CN106473944A - A kind of acne-removing composition containing antibacterial peptide and acne eliminating cream - Google Patents
A kind of acne-removing composition containing antibacterial peptide and acne eliminating cream Download PDFInfo
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- CN106473944A CN106473944A CN201611160776.5A CN201611160776A CN106473944A CN 106473944 A CN106473944 A CN 106473944A CN 201611160776 A CN201611160776 A CN 201611160776A CN 106473944 A CN106473944 A CN 106473944A
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- antibacterial peptide
- removing composition
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Abstract
The present invention provides a kind of acne-removing composition containing antibacterial peptide, including following component and its mass fraction：5～20 parts of Herba Centellae extract, 1～10 part of liquirtin and 0.5～3 part of antibacterial peptide.The invention belongs to cosmetic technical field, the acne-removing composition that the present invention provides passes through to compound antibacterial peptide in certain proportion with Herba Centellae extract and liquirtin, Synergistic can be realized, more than 90% is all reached to the bacteriostasis rate of comedo relevant bacteria species, there is significant prevention effect to comedo, safety is good, reduces the concentration of antibacterial peptide.
Description
Technical field
The invention belongs to cosmetic technical field, more particularly, to a kind of acne-removing composition containing antibacterial peptide and acne eliminating cream.
Background technology
Comedo is a kind of pilosebaceous chronic inflammatory skin, is dermatology common disease, is mainly in face, neck
The position that the sebaceous gland such as portion, shirtfront back are enriched, is common in the youth of both sexes of adolescence, the traditional Chinese medical science claims " acne ", and doctor trained in Western medicine claims
For " acne ".During adolescence, internal hormone can stimulate hair growth, promotes smegma more many greases of sauce, hair and skin
Adipose gland therefore piles up many materials, makes oils and fatss and antibacterial attachment, causes the reaction such as red swelling of the skin.According to statistics, more than 80% green grass or young crops
Year, different degrees of comedo in adolescence in men and women, caused great puzzlement to youth of both sexes.
Modern medicine is thought：Comedo is the result of multifactor functioning, and the growth of comedo typically requires satisfaction such as
Lower condition：1. hair follicle keratinization is hyperfunction, clogging of pores；2. endotheliosiss, sebum secretion is vigorous；3. the growing of antibacterial.It is present in
Bacterial species in pilosebaceous unit are a lot, including bacillus pyocyaneus, Candida albicans and propionibacterium acness etc., wherein acne third
Acidfast bacilli is the main antibacterial causing comedo, belongs to typical gram-positive anaerobic bacterium.Propionibacterium acness metabolism produces
Fatty acid can stimulate skin and promote sebaceous gland excessive secretion so that sebum drainage difficulty, ultimately result in inflammatory papules,
Acne and the generation of pustule, and then cause hair follicle inflammation, skin injury and form cicatrix.
Acne-eliminating cosmetic species in the market is various, have prevent and treat acne effect cosmetics have cream, frost, emulsion etc.
Dosage form, conventional active component has salicylic acid, phenol, Camphora, VitAVitE, chlorophyll, estrogen, retinol palm fibre
Glycerin monostearate, carbamide capsule, plant extract, antibiotic etc..The raising requiring with security performance, antibiotic and hormonal substance exist
Disabled or limit the use of in acne-eliminating cosmetic.
Chinese patent application CN 105012479 discloses a kind of acne-removing composition and Whelk-eliminating paste, and acne-removing composition includes cattle
Oily fruit tree fruit fat, Cortex Phellodendri extract, black extract of willow bark, Herba portulacae extract, Folium perillae extract, Herba Centellae extract and green
Bean extract, achieves preferable anti-acne effect by the collective effect of multiple extracts, but the component of active component is more complicated.
Chinese patent application CN 105411873 disclose antibacterial peptide as antiinflammatory acne removing agent cosmetics preparation in should
With, using antibacterial peptide as single-activity composition, the concentration of antibacterial peptide liquid be can effectively suppress when 3.0% propionibacterium acness and
The growth of staphylococcus aureus, higher to the concentration requirement of antibacterial peptide.
Therefore it provides a kind of anti-acne active component is simpler, antibacterial peptide concentration is relatively low, realizes the anti-acne combination of Synergistic
Thing and its cosmetics are significant.
Content of the invention
For solving problems of the prior art, inventor provides a kind of acne-removing composition containing antibacterial peptide, by inciting somebody to action
Antibacterial peptide is compounded in certain proportion with Herba Centellae extract and liquirtin, it is possible to achieve Synergistic, to comedo correlation bacterium
The bacteriostasis rate planted all reaches more than 90%, has significant prevention effect to comedo, safety is good, reduces making of antibacterial peptide
Use concentration.Based on above-mentioned discovery, thus completing the present invention.
The purpose of the present invention will be further described in detail below reflect and description.
The present invention provides a kind of acne-removing composition containing antibacterial peptide, including following component and its mass fraction：Herba Centellae carries
Take 5～20 parts of thing, 1～10 part of liquirtin and 0.5～3 part of antibacterial peptide.
In above-mentioned composition, antibacterial peptide is a kind of biological Small-molecule basic with biological activity producing through induction in vivo
Polypeptide, is made up of 20～60 amino acid residues, and molecular weight 2000～7000 about, has broad spectrum antibiotic activity, to multiple
Antibacterial has stronger killing action；Herba Centellae extract has functions that antiinflammatory, dispels aging cutin, can effectively dissolve pore
The grease soils of depths, dredge blockage hair follicle, beneficial to the discharge of toxin, improves skin quality；Liquirtin energy conditioning skin, antiallergic,
Activating cell, plays the effect strengthening other active components effect.Using technique scheme, by Herba Centellae extract, sweet
Careless glycosides and the Synergistic of antibacterial peptide, from sterilization, antiinflammatory, oils and fatss control, aging cutin is dispelled, it is comprehensive to realize in terms of skin condition etc.
Close preventing and treating, more than 90% is all reached to the bacteriostasis rate of comedo relevant bacteria species, there is to comedo significant prevention effect, safety
Property is good, reduces the concentration of antibacterial peptide.
Preferably, the described acne-removing composition containing antibacterial peptide, including following component and its mass fraction：Herba Centellae is extracted
10～15 parts of thing, 3～8 parts of liquirtin and 1～3 part of antibacterial peptide.
It is highly preferred that the described acne-removing composition containing antibacterial peptide, including following component and its mass fraction：Herba Centellae carries
Take 12 parts of thing, 6 parts of liquirtin and 2 parts of antibacterial peptide.
Preferably, described antibacterial peptide is selected from house fly antibiotic peptide or antibacterial peptide DC.Antibacterial peptide DC can refer to patent
200510032743.8 in method prepare, the activity of antibacterial peptide DC is 5000IU/mL.
Additionally, the present invention also provides a kind of acne eliminating cream, including following component and its parts by weight：Described acne-removing composition
6～12 parts, 2～4 parts of squalane, 1～3 part of Semen Tritici aestivi germ oil, 1～3 part of cetearyl glucoside, isopropyl myristate 1
～3 parts, 1～3 part of ethylhexyl palmitate, 1～2 part of octyl methoxycinnamate, 3～5 parts of glycerol, 0.5～2 part of xanthan gum,
0.5～2 part of cetearyl alcohol, 2～6 parts of Sorbitol, 2～6 parts of propylene glycol and 60～80 parts of water.
Preferably, described acne eliminating cream, including following component and its parts by weight：10 parts of described acne-removing composition, angle
3 parts of shark alkane, 2 parts of Semen Tritici aestivi germ oil, 2 parts of cetearyl glucoside, 2 parts of isopropyl myristate, ethylhexyl palmitate 1
Part, 1 part of octyl methoxycinnamate, 4 parts of glycerol, 1 part of xanthan gum, 2 parts of cetearyl alcohol, 3 parts of Sorbitol, 3 parts of propylene glycol and
66 parts of water.
Preferably, described acne eliminating cream, also includes 0.1～1 part of essence and/or 0.1～1 part of chelating agen.
Correspondingly, the present invention also provides the preparation method of acne eliminating cream, comprises the steps：
S1 weigh squalane, Semen Tritici aestivi germ oil, cetearyl glucoside, isopropyl myristate, palm acid ethyl oneself
Ester, octyl methoxycinnamate and cetearyl alcohol, in first reactor, are stirred and heated to 80～85 DEG C, obtain material A,
Insulation is standby；
S2 weighs glycerol, Sorbitol, propylene glycol, xanthan gum and water in second reactor, is stirred and heated to 80～85
DEG C, it is slowly added to described material flow A, stir homogenizing, obtain material B；Preferably homogenizing 5～10min.
Described material B is cooled to 40～45 DEG C by S3, weighs and adds described acne-removing composition, stir, cooling,
Obtain acne eliminating cream.
Compared with prior art, the invention has the beneficial effects as follows：The acne-removing composition containing antibacterial peptide that the present invention provides leads to
Cross the Synergistic of Herba Centellae extract, liquirtin and antibacterial peptide, from sterilization, antiinflammatory, oils and fatss control, aging cutin is dispelled, skin
The aspects such as skin conditioning realize integrated control, all reach more than 90% to the bacteriostasis rate of comedo relevant bacteria species, comedo is had
Significantly prevention effect, safety is good, reduces the concentration of antibacterial peptide.The Whelk-eliminating paste that the present invention provides can significantly reduce skin
Skin fat content, promotes the quick absorption of active component, prevents the symptoms such as the blocking of pore, safety is good, steady quality, room
Temperature still has significant fungistatic effect to comedo relevant bacteria species after preserving 2 years.
Specific embodiment
Below by specific embodiment, the present invention is described in further detail.
In the present invention, involved component and raw material are conventional commercial product, or can pass through the ordinary skill in the art
Means obtain, for example：Herba Centellae extract is purchased from Guilin Laiyin Biotechnology Co., Ltd., and No. CAS is 84696-21-9.
Embodiment one contains the acne-removing composition of antibacterial peptide
Acne-removing composition containing antibacterial peptide includes following component and its mass fraction：12 parts of Herba Centellae extract, liquirtin 6
Part and 2 parts of antibacterial peptide DC.
Preparation method：Weigh Herba Centellae extract, liquirtin and antibacterial peptide DC, mix, obtain the anti-acne group containing antibacterial peptide
Compound.
Embodiment two contains the acne-removing composition of antibacterial peptide
Acne-removing composition containing antibacterial peptide includes following component and its mass fraction：15 parts of Herba Centellae extract, liquirtin 8
Part and 3 parts of house fly antibiotic peptide.
Preparation method is with embodiment one.
Embodiment three contains the acne-removing composition of antibacterial peptide
Acne-removing composition containing antibacterial peptide includes following component and its mass fraction：10 parts of Herba Centellae extract, liquirtin 3
Part and 1 part of antibacterial peptide DC.
Preparation method is with embodiment one.
Comparative example 1
Acne-removing composition includes following component and its mass fraction：18 parts of Herba Centellae extract and 2 parts of antibacterial peptide DC.
Preparation method is with embodiment one.
Comparative example 1 is with the difference of embodiment one：Without liquirtin, the number of Herba Centellae extract increases.
Comparative example 2
Acne-removing composition includes following component and its mass fraction：18 parts of liquirtin and 2 parts of antibacterial peptide DC.
Preparation method is with embodiment one.
Comparative example 2 is with the difference of embodiment one：Without Herba Centellae extract, the number of liquirtin increases.
Comparative example 3
Acne-removing composition includes following component and its mass fraction：12 parts of Herba Centellae extract, 8 parts of liquirtin.
Preparation method is with embodiment one.
Comparative example 3 is with the difference of embodiment one：Without antibacterial peptide DC, the number of liquirtin increases.
Example IV Whelk-eliminating paste
Acne eliminating cream includes following component and its parts by weight：10 parts of the acne-removing composition of embodiment 1 is 3 parts of squalane, little
2 parts of wheat germ oil, 2 parts of cetearyl glucoside, 2 parts of isopropyl myristate, 1 part of ethylhexyl palmitate, methoxyl group meat
1 part of cinnamate, 4 parts of glycerol, 1 part of xanthan gum, 2 parts of cetearyl alcohol, 3 parts of Sorbitol, 3 parts of propylene glycol and 66 parts of water.
The preparation method of acne eliminating cream comprises the steps：
S1 weigh squalane, Semen Tritici aestivi germ oil, cetearyl glucoside, isopropyl myristate, palm acid ethyl oneself
Ester, octyl methoxycinnamate and cetearyl alcohol, in first reactor, are stirred and heated to 82 DEG C, obtain material A, insulation
Standby；
S2 weighs glycerol, Sorbitol, propylene glycol, xanthan gum and water in second reactor, is stirred and heated to 82 DEG C, delays
Slowly add described material flow A, stir homogenizing 5min, obtain material B；
Described material B is cooled to 42 DEG C by S3, weighs and adds the acne-removing composition of embodiment one, stir, cooling,
Obtain acne eliminating cream.
Comparative example 4
Acne eliminating cream includes following component and its parts by weight：10 parts of the acne-removing composition of comparative example 1,3 parts of squalane, Semen Tritici aestivi
2 parts of germ oil, 2 parts of cetearyl glucoside, 2 parts of isopropyl myristate, 1 part of ethylhexyl palmitate, methoxycinnamate
1 part of misery ester, 4 parts of glycerol, 1 part of xanthan gum, 2 parts of cetearyl alcohol, 3 parts of Sorbitol, 3 parts of propylene glycol and 66 parts of water.
The same example IV of preparation method of acne eliminating cream.
Comparative example 5
Acne eliminating cream includes following component and its parts by weight：10 parts of the acne-removing composition of comparative example 2,3 parts of squalane, Semen Tritici aestivi
2 parts of germ oil, 2 parts of cetearyl glucoside, 2 parts of isopropyl myristate, 1 part of ethylhexyl palmitate, methoxycinnamate
1 part of misery ester, 4 parts of glycerol, 1 part of xanthan gum, 2 parts of cetearyl alcohol, 3 parts of Sorbitol, 3 parts of propylene glycol and 66 parts of water.
The same example IV of preparation method of acne eliminating cream.
Comparative example 6
Acne eliminating cream includes following component and its parts by weight：10 parts of the acne-removing composition of comparative example 3,3 parts of squalane, Semen Tritici aestivi
2 parts of germ oil, 2 parts of cetearyl glucoside, 2 parts of isopropyl myristate, 1 part of ethylhexyl palmitate, methoxycinnamate
1 part of misery ester, 4 parts of glycerol, 1 part of xanthan gum, 2 parts of cetearyl alcohol, 3 parts of Sorbitol, 3 parts of propylene glycol and 66 parts of water.
The same example IV of preparation method of acne eliminating cream.
Test example one safety testing
2015 editions issuing with reference to Ministry of Public Health《Cosmetics health specification》In " human skin patch " related request
With assay method, the embodiment of the present invention four, comparative example 4 are tested to the acne eliminating cream of comparative example 6, respectively 0h, 6h, 12h,
24h, 48h observe dermoreaction, and the experimental result of all trial volunteers is negative findings, skin adverse reaction.
The acne eliminating cream nonirritant that the present invention provides, safety is good.
Test example two bacteriostatic test
With reference to GB 15979-2002《Disposable Sanitary Accessory sanitary standard》" stripping property resists (suppression) bacterium to middle appendix C 4
Product bacteriostasis property test method " carries out the embodiment of the present invention four, the bacteriostasis property of the acne eliminating cream to comparative example 6 for the comparative example 4 is surveyed
Fixed：1. the preparation of bacteria suspension：Test organismss 24h (antibacterial) culture is washed down with 0.03mol/L phosphate buffer, makes
106efu/mL bacteria suspension；2. take respectively by test agent 1g, plus the mixing of people's above-mentioned bacteria suspension 0.1mL even spread, start timing
After 20min, add 9mL 0.03mol/L phosphate buffer fully to mix, after making suitably to dilute, take wherein 3 dilution factors, point
1mL is not taken to be placed in two parallel plates. add corresponding culture medium Hybrid NC machine tool respectively, make colony counting.Above test weight
Multiple 3 times, take its average, set blank simultaneously.Computing formula：X (%)=(A B)/A × 100, wherein X are bacteriostasis rate, A
Averagely reclaim clump count for control sample；B averagely reclaims clump count for test specimen.
Acne-removing evaluation criterion as shown in table 1, evaluate as shown in table 2 by the bacteriostasis efficacy of different acne eliminating creams.
Table 1 acne-removing evaluation criterion
The bacteriostasis efficacy evaluation table of table 2 acne eliminating cream
As known from Table 2, the acne eliminating cream of the embodiment of the present invention four all has very strong bactericidal to comedo relevant bacteria species
Effect, acne-removing is evaluated as effective；And 4 groups of comparative example and 5 groups of comparative example are in the feelings lacking liquirtin or Herba Centellae extract
Under condition, acne-removing is evaluated as effectively, and in the case of lacking antibacterial peptide, bactericidal and bacteriostatic effect significantly reduces 6 groups of comparative example, dispels
Pox efficacy assessments are invalid.It can be seen that, the bactericidal that Herba Centellae extract, liquirtin and antibacterial peptide serve Synergistic is made
With.
Test example three stability test
Accelerated stability test is carried out to the acne eliminating cream of the embodiment of the present invention four, comparative example 4 to comparative example 6, including：Heat-resisting
Test, places 1 month in 45 DEG C of calorstat, observe sample whether be layered, variable color, rotten；Low temperature resistant test, at -10 DEG C
Place 1 month in calorstat, observe sample whether be layered, variable color, rotten.Result is as shown in table 3.
The accelerated stability test result of the different acne eliminating cream of table 3
| Group | Heat resistant test | Low temperature resistant test |
| Example IV group | It is not layered, non-variable color, do not go bad | It is not layered, non-variable color, do not go bad |
| 4 groups of comparative example | Layering, non-variable color, rotten | It is not layered, non-variable color, do not go bad |
| 5 groups of comparative example | It is not layered, non-variable color, do not go bad | It is not layered, non-variable color, do not go bad |
| 6 groups of comparative example | It is not layered, non-variable color, do not go bad | It is not layered, non-variable color, do not go bad |
As known from Table 3, the good stability of the acne eliminating cream that the present invention provides, and 4 groups of comparative example is in the situation without liquirtin
Under, through heat resistant test, layering and denaturalization phenomenon occur, illustrate that liquirtin plays an important role to the stability of system of the present invention.
Additionally, example IV group through room temperature preserve 2 years after, not yet layering, non-variable color, do not go bad, bacteriostasis efficacy is carried out
Detection, result is as shown in table 4.As known from Table 4, after the acne eliminating cream of example IV preserves 2 years, remain to that there is very strong bactericidal
Effect, good stability, acne-removing is evaluated as effective.
The acne eliminating cream of table 4 example IV preserve 1 year and 2 years after bacteriostasis efficacy evaluation table
The clinical trial of test example four acne eliminating cream
The acne eliminating cream of the acne eliminating cream of example IV and certain famous brand name commercially available is carried out the on probation of comedo patient volunteer,
Take the affected part being coated in cleaning in right amount, daily 2 times, try out 4 weeks.In comedo patient volunteer, female 64 people, male 56 people, the age
Between 20～30 years old, face has obvious acne and small pox, and skin characteristic is oily skin, and no dermatosiss allergies meet
Experimenter volunteers inclusion criteria, is randomly divided into 2 groups, every group of 60 people (female 32 people, male 28 people), and the difference between 2 groups does not have system
Meaning learned by meter.Skin oil and fat content Sebumeter test using German Courage Khazaka company (German CK company) is visited
Head is detected, patient volunteer in the 0th day, the 14th day, the content of the skin oil and fat of the 28th day, result as shown in table 5, simultaneously
Collect patient volunteer after using 28 days anti-acne, acne print desalinate and the aspect such as pore shrinks evaluation marking, each expire
It is divided into 10 points, result is as shown in table 6.
Table 5 patient volunteer tries out the content of the skin oil and fat of different time
Table 6 patient volunteer tries out the evaluation marking of acne eliminating cream of the present invention
As known from Table 5, the acne eliminating cream that the present invention provides can significantly reduce fat content, using the oils and fatss after 28 days after using
Content reduces up to 59.4%, better than the 53.7% of commercially available matched group.
As known from Table 6, the acne eliminating cream that the present invention provides all obtains on probation at aspects such as anti-acne, acne print desalination and pore contractions
The accreditation of person, except releiving in antiinflammatory, aspect is suitable with commercially available matched group, and in anti-acne, acne print is desalinated, pore shrinks and skin oil
Light minimizing aspect is all substantially better than commercially available matched group.The diseases such as skin pruritus, twinge in all non-someone of whole patient volunteers
Shape, illustrates that the acne eliminating cream that the present invention provides has good anti-acne effect, and safety is good.
Above content is to further describe it is impossible to assert with reference to specific preferred implementation is made for the present invention
Being embodied as of the present invention is confined to these explanations.For general technical staff of the technical field of the invention,
On the premise of present inventive concept, some simple deduction or replace can also be made, all should be considered as belonging to the present invention's
Protection domain.
Claims (8)
1. a kind of acne-removing composition containing antibacterial peptide it is characterised in that：Including following component and its mass fraction：Herba Centellae is extracted
5～20 parts of thing, 1～10 part of liquirtin and 0.5～3 part of antibacterial peptide.
2. the acne-removing composition containing antibacterial peptide according to claim 1 it is characterised in that：Including following component and its quality
Number：10～15 parts of Herba Centellae extract, 3～8 parts of liquirtin and 1～3 part of antibacterial peptide.
3. the acne-removing composition containing antibacterial peptide according to claim 2 it is characterised in that：Including following component and its quality
Number：12 parts of Herba Centellae extract, 6 parts of liquirtin and 2 parts of antibacterial peptide.
4. the acne-removing composition containing antibacterial peptide according to any one of claim 1 to 3 it is characterised in that：Described antibacterial
Peptide is selected from house fly antibiotic peptide or antibacterial peptide DC.
5. a kind of acne eliminating cream it is characterised in that：Including following component and its parts by weight：Any one of Claims 1-4
6～12 parts of acne-removing composition, 2～4 parts of squalane, 1～3 part of Semen Tritici aestivi germ oil, 1～3 part of cetearyl glucoside, lima bean
1～3 part of cool isopropyl propionate, 1～3 part of ethylhexyl palmitate, 1～2 part of octyl methoxycinnamate, 3～5 parts of glycerol, xanthan
0.5～2 part of glue, 0.5～2 part of cetearyl alcohol, 2～6 parts of Sorbitol, 2～6 parts of propylene glycol and 60～80 parts of water.
6. acne eliminating cream according to claim 5 it is characterised in that：Including following component and its parts by weight：Claim 1
10 parts of acne-removing composition any one of to 4,3 parts of squalane, 2 parts of Semen Tritici aestivi germ oil, 2 parts of cetearyl glucoside,
2 parts of isopropyl myristate, 1 part of ethylhexyl palmitate, 1 part of octyl methoxycinnamate, 4 parts of glycerol, 1 part of xanthan gum, whale
2 parts of wax stearyl alcohol, 3 parts of Sorbitol, 3 parts of propylene glycol and 66 parts of water.
7. the acne eliminating cream according to claim 5 or 6 it is characterised in that：Also include 0.1～1 part of essence and/or chelating agen
0.1～1 part.
8. acne eliminating cream according to claim 5 preparation method it is characterised in that：Comprise the steps：
S1 weighs squalane, Semen Tritici aestivi germ oil, cetearyl glucoside, isopropyl myristate, ethylhexyl palmitate, first
Epoxide cinnamic acid monooctyl ester and cetearyl alcohol, in first reactor, are stirred and heated to 80～85 DEG C, obtain material A, insulation
Standby；
S2 weighs glycerol, Sorbitol, propylene glycol, xanthan gum and water in second reactor, is stirred and heated to 80～85 DEG C, delays
Slowly add described material flow A, stir homogenizing, obtain material B；
Described material B is cooled to 40～45 DEG C by S3, weighs and adds described acne-removing composition, stir, and cooling obtains
Acne eliminating cream.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108324586A (en) * | 2018-04-08 | 2018-07-27 | 北京皓尔生物科技有限公司 | A kind of antibacterial anti-inflammatory composition and its application |
| CN108403582A (en) * | 2018-04-08 | 2018-08-17 | 北京皓尔生物科技有限公司 | A kind of anti-acne, acne-removing composition and its application containing antibacterial peptide |
| CN110279844A (en) * | 2019-01-31 | 2019-09-27 | 浙江星杭泰乐生物医药有限公司 | Artificial synthetic antimicrobial peptide is preparing application and inhibiting bacteria and diminishing inflammation acne-removing composition in inhibiting bacteria and diminishing inflammation acne-eliminating cosmetic or external medicine preparation |
| CN110507680A (en) * | 2019-09-04 | 2019-11-29 | 广州市半月美医药科技有限公司 | A kind of compound external-use liniment and preparation method thereof for treating face acnes, acne rosacea |
| CN115487114A (en) * | 2022-10-12 | 2022-12-20 | 广东粤港澳大湾区黄埔材料研究院 | Antibacterial peptide composition, acne-removing cream containing antibacterial peptide composition and preparation method of acne-removing cream |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108324586A (en) * | 2018-04-08 | 2018-07-27 | 北京皓尔生物科技有限公司 | A kind of antibacterial anti-inflammatory composition and its application |
| CN108403582A (en) * | 2018-04-08 | 2018-08-17 | 北京皓尔生物科技有限公司 | A kind of anti-acne, acne-removing composition and its application containing antibacterial peptide |
| CN110279844A (en) * | 2019-01-31 | 2019-09-27 | 浙江星杭泰乐生物医药有限公司 | Artificial synthetic antimicrobial peptide is preparing application and inhibiting bacteria and diminishing inflammation acne-removing composition in inhibiting bacteria and diminishing inflammation acne-eliminating cosmetic or external medicine preparation |
| CN110507680A (en) * | 2019-09-04 | 2019-11-29 | 广州市半月美医药科技有限公司 | A kind of compound external-use liniment and preparation method thereof for treating face acnes, acne rosacea |
| CN110507680B (en) * | 2019-09-04 | 2022-08-19 | 广州市半月美医药科技有限公司 | Compound external liniment for treating facial acne and acne rosacea and preparation method thereof |
| CN115487114A (en) * | 2022-10-12 | 2022-12-20 | 广东粤港澳大湾区黄埔材料研究院 | Antibacterial peptide composition, acne-removing cream containing antibacterial peptide composition and preparation method of acne-removing cream |
| CN115487114B (en) * | 2022-10-12 | 2023-10-03 | 广东粤港澳大湾区黄埔材料研究院 | Antibacterial peptide composition, acne-removing cream containing antibacterial peptide composition and preparation method of acne-removing cream |
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| CN106473944B (en) | 2019-07-02 |
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