CN108210389A - A kind of oil control and acne removal composition - Google Patents
A kind of oil control and acne removal composition Download PDFInfo
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- CN108210389A CN108210389A CN201810192229.8A CN201810192229A CN108210389A CN 108210389 A CN108210389 A CN 108210389A CN 201810192229 A CN201810192229 A CN 201810192229A CN 108210389 A CN108210389 A CN 108210389A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
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Abstract
The invention discloses a kind of oil control and acne removal compositions, including moisturizer, anti-inflammatory agent, Chinese herbal medicine oil-control mixture, antiseptic ingredient, wherein Chinese herbal medicine oil-control mixture include haw thorn extract, evergreen boisiana extract, Herba Saxifragae extract, two kinds or more in Semen Benincasae extract.The effect of ingredient makes the composition of the present invention have good antibacterial anti-inflammatory, maintains skin water and oil balance, improves the effect of fat secretion, achieve the purpose that oil control and acne removal, and composition is applied in cosmetics, can assign cosmetics good oil control and acne removal effect.
Description
Technical field
The present invention relates to cosmetic fields, and in particular to a kind of oil control and acne removal composition.
Background technology
Acne is the chronic inflammation of a kind of hair follicle, sebaceous glands, occurs mainly in the greasiness such as face and thoracic dorsal area.Have from limit
Property, skin lesion multiform.Such as acne, papule, warts, tubercle.Seborrhea is often accompanied by, after puberty, recovery from illness or mitigation mostly.In the past
Acne is considered as disease of sebaceous glands, and substantial damage includes hair follicle, sebaceous glands and epidermis.In addition, normal parasitism Cuo in hair follicle
Sore propionic acid Propiobacterium, pityrosporum furfur and staphylococcus epidermis etc., when free aliphatic acid increases, propionic acid Propiobacterium cannot
It generates enough enzymes and decomposes sebum, the aliphatic acid of stasis makes perifollicolar generate nonspecific inflammation reaction.Propionic acid Propiobacterium
Low molecular polypeptide can be also secreted, neutrophil leucocyte is attracted to enter hair follicle, it is caused to hydrolyze enzyme r e lease, makes follicular epithelium leakage broken
Split, hair follicle content caused to enter dermal tissue around, cause from simple inflammation to papule, abscess, tubercle, tumour a system
Row clinical manifestation.It is caused by many reasons, and seriously affects beauty or even the life of people.Anti-acne is necessary, even more heavy
It wants.There are many product for resolving poxes on the market, and main component is Chinese herbal medicine, generated with salubrious oil-control prevention small pox, slowly
The internal environment of slow conditioning skin is finally reached the purpose of anti-acne.
Consumer wishes that product for resolving poxes can effectively improve fat secretion, quick sterilization, and cleaning cortex is avoided that small pox simultaneously
Skin sense of discomfort.But many product irritations are too strong on the market or add forbidden amphetamine, the skin of damage can be given to cause
Secondary injury or even the serious inflammation of initiation.
Invention content
The purpose of the present invention is to provide a kind of oil control and acne removal composition, can effective antibacterial anti-inflammatory, skin water oil is maintained to put down
Weighing apparatus improves fat secretion, the effect of so as to fulfill oil control and acne removal.
To achieve the above object, the present invention provides following technical solution：
A kind of oil control and acne removal composition includes the component of following mass parts：
Wherein, Chinese herbal medicine oil-control mixture includes haw thorn extract, evergreen boisiana extract, Herba Saxifragae extract, waxgourd seed
Two kinds or more in extract.
Further, the composition includes the component of following parts by weight：
Wherein, Chinese herbal medicine oil-control mixture includes haw thorn extract, evergreen boisiana extract, Herba Saxifragae extract, waxgourd seed
Two kinds or more in extract.
Further, the composition includes the component of following parts by weight：
Wherein, Chinese herbal medicine oil-control mixture includes haw thorn extract, evergreen boisiana extract, Herba Saxifragae extract, waxgourd seed
Two kinds or more in extract.
In addition, the moisturizer include creatine, soybean protein, saualane, urea, one kind in hyaluronic acid or with
On；
The anti-inflammatory agent include carthamin yellow, dipotassium glycyrrhizinate, allantoin, one kind in Pu pollen extract or with
On；
The antiseptic include ursolic acid, oldenlandia diffusa flavones, honeysuckle flower extract, one kind in tea tree ethereal oil or
More than；
Composition of the present invention can be used for cosmetics, can such as be used as additive for oil-control, anti-acne class product or wash
Face milk.
Compared with prior art, it is the device have the advantages that as follows：
The composition addition moisturizer of the present invention can lock skin moisture, maintain skin water and oil balance, have certain oil-control to imitate
Fruit；Add antiseptic can effective bactericidal, if honeysuckle flower extract is to acne bacillus, staphylococcus aureus and Pseudomonas aeruginosa
There is a good inhibiting effect, reduce bacterium infection, and then and reduce the growth of small pox；Addition anti-inflammatory agent can inhibit inflammatory factor to release
It puts, increases the effect of the anti-environmental stimuli of skin, such as carthamin yellow inflammatory reaction capable of inhibiting cell reduces inflammatory cytokine
Expression mitigates skin inflammation, and Pu pollen extract promotes luciferase, has anti-inflammatory, prevents dermatitis；Add Chinese herbal medicine
Oil-control mixture effectively adjusts water and oil balance, and if haw thorn extract has facilitation to the synthesis of brain amidase, secretion can be changed
Sebum composition, ivy extract play the role of inhibit sebum secretion, control hypersecretion grease；The effect of ingredient makes this hair
Bright composition has good antibacterial anti-inflammatory, maintains skin water and oil balance, improves the effect of fat secretion, reach oil control and acne removal
Purpose, and composition is applied in cosmetics, can assign cosmetics good oil control and acne removal effect.
Specific embodiment
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
By 5 grams of haw thorn extracts, 10 grams of creatines, 3 grams of anthoxanthins, 4 grams of oldenlandia diffusa flavones and 78 grams of deionized waters
It is placed in mixer, is uniformly mixed, you can obtain oil control and acne removal composition 1.
Embodiment 2
9 grams of evergreen boisiana extracts, 14 grams of soybean proteins, 6 grams of dipotassium glycyrrhizinates, 6 grams of honeysuckle flower extracts and 65 grams are gone
Ionized water is placed in mixer, is uniformly mixed, you can obtains oil control and acne removal composition 2.
Embodiment 3
By 15 grams of Herba Saxifragae extracts, 16 grams of hyaluronic acids, 8 grams of Pu pollen extracts, 8 grams of tea tree ethereal oils and 53 grams go from
Sub- water is placed in mixer, is uniformly mixed, you can obtains oil control and acne removal composition 3.
The inhibition of propionibacterium acnes is tested
(1) test specimen：Oil control and acne removal composition, 3 groups of the propionibacterium acnes bacterial strain of Examples 1 to 3 preparation (suffer from by acne
It is isolated at person's skin lesion)；
(2) test method：
1. the culture of anaerobic bacteria, separation, identification：THl0 cultures will be inoculated at patients with acne skin lesion by isolated sample
In base, with airbag method, 37 DEG C of culture 72h in anaerobic jar are placed in, indicator are made with methylene blue, palladium grain is pierced for catalysis.
2. the separation of anaerobic bacteria
Picking single bacterium colony turns 2 pieces of tablets, and one piece is placed in anaerobic jar, the lower 37 DEG C of pure cultures of anaerobic condition；Another piece with
37 DEG C of aerobic cultures；Result is observed after 48h.
3. the identification of anaerobic bacteria
Without bacterial growth under aerobic culture；
Occur uniform form, canescence, the circle of tiny, diameter about 1.0mm protrusions, edge on the tablet of Anaerobic culturel slightly
Bacterium colony is made microscopy, visible chromabacterium biolaceum under mirror by neat bacterium colony.It is micro-bend in rodlike or rod-shaped, can one end blunt circle, one end attenuates,
Coloring is not deep, and cell is single, can arrange or arrange in pairs as the shapes such as " people ", " v ".It is tested again through oxytolerant, catalase test, indoles
Experiment, biochemical serial test for identification are propionibacterium acnes.
4. anaerobism drug sensitive test
Inoculation：1 colony inoculation in the bacterium colony more than picking cultivated is on LB plating mediums, 37 DEG C of aerobic trainings
It supports for 24 hours, by aerobic culture, propionibacterium acnes are rinsed with sterile saline for 24 hours, and flushing liquor is put into sterile test tube；Using wheat
Family name's turbidimetry is than turbid, and opacity tube is with shaking 12 times is before needed, first than turbid to 3 × 108/ mL, then with normal saline dilution to 106/ mL is standby
With.
LB plating mediums are inoculated with：The swab stick of sterilizing is dipped into bacterium solution, extra bacterium solution is gone in being squeezed on tube wall, is trained in LB tablets
Even spread on base is supported, and a circle is swept along plate edge ring, covers plate, dry 2min.Sterile steel bowl (a diameter of 6mm) is light
It is put on plating medium, fills it up with the oil control and acne removal composition of Examples 1 to 3 preparation respectively, be put into 37 DEG C of aerobic cultures for 24 hours,
It was found that continue 37 DEG C of aerobic cultures without bacterial growth in plate and see there is inhibition zone to be formed afterwards for 24 hours.Antibacterial circle diameter is surveyed, by 3 groups of suppressions
Bacterium loop diameter value is averaged.
Result of the test：
Chinese medicine antibacterial susceptibility grade classification, with reference to corresponding antibiotic standard ".Inhibition zone diameter>20mm is Gao Min, 10~
20mm is quick in being,<10mm is drug resistance, and the results are shown in Table 1 for specific observation.
Table 1
It can be seen that oil control and acne removal composition prepared by Examples 1 to 3 has propionibacterium acnes from the result of the test of table 1
There is high quick effect (antibacterial circle diameter>20mm), illustrate oil control and acne removal composition of the present invention can effective antibacterial, avoid bacterium sense
Dye.
Embodiment 4
A kind of preparation method of oil control and acne removal facial cleanser is as follows：It is according to mass percent, 3% saualane, 2% spermaceti is hard
Lipidol, 4% dimethyl silicone polymer, 2% sodium lauryl sulfate, 4% alkyl sulfate, 2% myristic acid, 2.5%PEG-20
In methyl sesquistearate, 0.01% methyl hydroxybenzoate and 0.01% Nipasol input oil phase pot, 70 DEG C are heated to, etc.
It is kept the temperature after all components dissolving, oil phase is made；By 12.5% glycerine, 2% stearic acid, 0.3% carbomer, 0.04% xanthans and
57.44% deionized water is put into successively in water phase pot, is heated to 70 DEG C, heat preservation 15min makes it fully dissolve, and oil phase is made；It will
Water phase, oil phase are pumped into successively in emulsification pot, and homogeneous 5min, stir speed (S.S.) 2000r/min, then insulated and stirred 15min, is stirred
Rate is mixed as 30r/min；40 DEG C are cooled to, 0.2% potassium hydroxide is added in, stirs evenly；Add in 8% above-mentioned oil control and acne removal combination
Object 1 stirs evenly.
Embodiment 5
A kind of preparation method of oil control and acne removal lotion is as follows：According to mass percent, by 5% trehalose, 8% glycerine,
0.05% xanthans, 0.05%EDTA disodiums and 66.7% deionized water are mixed and heated to 85 DEG C, and stirring and dissolving is uniform to obtain water phase；
By 3% methyl sesquistearate, 2% cetostearyl alcohol, 3% isopropyl myristate, 4% saualane and 3% poly- two
Methylsiloxane is mixed and heated to 85 DEG C, and stirring and dissolving is uniform to obtain oil phase；Oil phase is added in water phase, then homogeneous 10min is stirred
It mixes and is cooled to 40 DEG C, add in 5% oil control and acne removal composition 2 and 0.2% Phenoxyethanol, stir evenly, cooling.
Embodiment 6
A kind of preparation method of oil control and acne removal frost is as follows：According to mass percent, by 8% glycerine, 0.5% carbomer,
0.2% xanthans, 1.5% cetearyl glucoside and 81.6% deionized water are uniformly mixed, and are heated to 82 DEG C, stirring heat preservation
30min obtains water phase to being completely dissolved；Simultaneously by 2% octyl dodecanol myristinate, 2% Butyrospermum parkii fruit fat, 3% poly- two
Methylsiloxane is heated to 82 DEG C, keeps the temperature 25-35 minutes, obtains oil phase；Water phase and oil phase are uniformly mixed, the homogenized milk at 80 DEG C
Change 15min, deaeration；45 DEG C are cooled to, 2% oil control and acne removal composition 3 is added and 0.2% Phenoxyethanol is uniformly mixed, is cooled down
Discharging.
Human efficiency evaluates
Object on probation：The crowd of 20-45 Sui face head's small pox of age, facial skin status and appearance is greasy itch, small pox.
Method：Every group of 20 people, product made from test example 4~6 25 days respectively, while commercially available declare have with a
The cosmetics of oil control and acne removal acne effect are control group.Corresponding product is tested sooner or later daily, must not be used during experiment other
Anti-acne acne product or hormone product, in the state of the 25th day detection skin, as a result such as the following table 2.
Table 2
It can see by table 2：Oil control and acne removal product prepared by embodiment 4~6 is respectively provided with apparent oil-control, anti-acne effect,
And far above commercially available control group.
Above example is merely to illustrate embodiment of the present invention, and there is no the limits having to the present invention in any form
System；It is any to be engaged in professional and technical personnel, it all has the ability using the technology contents having revealed that, some is made to it and changes or repaiies
Decorations become the equivalent embodiment of equivalent variations.According to the technology of the present invention essence, simply modification, equivalent variations are carried out to the present invention
With modification, belong in the range of technical solution of the present invention.
Claims (9)
1. a kind of oil control and acne removal composition, it is characterised in that component is with content：
Above-mentioned is mass parts；
Wherein, Chinese herbal medicine oil-control mixture includes haw thorn extract, evergreen boisiana extract, Herba Saxifragae extract, waxgourd seed extraction
Two kinds or more in object.
2. composition as described in claim 1, it is characterised in that component is with content：
Above-mentioned is mass parts；
Wherein, Chinese herbal medicine oil-control mixture includes haw thorn extract, evergreen boisiana extract, Herba Saxifragae extract, waxgourd seed extraction
Two kinds or more in object.
3. composition as claimed in claim 2, it is characterised in that component is with content：
Above-mentioned is mass parts；
Wherein, Chinese herbal medicine oil-control mixture includes haw thorn extract, evergreen boisiana extract, Herba Saxifragae extract, waxgourd seed extraction
Two kinds or more in object.
4. composition as described in claim 1, it is characterised in that：
The moisturizer includes one or more of in creatine, soybean protein, saualane, urea, hyaluronic acid；
The anti-inflammatory agent includes one or more of in carthamin yellow, dipotassium glycyrrhizinate, allantoin, Pu pollen extract；
The antiseptic include ursolic acid, oldenlandia diffusa flavones, honeysuckle flower extract, one kind in tea tree ethereal oil or with
On.
5. composition as claimed in claim 2, it is characterised in that：
The moisturizer includes one or more of in creatine, soybean protein, saualane, urea, hyaluronic acid；
The anti-inflammatory agent includes one or more of in carthamin yellow, dipotassium glycyrrhizinate, allantoin, Pu pollen extract；
The antiseptic include ursolic acid, oldenlandia diffusa flavones, honeysuckle flower extract, one kind in tea tree ethereal oil or with
On.
6. composition as claimed in claim 3, it is characterised in that：
The moisturizer includes one or more of in creatine, soybean protein, saualane, urea, hyaluronic acid；
The anti-inflammatory agent includes one or more of in carthamin yellow, dipotassium glycyrrhizinate, allantoin, Pu pollen extract；
The antiseptic include ursolic acid, oldenlandia diffusa flavones, honeysuckle flower extract, one kind in tea tree ethereal oil or with
On.
7. such as claims 1 to 3 any one of them composition, it is characterised in that available for cosmetics.
8. such as claims 1 to 3 any one of them composition, it is characterised in that additive can be used as oil-control, anti-acne class
Product.
9. such as claims 1 to 3 any one of them composition, it is characterised in that available for facial cleanser.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810192229.8A CN108210389A (en) | 2018-03-08 | 2018-03-08 | A kind of oil control and acne removal composition |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810192229.8A CN108210389A (en) | 2018-03-08 | 2018-03-08 | A kind of oil control and acne removal composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108210389A true CN108210389A (en) | 2018-06-29 |
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ID=62658167
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| CN201810192229.8A Withdrawn CN108210389A (en) | 2018-03-08 | 2018-03-08 | A kind of oil control and acne removal composition |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110179733A (en) * | 2019-07-10 | 2019-08-30 | 福建师范大学 | A kind of kiss-me with anti-acne effect skims the cream off milk liquid and preparation method thereof |
| CN111110619A (en) * | 2020-02-14 | 2020-05-08 | 广州市科能化妆品科研有限公司 | Oil-control acne-removing composition and application thereof in cosmetics |
-
2018
- 2018-03-08 CN CN201810192229.8A patent/CN108210389A/en not_active Withdrawn
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110179733A (en) * | 2019-07-10 | 2019-08-30 | 福建师范大学 | A kind of kiss-me with anti-acne effect skims the cream off milk liquid and preparation method thereof |
| CN111110619A (en) * | 2020-02-14 | 2020-05-08 | 广州市科能化妆品科研有限公司 | Oil-control acne-removing composition and application thereof in cosmetics |
| CN111110619B (en) * | 2020-02-14 | 2022-06-28 | 广州市科能化妆品科研有限公司 | Oil-control acne-removing composition and application thereof in cosmetics |
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Application publication date: 20180629 |