CN110179733A - A kind of kiss-me with anti-acne effect skims the cream off milk liquid and preparation method thereof - Google Patents
A kind of kiss-me with anti-acne effect skims the cream off milk liquid and preparation method thereof Download PDFInfo
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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Abstract
It skims the cream off milk liquid and preparation method thereof the invention discloses a kind of kiss-me with anti-acne effect, the Essence be by kiss-me active constituent after the concentration techniques such as abstraction purification constantly refine, it is formulated again with other formula components by unique preparation process, main component includes: Herba Saxifragae extract, aloe extract, tea tree seed extract, glycerol, carbomer, hyaluronic acid, triethanolamine, EDETATE SODIUM, polyethylene glycol.Plant extracts active constituent in gained Essence can effectively permeate skin to depths, remove free radical, anti-inflammatory, antibacterial, improvement acne flesh and other effects to reach.This product is made of pure natural herbaceous plant extract, almost non-stimulated to skin, has reliable safety, and have preferable economic benefits and good market prospects.
Description
Technical field
The invention belongs to the technical fields of skin care item, and in particular to a kind of kiss-me with anti-acne effect skims the cream off milk liquid
And preparation method thereof.
Background technique
Acne is commonly called as " small pox ", is a kind of chronic inflammation occurred in hair follicle, sebaceous glands, and main cause has sebum secretion
Excessively, clogging of pores and inflammation etc. are dispersed in the greasiness such as face and thoracic dorsal area more.There are self limiting, skin lesion multiform.Long acne on the face
Acne affects the appearance of people, and psychology and social life, may cause it if serious and feels oneself inferior, is irascible, or even depression.Cause
This anti-acne is necessary, and is more important.
There are many kinds of the methods of present anti-acne, the high-intensitive dye for passing through specific wavelength such as laser therapy whelk, this method
Expect laser irradiation, achievees the effect that rapid damage propionic acid whelk bacillus, effectively inhibition bacterial reproduction, eliminate its thorn to tissue
Sharp and destruction, but laser therapy is physical action, cannot fundamentally remove small pox.
Plant anti-acne is to extract anti-acne essence using wild plant in nature, as fructus hippophae, aloe, ocean are sweet
Chrysanthemum, tea tree all have the function of anti-inflammatory anti-acne, but the effect of single plant anti-acne method is unobvious, and action time is longer,
It is unable to reach good effect.Such as a few money product for resolving poxes occurred on the market: perfect Aloe Vera Gel, Pien Tze Huang pearl cream, suitable
Book on Chinese herbal medicine disappears acne maintenance gel etc..Although they have certain anti-acne effect, effect is not obvious, and small pox usually occurs
The case where recurrence.
The Chinese patent literature of publication number CN108096378A (application number 201711434550.4) discloses a kind of anti-acne
Gel and preparation method thereof.This blemish clearing gel is made of raw material below: supermolecule salicylic acid, hamamelis extract, mountain
Tea-seed oil, scutellaria root extract, Fructus Rubi extract, burdock extract, carbomer, moisturizer, chelating agent, pH adjusting agent and
Water.Formula in the invention contains more allergen, and salicylic acid therein is easy excessively removal cuticula, so that skin
The phylactic power defensive power of skin is deteriorated, it may occur however that erythema, itch, shouting pain or allergic phenomena.
Consumer wishes that product for resolving poxes can effectively improve fat secretion, quick sterilization, and cleaning cortex is avoided that small pox simultaneously
Skin sense of discomfort.But many product irritations are too strong on the market, or addition forbidden amphetamine, can cause to the skin of damage
Secondary injury, or even cause serious inflammation.
Summary of the invention
To solve the above-mentioned problems, the purpose of the present invention is to provide a kind of kiss-mes with anti-acne effect to skim the cream off milk
Liquid and preparation method thereof, can effective antibacterial anti-inflammatory, maintain skin water and oil balance, improve fat secretion, to realize oil control and acne removal
The effect of.
The purpose of the present invention is what is be achieved through the following technical solutions:
A kind of kiss-me with anti-acne effect skims the cream off milk liquid, is made of following weight parts raw material:
Further, the acne-removing composition also includes 0.5-3 parts by weight of hydroxy phenylpropionyl amine benzoic acid and 10- hydroxyl
1-5 parts by weight of capric acid.
Further, the acne-removing composition also includes 0.05-5 parts by weight of dipotassium glycyrrhizinate, hydroxy phenylpropionyl amine benzene first
Sour 0.1-5 parts by weight and 0.5-5 parts by weight of 10- hydroxydecanoic acid.
Further, the acne-removing composition also includes 0.5-2 parts by weight of dipotassium glycyrrhizinate, hydroxy phenylpropionyl amine benzene first
Sour 0.1-2 parts by weight and 0.5-2 parts by weight of 10- hydroxydecanoic acid.
Further, the acne-removing composition also includes 1 parts by weight of dipotassium glycyrrhizinate, 1 weight of hydroxy phenylpropionyl amine benzoic acid
Measure part and 1 parts by weight of 10- hydroxydecanoic acid.
Further, the acne-removing composition also includes 8-12 parts by weight of glycerine, 2-6 parts by weight of butanediol and small point
Sub- 0.2-1.5 parts by weight of hyaluronic acid.
Further, the Herba Saxifragae extract the preparation method is as follows: by dry kiss-me, grind and be slurried, remove fiber
Matter alcohol precipitation, centrifugal filtration, volume fraction of ethanol 90% are 1:30 with feed liquid mass ratio, at 100 DEG C of temperature, are mentioned with Soxhlet
It takes device to flow back, extracts 3 times, rotary evaporation concentrated extracting solution to paste, go to drying in baking oven, seal cryo-conservation to get tiger
Auricled Hedyotis Herb extract.
Further, the aloe leaf extract the preparation method is as follows: fresh picking Chinese aloe leaf clean surface mud
Sand is removed the peel after draining, and pulp fraction is cut into small fourth, the length of the small fourth is no more than 3cm；And water bath processing is carried out,
Bath temperature is 60 DEG C；Filtering is to get extract solution from aloe.
Further, the tea tree seed extract the preparation method is as follows: tea seed is stored in after drying and cooling
In 0 DEG C~30 DEG C of temperature environment, using the biochemical basis of vegetable seeds afterripening, promote tea seed after-ripening；Afterwards by oil tea
Seed drying, drying scale are 600t/d；The tea seed of drying carries out stone through seed selection, cleaning classification, separation of peeling off, and magnetic separation is de-
Iron；The tea seed of drying is put into cold pressing expeller, and entering to squeeze temperature is 70 DEG C~80 DEG C；It is respectively put into water, methanol and petroleum ether and extracts 3
Secondary, 3 times extraction time is 16min；Wherein ratio of water to material 0.9:1, the molten material ratio 5:1 of methanol, the molten material ratio 5:1 of petroleum ether；Gained produces
Object is tea tree seed extract.
It skims the cream off milk the preparation method of liquid the invention also includes a kind of kiss-me with anti-acne effect, which is characterized in that
The following steps are included:
(1) by 5-10 parts by weight Herba Saxifragae extracts, 2-5 parts by weight aloe extracts, 0.5-1.0 parts by weight tea trees
Seed extract, 0.1-0.5 parts by weight polyethylene glycol deionized water dissolving of 2 parts by weight, are mixed to get solution A；
(2) by 7-15 parts by weight of glycerin and 1.0-5.0 parts by weight carbomers, 0.5-1.0 parts by weight hyaluronic acids with 2
The deionized water dissolving of parts by weight, obtains B solution；
(3) after mixing A, B solution, 0.5-1.0 parts by weight EDETATE SODIUMs, 0.1-1.0 parts by weight triethanolamines are added
With remaining deionized water, finished product is obtained after mixing.
Beneficial effects of the present invention:
1, Essence of the invention easily absorbs, can improve skin quality, has good dewrinkling spot-eliminating, soft whitening to skin
Effect, while eye skin situation can be improved in a short time, and can be used for a long time, and this Essence can directly and its
He is used in mixed way cosmetics.
2, present invention employs a variety of natural herbal extracts, non-stimulated to skin, and there is anti-inflammatory anti-itch, anti-acne to protect
The multi-efficiencies such as wet, inhibition small pox regeneration, antibacterial；It is suitble to any skin quality, sensitive skin can also be safe to use；
3, the natural material such as kiss-me, aloe, saussurea involucrata etc. that the present invention uses, extract manufacture craft is simple, time-consuming
It is short；
4, the distinctive Herba Saxifragae extract of the present invention not only has good anti-inflammatory effects, additionally it is possible to impaired skin is repaired,
Good care is brought to skin；
5, the present invention can be directly added into the mixed use of other cosmetics, and without any side effects.These are beneficial to effect
Fruit is all that comparison is empty, and taking can use inside many patents, either with or without for the distinctive effect of our patents.
6, the medicinal efficacy of Herba Saxifragae extract is very outstanding, has heat-clearing, removing pattogenic heat from the blood and toxic material from the body and controls cough due to wind-heat evil, wind fire
Toothache, rubella itch, hemorrhoid gall, insect-bite, traumatic hemorrhage, otitis media acuta, cough due to wind-heat evil etc..Herba Saxifragae extract institute
All containing a variety of flavone compounds such as Kaempferol, Bergenin, Quercetin, quercitin, gallic acid, protocatechuic acid and sitosterol
Have the effects that different degrees of anti-inflammatory, antiallergy, free radical resisting, anti-oxidant, antibacterial, can be used for treating acne, acne etc..Reed
The polysaccharide and multivitamin contained in luxuriant growth has good nutrition to human skin, moistens, whitening effect.Contained by aloe extract
The substances such as Aloin A have viral infection resisting, and anti-inflammation and sterilization, heat absorption detumescence, softening skin, the function of keeping cell viability promote
The effect restored into wound healing.Therefore aloe extract is while playing moisture-keeping function, it may also be used for treatment scytitis,
Such as acne, freckle, acne.Contain squalene in tea tree seed extract, can be used for various ischemic diseases, heart disease, hepatitis and
The prevention and treatment of cancer can prevent cancer metastasis, be a kind of avirulent hardening agent with anticancer, anti-aging effects.Can also moisturizing,
Skin maintenance and cosmetic benefits, anti-inflammation and sterilization.
Detailed description of the invention
Fig. 1 is the test result of the opposite percentage of water loss of embodiment 1-3 and comparative example 1-2.
Specific embodiment
In order to better understand the present invention, below by embodiment to the present invention into further explanation, embodiment is served only for
It explains the present invention, any restriction can't be constituted to the present invention.
The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention..Unless otherwise specified, embodiment
Used in the conventional means that are well known to those skilled in the art of technological means, raw materials used is commercial goods.
Embodiment 1
A kind of kiss-me with anti-acne effect of the present embodiment skims the cream off milk liquid, and include following raw materials according: kiss-me is extracted
5 parts of object, 3 parts of extract solution from aloe, 0.5 part of tea tree seed extract, 7 parts of glycerol, 1.0 parts of carbomer, 0.5 part of hyaluronic acid, three second
0.1 part of hydramine, 0.5 part of EDETATE SODIUM, 0.1 part of polyethylene glycol, 10 parts of deionized water.The acne-removing composition also includes hydroxyphenyl
1 part and 2 parts of 10- hydroxydecanoic acid of propionamide benzoic acid.
Preparation method is as follows:
Step 1: taking dry kiss-me 10.00g, grind and be slurried, and removes cellulosic alcohol precipitation, centrifugal filtration；Volume fraction 90%
Ethyl alcohol 300mL, solid-liquid ratio 1:30, are flowed back with Soxhlet extractor by 100 DEG C of temperature, are extracted 3 times；Rotary evaporation concentration kiss-me mentions
It takes liquid to a certain concentration, seals cryo-conservation, the Herba Saxifragae extract being finally made in raw material.
The Folium Aloe extract the preparation method is as follows:
Step 2: the Chinese aloe leaf of fresh picking carry out washing removal surface silt, drain after remove the peel, retain pulp fraction；
Dicing treatment is carried out to the pulp after peeling, is cut into small fourth, the length of the small fourth is no more than 3cm；To being cut into small fourth
Aloe pulp carries out water bath processing, and bath temperature is 60 DEG C；Filtering, i.e. acquisition extract solution from aloe.
Step 3: tea seed needs store after drying and cooling, and storage is generally in 0 DEG C~30 DEG C of temperature environment
In, using the biochemical basis of vegetable seeds afterripening, promote tea seed after-ripening.Drafting tea seed drying scale is 600t/d；
The tea seed of drying storage storage carries out stone, magnetic separation deferrization through seed selection, cleaning classification, separation of peeling off；Using dedicated cold press
Machine enters to squeeze temperature at 70 DEG C~80 DEG C or so；Extraction time 16min, ratio of water to material 0.9:1, the molten material ratio 5:1 of methanol, petroleum ether are molten
Material compares 5:1；Products therefrom is tea tree seed extract.
Step 4: (1) by Herba Saxifragae extract, aloe extract, tea tree seed extract, polyethylene glycol with 2 parts go from
Sub- water dissolution, is mixed to get solution A；
(2) by glycerol and 2 parts carbomer, hyaluronic acid of deionized water dissolving, B solution is obtained；
(3) after mixing A, B solution, EDETATE SODIUM, triethanolamine and remaining deionized water is added, after mixing
To finished product.
Embodiment 2
Anti-acne essence, the difference of the present embodiment and embodiment 1 is prepared according to preparation method similar to Example 1
It is raw material difference, the present embodiment includes following raw materials according: 5 parts of Herba Saxifragae extract, 3 parts of extract solution from aloe, tea tree seed extract
0.58 part, 8 parts of glycerol, 1.4 parts of carbomer, 0.5 part of hyaluronic acid, 0.13 part of triethanolamine, 0.53 part of EDETATE SODIUM, poly- second two
0.1 part of alcohol, 25 parts of deionized water, the acne-removing composition also includes 0.1 part of dipotassium glycyrrhizinate, hydroxy phenylpropionyl amine benzoic acid
0.5 part and 3 parts of 10- hydroxydecanoic acid.
Embodiment 3
Anti-acne essence, the difference of the present embodiment and embodiment 1 is prepared according to preparation method similar to Example 1
It is raw material difference, the present embodiment includes following raw materials according: 5 parts of Herba Saxifragae extract, 3 parts of extract solution from aloe, tea tree seed extract
0.58 part, 8 parts of glycerol, 1.4 parts of carbomer, 0.5 part of hyaluronic acid, 0.13 part of triethanolamine, 0.53 part of EDETATE SODIUM, poly- second two
0.1 part of alcohol, 18 parts of deionized water, the acne-removing composition also includes 8 parts of glycerine, 2 parts of butanediol and micromolecule hyaluronic acid
0.2 part.
Comparative example 1
The Essence of this comparative example, ingredient and embodiment 1 are completely the same, and difference is only that: not including hydroxy phenylpropionyl
Amine benzoic acid and 10- hydroxydecanoic acid.
Comparative example 2
The Essence of this comparative example, ingredient and embodiment 2 are completely the same, and difference is only that: do not include dipotassium glycyrrhizinate,
Hydroxy phenylpropionyl amine benzoic acid and 10- hydroxydecanoic acid.
Comparative example 3
The Essence of this comparative example, ingredient and embodiment 2 are completely the same, and difference is only that: not including glycerine, fourth two
Pure and mild micromolecule hyaluronic acid.
Contrast on effect example
In order to verify it is of the present invention have the effect of the Essence of acne-removal function, will be made below clinical trial:
One, moistening effect is tested: the experiment of gravimetric detemination percentage of water loss
1, it test specimen: is extracted with the kiss-me with anti-acne effect that embodiment 1-3 and comparative example 1-3 are prepared
Essence is as sample to be tested.
2, test method: preparing gravimetric detemination moisturizer percentage of water loss before test must carry out in a constant temperature, constant humidity environment.
1) proxima luce (prox. luc) is tested, the unsaturated carbonate potassium solution of certain volume is placed in drier bottom, is greater than liquid depth
1cm places porous barrier thereon, closes the lid, and keeps sealing state, is placed in 25 DEG C of environment, to water vapor in air point
Press it is constant after, about 43% relative humidity can be maintained.
2) a certain amount of sample is weighed, the glass plate (relative humidity of 5cm × 5cm for posting 3M adhesive tape is coated uniformly on.Sample
Dosage is about 2mg/cm2, it is placed in the drier for filling potassium carbonate saturated aqueous solution (RH43%), after the placement section time (2h,
4h, 6h, 8h) weigh sample quality, test, be averaged three times in parallel.
Percentage of water loss calculation formula:
M1The quality of sample before placing；
M2The quality of sample after placement.
3, result: the moistening effect test result of embodiment 1-3 and comparative example 1-3, HA is shown in Fig. 1.
The corresponding comparison of 3, No. 4 lines of the line corresponding embodiment 2,3 of Line 1 corresponding embodiment 1,2 line corresponding embodiment in Fig. 1
1, No. 5 lines of embodiment correspond to 2, No. 6 lines of comparative example and correspond to comparative example 3, and HA is hyaluronic acid.
It can be seen from figure 1 that the opposite percentage of water loss of embodiment and comparative example is both less than transparent compared with hyaluronic acid (HA curve)
Matter acid, wherein the opposite percentage of water loss of embodiment 2 is lower, and moistening effect is preferable, illustrates that the Essence all has preferable moisturizing
Effect.
Two, human skin patch spot experiment
1, trial target: the Herba Saxifragae extract essence with anti-acne effect that embodiment 1-3 and comparative example 1-3 is prepared
Liquid
Tested crowd's number: 60 people, between 20-50 years old age；
Health status: skin health of being tried, no skin disease allergies meet subject and volunteer inclusion criteria.Grouping, 6
Group, every group of 10 people.
2, it pastes spot method: selecting qualified spot tester, with closed patch experiment method, tested material embodiment 1-6 is made
Standby Essence about 0.020g -0.025g drop is in spot tester, and external application special adhesive tape is covered on subject back, after 24 hours
Tested material is removed, observation dermoreaction in 0.5,6,12,24,48 hour after removing respectively, according to skin in " cosmetics health specification "
Skin reaction grade scale records its result.
3, test result: human skin patch test result is shown: the spot that each group subject passes through implementation anti-acne essence
Patch test, wherein 0 skin adverse reaction occurs, illustrates described dispel in observation dermoreaction in 0.5,6,12,24,48 hour
Acne Essence uses safe.
Anti-acne effect test
1, object: the crowd of 16-45 years old age face head's small pox is tried out, facial skin status and appearance is greasy itch, acne
Acne.
2, test method: every group of 100 people, totally 3 groups, respectively product 30 days made from test example 1-3, observation and sense
By using effect.
After volunteer cleans face, above-mentioned Essence about 3mL is poured in cotton pads, soak cotton pads but will not be dripped
It falls, and determines cotton piece direction, so that cotton piece, is all covered on the skin surface of acne by cotton piece fiber orientation and finger vertical,
It gently presses with finger, gently wipes, so that Essence penetrates into skin, it is each using once daily morning and evening, adhere to using one
It a month, at least checks weekly once to understand whether there is or not whole body and local adverse reaction, must not be dispelled using others during test
Small pox product or hormone product, in the state of the 30th day detection skin.
3, test result
Anti-acne effect test assessment result such as the following table 1:
Table 1. have anti-acne effect kiss-me skim the cream off milk liquid try out (one month) feedback conclusive table
As 1 anti-acne effect test result of table is shown: each group subject is tested by implementing the smearing of anti-acne essence, 30
In it observation anti-acne effect, test crowd facial small pox within the testing time is all dispelled substantially, wherein 0 skin occurs
Adverse reaction illustrates that this Essence has significant effect to anti-acne.
Three, bacteriostatic test
1, test material
1) for trying strain: staphylococcus aureus ATCC6538；Pseudomonas aeruginosa ATCC 9027；Escherichia coli ATCC
8739；Candida albicans ATCC10231；Microsporon furfur；Propionibacterium acnes.
Culture medium and condition of culture: ordinary nutrient agar culture medium (37 DEG C, 48h culture, for staphylococcus aureus,
Pseudomonas aeruginosa, Escherichia coli culture)；Sabouraud's agar (30 DEG C, 3 days are cultivated, and Candida albicans culture is used for)；Improvement is husky
Protect Ruo Shi agar medium (30 DEG C, 3 days are cultivated, and microsporon furfur culture is used for): dextrose broth (37 DEG C, 48h anaerobism
Culture is used for propionibacterium acnes culture).
2, test method: referring to National Standard of the People's Republic of China GB15797-2002 " Disposable Sanitary Accessory
Appendix C 4 " stripping property resists (suppression) bacterium product bacteriostasis property test method " in sanitary standard ".
1) test organisms for 24 hours washed down with 0.03mol/L PBS by (bacterium) and 5 days (fungi) cultures, and 106cfu/mL bacterium is made
Suspension.
2) it takes test article 1g that above-mentioned bacteria suspension 0.1mL even spread mixing is added, after starting timing 20min, 9mL is added
0.03mol/L PBS is mixed well, and after making appropriate dilution, takes wherein 2-3 dilutions, and 1mL is taken to be placed in two in parallel respectively
In plate, corresponding culture medium difference Hybrid NC machine tool is added.Make colony count.The above test is repeated 3 times, and takes its average, together
When set blank control.
3) bacteriostasis rate calculation formula: X=(A-B)/A × 100%
Wherein: X；Bacteriostasis rate: %；
A: control sample averagely recycles bacterium colony；
B: test specimen averagely recycles bacterium colony；
3, test result
Bacteriostatic test result such as the following table 2:
The antibacterial inspection result of table 2.
It can be seen that the Essence with anti-acne effect that embodiment 1-3 is prepared from the data of table 2 and have and preferably kill
Bacterium fungistatic effect.
The above description is only an embodiment of the present invention, is not intended to limit the scope of the invention, all to utilize this hair
Equivalent structure or equivalent flow shift made by bright description is applied directly or indirectly in other relevant technology necks
Domain is included within the scope of the present invention.
Claims (10)
- The liquid 1. a kind of kiss-me with anti-acne effect skims the cream off milk, which is characterized in that be made of following weight parts raw material:5-10 parts of Herba Saxifragae extract；2-5 parts of aloe extract；0.5-1.0 parts of tea tree seed extract；7-15 parts of glycerol；1.0-5.0 parts of carbomer；0.5-1.0 parts of hyaluronic acid；0.1-1.0 parts of triethanolamine；0.5-1.0 parts of EDETATE SODIUM；0.1-0.5 part of polyethylene glycol；10-30 parts of deionized water.
- 2. a kind of kiss-me with anti-acne effect skims the cream off milk liquid according to claim 1, it is characterised in that: the anti-acne Composition also includes 0.5-3 parts by weight of hydroxy phenylpropionyl amine benzoic acid and 1-5 parts by weight of 10- hydroxydecanoic acid.
- 3. a kind of kiss-me with anti-acne effect skims the cream off milk liquid according to claim 1, which is characterized in that the anti-acne Composition also includes 0.05-5 parts by weight of dipotassium glycyrrhizinate, 0.1-5 parts by weight of hydroxy phenylpropionyl amine benzoic acid and the 10- hydroxyl last of the ten Heavenly stems Sour 0.5-5 parts by weight.
- 4. a kind of kiss-me with anti-acne effect skims the cream off milk liquid according to claim 1, which is characterized in that the anti-acne Composition also includes 0.5-2 parts by weight of dipotassium glycyrrhizinate, 0.1-2 parts by weight of hydroxy phenylpropionyl amine benzoic acid and the 10- hydroxyl last of the ten Heavenly stems Sour 0.5-2 parts by weight.
- 5. a kind of kiss-me with anti-acne effect skims the cream off milk liquid according to claim 1, which is characterized in that the anti-acne Composition also includes 1 parts by weight of dipotassium glycyrrhizinate, 1 parts by weight of hydroxy phenylpropionyl amine benzoic acid and 1 parts by weight of 10- hydroxydecanoic acid.
- 6. a kind of any one of -5 kiss-mes with anti-acne effect skim the cream off milk liquid according to claim 1, which is characterized in that The acne-removing composition also includes 8-12 parts by weight of glycerine, 2-6 parts by weight of butanediol and micromolecule hyaluronic acid 0.2- 1.5 parts by weight.
- 7. a kind of any one of -5 kiss-mes with anti-acne effect skim the cream off milk liquid according to claim 1, which is characterized in that The Herba Saxifragae extract the preparation method is as follows: by dry kiss-me, grind and be slurried, remove cellulosic alcohol precipitation, centrifugal filtration, second Alcohol volume fraction is 90%, is 1:30 with feed liquid mass ratio, at 100 DEG C of temperature, is flowed back with Soxhlet extractor, is extracted 3 times, rotation Turn evaporation and concentration extracting solution to paste, then dries, seal cryo-conservation to get Herba Saxifragae extract.
- 8. a kind of any one of -5 kiss-mes with anti-acne effect skim the cream off milk liquid according to claim 1, which is characterized in that The aloe leaf extract the preparation method is as follows: fresh picking Chinese aloe leaf clean surface silt, removed the peel after draining, by fruit Small fourth is cut into meat part, and the length of the small fourth is no more than 3cm；And water bath processing is carried out, bath temperature is 60 DEG C；It crosses Filter is to get extract solution from aloe.
- 9. a kind of any one of -5 kiss-mes with anti-acne effect skim the cream off milk liquid according to claim 1, which is characterized in that The tea tree seed extract the preparation method is as follows: tea seed after drying and cooling, is stored in 0 DEG C~30 DEG C of temperature ring In border, using the biochemical basis of vegetable seeds afterripening, promote tea seed after-ripening；Tea seed is dried afterwards, drying scale is 600t/d；The tea seed of drying carries out stone, magnetic separation deferrization through seed selection, cleaning classification, separation of peeling off；The tea seed of drying is put into Cold pressing expeller, entering to squeeze temperature is 70 DEG C~80 DEG C；It is respectively put into water, methanol and petroleum ether and extracts 3 times, 3 times extraction time is 16min；Wherein ratio of water to material 0.9:1, the molten material ratio 5:1 of methanol, the molten material ratio 5:1 of petroleum ether；Products therefrom is tea tree seed extract.
- The preparation method of liquid 10. a kind of kiss-me with anti-acne effect skims the cream off milk, which comprises the following steps:(1) 5-10 parts by weight Herba Saxifragae extracts, 2-5 parts by weight aloe extracts, 0.5-1.0 parts by weight Seed of Camellia Sinensis are mentioned Object, 0.1-0.5 parts by weight polyethylene glycol deionized water dissolving of 2 parts by weight are taken, solution A is mixed to get；(2) by 7-15 parts by weight of glycerin and 1.0-5.0 parts by weight carbomers, 0.5-1.0 parts by weight hyaluronic acids, 2 weight The deionized water dissolving of part, obtains B solution；(3) after mixing A, B solution, 0.5-1.0 parts by weight EDETATE SODIUMs, 0.1-1.0 parts by weight triethanolamines is added and remain Remaining deionized water, obtains finished product after mixing.
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