CN104906028A - Yeast composite capable of improving skin and application thereof - Google Patents
Yeast composite capable of improving skin and application thereof Download PDFInfo
- Publication number
- CN104906028A CN104906028A CN201510381658.6A CN201510381658A CN104906028A CN 104906028 A CN104906028 A CN 104906028A CN 201510381658 A CN201510381658 A CN 201510381658A CN 104906028 A CN104906028 A CN 104906028A
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- fermented product
- skin
- fermentation
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Landscapes
- Cosmetics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a yeast composite capable of improving skin, cosmetics taking the yeast composite as the major, and application of the yeast composite. The yeast composite is prepared from the raw materials containing a CFTE (Chinese herbal medicines, polyphenol containing fruits, tea and edible mushrooms) culture medium, and ETS (edible mushrooms, tea and soybean) yeast seed liquid. The yeast composite is prepared by a scientific manner on the basis of skin science, traditional Chinese medicine, biology and related studies, and is multifunctional and obvious in functions, representing by high oxidation resistance, anti-inflammatory effect, anti-irritating performance, acne treatment, and relieving and recovery promoting of local slightly-damaged skin; the yeast composite can reduce the blackspot after the damaged skin is recovered, and is remarkable in wrinkle resisting, whitening, moisturizing and other functions, comfortable and safe to use, and free of skin irritating.
Description
Technical field
The present invention relates to a kind of fermented product composition and the application thereof that improve skin problem, particularly relate to fermented product composition prepared by a kind of applying biological fermentation technique and the application in cosmetics thereof, there is good antioxidation, antiinflammatory, irritation, anti-acne, releive, promote that local slightly damaged skin recovers, reduce skin injury recover after spot formed, and have the effects such as excellent crease-resistant, whitening, moisturizing.
Background technology
With age, the skin of people can change due to endogenous, extrinsic factor impact.Affect by endogenous factor, in skin, collagen protein, elastin laminin, hyaluronic acid and glycoprotein synthesis capability decline, Cytoplasm and intercellular substance flowing reduce, and be embodied in xerosis cutis, elasticity reduces, cutis laxa, occur wrinkle, simultaneously thinning of skin, smegma reduces, immune cell function and cytoactive reduce, and repair function goes down; Extrinsic factor comprise exposure in the sun, be exposed to humiture change environment in, be exposed in the air of pollution, the increase of free radical and harmful active oxygen etc., not only cause the damage of thinning of skin, barrier function, wrinkle increases, elasticity reduces, also making the colour of skin gloomy, there is condition susceptible in skin.
Good skin quality is the important external embodiment of physical beauty, and therefore skin protection is closely related with everyone.Society, is not only women and get used to the skin problem using various types of other skin care item to solve oneself, also has increasing male to start to accept and attempts daily cleaning and the maintenance of use skin care item.Cosmetics have become the necessary of people's lives.
On domestic market, alternative cosmetics brand is a lot, no matter high, medium and low gear brand nearly all has whitening, moisturizing, compacts, anti-ageing effect of waiting for a long time, unification is very serious, actual effect is not obvious, and what have is also irritant and easily cause allergy to skin.
The well-known cosmetics brand in the expensive world, consumer is after using the product a period of time under these brands, and effect is also undesirable.
Cosmetics in China brand also increases rapidly in recent years, but most of enterprise thinks little of research and development.Some products are that a concept does not have actual effect or DeGrain; Selected by some products, raw material thinks little of material quality, containing impurity skin being had to larger stimulation in raw material, makes skin occur disease, as pigmentation after contact hypersensitivity dermatitis, irritant dermatitis, inflammation etc.; Also have some products to pursue immediate effect, do not stint in cosmetic formulations, to add some cosmetics forbidding raw material, immediate effect is obvious, but side effect is large, damages, have influence on physical and mental health to consumer.
Domestic and international research display plant extract is as cosmetic active ingredient, and have lot of advantages, overcome the shortcoming that Traditional makeup relies on synthetic, the security performance of product is higher; Natural constituents is more easily absorbed by the skin, and action effect is more remarkable, functional more outstanding etc.Therefore, plant extract is applied in cosmetics is the inexorable trend of market development.In addition, plant extract has many obvious advantages: source is wide, the mechanism of action is with strong points, and its functional component and related action mechanism be it is found that gradually and confirm, the curative effect in sun-proof, whitening, defying age, sterilization, antiallergic etc.
But plant ingredient is very complicated, existing effective ingredient, has again invalid components and toxic component.Therefore, Chinese herbal medicine extracting is the most important for the inherent quality and clinical efficacy improving Chinese medicine preparation.But conventional extracting method (as decocting method, circumfluence method, infusion process, percolation etc.) is at reservation effective ingredient, remove invalid components aspect, there is the shortcomings such as loss of effective components is large, the cycle is long, operation is many, extraction ratio is not high, interpolation organic solvent.
Summary of the invention
The present invention utilizes Chinese herbal medicine, fruit and vegerable, Folium Camelliae sinensis functional component in conjunction with edible fungi submerged fermentation technology, by the further efficacy enhancing and toxicity reducing of microorganism, by zest decomposition of components or conversion, can alleviate skin irritation.Be sure of now that the fermented product prepared by microorganism has positive effect to skin, thus this fermented product composition is applied to cosmetics.The materials such as the tea polyphenols be rich in said composition, fruit polyphenol, Aloe polysaccharide, ginsenoside, ginseng polysaccharide, thin sesame polysaccharide, soy bean protein hydrolysate, several amino acids and trace element, with the edible fungus fermented product component in ferment filtrate, there is synergism, and easier skin absorbs, thus there is the effects such as antioxidation, defying age, antiinflammatory, antiallergic, whitening, reparation, moisturizing significantly.
In sweat, issuable various enzyme and the very strong microorganism species of capacity of decomposition, can be degraded to small-molecule active substance by the macromole active substance be not easily absorbed by the body, and is easier to Skin Cell and absorbs, substantially increase effect of former material.Meanwhile, the similar Chinese medicine processing of decomposition of biological transformation system, decomposes noxious substance, thus reduces toxic and side effects, reduces the zest to skin.Edible fungus living being transforms and solves a large amount of with an organic solvent caused residual and pollution problem in extraction of traditional Chinese medicine, safer environmental protection.
Edible fungus fermented is that the biology carried out under the comparatively gentle condition such as room temperature, normal pressure transforms, and functional component in former material can be protected to greatest extent not to be destroyed, particularly to the protection of heat sensitivity material.
The invention provides a kind of fermented product composition improving skin problem, said composition raw material is made up of CFTE culture medium and ETS fermented product seed liquor;
In described composition material, ETS fermented product seed liquor and CFTE Medium Proportion ratio are that original material amount compares 20%-30%.
Edible fungi be selected from Auricularia, Tremella, Coprinus comatus, Hericium erinaceus (Bull. Ex Fr.) Pers., Lentinus Edodes, Agaricus blazei Murrill, BUZHIJUN powder, Cordyceps one or more, preferred BUZHIJUN powder and Lentinus Edodes or Agaricus blazei Murrill, excellent quality proportioning is the mixture of 1:1.5 composition.
Chinese herbal medicine is selected from one or more in Radix Glycyrrhizae, Herba Portulacae, Rhizoma Chuanxiong, Aloe vulgaris, Radix Angelicae Sinensis, Herba Saussureae Involueratae, Radix Ginseng, Flos Rosae Rugosae, Semen Sesami Nigrum, Folium Perillae, propolis, Testa oryzae, Herba Menthae, moringa seeds, Radix Paeoniae, Flos Carthami, the Radix Astragali, Fructus Forsythiae, Flos Chrysanthemi, Radix Saposhnikoviae, Herba Cichorii, Borneolum Syntheticum, Radix Arnebiae (Radix Lithospermi), Flos Matricariae chamomillae, Semen sojae atricolor, Porphyridium cruentum, Flos Caryophylli Radix et Caulis Opuntiae Dillenii, preferably, described Chinese herbal medicine is the mixture that 3:1:1 forms by Aloe vulgaris, Radix Ginseng, the excellent proportioning mass ratio of moringa seeds.
Described fruit, is preferably the fruit containing polyphenol, as blue berry, Fructus Mali pumilae, Fructus Citri grandis, Fructus Vitis viniferae, candleberry fruit etc.
Described Folium Camelliae sinensis is selected from: one or more in black tea, green tea, Ramulus et Folium Mussaendae Pubescentis, Folium Camelliae sinensis, postfermented tea, yellow tea, and preferably, described Folium Camelliae sinensis is by green tea and black tea, and excellent proportioning mass ratio is the mixture of 2:1 composition.
CFTE fermentation medium provided by the present invention, is characterized in that, comprises the former material component of following masses ratio:
Described CFTE fermentation medium is prepared through following method:
1) the former material of CFTE fermentation medium is taken according to following masses ratio:
2) Radix Ginseng, moringa seeds, Folium Camelliae sinensis, BUZHIJUN powder, Lentinus Edodes or the Agaricus blazei Murrill that will weigh up, micronizing, the grain diameter after pulverizing is no more than 120 μm; Aloe vulgaris, fruit containing polyphenol are through squeezing centrifuging and taking supernatant mucus; Above-mentioned mixing of materials after treatment also stirs, and makes CFTE fermentation medium.
Described Radix Ginseng is Changbai Mountain Radix Ginseng; Described moringa seeds is commercially available wing seed moringa seeds; Described Lentinus Edodes or Agaricus blazei Murrill are commercially available dry cap; Described Aloe vulgaris is 3 years fresh Aloe Barbadensis Millers; Described fruit is commercially available containing polyphenol fruit.
ETS fermented product seed liquor provided by the invention, is characterized in that, comprises the former material component of following masses ratio:
Described ETS fermented product seed liquor is prepared through following method:
1) former material is taken by following mass ratio:
2) by former for above-mentioned quality proportioning material micronizing, the grain diameter after pulverizing is no more than 120 μm, mix homogeneously, adds water and makes the ratio of compound and water be 1:2 mass ratio;
3) above-mentioned compound is loaded in fermentation tank at 30 ~ 40 DEG C, cultivates 35 ~ 55 hours in the cool, in material, grow fungal mycelia block;
4) centrifugal, first step fermentation liquid is collected cold preservation and deposits;
5) mycelia block is collected, and by mycelia block: the mass ratio of water=1:3 ~ 5, after being mixed by mycelia block, obtains fermented product seed liquor with water.
Described BUZHIJUN powder is commercially available prod, and described Semen sojae atricolor is commercially available Non-transgenic soybean, black tea, green tea commercially available prod in described Folium Camelliae sinensis, and described Lentinus Edodes or Agaricus blazei Murrill are commercially available dry cap.
Fermentor cultivation:
The culture medium prepared loaded in fermentation tank, then seed liquor is inoculated into fermentation cylinder for fermentation and cultivates, fermentation is under temperature is 23-28 DEG C of conditions, and fermentation period is 20-25 days.
The process of function ingredients:
After fermentation culture terminates, mix by the fermented product obtained with first step fermentation liquid, ultrasonic grinding, centrifugal, get supernatant warp and concentrate, spraying dry, makes fermented product composition.
Present invention also offers the cosmetics made containing above-mentioned fermented product composition or fermented product composition and adjuvant, described cosmetics can be one or more in cream frost, emulsion, water preparation, essence, facial film, cleansing milk, powder for soft mask, eye mask etc.
Described adjuvant can be one or more in the materials such as emulsifying agent, thickening agent, oils and fats, solvent, surfactant, other skin conditioning agents, essence, antiseptic.
Emulsifying agent can be the combination of glyceryl stearate, Polyethylene Glycol (100) stearate.
Thickening agent can be carbomer, carrageenan, HANSHENGJIAO.
Oils and fats can be Jojoba oil, squalane, Semen pruni armeniacae oil.
Skin conditioning agent can be hyaluronic acid, natto gum, amino acid humectant, hyaluronic acid, sodium lactate, pyrrolidone sodium carboxylate and D-panthenol.
Solvent can be propylene glycol, butanediol, water etc.
Except above-mentioned about the technical scheme of fermented product composition and cosmetic product, present invention also offers the technical scheme applied in cosmetics about fermented product composition.
Cosmetics provided by the invention, in antioxidation, antiinflammatory, irritation, anti-acne, releive, promote that local slightly damaged skin recovers, reduce skin injury recover after spot formed, and have the effects such as excellent crease-resistant, whitening, moisturizing, bright color; Use comfortable safety, non-stimulated to skin.
Fermented product composition selection of the present invention is particular about, proportioning is unique, technological innovation, safety, effectively, use comfortable, easy to utilize.
Can be further understood by following test experiments about advantage of the present invention.
Security performance is tested
This method of testing, defer to the method that country's " cosmetics health specification " 2007 editions tests about human safety, this detection method detects tested material (finished product and the raw material thereof) Potential feasibility to human body skin untoward reaction, and then gentle performance and the security performance of product are weighed in scoring.Concrete steps are as follows:
(1) select qualified volunteer, 18 ~ 60 years old age experimenter, the volunteer meeting the test requirements document of cosmetics health specification as study subject, volunteer's number of participating in the experiment: 45 people.
(2) method: skin closure patch test.
(3) given the test agent and process: No. 1 given the test agent is fermented product composition, No. 2 given the test agent are commercially available extractive composition, are mixed with 30% aqueous solution respectively; No. 3 samples are that distilled water is as blank.
(4) buy commercially available speckle examination device, tested material drips respectively and on the filter paper appended by speckle examination device, is placed in the corresponding speckle examination little indoor of device, consumption 0.025ml.The non-stimulated tape sticker of speckle examination device being added with tested material is spread on the bent side of forearm of experimenter, gently press with palm and make it to stick equably on skin, continue 24h.After removing tested material speckle examination device 30min, after impression disappears, observe dermoreaction.Separately observe again once after patch test 48h.Reaction result is recorded by table 1 (skin adverse reaction grade scale table) in " cosmetics health specification " 2007 editions.
Log: 45 people No. 1 sample tests participating in this time test is all 0 order reaction, and show that this fermentation composition does not cause untoward reaction to human body skin, safety is high, nonirritant; No. 2 sample tests have 2 people to have erythematous response result to be 2 grades, and 2 people have suspicious reaction (faint erythema) result to be 1 grade, show that this extractive composition has potentiality untoward reaction probability; No. 3 sample tests are all 0 order reaction.
Percutaneous permeability is evaluated
The effect of active ingredient of Chinese herbs transdermal delivery, very important as playing effectiveness of functional component in medicine for external use and cosmetics for it, for the skin Absorption Study of functional component, object may enter the qualitative of human body skin or quantitative information to obtain cosmetic composition under normal usage.This method of testing adopts the experiment of Franz diffusion cell Transdermal absorption, by the transdermal concentration of polysaccharide in phend-sulphuric acid detection composition, compares the Cutaneous permeation effect of fermented product composition and commercially available extractive composition.
Experiment is divided into 4 groups (namely each point is by 4 groups of data calculating mean values), and diluent is respectively 0.1%, and 0.5%, 1.0%, 5% sample solution, receiving liquid is normal saline.Experiment design temperature is (37 ± 0.5) DEG C, and acceptance pool mixing speed is 200rmin
-1, diffusion area is 7.1595cm
2.Sample permeates l, samples during 2,4,6,8,10,12h respectively, supplements equivalent acceptable solution to acceptance pool simultaneously.Phend-sulphuric acid detects sample concentration in acceptable solution.According to formulae discovery Percutaneous permeability Q (mgcm
-2), and drawing accumulative infiltration capacity (Q) and the transdermal penetration curve of time (t), the Percutaneous permeability Q of penetration curve afterbody straight line portion is carried out linear regression to time t, and gained straight slope is seepage velocity J (mghcm
-2), the results are shown in Table 1, table 2.
In formula, Q is Percutaneous permeability, and S is transdermal diffusion area, V
1for Franz diffusion cell acceptable solution volume (V
1=12.0mL), ρ
nbe the mass concentration (gL-1) of acceptable solution during the n-th sub-sampling, the mass concentration (gL-1) of acceptable solution when ρ i is the i-th sub-sampling, V
2for sampling amount (V
2=0.6mL).Do parallel test contrast fermented product composition and commercially available extractive composition transdermal effect under the same conditions.
Table 1 variable concentrations fermented product composition dermal penetration rate and accumulative infiltration capacity (x ± s, n=4)
Table 2 variable concentrations commercially available extractive composition dermal penetration rate and accumulative infiltration capacity (x ± s, n=4)
Illustrate that in compositions, polysaccharide concentration has impact to its percutaneous rate and accumulative infiltration capacity by above experimental data, composition levels is infiltration rate and accumulative infiltration capacity 0.1% ~ 5.0% time, the corresponding increase of the increase with its concentration; And fermented product composition is compared with commercially available extractive composition, fermented product composition infiltration rate and accumulative infiltration capacity are obviously better than commercially available extractive composition, thus prove fermented product composition and skin-friendliness better, permeability is stronger.
Antiinflammatory, detumescence, the test of promotion wound healing effect
Laboratory animal: get the healthy adult male rabbit of 30 body weight 2.0-2.2kg, after 1% pentobarbital sodium anesthesia, shave off the back rabbit hair, conventional transdermal is sterilized, both sides, back are cut the long stringer otch of a 2cm respectively and are cut skin, and the degree of depth reaches subcutaneous layer of fat, then sews up, operation was designated as postoperative 0th day the same day, by that analogy.
Experiment is divided into 3 groups, often organizes 10, and first group postoperative repeatedly smears 10% fermented product composition aqueous solution.Second group postoperative repeatedly smears 10% commercially available extractive composition aqueous solution, and the 3rd group of postoperative normal saline of repeatedly smearing is blank control sample.On the postoperative same day, smear 500 μ L samples every day, experimental period is 28 days.
Wound healing is observed: observe otch situation of change every day.Observe the response to traume of wound and perienchyma thereof in the 3rd day for each group, within the 7th, 14 day, observe wound recovery situation, within the 28th day, observe wound cicatrix situation.
The response to traume evaluation of wound and surrounding tissue thereof: 1. the I phase reacts, and wound has mild swelling; 2. the II phase reacts, wound and surrounding tissue Mild edema.3. the III phase reacts, and otch has a small amount of blood crusts to adhere to, wound and the obvious edema of surrounding tissue.
Wound recovery situation is evaluated: 1. excellent, wound tissue is without swelling.2. good, wound and surrounding tissue mild swelling.3. poor, wound and surrounding tissue swelling.
The observed result of rabbit postoperative wound healing: matched group majority had blood crusts to adhere in postoperative 3rd day, wound and the obvious edema of surrounding tissue; Commercially available extractive composition group, Sanguis Leporis seu oryctolagi crust degree alleviates, and edema degree alleviates; Fermented product composition group Sanguis Leporis seu oryctolagi crust degree obviously alleviates, and the edema degree of wound obviously alleviates (table 1).Postoperative 7th day and the 14th day (table 2), fermented product composition group rabbit wound healing is significantly better than commercially available extractive composition group, within postoperative 28th day, observe display, fermented product composition and commercially available extractive composition have the formation promoting wound granulation tissue and epithelial tissue, reduce wound contraction, contribute to the effect reducing cicatrization.Fermented product composition effect is better than commercially available extractive composition.
Table 1 is group wound response to traume situation comparative example (%) respectively
Table 2 is group wound recovery situation comparative example (%) respectively
Shown by above-mentioned experiment: fermented product composition antiinflammatory, detumescence successful, and have and promote wound healing significantly, reduce the effect of the formation of scar tissue.
Detailed description of the invention
In order to those skilled in the art can understand technical scheme of the present invention better, provide following specific embodiment, but these embodiments do not limit the scope of the invention.
Embodiment 1: crease-resistant facial film preparation of compacting
CFTE medium preparing:
1) take Radix Ginseng 160g, moringa seeds 160g, black tea 40g green tea 80g, BUZHIJUN powder 80g, Lentinus Edodes 120g, Fructus Citri grandis skin 100g micronizing, the grain diameter after pulverizing is no more than 120 μm;
2) Aloe Barbadensis Miller 480g, Fructus Vitis viniferae 100g is taken, squeezing, centrifuging and taking supernatant mucus;
3) above-mentioned mixing of materials after treatment stirring, makes fermentation medium.
Prepared by ETS fermented product seed liquor:
1) raw material is taken: BUZHIJUN powder 10g, Lentinus Edodes 15g, Semen sojae atricolor 10g, green tea 10g, black tea 5g;
2) by above-mentioned raw materials micronizing, after pulverizing, grain diameter is no more than 120 μm, mix homogeneously, and add water 100g;
3) above-mentioned compound is cultivated 45 hours at 35 DEG C;
4) centrifugal, first step fermentation liquid is collected cold preservation and deposits;
5) mycelia block is collected, mycelia block: the mass ratio of water=1:4, after length being had fungal mycelia block to mix with water, and obtained fermented product seed liquor.
Fermentor cultivation: the culture medium prepared loads fermentation tank, is then inoculated into fermentation cylinder for fermentation and cultivates, fermentation temperature 27 DEG C, 23 days cycles by seed liquor.
The process of function ingredients: after fermentation culture terminates, mix the fermented product obtained with first step fermentation liquid, ultrasonic grinding, centrifugal, gets supernatant, and warp concentrates, and spraying dry, makes fermented product composition.
[formula] (mass percent is as follows):
[method for making]
Xanthan gum is taken by formula, dissolve with glycerol, under agitation add Pyrusussuriensis (sugar) alcohol, propylene glycol, β-glucose, amino acid humectant, fermented product composition, tocopherol acetas, sturgeon roe beans extract, allantoin, xanthan gum successively, fully stir and make to dissolve completely, mixing, finally supply formula total amount with distilled water, adjust pH to 5.5 ~ 6.5, aseptic filtration, is sub-packed in and includes in non-woven bag, tight sealing, obtains the crease-resistant facial film finished product that compacts.
Embodiment 2 moistens moisture saver mask preparation
The preparation of ETS fermented product seed liquor is with embodiment 1.
Prepared by CFTE fermentation medium:
1) take Radix Ginseng 160g, moringa seeds 160g, black tea 40g green tea 80g, BUZHIJUN powder 80g, Lentinus Edodes 120g, Fructus Citri grandis skin 100g micronizing, the grain diameter after pulverizing is no more than 120 μm;
2) Aloe Barbadensis Miller 480g, candleberry fruit 100g is taken, squeezing, centrifuging and taking supernatant mucus;
3) above-mentioned mixing of materials after treatment stirring, makes fermentation medium.
Fermentation culture: the culture medium prepared loads fermentation tank, is then inoculated into fermentation cylinder for fermentation and cultivates, fermentation temperature 27 DEG C, 23 days cycles by seed liquor.
The process of function ingredients: after fermentation culture terminates, mix the fermented product obtained with first step fermentation liquid, ultrasonic grinding, centrifugal, gets supernatant, and warp concentrates, and spraying dry, makes fermented product composition.
[formula] (mass percent is as follows):
[method for making]
Take xanthan gum glycerol by formula to dissolve.Under agitation add Pyrusussuriensis (sugar) alcohol, propylene glycol, amino acid humectant, tocopherol acetas, fermented product composition, hyaluronate sodium, hydrolysis hyaluronic acid, allantoin, xanthan gum successively, abundant stirring makes to dissolve completely, mixing, finally supply formula total amount with distilled water, pH is adjusted to 5.5 ~ 6.5, aseptic filtration, is sub-packed in and includes in non-woven bag, tight sealing, obtains moist moisture saver mask finished product.
The careful pore facial film preparation of embodiment 3 antiallergic maintenance
The preparation of ETS (edible fungi, Folium Camelliae sinensis, Semen sojae atricolor) fermented product seed liquor is with embodiment 1.
Prepared by CFTE fermentation medium:
1) take Radix Ginseng 160g, moringa seeds 160g, black tea 40g green tea 80g, BUZHIJUN powder 80g, Lentinus Edodes 120g, Fructus Citri grandis skin 100g micronizing, the grain diameter after pulverizing is no more than 120 μm;
2) Aloe Barbadensis Miller 480g, Apples 100g is taken, squeezing, centrifuging and taking supernatant mucus;
3) above-mentioned mixing of materials after treatment stirring, makes fermentation medium.
Fermentation culture: the culture medium prepared loads fermentation tank, is then inoculated into fermentation cylinder for fermentation and cultivates, fermentation temperature 27 DEG C, 23 days cycles by seed liquor.
The process of function ingredients: after fermentation culture terminates, mix the fermented product obtained with first step fermentation liquid, ultrasonic grinding, centrifugal, gets supernatant, and warp concentrates, and spraying dry, makes fermented product composition.
[formula] (mass percent is as follows):
[method for making]
Take xanthan gum glycerol by formula to dissolve, under agitation add Pyrusussuriensis (sugar) alcohol, propylene glycol, amino acid humectant, fermented product composition, Herba portulacae extract, Hamamelis virginiana extract, tocopherol acetas, allantoin successively, abundant stirring makes to dissolve completely, mixing, finally supply formula total amount with distilled water, pH is adjusted to 5.5 ~ 6.5, aseptic filtration, be sub-packed in and include in non-woven bag, tightly seal, obtain antiallergic maintenance careful pore facial film finished product.
The thin skin essence of embodiment 4 whitening
The preparation of ETS fermented product seed liquor, the preparation of CFTE fermentation medium are with embodiment 1.
Fermentation culture: the culture medium prepared loads fermentation tank, is then inoculated into fermentation cylinder for fermentation and cultivates, fermentation temperature 27 DEG C, 25 days cycles by seed liquor.
The process of function ingredients: after fermentation culture terminates, mix the fermented product obtained with first step fermentation liquid, ultrasonic grinding, centrifugal, gets supernatant, and warp concentrates, and spraying dry, makes fermented product composition.
[formula] (mass percent is as follows):
[method for making]
Take card ripple 941 by formula to dissolve with glycerol.Under agitation add hyaluronic acid, sodium lactate, pyrrolidone sodium carboxylate, D-panthenol, Jojoba oil successively, fully stir and make to dissolve completely, mixing, with pH to 5.5 ~ 6.5 of sodium hydrate regulator solution, finally supply formula total amount with distilled water, aseptic filtration, subpackage, is finished product essence.
Embodiment 5 is releived the soft water of moisturizing
The preparation of ETS fermented product seed liquor is with embodiment 1
The preparation of CFTE fermentation medium is with embodiment 2
Fermentation culture: the culture medium prepared loads fermentation tank, is then inoculated into fermentation cylinder for fermentation and cultivates, fermentation temperature 27 DEG C, 23 days cycles by seed liquor.
The process of function ingredients: after fermentation culture terminates, mix the fermented product obtained with first step fermentation liquid, ultrasonic grinding, centrifugal, gets supernatant, and warp concentrates, and spraying dry, makes fermented product composition.
[formula] (mass percent is as follows):
[method for making]
Hyaluronic acid, sodium lactate, pyrrolidone sodium carboxylate, D-panthenol, glycerol, Herba portulacae extract, Hamamelis virginiana extract, fermented product composition is taken by formula, stirring and evenly mixing, then supply distilled water to 100 to stir, pH is adjusted to 5.5 ~ 6.5, aseptic filtration, subpackage, the both soft water finished product of Erlotinib moisturizing.
Embodiment 6 anti-wrinkle cream
[formula] (mass percent is as follows):
[method for making]
First get appropriate cream base, according to formula by hyaluronic acid, sodium lactate, pyrrolidone sodium carboxylate, Jojoba oil, D-panthenol, glycerol, fermented product composition, Matrixyl, tetrapeptide, stir, again whole cream base is added, stir, pH is adjusted to 5.5 ~ 6.5, subpackage, both obtains anti-wrinkle cream finished product.
Embodiment 7 is full of moistens moisturizing facial milk cleanser
[formula] (mass percent is as follows):
[method for making]
First get appropriate soap base substrate, according to formula, amino acid surfactant, glycerol, sodium lactate, pyrrolidone sodium carboxylate, hyaluronic acid, D-panthenol, fermented product composition, essence are stirred, again whole soap base substrate is added, stir, pH is adjusted to 5.5 ~ 6.5, subpackage, both must be full of and moisten moisturizing facial milk cleanser finished product.
Embodiment 8:
This embodiment is that the present invention will be further described by specific implementation method and function assessment result of study.
Select the volunteer that the colour of skin is gloomy, daylight is tanned, skin lines is more, the problem skins such as condition susceptible easily appear in skin, age 25-50 year different skin quality female volunteers 440, male 40 people, is divided into 8 groups to try out above-mentioned cosmetics embodiment, life cycle 28 days.Wherein trial state is as follows:
1st group: select the age 30-50 year experimenter, left face tries out embodiment 1 (the crease-resistant facial film that compacts) 1 month, uses weekly twice, each use after tender, pale, fine and smooth, the wrinkle of the water that becomes of skin alleviate, sustainable 3 days of Water-saving effect; Use after a period of time, skin become compact, elasticity increases; Use procedure is comfortable, increases with the penetrating sense of rear skin; Effect is remarkable, has no any untoward reaction.
2nd group: select the age 25-35 year dry skin and mixed skin experimenter, the left face of trier tries out embodiment 2 (moistening moisture saver mask) 1 month, use twice weekly, each water using rear skin to become is tender, pale, fine and smooth, glossy, sustainable 3 days of Water-saving effect; Use comfortable, increase with the penetrating sense of rear skin; Use after a period of time, it is tender, soft and smooth, beautiful that skin becomes water, and dry stricture of vagina reduces; Effect is remarkable, has no any untoward reaction.Mixed skin experimenter, sensation uses comfortable, without glutinous soapy feeling, also reduces the original fuel-displaced phenomenon in T district, and skin becomes fine and smooth.
3rd group: select the age 25-38 year oily skin and sensitive skin experimenter, left face tries out embodiment 3 (the careful pore facial film of antiallergic maintenance) 1 month, use twice weekly, use comfortable, the glutinous soapy feeling of nothing, pore are careful, alleviate original fuel-displaced phenomenon, in use procedure, do not find any discomfort or stimulation.In use for some time, during haze weather, there is not skin irritation sticky feeling in the past in sensitivity skin, skin immunization power improves, maintenance Be very effective yet.
4th group: select the age 30-50 year experimenter, select skin spottiness, dark and gloomy, matt experimenter, left face tries out embodiment 4 (the soft water of moisturizing of releiving) 1 month, and every day is sooner or later each to be used once, uses comfortable, without glutinous soapy feeling; After using a period of time, pale, fine and smooth, smooth, the colour of skin that skin becomes also are revised, and skin seems healthy beautiful; Effect is remarkable, does not find any discomfort or stimulation.
5th group: the left face of experimenter tries out embodiment 5 (the soft water of moisturizing of releiving) 1 month, and once, immediate effect is fine, moisturizing for the every day of each use sooner or later; Use comfortable, skin absorbs fast, moisturizing effective; After using a period of time, skin beauty water is tender, soft and smooth, beautiful, and effect is remarkable.The impaired skin of stratum corneum barrier, after using a period of time, skin does not occur that aculea pain and fiber crops itch, intimately feel again; Improve skin immunization power, repairing effect of releiving is obvious.Have no any untoward reaction.
6th group: the left face of experimenter tries out embodiment 6 (anti-wrinkle cream) 1 month, during this period, dry skin trier feels that product is fine and smooth, moist, water conservation, and wrinkle alleviates, and use sense is good; In, oily skin trier feels product non-greasy, good permeability, use sense is good.Use after a period of time, skin become compact, elasticity increases, Be very effective.
7th group: the left face of experimenter tries out embodiment 7 (be full of and moisten moisturizing facial milk cleanser) 1 month, and easily rinse when washing, wash rear skin not tight, skin silk is sliding.Skin that is dry after using a period of time, pruritus improves, without any zest.
8th group: do contrast test, in embodiment 2 (moistening moisture saver mask) formula, the commercially available extract equal volume of fermented product composition substitutes; The 2nd group of right face comparative sample of experimenter, trial effect is obviously not as left face.
Experimenter 480 people, through a course for the treatment of (28 days) trial edition invention product, wherein 436 people's significant effective, 35 people are improved, but effect is not obvious especially, and wherein 9 application on human skin improve DeGrain, but do not have 1 routine irritant reaction.Skin improves effective percentage and reaches more than 98%.
Following typical case
Case 1:
XXX, female, 33 years old, dry skin, Exposure to Sunlight caused skin erythema, and use 3 liang of weeks of embodiment continuously, skin is complete
Case 2
XXX, female, 28 years old, after mosquito bite, use embodiment 3 facial mask liquid to be applied in red and swollen place, immediately antipruritic, redness was improved very soon.
Case 3
XXX, female, 45 years old, dry skin, skin sensitivity, often occur phenomenon of casting off a skin, wrinkle is obvious, uses embodiment 3, continuously with 1 month, uses 3 times weekly, every day also coordinates embodiment 6 anti-wrinkle cream to use, and sooner or later respectively once, immediate effect is fine, and moisturizing, does not occur skin effect phenomenon again; Use after a period of time, it is tender, soft and smooth, beautiful that skin becomes water, and microgroove disappears, and dark stricture of vagina shoals, and effect is remarkable.
Case 4
XXX, female, 25 years old, oily skin, responsive body constitution, face head's small pox is serious, and rear face redness smeared by the anti-acne ointment of hospital's preparation, embodiment 3 facial mask liquid point is used to be applied to small pox place, after 5 hours, namely the small pox of enlargement has the phenomenon of detumescence, and after using 3 days continuously, small pox disappears substantially, and within follow-up several days, whole face is smeared, small pox does not occur again, uses continuously 1 month new pox print to disappear.
Case 5
XXX, female, 41 years old, skin had chloasma, the gloomy tarnish of the colour of skin and the time longer, reconstitute 1 little spoon (2g) fermented product composition with water before sleeping every day oral, daytime is carried out sun-proof, after 30 days, chloasma subtracts light, and face skin becomes pale, fine and smooth, children is sliding glossy.
Contrast test is done in embodiment 9 and commercial like product
The right face of trier that embodiment 8 proof test is the 1st, 3,4,5,6,7 groups tries out commercially available same dosage form congenerous Korea S brand product astringent, facial cream, facial milk cleanser and facial film 1 month respectively, carries out with left face is on probation simultaneously.Comparing result commercially available brand product indices is starkly lower than same dosage form of the present invention and declares product with effect.
Therefore fermented product composition of the present invention has good antioxidation, irritation, crease-resistant, antiinflammatory, whitening, anti-acne, releives, promotes that local slightly damaged skin recovers, reduce skin injury recover after spot form effect, can be used for preparing skin makeup article.
Embodiment is utilized to be illustrated to technical scheme of the present invention above; the detailed description of these embodiments is all to make those skilled in the art have comparatively distinct understanding to technical scheme of the present invention, can not be used for limiting protection scope of the present invention.For a person skilled in the art, they can make retouching and improvement according to the general knowledge of oneself to technical scheme of the present invention, will be understood that these retouchings and improvement are contained within protection scope of the present invention.
Claims (7)
1. one kind has the fermented product composition improving skin problem, it is characterized in that, the raw material of this fermented product composition is made up of CFTE (Chinese herbal medicine, the fruit containing polyphenol, Folium Camelliae sinensis, edible fungi) culture medium and ETS (edible fungi, Folium Camelliae sinensis, Semen sojae atricolor) fermented product seed liquor, and ETS fermented product seed liquor and CFTE Medium Proportion ratio are that original material amount compares 20%-30%;
The preparation method of described CFTE fermentation medium is:
1) according to following masses ratio batching:
2) by broken to the Radix Ginseng, moringa seeds, Folium Camelliae sinensis, BUZHIJUN powder, Lentinus Edodes or the super-fine powder of agaricus brasiliensis that weigh up, grain diameter after pulverizing is no more than 120 μm, Aloe vulgaris, fruit containing polyphenol are through squeezing centrifuging and taking supernatant mucus, above-mentioned mixing of materials after treatment also stirs, and makes CFTE fermentation medium;
Described Chinese herbal medicine is the mixture that 3:1:1 forms by Aloe vulgaris, Radix Ginseng, moringa seeds according to mass ratio, and described fruit is the fruit containing Polyphenols, and described Folium Camelliae sinensis is the mixture that 2:1 forms by green tea and black tea according to mass ratio;
The preparation method of described ETS fermented product seed liquor is:
1) prepare burden by following mass ratio:
2) by above-mentioned raw materials micronizing, the grain diameter after pulverizing is no more than 120 μm, mix homogeneously, adds water and makes the ratio of compound and water be 1:2 mass ratio;
3) by above-mentioned compound at 30 ~ 40 DEG C, cultivate 35 ~ 55 hours;
4) centrifugal, first step fermentation liquid is collected cold preservation and deposits;
5) mycelia block is collected, mycelia block: the mass ratio of water=1:3 ~ 5, after having the mycelia block of fungus to mix with water length, obtains fermented product seed liquor;
Ferment tank is cultivated: the culture medium prepared loaded in fermentation tank, then seed liquor be inoculated in fermentation tank and cultivate, fermentation is that fermentation period is 20-25 days under temperature is 23 DEG C of-28 DEG C of conditions;
The process of function ingredients: after fermentation culture terminates, mix the fermented product obtained with first step fermentation liquid, ultrasonic grinding, centrifugal, and get supernatant warp and concentrate, spraying dry, makes fermented product composition.
Described ETS fermented product seed liquor is made up of BUZHIJUN powder, Lentinus Edodes or Agaricus blazei Murrill, Semen sojae atricolor, Folium Camelliae sinensis mixture, and described Folium Camelliae sinensis is the mixture that 2:1 forms by green tea and black tea according to mass ratio.
2. fermented product composition according to claim 1, is characterized in that, described Chinese herbal medicine is the mixture that 3:1:1 forms by Aloe vulgaris, Radix Ginseng, moringa seeds according to mass ratio.
3. fermented product composition according to claim 1, is characterized in that, described fruit, is preferably the fruit containing Polyphenols, as blue berry, Fructus Mali pumilae, Fructus Citri grandis, Fructus Vitis viniferae, candleberry fruit etc.
4. fermented product composition according to claim 1, is characterized in that, described edible fungi is mixture that 1:1.5 forms by BUZHIJUN powder and Lentinus Edodes or Agaricus blazei Murrill in mass ratio.
5. fermented product composition according to claim 1, is characterized in that, described Folium Camelliae sinensis is the mixture that 2:1 forms by green tea and black tea according to mass ratio.
6. containing the cosmetics that fermented product composition described in any one of claim 1-5 or fermented product composition and adjuvant are made, it is characterized in that, described cosmetics can be one or more in cream frost, emulsion, water preparation, essence, facial film, cleansing milk, powder for soft mask, eye sticker etc.; Described adjuvant can be emulsifying agent, thickening agent, oils and fats, solvent, surfactant, other skin conditioning agents, essence, antiseptic, etc. one or more in material.
7. the fermented product composition according to any one of claim 1-5 or cosmetics according to claim 6 have good antioxidation, antiinflammatory, irritation, anti-acne, releive, promote that local slightly damaged skin recovers, reduce skin injury recover after spot formed, and have the effects such as excellent crease-resistant, whitening, moisturizing.
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| CN106236618A (en) * | 2016-07-18 | 2016-12-21 | 益盛汉参化妆品有限公司 | Cleaning products containing corn and Radix Ginseng fermented product and preparation method thereof |
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| CN106726885A (en) * | 2016-11-30 | 2017-05-31 | 佛山市芊茹化妆品有限公司 | A kind of grapefruit yogurt of skin softening and beautifying and its application in cosmetics |
| CN106860048A (en) * | 2017-02-24 | 2017-06-20 | 长沙协浩吉生物工程有限公司 | A kind of compound method of ferment anti-acne essence |
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| CN110025501A (en) * | 2019-05-13 | 2019-07-19 | 武汉森澜生物科技有限公司 | The composition and its preparation method and application to keep the skin wet for skin |
| CN110025501B (en) * | 2019-05-13 | 2022-01-18 | 武汉森澜生物科技有限公司 | Composition for supplementing moisture to skin and preparation method and application thereof |
| CN110522662A (en) * | 2019-08-29 | 2019-12-03 | 福州东星生物技术有限公司 | A kind of ganoderma lucidum face cream and preparation method thereof |
| CN110538116A (en) * | 2019-10-16 | 2019-12-06 | 湖南佰诺酒业有限公司 | Waxberry precious beautifying and skin-beautifying liquid |
| CN113144039A (en) * | 2020-10-21 | 2021-07-23 | 利施(上海)化妆品有限公司 | Plant anti-allergy relieving composition and preparation method and application thereof |
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Effective date of registration: 20220406 Address after: Room 202, No. 33, gongnongsi village, Yangpu District, Shanghai 200082 Patentee after: Qian Zhitao Address before: 065201 room 1003, unit 1, building 4, zhongxingheyuan, Yanshun Road, Yanjiao Economic and Technological Development Zone, Sanhe City, Langfang City, Hebei Province Patentee before: Song Chengyou |