CN110755331A - Antibacterial infant washing and caring preparation and application thereof - Google Patents
Antibacterial infant washing and caring preparation and application thereof Download PDFInfo
- Publication number
- CN110755331A CN110755331A CN201911221080.2A CN201911221080A CN110755331A CN 110755331 A CN110755331 A CN 110755331A CN 201911221080 A CN201911221080 A CN 201911221080A CN 110755331 A CN110755331 A CN 110755331A
- Authority
- CN
- China
- Prior art keywords
- extract
- antibacterial
- parts
- infant
- sodium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 65
- 238000002360 preparation method Methods 0.000 title claims abstract description 39
- 238000005406 washing Methods 0.000 title description 15
- 239000000284 extract Substances 0.000 claims abstract description 98
- 239000002994 raw material Substances 0.000 claims abstract description 25
- 241000628997 Flos Species 0.000 claims abstract description 11
- 239000006210 lotion Substances 0.000 claims abstract description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 93
- 239000002904 solvent Substances 0.000 claims description 49
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 40
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 39
- 235000011187 glycerol Nutrition 0.000 claims description 34
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid group Chemical group C(CC(O)(C(=O)O)CC(=O)O)(=O)O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 33
- 239000000203 mixture Substances 0.000 claims description 26
- 239000003906 humectant Substances 0.000 claims description 25
- 239000004094 surface-active agent Substances 0.000 claims description 24
- 241000205585 Aquilegia canadensis Species 0.000 claims description 22
- 240000006688 Telosma cordata Species 0.000 claims description 20
- 235000017352 Telosma cordata Nutrition 0.000 claims description 20
- 239000002453 shampoo Substances 0.000 claims description 19
- 235000005979 Citrus limon Nutrition 0.000 claims description 17
- 244000131522 Citrus pyriformis Species 0.000 claims description 17
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims description 17
- 239000004359 castor oil Substances 0.000 claims description 17
- 235000019438 castor oil Nutrition 0.000 claims description 17
- 239000003974 emollient agent Substances 0.000 claims description 17
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 17
- 229940101267 panthenol Drugs 0.000 claims description 17
- 239000011619 pantothenol Substances 0.000 claims description 17
- 235000020957 pantothenol Nutrition 0.000 claims description 17
- 239000002738 chelating agent Substances 0.000 claims description 16
- 239000003921 oil Substances 0.000 claims description 16
- 108010013296 Sericins Proteins 0.000 claims description 13
- AEIJTFQOBWATKX-UHFFFAOYSA-N octane-1,2-diol Chemical compound CCCCCCC(O)CO AEIJTFQOBWATKX-UHFFFAOYSA-N 0.000 claims description 11
- 229940045944 sodium lauroyl glutamate Drugs 0.000 claims description 10
- IWIUXJGIDSGWDN-UQKRIMTDSA-M sodium;(2s)-2-(dodecanoylamino)pentanedioate;hydron Chemical compound [Na+].CCCCCCCCCCCC(=O)N[C@H](C([O-])=O)CCC(O)=O IWIUXJGIDSGWDN-UQKRIMTDSA-M 0.000 claims description 10
- 238000003756 stirring Methods 0.000 claims description 10
- NCZPCONIKBICGS-UHFFFAOYSA-N 3-(2-ethylhexoxy)propane-1,2-diol Chemical compound CCCCC(CC)COCC(O)CO NCZPCONIKBICGS-UHFFFAOYSA-N 0.000 claims description 9
- 229940100524 ethylhexylglycerin Drugs 0.000 claims description 9
- LPUQAYUQRXPFSQ-DFWYDOINSA-M monosodium L-glutamate Chemical compound [Na+].[O-]C(=O)[C@@H](N)CCC(O)=O LPUQAYUQRXPFSQ-DFWYDOINSA-M 0.000 claims description 9
- 229940079781 sodium cocoyl glutamate Drugs 0.000 claims description 9
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 8
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 claims description 8
- 229940073507 cocamidopropyl betaine Drugs 0.000 claims description 8
- 238000009472 formulation Methods 0.000 claims description 7
- 238000001816 cooling Methods 0.000 claims description 6
- 229940015975 1,2-hexanediol Drugs 0.000 claims description 5
- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 claims description 5
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 5
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims description 4
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims description 4
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical group [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 4
- 238000007599 discharging Methods 0.000 claims description 4
- PXEDJBXQKAGXNJ-QTNFYWBSSA-L disodium L-glutamate Chemical compound [Na+].[Na+].[O-]C(=O)[C@@H](N)CCC([O-])=O PXEDJBXQKAGXNJ-QTNFYWBSSA-L 0.000 claims description 4
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims description 4
- 229960005150 glycerol Drugs 0.000 claims description 4
- 229960004063 propylene glycol Drugs 0.000 claims description 4
- 239000011780 sodium chloride Substances 0.000 claims description 4
- 229960002668 sodium chloride Drugs 0.000 claims description 4
- UIJMHOVIUFGSNF-UHFFFAOYSA-N 2-[dimethyl-[3-(undec-10-enoylamino)propyl]azaniumyl]acetate Chemical compound [O-]C(=O)C[N+](C)(C)CCCNC(=O)CCCCCCCCC=C UIJMHOVIUFGSNF-UHFFFAOYSA-N 0.000 claims description 3
- JDRSMPFHFNXQRB-CMTNHCDUSA-N Decyl beta-D-threo-hexopyranoside Chemical compound CCCCCCCCCCO[C@@H]1O[C@H](CO)C(O)[C@H](O)C1O JDRSMPFHFNXQRB-CMTNHCDUSA-N 0.000 claims description 3
- 229940073499 decyl glucoside Drugs 0.000 claims description 3
- 229940079779 disodium cocoyl glutamate Drugs 0.000 claims description 3
- PYIDGJJWBIBVIA-UYTYNIKBSA-N lauryl glucoside Chemical compound CCCCCCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O PYIDGJJWBIBVIA-UYTYNIKBSA-N 0.000 claims description 3
- 229940048848 lauryl glucoside Drugs 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 2
- GLZWNFNQMJAZGY-UHFFFAOYSA-N octaethylene glycol Chemical compound OCCOCCOCCOCCOCCOCCOCCOCCO GLZWNFNQMJAZGY-UHFFFAOYSA-N 0.000 claims description 2
- GOJYXPWOUJYXJC-UHFFFAOYSA-M sodium;2-[1-(2-hydroxyethyl)-2-undecyl-4,5-dihydroimidazol-1-ium-1-yl]acetate;hydroxide Chemical compound [OH-].[Na+].CCCCCCCCCCCC1=NCC[N+]1(CCO)CC([O-])=O GOJYXPWOUJYXJC-UHFFFAOYSA-M 0.000 claims 4
- 241000157835 Gardenia Species 0.000 claims 3
- 239000006260 foam Substances 0.000 abstract description 21
- 230000007794 irritation Effects 0.000 abstract description 12
- 230000000694 effects Effects 0.000 abstract description 9
- 241000222122 Candida albicans Species 0.000 abstract description 8
- 241000588724 Escherichia coli Species 0.000 abstract description 8
- 241000589517 Pseudomonas aeruginosa Species 0.000 abstract description 8
- 241000191967 Staphylococcus aureus Species 0.000 abstract description 8
- 229940095731 candida albicans Drugs 0.000 abstract description 8
- 239000000419 plant extract Substances 0.000 abstract description 5
- 230000005764 inhibitory process Effects 0.000 abstract description 3
- 230000002195 synergetic effect Effects 0.000 abstract description 2
- 210000003491 skin Anatomy 0.000 description 43
- 238000012360 testing method Methods 0.000 description 26
- 230000000052 comparative effect Effects 0.000 description 24
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 20
- 244000111489 Gardenia augusta Species 0.000 description 18
- 239000000126 substance Substances 0.000 description 10
- 239000007788 liquid Substances 0.000 description 9
- 238000001514 detection method Methods 0.000 description 8
- -1 coumarin, organic acid Chemical class 0.000 description 7
- 210000003837 chick embryo Anatomy 0.000 description 6
- 239000002537 cosmetic Substances 0.000 description 6
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 6
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical group CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 5
- 208000032843 Hemorrhage Diseases 0.000 description 5
- 208000034158 bleeding Diseases 0.000 description 5
- 230000000740 bleeding effect Effects 0.000 description 5
- 230000006378 damage Effects 0.000 description 5
- 238000011156 evaluation Methods 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- 241000193830 Bacillus <bacterium> Species 0.000 description 4
- 206010061218 Inflammation Diseases 0.000 description 4
- 206010040880 Skin irritation Diseases 0.000 description 4
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 4
- 230000003266 anti-allergic effect Effects 0.000 description 4
- 229930003935 flavonoid Natural products 0.000 description 4
- 235000017173 flavonoids Nutrition 0.000 description 4
- 235000021472 generally recognized as safe Nutrition 0.000 description 4
- 230000002401 inhibitory effect Effects 0.000 description 4
- 230000003020 moisturizing effect Effects 0.000 description 4
- 230000000144 pharmacologic effect Effects 0.000 description 4
- YPFDHNVEDLHUCE-UHFFFAOYSA-N propane-1,3-diol Chemical compound OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 description 4
- 231100000475 skin irritation Toxicity 0.000 description 4
- 230000036556 skin irritation Effects 0.000 description 4
- HVFAVOFILADWEZ-UHFFFAOYSA-M sodium;2-[2-(dodecanoylamino)ethyl-(2-hydroxyethyl)amino]acetate Chemical compound [Na+].CCCCCCCCCCCC(=O)NCCN(CCO)CC([O-])=O HVFAVOFILADWEZ-UHFFFAOYSA-M 0.000 description 4
- 230000000638 stimulation Effects 0.000 description 4
- 239000000341 volatile oil Substances 0.000 description 4
- 244000144730 Amygdalus persica Species 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 3
- 206010015150 Erythema Diseases 0.000 description 3
- 206010015946 Eye irritation Diseases 0.000 description 3
- 235000006040 Prunus persica var persica Nutrition 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 229940024606 amino acid Drugs 0.000 description 3
- 235000001014 amino acid Nutrition 0.000 description 3
- 230000001139 anti-pruritic effect Effects 0.000 description 3
- 239000003908 antipruritic agent Substances 0.000 description 3
- 244000052616 bacterial pathogen Species 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 231100000321 erythema Toxicity 0.000 description 3
- 231100000013 eye irritation Toxicity 0.000 description 3
- 238000005187 foaming Methods 0.000 description 3
- 239000000017 hydrogel Substances 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 208000014674 injury Diseases 0.000 description 3
- 230000004224 protection Effects 0.000 description 3
- 235000018102 proteins Nutrition 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 2
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 2
- 235000007866 Chamaemelum nobile Nutrition 0.000 description 2
- 244000042664 Matricaria chamomilla Species 0.000 description 2
- 235000007232 Matricaria chamomilla Nutrition 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- 208000024248 Vascular System injury Diseases 0.000 description 2
- 208000012339 Vascular injury Diseases 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 230000006838 adverse reaction Effects 0.000 description 2
- 229960000458 allantoin Drugs 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 230000000845 anti-microbial effect Effects 0.000 description 2
- 230000003064 anti-oxidating effect Effects 0.000 description 2
- 230000003385 bacteriostatic effect Effects 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 210000000245 forearm Anatomy 0.000 description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 2
- 231100001267 hazard identification Toxicity 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 230000002427 irreversible effect Effects 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 231100000286 mucous membrane, eye irritation or corrosion testing Toxicity 0.000 description 2
- 238000010926 purge Methods 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 159000000000 sodium salts Chemical class 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 235000018553 tannin Nutrition 0.000 description 2
- 229920001864 tannin Polymers 0.000 description 2
- 239000001648 tannin Substances 0.000 description 2
- 150000003648 triterpenes Chemical class 0.000 description 2
- NPNUFJAVOOONJE-ZIAGYGMSSA-N β-(E)-Caryophyllene Chemical compound C1CC(C)=CCCC(=C)[C@H]2CC(C)(C)[C@@H]21 NPNUFJAVOOONJE-ZIAGYGMSSA-N 0.000 description 2
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 description 1
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 description 1
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 1
- KIUKXJAPPMFGSW-YXBJCWEESA-N (2s,4s,5r,6s)-6-[(2s,3r,5s,6r)-3-acetamido-2-[(3s,4r,5r,6r)-6-[(3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@@H]3[C@@H]([C@@H](O)C(O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)C(C(O)=O)O1 KIUKXJAPPMFGSW-YXBJCWEESA-N 0.000 description 1
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
- OHVLMTFVQDZYHP-UHFFFAOYSA-N 1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)-2-[4-[2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidin-5-yl]piperazin-1-yl]ethanone Chemical compound N1N=NC=2CN(CCC=21)C(CN1CCN(CC1)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)=O OHVLMTFVQDZYHP-UHFFFAOYSA-N 0.000 description 1
- FRPZMMHWLSIFAZ-UHFFFAOYSA-N 10-undecenoic acid Chemical compound OC(=O)CCCCCCCCC=C FRPZMMHWLSIFAZ-UHFFFAOYSA-N 0.000 description 1
- LDXJRKWFNNFDSA-UHFFFAOYSA-N 2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)-1-[4-[2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidin-5-yl]piperazin-1-yl]ethanone Chemical compound C1CN(CC2=NNN=C21)CC(=O)N3CCN(CC3)C4=CN=C(N=C4)NCC5=CC(=CC=C5)OC(F)(F)F LDXJRKWFNNFDSA-UHFFFAOYSA-N 0.000 description 1
- WZFUQSJFWNHZHM-UHFFFAOYSA-N 2-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperazin-1-yl]-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)N1CCN(CC1)CC(=O)N1CC2=C(CC1)NN=N2 WZFUQSJFWNHZHM-UHFFFAOYSA-N 0.000 description 1
- USMNOWBWPHYOEA-UHFFFAOYSA-N 3‐isothujone Chemical compound CC1C(=O)CC2(C(C)C)C1C2 USMNOWBWPHYOEA-UHFFFAOYSA-N 0.000 description 1
- CONKBQPVFMXDOV-QHCPKHFHSA-N 6-[(5S)-5-[[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperazin-1-yl]methyl]-2-oxo-1,3-oxazolidin-3-yl]-3H-1,3-benzoxazol-2-one Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)N1CCN(CC1)C[C@H]1CN(C(O1)=O)C1=CC2=C(NC(O2)=O)C=C1 CONKBQPVFMXDOV-QHCPKHFHSA-N 0.000 description 1
- NVEQFIOZRFFVFW-UHFFFAOYSA-N 9-epi-beta-caryophyllene oxide Natural products C=C1CCC2OC2(C)CCC2C(C)(C)CC21 NVEQFIOZRFFVFW-UHFFFAOYSA-N 0.000 description 1
- 241000197194 Bulla Species 0.000 description 1
- 241000723346 Cinnamomum camphora Species 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- WEEGYLXZBRQIMU-UHFFFAOYSA-N Eucalyptol Chemical compound C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 description 1
- 235000018958 Gardenia augusta Nutrition 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 description 1
- 241000208680 Hamamelis mollis Species 0.000 description 1
- 241000725303 Human immunodeficiency virus Species 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- 240000002129 Malva sylvestris Species 0.000 description 1
- 235000006770 Malva sylvestris Nutrition 0.000 description 1
- 241001448624 Miliaria Species 0.000 description 1
- 102000007474 Multiprotein Complexes Human genes 0.000 description 1
- 108010085220 Multiprotein Complexes Proteins 0.000 description 1
- NIPNSKYNPDTRPC-UHFFFAOYSA-N N-[2-oxo-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 NIPNSKYNPDTRPC-UHFFFAOYSA-N 0.000 description 1
- 244000170916 Paeonia officinalis Species 0.000 description 1
- 235000006484 Paeonia officinalis Nutrition 0.000 description 1
- 206010033733 Papule Diseases 0.000 description 1
- 201000005702 Pertussis Diseases 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- 241000607762 Shigella flexneri Species 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 240000001949 Taraxacum officinale Species 0.000 description 1
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- 208000037386 Typhoid Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- 229940061720 alpha hydroxy acid Drugs 0.000 description 1
- 150000001280 alpha hydroxy acids Chemical class 0.000 description 1
- FAMPSKZZVDUYOS-UHFFFAOYSA-N alpha-Caryophyllene Natural products CC1=CCC(C)(C)C=CCC(C)=CCC1 FAMPSKZZVDUYOS-UHFFFAOYSA-N 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000002155 anti-virotic effect Effects 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 235000003704 aspartic acid Nutrition 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
- NPNUFJAVOOONJE-UHFFFAOYSA-N beta-cariophyllene Natural products C1CC(C)=CCCC(=C)C2CC(C)(C)C21 NPNUFJAVOOONJE-UHFFFAOYSA-N 0.000 description 1
- 229960003237 betaine Drugs 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 208000002352 blister Diseases 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 description 1
- 229940116229 borneol Drugs 0.000 description 1
- 230000005587 bubbling Effects 0.000 description 1
- 235000019437 butane-1,3-diol Nutrition 0.000 description 1
- 229930008380 camphor Natural products 0.000 description 1
- 229960000846 camphor Drugs 0.000 description 1
- KHAVLLBUVKBTBG-UHFFFAOYSA-N caproleic acid Natural products OC(=O)CCCCCCCC=C KHAVLLBUVKBTBG-UHFFFAOYSA-N 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 229940117948 caryophyllene Drugs 0.000 description 1
- NPNUFJAVOOONJE-UONOGXRCSA-N caryophyllene Natural products C1CC(C)=CCCC(=C)[C@@H]2CC(C)(C)[C@@H]21 NPNUFJAVOOONJE-UONOGXRCSA-N 0.000 description 1
- 230000019522 cellular metabolic process Effects 0.000 description 1
- 229940119217 chamomile extract Drugs 0.000 description 1
- 235000020221 chamomile extract Nutrition 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 229960005233 cineole Drugs 0.000 description 1
- RFFOTVCVTJUTAD-UHFFFAOYSA-N cineole Natural products C1CC2(C)CCC1(C(C)C)O2 RFFOTVCVTJUTAD-UHFFFAOYSA-N 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 description 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 210000003278 egg shell Anatomy 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 210000001723 extracellular space Anatomy 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002212 flavone derivatives Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000013376 functional food Nutrition 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000002008 hemorrhagic effect Effects 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 230000007365 immunoregulation Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 125000000400 lauroyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 230000037311 normal skin Effects 0.000 description 1
- 125000002801 octanoyl group Chemical group C(CCCCCCC)(=O)* 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 235000004400 serine Nutrition 0.000 description 1
- 239000011863 silicon-based powder Substances 0.000 description 1
- 206010040872 skin infection Diseases 0.000 description 1
- 230000005808 skin problem Effects 0.000 description 1
- WUWHFEHKUQVYLF-UHFFFAOYSA-M sodium;2-aminoacetate Chemical compound [Na+].NCC([O-])=O WUWHFEHKUQVYLF-UHFFFAOYSA-M 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 229930007110 thujone Natural products 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 201000008297 typhoid fever Diseases 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 229960002703 undecylenic acid Drugs 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- 229940118846 witch hazel Drugs 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses an antibacterial infant care preparation and application thereof. The antibacterial infant care lotion comprises herba Violae extract, flos Gardeniae extract, flos Lonicerae extract and folium Artemisiae Argyi extract. The antibacterial infant care preparation disclosed by the invention selects mild and natural plant extracts from raw materials, has no irritation to skin and eyes, is rich and fine in foam, has a good inhibition effect on escherichia coli, staphylococcus aureus, pseudomonas aeruginosa and candida albicans through the synergistic compatibility of specific components, and has good antibacterial effects as the antibacterial ring diameter of escherichia coli is about 10.0mm, the antibacterial ring diameter of staphylococcus aureus is about 10.0, the antibacterial ring diameter of pseudomonas aeruginosa is about 10.3 and the antibacterial ring diameter of candida albicans is about 10.7.
Description
Technical Field
The invention relates to the technical field of infant care, in particular to an antibacterial infant care preparation and application thereof.
Background
With the continuous improvement of the living standard of China, people pay more and more attention to the daily skin care of infants. The skin of the infant is very fragile, the dermis part is very thin, sebum secretion is easy to dry from three months to six years after birth, so that the infant is easy to be injured and skin problems such as eczema and the like occur, the infant care product also occupies an important position in the infant industry, and the requirement of the market on the infant care product is higher and higher. However, the existing infant washing and caring products still have some problems, such as insufficient antibacterial performance, inconvenience for infant skin care and the like.
Because of the particularity of infant products, various functional components of the infant products seek natural health as much as possible, and therefore plant extracts are widely developed and applied to related infant care products. The plants such as the purple flower, the gardenia and the like have certain efficacy, but at present, the plants are generally developed into functional food or various substitutional tea, and the report that related plant extracts are rarely applied to infant antibacterial washing and protecting products is reported. CN109288762A discloses a baby peach leaf body lotion, which is composed of the following components in parts by weight: phase A component: 40-80 parts of water; 0.1-3 of ZEN; 0.1-3 parts of transparent xanthan gum; 2-5 parts of 1, 3-butanediol; phase B component: 6-10 parts of witch hazel; 0.1-3 parts of dipotassium glycyrrhizinate; phase C component: 2-5 parts of silicon powder; phase D component: 1-3 parts of a chamomile extract; 1-3 parts of malva sylvestris extract; 1-3 parts of a peony root extract; 1-3 parts of honeysuckle flower extract; 1-3 parts of dandelion rhizome extract; 1-3 parts of a Chinese violet extract; 1-3 parts of peach leaf extract; phase E component: 0.06-0.12% of caprylyl hydroximic acid; 0.03-0.08% of ethylhexyl glycerin; 0.2-0.5 of 1, 2-hexanediol and a preparation method thereof. The liquid baby talcum powder mainly improves the comfort level of the existing liquid baby talcum powder, achieves the effect of preventing miliaria through the pharmacological action of extracts such as peach leaves, does not cause powder raising or waste, and can cover the skin to a greater extent. No corresponding technical suggestion for improvement of the antibacterial properties of infant care products is given.
Disclosure of Invention
The invention aims to solve the technical problem of overcoming the defect and the defect that the antibacterial performance of the existing infant washing and caring product needs to be further improved, and provides an antibacterial infant washing and caring preparation.
It is another object of the present invention to provide an antimicrobial infant care formulation for use in infant care products.
It is yet another object of the present invention to provide a baby shampoo bath bubble.
The above purpose of the invention is realized by the following technical scheme:
an antibacterial infant care lotion comprises herba Violae extract, flos Gardeniae extract, flos Lonicerae extract and folium Artemisiae Argyi extract.
The Chinese violet extract, the gardenia extract, the honeysuckle extract and the folium artemisiae argyi extract of the antibacterial infant care preparation are safe and mild plant extract components, are used as additives to be applied to the field of infant care products, are not specifically limited in dosage in general application, are identified by harm, do not find safe risk substances in raw materials, and are safe to use.
The Chinese violet extract, the gardenia extract, the honeysuckle extract and the folium artemisiae argyi extract can be commercially available products or obtained by extraction.
Wherein,
herba Violae: is cold in nature, bitter and pungent in flavor, enters lung and liver meridians, and has the effects of dispelling wind and heat, and relieving swelling and detoxifying. The main components of the Chinese violet contain effective components such as flavone and glycosides thereof, coumarin, organic acid, phenols, tannin, alkaloid, amino acid, protein or polypeptide, saccharides, steroids, volatile oil and the like, and the Chinese violet extract separated by different solvents proves to have the effects of resisting inflammation, inhibiting bacteria, resisting the activity of human immunodeficiency virus, regulating immunity and the like.
Gardenia: cold in nature and sweet and bitter in taste. Has effects in purging pathogenic fire, relieving restlessness, clearing away heat, promoting urination, cooling blood, and removing toxic materials. The gardenia contains a large amount of flavonoid compounds. Pharmacological experiments show that the flavonoid compound has obvious biological activities of resisting ulcer, relieving spasm, resisting inflammation, reducing blood fat and the like.
Honeysuckle flower (honeysuckle flower): sweet in taste and cold in nature, and has the effects of clearing heat and purging fire, eliminating dampness, cooling blood, detoxifying, clearing deficiency heat and the like. The main active ingredients are as follows: organic acid compounds, flavonoid compounds, volatile oil components, triterpenoids and the like. The pharmacological actions of honeysuckle flower are mainly expressed in the aspects of bacteriostasis, antivirus, antipyresis, anti-inflammation, liver protection, hemostasis, antioxidation, immunoregulation and the like. The honeysuckle has stronger inhibiting capability on bacilli such as typhoid bacillus, dysentery bacillus, large intestine bacillus, pseudomonas aeruginosa, pertussis bacillus and the like, and cocci such as staphylococcus, streptococcus, pneumococcus and meningococcus and the like.
Folium artemisiae argyi: the property and taste are bitter and pungent, and slightly warm. Has effects of warming channels, stopping bleeding, relieving pain, dispelling cold, eliminating dampness, regulating qi-flowing, and resolving stagnation. The folium artemisiae argyi contains complex chemical components, mainly contains volatile oil, and then contains flavonoid, tannin, triterpenes, polysaccharides, trace elements and the like, and has wide pharmacological effects of relieving asthma and cough, easing pain and diminishing inflammation, enhancing immunity, resisting bacteria and viruses, stopping bleeding and the like.
The folium Artemisiae Argyi volatile oil contains 30 kinds of components including cineole, caryophyllene, 4-terpinene, borneol, camphor, thujone, etc.
Preferably, the composition comprises the following components in parts by mass: 6-12 parts of a Chinese violet extract, 12-18 parts of a gardenia extract, 5-11 parts of a honeysuckle extract and 6-12 parts of a folium artemisiae argyi extract.
Preferably, the composition comprises the following components in parts by mass: 9 parts of Chinese violet extract, 15 parts of gardenia extract, 8 parts of honeysuckle extract and 9 parts of folium artemisiae argyi extract.
The application of the antibacterial infant care preparation in infant care products is also within the protection scope of the invention.
The invention also provides the infant shampoo and bath bubble which is prepared from the antibacterial infant shampoo and other acceptable auxiliary materials.
Other acceptable adjuvants of the present invention are mild, non-irritating adjuvants known to those skilled in the art that can be added to infant skin care products.
Preferably, the composition comprises the following components in percentage by mass: 13-19% of surfactant, 2.2-2.8% of humectant, 0.06-0.12% of skin conditioner, 0.007-0.013% of hair conditioner, 0.07-0.13% of chelating agent, 0.1-0.5% of solubilizer, 0.6-1.2% of emollient, 0.007-0.013% of pH regulator and the balance of solvent, wherein the skin conditioner comprises an antibacterial infant care preparation.
More preferably, the composition comprises the following components in percentage by mass: 16% of surfactant, 2.5% of humectant, 0.09% of skin conditioner, 0.01% of hair conditioner, 0.1% of chelating agent, 0.2% of solubilizer, 0.9% of emollient, 0.01% of pH regulator and the balance of solvent. Herba Violae extract, Gardenia jasminoides Ellis extract, flos Lonicerae extract and folium Artemisiae Argyi extract
In the skin conditioner, the Chinese violet extract is a mixture of a Chinese violet extract, 1, 2-hexanediol, allantoin and water, wherein the 1, 2-hexanediol is a humectant, the allantoin is an antioxidant, and the water is a solvent.
The gardenia extract skin conditioner comprises water, gardenia extract, 1, 3-propylene glycol, glycerol and ethylhexyl glycerol, wherein the water and the 1, 3-propylene glycol are used as solvents, the glycerol is used as a humectant, and the ethylhexyl glycerol is a novel mild humectant component.
The honeysuckle flower extract skin conditioner comprises water, a honeysuckle flower extract and butanediol, wherein the water is a solvent, and the butanediol is a humectant.
The solvent of the invention is water and propylene glycol, the water is the most common solvent in cosmetics, and the solvent used as other components is a substance generally regarded as safe without safety risk; propylene glycol is a widely used solvent, which is recognized as Generally Recognized As Safe (GRAS) by the FDA in the United states. The maximum safe amount should be less than 50% in the CIR assessment in the United states, and the amount in the formula is within this range without safety risk.
Preferably, the surfactant is one or more of cocamidopropyl betaine, sodium lauroyl glutamate, sodium lauroamphoacetate, sodium cocoyl glutamate, lauryl glucoside, decyl glucoside, disodium cocoyl glutamate or undecylenamidopropyl betaine, the humectant is one or more of glycerol and panthenol, the hair conditioner is one or more of glycerol and sericin, the chelating agent is disodium EDTA, the solubilizer is one or more of PPG-26-butyether-26, PEG-40 hydrogenated castor oil and water, the emollient is one or more of caprylyl glycol and ethylhexyl glycerol, the pH regulator is citric acid, and the solvent is one or more of water and propylene glycol.
The surfactant lauryl glucoside, decyl glucoside, disodium cocoyl glutamate or undecylenic acid amidopropyl betaine and the like are subjected to ECO natural certification, have natural safety, higher mildness and reasonable formula, reduce the addition of stimulus sources at the source and effectively reduce the final stimulus of the product.
The humectant is glycerin and panthenol, wherein the mass ratio of glycerin to panthenol is 1:0.4, glycerin is widely used due to the remarkable moisturizing effect, the American FDA considers that the glycerin belongs to a substance Generally Regarded As Safe (GRAS), the Chinese food and drug administration sets that the glycerin content (w/%) is more than or equal to 95.0 and the diethylene glycol content (w/%) in glycerin is less than or equal to 0.1 in 2011 release glycerin raw material requirement for cosmetics, the quality of the formula meets the standard requirement, the dosage is within the range, and no safety risk exists. Panthenol is often used as a humectant, the maximum safe dosage of which in the CIR evaluation in the united states should be less than 25%, and the dosage in the formula is within this range, so that there is no safety risk;
preferably, the hair conditioner is preferably a mixture of sericin and glycerol.
The sericin is rich in polar amino acids such as serine, aspartic acid, glutamic acid, etc., and is rich in-OH, -COOH, -NH2The hydrophilic groups are highly extended and mutually combined in aqueous solutionThe hydrogel is wound and tightly combined with water molecules through hydrogen bonds to form a continuous network structure, has high water absorption and retention performances, can absorb and retain thousands of times of water of the self-mass of the hydrogel, can combine the water with the skin cuticle to ensure that the skin contains certain water, thereby ensuring that the skin is soft and smooth, has the components and functions similar to natural moisturizing factors of the skin cuticle, effectively enhances the affinity with the main protein cuticle of the skin cuticle, and has the functions of moisturizing, whitening, antioxidation, antibiosis, antiphlogosis, absorption, ultraviolet inhibition and the like on the skin.
Sericin also has the functions of inhibiting the growth of pathogenic bacteria and pathological reaction, namely has the functions of antibiosis and antiphlogosis. When the hydrogel with the continuous network structure formed by tightly combining the hydroxide highly-dense structure in the sericin protein and the hydrogen bonds of water molecules is coated on the surface of skin, a layer of hydration film is easily formed, and the film is like a natural barrier, so that the skin and bacteria can be effectively isolated, the bacteria are prevented from invading the skin, and the antibacterial and anti-inflammatory effects are indirectly generated. In the skin matrix, sericin is combined with protein and exists in intercellular spaces in the form of protein complexes to form gel, so that cells are adhered together, and normal cell metabolism and tissue water retention can be maintained, thereby protecting cells from pathogenic bacteria, preventing skin infection and the like.
Glycerol has moisturizing effect in hair conditioner.
The sericin is used as a hair conditioner, the dosage of the sericin is not particularly limited in general application, and the raw material does not find a safety risk substance through hazard identification and is safe to use; glycerol is a humectant, which is considered to belong to substances Generally Regarded As Safe (GRAS) by the FDA in the United states, and the Chinese food and drug administration stipulates that the content (w/%) of glycerol is more than or equal to 95.0 and the content (w/%) of diethylene glycol in glycerol is less than or equal to 0.1 in the cosmetic raw material requirement published in 2011, so that the quality of the formula meets the standard requirement, the dosage is within the range, and no safety risk exists.
The solubilizer is preferably a mixture of water, PPG-26 Butanethopolyether-26 and PEG-40 hydrogenated castor oil, wherein the ratio of water: PPG-26 Butaneth-26: the mass ratio of the PEG-40 hydrogenated castor oil is 5:4: 1. Water is the most common solvent in cosmetics, and is a substance generally regarded as safe as a solvent of other components, so that no safety risk exists; PPG-26-Butanethol-26 is used as a solubilizer, the maximum safe dosage of the PPG-26-Butanethol-26 in the American CIR evaluation is less than 0.025 percent, and the dosage of the PPG-26-Butanethol-26-solubilizer is within the range without; PEG-40 hydrogenated castor oil is used as a solubilizer, the dosage of the solubilizer is not particularly limited in general application, and the raw material has no safety risk substances through hazard recognition and is safe to use.
The emollient is caprylyl glycol and ethylhexyl glycerin, caprylyl glycol is used as humectant, the maximum safe use concentration of the caprylyl glycol is less than 5% in American CIR evaluation, the use amount of the caprylyl glycol in the formula is within the range, and no safety risk exists; ethylhexyl glycerin is a novel mild humectant ingredient, and its maximum safe use concentration in the us CIR evaluation should be less than 8% (2% in resident products), and the amount in this formula is within this range with no safety risk.
The pH regulator is citric acid, and the citric acid is used as the pH regulator, and the dosage of the pH regulator meets the relevant requirements of 'α -hydroxy acid and salts and esters thereof (6)' in cosmetic limit components (table 3) according to the technical safety standard of cosmetics (2015 edition), and has no safety risk.
Preferably, the skin conditioner is a mixture of lemon peel oil and an antibacterial infant care formulation, wherein the mass content of the lemon peel oil is 20% of the skin conditioner.
Wherein the lemon peel oil is derived from natural plant lemon peel, the dosage of the lemon peel oil is not particularly limited in general application, and after hazard identification, the raw material does not find safe risk substances and is safe to use,
preferably, the surfactant is a complex of cocamidopropyl betaine, sodium lauroyl glutamate, sodium cocoyl glutamate, sodium chloride, propylene glycol, glycerin, and sodium lauroamphoacetate, wherein the ratio of cocamidopropyl betaine: sodium lauroyl glutamate: sodium cocoyl glutamate: the mass ratio of the sodium lauroamphoacetate is 7:7:5: 0.5.
The components of the infant shampoo and bath bubbles, except the solvent water, account for more than 90 percent of the components as the surfactant, so how to select the surfactant, whether the surfactant is natural or not and how to compound the surfactant is very important.
The present invention preferably uses the above-described surfactant,
(1) the experience is good. Has better experience feeling, especially the fineness and the density of the foam.
(2) The safety is guaranteed. As the core main surface of the product is made of raw materials which have small irritation and pass ECO certification, the future irritation detection index is guaranteed.
(3) The cost is controllable. The cost budget result is 12 yuan/kg.
(4) The taste of the raw materials is greatly improved.
The invention also provides a preparation method of the shampoo and bath bubble, which comprises the following steps:
s1, adding the phase A raw material into a water phase pot, stirring and heating to 70-85 ℃; fully and uniformly stirring, and keeping the temperature until the components are completely dissolved;
s2, cooling to 45-55 ℃, adding the phase B raw material, and fully and uniformly stirring;
and S3, cooling to 30-35 ℃, discharging, and standing.
Wherein: phase A raw materials: water, cocamidopropyl betaine, sodium chloride, sodium lauroyl glutamate, sodium cocoyl glutamate, propylene glycol, glycerol, sodium lauroamphoacetate, disodium EDTA;
b phase raw materials:
herba Violae extract, flos Gardeniae extract, flos Lonicerae extract, folium Artemisiae Argyi extract, lemon peel oil, sericin, panthenol, sericin, 1, 2-hexanediol, p-hydroxyacetophenone, octaethylene glycol, PPG-26-butanol polyether-26, PEG-40 hydrogenated castor oil, ethylhexyl glycerol, and citric acid.
Compared with the prior art, the invention has the beneficial effects that:
the invention discloses an antibacterial infant care preparation and application thereof. The antibacterial infant care lotion comprises herba Violae extract, flos Gardeniae extract, flos Lonicerae extract and folium Artemisiae Argyi extract. The antibacterial infant care preparation disclosed by the invention selects mild and natural plant extracts from raw materials, has no irritation to skin and eyes, is rich and fine in foam, has a good inhibition effect on escherichia coli, staphylococcus aureus, pseudomonas aeruginosa and candida albicans through the synergistic compatibility of specific components, and has good antibacterial effects as the antibacterial ring diameter of escherichia coli is about 10.0mm, the antibacterial ring diameter of staphylococcus aureus is about 10.0, the antibacterial ring diameter of pseudomonas aeruginosa is about 10.3 and the antibacterial ring diameter of candida albicans is about 10.7.
Detailed Description
The present invention will be further described with reference to specific embodiments, but the present invention is not limited to the examples in any way. The starting reagents employed in the examples of the present invention are, unless otherwise specified, those that are conventionally purchased.
Example 1
An antibacterial infant washing and caring preparation comprises the following components in parts by weight: the traditional Chinese medicine composition comprises 7 parts of a Chinese violet extract, 13 parts of a gardenia extract, 6 parts of a honeysuckle extract and 10 parts of a folium artemisiae argyi extract.
Example 2
An antibacterial infant washing and caring preparation comprises the following components in parts by weight: 11 parts of Chinese violet extract, 17 parts of gardenia extract, 10 parts of honeysuckle extract and 11 parts of folium artemisiae argyi extract.
Example 3
An antibacterial infant washing and caring preparation comprises the following components in parts by weight: 9 parts of Chinese violet extract, 15 parts of gardenia extract, 8 parts of honeysuckle extract and 9 parts of folium artemisiae argyi extract.
Example 4
An antibacterial infant washing and caring preparation comprises the following components in parts by weight: 13 parts of Chinese violet extract, 11 parts of gardenia extract, 10 parts of honeysuckle extract and 13 parts of folium artemisiae argyi extract.
Example 5
An antibacterial infant washing and caring preparation comprises the following components in parts by weight: 11 parts of Chinese violet extract, 14 parts of gardenia extract, 12 parts of honeysuckle extract and 5 parts of folium artemisiae argyi extract.
Example 6
The infant shampoo and bath bubble comprises the following components in percentage by mass: 16% of surfactant, 2.5% of humectant, 0.09% of skin conditioner, 0.01% of hair conditioner, 0.1% of chelating agent, 0.2% of solubilizer, 0.9% of emollient, 0.01% of pH regulator and the balance of solvent. The surfactants are shown in table 1 below:
TABLE 1
The skin conditioner is a mixture of lemon peel oil and an antibacterial infant care preparation, wherein the mass content of the lemon peel oil is 20% of that of the skin conditioner, and the antibacterial infant care preparation is the antibacterial infant care preparation in example 3.
The chelating agent is EDTA disodium;
the humectant is glycerol and panthenol, wherein the mass ratio of the glycerol to the panthenol is 1: 0.4;
the solvent is water and propylene glycol;
the solubilizer is a mixture of water, PPG-26 butanol polyether-26 and PEG-40 hydrogenated castor oil, wherein the ratio of PPG-26 butanol polyether-26: the mass ratio of the PEG-40 hydrogenated castor oil is 5:4: 1;
the emollient is caprylyl glycol and ethylhexyl glycerin;
the pH regulator is citric acid.
Example 7
The infant shampoo and bath bubble comprises the following components in percentage by mass: 16% of surfactant, 2.5% of humectant, 0.09% of skin conditioner, 0.01% of hair conditioner, 0.1% of chelating agent, 0.2% of solubilizer, 0.9% of emollient, 0.01% of pH regulator and the balance of solvent. The surfactants are shown in table 2 below:
TABLE 2
| Name of raw materials | Percentage of | Remarks for note |
| Cocoyl glycine sodium salt | 7.20 | ECO Natural authentication |
| Lauroyl oat amino acid sodium salt | 6.00 | ECO Natural authentication |
| Lauroamphoacetate sodium salt | 2.00 | / |
| Sodium lauroyl glutamate | 2.00 | / |
| Hyaluronic acid sodium salt | 0.100 | / |
| Water of chamomile | 10.00 | / |
| Glycerol | 3.000 | / |
The skin conditioner is a mixture of lemon peel oil and an antibacterial infant care preparation, wherein the mass content of the lemon peel oil is 20% of that of the skin conditioner, and the antibacterial infant care preparation is the antibacterial infant care preparation in example 3.
The chelating agent is EDTA disodium;
the humectant is glycerol and panthenol, wherein the mass ratio of the glycerol to the panthenol is 1: 0.4;
the solvent is water and propylene glycol;
the solubilizer is a mixture of water, PPG-26 butanol polyether-26 and PEG-40 hydrogenated castor oil, wherein the ratio of PPG-26 butanol polyether-26: the mass ratio of the PEG-40 hydrogenated castor oil is 5:4: 1;
the emollient is caprylyl glycol and ethylhexyl glycerin;
the pH regulator is citric acid.
Example 8
The infant shampoo and bath bubble comprises the following components in percentage by mass: 16% of surfactant, 2.5% of humectant, 0.09% of skin conditioner, 0.01% of hair conditioner, 0.1% of chelating agent, 0.2% of solubilizer, 0.9% of emollient, 0.01% of pH regulator and the balance of solvent. The surfactants are shown in table 3 below:
TABLE 3
| Name of raw materials | Percentage of | Remarks for note |
| Cocoiloyl disodium glutamate | 5.00 | ECO Natural authentication |
| Undecylenamidopropyl betaine | 5.00 | ECO Natural authentication |
| Lauroamphoacetate sodium salt | 5.00 | / |
| Sodium lauroyl glutamate | 2.00 | / |
| Glycerol | 3.00 | / |
| Polyglycerol-10 | 1.00 | / |
| Water of chamomile | 10.00 | / |
The skin conditioner is a mixture of lemon peel oil and an antibacterial infant care preparation, wherein the mass content of the lemon peel oil is 20% of that of the skin conditioner, and the antibacterial infant care preparation is the antibacterial infant care preparation in example 3.
The chelating agent is EDTA disodium;
the humectant is glycerol and panthenol, wherein the mass ratio of the glycerol to the panthenol is 1: 0.4;
the solvent is water and propylene glycol;
the solubilizer is a mixture of water, PPG-26 butanol polyether-26 and PEG-40 hydrogenated castor oil, wherein the ratio of PPG-26 butanol polyether-26: the mass ratio of the PEG-40 hydrogenated castor oil is 5:4: 1;
the emollient is caprylyl glycol and ethylhexyl glycerin;
the pH regulator is citric acid.
Example 9
The infant shampoo and bath bubble comprises the following components in percentage by mass: 16% of surfactant, 2.5% of humectant, 0.09% of skin conditioner, 0.01% of hair conditioner, 0.1% of chelating agent, 0.2% of solubilizer, 0.9% of emollient, 0.01% of pH regulator and the balance of solvent. The surfactants are shown in table 4 below:
TABLE 4
The skin conditioner is a mixture of lemon peel oil and an antibacterial infant care preparation, wherein the mass content of the lemon peel oil is 20% of that of the skin conditioner, and the antibacterial infant care preparation is the antibacterial infant care preparation in example 3.
The chelating agent is EDTA disodium;
the humectant is glycerol and panthenol, wherein the mass ratio of the glycerol to the panthenol is 1: 0.4;
the solvent is water and propylene glycol;
the solubilizer is a mixture of water, PPG-26 butanol polyether-26 and PEG-40 hydrogenated castor oil, wherein the ratio of PPG-26 butanol polyether-26: the mass ratio of the PEG-40 hydrogenated castor oil is 5:4: 1;
the emollient is caprylyl glycol and ethylhexyl glycerin;
the pH regulator is citric acid.
Example 10
The infant shampoo and bath bubble comprises the following components in percentage by mass: 19% of surfactant, 2.2% of humectant, 0.06% of skin conditioner, 0.013% of hair conditioner, 0.07% of chelating agent, 0.1% of solubilizer, 0.6% of emollient, 0.007% of pH regulator and the balance of solvent. The surfactant is as shown in table 4 below,
the skin conditioner is a mixture of lemon peel oil and an antibacterial infant care preparation, wherein the mass content of the lemon peel oil is 20% of that of the skin conditioner, and the antibacterial infant care preparation is the antibacterial infant care preparation in example 3.
The chelating agent is EDTA disodium;
the humectant is glycerol and panthenol, wherein the mass ratio of the glycerol to the panthenol is 1: 0.4;
the solvent is water and propylene glycol;
the solubilizer is a mixture of water, PPG-26 butanol polyether-26 and PEG-40 hydrogenated castor oil, wherein the ratio of PPG-26 butanol polyether-26: the mass ratio of the PEG-40 hydrogenated castor oil is 5:4: 1;
the emollient is caprylyl glycol and ethylhexyl glycerin;
the pH regulator is citric acid.
Comparative example 1
An antibacterial infant washing and caring preparation comprises the following components in parts by weight: 11 parts of a Chinese violet extract, 15 parts of a gardenia extract and 6 parts of a honeysuckle extract.
Comparative example 2
An antibacterial infant washing and caring preparation comprises the following components in parts by weight: 14 parts of gardenia extract, 7 parts of honeysuckle extract and 9 parts of folium artemisiae argyi extract.
Comparative example 3
An antibacterial infant washing and caring preparation comprises the following components in parts by weight: 9 parts of Chinese violet extract, 8 parts of honeysuckle extract and 9 parts of folium artemisiae argyi extract.
Comparative example 4
An antibacterial infant washing and caring preparation comprises the following components in parts by weight: 9 parts of a Chinese violet extract, 15 parts of a gardenia extract and 8 parts of a folium artemisiae argyi extract.
Result detection
1. Experiment for inhibiting bacteria
The products of the examples and comparative examples were tested for antimicrobial activity.
The detection method comprises the following steps: the infant bath bubbles prepared in examples 1 to 10 of the present invention and comparative examples 1 to 4 were used to respectively perform bacteriostatic tests on known strains of escherichia coli, staphylococcus aureus, pseudomonas aeruginosa and candida albicans, after 12 hours, the test results are shown in the following table, wherein the strains in the following table are all test strains, have no specificity requirements, and can be isolated by a conventional method, and the sizes of the strains are shown in table 5:
TABLE 5
| Test strains | Staphylococcus aureus | Shigella flexneri | Escherichia coli | Candida albicans |
| Diameter of antibacterial ring (mm) | 10.2 | 10.1 | 10.4 | 10.8 |
The results are shown in table 6 below:
TABLE 6 bacteriostatic ring diameter (mm) of product against E.coli, Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans
| Serial number | Escherichia coli | Staphylococcus aureus | Pseudomonas aeruginosa | Candida albicans |
| Example 1 | 10.1 | 10.2 | 10.3 | 10.8 |
| Example 2 | 10.2 | 10.1 | 10.5 | 10.9 |
| Example 3 | 10.1 | 10.3 | 10.5 | 10.9 |
| Example 4 | 10.4 | 10.5 | 10.6 | 11.2 |
| Example 5 | 10.3 | 10.4 | 10.8 | 11.1 |
| Example 6 | 10.3 | 10.0 | 10.4 | 10.9 |
| Example 7 | 10.2 | 10.1 | 10.6 | 10.7 |
| Example 8 | 10.1 | 10.2 | 10.5 | 10.9 |
| Example 9 | 10.0 | 10.0 | 10.3 | 11.0 |
| Example 10 | 10.2 | 10.3 | 10.4 | 10.9 |
| Comparative example 1 | 11.3 | 11.0 | 11.8 | 12.0 |
| Comparative example 2 | 11.2 | 11.3 | 11.7 | 12.1 |
| Comparative example 3 | 11.3 | 11.1 | 11.8 | 12.0 |
| Comparative example 4 | 11.2 | 11.3 | 11.9 | 11.9 |
The experiments show that the diameter of the antibacterial ring of the strain is about the range of the test strain, the long-acting and durable antibacterial effect is achieved, and the minimum antibacterial concentration is measured.
2. And (3) anti-allergy test:
the anti-sensitivity test is then a irritation test, comprising two tests: skin irritation and eye irritation tests; skin irritation was tested using a patch test and eye irritation was tested using chick embryos.
(1) Skin irritation detection
The detection method comprises the following steps:
placing the test substance into the patch chamber in an amount of about 0.020g to about 0.025g (solid or semi-solid) or about 0.020mL to about 0.025mL (liquid),
cleaning the test area of forearm skin, collecting the test site and recording
If the patch applicator is directly attached to the skin of the test area of the forearm, the tested part cannot contact water and cannot be directly exposed to the sunlight, and the patch is kept for 24 h.
After 24 hours, the patch was removed and the scores were observed after 24 hours, 48 hours and 96 hours.
When adverse reactions occur, erythema and edema can be observed. The method of assessing edema is to observe the border of the skin bordering normal skin at the site of adverse reaction.
The evaluation method comprises the following steps:
negative (-) by: the applied part has no reaction, or only the pasting part of the adhesive plaster turns red, but the center does not turn red.
(±) suspicious: itching or only faint (unclear) erythema at the test site.
(+) weak positive: erythema, infiltrates, papules, small blisters.
(++) mid-positive: scattered in the pimple and obvious in pruritus.
Strong positive (+++): red and swollen with bulla.
TABLE 7 Table of observation results after 24h, 48h, and 96h removal of patch applicator
| 24h test results | 48h test results | 96h test results | |
| Example 1 | - | - | - |
| Example 2 | - | - | - |
| Example 3 | - | - | - |
| Example 4 | ± | - | - |
| Example 5 | ± | - | - |
| Example 6 | - | - | - |
| Example 7 | - | - | - |
| Example 8 | - | - | - |
| Example 9 | - | - | - |
| Example 10 | - | - | - |
| Comparative example 1 | ± | - | - |
| Comparative example 2 | ± | ± | - |
| Comparative example 3 | ± | - | - |
| Comparative example 4 | ± | ± | ± |
As can be seen from the data in Table 7, the patch test results of the antipruritic and anti-allergy infant care lotion disclosed by the invention show that the antipruritic and anti-allergy infant care lotion is negative and has no irritation to the skin, while the patch test results of the comparative example show that the antipruritic and anti-allergy infant care lotion has doubtful property and potential safety hazard of skin irritation.
(2) Eye irritation test
The detection method comprises the following steps:
at the same test concentration, 10 chick embryos were randomly selected for testing.
The test sample, SLS or solvent 40UI, was added to the built-in ring of each chick embryo.
The chick embryos are placed in an incubator environment for 30 +/-5 min.
After incubation for 30 +/-5 min, the chick embryos are taken out of the incubator for scoring, the closed preservative film is removed, and the eggshells are peeled off to increase the CAM visual field.
Intra-loop vascular injury was assessed by observing and comparing changes in intra-and extra-loop CAM vessels under auxiliary light (with the aid of a stereomicroscope).
Blood vessel changes were recorded for each chick embryo by photographing.
Grading standard:
TABLE 8
Analysis of results
① NC value comparing the irritation level of the test subjects based on the average size of the vascular injury score (i.e., NC value).
② score criteria:
"0 < NC ≦ 2" indicates a stressful stimulation, i.e. no damage stimulation. The capillary vessels were not damaged by bleeding at this time.
"2 < NC. ltoreq.3" is expressed as a mild stimulus, i.e.a mild damaging stimulus has already been produced at this time. At this time, the capillary vessels developed mild hemorrhagic lesions.
"3 < NC.ltoreq.5" is indicative of moderate stimulation, i.e. when more severe damaging stimulation has occurred. At this time, the capillary vessels are suffered from severe bleeding injury, which may be irreversible injury.
"NC > 5" appears to be a severe stimulus, i.e., when very severe damaging stimuli have been produced. At this time, the capillary vessels bleed over a large area, and the bleeding volume is large, which is an irreversible injury.
The results are shown in Table 9:
TABLE 9
| NC value | |
| Example 1 | 0 |
| Example 2 | 0 |
| Example 3 | 0 |
| Example 4 | 1 |
| Example 5 | 1 |
| Example 6 | 0 |
| Example 7 | 0 |
| Example 8 | 0 |
| Example 9 | 0 |
| Example 10 | 0 |
| Comparative example 1 | 3 |
| Comparative example 2 | 3 |
| Comparative example 3 | 2 |
| Comparative example 4 | 2 |
As can be seen from the eye irritation experimental data in table 9, the formulations of the examples of the present invention were basically tested for irritability, i.e., no irritation, were safe and mild without eye irritation.
3. Product foam test
The test method comprises the following steps: (foam tester, model R-2000, from Western turret of Germany)
The test was carried out using a foam tester using the stirring method: 250mL of the test solution was added to the vector cup and the volume of foam generated at this time was recorded with stirring at 1000rpm for 60 s. Stirring was continued at 1000rpm until 50mL of liquid was drained from the foam and the time required to stir the foam until 50mL of liquid was drained was recorded.
The amount of foam generated by the first 60s of agitation is a measure of the foaming capacity of the solution, with greater volume indicating greater foaming of the shampoo shower bubbles of the formulation; the time t(s) required for 50mL of liquid to drain from the foam was recorded and the stability of the foam was measured by the time t(s) required for the liquid to drain from the foam.
And (4) judging the standard: the foam was judged to be abundant when 50ml of foam was discharged in 12S.
The results are shown in Table 10.
Watch 10
| Foam volume (mL) | Time(s) for discharging 50mL of liquid by bubbling | |
| Example 1 | 755 | 11.3 |
| Example 2 | 770 | 11.4 |
| Example 3 | 720 | 10.9 |
| Example 4 | 690 | 9.6 |
| Example 5 | 685 | 9.9 |
| Example 6 | 700 | 9.5 |
| Example 7 | 720 | 11.2 |
| Example 8 | 740 | 11.0 |
| Example 9 | 705 | 9.4 |
| Example 10 | 760 | 11.3 |
| Comparative example 1 | 550 | 7.3 |
| Comparative example 2 | 560 | 7.2 |
| Comparative example 3 | 570 | 6.8 |
| Comparative example 4 | 565 | 7.2 |
As can be seen from the data in Table 5, the product of the present invention has a rich foam amount, the stronger the foaming ability, and the significantly longer the time required for discharging 50mL of liquid in the foam, compared to the comparative example, and has excellent foam stability.
4. Experiment of population use
The infant shampoo and bath bubbles of examples 6-9 were subjected to a population use experiment,
the specific results are as follows:
examples 6 to 8:
1. the experience is good. The products of 3 formulas have better experience feeling, especially the fineness of foam.
2. The safety is guaranteed. As the core main surface of the product is made of raw materials which have small irritation and pass ECO certification, the future irritation detection index is guaranteed.
3. The cost is too high. The cost budget result shows that the cost of the product body is 36-56 yuan/kg.
4. The raw material taste is too heavy. The odor of the raw materials is relatively large.
Example 9:
1. the experience is good. Has better experience feeling, especially the fineness and the density of the foam.
2. The safety is guaranteed. As the core main surface of the product is made of raw materials which have small irritation and pass ECO certification, the future irritation detection index is guaranteed.
3. The cost is controllable. The cost budget result is 12 yuan/kg
4. The raw material taste is greatly improved, and the smell is mainly caused by sodium cocoyl glutamate.
It should be understood that the above-described embodiments of the present invention are merely examples for clearly illustrating the present invention, and are not intended to limit the embodiments of the present invention. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. Any modification, equivalent replacement, and improvement made within the spirit and principle of the present invention should be included in the protection scope of the claims of the present invention.
Claims (10)
1. An antibacterial infant care lotion is characterized by comprising a Chinese violet extract, a gardenia extract, a honeysuckle extract and a folium artemisiae argyi extract.
2. The antibacterial infant care formulation according to claim 1, which comprises the following components in parts by mass: 6-12 parts of a Chinese violet extract, 12-18 parts of a gardenia extract, 5-11 parts of a honeysuckle extract and 6-12 parts of a folium artemisiae argyi extract.
3. The antibacterial infant care formulation according to claim 2, which comprises the following components in parts by mass: 9 parts of Chinese violet extract, 15 parts of gardenia extract, 8 parts of honeysuckle extract and 9 parts of folium artemisiae argyi extract.
4. Use of an antibacterial infant care formulation according to any one of claims 1 to 3 in infant care products.
5. A baby shampoo and bath bubble which is characterized in that the baby shampoo and bath bubble is prepared from the antibacterial baby care preparation as claimed in any one of claims 1 to 3 and other acceptable auxiliary materials.
6. The infant shampoo bath bubble of claim 5, comprising the following components in mass percent: 13-19% of surfactant, 2.2-2.8% of humectant, 0.06-0.12% of skin conditioner, 0.007-0.013% of hair conditioner, 0.07-0.13% of chelating agent, 0.1-0.5% of solubilizer, 0.6-1.2% of emollient, 0.007-0.013% of pH regulator and the balance of solvent, wherein the skin conditioner comprises an antibacterial infant care preparation.
7. The infant shampoo bath bubble of claim 6, comprising the following components in mass percent: 16% of surfactant, 2.5% of humectant, 0.09% of skin conditioner, 0.01% of hair conditioner, 0.1% of chelating agent, 0.2% of solubilizer, 0.9% of emollient, 0.01% of pH regulator and the balance of solvent.
8. The infant shampoo bath bubble of claim 7, wherein the surfactant is one or more of cocamidopropyl betaine, sodium lauroyl glutamate, sodium lauroamphoacetate, sodium cocoyl glutamate, lauryl glucoside, decyl glucoside, disodium cocoyl glutamate, or undecylenamidopropyl betaine, the humectant is one or more of glycerol and panthenol, the hair conditioner is one or more of glycerol and sericin, the chelating agent is disodium EDTA, the solubilizer is one or more of PPG-26-butanol polyether-26, PEG-40 hydrogenated castor oil and water, the emollient is one or more of caprylyl glycol and ethylhexyl glycerin, the pH regulator is citric acid, and the solvent is one or more of water and propylene glycol.
9. The infant shampoo bath bubble of claim 8, wherein the surfactant is a combination of cocamidopropyl betaine, sodium lauroyl glutamate, sodium cocoyl glutamate, sodium chloride, propylene glycol, glycerin, and sodium lauroamphoacetate, wherein the ratio of cocamidopropyl betaine: sodium lauroyl glutamate: sodium cocoyl glutamate: the mass ratio of the sodium lauroamphoacetate is 7:7:5: 0.5.
10. The method for preparing infant shampoo and bath bubbles according to any one of claims 5 to 9, comprising the steps of:
s1, adding the phase A raw material into a water phase pot, stirring and heating to 70-85 ℃; fully and uniformly stirring, and keeping the temperature until the components are completely dissolved;
s2, cooling to 45-55 ℃, adding the phase B raw material, and fully and uniformly stirring;
and S3, cooling to 30-35 ℃, discharging, and standing.
Wherein: phase A raw materials: water, cocamidopropyl betaine, sodium chloride, sodium lauroyl glutamate, sodium cocoyl glutamate, propylene glycol, glycerol, sodium lauroamphoacetate, disodium EDTA;
b phase raw materials:
herba Violae extract, flos Gardeniae extract, flos Lonicerae extract, folium Artemisiae Argyi extract, lemon peel oil, sericin, panthenol, sericin, 1, 2-hexanediol, p-hydroxyacetophenone, octaethylene glycol, PPG-26-butanol polyether-26, PEG-40 hydrogenated castor oil, ethylhexyl glycerol, and citric acid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911221080.2A CN110755331B (en) | 2019-12-03 | 2019-12-03 | Antibacterial infant washing and caring preparation and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911221080.2A CN110755331B (en) | 2019-12-03 | 2019-12-03 | Antibacterial infant washing and caring preparation and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110755331A true CN110755331A (en) | 2020-02-07 |
| CN110755331B CN110755331B (en) | 2022-11-04 |
Family
ID=69340932
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201911221080.2A Active CN110755331B (en) | 2019-12-03 | 2019-12-03 | Antibacterial infant washing and caring preparation and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110755331B (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111110577A (en) * | 2020-02-27 | 2020-05-08 | 陈洁兴 | Mild mite-removing itching-relieving shower gel and preparation method thereof |
| CN111388370A (en) * | 2020-04-02 | 2020-07-10 | 广州市逸轩精细化工有限公司 | Hair and bath two-in-one washing and protecting lotion for children and preparation method thereof |
| CN111973514A (en) * | 2020-08-27 | 2020-11-24 | 刘克武 | Artemisia argyi shampoo for children |
| CN111973474A (en) * | 2020-08-27 | 2020-11-24 | 刘克武 | Wormwood children shower gel |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20110058948A (en) * | 2009-11-27 | 2011-06-02 | (주)아모레퍼시픽 | Antibacterial detergent composition |
| CN103637944A (en) * | 2013-12-04 | 2014-03-19 | 佛山市新战略知识产权文化有限公司 | Natural anti-bacterial shower gel |
| CN105168667A (en) * | 2015-10-27 | 2015-12-23 | 上海海洋大学 | Application of Chinese herbal medicament to delaying of bacterial drug resistance |
| CN105943463A (en) * | 2016-06-23 | 2016-09-21 | 金日制药（中国）有限公司 | Mild shampoo and bath bubbles for infants |
| CN106667839A (en) * | 2017-01-10 | 2017-05-17 | 广州小蜜蜂生物科技有限公司 | Herbal shampoo and bath foam for infant |
| CN109758420A (en) * | 2019-03-30 | 2019-05-17 | 福建省梦娇兰日用化学品有限公司 | A kind of infant containing various plants antipathogenic composition baths bath foam |
-
2019
- 2019-12-03 CN CN201911221080.2A patent/CN110755331B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20110058948A (en) * | 2009-11-27 | 2011-06-02 | (주)아모레퍼시픽 | Antibacterial detergent composition |
| CN103637944A (en) * | 2013-12-04 | 2014-03-19 | 佛山市新战略知识产权文化有限公司 | Natural anti-bacterial shower gel |
| CN105168667A (en) * | 2015-10-27 | 2015-12-23 | 上海海洋大学 | Application of Chinese herbal medicament to delaying of bacterial drug resistance |
| CN105943463A (en) * | 2016-06-23 | 2016-09-21 | 金日制药（中国）有限公司 | Mild shampoo and bath bubbles for infants |
| CN106667839A (en) * | 2017-01-10 | 2017-05-17 | 广州小蜜蜂生物科技有限公司 | Herbal shampoo and bath foam for infant |
| CN109758420A (en) * | 2019-03-30 | 2019-05-17 | 福建省梦娇兰日用化学品有限公司 | A kind of infant containing various plants antipathogenic composition baths bath foam |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111110577A (en) * | 2020-02-27 | 2020-05-08 | 陈洁兴 | Mild mite-removing itching-relieving shower gel and preparation method thereof |
| CN111388370A (en) * | 2020-04-02 | 2020-07-10 | 广州市逸轩精细化工有限公司 | Hair and bath two-in-one washing and protecting lotion for children and preparation method thereof |
| CN111973514A (en) * | 2020-08-27 | 2020-11-24 | 刘克武 | Artemisia argyi shampoo for children |
| CN111973474A (en) * | 2020-08-27 | 2020-11-24 | 刘克武 | Wormwood children shower gel |
Also Published As
| Publication number | Publication date |
|---|---|
| CN110755331B (en) | 2022-11-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN110755331B (en) | Antibacterial infant washing and caring preparation and application thereof | |
| CN110787091B (en) | Itching-relieving and anti-allergy infant washing and protecting preparation and application thereof | |
| CN109157451B (en) | Acne-removing facial cleanser | |
| CN110090190B (en) | Soothing cooling liquid for baby plants and preparation method thereof | |
| CN111110577B (en) | Mild mite-removing itching-relieving shower gel and preparation method thereof | |
| CN107998028A (en) | A kind of shower cream and preparation method thereof | |
| CN107174560B (en) | Mild moisturizing and relieving cleansing water and preparation method thereof | |
| CN105998195A (en) | Cannabis extract with anti-sensitive and moisture retention functions and application thereof | |
| CN108685769A (en) | A kind of herbal mixture black hair anticreep shampoo and preparation method thereof | |
| CN110742819A (en) | Amino acid facial cleansing honey | |
| CN108852951A (en) | A kind of moistening and cleaning skin composition and plant body wash | |
| CN109260075A (en) | A kind of anti-acne opsonic water | |
| CN105997725B (en) | A kind of pure natural bamboo liquid wet tissue and preparation method thereof | |
| CN114939087A (en) | Facial mask and preparation method thereof | |
| CN109453094B (en) | Mosquito-repelling and itching-relieving composition and skin care product containing composition | |
| CN106726869A (en) | A kind of shampoo of natural no stimulation and preparation method thereof | |
| CN109939193A (en) | A kind of composition for treating skin eczema, preparation and preparation method and application | |
| JPWO2012042970A1 (en) | Preventive or therapeutic agent for atopic dermatitis, and external preparation | |
| CN112402308A (en) | Multi-effect relieving moisturizing lotion and preparation method thereof | |
| CN114146030A (en) | Itching-relieving and soothing shower gel and preparation method thereof | |
| CN114366693B (en) | Shampoo bath lotion for infants | |
| CN108186440A (en) | Can antibiotic skin-care Chinese medicinal plant shower cream and its preparation method and application | |
| CN107049866B (en) | Antiallergic plant composition and application thereof | |
| CN111481597B (en) | Female herbal bacteriostatic care solution and preparation method thereof | |
| CN114306526A (en) | Compound broadleaf holly leaf traditional Chinese medicine extract and application thereof in preparing shower gel or hand sanitizer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |