above detailed methods, i.e. it is not meant that the present invention must rely on the above detailed methods for its implementation. It should be understood by those skilled in the art that any modification of the present invention, equivalent substitutions of the raw materials of the product of the present invention, addition of auxiliary components, selection of specific modes, etc., are within the scope and disclosure of the present invention.

Claims

1. The plant compound composition for inhibiting bacteria and removing acnes applied to cosmetics is characterized by comprising the following components in parts by weight: 30-90 parts of cortex moutan, 0.6-0.9 part of ginger extract and 10-70 parts of radix sophorae flavescentis;

the plant compound composition for inhibiting bacteria and removing acnes applied to cosmetics is prepared by the following method:

(2) heating and refluxing the medicinal material mixture obtained in the step (1) by using an ethanol solution, wherein the dosage of the ethanol solution is 6-10 times of the volume of the medicinal material mixture, the volume concentration of the ethanol solution is 65-75%, and concentrating until no alcohol smell exists to obtain a concentrate;

2. The compound composition of claim 1, wherein the composition comprises the following components in parts by weight: 40-80 parts of cortex moutan, 0.6-0.9 part of ginger extract and 20-60 parts of radix sophorae flavescentis.

3. Use of a plant compound composition according to claim 1 or 2 for the preparation of a cosmetic product.

4. A process for preparing the composition of claim 1 or 2, comprising the steps of:

5. The method of claim 4, wherein the drying of step (1) is oven drying and/or air drying.

6. A cosmetic comprising the plant compound composition according to claim 1 or 2.

7. The cosmetic according to claim 6, wherein the cosmetic comprises any one of a cream, a lotion or a essence.

8. The cosmetic according to claim 7, wherein the cosmetic is a cream.

9. The cosmetic according to claim 7, wherein the cream comprises the following components in parts by weight: 5 parts of plant compound composition, 68.3 parts of deionized water, 3 parts of 1, 3-butanediol, 5 parts of isostearyl isostearate, 5 parts of glycerol, 5 parts of SEPIPLUS4001 parts, 3 parts of dioctyl carbonate, PEG-203 parts, 2 parts of polydimethylsiloxane, 2 parts of centella asiatica extract, 0.2 part of PCA-Zn, 0.8 part of acetyl chitosamine, 0.5 part of camphor tree leaf/branch/root extract, 0.5 part of 1, 2-hexanediol, 0.5 part of p-hydroxyacetophenone and 0.2 part of xanthan gum.

10. A method of preparing a cream according to claim 9, wherein the method comprises the steps of:

(1) adding 68.3 parts of deionized water, 5 parts of glycerol and 0.2 part of xanthan gum into a first reaction kettle, fully stirring, and properly heating to dissolve the materials into transparent paste to obtain solution A for later use;

(2) adding 3 parts of 1, 3-butanediol, 5 parts of plant compound composition, 2 parts of centella extract, 0.2 part of PCA-Zn, 0.8 part of acetyl chitosamine, 0.5-5 parts of camphor tree leaf/branch/root extract, 0.5 part of 1, 2-hexanediol and 0.5 part of p-hydroxyacetophenone into a second reaction kettle, and uniformly stirring to obtain a solution C for later use;

(3) adding PEG-203 parts, isostearyl isostearate 5 parts, dioctyl carbonate 3 parts and polydimethylsiloxane 2 parts into a second mixing kettle, heating until the components are completely dissolved to obtain solution B, stopping heating, pumping the solution A into the second mixing kettle, uniformly mixing the two phases, adding SEPIPLUS4001 parts, and homogenizing to uniformly disperse the two phases; cooling to 60 deg.C, keeping the temperature, adding solution C, stirring for 0.5 hr, stopping stirring for 1 hr, stopping stirring, discharging, and packaging to obtain compound cream for treating acne.