CN108014023A - A kind of Pimple removing scream of the powder containing Khotan jade - Google Patents
A kind of Pimple removing scream of the powder containing Khotan jade Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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Abstract
The invention discloses a kind of Pimple removing scream of powder containing Khotan jade, this face cream is made of component：Nanoscale Khotan jade powder, Hericium erinaceus Polysaccharides, moisturizer, emollient, emulsifying agent, preservative, thickener, deionized water；Pimple removing scream of the present invention reaches anti-acne and without the effect of acne print using nanoscale Khotan jade powder antibacterial, the function of expression of suppression propionibacterium acnes and the effect cooperation hericium erinaceum polysaccharide promotion nerve growth factor to boost metabolism and the repair function of human body itself.
Description
Technical field
The present invention relates to cosmetic field, and in particular to a kind of Pimple removing scream of powder containing Khotan jade.
Background technology
Acne is being commonly called as acne, is called " whelk ", " dark sore " or " acne ", is due to hair follicle and sebum adenemphraxis, hair
A kind of skin disease that inflammation is triggered.During puberty, internal hormone can stimulate hair growth, promote smegma more heavy wool
Therefore fat, hair and sebaceous glands accumulate many materials, adhere to grease and bacterium, trigger the reaction of red swelling of the skin.Due to this
Symptom is common in youth of both sexes, so being known as " whelk ".Small pox break out when cause blood vessel dilatation, small pox disappear down after blood vessel simultaneously
It will not at once contract down, be formed some average red erythema, and the inflammatory response of Skin Cell is caused to skin group
The destruction knitted, the pigementation after inflammation can make the place for growing red small pox leave black dirty color, material is thus formed
Acne print.
The method of existing anti-acne has a many kinds, 1, such as laser therapy whelk method be to be contaminated by the high intensity of specific wavelength
Expect laser irradiation, energy rapid damage propionic acid whelk bacillus, effectively inhibits bacteria breeding, eliminate its stimulation and destruction to tissue
Effect, but the effect of laser therapy is too strong, and also simply physical method is destroyed funny, it is impossible to fundamentally anti-acne；2nd, it is sharp
It is existing with some natural plant component, Chinese medicinal ingredients or the Chinese medicines such as aloe, cucumber, lavender and plant mixing composition anti-acne
This anti-acne method safety, can play the role of adjusting skin oil and fat so as to fundamentally anti-acne, but often use this
Marking during kind natral plant ingredients anti-acne after time length, anti-acne is not easy to remove completely, and formula is to be improved；3rd, bigcatkin willow is utilized
Some Western medicine such as acid, Bo Nisong, dexamethasone remove acne, and the side effect of Western medicine is strong.
The content of the invention
It is an object of the invention to provide a kind of Pimple removing scream, this face cream suppresses acne third using nanoscale Khotan jade powder
The effect of acidfast bacilli reaches the effect of anti-acne, and coordinates human body in itself the effect of boost metabolism using nanoscale Khotan jade powder
Repair function repair the skin after anti-acne, reach the effect of no acne print；This face cream also added hericium erinaceum polysaccharide, have
Suppress the effect of TYR enzyme activity, achieve the purpose that whitening.
In order to achieve the above object, the present invention provides following technical solution：
A kind of Pimple removing scream of powder containing Khotan jade is made of following parts by weight ingredient：0.5-1 parts of nanoscale Khotan jade powder, monkey
0.5-2 parts of granulose of head, 10-25 parts of moisturizer, 5-10 parts of emollient, 3-7 parts of emulsifying agent, 0.1-0.2 parts of preservative, thickener
0.05-0.2 parts, 40-75 parts of deionized water.
Preferably, a kind of Pimple removing scream of powder containing Khotan jade is made of following parts by weight ingredient：Nanoscale Khotan jade powder 0.7
Part, 1 part of Hericium erinaceus Polysaccharides, 15 parts of moisturizer, 7 parts of emollient, 5 parts of emulsifying agent, 0.15 part of preservative, 0.1 part of thickener, go from
Sub- 55 parts of water, 0.7 part of Khotan jade powder, 1 part of Hericium erinaceus Polysaccharides.
The preparation method of the nanoscale Khotan jade powder includes the following steps：
(1) Khotan jade original powder is roughly ground using ball-milling technology, milling time 20min-3h；
(2) the powder screening that will be obtained after step (1) corase grinding is coarse powder and fine powder, wherein, the particle diameter of the coarse powder>2μ
M, the particle diameter of fine powder is≤2 μm；
(3) coarse powder in step (2) and fine powder are ground using ball-milling technology respectively, obtain particle diameter for 150~
The milling time of the fine powder of 200nm, wherein coarse powder is 2h, and the milling time of fine powder is 3h；
(4) fine powder that the particle diameter obtained in step (3) is 150~200nm is subjected to ultra-fine grind using ball-milling technology
Mill, obtains nanoscale Khotan jade powder, particle diameter≤100nm of the nanoscale Khotan jade powder at least one dimension.
The preparation method of the Hericium erinaceus Polysaccharides is：(1) Hericium erinaceus dry powder is taken, by 1:50 ratio adds distilled water and stirs
Mix uniformly, at 60 DEG C, ultrasonic extraction 60min under 130W, obtains extracting solution；(2) extracting solution that step (1) obtains is heated to 80
DEG C extracting at constant temperature 3h, then centrifuges 15min through 3000r/min, takes supernatant；(3) supernatant that step (2) obtains is heated to
80 DEG C of extracting at constant temperature 2.5h, then centrifuge 15min through 4000r/min, are concentrated by evaporation to a quarter of original volume, are concentrated
Liquid；(4) 95% ethanol of 4 times of volumes is added in the concentrate obtained to step (3), 8h is stood, filters to take precipitation；(5) will step
Suddenly the precipitation vacuum drying 2h that (4) obtain, temperature is 70 DEG C, obtains hericium erinaceum polysaccharide.
The moisturizer is：The mixture of any one or more in butanediol, propane diols, glycerine, Sodium Hyaluronate.
The emollient is：Caprylic/capric triglyceride, ring five dimethyl silicone polymer/cyclohexasiloxane, poly- diformazan
Radical siloxane, the cetostearyl alcohol mixture of any one or more.
The emulsifying agent is：Cetostearyl alcohol/cetearyl glucoside, polyacrylamide/C13-14 isoparaffins/
The mixture of laureth -7.
The preservative is Phenoxyethanol.
The present invention also provides a kind of Pimple removing scream of powder containing Khotan jade, comprise the following steps：
(1) emulsifying agent is put into oil phase pot as A phases with emollient mixing and is heated to 85 DEG C, stirring and dissolving is kept the temperature afterwards completely
It is stand-by；
(2) moisturizer, thickener and deionized water are mixed as B to be added in water phase pot and is heated to 85 DEG C, stirring is molten
The completely rear heat preservation for standby use of solution；
(3) emulsification pot is preheated to 60-65 DEG C, B phases, are first pumped into by 45 revs/min of mixing speed, then A phases are pumped into, and stir
Mix 30 minutes, temperature is maintained at 85 DEG C；Homogeneous 3 minutes；
(4) 40 DEG C are cooled to and adds D phases according to this, insulated and stirred 10 minutes, 35 revs/min of mixing speed, is eventually adding C
Phase, keeps the temperature 10-20 minutes；The C phases are preservative, and the D phases are nanoscale Khotan jade powder and hericium erinaceum polysaccharide；
(5) stirring is cooled to 40 DEG C and vacuumizes discharging.
Nanoscale Khotan jade powder：Contain sodium oxide molybdena, calcium oxide, aluminium oxide, iron oxide, potassium oxide, zinc oxide in Khotan jade,
With the effect for suppressing propionibacterium acnes；Also having in Khotan jade includes iron, copper, manganese, magnesium, cobalt, selenium, chromium, titanium, lithium, sodium etc.
Trace element, these trace elements promote blood circulation and metabolism, antibacterial, analgesic and the effect for promoting cytothesis.
The powder nanometer level Khotan jade powder diameter of particle≤100nm obtained by ball-milling technology of the present invention, far smaller than non-nano level and
Field jade powder, nanoscale Khotan jade powder than non-nano level Khotan jade powder more make full use of containing these components so that nanoscale
Khotan jade powder have preferably promote blood circulation and metabolism, antibacterial, analgesic and promote cytothesis effect.
Hericium erinaceum polysaccharide：Hericium erinaceum polysaccharide is most important active material in Hericium erinaceus, is commonly used for treating chronic gastritis
Gastric ulcer, has enhancing immunity of organisms, promotes the function of the expression of nerve growth factor.Found through experiment, hericium erinaceum polysaccharide
Also there is good oxidation resistance, the activity of TYR enzyme can be suppressed.
Beneficial effects of the present invention：
(1) Pimple removing scream of the present invention using nanoscale Khotan jade powder antibacterial, suppression propionibacterium acnes and promotes new old generation
The function of expression and the repair function of human body itself for the effect cooperation hericium erinaceum polysaccharide promotion nerve growth factor thanked, which reach, dispels
Acne and without the effect of acne print.
(2) activity that Pimple removing scream of the present invention can suppress TYR enzyme has good whitening effect.
Brief description of the drawings
Fig. 1：Inhibitory action of the Pimple removing scream to TYR enzyme activity.
Embodiment
Below in conjunction with specific embodiment, the present invention is further elaborated.
The embodiment of the present invention 1~3 and 1~2 Pimple removing scream formula of comparative example are shown in Table one
Table 1
The preparation method of above-described embodiment and the moisturizing face cream of comparative example is as follows：
(1) cetostearyl alcohol/cetearyl glucoside, polyacrylamide/C13-14 isoparaffins/laruyl alcohol are gathered
Ether -7 and caprylic/capric triglyceride, ring five dimethyl silicone polymer/cyclohexasiloxane, dimethyl silicone polymer, cetearyl alcohol
Alcohol mixing puts into oil phase pot as A phases and is heated to 85 DEG C, the completely rear heat preservation for standby use of stirring and dissolving；
(2) butanediol, propane diols, glycerine, Sodium Hyaluronate, carbomer and deionized water are mixed as B and is added to water
85 DEG C are heated in phase pot, the completely rear heat preservation for standby use of stirring and dissolving；
(3) emulsification pot is preheated to 60-65 DEG C, B phases, are first pumped into by 45 revs/min of mixing speed, then A phases are pumped into, and stir
Mix 30 minutes, temperature is maintained at 85 DEG C；Homogeneous 3 minutes；
(4) 40 DEG C are cooled to and adds D phases according to this, insulated and stirred 10 minutes, 35 revs/min of mixing speed, is eventually adding C
Phase, keeps the temperature 10-20 minutes；The C phases are Phenoxyethanol, and the D phases are nanoscale Khotan jade powder and hericium erinaceum polysaccharide；
(5) stirring is cooled to 40 DEG C and vacuumizes discharging.
The preparation method of the nanoscale Khotan jade powder includes the following steps：
(1) Khotan jade original powder is roughly ground using ball-milling technology, milling time 20min-3h；
(2) the powder screening that will be obtained after step (1) corase grinding is coarse powder and fine powder, wherein, the particle diameter of the coarse powder>2μ
M, the particle diameter of fine powder is≤2 μm；
(3) coarse powder in step (2) and fine powder are ground using ball-milling technology respectively, obtain particle diameter for 150~
The milling time of the fine powder of 200nm, wherein coarse powder is 2h, and the milling time of fine powder is 3h；
(4) fine powder that the particle diameter obtained in step (3) is 150~200nm is subjected to ultra-fine grind using ball-milling technology
Mill, obtains nanoscale Khotan jade powder, particle diameter≤100nm of the nanoscale Khotan jade powder at least one dimension.
The preparation method of the Hericium erinaceus Polysaccharides is：(1) Hericium erinaceus dry powder is taken, by 1:50 ratio adds distilled water and stirs
Mix uniformly, at 60 DEG C, ultrasonic extraction 60min under 130W, obtains extracting solution；(2) extracting solution that step (1) obtains is heated to 80
DEG C extracting at constant temperature 3h, then centrifuges 15min through 3000r/min, takes supernatant；(3) supernatant that step (2) obtains is heated to
80 DEG C of extracting at constant temperature 2.5h, then centrifuge 15min through 4000r/min, are concentrated by evaporation to a quarter of original volume, are concentrated
Liquid；(4) 95% ethanol of 4 times of volumes is added in the concentrate obtained to step (3), 8h is stood, filters to take precipitation；(5) will step
Suddenly the precipitation vacuum drying 2h that (4) obtain, temperature is 70 DEG C, obtains hericium erinaceum polysaccharide.
Suppression experiment to propionibacterium acnes
(1) test specimen：The Pimple removing scream of the preparation of embodiment 1~3, the Pimple removing scream of the preparation of comparative example 1~2, acne third
3 groups of acidfast bacilli bacterial strain (isolated at patients with acne skin lesion)；
(2) test method：
1. the culture of anaerobic bacteria, separation, identification：THl0 cultures will be inoculated at patients with acne skin lesion by isolated sample
In base, with airbag method, 37 DEG C of culture 72h in anaerobic jar are placed in, indicator are made with methylene blue, palladium grain pierces for catalysis.
2. the separation of anaerobic bacteria
Picking single bacterium colony, turns 2 pieces of tablets, one piece is placed in anaerobic jar, the lower 37 DEG C of pure cultures of anaerobic condition；Another piece with
37 DEG C of aerobic cultures；Result is observed after 48h.
3. the identification of anaerobic bacteria
Without bacterial growth under aerobic culture；
Occur homogeneous form, canescence, the circle of tiny, diameter about 1.0mm protrusions, edge on the tablet of Anaerobic culturel slightly
Neat bacterium colony, makees microscopy, visible chromabacterium biolaceum under mirror by bacterium colony.It is micro-bend in bar-shaped or rod-shaped, can one end blunt circle, one end attenuates,
Coloring is not deep, and cell is single, can arrange or arrange in pairs as the shape such as " people ", " v ".Tested again through oxytolerant, catalase test, indoles
Experiment, biochemical serial test for identification are propionibacterium acnes.
4. anaerobism drug sensitive test
Inoculation：1 colony inoculation in the bacterium colony more than picking cultivated is on LB plating mediums, 37 DEG C of aerobic trainings
24h is supported, aerobic culture 24h propionibacterium acneses are rinsed with sterile saline, flushing liquor is put into sterile test tube；Using wheat
Family name's turbidimetry is than turbid, and opacity tube is with shaking 12 times is before needed, first than turbid to 3 × 108/ mL, then with normal saline dilution to 106/ mL is standby
With.
LB plating mediums are inoculated with：The swab stick of sterilizing is dipped into bacterium solution, unnecessary bacterium solution is gone in being squeezed on tube wall, is trained in LB tablets
Even spread on base is supported, and a circle is swept along plate edge ring, covers plate, dry 2min.Sterile steel bowl (a diameter of 6mm) is light
It is put on plating medium, fills it up with the prevention acne composition of the gained of embodiment 1, be put into 37 DEG C of aerobic culture 24h, finds plate
Interior no bacterial growth, is shown in have inhibition zone to be formed after continuing 37 DEG C of aerobic culture 24h.Antibacterial circle diameter is surveyed, by 3 groups of antibacterial circle diameters
Value is averaged.
Result of the test：
Chinese medicine antibacterial susceptibility grade classification, with reference to corresponding antibiotic standard ".Inhibition zone diameter>20mm is Gao Min, 10~
20mm is quick in being,<10mm is drug resistance, and the results are shown in Table 2 for specific observation.
Table 2
The Pimple removing scream that can be seen that the preparation of embodiment 1~3 from the result of the test of table 2 is respectively provided with high quick effect (inhibition zone
Diameter>20mm), and comparative example 1~2 prepare Pimple removing scream only have in it is quick effect (10~20mm of antibacterial circle diameter).Explanation
Nanoscale Khotan jade powder and hericium erinaceum polysaccharide can be synergistic in the range of special ratios value of the present invention, have excellent antibacterial
Anti-inflammatory effect.
Pimple removing scream of the present invention suppresses the experiment of TYR enzyme enzyme
Method and apparatus
The made Pimple removing scream of embodiment 1；Ph=6.8 phosphate buffer solutions (PBS solution), sodium hydroxide (Chinese medicines group
Chemical reagent Co., Ltd)；TYR enzyme, Tyrosinase EC 1.14.18.19 (signa)；L-DOPA
(AcrosOrganics)；AB204-E electronic analytical balances (METTLE TOLEDO)；UV-1600 ultraviolet specrophotometers
(METTLE TOLEDO)。
During tyrosine changes into melanin, the catalytic action of TYR enzyme occurs mainly in TYR enzyme and is converted into
DOPA and DOPA change into the process of DOPA quinone, and DOPA quinone is a kind of coloring matter, has absorption at 475nm, using light splitting
Photometer measurement content.L-DOPA is substrate, measures the TYR enzyme inhibitory activity of Pimple removing scream of the present invention.
3 sample to be tested component of table
According to accurate absorption Pimple removing scream extracting solution of the present invention shown in table 3,0.15% DOPA solution, it is sufficiently mixed
It is even, the TYR enzyme solution for adding 300 μ/mL after ten minutes is incubated in 30 DEG C of water-baths, continues to cultivate ten minutes, exists immediately
475nm measures its light absorption value.
The calculation formula of TYR enzyme inhibiting rate (I) is as follows：
I=[(A-B)-(C-D)]/[A-B] × 100%
A:Not plus the absorbance A (A) surveyed of the enzyme mixed liquor of Pimple removing scream；
B:Not plus Pimple removing scream and not plus the absorbance A (B) surveyed of enzyme mixed liquor；
C：Add Pimple removing scream and enzyme absorbance A (C) mixed liquor, being surveyed；
D:The absorbance A (D) that the mixed liquor for adding Pimple removing scream not enzyme is surveyed.
Pimple removing scream sample is diluted to 40%, 50%, 60%, 70% respectively with PBS, the 80% each concentration of detection suppresses
TYR enzyme activity.The result is shown in Figure 1
Pimple removing scream concentration is when 40% to 80% as seen from Figure 1, Pimple removing scream suppress TYR enzyme activity with
The growth of metering and increase, when suppress TYR enzyme activity solubility reach 60% when, TYR enzyme inhibiting rate can reach 85%.
Claims (10)
1. the Pimple removing scream of a kind of powder containing Khotan jade, it is characterised in that the face cream is made of following parts by weight ingredient：Nanoscale
0.5-1 parts of Khotan jade powder, 0.5-2 parts of Hericium erinaceus Polysaccharides, 10-25 parts of moisturizer, 5-10 parts of emollient, 3-7 parts of emulsifying agent, anti-corrosion
0.1-0.2 parts of agent, 0.05-0.2 parts of thickener, 40-75 parts of deionized water.
2. the Pimple removing scream of the powder according to claim 1 containing Khotan jade, it is characterised in that the face cream is by following parts by weight
Component forms：It is 0.7 part of nanoscale Khotan jade powder, 1 part of Hericium erinaceus Polysaccharides, 15 parts of moisturizer, 7 parts of emollient, 5 parts of emulsifying agent, anti-
Rotten 0.15 part of agent, 0.1 part of thickener, 55 parts of deionized water, 0.7 part of Khotan jade powder, 1 part of Hericium erinaceus Polysaccharides.
3. the Pimple removing scream of the powder according to claim 1 or 2 containing Khotan jade, it is characterised in that the nanoscale and field
The preparation method of beautiful powder includes the following steps：
(1) Khotan jade original powder is roughly ground using ball-milling technology, milling time 20min-3h；
(2) the powder screening that will be obtained after step (1) corase grinding is coarse powder and fine powder, wherein, the particle diameter of the coarse powder>2 μm, carefully
The particle diameter of powder is≤2 μm；
(3) coarse powder in step (2) and fine powder are ground using ball-milling technology respectively, it is 150~200nm's to obtain particle diameter
The milling time of fine powder, wherein coarse powder is 2h, and the milling time of fine powder is 3h；
(4) fine powder that the particle diameter obtained in step (3) is 150~200nm is subjected to extra-fine grinding using ball-milling technology, obtained
To nanoscale Khotan jade powder, particle diameter≤100nm of the nanoscale Khotan jade powder at least one dimension.
4. the Pimple removing scream of the powder according to claim 1 or 2 containing Khotan jade, it is characterised in that the Hericium erinaceus Polysaccharides
Preparation method be：(1) Hericium erinaceus dry powder is taken, by 1:50 ratio adds distilled water and stirs evenly, ultrasonic under 130W at 60 DEG C
60min is extracted, obtains extracting solution；(2) extracting solution that step (1) obtains is heated to 80 DEG C of extracting at constant temperature 3h, Ran Houjing
3000r/min centrifuges 15min, takes supernatant；(3) supernatant that step (2) obtains is heated to 80 DEG C of extracting at constant temperature 2.5h, so
15min is centrifuged by 4000r/min, is concentrated by evaporation to a quarter of original volume, obtains concentrate；(4) obtained to step (3)
Concentrate in add 4 times of volumes 95% ethanol, stand 8h, filter to take precipitation；(5) the precipitation vacuum for obtaining step (4)
Dry 2h, temperature are 70 DEG C, obtain hericium erinaceum polysaccharide.
5. the Pimple removing scream of the powder according to claim 1 or 2 containing Khotan jade, it is characterised in that the moisturizer is:Fourth
The mixture of any one or more in glycol, propane diols, glycerine, Sodium Hyaluronate.
6. the Pimple removing scream of the powder according to claim 1 or 2 containing Khotan jade, it is characterised in that the emollient is：It is pungent
Acid/Triglyceride DDD, ring five dimethyl silicone polymer/cyclohexasiloxane, dimethyl silicone polymer, cetostearyl alcohol are any one
Kind or a variety of mixtures.
7. the Pimple removing scream of the powder according to claim 1 or 2 containing Khotan jade, it is characterised in that the emulsifying agent is：Whale
The mixture of wax stearyl alcohol/cetearyl glucoside, polyacrylamide/C13-14 isoparaffins/laureth -7.
8. the Pimple removing scream of the powder according to claim 1 or 2 containing Khotan jade, it is characterised in that the preservative is benzene
Oxyethanol.
9. the Pimple removing scream of the powder according to claim 1 or 2 containing Khotan jade, it is characterised in that the thickener is card
Ripple nurse.
10. a kind of method for preparing any one of the claim 1-9 Pimple removing screams, comprises the following steps：
(1) emulsifying agent is put into oil phase pot as A phases with emollient mixing and is heated to 85 DEG C, stirring and dissolving completely treat afterwards by insulation
With；
(2) moisturizer, thickener and deionized water are mixed to be added in water phase pot as B and is heated to 85 DEG C, stirring and dissolving is complete
Heat preservation for standby use after complete；
(3) emulsification pot is preheated to 60-65 DEG C, B phases, are first pumped into by 45 revs/min of mixing speed, then A phases are pumped into, stirring 30
Minute, temperature is maintained at 85 DEG C；Homogeneous 3 minutes；
(4) 40 DEG C are cooled to and adds D phases according to this, insulated and stirred 10 minutes, 35 revs/min of mixing speed, is eventually adding C phases, protects
It is 10-20 minutes warm；The C phases are preservative, and the D phases are nanoscale Khotan jade powder and hericium erinaceum polysaccharide；
(5) stirring is cooled to 40 DEG C and vacuumizes discharging.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108355046A (en) * | 2018-05-24 | 2018-08-03 | 广东山石微量元素研究院（普通合伙） | A kind of massage cream of the trace element containing Khotan jade and preparation method thereof |
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| CN108714154A (en) * | 2018-05-28 | 2018-10-30 | 广东山石微量元素研究院（普通合伙） | A kind of foot massage cream of the trace element containing Khotan jade and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108653125A (en) * | 2018-05-22 | 2018-10-16 | 广东山石微量元素研究院（普通合伙） | A kind of sunburn of trace element containing Khotan jade repairs the body film and preparation method thereof of whole body |
| CN108355046A (en) * | 2018-05-24 | 2018-08-03 | 广东山石微量元素研究院（普通合伙） | A kind of massage cream of the trace element containing Khotan jade and preparation method thereof |
| CN108392449A (en) * | 2018-05-24 | 2018-08-14 | 广东山石微量元素研究院（普通合伙） | A kind of Khotan jade anti-aging lotion and preparation method thereof |
| CN108714154A (en) * | 2018-05-28 | 2018-10-30 | 广东山石微量元素研究院（普通合伙） | A kind of foot massage cream of the trace element containing Khotan jade and preparation method thereof |
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