CN109199962A - A kind of acne-removing composition and cosmetics - Google Patents
A kind of acne-removing composition and cosmetics Download PDFInfo
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- CN109199962A CN109199962A CN201811336789.2A CN201811336789A CN109199962A CN 109199962 A CN109199962 A CN 109199962A CN 201811336789 A CN201811336789 A CN 201811336789A CN 109199962 A CN109199962 A CN 109199962A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Abstract
The invention discloses a kind of acne-removing compositions, include purslane extract, kawakaw extract, Gotu Kola P.E, polygonum cuspidate root extract, radix scutellariae root extract, green-tea extract, glycyrrhiza glabra root extract, german chamomile flower extract and Rosmarinus officinalis extract.Acne-removing composition of the present invention includes 9 kinds of natural plant extracts, its effect can be given full play to, with preferable antibacterial, antiphlogistic effects, inflammation skin can be repaired, cutaneous immunisation power is adjusted, skin barrier is repaired, has certain repair for impaired skin, prevent small pox back and forth to break out, and the acne-removing composition is mildly non-stimulated.The present invention also provides a kind of cosmetics comprising the acne-removing composition.
Description
Technical field
The present invention relates to a kind of cosmetics, and in particular to a kind of acne-removing composition and cosmetics.
Background technique
Cosmetics are the necessitys of people's daily life.It has nursing skin, improvement skin quality and the makings for promoting people
Irreplaceable role.With the development of science and technology with the progress in epoch, people are also higher and higher to its expectation.Past
20 years, Chinese Cosmetic Manufacture and consumption follow international trend closely, every year with higher than 15% speed develop.Wherein function
Property, curative effect-type product development it is more rapid.
Acne is a kind of chronic inflammation of pilosebaceous follicle, is common in the youth of both sexes of adolescence and pressure of staying up late
Big youth of both sexes occur mainly in face, shirtfront and omoplate position, form papule, and Chinese medicine claims " acne ", and doctor trained in Western medicine name of disease is
" acne ".Its form of expression is mainly acne, papule, warts, tumour and tubercle, and what is had forms scar, seriously affects people
Appearance and image, the employment, social activity and marriage and childbirth etc. of normal person are had an important influence on.
The pathogenic factors of acne be it is various, endocrine is one of factor.In the process that acne are inflamed
In, bacterium plays a very important role.In skin surface and sebaceous glands hair follicle, it is understood that there may be some microorganisms, it is common
Have Propiobacterium, staphylococcus epidermis and pityrosporum furfur, with the maximum that is related of Propiobacterium and acne inflammation.
Currently, the method for the treatment of acne has very much, predominantly oral drugs and external drug.Oral mode mainly utilizes
Body circulation carrys out Formulations for systemic administration, and to reach the effect for the treatment of acne, the general course for the treatment of is longer, ineffective.External application mode multi-pass crosses trouble
Portion smear to treat, drug can be directly acted on human body face by cosmetic applying so that drug sufficiently with facial contact and
Skin is quickly penetrated into, the time of contact of drug and skin is effectively extended, improves skin absorption of drugs degree, substantially shortens and controls
Treat the period.
But it is treated on Vehicles Collected from Market in the cosmetics of acne mostly containing irritations chemical components such as tartaric acid.It easily causes
The adverse reactions such as skin allergy, injured cutaneous tissue structure, therapeutic effect are unsatisfactory；Although also some Chinese herbal medicine cosmetic nothings
Malicious gubernaculum swashs, but often curative effect is single, and therapeutic effect is bad.Therefore, the cosmetics for studying Novel acne treatment, for patients with acne
Have great importance.
Summary of the invention
A kind of acne-removing composition and makeup are provided it is an object of the invention to overcome in place of the shortcomings of the prior art
Product.
To achieve the above object, the technical scheme adopted by the invention is as follows: a kind of acne-removing composition, comprising purslane extract
Object, kawakaw extract, Gotu Kola P.E, polygonum cuspidate root extract, radix scutellariae root extract, green-tea extract, glycyrrhiza glabra
Root extract, german chamomile flower extract and Rosmarinus officinalis extract.
Purslane extract: anti-inflammatory, anti-irritant, anti-light toxicity.
Gotu Kola P.E: contain in Gotu Kola P.E there are many triterpenes, to treatment jaundice with damp-heat pathogen, heatstroke diarrhea, sand
Blood strangury, too fat to move sore are drenched, injury from falling down has fabulous effect.Centella can link part with corium with compact epidermis, can make
Skin limbers up, and help promotes collagen in skin corium to be formed, and has the effect for enabling skin compact.Impaired tissue can be helped to be cured
Conjunction and consolidation skin.
Polygonum cuspidate root extract: polygonum cuspidate is one of plant of polygonaceae, primary to be longer than East Asia and be distributed widely in China.Polygonum cuspidate
It is used to treat a variety of slight illness in China and japanese traditional medicine, including mycotic infection, a variety of scytitis are cardiovascular
Disease and liver diseases etc..Resveratrol and rheum emodin are the main functional components in polygonum cuspidate.Other ingredients include red anthrone, greatly
Flavine methyl ether and Rhein all have anti-inflammatory, arthritis of dispelling and antimicrobial acivity.
Radix scutellariae root extract: the root of radix scutellariae is used as medicine, bitter, cold in nature, there is heat-clearing and damp-drying drug, purging fire for removing toxin and other effects.Scutellariae,radix
Extract has preferable antibacterial action, has stronger inhibiting effect to Escherichia coli, Pseudomonas aeruginosa, staphylococcus etc..
Green-tea extract: containing a variety of active ingredients in green tea, mainly includes tea polyphenols (catechin), caffeine, fragrance
Oil, minerals, amino acid, vitamin etc..Tea polyphenols have anti-oxidant and bactericidal effect.Clostridium botulinum and spore can be killed, is pressed down
The activity of bacterial exotoxin processed.To causing pyogenic infection, burn, the staphylococcus aureus of wound, modification bacillus to have obviously
Inhibiting effect.
Glycyrrhiza glabra root extract: have effects that very strong antioxidant activity, lighten the stain.The substance is added, so that
Composition has the effect of preferably desalinating acne print.
German chamomile flower extract: there is antiinflammation.
Rosemary leaf extract: having stronger astriction, improves greasy unclean skin, promotes blood circulation.
The combination of above-mentioned 9 kinds of natural plant extracts can give full play to its effect, have preferable antibacterial, antiphlogistic effects,
Inflammation skin can be repaired, cutaneous immunisation power is adjusted, repairs skin barrier.
As the preferred embodiment of acne-removing composition of the present invention, the acne-removing composition includes following parts by weight
Component: 0.5~8 part of purslane extract, 0.5~5 part of kawakaw extract, 0.1~2 part of Gotu Kola P.E, polygoni cuspidati,radix
0.1~2 part of extract, 0.1~2 part of radix scutellariae root extract, 0.1~2 part of green-tea extract, glycyrrhiza glabra root extract 0.1~2
Part, 0.1~2 part of german chamomile flower extract and 0.1~2 part of Rosmarinus officinalis extract.Above-mentioned 9 kinds of natural plant extracts use above-mentioned ratio
When example compounding, fungistatic effect is preferable, and has the effect of certain anti-acne print.
As the more preferable embodiment of acne-removing composition of the present invention, the acne-removing composition includes following parts by weight
Component: 3~8 parts of purslane extract, 0.5~2 part of kawakaw extract, 0.2~1 part of Gotu Kola P.E, polygoni cuspidati,radix
0.2~1 part of extract, 0.2~1 part of radix scutellariae root extract, 0.2~1 part of green-tea extract, glycyrrhiza glabra root extract 0.2~1
Part, 0.2~1 part of german chamomile flower extract and 0.2~1 part of Rosmarinus officinalis extract.Above-mentioned 9 kinds of natural plant extracts use above-mentioned ratio
When example compounding, anti-acne effect more preferably, and can preferably repair impaired skin, and anti-acne prints better effect.
As the most preferred embodiment of acne-removing composition of the present invention, the acne-removing composition includes following parts by weight
Component: 5 parts of purslane extract, 1 part of kawakaw extract, 0.5 part of Gotu Kola P.E, 0.5 part of polygonum cuspidate root extract,
0.5 part of radix scutellariae root extract, 0.5 part of green-tea extract, 0.5 part of glycyrrhiza glabra root extract, 0.5 part of german chamomile flower extract and fan
Repeatedly fragrant 0.5 part of extract.When above-mentioned 9 kinds of natural plant extracts are compounded using aforementioned proportion, anti-acne effect and elimination acne print effect
Fruit is best.
As the preferred embodiment of acne-removing composition of the present invention, the acne-removing composition also includes glycyrrhizic acid two
Potassium, hydroxy phenylpropionyl amine benzoic acid and 10- hydroxydecanoic acid.Above-mentioned three kinds of ingredients can be compounded with above-mentioned eight Plant Extracts, altogether
With the effect for playing anti-inflammation and sterilization.
As the preferred embodiment of acne-removing composition of the present invention, the acne-removing composition also includes dipotassium glycyrrhizinate
0.05~5 parts by weight, 0.1~5 parts by weight of hydroxy phenylpropionyl amine benzoic acid and 0.5~5 parts by weight of 10- hydroxydecanoic acid.
As the preferred embodiment of acne-removing composition of the present invention, the acne-removing composition also includes dipotassium glycyrrhizinate
0.5~2 parts by weight, 0.1~2 parts by weight of hydroxy phenylpropionyl amine benzoic acid and 0.5~2 parts by weight of 10- hydroxydecanoic acid.When these three
When anti-inflammation and sterilization ingredient uses said ratio, the mating reaction better effect with plant extracts.
As the preferred embodiment of acne-removing composition of the present invention, the acne-removing composition also includes dipotassium glycyrrhizinate
1 parts by weight, 1 parts by weight of hydroxy phenylpropionyl amine benzoic acid and 1 parts by weight of 10- hydroxydecanoic acid.When in particular by said ratio, with
The compounding effect of plant extracts is best, and anti-acne effect is best.
As the preferred embodiment of acne-removing composition of the present invention, the acne-removing composition also include glycerine 8~
0.2~1.5 parts by weight of 12 parts by weight, 2~6 parts by weight of butanediol and micromolecule hyaluronic acid sodium.
The invention also discloses a kind of cosmetics comprising the acne-removing composition.
The dosage form of the cosmetics can be cream, lotion and aqua, but be not limited to above-mentioned dosage form.
The beneficial effects of the present invention are: the present invention provides a kind of acne-removing composition, the acne-removing composition includes 9 kinds
Natural plant extracts can give full play to its effect, have preferable antibacterial, antiphlogistic effects, can repair inflammation skin, adjust skin
Skin immunity repairs skin barrier, has certain repair for impaired skin, prevents small pox and back and forth break out, and described dispels
Acne composition is mildly non-stimulated.The present invention also provides a kind of cosmetics comprising the acne-removing composition.
Specific embodiment
To better illustrate the object, technical solutions and advantages of the present invention, below in conjunction with specific embodiment to the present invention
It is described further.
Examples 1 to 10
Examples 1 to 10 is anti-acne essence, and formula is shown in Table 1, the preparation side of anti-acne essence described in Examples 1 to 10
Method comprises the steps of:
(1), by water, glycerine, butanediol, micromolecule hyaluronic acid sodium, purslane extract, dipotassium glycyrrhizinate and 10-
Hydroxydecanoic acid is added to the container, and is warming up to 75~80 DEG C, and to being uniformly mixed, heat preservation 30min sterilizing is standby for stirring at 1500r/min
With being denoted as mixed liquor A.
(2), when liquid A to be mixed is cooled to 45~55 DEG C, hydroxy phenylpropionyl amine benzoic acid, Gotu Kola P.E, tiger is added
Cane root extract, radix scutellariae root extract, green-tea extract, glycyrrhiza glabra root extract and german chamomile flower extract and rosemary extract
Object stirs evenly at 1500r/min, is denoted as mixed liquid B.
(3), when liquid B to be mixed is cooled to 40 DEG C or less, kawakaw extract is added and is stirred in 1500-1800r/min
It mixes uniformly to get the anti-acne essence.
The formula of anti-acne essence described in 1 Examples 1 to 10 of table
Embodiment 11
Product Safety evaluation (human skin pastes spot experiment)
Tested crowd's number: 60 people；Between 20-50 years old age；Health status: skin health of being tried, no skin disease mistake
Quick history meets subject and volunteers inclusion criteria.Grouping, 10 groups, every group of 6 people.
Patch spot method: selecting qualified spot tester, with closed patch experiment method, by tested material about 0.020g~
For 0.025g drop in spot tester, external application special adhesive tape is covered on subject back, and tested material is removed after 24 hours, after removing respectively
0.5, observation dermoreaction in 6,12,24,48 hours, records its knot according to dermoreaction grade scale in " cosmetics health specification "
Fruit.
Test result:
Human skin patch test result is shown: the patch that each group subject passes through the anti-acne essence cream of Examples 1 to 10
Test, wherein 0 skin adverse reaction occurs, illustrates the anti-acne in observation dermoreaction in 0.5,6,12,24,48 hour
Composition and anti-acne essence cream use safe.
Embodiment 12
Bacteriostatic test
Test method:
Referring in National Standard of the People's Republic of China GB15797-2002 " Disposable Sanitary Accessory sanitary standard "
Appendix C 4 " stripping property resists (suppression) bacterium product bacteriostasis property test method ".
For trying strain:
Staphylococcus aureus ATCC6538；Pseudomonas aeruginosa ATCC 9027；Escherichia coli ATCC 8739；Candida albicans
ATCC10231；Microsporon furfur；Propionibacterium acnes.
Culture medium and condition of culture:
(37 DEG C, 48h culture, are used for staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli to ordinary nutrient agar culture medium
Culture)；Sabouraud's agar (30 DEG C, 3 days are cultivated, and Candida albicans culture is used for)；Improvement is husky to protect Ruo Shi agar medium
(30 DEG C, 3 days are cultivated, and microsporon furfur culture is used for): (37 DEG C, 48h Anaerobic culturel are used for acne third to dextrose broth
Acidfast bacilli culture).
Operating procedure:
(1) test organisms for 24 hours washed down with 0.03mol/L PBS by (bacterium) and 5 days (fungi) cultures, is made 106cfu/mL
Bacteria suspension.
(2) it takes test article 1g that above-mentioned bacteria suspension 0.1mL even spread mixing is added, after starting timing 20min, is added
9mL 0.03mol/L PBS is mixed well, and after making appropriate dilution, takes wherein 2~3 dilutions, 1mL is taken to be placed in two respectively
In parallel plate, corresponding culture medium difference Hybrid NC machine tool is added.Make colony count.The above test is repeated 3 times, and takes it average
Number, while setting blank control.
It calculates: X=(A-B)/A × 100%
Wherein: X: bacteriostasis rate, %；
A: control sample averagely recycles bacterium colony；
B: test specimen averagely recycles bacterium colony；
As a result report that bacteriostasis rate >=50%~90%, product have bacteriostasis；Bacteriostasis rate >=90%, product have relatively strong antibacterial
Effect.
Acne-removing evaluation:
Efficacy assessments divide three-level: effective, effective and invalid.When acne-eliminating cosmetic is equal to various strains bacteriostasis rate shown in table 2
Reach >=90%, is judged to significantly effectively to prevent and inhibit whelk to generate；Acne-eliminating cosmetic is to preceding 3 kinds of bacterium shown in table 2
The bacteriostasis rate of kind reaches >=90% and reaches >=50%~90% to the bacteriostasis rate of rear 3 kinds of strains, is judged to effectively preventing
It is generated with inhibition whelk；As long as product for resolving poxes to bacteriostasis rate < 50% of rear 3 kinds of strains, is judged in vain, summarizing such as table 2.
The evaluation of 2 acne-removing of table
Bacteriostatic test the results are shown in Table 3.
3 bacteriostatic experiment result of table
Can be seen that anti-acne essence described in Examples 1 to 10 from the antibacterial result of table 3 effectively can prevent and inhibit
Whelk generates.
Embodiment 13
Using effect evaluation
Evaluation on probation is carried out to anti-acne essence made from Examples 1 to 10.
Subject totally 300 people, wherein 184 people of female, male 116 people, age distribution was at 20~45 years old.Face has apparent acne
And small pox, no skin disease allergies, meet subject and volunteers inclusion criteria.
Subject is divided into 10 groups, every group of 30 people.
Appropriate test sample is taken to be coated in clean affected part, once in the morning and once at night, trying out 28 days is a cycle.It is tested
Person is kept for good daily life system time and eating habit in the trial employment period.After a cycle, the feedback of subject is counted,
Concrete outcome is shown in Table 4.
4 using effect evaluation result of table
From table 4, it can be seen that anti-acne essence of the present invention all has certain anti-acne effect, anti-acne print effect and repairs
Multiple acne flesh effect illustrates also have centainly to impaired skin while anti-acne essence of the present invention has preferable anti-acne effect
Repair, prevent small pox and back and forth break out.Compared with embodiment 6~10, the anti-acne effect and repairing effect of embodiment 2 are more
It is good, illustrate that plant extracts and dipotassium glycyrrhizinate, hydroxy phenylpropionyl amine benzoic acid, 10- hydroxydecanoic acid can be altogether under certain proportion
The effect of same-action performance anti-acne and reparation.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than protects to the present invention
The limitation of range is protected, although the invention is described in detail with reference to the preferred embodiments, those skilled in the art should
Understand, it can be with modification or equivalent replacement of the technical solution of the present invention are made, without departing from the essence of technical solution of the present invention
And range.
Claims (10)
1. a kind of acne-removing composition, which is characterized in that comprising purslane extract, kawakaw extract, Gotu Kola P.E,
Polygonum cuspidate root extract, radix scutellariae root extract, green-tea extract, glycyrrhiza glabra root extract, german chamomile flower extract and rosemary mention
Take object.
2. acne-removing composition as described in claim 1, which is characterized in that the acne-removing composition includes the group of following parts by weight
Point: 0.5~8 part of purslane extract, 0.5~5 part of kawakaw extract, 0.1~2 part of Gotu Kola P.E, polygoni cuspidati,radix mention
Take 0.1~2 part of object, 0.1~2 part of radix scutellariae root extract, 0.1~2 part of green-tea extract, glycyrrhiza glabra root extract 0.1~2
Part, 0.1~2 part of german chamomile flower extract and 0.1~2 part of Rosmarinus officinalis extract.
3. acne-removing composition as described in claim 1, which is characterized in that the acne-removing composition includes the group of following parts by weight
Point: 3~8 parts of purslane extract, 0.5~2 part of kawakaw extract, 0.2~1 part of Gotu Kola P.E, polygoni cuspidati,radix extract
0.2~1 part of object, 0.2~1 part of radix scutellariae root extract, 0.2~1 part of green-tea extract, 0.2~1 part of glycyrrhiza glabra root extract,
0.2~1 part and 0.2~1 part of Rosmarinus officinalis extract of german chamomile flower extract.
4. acne-removing composition as described in claim 1, which is characterized in that the acne-removing composition includes the group of following parts by weight
Point: 5 parts of purslane extract, 1 part of kawakaw extract, 0.5 part of Gotu Kola P.E, 0.5 part of polygonum cuspidate root extract, radix scutellariae
0.5 part of root extract, 0.5 part of green-tea extract, 0.5 part of glycyrrhiza glabra root extract, 0.5 part of german chamomile flower extract and rosemary
0.5 part of extract.
5. acne-removing composition as described in claim 1, which is characterized in that the acne-removing composition also includes dipotassium glycyrrhizinate, hydroxyl
Phenylpropionamide benzoic acid and 10- hydroxydecanoic acid.
6. acne-removing composition as claimed in claim 5, which is characterized in that the acne-removing composition also includes dipotassium glycyrrhizinate 0.05
~5 parts by weight, 0.1~5 parts by weight of hydroxy phenylpropionyl amine benzoic acid and 0.5~5 parts by weight of 10- hydroxydecanoic acid.
7. acne-removing composition as claimed in claim 5, which is characterized in that the acne-removing composition also includes dipotassium glycyrrhizinate 0.5
~2 parts by weight, 0.1~2 parts by weight of hydroxy phenylpropionyl amine benzoic acid and 0.5~2 parts by weight of 10- hydroxydecanoic acid.
8. acne-removing composition as claimed in claim 5, which is characterized in that the acne-removing composition also includes 1 weight of dipotassium glycyrrhizinate
Measure part, 1 parts by weight of hydroxy phenylpropionyl amine benzoic acid and 1 parts by weight of 10- hydroxydecanoic acid.
9. the acne-removing composition as described in any one of claim 1~8, which is characterized in that the acne-removing composition also includes third
0.2~1.5 parts by weight of 8~12 parts by weight of triol, 2~6 parts by weight of butanediol and micromolecule hyaluronic acid sodium.
10. a kind of cosmetics comprising acne-removing composition described in any one of claim 1~9.
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| CN110664700A (en) * | 2019-11-25 | 2020-01-10 | 广州赛莱拉生物基因工程有限公司 | Composition and application thereof in preparation of product for preventing and treating acne |
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