CN105662962B - A kind of Whelk-eliminating paste based on high-purity herb extract and preparation method thereof - Google Patents
A kind of Whelk-eliminating paste based on high-purity herb extract and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/064—Saccharomycetales, e.g. baker's yeast
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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Abstract
The present invention provides a kind of Whelk-eliminating paste based on high-purity herb extract and preparation method thereof, and specific preparation method is：(1) above-mentioned natural herbs are cleaned after drying, cutting is pulverized, and is mixed according to the above ratio, adds in ethanol water, and filtrate rotary evaporation through circumfluence distillation 2 times, is concentrated into no alcohol taste, obtains the extracting solution of natural herbs by ultrasonic disperse；(2) by the extracting solution centrifuging and taking supernatant of natural herbs, it is subsequently placed in dry macroreticular resin, it stands and filters, the macroreticular resin after absorption is transferred in 80 90% ethanol water again, it stands and filters, take out macroreticular resin, by filtrate rotary evaporation to no alcohol taste, the natural herbs extracting solution purified；(3) above-mentioned auxiliary agent is mixed, 80 90 DEG C of heating stirrings are complete to dissolving, and are cooled to 45 50 DEG C, add in the natural herbs extracting solution of purifying, stir evenly, and heat preservation rotary evaporation obtains the Whelk-eliminating paste based on high-purity herb extract in paste.
Description
Technical field：
The invention belongs to daily cosmetics technical fields, and in particular to a kind of Whelk-eliminating paste based on high-purity herb extract
And preparation method thereof.
Background technology：
Acne, also referred to as whelk, dark sore and acne are a kind of chronic inflammatory diseases for betiding pilosebaceous follicle, mainly
Betide face and the back in puberty and manhood youth of both sexes, leprosy trace can be left by dealing with improperly, seriously affect people villus,
Employment, social and marriage and childbirth etc..Acne and androgen levels raising, sebum secretion increase, hair follicle conduit hyperkeratinization, Propionibacterium
The factors such as infection are related, and traditional treatment skill needs to be controlled using antibiotic, male sex hormone antagonist, tretinoin medicines
It treats, but toxic side effect is apparent.With the continuous improvement of people's living standards, people increasingly focus on the environmental protection of daily chemical product
Property, safety and natural sex, therefore the acne species cosmetics based on traditional Chinese medicine ingredients have become hot spot.
Cosmetics science and technology content is relatively low at present, and the raw material used is mostly chemical substance, can cause
Serious toxic side effect and allergic reaction.Treatment for acne has been recorded a variety of with clearing heat and detoxicating cool in successive dynasties medical book
The Chinese medicine of blood wind-dispelling, such Chinese medicine can directly act on the surface with acne pathogens, prevent the process of inflammation, reach anti-acne or
Improve the purpose of acne symptom, and quick, Small side effects.
A kind of beauty acne-removing composition and its system disclosed in Chinese patent CN 101502588B (publication date 2009.8.12)
Preparation Method is made of the following raw material：Radix rehmanniae recen, loguat leaf, the root bark of tree peony, cape jasmine, the radix paeoniae rubrathe, radix scutellariae, the root bark of white mulberry, Radix Glycyrrhizae, the beauty are dispelled
Acne composition can be made into internal dosage form, to the high efficiency of the treatment of whelk up to 98%, skin exquisiteness can also be made delicate, rich
It is flexible.A kind of cosmetics with acne-removal function disclosed in Chinese patent CN 103432024B (publication date 2013.12.11)
Composition, the active constituent of the cosmetic composition include radix scutellariae, wild chrysanthemum, honeysuckle, cape jasmine, moutan bark and the radix paeoniae rubrathe, prepare
It obtains easy natural herbs and is the cosmetics of primary raw material, and tested through function assessment, there is antibacterial and anti-inflammatory.China
A kind of mild effective removing acnes and controlling oil composition and its preparation disclosed in patent CN 104188849A (publication date 2014.12.10)
Method, the removing acnes and controlling oil composition include ABC components, and component A is deionized water, Sodium Hyaluronate, glycerine, propylene glycol, hydroxyl second
Base cellulose and allantoin, B component are D-pantothenyl aleohol, white willow bark extract, zinc paraphenol sulfonate, Herba portulacae extract, C groups
It is divided into preservative, essence and Cremophor RH40, acne-removing composition prepared by the present invention passes through the reasonable of tri- kinds of components of ABC
Compounding has moisturizing, adjusts the multi-efficiencies such as grease balance, anti-inflammatory and anti-acne, and colleague can improve the cure rate of acne, not have
Side effect.
By the above-mentioned prior art it is found that the Chinese traditional medicine composition with clearing heat and detoxicating cooling blood, expelling wind is as functional raw material, with it
His raw material compounds to obtain the composition with acne-removal function, but the purity requirement of traditional Chinese medicine ingredients is not more in being combined for anti-acne
See, therefore limited the effect of the anti-acne combination of preparation, effect floating is also larger, and performance is unstable.
Invention content：
The technical problem to be solved in the present invention is to provide a kind of Whelk-eliminating paste based on high-purity herb extract and its preparations
Method, the present invention select centella, giant knotweed, radix scutellariae, tealeaves, glycyrrhiza glabra, Flos Chrysanthemi, rosemary, white according to theory of traditional Chinese medical science
Willow, spiked gingerlily fruit, Radix Salviae Miltiorrhizae, gentian, loguat leaf, licorice, honeysuckle flowers, marigold and daisy are as major function raw material, through returning
The extracting solution of the natural herbs of stream extraction and the isolated high extraction high-purity of macroreticular resin, by adding other auxiliary agents
Form the Whelk-eliminating paste based on high-purity herb extract.Contain in Whelk-eliminating paste based on high-purity herb extract prepared by the present invention
There are many effective active composition, have effects that heat-clearing and damp-drying drug, purging intense heat and detonicating, anti-inflammatory are dispelled swollen, promoting blood circulation and removing blood stasis, Whitening, spot, work(
Energy property is good, and makes the stability of Whelk-eliminating paste, safety, guaranteeing the quality property good by adding auxiliary agent.
In order to solve the above technical problems, the technical scheme is that：
A kind of Whelk-eliminating paste based on high-purity herb extract, which is characterized in that under the active constituent of the Whelk-eliminating paste has
The natural herb extract stated by weight ratio is formed：Centella 5-20, giant knotweed 8-25, radix scutellariae 3-16, tealeaves 2-8, light fruit
Radix Glycyrrhizae 4-12, Flos Chrysanthemi 5-10, rosemary 3-9, white willow 5-15, spiked gingerlily fruit 6-14, Radix Salviae Miltiorrhizae 10-20, gentian 5-10, loguat leaf
8-18, licorice 5-9, honeysuckle flowers 4-19, marigold 3-11, daisy 5-13.
Preferably, the recovery rate of the natural herb extract is higher than 80%, and the purity of the natural herb extract is high
In 87%.
Preferably, beer yeast extract, grape fruit cell extract and auxiliary agent are also contained in the Whelk-eliminating paste.
Preferably, auxiliary agent includes in the Whelk-eliminating paste：Deionized water, butanediol, propylene glycol, glycine betaine, urea, polyglutamic
Sour sodium, isononyl isononanoate, dimethyl silicone polymer, ring five dimethyl silicone polymer, cetostearyl alcohol, cetanol, glycerine are hard
Resin acid ester, PEG-75 distearates, ceteth -20, stereth -20, carbomer, allantoin, Laurocapram,
Tridecanol salicylate, menthol, quaternary ammonium salt -73, beta glucan, triethanolamine, polyacrylate -13, the poly- isobutyl of hydrogenation
Alkene, polysorbate -20, camphor, 1,2- hexylene glycols, decoyl hydroximic acid, 1,3- propylene glycol, hexylene glycol and essence.
The present invention also provides a kind of preparation methods of the Whelk-eliminating paste based on high-purity herb extract, it is characterised in that：Packet
Include following steps：
(1) above-mentioned natural herbs are cleaned after drying, cutting is pulverized, and is mixed according to the above ratio, adds in ethyl alcohol
Filtrate rotary evaporation through circumfluence distillation 2 times, is concentrated into no alcohol taste, obtains natural herbs by aqueous solution, ultrasonic disperse
Extracting solution；
(2) the extracting solution centrifuging and taking supernatant for the natural herbs for preparing step (1), is subsequently placed in dry macropore
It in resin, stands and filters, then the macroreticular resin after absorption is transferred in the ethanol water of 80-90%, stand and filter, take out
Macroreticular resin, by filtrate rotary evaporation to no alcohol taste, the natural herbs extracting solution purified；
(3) above-mentioned auxiliary agent is mixed, 80-90 DEG C of heating stirring is complete to dissolving, and is cooled to 45-50 DEG C, adds in step (2)
The natural herbs extracting solution of the purifying of preparation, stirs evenly, and is eventually adding beer yeast extract, grape fruit cell extraction
Object, heat preservation rotary evaporation obtain the Whelk-eliminating paste based on high-purity herb extract in paste.
As a preferred embodiment of the above technical solution, in the step (1), the first time of circumfluence distillation：Ethanol water
A concentration of 80-95%, materials ratio are 1:8-10, temperature be 80-100 DEG C, extraction time 2-4h, the second of circumfluence distillation
It is secondary：A concentration of 60-80% of ethanol water, materials ratio are 1:5-6, temperature are 75-80 DEG C, extraction time 1-2h.
As a preferred embodiment of the above technical solution, in the step (1), active ingredient in the extracting solution of natural herbs
Recovery rate is 80-90%.
As a preferred embodiment of the above technical solution, in the step (2), dry macroreticular resin for compound-JD resins and
HPD-750 resins.
As a preferred embodiment of the above technical solution, in the step (2), the time of standing is 12-24h, filters 4-6h.
As a preferred embodiment of the above technical solution, in the step (2), in the natural herbs extracting solution of purifying into
Point, by weight, include 25-50 parts of rheum emodin, 15-35 parts of Chrysophanol, 20-30 parts of scutelloside, 15-25 parts of salicin, pellet
Join 20-40 parts of ketone, 10-15 parts of gentiamarin, 15-20 parts of ursolic acid, 5-10 parts of glycyrrhizic acid, 5-10 parts of chlorogenic acid, chrysanthemum flavones
15-25 parts, 15-20 parts of resveratrol, 5-10 parts of Rosmarinic acid.
Compared with prior art, the invention has the advantages that：
(1) the present invention is based on theories of traditional Chinese medical science, for the pathogenesis of acne, select centella, giant knotweed, radix scutellariae, tealeaves, light
Fruit Radix Glycyrrhizae, Flos Chrysanthemi, rosemary, white willow, spiked gingerlily fruit, Radix Salviae Miltiorrhizae, gentian, loguat leaf, licorice, honeysuckle flowers, marigold and young bird
Chrysanthemum is as major function raw material.Radix scutellariae, Radix Salviae Miltiorrhizae can be clearing heat and detoxicating, have the main bacteria seed killed or inhibit to cause acne infection,
Such as propionibacterium acnes, Radix Salviae Miltiorrhizae, giant knotweed are extremely sensitive to propionibacterium acnes, and radix scutellariae, gentian grass are in propionibacterium acnes
Degree is sensitive, and loguat leaf, Flos Chrysanthemi, marigold and the extract of daisy can be used for treating the more serious illnesss such as swollen, suppuration, bear
Coltsfoot has the effect of broad spectrum antibacterial, clearing heat and detoxicating, wind-heat dissipating.Therefore in the natural Chinese medicinal herb selected of the present invention containing pair
Propionibacterium acnes, golden yellow staphylococcus have the active ingredient of stronger inhibiting effect, can effect a radical cure acne, and prevent from pathogeny
Recurrence, anti-acne effect are good.
(2) in the Whelk-eliminating paste based on high-purity herb extract for preparing of the present invention also containing giant knotweed, saccharomyces cerevisiae and
The extract of grape fruit cell increases skin elasticity, improves the immunity of human body, prevent skin aging, make skin become it is fine and smooth,
It moistens, is glossy, also there is contraction and convergent effect to pore, skin tightening effect is good.
(3) Whelk-eliminating paste based on high-purity herb extract prepared by the present invention selects the natural grass of high extraction high-purity
This extract is used as primary raw material, therefore stable effective ingredients in the Whelk-eliminating paste prepared, and impurity is few, reduces impurity for anti-acne
The influence of cream performance ensure that the continual and steady effect of active ingredient, the effect for the treatment of and daily nursing for acne
Good, stability is high, it is ensured that long-term using effect.
(4) rich in nutrition content in the Whelk-eliminating paste based on high-purity herb extract prepared by the present invention, each ingredient are mutual
Cooperation can reach moisturizing, moisten, whitening, compact, is dry and comfortable, light spot, the multiple efficacies such as anti-inflammatory, and without toxicity, guarantee the quality
Phase is long, long-acting stabilization.
Specific embodiment：
Below in conjunction with specific embodiment, the present invention will be described in detail, herein illustrative examples and explanation of the invention
For explaining the present invention, but it is not as a limitation of the invention.
Embodiment 1：
(1) by weight, by 5 parts of centella, 8 parts of giant knotweed, 3- parts of radix scutellariae, 2 parts of tealeaves, 4 parts of glycyrrhiza glabra, Flos Chrysanthemi
5 parts, 3 parts of rosemary, 5 parts of white willow, 6 parts of spiked gingerlily fruit, 10 parts of Radix Salviae Miltiorrhizae, 5 parts of gentian, 8 parts of loguat leaf, 5 parts of licorice, honeysuckle flowers
4 parts, 3 parts of marigold, 5 parts of daisy natural herbs clean and dry after, cutting is pulverized, and is mixed in proportion, first with
Material is than being 1:8 add in 80% ethanol water, ultrasonic disperse, through 80 DEG C of circumfluence distillation 2h, then again using materials ratio as 1:5 add
Enter 60% ethanol water, filtrate rotary evaporation through 75 DEG C of circumfluence distillation 1h, is concentrated into no alcohol taste, obtained by ultrasonic disperse
Recovery rate is the extracting solution of 80% natural herbs.
(2) the extracting solution centrifuging and taking supernatant for the natural herbs for preparing step (1), is subsequently placed in dry answer
In side's-JD resins, 12h is stood, filters 4h, then the macroreticular resin after absorption is transferred in 80% ethanol water, is stood
It filters, macroreticular resin is taken out, by filtrate rotary evaporation to no alcohol taste, wherein the natural herbs extracting solution purified, group
Divide by weight, include 25 parts of rheum emodin, 15 parts of Chrysophanol, 20 parts of scutelloside, 15 parts of salicin, 20 parts of tanshinone, rough gentian
Bitter 10 parts of glycosides, 15 parts of ursolic acid, 5 parts of glycyrrhizic acid, 5 parts of chlorogenic acid, 15 parts of chrysanthemum flavones, 15 parts of resveratrol, Rosmarinic acid 5
Part.
(3) by weight, by 30 parts of deionized water, 5 parts of butanediol, 4 parts of propylene glycol, 8 parts of glycine betaine, 6 parts of urea, poly-
5 parts of sodium glutamate, 9 parts of isononyl isononanoate, 4 parts of dimethyl silicone polymer, 5 parts of ring five dimethyl silicone polymer, cetearyl alcohol
4 parts of alcohol, 5 parts of cetanol, 4 parts of stearine, 5 parts of PEG-75 distearates, 3 parts of ceteth -20, stearyl alcohol
4 parts of polyethers -20,5 parts of carbomer, 5 parts of allantoin, 3 parts of Laurocapram, 5 parts of tridecanol salicylate, 1 part of menthol,
3 parts of quaternary ammonium salt -73,5 parts of beta glucan, 2 parts of triethanolamine, 3 parts of polyacrylate -13,1 part of Parleam, poly- mountain
- 20 2 parts of pears alcohol ester, 1 part of camphor, 5 parts of 1,2- hexylene glycols, 4 parts of decoyl hydroximic acid, 3 parts of 1,3- propylene glycol, 4 parts of hexylene glycol and perfume
3 parts of mixing of essence, 80 DEG C of heating stirrings are complete to dissolving, purifying prepared by the step of being cooled to 45 DEG C, adding in 30 parts (2) it is natural
Herbaceous plant extracting solution, stirs evenly, and is eventually adding 10 parts of beer yeast extract, 8 parts of grape fruit cell extract, protects
Warm rotary evaporation is in paste, obtains the Whelk-eliminating paste based on high-purity herb extract.
Embodiment 2：
(1) by weight, by 20 parts of centella, 25 parts of giant knotweed, 16 parts of radix scutellariae, 8 parts of tealeaves, 12 parts of glycyrrhiza glabra, mother
10 parts of chrysanthemum, 9 parts of rosemary, 15 parts of white willow, 14 parts of spiked gingerlily fruit, 20 parts of Radix Salviae Miltiorrhizae, 10 parts of gentian, 18 parts of loguat leaf, licorice 9
Part, 19 parts of honeysuckle flowers, 11 parts of marigold, 13 parts of daisy natural herbs clean and dry after, cutting is pulverized, in proportion
Mixing, first using materials ratio as 1:10 add in 95% ethanol waters, ultrasonic disperse, through 100 DEG C of circumfluence distillation 4h, then again with
Materials ratio is 1:6 add in 80% ethanol water, and through 80 DEG C of circumfluence distillation 2h, filtrate rotary evaporation is concentrated for ultrasonic disperse
To no alcohol taste, the extracting solution for the natural herbs that recovery rate is 90% is obtained.
(2) the extracting solution centrifuging and taking supernatant for the natural herbs for preparing step (1), is subsequently placed in dry HPD-
In 750 resins, stand for 24 hours, filter 6h, then the macroreticular resin after absorption is transferred in 90% ethanol water, stand and take out
Filter takes out macroreticular resin, by filtrate rotary evaporation to no alcohol taste, wherein the natural herbs extracting solution purified, component
By weight, it is bitter comprising 50 parts of rheum emodin, 35 parts of Chrysophanol, 30 parts of scutelloside, 25 parts of salicin, 40 parts of tanshinone, rough gentian
15 parts of glycosides, 20 parts of ursolic acid, 10 parts of glycyrrhizic acid, 10 parts of chlorogenic acid, 25 parts of chrysanthemum flavones, 20 parts of resveratrol, Rosmarinic acid 10
Part.
(3) by weight, by 50 parts of deionized water, 8 parts of butanediol, 6 parts of propylene glycol, 12 parts of glycine betaine, 7 parts of urea,
8 parts of polyglutamic acid sodium, 12 parts of isononyl isononanoate, 8 parts of dimethyl silicone polymer, 5-7 parts of ring five dimethyl silicone polymer, spermaceti
It is 8 parts of stearyl alcohol, 7 parts of cetanol, 6 parts of stearine, 9 parts of PEG-75 distearates, 6 parts of ceteth -20, hard
- 20 6 parts of lipidol polyethers, 10 parts of carbomer, 8 parts of allantoin, 4 parts of Laurocapram, 7 parts of tridecanol salicylate, menthol
3 parts, 7 parts of quaternary ammonium salt -73,9 parts of beta glucan, 5 parts of triethanolamine, 7 parts of polyacrylate -13,5 parts of Parleam,
4 parts of polysorbate -20,3 parts of camphor, 12 parts of 1,2- hexylene glycols, 11 parts of decoyl hydroximic acid, 7 parts of 1,3- propylene glycol, hexylene glycol 8
The 7 parts of mixing of part and essence, the purifying that 90 DEG C of heating stirrings are prepared to (2) the step of dissolving completely, be cooled to 50 DEG C, add in 50 parts
Natural herbs extracting solution, stir evenly, be eventually adding 16 parts of beer yeast extract, 15 parts of grape fruit cell carries
Object is taken, heat preservation rotary evaporation obtains the Whelk-eliminating paste based on high-purity herb extract in paste.
Embodiment 3：
(1) by weight, by 10 parts of centella, 13 parts of giant knotweed, 8 parts of radix scutellariae, 6 parts of tealeaves, 8 parts of glycyrrhiza glabra, german chamomile
Spend 8 parts, 6 parts of rosemary, 12 parts of white willow, 11 parts of spiked gingerlily fruit, 14 parts of Radix Salviae Miltiorrhizae, 6 parts of gentian, 12 parts of loguat leaf, 7 parts of licorice,
14 parts of honeysuckle flowers, 6 parts of marigold, 8 parts of daisy natural herbs clean and dry after, cutting is pulverized, and is mixed in proportion,
First using materials ratio as 1:98-10 adds in 85% ethanol water, ultrasonic disperse, through 90 DEG C of circumfluence distillation 3h, then again with
Material is than being 1:5 add in 70% ethanol water, and through 75 DEG C of circumfluence distillation 1.5h, filtrate rotary evaporation is concentrated for ultrasonic disperse
To no alcohol taste, the extracting solution for the natural herbs that recovery rate is 85% is obtained.
(2) the extracting solution centrifuging and taking supernatant for the natural herbs for preparing step (1), is subsequently placed in dry answer
In side's-JD resins, 18h is stood, filters 5h, then the macroreticular resin after absorption is transferred in 85% ethanol water, is stood
It filters, macroreticular resin is taken out, by filtrate rotary evaporation to no alcohol taste, wherein the natural herbs extracting solution purified, group
Divide by weight, include 45 parts of rheum emodin, 25 parts of Chrysophanol, 25 parts of scutelloside, 20 parts of salicin, 30 parts of tanshinone, rough gentian
Bitter 12 parts of glycosides, 18 parts of ursolic acid, 8 parts of glycyrrhizic acid, 6 parts of chlorogenic acid, 20 parts of chrysanthemum flavones, 17 parts of resveratrol, Rosmarinic acid 8
Part.
(3) by weight, by 40 parts of deionized water, 6 parts of butanediol, 5 parts of propylene glycol, 10 parts of glycine betaine, 6 parts of urea,
7 parts of polyglutamic acid sodium, 10 parts of isononyl isononanoate, 6 parts of dimethyl silicone polymer, 6 parts of ring five dimethyl silicone polymer, spermaceti are hard
7 parts of lipidol, 6 parts of cetanol, 5 parts of stearine, 8 parts of PEG-75 distearates, 5 parts of ceteth -20, tristearin
- 20 5 parts of alcohol polyethers, 7 parts of carbomer, 7 parts of allantoin, 3 parts of Laurocapram, 6 parts of tridecanol salicylate, menthol 2
Part, is gathered 5 parts of quaternary ammonium salt -73,8 parts of beta glucan, 3 parts of triethanolamine, 5 parts of polyacrylate -13,4 parts of Parleam
3 parts of sorbitol ester -20,2 parts of camphor, 10 parts of 1,2- hexylene glycols, 8 parts of decoyl hydroximic acid, 6 parts of 1,3- propylene glycol, 5 parts of hexylene glycol
The purifying prepared with 6 parts of mixing of essence, 85 DEG C of heating stirrings to (2) the step of dissolving completely, be cooled to 45 DEG C, add in 40 parts
Natural herbs extracting solution, stirs evenly, and is eventually adding 15 parts of beer yeast extract, 10 parts of grape fruit cell extraction
Object, heat preservation rotary evaporation obtain the Whelk-eliminating paste based on high-purity herb extract in paste.
Embodiment 4：
(1) by weight, by 15 parts of centella, 15 parts of giant knotweed, 15 parts of radix scutellariae, 5 parts of tealeaves, 10 parts of glycyrrhiza glabra, mother
10 parts of chrysanthemum, 5 parts of rosemary, 10 parts of white willow, 10 parts of spiked gingerlily fruit, 20 parts of Radix Salviae Miltiorrhizae, 10 parts of gentian, 15 parts of loguat leaf, licorice 5
Part, 15 parts of honeysuckle flowers, 5 parts of marigold, 10 parts of daisy natural herbs clean and dry after, cutting is pulverized, in proportion
Mixing, first using materials ratio as 1:8 add in 95% ethanol waters, ultrasonic disperse, through 100 DEG C of circumfluence distillation 2h, then again with
Materials ratio is 1:5 add in 80% ethanol water, and through 80 DEG C of circumfluence distillation 1h, filtrate rotary evaporation is concentrated for ultrasonic disperse
To no alcohol taste, the extracting solution for the natural herbs that recovery rate is 87% is obtained.
(2) the extracting solution centrifuging and taking supernatant for the natural herbs for preparing step (1), is subsequently placed in dry answer
In side's-JD resins, 20h is stood, filters 5h, then the macroreticular resin after absorption is transferred in 85% ethanol water, is stood
It filters, macroreticular resin is taken out, by filtrate rotary evaporation to no alcohol taste, wherein the natural herbs extracting solution purified, group
Divide by weight, include 40 parts of rheum emodin, 25 parts of Chrysophanol, 20 parts of scutelloside, 15 parts of salicin, 35 parts of tanshinone, rough gentian
Bitter 11 parts of glycosides, 17 parts of ursolic acid, 8 parts of glycyrrhizic acid, 8 parts of chlorogenic acid, 18 parts of chrysanthemum flavones, 19 parts of resveratrol, Rosmarinic acid 8
Part.
(3) by weight, by 35 parts of deionized water, 6 parts of butanediol, 4 parts of propylene glycol, 9 parts of glycine betaine, 6 parts of urea, poly-
6 parts of sodium glutamate, 10 parts of isononyl isononanoate, 5 parts of dimethyl silicone polymer, 5 parts of ring five dimethyl silicone polymer, cetearyl alcohol
6 parts of alcohol, 6 parts of cetanol, 6 parts of stearine, 7 parts of PEG-75 distearates, 7 parts of ceteth -20, stearyl alcohol
6 parts of polyethers -20,8 parts of carbomer, 6 parts of allantoin, 3 parts of Laurocapram, 6 parts of tridecanol salicylate, 2 parts of menthol,
5 parts of quaternary ammonium salt -73,7 parts of beta glucan, 3 parts of triethanolamine, 6 parts of polyacrylate -13,2 parts of Parleam, poly- mountain
- 20 2 parts of pears alcohol ester, 1 part of camphor, 8 parts of 1,2- hexylene glycols, 7 parts of decoyl hydroximic acid, 5 parts of 1,3- propylene glycol, 4-8 parts of hexylene glycol and
6 parts of mixing of essence, the day of purifying that 83 DEG C of heating stirrings are prepared to (2) the step of dissolving completely, be cooled to 47 DEG C, add in 35 parts
Right herbaceous plant extracting solution, stirs evenly, is eventually adding 12 parts of beer yeast extract, 14 parts of grape fruit cell extraction
Object, heat preservation rotary evaporation obtain the Whelk-eliminating paste based on high-purity herb extract in paste.
Embodiment 5：
(1) by weight, by 9 parts of centella, 15 parts of giant knotweed, 14 parts of radix scutellariae, 5 parts of tealeaves, 8 parts of glycyrrhiza glabra, german chamomile
Spend 7 parts, 6 parts of rosemary, 12 parts of white willow, 11 parts of spiked gingerlily fruit, 15 parts of Radix Salviae Miltiorrhizae, 8 parts of gentian, 13 parts of loguat leaf, 6 parts of licorice,
15 parts of honeysuckle flowers, 8 parts of marigold, 7 parts of daisy natural herbs clean and dry after, cutting is pulverized, and is mixed in proportion,
First using materials ratio as 1:10 add in 90% ethanol water, ultrasonic disperse, through 90 DEG C of circumfluence distillation 4h, then again with materials ratio
It is 1:6 add in 7% ethanol water, and ultrasonic disperse, through 75 DEG C of circumfluence distillation 1.5h, rotary evaporation is concentrated into no alcohol taste, obtains
To the extracting solution for the natural herbs that recovery rate is 82.
(2) the extracting solution centrifuging and taking supernatant for the natural herbs for preparing step (1), is subsequently placed in dry answer
In side's-JD resins, 12h is stood, filters 4h, then the macroreticular resin after absorption is transferred in 90% ethanol water, is stood
It filters, macroreticular resin is taken out, by filtrate rotary evaporation to no alcohol taste, wherein the natural herbs extracting solution purified, group
Divide by weight, it is bitter to include 35 parts of rheum emodin, yellow 20 parts of phenol, 20 parts of scutelloside, 20 parts of salicin, 30 parts of tanshinone, rough gentian
11 parts of glycosides, 17 parts of ursolic acid, 7 parts of glycyrrhizic acid, 8 parts of chlorogenic acid, 17 parts of chrysanthemum flavones, 17 parts of resveratrol, 7 parts of Rosmarinic acid.
(3) by weight, by 40 parts of deionized water, 5 parts of butanediol, 4 parts of propylene glycol, 8 parts of glycine betaine, 7 parts of urea, poly-
5 parts of sodium glutamate, 12 parts of isononyl isononanoate, 4 parts of dimethyl silicone polymer, 7 parts of ring five dimethyl silicone polymer, cetearyl alcohol
4 parts of alcohol, 7 parts of cetanol, 6 parts of stearine, 5 parts of PEG-75 distearates, 6 parts of ceteth -20, stearyl alcohol
4 parts of polyethers -20,10 parts of carbomer, 5 parts of allantoin, 4 parts of Laurocapram, 5 parts of tridecanol salicylate, 3 parts of menthol,
3 parts of quaternary ammonium salt -73,9 parts of beta glucan, 5 parts of triethanolamine, 3 parts of polyacrylate -13,1 part of Parleam, poly- mountain
- 20 2 parts of pears alcohol ester, 3 parts of camphor, 12 parts of 1,2- hexylene glycols, 11 parts of decoyl hydroximic acid, 3 parts of 1,3- propylene glycol, 4 parts of hexylene glycol and
3 parts of mixing of essence, the day of purifying that 90 DEG C of heating stirrings are prepared to (2) the step of dissolving completely, be cooled to 45 DEG C, add in 50 parts
Right herbaceous plant extracting solution, stirs evenly, is eventually adding 16 parts of beer yeast extract, 8 parts of grape fruit cell extract,
Rotary evaporation is kept the temperature in paste, obtains the Whelk-eliminating paste based on high-purity herb extract.
Embodiment 6：
(1) by weight, by 20 parts of centella, 25 parts of giant knotweed, 3 parts of radix scutellariae, 2 parts of tealeaves, 12 parts of glycyrrhiza glabra, german chamomile
Spend 10 parts, 3 parts of rosemary, 15 parts of white willow, 6 parts of spiked gingerlily fruit, 20 parts of Radix Salviae Miltiorrhizae, 5 parts of gentian, 18 parts of loguat leaf, 9 parts of licorice,
19 parts of honeysuckle flowers, 3 parts of marigold, 5 parts of daisy natural herbs clean and dry after, cutting is pulverized, and is mixed in proportion,
First using materials ratio as 1：10 add in 95% ethanol water, ultrasonic disperse, through 100 DEG C of circumfluence distillation 2h, then again with materials
Than being 1:6 add in 80% ethanol water, and filtrate rotary evaporation through 75 DEG C of circumfluence distillation 2h, is concentrated into nothing by ultrasonic disperse
Alcohol taste obtains the extracting solution for the natural herbs that recovery rate is 87%.
(2) the extracting solution centrifuging and taking supernatant for the natural herbs for preparing step (1), is subsequently placed in dry HPD-
In 750 resins, stand for 24 hours, filter 4h, then the macroreticular resin after absorption is transferred in 90% ethanol water, stand and take out
Filter takes out macroreticular resin, by filtrate rotary evaporation to no alcohol taste, wherein the natural herbs extracting solution purified, component
By weight, it is bitter comprising 50 parts of rheum emodin, 30 parts of Chrysophanol, 25 parts of scutelloside, 15 parts of salicin, 40 parts of tanshinone, rough gentian
15 parts of glycosides, 15 parts of ursolic acid, 10 parts of glycyrrhizic acid, 10 parts of chlorogenic acid, 25 parts of chrysanthemum flavones, 15 parts of resveratrol, Rosmarinic acid 10
Part.
(3) by weight, by 50 parts of deionized water, 5 parts of butanediol, 6 parts of propylene glycol, 12 parts of glycine betaine, 6 parts of urea,
5 parts of polyglutamic acid sodium, 12 parts of isononyl isononanoate, 8 parts of dimethyl silicone polymer, 5 parts of ring five dimethyl silicone polymer, spermaceti are hard
4 parts of lipidol, 5 parts of cetanol, 6 parts of stearine, 9 parts of PEG-75 distearates, 6 parts of ceteth -20, tristearin
- 20 4 parts of alcohol polyethers, 5 parts of carbomer, 5 parts of allantoin, 3 parts of Laurocapram, 5 parts of tridecanol salicylate, menthol 1
Part, 3 parts of quaternary ammonium salt -73,5 parts of beta glucan, 2 parts of triethanolamine, 3 parts of polyacrylate -13,1-5 parts of Parleam,
- 20 2-4 parts of polysorbate, 1-3 parts of camphor, 5-12 parts of 1,2- hexylene glycols, 4 parts of decoyl hydroximic acid, 3 parts of 1,3- propylene glycol, oneself
It is prepared by the 3 parts of mixing of 4 parts of glycol and essence, 80 DEG C of heating stirrings to (2) the step of dissolving completely, be cooled to 50 DEG C, add in 50 parts
Purifying natural herbs extracting solution, stir evenly, be eventually adding 10 parts beer yeast extract, 8 parts of grape fruit
Cell extract, heat preservation rotary evaporation obtain the Whelk-eliminating paste based on high-purity herb extract in paste.
After testing, it is the safety of the Whelk-eliminating paste based on high-purity herb extract that prepared by embodiment 1-6, stability, anti-
Bacterium property, and using whitening after 30 days, light spot and acne it is treated effect as a result, as shown in the table：
Also, the anti-acne based on high-purity herb extract that the teenager of 10-20 Sui is selected to be prepared using embodiment 1-6
Cream is compared for 30 days with not used, the sebum secretion amount variation of test and the following institute of result of the variation of acne lesions quantity
Show：
As seen from the above table, the Whelk-eliminating paste performance based on high-purity herb extract that prepared by the present invention is stablized, and is used for a long time
It is good to acne treatment effect, but also the effect of have both whitening, moisturizing, light spot.
The above-described embodiments merely illustrate the principles and effects of the present invention, and is not intended to limit the present invention.It is any ripe
The personage for knowing this technology all can carry out modifications and changes under the spirit and scope without prejudice to the present invention to above-described embodiment.Cause
This, those of ordinary skill in the art is complete without departing from disclosed spirit and institute under technological thought such as
Into all equivalent modifications or change, should by the present invention claim be covered.
Claims (7)
1. a kind of Whelk-eliminating paste based on high-purity herb extract, which is characterized in that the active constituent of the Whelk-eliminating paste has following
Natural herb extract by weight ratio is formed：Centella 5-20, giant knotweed 8-25, radix scutellariae 3-16, tealeaves 2-8, light fruit are sweet
Careless 4-12, Flos Chrysanthemi 5-10, rosemary 3-9, white willow 5-15, spiked gingerlily fruit 6-14, Radix Salviae Miltiorrhizae 10-20, gentian 5-10, loguat leaf 8-
18th, licorice 5-9, honeysuckle flowers 4-19, marigold 3-11, daisy 5-13, the recovery rate of the natural herb extract are higher than
80%, the purity of the natural herb extract is higher than 87%；
Also containing beer yeast extract, grape fruit cell extract and auxiliary agent in the Whelk-eliminating paste, auxiliary agent in the Whelk-eliminating paste
Including：Deionized water, butanediol, propylene glycol, glycine betaine, urea, polyglutamic acid sodium, isononyl isononanoate, polydimethylsiloxanes
Alkane, ring five dimethyl silicone polymer, cetostearyl alcohol, cetanol, stearine, PEG-75 distearates, cetanol
Polyethers -20, stereth -20, carbomer, allantoin, Laurocapram, tridecanol salicylate, menthol, quaternary ammonium
Salt -73, beta glucan, triethanolamine, polyacrylate -13, Parleam, polysorbate -20, camphor, 1,2- oneself
Glycol, decoyl hydroximic acid, 1,3- propylene glycol, hexylene glycol and essence.
2. a kind of preparation method of Whelk-eliminating paste based on high-purity herb extract according to claim 1, feature exist
In：Include the following steps：
(1) above-mentioned natural herbs are cleaned after drying, cutting is pulverized, and is mixed according to the above ratio, and it is water-soluble to add in ethyl alcohol
Filtrate rotary evaporation through circumfluence distillation 2 times, is concentrated into no alcohol taste, obtains the extraction of natural herbs by liquid, ultrasonic disperse
Liquid；
(2) the extracting solution centrifuging and taking supernatant for the natural herbs for preparing step (1), is subsequently placed in dry macroreticular resin
In, it stands and filters, then the macroreticular resin after absorption is transferred in the ethanol water of 80-90%, stand and filter, take out macropore
Resin, by filtrate rotary evaporation to no alcohol taste, the natural herbs extracting solution purified；
(3) above-mentioned auxiliary agent is mixed, 80-90 DEG C of heating stirring is complete to dissolving, and is cooled to 45-50 DEG C, adds in step (2) and prepares
Purifying natural herbs extracting solution, stir evenly, be eventually adding beer yeast extract, grape fruit cell extract,
Rotary evaporation is kept the temperature in paste, obtains the Whelk-eliminating paste based on high-purity herb extract.
3. a kind of preparation method of Whelk-eliminating paste based on high-purity herb extract according to claim 2, feature exist
In：In the step (1), the first time of circumfluence distillation：A concentration of 80-95% of ethanol water, materials ratio are 1:8-10,
Temperature is 80-100 DEG C, extraction time 2-4h, second of circumfluence distillation：A concentration of 60-80% of ethanol water is used
Material is than being 1:5-6, temperature are 75-80 DEG C, extraction time 1-2h.
4. a kind of preparation method of Whelk-eliminating paste based on high-purity herb extract according to claim 2, feature exist
In：In the step (1), the recovery rate of active ingredient is 80-90% in the extracting solution of natural herbs.
5. a kind of preparation method of Whelk-eliminating paste based on high-purity herb extract according to claim 2, feature exist
In：In the step (2), dry macroreticular resin is compound-JD resins and HPD-750 resins.
6. a kind of preparation method of Whelk-eliminating paste based on high-purity herb extract according to claim 2, feature exist
In：In the step (2), the time of standing is 12-24h, filters 4-6h.
7. a kind of preparation method of Whelk-eliminating paste based on high-purity herb extract according to claim 2, feature exist
In：In the step (2), the ingredient in the natural herbs extracting solution of purifying by weight, includes rheum emodin 25-50
Part, 15-35 parts of Chrysophanol, 20-30 parts of scutelloside, 15-25 parts of salicin, 20-40 parts of tanshinone, 10-15 parts of gentiamarin, bear
15-20 parts of tartaric acid, 5-10 parts of glycyrrhizic acid, 5-10 parts of chlorogenic acid, 15-25 parts of chrysanthemum flavones, 15-20 parts of resveratrol, rosemary
It is 5-10 parts sour.
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| CN106473944B (en) * | 2016-12-15 | 2019-07-02 | 广东科玮生物技术股份有限公司 | A kind of acne-removing composition and acne eliminating cream containing antibacterial peptide |
| CN106726689A (en) * | 2016-12-24 | 2017-05-31 | 叶宗瑞 | It is a kind of to prevent and treat face cream of acne and preparation method thereof |
| CN108553356A (en) * | 2018-05-17 | 2018-09-21 | 广州兰若坊生物科技有限公司 | A kind of compound Chinese herb toxin expelling anti-acne essence composition |
| CN108703912B (en) * | 2018-08-10 | 2022-02-22 | 广州华玺生物科技有限公司 | A herba Centellae total flavone extract, and its preparation method and application in cosmetics |
| CN115054561A (en) * | 2022-07-22 | 2022-09-16 | 中植(山东)生物技术有限责任公司 | Compound plant extract with acne removing effect and preparation method thereof |
| CN117064821B (en) * | 2023-10-16 | 2023-12-19 | 宝萃生物科技有限公司 | Oil control and/or acne removal composition, and preparation and application thereof |
| CN117064822B (en) * | 2023-10-16 | 2023-12-12 | 广州市中通生化制品有限公司 | Plant acne-removing composition, plant acne-removing patch and preparation method of plant acne-removing composition |
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Inventor after: Wang Wenqing Inventor before: Hu Haiwei Inventor before: Ding Jing Inventor before: Yan Yongping Inventor before: Zheng Hui Inventor before: Yan Hui |
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Effective date of registration: 20180208 Address after: 2, building 523000, building 11, Songshan hi tech Industrial Development Zone, Songshan Lake, Guangdong, Dongguan Applicant after: Dongguan Jia Xin new Mstar Technology Ltd Address before: 215000 room A, No. 2, Taishan Road, Suzhou high tech Zone, Jiangsu Province, room 307 Applicant before: Suzhou ITIC MedChem Co.,Ltd. |
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Effective date of registration: 20190122 Address after: 510470 Third Industrial Zone of Renzhen Aigang Village, Baiyun District, Guangzhou City, Guangdong Province Patentee after: Baicaotang pharmaceutical Limited by Share Ltd Address before: 523000, 2, building 11, innovation and Technology Park, Songshan Lake high tech Industrial Development Zone, Dongguan, Guangdong Patentee before: Dongguan Jia Xin new Mstar Technology Ltd |