CN108371650A - Have effects that the composition of pox-eliminating whitening and pox-eliminating whitening skin care item - Google Patents
Have effects that the composition of pox-eliminating whitening and pox-eliminating whitening skin care item Download PDFInfo
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
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Abstract
Having effects that the composition of pox-eliminating whitening and pox-eliminating whitening skin care item the present invention relates to a kind of.It is above-mentioned to have effects that the composition of pox-eliminating whitening, it is equipped with the oyster shell extract centainly matched, leaflet marine algae extract, sea cucumber extract and water soluble pearl albumen, using the extract of marine organisms or the aqueous solution of marine organisms as main component, have effects that the composition of pox-eliminating whitening is more natural so that above-mentioned, avoids damage of the chemical substance to human body skin quality；And above-mentioned composition oyster shell extract and sea cucumber extract can play effect that is antibacterial and promoting to repair skin surface cell, so that above-mentioned composition has effects that anti-acne, and oyster shell extract and sea cucumber extract can promote water soluble pearl albumen and leaflet marine algae extract in the permeability of skin surface, the saponin component especially contained in sea cucumber extract, the hydrophily of water soluble pearl albumen can be increased so that the better white-skinned face function of water soluble pearl protein exhibits.
Description
Technical field
The present invention relates to daily chemical product technical field, more particularly to having effects that the composition of pox-eliminating whitening and anti-acne are beautiful
White skin care item.
Background technology
With stepping up for people's living standard, more and more people focus more on U.S. face skin care, and whelk is
Perplex the problem of people seeking beauty, whelk is that the infection allergy such as skin appearance redness, burning heat sensation, pain and maculopapule are anti-
It answers, it occur frequently that in the more position of sebaceous glands, when sebaceous glands is excessively flourishing, sebum secretion is excessively prosperous, pore is easily blocked up by grease
Plug is to form small pox.Small pox is difficult to remove after being formed, and is easy to form acne print in skin surface removal and then cause
Skin is obscure, lackluster.At present for easy long acne crowd, is developed and promoted there are many anti-acne skin-protection product, still
Currently used product for resolving poxes typically contains a large amount of salicylic acid and alcoholic content, and additional stimulation can be generated to skin；And mesh
Preceding anti-acne skin-protection product is difficult to play that alleviate skin obscure to reach whitening effect.
Invention content
Based on this, it is necessary to can generate stimulation to skin for current anti-acne skin-protection product and be difficult to have both alleviation skin
It is obscure to reach white-skinned face function the problem of, providing a kind of having effects that the composition of pox-eliminating whitening and pox-eliminating whitening skin care item.
It is a kind of to have effects that the composition of pox-eliminating whitening, include according to the mass fraction：6 parts~12 parts of oyster shell extraction
Object, 4 parts~8 parts of leaflet marine algae extract, 0.5 part~1 part of sea cucumber extract and 3 parts~6 parts of water soluble pearl albumen.
In a wherein embodiment, the oyster shell extract is prepared by the following method to obtain：
Oyster shell is crushed to obtain oyster shell powder；
The oyster shell powder is scattered in solvent and obtains dispersion liquid, the solvent in water, methanol and ethyl alcohol extremely
Few one kind；
It is centrifugally separating to obtain supernatant after carrying out refluxing extraction processing to the dispersion liquid；
The supernatant is evaporated under reduced pressure to obtain concentrate；
The concentrate is carried out using acetone lower layer's extract liquor is obtained by extraction；And
Concentration is carried out to lower layer's extract liquor to be evaporated to obtain the oyster shell extract.
In a wherein embodiment, further include before described the step of crushing the oyster shell to obtain oyster shell powder
Step：The oyster shell is impregnated in acid solution and carries out pickling, the acid solution is the salt that mass concentration is 0.5wt%~2wt%
Aqueous acid；And
The oyster shell through overpickling is eluted with water to neutrality.
In a wherein embodiment, the sea cucumber extract is prepared by the following method to obtain：
Sea cucumber meat is obtained by being cleaned after sea cucumber removing internal organ, is ground to obtain sea cucumber mill after water is added into sea cucumber meat
Slurry；
Homogenization is carried out to the sea cucumber defibrination；
Protease is added into the sea cucumber defibrination Jing Guo homogenization, and is ultrasonically treated；
Removing filter residue is filtered to the sea cucumber defibrination.
In a wherein embodiment, described be filtered after the step of removing filter residue to the sea cucumber defibrination is also wrapped
Include step：It obtains filtrate and the filtrate is carried out being concentrated into proportion being 1.1~1.3.
Further include 3 parts~8 parts of Chinese medical extract in a wherein embodiment.
In a wherein embodiment, the Chinese medical extract is Chinese medicine extract, prepares the Chinese medicine extract
Raw material includes by mass fraction：1 part~3 parts of saururus chinensis, 4 parts~6 parts of the rhizoma bolbostemmae, 1 part~3 parts of Prunella vulgaris, 1 part~3
The witch hazel, 0.5 part~1 part of rhodiola root, 3 parts~4 parts of coix seed, 1 part~2 parts of pueraria lobata and 1 part~2 parts of river of part
Rhizome of chuanxiong.
A kind of pox-eliminating whitening skin care item, including above-mentioned have effects that the composition of pox-eliminating whitening.
In a wherein embodiment, the dosage form of the pox-eliminating whitening skin care item is creme, lotion, aqua or facial mask.
In a wherein embodiment, the composition with pox-eliminating whitening is in the pox-eliminating whitening skin care item
In mass percentage be 0.6%~10%.
It is above-mentioned to have effects that the composition of pox-eliminating whitening and pox-eliminating whitening skin care item, it is equipped with the oyster shell extraction centainly matched
Object, leaflet marine algae extract, sea cucumber extract and water soluble pearl albumen, with the water-soluble of the extract of marine organisms or marine organisms
Liquid is as main component so that and it is above-mentioned to have effects that the composition of pox-eliminating whitening is more natural, chemical substance is avoided to human body
The damage of skin quality；And above-mentioned composition oyster shell extract and sea cucumber extract can play antibacterial and promote to repair skin surface
The effect of cell, so that above-mentioned composition has effects that anti-acne, and oyster shell extract and sea cucumber extract can promote
The soap contained in the permeability in skin surface, especially sea cucumber extract into water-soluble pearl protein and leaflet marine algae extract
Glucoside ingredient can increase the hydrophily of water soluble pearl albumen so that the better white-skinned face function of water soluble pearl protein exhibits.
Specific implementation mode
Below in conjunction with specific implementation mode to have effects that the composition of pox-eliminating whitening and pox-eliminating whitening skin care item do into
The detailed description of one step.
One embodiment has effects that the composition of pox-eliminating whitening includes 6 parts~12 parts of oyster according to the mass fraction
Shell extract, 4 parts~8 parts of leaflet marine algae extract, 0.5 part~1 part of sea cucumber extract, 3 parts~6 parts of water soluble pearl egg
The Chinese medical extract that 3 parts~8 parts of bletilla.
In a wherein embodiment, oyster shell extract can be powdered or liquid, and further, oyster shell carries
The dosage of object is taken to can also be 7 parts~10 parts, further, the dosage of oyster shell extract can also be 8 parts, 8.5 parts and 9
Part.
In a wherein embodiment, oyster shell extract is prepared by the following method：
(1) it will be eluted with water to obtain oyster shell after oyster fleshing；
(2) oyster shell is impregnated in acid solution and carries out pickling；
(3) oyster shell through overpickling is eluted with water to neutrality；
(4) oyster shell is crushed to obtain oyster shell powder；
(5) oyster shell powder is scattered in solvent and obtains dispersion liquid；
(6) supernatant is centrifugally separating to obtain after carrying out refluxing extraction processing to dispersion liquid；
(7) supernatant is evaporated under reduced pressure to obtain concentrate；
(8) concentrate is carried out lower layer's extract liquor is obtained by extraction using acetone；
(9) concentration is carried out to lower layer's extract liquor to be evaporated to obtain oyster shell extract.
It should be noted that in step (2), acid solution is the aqueous hydrochloric acid solution that mass concentration is 0.5wt%~2wt%.
Further, it is 1h~3h by the time of oyster shell dipping and progress pickling in acid solution.
In step (4), when crushing oyster shell to obtain oyster shell powder, the grain size of obtained oyster shell powder is 10 μm~50
μm。
In step (5), solvent is that solvent is selected from least one of water, methanol and ethyl alcohol.Further, solvent is selected from
The mixed solution of the mixed solution or water and ethyl alcohol of water and methanol.Further, when the mixed solution that solvent is water and methanol
When, the mass ratio of water and methanol is 1:1~1:4, when solvent is the mixed solution of water and ethyl alcohol, the mass ratio of water and methanol is
1:1~1:4.In a wherein embodiment, oyster shell is scattered in solvent by the way of ultrasonic disperse, ultrasound point
Scattered power is 300W~600W, and the time of ultrasonic disperse is 2h~3h.In a wherein embodiment, oyster shell powder with it is molten
The mass volume ratio of agent is 0.01g/mL~0.5g/mL.
In step (6), temperature when carrying out refluxing extraction processing to dispersion liquid is 75 DEG C~100 DEG C, further, into
The time of row refluxing extraction processing is 6h~12h.In a wherein embodiment, during carrying out refluxing extraction processing
The residual volume for observing solvent in real time is needed to add solvent into reaction system, when solvent residues are less to ensure oyster shell
The mass volume ratio of powder and solvent is 0.01g/mL~0.5g/mL.
In step (7), temperature when being evaporated under reduced pressure to supernatant is 45 DEG C~60 DEG C, further, is subtracted
The proportion for the concentrate that pressure distillation obtains stops vacuum distillation between being 1.2~1.5.
In step (8), when being extracted to concentrate using acetone, the volume ratio of acetone and concentrate is 1:1~3:
1, acetone and concentrate are extracted into 1h~2h after mixing.
It should be noted that in the present embodiment, oyster shell extract be it is powdered, it is in other embodiments, male
Oyster shell extract is liquid, can be omitted step (9) at this time.
The main component of oyster shell is the inorganic constituents such as calcium carbonate, and contains organic principle, such as protein, glycoprotein and more
Kind amino acid etc..Some researches show that calcium carbonate contained in oyster shell has the function of convergence analgesic, therefore can be by oyster shell
For in the treatment of gastric and duodenal ulcer, in addition, oyster shell may be utilized in sedative and inhibiting tumour cells agent.
In a wherein embodiment, according to the mass fraction, the dosage of leaflet marine algae extract can also be 5 parts~7
Part, further, the dosage of leaflet marine algae extract can also be 5.5 parts, 6 parts and 6.5 parts.An embodiment wherein
In, hydrolysis leaflet marine algae extract is prepared by following preparation methods：
(1) it is dispersed in water to obtain dispersion liquid after crushing leaflet seaweed；
(2) after dispersion liquid being heated to 45 DEG C~60 DEG C, be added cellulase into dispersion liquid, carry out enzyme digestion reaction 2h~
3h；
(3) dispersion liquid is heated to 95 DEG C~100 DEG C and obtains enzymolysis liquid；
(4) enzymolysis liquid is filtered to obtain filtrate, and concentrate is concentrated to give to filtrate；
(5) concentrate is dried to obtain leaflet marine algae extract dry powder.
It should be noted that in step (1), the mass ratio of leaflet seaweed and water is 1:3~1:4.It further, will be small
Leaf seaweed, which is dispersed in water, to be carried out by the way of homogenization, and homogenization carries out in refiner, and refiner turns
Speed is 800rpm~2000rpm, and the time of homogenization is 10min~20min.
In step (3), the proportion for carrying out being concentrated into concentrate to filtrate is 1.1~1.2.
In step (4), the when of obtaining leaflet marine algae extract dry powder is dried to concentrate, vacuum distillation may be used
Mode or the mode of spray drying carry out.It is understood that when required leaflet marine algae extract is liquid, step
(4) it can also omit.
Trehalose and protein for being rich in leaflet marine algae extract etc. can eliminate free radical, have oxidation resistant effect,
Prevent aging；And uricase activity can be inhibited, reduce the Ammonia substance of its generation, inhibit body odor；It can promote the decomposition of fat,
It can be used for diet products.In addition, leaflet marine algae extract can also inhibit the activity of brain amidase, it can improve and improve oiliness flesh
Skin.
In a wherein embodiment, according to the mass fraction, the dosage of water soluble pearl albumen can also be 4 parts, 4.7 parts
With 5 parts.
In a wherein embodiment, the preparation method of water-soluble pearl albumen is：Pearl is ground into pearl first
The grain size of powder, further pearl powder is 10nm~100nm；Pearl powder is dispersed in water again to obtain dispersion liquid, and at 40 DEG C
Homogenization processing is carried out at~60 DEG C, the time of processing is 30min~60min；By dispersion liquid be cooled to 5 DEG C~10 DEG C it is laggard
Row centrifuges and obtains supernatant liquor；Supernatant liquor is placed in bag filter again and carries out dialysis and carried out desalting processing in 3 days~5 days to obtain
To water-soluble pearl protein liquid；Water-soluble pearl protein liquid is dried and can be obtained water-soluble pearl protein powder.
Rich in there is the pearl composite whitening factor in water soluble pearl albumen, above-mentioned contain is added in the form of water soluble pearl albumen
When having in the composition for have effects that pox-eliminating whitening, preferable stability can be kept, to play whitening effect, in addition, on
State the permeability that composition system can promote water soluble pearl albumen in skin surface so that water soluble pearl protein exhibits are better
White-skinned face function.
In a wherein embodiment, according to the mass fraction, the dosage of sea cucumber extract can also be 0.7 part and 0.9
Part.
In a wherein embodiment, sea cucumber extract is prepared by the following method to obtain：
(1) by sea cucumber dipping, 85 DEG C~90 DEG C processing 30min~60min of 12h~be heated to afterwards for 24 hours are mixed in water
Object；
(2) homogenization is carried out to mixed liquor, the time of homogenization is 15min~30min；
(3) protease is added into mixed liquor to be digested to obtain enzymolysis liquid, the temperature of enzymolysis is 45 DEG C~60 DEG C, is carried out
The time of enzymolysis is 2h~3h；
(4) into enzymolysis liquid be added ethyl alcohol after, by enzymolysis liquid be placed at 75 DEG C~95 DEG C carry out refluxing extraction processing 4h~
8h；
(5) enzymolysis liquid is centrifugally separating to obtain supernatant, and concentrate is concentrated to give to supernatant；
(6) processing is dried to concentrate.
Sea cucumber has been proved to rich in natural collagen protein, polypeptide, sphingosine, saponin, mucopolysaccharide, the life of a variety of dimensions
The minerals such as amino acid and iron, phosphorus, manganese, selenium, iodine, calcium, magnesium, zinc that element, 18 kinds of human bodies need, amount to more than 50 kinds of nutrition at
Point, it is acknowledged as the natural nutrition invigorant beneficial to body.Sphingosine plays barrier, bonding, moisturizing, resists in skin
Aging, antiallergy, antibacterial etc. adapt to the effect of external environment；Saponin is very strong surfactant, can be spumed, molten except having
Outside the effect of blood, also immune, anti-inflammatory, antibacterial, antiallergy and oxidation resistant effect；Holothurian collagen, collagen are
The nutriment that human body anti-aging must supply, is present in each tissue of human body.Moreover, sea cucumber also has mystery
Power of regeneration, with sphingosine contained by sea cucumber etc., particular matters are related for this, it has cell adhesion together
Function.
In a wherein embodiment, according to the mass fraction, the dosage of Chinese medical extract can also be 4 parts, 5 parts, 6 parts
Or 7 parts.
It should be noted that in the present embodiment, Chinese medical extract is Chinese medicine extract, the original of Chinese medicine extract is prepared
Material include as mass fraction：1 part~3 parts of saururus chinensis, 4 parts~6 parts of the rhizoma bolbostemmae, 1 part~3 parts of Prunella vulgaris, 1 part~3
The witch hazel, 0.5 part~1 part of rhodiola root, 3 parts~4 parts of coix seed, 1 part~2 parts of pueraria lobata and 1 part~2 parts of river of part
Rhizome of chuanxiong.Further, Chinese medical extract includes according to the mass fraction：1.5 parts~2.5 parts of saururus chinensis, 5 parts~6 parts of the rhizoma bolbostemmae,
1 part~2 parts of Prunella vulgaris, 2 parts~2.5 parts of witch hazel, 0.5 part~0.8 part of rhodiola root, 3.5 parts~4 parts of coix seed, 1
Part~1.2 parts of pueraria lobata and 1 part~1.2 parts of Rhizoma Chuanxiong.Further, Chinese medical extract includes according to the mass fraction：The three of 2 parts
White grass, 5.5 parts of the rhizoma bolbostemmae, 1.5 parts of Prunella vulgaris, 2 parts of witch hazel, 0.8 part of rhodiola root, 4 parts of coix seed, 1.1 parts
Pueraria lobata and 1.1 parts of Rhizoma Chuanxiong.
The source of the rhizoma bolbostemmae is the dry tuber of the cucurbitaceous plant rhizoma bolbostemmae, and main component is Bolbostemma paniculatum glucoside A, glycosides second
With glycosides third, the rhizoma bolbostemmae and Prunella vulgaris, witch hazel and coix seed, which are equipped with certain proportioning and are used cooperatively, can inhibition chemical substance
To the stimulation of skin, allergy and inflammatory reaction, and have effects that heat-clearing, removing toxic substances and detumescence；Have to sensitive skin apparent
The effect of releiving, can moisten skin, improve blood circulation, promote skin-nourishing and oxygen supply；And have the effect of calmness, pacify,
It improves significantly effect to acne.
300 grass, rhodiola root and Rhizoma Chuanxiong, which are used cooperatively, has clearing heat and detoxicating effect, while melanin can be inhibited thin
The activity of the Proliferation, Differentiation and intracellular tyrosine enzyme of born of the same parents, hence it is evident that reduce the quantity of intracellular melanin；Skin can be promoted thin
Intracellular growth, the produced damaging action to skin histology of free radical for suppressing ultraviolet light and chemical substance to induce, makes skin elasticity
Increased collagen inhibits decomposition of collagen, maintains skin elasticity, inhibits tyrosine kinase activity；There is moisturizing and tender white simultaneously
Effect.
In addition, Chinese medical extract is added in above-mentioned composition, Chinese medical extract includes the saururus chinensis centainly matched, native shellfish
Mother, Prunella vulgaris, witch hazel, rhodiola root, coix seed, pueraria lobata and Rhizoma Chuanxiong so that mutual restraint between two drugs work can be generated between above-mentioned traditional Chinese medicinal components
With the Chinese medicine additive can not only strengthen the side effect that the function between these components avoids pharmacological property from mutually rushing, and inventor is trying
In testing it has also been found that, above-mentioned traditional Chinese medicine ingredients can not only effectively be absorbed by skin, and can comprehensive adjustment human body microenvironment, in turn
Promote absorption of the human body skin quality to oyster shell extract, leaflet marine algae extract, sea cucumber extract and water soluble pearl albumen so that
Above-mentioned the effect of having effects that the composition of pox-eliminating whitening, is more obvious.
Further, the method for preparing above-mentioned Chinese medicine extract is：By mass fraction by above-mentioned traditional Chinese medicinal components co-grinding
Obtain mixture；Mixture is put into the cellulase solution that mass concentration is 0.1%~0.5% again and carries out enzymolysis 1h~2h
Obtain dispersion liquid；Adjust again dispersion liquid pH value be 4.5~5.5 between, using centrifugation method to dispersion liquid carry out from
The heart, separation removal lower sediment obtain Chinese medicine extract.It should be noted that in above-mentioned Chinese medicine extract, each traditional Chinese medicinal components
The mass ratio of gross mass and cellulase solution is 1:1~1:2.
It is above-mentioned to have effects that the composition of pox-eliminating whitening, it is equipped with the oyster shell extract centainly matched, the extraction of leaflet seaweed
Object, sea cucumber extract and water soluble pearl albumen, using the extract of marine organisms or the aqueous solution of marine organisms as main component,
Have effects that the composition of pox-eliminating whitening is more natural so that above-mentioned, avoids damage of the chemical substance to human body skin quality；On and
Effect that is antibacterial and promoting to repair skin surface cell can be played by stating composition oyster shell extract and sea cucumber extract, to
So that above-mentioned composition has effects that anti-acne, and oyster shell extract and sea cucumber extract can promote water soluble pearl albumen with
The saponin component that leaflet marine algae extract contains in the permeability in skin surface, especially sea cucumber extract can increase
The hydrophily of water soluble pearl albumen so that the better white-skinned face function of water soluble pearl protein exhibits.
It should be noted that since the saponin in sea cucumber extract is very strong surfactant in above-mentioned composition, and
The stability of water soluble pearl albumen is inadequate, and sea cucumber extract and water soluble pearl albumen are used in compounding, and can improve water soluble pearl
Albumen is in the above-mentioned stability with the composition of pox-eliminating whitening.
A kind of pox-eliminating whitening skin care item, including above-mentioned have effects that the composition of pox-eliminating whitening.
Further, the dosage form of above-mentioned pox-eliminating whitening skin care item is creme, lotion, aqua or facial mask.
Further, have effects that the mass percentage of the composition of pox-eliminating whitening is in above-mentioned pox-eliminating whitening skin care item
0.6wt%~10wt%.
A kind of pox-eliminating whitening shin moisturizer, including shin moisturizer matrix and above-mentioned have effects that the composition of pox-eliminating whitening, wherein
Have effects that the mass percentage of the composition of pox-eliminating whitening is 1wt%~5wt%.
In a wherein embodiment, above-mentioned shin moisturizer matrix includes according to the mass fraction：3 parts of isopropyl palmitate
~8 parts, 0.2 part~0.6 part of tocopherol acetate, 6 parts~12 parts of butanediol, 6 parts~12 parts of glycerine, PEG-60 rilanit specials
0.2 part~0.4 part and 75 parts~90 parts of water.
A kind of pox-eliminating whitening skin care milk, including skin care milk matrix and above-mentioned have effects that the composition of pox-eliminating whitening, wherein
Have effects that the mass percentage of the composition of pox-eliminating whitening is 4wt%~10wt%.
In a wherein embodiment, above-mentioned skin care milk matrix includes according to the mass fraction：Evening primrose oil 5 parts~8
Part, 3 parts~6 parts of ethylhexyl palmitate, 1 part~5 parts of cetanol ethylhexoate, 1 part~5 parts of emulsifier, glycerine 6 parts~10
50 parts~65 parts of part and water.
A kind of anti-aging whitening mask, including mask matrix and above-mentioned have effects that the composition of pox-eliminating whitening, wherein tool
It is 1wt%~3wt% to have the mass percentage of the composition of pox-eliminating whitening effect.
In a wherein embodiment, above-mentioned mask matrix includes according to the mass fraction：Isopropyl palmitate 3 parts~8
Part, 0.2 part~0.6 part of tocopherol acetate, 6 parts~12 parts of butanediol, 6 parts~12 parts of glycerine, PEG-60 rilanit specials 0.2
Part~0.4 part and 75 parts~90 parts of water.
It is the explanation of specific embodiment below, following embodiment unless otherwise specified, is not then contained except inevitably miscellaneous
The component pointed out is not known in other other than matter.
Embodiment 1
Present embodiment has effects that the composition of pox-eliminating whitening, includes 7 parts of oyster shell extraction according to the mass fraction
Object, 7 parts of leaflet marine algae extract, 1 part of sea cucumber extract, 5 parts of water soluble pearl albumen and 8 parts of Chinese medical extract.
Wherein, Chinese medical extract is Chinese medicine extract, the gross mass of each traditional Chinese medicinal components and the mass ratio of cellulase solution
It is 1:1, and the raw material for preparing Chinese medicine extract includes as mass fraction：1 part of saururus chinensis, 6 parts of the rhizoma bolbostemmae, 3 parts of summer
Withered grass, 1 part of witch hazel, 0.5 part of rhodiola root, 3 parts of coix seed, 2 parts of pueraria lobata and 2 parts of Rhizoma Chuanxiong.
Embodiment 2
Present embodiment has effects that the composition of pox-eliminating whitening, includes 9 parts of oyster shell extraction according to the mass fraction
Object, 6.5 parts of leaflet marine algae extract, 0.9 part of sea cucumber extract, 4 parts of water soluble pearl albumen and 4 parts of traditional Chinese medicine extraction
Object.
Wherein, Chinese medical extract is Chinese medicine extract, the gross mass of each traditional Chinese medicinal components and the mass ratio of cellulase solution
It is 1:1, and the raw material for preparing Chinese medicine extract includes as mass fraction：1.5 parts of saururus chinensis, 6 parts of the rhizoma bolbostemmae, 2 parts
Prunella vulgaris, 2.5 parts of witch hazel, 0.5 part of rhodiola root, 4 parts of coix seed, 1 part of pueraria lobata and 1.2 parts of Rhizoma Chuanxiong.
Embodiment 3
Present embodiment has effects that the composition of pox-eliminating whitening, is carried according to the mass fraction including 8.5 parts of oyster shell
Take object, 5.5 parts of leaflet marine algae extract, 1 part of sea cucumber extract, 4.7 parts of water soluble pearl albumen and 7 parts of traditional Chinese medicine extraction
Object.
Wherein, Chinese medical extract is Chinese medicine extract, the gross mass of each traditional Chinese medicinal components and the mass ratio of cellulase solution
It is 1:1, and the raw material for preparing Chinese medicine extract includes as mass fraction：2 parts of saururus chinensis, 5.5 parts of the rhizoma bolbostemmae, 1.5 parts
Prunella vulgaris, 2 parts of witch hazel, 0.8 part of rhodiola root, 4 parts of coix seed, 1.1 parts of pueraria lobata and 1.1 parts of Rhizoma Chuanxiong.
Embodiment 4
Present embodiment has effects that the composition of pox-eliminating whitening, includes 8 parts of oyster shell extraction according to the mass fraction
Object, 6 parts of leaflet marine algae extract, 0.7 part of sea cucumber extract, 4 parts of water soluble pearl albumen and 5 parts of Chinese medical extract.
Wherein, Chinese medical extract is Chinese medicine extract, the gross mass of each traditional Chinese medicinal components and the mass ratio of cellulase solution
It is 1:1, and the raw material for preparing Chinese medicine extract includes as mass fraction：2.5 parts of saururus chinensis, 5 parts of the rhizoma bolbostemmae, 1 part
Prunella vulgaris, 2 parts of witch hazel, 0.8 part of rhodiola root, 3.5 parts of coix seed, 1.2 parts of pueraria lobata and 1 part of Rhizoma Chuanxiong.
Embodiment 5
Present embodiment has effects that the composition of pox-eliminating whitening, includes 10 parts of oyster shell extraction according to the mass fraction
Object, 5 parts of leaflet marine algae extract, 0.5 part of sea cucumber extract, 4.7 parts of water soluble pearl albumen and 3 parts of traditional Chinese medicine extraction
Object.
Wherein, Chinese medical extract is Chinese medicine extract, the gross mass of each traditional Chinese medicinal components and the mass ratio of cellulase solution
It is 1:1, and the raw material for preparing Chinese medicine extract includes as mass fraction：3 parts of saururus chinensis, 4 parts of the rhizoma bolbostemmae, 1 part of summer
Withered grass, 3 parts of witch hazel, 1 part of rhodiola root, 4 parts of coix seed, 1 part of pueraria lobata and 1 part of Rhizoma Chuanxiong.
Embodiment 6
Present embodiment has effects that the composition of pox-eliminating whitening, is carried according to the mass fraction including 9.5 parts of oyster shell
Take object, 5.5 parts of leaflet marine algae extract, 4.7 parts of water soluble pearl albumen and 7 parts of Chinese medical extract.
Wherein, Chinese medical extract is Chinese medicine extract, the gross mass of each traditional Chinese medicinal components and the mass ratio of cellulase solution
It is 1:1, and the raw material for preparing Chinese medicine extract includes as mass fraction：2 parts of saururus chinensis, 5.5 parts of the rhizoma bolbostemmae, 1.5 parts
Prunella vulgaris, 2 parts of witch hazel, 0.8 part of rhodiola root, 4 parts of coix seed, 1.1 parts of pueraria lobata and 1.1 parts of Rhizoma Chuanxiong.
Embodiment 7
Present embodiment has effects that the composition of pox-eliminating whitening, is carried according to the mass fraction including 8.5 parts of oyster meat
Take object, 5.5 parts of leaflet marine algae extract, 1 part of sea cucumber extract, 4.7 parts of water soluble pearl albumen and 7 parts of traditional Chinese medicine extraction
Object.
Wherein, Chinese medical extract is Chinese medicine extract, the gross mass of each traditional Chinese medicinal components and the mass ratio of cellulase solution
It is 1:2, and the raw material for preparing Chinese medicine extract includes as mass fraction：2 parts of saururus chinensis, 5.5 parts of the rhizoma bolbostemmae, 1.5 parts
Prunella vulgaris, 2 parts of witch hazel, 0.8 part of rhodiola root, 4 parts of coix seed, 1.1 parts of pueraria lobata and 1.1 parts of Rhizoma Chuanxiong.
Embodiment 8
Present embodiment has effects that the composition of pox-eliminating whitening, is carried according to the mass fraction including 8.5 parts of oyster shell
Take object, 5.5 parts of leaflet marine algae extract, 1 part of sea cucumber extract and 4.7 parts of water soluble pearl albumen.
Embodiment 9
Present embodiment has effects that the composition of pox-eliminating whitening, is carried according to the mass fraction including 8.5 parts of oyster shell
Take object, 5.5 parts of leaflet marine algae extract, 1 part of salicylic acid and 4.7 parts of water soluble pearl albumen.
Embodiment 10
Present embodiment has effects that the composition of pox-eliminating whitening, is carried according to the mass fraction including 8.5 parts of oyster meat
Take object, 5.5 parts of leaflet marine algae extract, 1 part of sea cucumber extract and 4.7 parts of water soluble pearl albumen.
One, stability test
Take 100g Examples 1 to 10 respectively has effects that the composition of pox-eliminating whitening, in sealed states, is positioned over 25
DEG C insulating box in preserve, store 360 days, record the above-mentioned steadiness with the composition of pox-eliminating whitening, as a result
As shown in table 1.It refers to composition under above-mentioned condition of storage wherein to have good stability, and layering, discoloration, cohesion does not occur or becomes
Phenomena such as matter.
Table 1
| Stability | |
| Embodiment 1 | Well |
| Embodiment 2 | Well |
| Embodiment 3 | Well |
| Embodiment 4 | Well |
| Embodiment 5 | Well |
| Embodiment 6 | The phenomenon that storage is turned to be yellow after 185 days |
| Embodiment 7 | Well |
| Embodiment 8 | Well |
| Embodiment 9 | The phenomenon that storage is turned to be yellow after 120 days |
| Embodiment 10 | Well |
As can be seen from the above experimental data, sea cucumber extract is added in the above-mentioned composition with pox-eliminating whitening
Stable effect can be played to water-soluble pearl albumen, so that above-mentioned composition has preferable storage stability.
Two, the Inhibition test of propionibacterium acnes
Test method：(1) obtain Examples 1 to 10 has effects that the composition of pox-eliminating whitening；
(2) 10 plants of propionibacterium acnes isolated from whelk patient skin：
A) by strict sterilization at patients with acne skin lesion, aseptic syringe needle punctures skin at skin lesion, is squeezed with the acne needles after sterilizing
Acne content is extruded, is inoculated in Bu Shi culture plates using disposable ring sectional streak, it, will after inoculation using airbag method
Tablet, which is immediately placed in anaerobic gas generation bag to be placed in 35 DEG C of constant temperature CO2 incubators, cultivates 48h, is inoculated with while taking part acne content
Object smear, microscopy after Gram's staining.
B) while turning two tablets, a continuation Anaerobic culturel, another aerobic culture observes result after 48 hours.
C) under aerobic condition, bacterium takes out the tablet through Anaerobic culturel 48h, picks out single canescence, circle without growth
Opaque tiny bacterium colony, microscopy after Gram's staining are shown in bacterium under mirror in rodlike, and straight or micro-bend, arrangement is in X, Y, V and grid
Shape；It is again propionibacterium acnes through oxytolerant experiment, catalase test, indoles experiment, biochemical serial experimental identification.
D) inoculation：1 colony inoculation in the bacterium colony of above-mentioned culture is selected on LB plating mediums, 37 DEG C aerobic
For 24 hours, by aerobic culture, propionibacterium acnes are rinsed with sterile saline for 24 hours, and flushing liquor is put into sterile test tube, are used for culture
Maxwell turbidimetry is than turbid, first than turbid to 3 × 108/mL, then with normal saline dilution to 106/mL.
LB culture medium inoculateds：The cotton balls of sterilizing is dipped into bacterium solution, the even spread on LB tablets, and swept along plate edge ring
One encloses, and plate after lid is dry, and sterile steel bowl is put down gently on plating medium.
(3) Examples 1 to 10 is added on 10 above-mentioned plating mediums respectively has effects that the combination of pox-eliminating whitening
Object is put into 37 DEG C of aerobic cultures and sees have inhibition zone to be formed for 24 hours, surveys the diameter of inhibition zone, the results are shown in Table 2.According to corresponding anti-
Raw element standard, Chinese medicine antibacterial susceptibility grade classification, antibacterial circle diameter>20mm is Gao Min, 10~20 be in it is quick,<10mm is resistance to
Medicine.
Table 2
| Antibacterial circle diameter (mm) | |
| Embodiment 1 | 20.3 |
| Embodiment 2 | 21.7 |
| Embodiment 3 | 23.8 |
| Embodiment 4 | 22.1 |
| Embodiment 5 | 20.8 |
| Embodiment 6 | 16.7 |
| Embodiment 7 | 17.8 |
| Embodiment 8 | 15.4 |
| Embodiment 9 | 11.2 |
| Embodiment 10 | 12.8 |
Three, the active inhibition experiment of TYR enzyme
The composition with pox-eliminating whitening of Examples 1 to 10 surveys the active inhibiting rate of TYR enzyme
Examination, the results are shown in Table 3.
Wherein, test philosophy is：In the forming process of melanin, TYR enzyme plays the role of critical, fat
Sour tyrosine generates DOPA quinone under the action of TYR enzyme, and DOPA quinone is under the oxidation of enzyme or non-enzymatic, by red
Plain or colourless pigment is transformed into melanin, this process is the key step that melanin generates, and therefore, hinders or inhibit network ammonia
The activity of sour enzyme can inhibit the generation of melanin in the first stage.Based on this, if having can inhibit TYR enzyme active
Ability is to evaluate one of the important indicator of Skin whitening care cosmetics.
Test method：The composition of Examples 1 to 10 is diluted to by mass body using the phosphate buffer of pH=6.8 respectively
It is for use by taking supernatant to obtain sample solution after ultrasonic wave auxiliary dissolving 1h after accumulating than 1%.
The tyrosine and 1ml pH=6.8 that the molar concentration of the above-mentioned sample solution, 1mL that take 0.9mL respectively is 0.3M
Phosphate buffer is uniformly mixed to be placed in 37 DEG C of thermostatic water baths and preheat 10 minutes, adds 0.1ml tyrosinase aqueous solutions
(1.0mg/ml, mcllvains buffer solution), is sufficiently stirred, and absorbance is measured under 475nm wavelength after being reacted 15 minutes at 37 DEG C
For Di；
The phosphate buffer for the tyrosine and 1.9ml pH=6.8 that the molar concentration of 1mL is 0.3M is taken to be uniformly mixed postposition
It is preheated 10 minutes in 37 DEG C of thermostatic water baths, adding 0.1ml tyrosinases aqueous solution, (1.0mg/ml, mcllvains are buffered
Liquid), it is sufficiently stirred, it is Ei to measure absorbance under 475nm wavelength after being reacted 15 minutes at 37 DEG C；
It takes the phosphate buffer for the tyrosine and 2ml pH=6.8 that the molar concentration of 1mL is 0.3M to be uniformly mixed to be placed on
Preheat 25 minutes, be sufficiently stirred in 37 DEG C of thermostatic water baths, after under 475nm wavelength measure absorbance be Fi；
Absorbance test is carried out using UV-1600 ultraviolet specrophotometers, wherein the calculation formula of inhibiting rate is：Mi%-
=(Ei-Di)/(Ei-Fi) × 100%.
Table 3
Have effects that the composition of pox-eliminating whitening is used to prepare to obtain pox-eliminating whitening shield by what Examples 1 to 10 was prepared
Skin liquid, wherein pox-eliminating whitening shin moisturizer includes shin moisturizer matrix and above-mentioned has effects that the composition of pox-eliminating whitening, said combination
Mass percentage of the object in pox-eliminating whitening shin moisturizer is as shown in table 4.Wherein, shin moisturizer matrix includes according to the mass fraction：
6 parts of isopropyl palmitate, 0.6 part of tocopherol acetate, 10 parts of butanediol, 8 parts of glycerine, 0.4 part of PEG-60 rilanit specials and
80 parts of water.
The anti-acne and whitening effect of above-mentioned pox-eliminating whitening shin moisturizer are tested, the results are shown in Table 4.
When being tested, the female test person that 200 ages are 25~28 years old is chosen, is randomly divided into 10 groups, every group of 20 people.
Skin care processing, usage time are carried out using the pox-eliminating whitening shin moisturizer for using the present embodiment to be prepared after same face cleaning product
It is 60 days, experimenter's every morning and the pox-eliminating whitening shin moisturizer progress skin care for using the present embodiment respectively at night, application method
Specially：It takes pox-eliminating whitening shin moisturizer 2mL to be uniformly applied to skin of face, smears 5 minutes.It should be noted that above-mentioned experiment
Other skin nursing situations of person are consistent.
(1) anti-acne effect is tested：Test object is following three kinds of skin types：Skin is dark yellow, pigment deposition is more apparent；Skin
Skin has small pox or acne, acne print apparent throughout the year；Local skin allergy has red and swollen or pimple.
Evaluation criterion is：It is effective：The colour of skin obviously bleaches, acne print disappears；Effectively：Skin obviously bleaches, acne print is desalinated；Nothing
Effect：The colour of skin is without significant change, small pox and acne print without significant change.
(2) whitening effect is tested：Pox-eliminating whitening shin moisturizer is stated using MEXAMETER MX18 skin pigments instrument in use
The previous day and tested using the dermal melanin content after above-mentioned pox-eliminating whitening shin moisturizer 60 days, test condition is：It surveys
It is 25 DEG C to try temperature, ambient humidity 50%.
The calculation formula of melanin reduced rate is：Pi%=(Li-Ni)/Li × 100%, wherein Li is using anti-acne U.S.
The melanin content of white shin moisturizer the previous day, Ni are using the dermal melanin content after pox-eliminating whitening shin moisturizer 60 days.Every group
Test obtained melanin reduced rate remove two highests and two it is minimum after be averaged.
Table 4
Each technical characteristic of embodiment described above can be combined arbitrarily, to keep description succinct, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, it is all considered to be the range of this specification record.
Several embodiments of the invention above described embodiment only expresses, the description thereof is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art
It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the protection of the present invention
Range.Therefore, the protection domain of patent of the present invention should be determined by the appended claims.
Claims (10)
1. a kind of having effects that the composition of pox-eliminating whitening, which is characterized in that include according to the mass fraction：6 parts~12 parts male
Oyster shell extract, 4 parts~8 parts of leaflet marine algae extract, 0.5 part~1 part of sea cucumber extract and 3 parts~6 parts of water-soluble treasure
Globin.
2. according to claim 1 have effects that the composition of pox-eliminating whitening, which is characterized in that the oyster shell extract
It is prepared by the following method to obtain：
Oyster shell is crushed to obtain oyster shell powder；
The oyster shell powder is scattered in solvent and obtains dispersion liquid, the solvent in water, methanol and ethyl alcohol at least one
Kind；
It is centrifugally separating to obtain supernatant after carrying out refluxing extraction processing to the dispersion liquid；
The supernatant is evaporated under reduced pressure to obtain concentrate；
The concentrate is carried out using acetone lower layer's extract liquor is obtained by extraction；And
Concentration is carried out to lower layer's extract liquor to be evaporated to obtain the oyster shell extract.
3. according to claim 2 have effects that the composition of pox-eliminating whitening, which is characterized in that described by the oyster shell
Crushing further includes step before obtaining the step of oyster shell powder：The oyster shell is impregnated in acid solution and carries out pickling, the acid
Liquid is the aqueous hydrochloric acid solution that mass concentration is 0.5wt%~2wt%；And
The oyster shell through overpickling is eluted with water to neutrality.
4. according to claim 1 have effects that the composition of pox-eliminating whitening, which is characterized in that the sea cucumber extract is logical
Following methods are crossed to be prepared：
Sea cucumber meat is obtained by being cleaned after sea cucumber removing internal organ, is ground to obtain sea cucumber defibrination after water is added into sea cucumber meat；
Homogenization is carried out to the sea cucumber defibrination；
Protease is added into the sea cucumber defibrination Jing Guo homogenization, and is ultrasonically treated；
Removing filter residue is filtered to the sea cucumber defibrination.
5. according to claim 4 have effects that the composition of pox-eliminating whitening, which is characterized in that described to be ground to the sea cucumber
Slurry further includes step after being filtered the step of removing filter residue：Obtain filtrate and the filtrate is carried out being concentrated into proportion be
1.1~1.3.
6. according to claim 1 have effects that the composition of pox-eliminating whitening, which is characterized in that further include 3 parts~8 parts
Chinese medical extract.
7. according to claim 6 have effects that the composition of pox-eliminating whitening, which is characterized in that the Chinese medical extract is
Chinese medicine extract, the raw material for preparing the Chinese medicine extract include by mass fraction：1 part~3 parts of saururus chinensis, 4 parts~6 parts
The rhizoma bolbostemmae, 1 part~3 parts of Prunella vulgaris, 1 part~3 parts of witch hazel, 0.5 part~1 part of rhodiola root, 3 parts~4 parts of coix seed,
1 part~2 parts of pueraria lobata and 1 part~2 parts of Rhizoma Chuanxiong.
8. a kind of pox-eliminating whitening skin care item, which is characterized in that have anti-acne beautiful including such as claim 1~7 any one of them
The composition of contour painting effect.
9. pox-eliminating whitening skin care item according to claim 8, which is characterized in that the dosage form of the pox-eliminating whitening skin care item is
Creme, lotion, aqua or facial mask.
10. pox-eliminating whitening skin care item according to claim 8, which is characterized in that described to have effects that the group of pox-eliminating whitening
It is 0.6%~10% to close mass percentage of the object in the pox-eliminating whitening skin care item.
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| CN201810290045.5A CN108371650A (en) | 2018-04-03 | 2018-04-03 | Have effects that the composition of pox-eliminating whitening and pox-eliminating whitening skin care item |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810290045.5A CN108371650A (en) | 2018-04-03 | 2018-04-03 | Have effects that the composition of pox-eliminating whitening and pox-eliminating whitening skin care item |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108904425A (en) * | 2018-08-23 | 2018-11-30 | 广州乐草元生物科技有限公司 | A kind of pox-removing face mask |
| CN112121223A (en) * | 2020-10-16 | 2020-12-25 | 河南民兴生物科技股份有限公司 | Sericin medical dressing and production method thereof |
| CN118059013A (en) * | 2024-04-17 | 2024-05-24 | 江苏亨瑞生物医药科技有限公司 | Moisturizing and water-locking body lotion containing collagen and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101953850A (en) * | 2010-09-08 | 2011-01-26 | 中国海洋大学 | Preparation method and application of oyster shell extract |
| CN102178636A (en) * | 2011-04-27 | 2011-09-14 | 中国科学院南海海洋研究所 | Marine biological function cosmetic for minimizing pores |
| CN106619446A (en) * | 2016-12-06 | 2017-05-10 | 四川自然菲科技有限公司 | Composition capable of expelling toxin and beautifying skin, skin-care lotion capable of expelling toxin and beautifying skin and preparation method thereof |
-
2018
- 2018-04-03 CN CN201810290045.5A patent/CN108371650A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101953850A (en) * | 2010-09-08 | 2011-01-26 | 中国海洋大学 | Preparation method and application of oyster shell extract |
| CN102178636A (en) * | 2011-04-27 | 2011-09-14 | 中国科学院南海海洋研究所 | Marine biological function cosmetic for minimizing pores |
| CN106619446A (en) * | 2016-12-06 | 2017-05-10 | 四川自然菲科技有限公司 | Composition capable of expelling toxin and beautifying skin, skin-care lotion capable of expelling toxin and beautifying skin and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108904425A (en) * | 2018-08-23 | 2018-11-30 | 广州乐草元生物科技有限公司 | A kind of pox-removing face mask |
| CN112121223A (en) * | 2020-10-16 | 2020-12-25 | 河南民兴生物科技股份有限公司 | Sericin medical dressing and production method thereof |
| CN118059013A (en) * | 2024-04-17 | 2024-05-24 | 江苏亨瑞生物医药科技有限公司 | Moisturizing and water-locking body lotion containing collagen and preparation method thereof |
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Application publication date: 20180807 |