CN105662962A

CN105662962A - Anti-acne cream based on high-purity herbal extract, and preparation method of anti-acne cream

Info

Publication number: CN105662962A
Application number: CN201610112859.0A
Authority: CN
Inventors: 胡海威; 丁靓; 闫永平; 郑辉; 严辉
Original assignee: SUZHOU ITIC MEDCHEM CO Ltd
Current assignee: Baicaotang pharmaceutical Limited by Share Ltd
Priority date: 2016-03-01
Filing date: 2016-03-01
Publication date: 2016-06-15
Anticipated expiration: 2036-03-01
Also published as: CN105662962B

Abstract

The invention provides anti-acne cream based on high-purity herbal extract, and a preparation method of the anti-acne cream. The preparation method concretely comprises the following steps: (1) cleaning natural herbaceous plants, drying the cleaned herbaceous plants in the air, then cutting the dried herbaceous plants and grinding into powder, mixing the powder of the herbaceous plants according to proportion, adding an ethanol water solution into the mixture, carrying out ultrasonic dispersion, carrying out heat reflux extraction for twice, and carrying out rotary evaporation and concentration on filtrate until the filtrate is free from alcohol taste to obtain extract of the natural herbaceous plants; (2) centrifuging the extract of the natural herbaceous plants and taking supernatant of the extract, putting the supernatant into dry macroporous resin, standing still and carrying out suction filtration; after absorption, transferring the macroporous resin into a 80-90% of ethanol water solution, standing still and carrying out suction filtration; taking out the macroporous resin, carrying out rotary evaporation on filtrate until the filtrate is free from alcohol taste to obtain purified extract of the natural herbaceous plants; (3) mixing auxiliary agents, heating mixture up to 80-90 DEG C, stirring the heated mixture until the mixture is completely dissolved, cooling to 45-50 DEG C, adding the purified extract of the natural herbaceous plants into the mixture, evenly stirring, carrying out heat preservation, and then carrying out rotary evaporation until the mixture is in a cream state to obtain the anti-acne cream based on the high-purity herbal extract.

Description

A kind of Whelk-eliminating paste based on high-purity herb extract and preparation method thereof

Technical field:

The invention belongs to daily cosmetics technical field, be specifically related to a kind of Whelk-eliminating paste based on high-purity herb extract and preparation method thereof.

Background technology:

Acne, also referred to as comedo, skin sore and acne, it is betide pilosebaceous a kind of chronic inflammatory diseases, takes place mostly in face and the back of adolescence and manhood youth of both sexes, deal with improperly and can leave leprosy trace, have a strong impact on the fine hair of people, employment, social activity and marriage and childbirth etc. Acne is relevant with factors such as androgen levels rising, sebum secretion increase, hair follicle conduit hyperkeratosis, propionibacterium infection, traditional treatment skill needs to use antibiotic, androgen antagonist, tretinoin medicines to treat, but toxic and side effects is obvious. Along with improving constantly of people's living standard, people increasingly focus on the feature of environmental protection of cosmetics of everyday use, safety and natural sex, and therefore the acne species cosmetics based on Chinese medicine ingredients are increasingly becoming focus.

Current cosmetics science and technology content is relatively low, and its raw material adopted is mostly chemical substance, can cause serious toxic and side effects and anaphylaxis. Treatment for acne, describing the multiple Chinese medicine with heat-clearing and toxic substances removing cooling blood, expelling wind in successive dynasties medical book, such Chinese medicine can directly act on the surface with acne pathogens, stops the process of inflammation, reach anti-acne or improve the purpose of acne symptom, and instant effect, side effect are little.

Disclosed a kind of beauty treatment acne-removing composition of Chinese patent CN101502588B (publication date 2009.8.12) and preparation method thereof, it is made up of following raw material: Radix Rehmanniae, Folium Eriobotryae, Cortex Moutan, Fructus Gardeniae, Radix Paeoniae Rubra, Radix Scutellariae, Cortex Mori, Radix Glycyrrhizae, this beauty treatment acne-removing composition can be made into dosage form for oral administration, to the effective percentage of the treatment of comedo up to 98%, skin exquisiteness can also be made delicate, high resilience. A kind of cosmetic composition with acne-removal function disclosed in Chinese patent CN103432024B (publication date 2013.12.11), the active component of this cosmetic composition includes Radix Scutellariae, Flos Chrysanthemi Indici, Flos Lonicerae, Fructus Gardeniae, Cortex Moutan and Radix Paeoniae Rubra, prepare the cosmetics that easy natural herbs is primary raw material, and test through function assessment, there is antibacterial and antiinflammatory effect.The disclosed a kind of gentle effective removing acnes and controlling oil composition and method of making the same of Chinese patent CN104188849A (publication date 2014.12.10), this removing acnes and controlling oil compositions includes ABC component, component A is deionized water, hyaluronate sodium, glycerol, propylene glycol, hydroxyethyl cellulose and allantoin, B component is D-panthenol, white willow peel extract, zinc paraphenol sulfonate, Herba portulacae extract, component C is preservative, essence and Cremophor RH40, acne-removing composition prepared by the present invention is rationally composite by tri-kinds of components of ABC, possesses moisturizing, adjustment oils and fats balances, the multi-efficiency such as antiinflammatory and anti-acne, colleague can improve the cure rate of acne, it is free from side effects.

From above-mentioned prior art, there is the Chinese medicine composition of heat-clearing and toxic substances removing cooling blood, expelling wind as functional raw material, the compositions that obtain there is acne-removal function composite with other raw materials, but the purity requirement of Chinese medicine ingredients is not common in combining for anti-acne, the limited efficacy of the anti-acne combination therefore prepared, effect is floated also relatively big, unstable properties.

Summary of the invention:

The technical problem to be solved in the present invention is to provide a kind of Whelk-eliminating paste based on high-purity herb extract and preparation method thereof, the present invention is according to theory of Chinese medical science, select Herba Centellae, Rhizoma Polygoni Cuspidati, Radix Scutellariae, Folium Camelliae sinensis, Glycyrrhiza glabra L., Flos Chrysanthemi, Herba Rosmarini Officinalis, Salix alba, Fructus Hedychii Spicati, Radix Salviae Miltiorrhizae, root of Gentiana lutea, Folium Eriobotryae, licorice, Flos Lonicerae, Flos Tagetis Erectae and Bellis perennis be as major function raw material, separate the extracting solution obtaining the highly purified natural herbs of high extraction through reflux, extract, with macroporous resin, form the Whelk-eliminating paste based on high-purity herb extract by adding other auxiliary agents. The present invention prepare based in the Whelk-eliminating paste of high-purity herb extract containing multiple effective active composition, have heat clearing and damp drying, effect swollen, blood circulation promoting and blood stasis dispelling, Whitening, spot is dispelled in eliminating fire and detoxication, antiinflammatory, functional good, and make the stability of Whelk-eliminating paste, safety, guaranteeing the quality property good by adding auxiliary agent.

For solving above-mentioned technical problem, the technical scheme is that

A kind of Whelk-eliminating paste based on high-purity herb extract, it is characterized in that, the active component of described Whelk-eliminating paste has following natural herb extract by weight ratio to constitute: Herba Centellae 5-20, Rhizoma Polygoni Cuspidati 8-25, Radix Scutellariae 3-16, Folium Camelliae sinensis 2-8, Glycyrrhiza glabra L. 4-12, Flos Chrysanthemi 5-10, Herba Rosmarini Officinalis 3-9, Salix alba 5-15, Fructus Hedychii Spicati 6-14, Radix Salviae Miltiorrhizae 10-20, root of Gentiana lutea 5-10, Folium Eriobotryae 8-18, licorice 5-9, Flos Lonicerae 4-19, Flos Tagetis Erectae 3-11, Bellis perennis 5-13.

Preferably, the extraction ratio of described natural herb extract is higher than 80%, and the purity of described natural herb extract is higher than 87%.

Preferably, possibly together with beer yeast extract, uva cell extract and auxiliary agent in described Whelk-eliminating paste.

Preferably, in described Whelk-eliminating paste, auxiliary agent includes: deionized water, butanediol, propylene glycol, glycine betaine, carbamide, polyglutamic acid sodium, isononyl isononanoate, polydimethylsiloxane, ring five polydimethylsiloxane, cetearyl alcohol, spermol, glyceryl stearate, PEG-75 distearate, ceteth-20, stereth-20, carbomer, allantoin, laurocapram, tridecyl alcohol salicylate, Mentholum, quaternary ammonium salt-73, beta glucan, triethanolamine, polyacrylate-13, Parleam, polysorbate-20, Camphora, 1, 2-hexanediol, decoyl hydroximic acid, 1, ammediol, hexanediol and essence.

The preparation method that the present invention also provides for a kind of Whelk-eliminating paste based on high-purity herb extract, it is characterised in that: comprise the following steps:

(1), after being cleaned by above-mentioned natural herbs and drying, cutting is pulverized, and mixes according to the above ratio, adds ethanol water, ultrasonic disperse, through circumfluence distillation 2 times, is concentrated into filtrate rotary evaporation without alcohol taste, obtains the extracting solution of natural herbs;

(2) the extracting solution centrifuging and taking supernatant of natural herbs prepared by step (1), it is subsequently placed in dry macroporous resin, stand sucking filtration, again the macroporous resin after absorption is transferred in the ethanol water of 80-90%, stand sucking filtration, take out macroporous resin, by filtrate rotary evaporation to without alcohol taste, obtaining the natural herbs extracting solution of purification;

(3) above-mentioned auxiliary agent is mixed, 80-90 DEG C of heated and stirred is to dissolving completely, it is cooled to 45-50 DEG C, add the natural herbs extracting solution of purification prepared by step (2), stir, being eventually adding beer yeast extract, uva cell extract, insulation rotary evaporation is paste, obtains the Whelk-eliminating paste based on high-purity herb extract.

Preferred as technique scheme, in described step (1), the first time of circumfluence distillation: the concentration of ethanol water is 80-95%, materials are than for 1:8-10, and temperature is 80-100 DEG C, and extraction time is 2-4h, the second time of circumfluence distillation: the concentration of ethanol water is 60-80%, materials are than for 1:5-6, and temperature is 75-80 DEG C, and extraction time is 1-2h.

Preferred as technique scheme, in described step (1), in the extracting solution of natural herbs, the extraction ratio of effective ingredient is 80-90%.

Preferred as technique scheme, in described step (2), dry macroporous resin is compound recipe-JD resin and HPD-750 resin.

Preferred as technique scheme, in described step (2), the time of standing is 12-24h, sucking filtration 4-6h.

Preferred as technique scheme, in described step (2), composition in the natural herbs extracting solution of purification, by weight, rheum emodin 25-50 part, chrysophanol 15-35 part, baicalin 20-30 part, salicin 15-25 part, TANSHINONES 20-40 part, gentiopicrin 10-15 part, ursolic acid 15-20 part, glycyrrhizic acid 5-10 part, chlorogenic acid 5-10 part, Flos Chrysanthemi flavone 15-25 part, resveratrol 15-20 part, rosmarinic acid 5-10 part are comprised.

Compared with prior art, the method have the advantages that

(1) present invention is based on theory of Chinese medical science, for the pathogeny of acne, select Herba Centellae, Rhizoma Polygoni Cuspidati, Radix Scutellariae, Folium Camelliae sinensis, Glycyrrhiza glabra L., Flos Chrysanthemi, Herba Rosmarini Officinalis, Salix alba, Fructus Hedychii Spicati, Radix Salviae Miltiorrhizae, root of Gentiana lutea, Folium Eriobotryae, licorice, Flos Lonicerae, Flos Tagetis Erectae and Bellis perennis be as major function raw material. Radix Scutellariae, Radix Salviae Miltiorrhizae can heat-clearing and toxic substances removing, there is killing or suppress to cause the main bacteria seed of acne infection, such as propionibacterium acnes, Radix Salviae Miltiorrhizae, Rhizoma Polygoni Cuspidati are extremely sensitive to propionibacterium acnes, Radix Scutellariae, HUANGLONG Radix Gentianae are to propionibacterium acnes medium sensitivity, the extract of Folium Eriobotryae, Flos Chrysanthemi, Flos Tagetis Erectae and Bellis perennis may be used for treating disease swollen, that suppuration geometric ratio is more serious, and Flos Lonicerae has a broad spectrum antibacterial, heat-clearing and toxic substances removing, wind-heat dissipating effect. Therefore having stronger inhibiting effective ingredient containing to propionibacterium acnes, golden yellow staphylococcus in the natural Chinese medicinal herb that the present invention selects, can effect a radical cure acne from source of disease, and prevent recurrence, anti-acne effect is good.

(2) present invention prepare based in the Whelk-eliminating paste of high-purity herb extract possibly together with the extract of Rhizoma Polygoni Cuspidati, cereuisiae fermentum and uva cell, increase skin elasticity, improve the immunity of human body, prevent skin aging, skin is made to become fine and smooth, moistening, glossy, pore also has the effect shunk and restrain, and skin tightening effect is good.

(3) Whelk-eliminating paste based on high-purity herb extract prepared by the present invention selects the highly purified natural herb extract of high extraction as primary raw material, therefore stable effective ingredients in the Whelk-eliminating paste prepared, impurity is few, decrease the impurity impact for Whelk-eliminating paste performance, ensure that the continual and steady effect of effective ingredient, effective for the treatment of acne and daily nursing, stability is high, it is ensured that long-term result of use.

(4) the Whelk-eliminating paste Middle nutrition composition based on high-purity herb extract prepared by the present invention enriches, each composition cooperates can reach moisturizing, moisten, whitening, compact, speckle dry and comfortable, light, the multiple efficacies such as antiinflammatory, and without toxicity, long shelf-life, long-acting stable.

Detailed description of the invention:

Describing the present invention in detail below in conjunction with specific embodiment, illustrative examples and explanation in this present invention are used for explaining the present invention, but not as a limitation of the invention.

Embodiment 1:

(1) by weight, by Herba Centellae 5 parts, Rhizoma Polygoni Cuspidati 8 parts, Radix Scutellariae 3-part, Folium Camelliae sinensis 2 parts, Glycyrrhiza glabra L. 4 parts, Flos Chrysanthemi 5 parts, Herba Rosmarini Officinalis 3 parts, Salix alba 5 parts, Fructus Hedychii Spicati 6 parts, Radix Salviae Miltiorrhizae 10 parts, root of Gentiana lutea 5 parts, Folium Eriobotryae 8 parts, licorice 5 parts, Flos Lonicerae 4 parts, Flos Tagetis Erectae 3 parts, the natural herbs that Bellis perennis is 5 parts is cleaned after drying, cutting is pulverized, it is mixed in proportion, first add 80% ethanol water with materials than for 1:8, ultrasonic disperse, through 80 DEG C of circumfluence distillation 2h, then 60% ethanol water is added with materials than for 1:5 again, ultrasonic disperse, through 75 DEG C of circumfluence distillation 1h, filtrate rotary evaporation is concentrated into without alcohol taste, obtain the extracting solution of the natural herbs that extraction ratio is 80%.

(2) the extracting solution centrifuging and taking supernatant of natural herbs prepared by step (1), it is subsequently placed in dry compound recipe-JD resin, stand 12h, sucking filtration 4h, again the macroporous resin after absorption is transferred in the ethanol water of 80%, stand sucking filtration, take out macroporous resin, by filtrate rotary evaporation to without alcohol taste, obtain the natural herbs extracting solution of purification, wherein component is by weight, comprise rheum emodin 25 parts, chrysophanol 15 parts, baicalin 20 parts, salicin 15 parts, TANSHINONES 20 parts, gentiopicrin 10 parts, ursolic acid 15 parts, glycyrrhizic acid 5 parts, chlorogenic acid 5 parts, Flos Chrysanthemi flavone 15 parts, resveratrol 15 parts, rosmarinic acid 5 parts.

(3) by weight, by deionized water 30 parts, butanediol 5 parts, propylene glycol 4 parts, glycine betaine 8 parts, 6 parts of carbamide, 5 parts of polyglutamic acid sodium, isononyl isononanoate 9 parts, polydimethylsiloxane 4 parts, ring five polydimethylsiloxane 5 parts, cetearyl alcohol 4 parts, spermol 5 parts, glyceryl stearate 4 parts, PEG-75 distearate 5 parts, ceteth-203 parts, stereth-204 parts, carbomer 5 parts, allantoin 5 parts, laurocapram 3 parts, tridecyl alcohol salicylate 5 parts, Mentholum 1 part, quaternary ammonium salt-733 parts, beta glucan 5 parts, triethanolamine 2 parts, polyacrylate-133 parts, Parleam 1 part, polysorbate-202 parts, Camphora 1 part, 1,2-hexanediol 5 parts, decoyl hydroximic acid 4 parts, 1,3-propylene glycol 3 parts, hexanediol 4 parts and the mixing of 3 parts of essence, 80 DEG C of heated and stirred are complete to dissolving, and are cooled to 45 DEG C, add the natural herbs extracting solution of purification prepared by the step (2) of 30 parts, stir, be eventually adding the beer yeast extract of 10 parts, the uva cell extract of 8 parts, insulation rotary evaporation is paste, obtains the Whelk-eliminating paste based on high-purity herb extract.

Embodiment 2:

(1) by weight, by Herba Centellae 20 parts, Rhizoma Polygoni Cuspidati 25 parts, Radix Scutellariae 16 parts, Folium Camelliae sinensis 8 parts, Glycyrrhiza glabra L. 12 parts, Flos Chrysanthemi 10 parts, Herba Rosmarini Officinalis 9 parts, Salix alba 15 parts, Fructus Hedychii Spicati 14 parts, Radix Salviae Miltiorrhizae 20 parts, root of Gentiana lutea 10 parts, Folium Eriobotryae 18 parts, licorice 9 parts, Flos Lonicerae 19 parts, Flos Tagetis Erectae 11 parts, the natural herbs that Bellis perennis is 13 parts is cleaned after drying, cutting is pulverized, it is mixed in proportion, first add 95% ethanol water with materials than for 1:10, ultrasonic disperse, through 100 DEG C of circumfluence distillation 4h, then 80% ethanol water is added with materials than for 1:6 again, ultrasonic disperse, through 80 DEG C of circumfluence distillation 2h, filtrate rotary evaporation is concentrated into without alcohol taste, obtain the extracting solution of the natural herbs that extraction ratio is 90%.

(2) the extracting solution centrifuging and taking supernatant of natural herbs prepared by step (1), it is subsequently placed in dry HPD-750 resin, stand 24h, sucking filtration 6h, again the macroporous resin after absorption is transferred in the ethanol water of 90%, stand sucking filtration, take out macroporous resin, by filtrate rotary evaporation to without alcohol taste, obtain the natural herbs extracting solution of purification, wherein component is by weight, comprise rheum emodin 50 parts, chrysophanol 35 parts, baicalin 30 parts, salicin 25 parts, TANSHINONES 40 parts, gentiopicrin 15 parts, ursolic acid 20 parts, glycyrrhizic acid 10 parts, chlorogenic acid 10 parts, Flos Chrysanthemi flavone 25 parts, resveratrol 20 parts, rosmarinic acid 10 parts.

(3) by weight, by deionized water 50 parts, butanediol 8 parts, propylene glycol 6 parts, glycine betaine 12 parts, 7 parts of carbamide, 8 parts of polyglutamic acid sodium, isononyl isononanoate 12 parts, polydimethylsiloxane 8 parts, ring five polydimethylsiloxane 5-7 part, cetearyl alcohol 8 parts, spermol 7 parts, glyceryl stearate 6 parts, PEG-75 distearate 9 parts, ceteth-206 parts, stereth-206 parts, carbomer 10 parts, allantoin 8 parts, laurocapram 4 parts, tridecyl alcohol salicylate 7 parts, Mentholum 3 parts, quaternary ammonium salt-737 parts, beta glucan 9 parts, triethanolamine 5 parts, polyacrylate-137 parts, Parleam 5 parts, polysorbate-204 parts, Camphora 3 parts, 1,2-hexanediol 12 parts, decoyl hydroximic acid 11 parts, 1,3-propylene glycol 7 parts, hexanediol 8 parts and the mixing of 7 parts of essence, 90 DEG C of heated and stirred are complete to dissolving, and are cooled to 50 DEG C, add the natural herbs extracting solution of purification prepared by the step (2) of 50 parts, stir, be eventually adding the beer yeast extract of 16 parts, the uva cell extract of 15 parts, insulation rotary evaporation is paste, obtains the Whelk-eliminating paste based on high-purity herb extract.

Embodiment 3:

(1) by weight, by Herba Centellae 10 parts, Rhizoma Polygoni Cuspidati 13 parts, Radix Scutellariae 8 parts, Folium Camelliae sinensis 6 parts, Glycyrrhiza glabra L. 8 parts, Flos Chrysanthemi 8 parts, Herba Rosmarini Officinalis 6 parts, Salix alba 12 parts, Fructus Hedychii Spicati 11 parts, Radix Salviae Miltiorrhizae 14 parts, root of Gentiana lutea 6 parts, Folium Eriobotryae 12 parts, licorice 7 parts, Flos Lonicerae 14 parts, Flos Tagetis Erectae 6 parts, the natural herbs that Bellis perennis is 8 parts is cleaned after drying, cutting is pulverized, it is mixed in proportion, first add 85% ethanol water with materials than for 1:98-10, ultrasonic disperse, through 90 DEG C of circumfluence distillation 3h, then 70% ethanol water is added with materials than for 1:5 again, ultrasonic disperse, through 75 DEG C of circumfluence distillation 1.5h, filtrate rotary evaporation is concentrated into without alcohol taste, obtain the extracting solution of the natural herbs that extraction ratio is 85%.

(2) the extracting solution centrifuging and taking supernatant of natural herbs prepared by step (1), it is subsequently placed in dry compound recipe-JD resin, stand 18h, sucking filtration 5h, again the macroporous resin after absorption is transferred in the ethanol water of 85%, stand sucking filtration, take out macroporous resin, by filtrate rotary evaporation to without alcohol taste, obtain the natural herbs extracting solution of purification, wherein component is by weight, comprise rheum emodin 45 parts, chrysophanol 25 parts, baicalin 25 parts, salicin 20 parts, TANSHINONES 30 parts, gentiopicrin 12 parts, ursolic acid 18 parts, glycyrrhizic acid 8 parts, chlorogenic acid 6 parts, Flos Chrysanthemi flavone 20 parts, resveratrol 17 parts, rosmarinic acid 8 parts.

(3) by weight, by deionized water 40 parts, butanediol 6 parts, propylene glycol 5 parts, glycine betaine 10 parts, 6 parts of carbamide, 7 parts of polyglutamic acid sodium, isononyl isononanoate 10 parts, polydimethylsiloxane 6 parts, ring five polydimethylsiloxane 6 parts, cetearyl alcohol 7 parts, spermol 6 parts, glyceryl stearate 5 parts, PEG-75 distearate 8 parts, ceteth-205 parts, stereth-205 parts, carbomer 7 parts, allantoin 7 parts, laurocapram 3 parts, tridecyl alcohol salicylate 6 parts, Mentholum 2 parts, quaternary ammonium salt-735 parts, beta glucan 8 parts, triethanolamine 3 parts, polyacrylate-135 parts, Parleam 4 parts, polysorbate-203 parts, Camphora 2 parts, 1,2-hexanediol 10 parts, decoyl hydroximic acid 8 parts, 1,3-propylene glycol 6 parts, hexanediol 5 parts and the mixing of 6 parts of essence, 85 DEG C of heated and stirred are complete to dissolving, and are cooled to 45 DEG C, add the natural herbs extracting solution of purification prepared by the step (2) of 40 parts, stir, be eventually adding the beer yeast extract of 15 parts, the uva cell extract of 10 parts, insulation rotary evaporation is paste, obtains the Whelk-eliminating paste based on high-purity herb extract.

Embodiment 4:

(1) by weight, by Herba Centellae 15 parts, Rhizoma Polygoni Cuspidati 15 parts, Radix Scutellariae 15 parts, Folium Camelliae sinensis 5 parts, Glycyrrhiza glabra L. 10 parts, Flos Chrysanthemi 10 parts, Herba Rosmarini Officinalis 5 parts, Salix alba 10 parts, Fructus Hedychii Spicati 10 parts, Radix Salviae Miltiorrhizae 20 parts, root of Gentiana lutea 10 parts, Folium Eriobotryae 15 parts, licorice 5 parts, Flos Lonicerae 15 parts, Flos Tagetis Erectae 5 parts, the natural herbs that Bellis perennis is 10 parts is cleaned after drying, cutting is pulverized, it is mixed in proportion, first add 95% ethanol water with materials than for 1:8, ultrasonic disperse, through 100 DEG C of circumfluence distillation 2h, then 80% ethanol water is added with materials than for 1:5 again, ultrasonic disperse, through 80 DEG C of circumfluence distillation 1h, filtrate rotary evaporation is concentrated into without alcohol taste, obtain the extracting solution of the natural herbs that extraction ratio is 87%.

(2) the extracting solution centrifuging and taking supernatant of natural herbs prepared by step (1), it is subsequently placed in dry compound recipe-JD resin, stand 20h, sucking filtration 5h, again the macroporous resin after absorption is transferred in the ethanol water of 85%, stand sucking filtration, take out macroporous resin, by filtrate rotary evaporation to without alcohol taste, obtain the natural herbs extracting solution of purification, wherein component is by weight, comprise rheum emodin 40 parts, chrysophanol 25 parts, baicalin 20 parts, salicin 15 parts, TANSHINONES 35 parts, gentiopicrin 11 parts, ursolic acid 17 parts, glycyrrhizic acid 8 parts, chlorogenic acid 8 parts, Flos Chrysanthemi flavone 18 parts, resveratrol 19 parts, rosmarinic acid 8 parts.

(3) by weight, by deionized water 35 parts, butanediol 6 parts, propylene glycol 4 parts, glycine betaine 9 parts, 6 parts of carbamide, 6 parts of polyglutamic acid sodium, isononyl isononanoate 10 parts, polydimethylsiloxane 5 parts, ring five polydimethylsiloxane 5 parts, cetearyl alcohol 6 parts, spermol 6 parts, glyceryl stearate 6 parts, PEG-75 distearate 7 parts, ceteth-207 parts, stereth-206 parts, carbomer 8 parts, allantoin 6 parts, laurocapram 3 parts, tridecyl alcohol salicylate 6 parts, Mentholum 2 parts, quaternary ammonium salt-735 parts, beta glucan 7 parts, triethanolamine 3 parts, polyacrylate-136 parts, Parleam 2 parts, polysorbate-202 parts, Camphora 1 part, 1,2-hexanediol 8 parts, decoyl hydroximic acid 7 parts, 1,3-propylene glycol 5 parts, hexanediol 4-8 part and the mixing of 6 parts of essence, 83 DEG C of heated and stirred, to dissolving completely, are cooled to 47 DEG C, add the natural herbs extracting solution of purification prepared by the step (2) of 35 parts, stir, be eventually adding the beer yeast extract of 12 parts, the uva cell extract of 14 parts, insulation rotary evaporation is paste, obtains the Whelk-eliminating paste based on high-purity herb extract.

Embodiment 5:

(1) by weight, by Herba Centellae 9 parts, Rhizoma Polygoni Cuspidati 15 parts, Radix Scutellariae 14 parts, Folium Camelliae sinensis 5 parts, Glycyrrhiza glabra L. 8 parts, Flos Chrysanthemi 7 parts, Herba Rosmarini Officinalis 6 parts, Salix alba 12 parts, Fructus Hedychii Spicati 11 parts, Radix Salviae Miltiorrhizae 15 parts, root of Gentiana lutea 8 parts, Folium Eriobotryae 13 parts, licorice 6 parts, Flos Lonicerae 15 parts, Flos Tagetis Erectae 8 parts, the natural herbs that Bellis perennis is 7 parts is cleaned after drying, cutting is pulverized, it is mixed in proportion, first add 90% ethanol water with materials than for 1:10, ultrasonic disperse, through 90 DEG C of circumfluence distillation 4h, then 7% ethanol water is added with materials than for 1:6 again, ultrasonic disperse, through 75 DEG C of circumfluence distillation 1.5h, rotary evaporation is concentrated into without alcohol taste, obtain the extracting solution of the natural herbs that extraction ratio is 82.

(2) the extracting solution centrifuging and taking supernatant of natural herbs prepared by step (1), it is subsequently placed in dry compound recipe-JD resin, stand 12h, sucking filtration 4h, again the macroporous resin after absorption is transferred in the ethanol water of 90%, stand sucking filtration, take out macroporous resin, by filtrate rotary evaporation to without alcohol taste, obtain the natural herbs extracting solution of purification, wherein component is by weight, comprise rheum emodin 35 parts, yellow 20 parts of phenol, baicalin 20 parts, salicin 20 parts, TANSHINONES 30 parts, gentiopicrin 11 parts, ursolic acid 17 parts, glycyrrhizic acid 7 parts, chlorogenic acid 8 parts, Flos Chrysanthemi flavone 17 parts, resveratrol 17 parts, rosmarinic acid 7 parts.

(3) by weight, by deionized water 40 parts, butanediol 5 parts, propylene glycol 4 parts, glycine betaine 8 parts, 7 parts of carbamide, 5 parts of polyglutamic acid sodium, isononyl isononanoate 12 parts, polydimethylsiloxane 4 parts, ring five polydimethylsiloxane 7 parts, cetearyl alcohol 4 parts, spermol 7 parts, glyceryl stearate 6 parts, PEG-75 distearate 5 parts, ceteth-206 parts, stereth-204 parts, carbomer 10 parts, allantoin 5 parts, laurocapram 4 parts, tridecyl alcohol salicylate 5 parts, Mentholum 3 parts, quaternary ammonium salt-733 parts, beta glucan 9 parts, triethanolamine 5 parts, polyacrylate-133 parts, Parleam 1 part, polysorbate-202 parts, Camphora 3 parts, 1,2-hexanediol 12 parts, decoyl hydroximic acid 11 parts, 1,3-propylene glycol 3 parts, hexanediol 4 parts and the mixing of 3 parts of essence, 90 DEG C of heated and stirred are complete to dissolving, and are cooled to 45 DEG C, add the natural herbs extracting solution of purification prepared by the step (2) of 50 parts, stir, be eventually adding the beer yeast extract of 16 parts, the uva cell extract of 8 parts, insulation rotary evaporation is paste, obtains the Whelk-eliminating paste based on high-purity herb extract.

Embodiment 6:

(1) by weight, by Herba Centellae 20 parts, Rhizoma Polygoni Cuspidati 25 parts, Radix Scutellariae 3 parts, Folium Camelliae sinensis 2 parts, Glycyrrhiza glabra L. 12 parts, Flos Chrysanthemi 10 parts, Herba Rosmarini Officinalis 3 parts, Salix alba 15 parts, Fructus Hedychii Spicati 6 parts, Radix Salviae Miltiorrhizae 20 parts, root of Gentiana lutea 5 parts, Folium Eriobotryae 18 parts, licorice 9 parts, Flos Lonicerae 19 parts, Flos Tagetis Erectae 3 parts, the natural herbs that Bellis perennis is 5 parts is cleaned after drying, cutting is pulverized, it is mixed in proportion, first add 95% ethanol water with materials than for 1:10, ultrasonic disperse, through 100 DEG C of circumfluence distillation 2h, then 80% ethanol water is added with materials than for 1:6 again, ultrasonic disperse, through 75 DEG C of circumfluence distillation 2h, filtrate rotary evaporation is concentrated into without alcohol taste, obtain the extracting solution of the natural herbs that extraction ratio is 87%.

(2) the extracting solution centrifuging and taking supernatant of natural herbs prepared by step (1), it is subsequently placed in dry HPD-750 resin, stand 24h, sucking filtration 4h, again the macroporous resin after absorption is transferred in the ethanol water of 90%, stand sucking filtration, take out macroporous resin, by filtrate rotary evaporation to without alcohol taste, obtain the natural herbs extracting solution of purification, wherein component is by weight, comprise rheum emodin 50 parts, chrysophanol 30 parts, baicalin 25 parts, salicin 15 parts, TANSHINONES 40 parts, gentiopicrin 15 parts, ursolic acid 15 parts, glycyrrhizic acid 10 parts, chlorogenic acid 10 parts, Flos Chrysanthemi flavone 25 parts, resveratrol 15 parts, rosmarinic acid 10 parts.

(3) by weight, by deionized water 50 parts, butanediol 5 parts, propylene glycol 6 parts, glycine betaine 12 parts, 6 parts of carbamide, 5 parts of polyglutamic acid sodium, isononyl isononanoate 12 parts, polydimethylsiloxane 8 parts, ring five polydimethylsiloxane 5 parts, cetearyl alcohol 4 parts, spermol 5 parts, glyceryl stearate 6 parts, PEG-75 distearate 9 parts, ceteth-206 parts, stereth-204 parts, carbomer 5 parts, allantoin 5 parts, laurocapram 3 parts, tridecyl alcohol salicylate 5 parts, Mentholum 1 part, quaternary ammonium salt-733 parts, beta glucan 5 parts, triethanolamine 2 parts, polyacrylate-133 parts, Parleam 1-5 part, polysorbate-202-4 part, Camphora 1-3 part, 1,2-hexanediol 5-12 part, decoyl hydroximic acid 4 parts, 1,3-propylene glycol 3 parts, hexanediol 4 parts and the mixing of 3 parts of essence, 80 DEG C of heated and stirred are complete to dissolving, and are cooled to 50 DEG C, add the natural herbs extracting solution of purification prepared by the step (2) of 50 parts, stir, be eventually adding the beer yeast extract of 10 parts, the uva cell extract of 8 parts, insulation rotary evaporation is paste, obtains the Whelk-eliminating paste based on high-purity herb extract.

After testing, the safety of the Whelk-eliminating paste based on high-purity herb extract prepared by embodiment 1-6, stability, antibiotic property, and whitening after using 30 days, the result of the treated effect of light speckle and acne, as shown in the table:

Further, select 10-20 year the teenager Whelk-eliminating paste 30 days based on high-purity herb extract that uses embodiment 1-6 to prepare and untapped contrast, the result of the sebum secretion amount change of test and the change of acne lesions quantity is as follows:

As seen from the above table, the Whelk-eliminating paste stable performance based on high-purity herb extract prepared by the present invention, life-time service is effective to acne treatment, but also has effect of whitening, moisturizing, light speckle concurrently.

Above-described embodiment is illustrative principles of the invention and effect thereof only, not for the restriction present invention. Above-described embodiment all under the spirit and category of the present invention, can be modified or change by any those skilled in the art. Therefore, art has usually intellectual such as modifying without departing from all equivalences completed under disclosed spirit and technological thought or change, must be contained by the claim of the present invention.

Claims

1. the Whelk-eliminating paste based on high-purity herb extract, it is characterized in that, the active component of described Whelk-eliminating paste has following natural herb extract by weight ratio to constitute: Herba Centellae 5-20, Rhizoma Polygoni Cuspidati 8-25, Radix Scutellariae 3-16, Folium Camelliae sinensis 2-8, Glycyrrhiza glabra L. 4-12, Flos Chrysanthemi 5-10, Herba Rosmarini Officinalis 3-9, Salix alba 5-15, Fructus Hedychii Spicati 6-14, Radix Salviae Miltiorrhizae 10-20, root of Gentiana lutea 5-10, Folium Eriobotryae 8-18, licorice 5-9, Flos Lonicerae 4-19, Flos Tagetis Erectae 3-11, Bellis perennis 5-13.

2. a kind of Whelk-eliminating paste based on high-purity herb extract according to claim 1, it is characterised in that the extraction ratio of described natural herb extract is higher than 80%, the purity of described natural herb extract is higher than 87%.

3. a kind of Whelk-eliminating paste based on high-purity herb extract according to claim 1, it is characterised in that possibly together with beer yeast extract, uva cell extract and auxiliary agent in described Whelk-eliminating paste.

4. a kind of Whelk-eliminating paste based on high-purity herb extract according to claim 3, it is characterized in that, in described Whelk-eliminating paste, auxiliary agent includes: deionized water, butanediol, propylene glycol, glycine betaine, carbamide, polyglutamic acid sodium, isononyl isononanoate, polydimethylsiloxane, ring five polydimethylsiloxane, cetearyl alcohol, spermol, glyceryl stearate, PEG-75 distearate, ceteth-20, stereth-20, carbomer, allantoin, laurocapram, tridecyl alcohol salicylate, Mentholum, quaternary ammonium salt-73, beta glucan, triethanolamine, polyacrylate-13, Parleam, polysorbate-20, Camphora, 1, 2-hexanediol, decoyl hydroximic acid, 1, ammediol, hexanediol and essence.

5. the preparation method based on the Whelk-eliminating paste of high-purity herb extract, it is characterised in that: comprise the following steps:

6. the preparation method of a kind of Whelk-eliminating paste based on high-purity herb extract according to claim 5, it is characterized in that: in described step (1), the first time of circumfluence distillation: the concentration of ethanol water is 80-95%, materials are than for 1:8-10, and temperature is 80-100 DEG C, and extraction time is 2-4h, the second time of circumfluence distillation: the concentration of ethanol water is 60-80%, materials are than for 1:5-6, and temperature is 75-80 DEG C, and extraction time is 1-2h.

7. the preparation method of a kind of Whelk-eliminating paste based on high-purity herb extract according to claim 5, it is characterised in that: in described step (1), in the extracting solution of natural herbs, the extraction ratio of effective ingredient is 80-90%.

8. the preparation method of a kind of Whelk-eliminating paste based on high-purity herb extract according to claim 5, it is characterised in that: in described step (2), dry macroporous resin is compound recipe-JD resin and HPD-750 resin.

9. the preparation method of a kind of Whelk-eliminating paste based on high-purity herb extract according to claim 5, it is characterised in that: in described step (2), the time of standing is 12-24h, sucking filtration 4-6h.

10. the preparation method of a kind of Whelk-eliminating paste based on high-purity herb extract according to claim 5, it is characterized in that: in described step (2), composition in the natural herbs extracting solution of purification, by weight, rheum emodin 25-50 part, chrysophanol 15-35 part, baicalin 20-30 part, salicin 15-25 part, TANSHINONES 20-40 part, gentiopicrin 10-15 part, ursolic acid 15-20 part, glycyrrhizic acid 5-10 part, chlorogenic acid 5-10 part, Flos Chrysanthemi flavone 15-25 part, resveratrol 15-20 part, rosmarinic acid 5-10 part are comprised.