CN110522662A - A kind of ganoderma lucidum face cream and preparation method thereof - Google Patents
A kind of ganoderma lucidum face cream and preparation method thereof Download PDFInfo
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
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Abstract
The present invention discloses a kind of ganoderma lucidum face cream comprising following component: Ganodenna Lucidum P.E, moisturizer, emulsifier, ginger extractive from fermentative, blueberry extractive from fermentative, microwax, saualane, water, the invention also discloses its production methods.Anti-aging of the present invention, it is crease-resistant, prevent and treat senile plaque, be not easy allergy, be hypo-allergenic.
Description
Technical field
The present invention relates to cosmetic technical fields more particularly to a kind of ganoderma lucidum face cream and preparation method thereof.
Background technique
Human senility is a kind of irreversible degradation phenomena occurred with age growth, can be divided into naturally-aged and disease declines
Always.
Facial aging is the main performance of human senility, including facial wrinkles, formation (the especially lower eyelid of upper lower eyelid blepharoplasty
Bag), the intensification of nasolabial groove, spot occurs and the variation etc. of facial skeleton especially jawbone.The wherein senile plaque pole in spot
Hardly possible is eliminated, once there is senile plaque, also can cause to hit in terms of the spirit to people, so how pre- anti-aging and removal is old
Spot is all very urgent problem.
How to delay senescence and slow down and injured by disease aging to mankind's bring, it has also become current field of medical biology
Research hotspot, and be increasingly subject to the concern of countries in the world.It is various anti-ageing as anti-aging product studies progress like a raging fire
Old drug also emerges in multitude market, and edible and medical fungi anti-aging product has become the new lover of research field at present, and numerous anti-
In aging product, the hot research to anti-aging is the research of skin care item.
Such as application No. is a kind of 201410219028.4 ganoderma lucidum anti-aging face creams, are comprising accounting for face cream mass percent
The ingredient B of the ingredient A and 0.02%-5% of 0.02-5%.A kind of preparation method of ganoderma lucidum anti-aging face cream is also disclosed, including
Prepared composition A, i.e. ganoderma lucidum water mention activity of fighting against senium ingredient；Prepared composition B, i.e. ganoderma lucidum CO2 supercritical extract activity of fighting against senium
Ingredient, by addition base-material obtains face cream after ingredient A and ingredient B high temperature emulsification according to a certain ratio and at high temperature.But this
Face cream is easy to allow user's allergy, and generating possible allergy for ganoderma lucidum, there is no any quick measures of drop, while this face cream is to old
There is no good removals to act on for year spot.
Summary of the invention
It is an object of the present invention to be directed to the above-mentioned deficiency of the prior art, propose that a kind of anti-aging, crease-resistant, prevention and treatment is old
Spot is not easy allergy, hypo-allergenic ganoderma lucidum face cream and preparation method thereof.
The present invention solves its technical problem, the technical solution adopted is that, propose a kind of ganoderma lucidum face cream comprising: following group
Point: Ganodenna Lucidum P.E, moisturizer, emulsifier, ginger extractive from fermentative, blueberry extractive from fermentative, microwax, saualane, water.
Ganoderma lucidum has crease-resistant, anti-inflammatory, removes color spot, protection skin.Ganoderma lucidum, which contains, inhibits the ingredient of melanin and a variety of right
The microelement etc. of skin beneficiating, these ingredients can accelerate the regeneration of cell, increase skin by reducing human free radical
Thickness simultaneously increases collagen, achievees the effect that plump skin, elimination microgroove and wrinkle, polysaccharide component therein can pass through holding
Skin is aqueous with adjusting, and restores skin elasticity, makes skin wet, exquisiteness.Saualane reinforces maintenance epidermis, is effectively formed natural guarantor
Cuticula helps the balance between skin and sebum.Saualane is a kind of lipid closest to human sebaceous, and affinity is strong, Neng Gouyu
The sebum film of mankind itself combines together, forms one layer of natural barrier in skin surface, moreover it is possible to inhibit the peroxide of skin lipid
Change, can effectively infiltrate through skin, and promote the proliferation of skin base cell, to delay skin aging, improve and eliminate chloasma
There is apparent physiologic effect, skin pore can be made to open, promotes blood microcirculation, promote the metabolism of cell, help to repair
Multiple breakage cell.Ganodenna Lucidum P.E can act synergistically with saualane, prevent the lipid accumulation of peroxidating from reducing on the skin
Ganoderma lucidum thickens the effect of skin, there are when the lipid of peroxidating, also will appear a kind of impermeable situation after pachyderma, so that
Skin is not fine and smooth enough, there is also the coarse situation of pore.Ginger has the function of except senile plaque, but directly allows the mentioning of ginger
Object is taken to be added in skin care item, it is easy to stimulation is generated to skin, influences the absorption of other compositions, it, can be with by fermenting to it
This problem is well solved, ginger extractive from fermentative is mild, mentions with Ganodenna Lucidum P.E and the fermentation of saualane and blueberry
Take object that can prevent and treat senile plaque well together.Anthocyanidin rich in in blueberry ensure that user is not easy allergy, long
It uses long, the antiallergic performance of skin can be made to improve.Ganoderma lucidum, saualane, ginger, blueberry all have anti-oxidant, elimination freely
The effect of base has the function that prevent and treat user's aging.
As a preferred embodiment of the above technical solution, the ganoderma lucidum face cream is prepared by comprising the following components in parts by weight: spirit
1-3 parts of sesame extract, 6-15 parts of moisturizer, 3-7 parts of emulsifier, 1-2 parts of ginger extractive from fermentative, blueberry extractive from fermentative 2-3
Part, 5-9 parts of microwax, 4-10 parts of saualane, 30-50 parts of water.
As a preferred embodiment of the above technical solution, the Ganodenna Lucidum P.E the preparation method is as follows: by weight being taken for 1-3:1
Ganoderma lucidum mycelium and Reishi sporule are pulverized to obtain to mixing after Reishi sporule progress broken wall treatment with ganoderma lucidum mycelium
Ultramicro-powder is carried out decompression boiling refluxing extraction 3-8h by Ultramicro-powder, and decompression makes water boil at 40-60 DEG C, water is obtained by filtration later
Pretreated feedstock is divided into two parts of equivalent by solution and pretreated feedstock, and a copy of it carries out supercritical carbon dioxide extracting work
Skill obtains product one, another carries out subcritical abstraction technique and obtains product two, and aqueous solution, product two are concentrated respectively, is spraying
It is dried to obtain concentration powder one, concentration powder two, the purification of product one is obtained into ganoderma oil, is taken later according to weight ratio for 1:3-5:1-2
Concentration powder one, ganoderma oil, concentration powder two are configured to Ganodenna Lucidum P.E.In order to reduce the possible sensitization rate of ganoderma lucidum, inventor's selection
Use ganoderma lucidum mycelium and Reishi sporule as the raw material for extracting Ganodenna Lucidum P.E, it, can by original Different Extraction Method
So that the ingredient of extract is complete, reach expected effect, at the same can according to effect, anti-sensitization, use feeling come into
Ratio of the substance that row allotment distinct methods extract in Ganodenna Lucidum P.E.
As a preferred embodiment of the above technical solution, the ginger extractive from fermentative, blueberry extractive from fermentative preparation method such as
Under: clean smash to pieces of ginger and blueberry is individually placed in two fermentors, glucose, white sand is added in two fermentors respectively
Sugar, water, lactic acid bacteria, saccharomycete, acetobacter carry out anaerobic fermentation, be obtained by filtration respectively later ginger fermentation liquid, ginger slag and
Blueberry fermentation liquid, blueberry residue sterilize respectively to ginger fermentation liquid and blueberry fermentation liquid, are concentrated, being spray-dried and obtain ginger
Extractive from fermentative, blueberry extractive from fermentative.
As a preferred embodiment of the above technical solution, the cultivation base when raw material cultivation of the Ganodenna Lucidum P.E includes following group
Point: stalk, ginger slag, blueberry residue, corn stigma, mulberry tree branch, lime, magnesium sulfate, cotton seed hulls, stone flower, gypsum, water.By ginger
Slag, blueberry residue as culture Ganodenna Lucidum P.E raw material culture medium component, can make the Ganodenna Lucidum P.E finally obtained with
Blueberry extractive from fermentative, ginger extractive from fermentative are more harmonious, so that the smell harmony of last ganoderma lucidum face cream, use feeling are more
Well, effect is more preferable, while can reduce the sensitization rate of face cream；Also it is capable of the pollution of save the cost, reduction environment simultaneously.
As a preferred embodiment of the above technical solution, the culture medium is prepared by comprising the following components in parts by weight: stalk
30-45 parts, 5-8 parts of ginger slag, 7-12 parts of blueberry residue, 5-9 parts of corn stigma, mulberry tree branch 25-38 parts, 0.5-1.5 parts of lime, sulfuric acid
0.7-1.2 parts of magnesium, 20-32 parts of cotton seed hulls, 3-5 parts of stone flower, 1-3 parts of gypsum, 70-100 parts of water.
As a preferred embodiment of the above technical solution, the culture medium the preparation method is as follows:
(1), stalk, corn stigma, mulberry tree branch, stone flower, 1/3-2/3 ginger slag, 1/4-1/2 blueberry residue and water are stirred first equal
It is even, material heap one is piled, covers fermentation 20-28h with plastic film；
(2), remaining ginger slag, blueberry residue, lime, magnesium sulfate, cotton seed hulls, gypsum is added into material heap one later, stirring is equal
It is even to pile material heap two again, and continue the 12-20h that ferments with plastic film covering；
(3), it is sterilized the material in material heap two to obtain culture medium.
As a preferred embodiment of the above technical solution, it in step (2), needs first low to moisture content to ginger slag and blueberry residue drying
In 5%, it is pulverized to obtain Ultramicro-powder later.
As a preferred embodiment of the above technical solution, the moisturizer includes butanediol, Natrulon H-10, glycerol, Sodium Hyaluronate
One of or it is a variety of.
As a preferred embodiment of the above technical solution, the emulsifier includes cetearyl glucoside, octyldodecanol, palm fibre
One of palmitic acid alcohol is a variety of.
Another object of the present invention is to propose a kind of preparation method of ganoderma lucidum face cream, is included the following steps: moisturizer
It is stirred at 55-80 DEG C with ginger extractive from fermentative to being completely dissolved, microwax is added and Ganodenna Lucidum P.E continues to stir
1-3h is cooled to 35-45 DEG C while stirring later, and blueberry extractive from fermentative, emulsifier and water ultrasound 80-150min is added, it
Saualane is added afterwards to be uniformly mixed to obtain ganoderma lucidum face cream.
As a preferred embodiment of the above technical solution, the Ganodenna Lucidum P.E before addition, is first ultrasonically treated 10- to it
20min。
The present invention by implementing the obtained ganoderma lucidum face cream of above-mentioned technical proposal, have anti-aging, crease-resistant, prevention and treatment senile plaque,
It is not easy allergy, hypo-allergenic effect, while the smell of face cream is harmonious, use feeling is good.
Specific embodiment
The following is specific embodiments of the present invention, and technical scheme of the present invention will be further described, but the present invention is simultaneously
It is not limited to these embodiments.
Embodiment 1:
A kind of ganoderma lucidum face cream, is prepared by comprising the following components in parts by weight: 2 parts of Ganodenna Lucidum P.E, 5 parts of moisturizer, emulsification
4 parts of agent, 1 part of ginger extractive from fermentative, 3 parts of blueberry extractive from fermentative, 6 parts of microwax, 8 parts of saualane, 45 parts of water.Wherein moisturizing
The mixture of Natrulon H-10, glycerol is selected in agent, and emulsifier selects the mixture of octyldodecanol, palmityl alcohol.
The Ganodenna Lucidum P.E the preparation method is as follows: by weight ganoderma lucidum mycelium and Reishi sporule is taken for 2:1, to spirit
It is mixed after Ganoderma lucidum spore progress broken wall treatment with ganoderma lucidum mycelium and is pulverized to obtain Ultramicro-powder, Ultramicro-powder is subjected to decompression water
Refluxing extraction 8h is boiled, decompression makes water boil at 40-60 DEG C, aqueous solution and pretreated feedstock are obtained by filtration later, and pretreatment is former
Material is divided into two parts of equivalent, and a copy of it carries out supercritical CO 2 extraction technology and obtains product one, another carries out Asia and faces
Boundary's extraction process obtains product two, aqueous solution, product two are concentrated respectively, be spray-dried obtain concentration powder one, concentration powder two, will
The purification of product one obtains ganoderma oil, is later that 1:3:1 takes concentration powder one, ganoderma oil, concentration powder two to be configured to spirit according to weight ratio
Sesame extract.
The ginger extractive from fermentative, blueberry extractive from fermentative are smashed to pieces the preparation method is as follows: ginger and blueberry are cleaned
It is individually placed in two fermentors, glucose, white granulated sugar, water, lactic acid bacteria, saccharomycete, vinegar is added in two fermentors respectively
Acidfast bacilli carries out anaerobic fermentation, ginger fermentation liquid, ginger slag and blueberry fermentation liquid, blueberry residue is obtained by filtration respectively later, to life
Ginger fermentation liquid and blueberry fermentation liquid sterilized respectively, be concentrated, be spray-dried obtain ginger extractive from fermentative, blueberry fermentation is extracted
Object.
A kind of preparation method of ganoderma lucidum face cream includes the following steps: moisturizer and ginger extractive from fermentative at 80 DEG C
It is stirred to being completely dissolved, (Ganodenna Lucidum P.E before addition, is first ultrasonically treated it for addition microwax and Ganodenna Lucidum P.E
10min) continue to stir 1h, be cooled to 35 DEG C while stirring later, blueberry extractive from fermentative, emulsifier and water ultrasound is added
Saualane is added later and is uniformly mixed to obtain ganoderma lucidum face cream by 120min.
Embodiment 2:
A kind of ganoderma lucidum face cream, is prepared by comprising the following components in parts by weight: 3 parts of Ganodenna Lucidum P.E, 6 parts of moisturizer, emulsification
5 parts of agent, 1 part of ginger extractive from fermentative, 3 parts of blueberry extractive from fermentative, 7 parts of microwax, 7 parts of saualane, 30 parts of water.Wherein moisturizing
The mixture of Natrulon H-10, glycerol is selected in agent, and emulsifier selects the mixture of octyldodecanol, palmityl alcohol.
The Ganodenna Lucidum P.E the preparation method is as follows: by weight ganoderma lucidum mycelium and Reishi sporule is taken for 2:1, to spirit
It is mixed after Ganoderma lucidum spore progress broken wall treatment with ganoderma lucidum mycelium and is pulverized to obtain Ultramicro-powder, Ultramicro-powder is subjected to decompression water
Refluxing extraction 8h is boiled, decompression makes water boil at 40-60 DEG C, aqueous solution and pretreated feedstock are obtained by filtration later, and pretreatment is former
Material is divided into two parts of equivalent, and a copy of it carries out supercritical CO 2 extraction technology and obtains product one, another carries out Asia and faces
Boundary's extraction process obtains product two, aqueous solution, product two are concentrated respectively, be spray-dried obtain concentration powder one, concentration powder two, will
The purification of product one obtains ganoderma oil, is later that 1:3:2 takes concentration powder one, ganoderma oil, concentration powder two to be configured to spirit according to weight ratio
Sesame extract.
The ginger extractive from fermentative, blueberry extractive from fermentative are smashed to pieces the preparation method is as follows: ginger and blueberry are cleaned
It is individually placed in two fermentors, glucose, white granulated sugar, water, lactic acid bacteria, saccharomycete, vinegar is added in two fermentors respectively
Acidfast bacilli carries out anaerobic fermentation, ginger fermentation liquid, ginger slag and blueberry fermentation liquid, blueberry residue is obtained by filtration respectively later, to life
Ginger fermentation liquid and blueberry fermentation liquid sterilized respectively, be concentrated, be spray-dried obtain ginger extractive from fermentative, blueberry fermentation is extracted
Object.
Culture medium when the raw material cultivation of the Ganodenna Lucidum P.E is prepared by comprising the following components in parts by weight: stalk
45 parts, 6 parts of ginger slag, 7 parts of blueberry residue, 9 parts of corn stigma, mulberry tree branch 31 parts, 1 part of lime, 0.7 part of magnesium sulfate, 32 parts of cotton seed hulls,
3 parts of stone flower, 2 parts of gypsum, 85 parts of water.
The culture medium the preparation method is as follows:
(1), stalk, corn stigma, mulberry tree branch, stone flower, 2/3 ginger slag, 1/4 blueberry residue and water are stirred evenly first, is piled
Material heap one covers fermentation 28h with plastic film；
(2), dry to remaining ginger slag and blueberry residue to be lower than 5% to moisture content, it is pulverized to obtain ultra micro later
Powder, into material heap one be added Ultramicro-powder, lime, magnesium sulfate, cotton seed hulls, gypsum, stir evenly and pile material heap two again, and with mould
Material film covering continues the 16h that ferments；
(3), it is sterilized the material in material heap two to obtain culture medium.
A kind of preparation method of ganoderma lucidum face cream includes the following steps: moisturizer and ginger extractive from fermentative at 80 DEG C
It is stirred to being completely dissolved, (Ganodenna Lucidum P.E before addition, is first ultrasonically treated it for addition microwax and Ganodenna Lucidum P.E
20min) continue to stir 1h, be cooled to 40 DEG C while stirring later, blueberry extractive from fermentative, emulsifier and water ultrasound is added
Saualane is added later and is uniformly mixed to obtain ganoderma lucidum face cream by 150min.
Embodiment 3:
A kind of ganoderma lucidum face cream, is prepared by comprising the following components in parts by weight: 1 part of Ganodenna Lucidum P.E, 15 parts of moisturizer, emulsification
3 parts of agent, 1.5 parts of ginger extractive from fermentative, 2 parts of blueberry extractive from fermentative, 5 parts of microwax, 10 parts of saualane, 40 parts of water.Wherein
Moisturizer selects the mixture of butanediol, Natrulon H-10, glycerol, and emulsifier selects cetearyl glucoside, octyldodecyl
The mixture of alcohol.
The Ganodenna Lucidum P.E the preparation method is as follows: by weight ganoderma lucidum mycelium and Reishi sporule is taken for 3:1, to spirit
It is mixed after Ganoderma lucidum spore progress broken wall treatment with ganoderma lucidum mycelium and is pulverized to obtain Ultramicro-powder, Ultramicro-powder is subjected to decompression water
Refluxing extraction 3h is boiled, decompression makes water boil at 40-60 DEG C, aqueous solution and pretreated feedstock are obtained by filtration later, and pretreatment is former
Material is divided into two parts of equivalent, and a copy of it carries out supercritical CO 2 extraction technology and obtains product one, another carries out Asia and faces
Boundary's extraction process obtains product two, aqueous solution, product two are concentrated respectively, be spray-dried obtain concentration powder one, concentration powder two, will
The purification of product one obtains ganoderma oil, is later that 1:5:1 takes concentration powder one, ganoderma oil, concentration powder two to be configured to spirit according to weight ratio
Sesame extract.
The ginger extractive from fermentative, blueberry extractive from fermentative are smashed to pieces the preparation method is as follows: ginger and blueberry are cleaned
It is individually placed in two fermentors, glucose, white granulated sugar, water, lactic acid bacteria, saccharomycete, vinegar is added in two fermentors respectively
Acidfast bacilli carries out anaerobic fermentation, ginger fermentation liquid, ginger slag and blueberry fermentation liquid, blueberry residue is obtained by filtration respectively later, to life
Ginger fermentation liquid and blueberry fermentation liquid sterilized respectively, be concentrated, be spray-dried obtain ginger extractive from fermentative, blueberry fermentation is extracted
Object.
Culture medium when the raw material cultivation of the Ganodenna Lucidum P.E is prepared by comprising the following components in parts by weight: stalk
30 parts, 5 parts of ginger slag, 9 parts of blueberry residue, 5 parts of corn stigma, mulberry tree branch 25 parts, 0.5 part of lime, 1.2 parts of magnesium sulfate, cotton seed hulls 26
Part, 5 parts of stone flower, 1 part of gypsum, 100 parts of water.
The culture medium the preparation method is as follows:
(1), stalk, corn stigma, mulberry tree branch, stone flower, 1/3 ginger slag, 3/8 blueberry residue and water are stirred evenly first, is piled
Material heap one covers fermentation 20h with plastic film；
(2), dry to remaining ginger slag and blueberry residue to be lower than 5% to moisture content, it is pulverized to obtain ultra micro later
Powder, into material heap one be added Ultramicro-powder, lime, magnesium sulfate, cotton seed hulls, gypsum, stir evenly and pile material heap two again, and with mould
Material film covering continues the 12h that ferments；
(3), it is sterilized the material in material heap two to obtain culture medium.
A kind of preparation method of ganoderma lucidum face cream includes the following steps: moisturizer and ginger extractive from fermentative at 55 DEG C
It is stirred to being completely dissolved, (Ganodenna Lucidum P.E before addition, is first ultrasonically treated it for addition microwax and Ganodenna Lucidum P.E
10min) continue to stir 2h, be cooled to 35 DEG C while stirring later, blueberry extractive from fermentative, emulsifier and water ultrasound is added
Saualane is added later and is uniformly mixed to obtain ganoderma lucidum face cream by 115min.
Embodiment 4:
A kind of ganoderma lucidum face cream, is prepared by comprising the following components in parts by weight: 2 parts of Ganodenna Lucidum P.E, 10 parts of moisturizer, emulsification
7 parts of agent, 2 parts of ginger extractive from fermentative, 2.5 parts of blueberry extractive from fermentative, 9 parts of microwax, 4 parts of saualane, 50 parts of water.Wherein protect
Humectant select butanediol, Natrulon H-10, glycerol, Sodium Hyaluronate mixture, emulsifier select cetearyl glucoside,
The mixture of octyldodecanol, palmityl alcohol.
The Ganodenna Lucidum P.E the preparation method is as follows: by weight ganoderma lucidum mycelium and Reishi sporule is taken for 1:1, to spirit
It is mixed after Ganoderma lucidum spore progress broken wall treatment with ganoderma lucidum mycelium and is pulverized to obtain Ultramicro-powder, Ultramicro-powder is subjected to decompression water
Refluxing extraction 5h is boiled, decompression makes water boil at 40-60 DEG C, aqueous solution and pretreated feedstock are obtained by filtration later, and pretreatment is former
Material is divided into two parts of equivalent, and a copy of it carries out supercritical CO 2 extraction technology and obtains product one, another carries out Asia and faces
Boundary's extraction process obtains product two, aqueous solution, product two are concentrated respectively, be spray-dried obtain concentration powder one, concentration powder two, will
The purification of product one obtains ganoderma oil, is later that 1:5:2 takes concentration powder one, ganoderma oil, concentration powder two to be configured to spirit according to weight ratio
Sesame extract.
The ginger extractive from fermentative, blueberry extractive from fermentative are smashed to pieces the preparation method is as follows: ginger and blueberry are cleaned
It is individually placed in two fermentors, glucose, white granulated sugar, water, lactic acid bacteria, saccharomycete, vinegar is added in two fermentors respectively
Acidfast bacilli carries out anaerobic fermentation, ginger fermentation liquid, ginger slag and blueberry fermentation liquid, blueberry residue is obtained by filtration respectively later, to life
Ginger fermentation liquid and blueberry fermentation liquid sterilized respectively, be concentrated, be spray-dried obtain ginger extractive from fermentative, blueberry fermentation is extracted
Object.
Culture medium when the raw material cultivation of the Ganodenna Lucidum P.E is prepared by comprising the following components in parts by weight: stalk
37 parts, 8 parts of ginger slag, 12 parts of blueberry residue, 7 parts of corn stigma, mulberry tree branch 38 parts, 1.5 parts of lime, 0.9 part of magnesium sulfate, cotton seed hulls 20
Part, 4 parts of stone flower, 3 parts of gypsum, 70 parts of water.
The culture medium the preparation method is as follows:
(1), stalk, corn stigma, mulberry tree branch, stone flower, 1/2 ginger slag, 1/2 blueberry residue and water are stirred evenly first, is piled
Material heap one, for 24 hours with plastic film covering fermentation；
(2), dry to remaining ginger slag and blueberry residue to be lower than 5% to moisture content, it is pulverized to obtain ultra micro later
Powder, into material heap one be added Ultramicro-powder, lime, magnesium sulfate, cotton seed hulls, gypsum, stir evenly and pile material heap two again, and with mould
Material film covering continues the 20h that ferments；
(3), it is sterilized the material in material heap two to obtain culture medium.
A kind of preparation method of ganoderma lucidum face cream includes the following steps: moisturizer and ginger extractive from fermentative at 67 DEG C
It is stirred to being completely dissolved, (Ganodenna Lucidum P.E before addition, is first ultrasonically treated it for addition microwax and Ganodenna Lucidum P.E
15min) continue to stir 3h, be cooled to 45 DEG C while stirring later, blueberry extractive from fermentative, emulsifier and water ultrasound is added
Saualane is added later and is uniformly mixed to obtain ganoderma lucidum face cream by 80min.
Comparative example 1:
Difference from Example 1 is that ginger extractive from fermentative and blueberry extractive from fermentative are changed to Ginger P.E and blueberry
Extract.
Comparative example 2:
Difference from Example 1 is that the raw material of Ganodenna Lucidum P.E is ganoderma lucidum fruitbody, and lacks ginger extractive from fermentative.
Test 1, Product Safety evaluation (experiment of human skin patch)
One, trial target: the ganoderma lucidum face cream that embodiment 1-3, comparative example 1,2 are prepared
Tested crowd's number: 100 people, 50 women, 50 males
Age: 30-60 years old
Health status: without serious systemic disease, without immune deficiency or autoimmune disease person, no active anaphylactia
Person, previously to skin-care cosmetics without allergies, whole body does not use hormone medicine and immunosuppressor person in nearly January, not
Other clinical test persons are participated in, meets subject and volunteers inclusion criteria.
Grouping: 5 groups, every group of 10 female, 10 male, average age 45 ± 2 years old.
Two, patch method: qualified spot tester is selected, with closed patch experiment method, by tested material about 0.020g-
For 0.025g drop in spot tester, external application special adhesive tape is covered on subject back, and tested material is removed after 24 hours, after removing respectively
0.5, observation dermoreaction in 6,12,24,48 hours, records its knot according to dermoreaction grade scale in " cosmetics health specification "
Fruit.
Three, experimental result: human skin patch test result is shown: each group subject by embodiment 1-3, comparative example 1,
The patch test of 2 ganoderma lucidum face cream, in observation dermoreaction in 0.5,6,12,24,48 hour, wherein 0 skin occur bad anti-
It answers, it is safe to illustrate that the ganoderma lucidum face cream uses.
Test 2: product effect assessment
First part:
One, trial target: the ganoderma lucidum face cream that embodiment 1-3, comparative example 1-2 are prepared
Two, tested crowd
Gender number: each 25 people of every group of men and women, totally 5 groups
Age: between 30-60 years old, every group of average age 45 ± 2 years old.
Health status: without serious systemic disease, without immune deficiency or autoimmune disease person, no active anaphylaxis
Disease patient, previously to skin-care cosmetics without allergies, whole body does not use hormone medicine and immunosuppressor in nearly January
Person does not participate in other clinical test persons, meets subject and volunteers inclusion criteria.
Three, test method: using the skin elasticity of Courage+Khazaka company, Germany (German CK company) manufacture
CotometerMPA580 host, used probe are Reviscometer RV600 elastic fibrous tissue test probes,
It surveys five times and is averaged.Test zone: place between the eyebrows middle up 2cm forehead region, lower lip middle 2cm chin area down
Left and right cheek region at domain, nose and pupil intersection.First measure the blank value (R1: place between the eyebrows of 30min after being tested region clean
Middle up 2cm forehead region, R2: lower lip middle 2cm chin area, R3 down: left and right at nose and pupil intersection
Cheek region), then regulation subject adheres to sooner or later daily using above-mentioned trial target, after testing 1 week, 2 weeks, 3 weeks, 4 weeks respectively
Test zone skin elasticity index R1, R2, R3 value (it is 450mbar that negative pressure is constant in test process).
Index explanation: for skin elasticity index R1, R2, R3 closer to 1, the elasticity of skin is better.
R2=Ua/Uf；R5=Ur/Ue；R7=Ur/Uf
Uf --- skin maximum tension amount
Ue --- after constant negative pressure is added on skin, the amount of tension of skin, positioning elastic part amount of tension at 0.1 second.
Ur --- after cancelling negative pressure, skin will restore to the original state rapidly state, equally be divided into elastic portion score value Ur, that is, cancel negative
Pressure is after 0.1 second, the recovery value and visco-elastic portions value or plastic value of skin.
Ua --- from cancellation negative pressure to the recovery value of skin when follow-on test skin surface adds negative pressure again next time.
Four, test result is as follows table 1:
Table 1
From upper table 1: using surrounding using the ganoderma lucidum face cream of embodiment 1-3 and comparative example 1-2, period, R1, R2, R3 gradually rose
Height becomes closer to 1, and the skin elasticity index of subject has very big promotion, it can be seen that, this ganoderma lucidum face cream, which has, to be increased
Skin elasticity, anti-aging, crease-resistant effect, pass through the data comparison of embodiment 1-3 and comparative example 1-2, it can be seen that embodiment
The crease-resistant of the face cream of 1-3, anti-aging, increase skin elasticity effect are more preferable.
Second part:
One, trial target: the ganoderma lucidum face cream of embodiment 1-3 and comparative example 1-2
Two, tested crowd
Gender number: each 50 people of men and women, totally 5 groups
Age: between 30-60 years old, every group of average age 45 ± 2 years old.
Health status: without serious systemic disease, without immune deficiency or autoimmune disease person, no active anaphylaxis
Disease patient, previously to skin-care cosmetics without allergies, whole body does not use hormone medicine and immunosuppressor in nearly January
Person does not participate in other clinical test persons, meets subject and volunteers inclusion criteria.And having senile plaque, spot distribution is similar, spot
Point size color is similar.
Three, test method
Respectively using ganoderma lucidum face cream prepared by example 1-3, comparative example 1-2, using effect is observed and experienced.Application method: by
After examination person cleans face, suitable face cream is pressed lightly on later in face in the palm of the hand, the heating of two hand rubs mutuallies until inhaling completely
Receipts, it is each using once daily morning and evening, adhere to that senile plaque situation and face cream smell, use feeling see the table below using three months
2:
Table 2
As can be seen from the above table, the ganoderma lucidum face cream of embodiment 1-3 is going senile plaque, smell, use feeling, hypo-allergenic aspect all to compare
Ratio 1-2's is good very much.
Specific embodiment described herein is only an example for the spirit of the invention.The neck of technology belonging to the present invention
The technical staff in domain can make various modifications or additions to the described embodiments or replace by a similar method
In generation, however, it does not deviate from the spirit of the invention or beyond the scope of the appended claims.
Claims (10)
1. a kind of ganoderma lucidum face cream, which is characterized in that including following component: Ganodenna Lucidum P.E, moisturizer, emulsifier, ginger fermentation
Extract, blueberry extractive from fermentative, microwax, saualane, water.
2. a kind of ganoderma lucidum face cream according to claim 1, which is characterized in that the ganoderma lucidum face cream is by including following parts by weight
Component be prepared: 1-3 parts of Ganodenna Lucidum P.E, 6-15 parts of moisturizer, 3-7 parts of emulsifier, 1-2 parts of ginger extractive from fermentative,
2-3 parts of blueberry extractive from fermentative, 5-9 parts of microwax, 4-10 parts of saualane, 30-50 parts of water.
3. a kind of ganoderma lucidum face cream according to claim 1 or 2, it is characterised in that: the preparation method of the Ganodenna Lucidum P.E
It is as follows: by weight taking ganoderma lucidum mycelium and Reishi sporule for 1-3:1, to Reishi sporule carry out after broken wall treatment with Ganoderma lucidum mycelium
Body mixing is pulverized to obtain Ultramicro-powder, Ultramicro-powder is carried out decompression boiling refluxing extraction 3-8h, decompression makes water in 40-60
DEG C boiling, aqueous solution and pretreated feedstock are obtained by filtration later, pretreated feedstock is divided into two parts of equivalent, a copy of it carries out
Supercritical CO 2 extraction technology obtains product one, another carry out subcritical abstraction technique obtain product two, by aqueous solution,
Product two is concentrated respectively, is spray-dried and obtains concentration powder one, concentration powder two, and the purification of product one is obtained ganoderma oil, later according to
Weight ratio is that 1:3-5:1-2 takes concentration powder one, ganoderma oil, concentration powder two to be configured to Ganodenna Lucidum P.E.
4. a kind of ganoderma lucidum face cream according to claim 1 or 2, it is characterised in that: the ginger extractive from fermentative, blueberry hair
Being individually placed in two fermentors the preparation method is as follows: ginger and blueberry are cleaned to smash to pieces for ferment extract, sends out toward two respectively
Glucose, white granulated sugar, water, lactic acid bacteria, saccharomycete, acetobacter are added in fermentation tank and carries out anaerobic fermentation, filters respectively later
To ginger fermentation liquid, ginger slag and blueberry fermentation liquid, blueberry residue, sterilized respectively to ginger fermentation liquid and blueberry fermentation liquid,
Concentration, spray drying obtain ginger extractive from fermentative, blueberry extractive from fermentative.
5. a kind of ganoderma lucidum face cream according to claim 4, it is characterised in that: when the raw material cultivation of the Ganodenna Lucidum P.E
Cultivation base includes following component: stalk, ginger slag, blueberry residue, corn stigma, mulberry tree branch, lime, magnesium sulfate, cotton seed hulls, dendrobium nobile
Flower, gypsum, water.
6. a kind of ganoderma lucidum face cream according to claim 5, it is characterised in that: the culture medium is by including following parts by weight
Component is prepared: 30-45 parts of stalk, 5-8 parts of ginger slag, 7-12 parts of blueberry residue, 5-9 parts of corn stigma, mulberry tree branch 25-38 parts,
0.5-1.5 parts of lime, 0.7-1.2 parts of magnesium sulfate, 20-32 parts of cotton seed hulls, 3-5 parts of stone flower, 1-3 parts of gypsum, 70-100 parts of water.
7. a kind of ganoderma lucidum face cream according to claim 5 or 6, it is characterised in that: the culture medium the preparation method is as follows:
(1), stalk, corn stigma, mulberry tree branch, stone flower, 1/3-2/3 ginger slag, 1/4-1/2 blueberry residue and water are stirred first equal
It is even, material heap one is piled, covers fermentation 20-28h with plastic film；
(2), remaining ginger slag, blueberry residue, lime, magnesium sulfate, cotton seed hulls, gypsum is added into material heap one later, stirring is equal
It is even to pile material heap two again, and continue the 12-20h that ferments with plastic film covering；
(3), it is sterilized the material in material heap two to obtain culture medium.
8. a kind of ganoderma lucidum face cream according to claim 7, it is characterised in that: in step (2), need first to ginger slag and indigo plant
Certain kind of berries slag is dry to be lower than 5% to moisture content, is pulverized to obtain Ultramicro-powder later to it.
9. a kind of preparation method of ganoderma lucidum face cream, which comprises the steps of: by moisturizer and ginger extractive from fermentative
It is stirred at 55-80 DEG C to being completely dissolved, microwax is added and Ganodenna Lucidum P.E continues to stir 1-3h, while stirring later
It is cooled to 35-45 DEG C, blueberry extractive from fermentative, emulsifier and water ultrasound 80-150min is added, it is mixed that saualane stirring is added later
It closes and uniformly obtains ganoderma lucidum face cream.
10. a kind of preparation method of ganoderma lucidum face cream according to claim 9, it is characterised in that: the Ganodenna Lucidum P.E exists
Before addition, 10-20min first is ultrasonically treated to it.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111728910A (en) * | 2020-07-03 | 2020-10-02 | 广州无添加主义化妆品有限公司 | Fermented extract of blueberry and snow lotus herb, preparation method and application thereof |
| CN114642614A (en) * | 2022-02-23 | 2022-06-21 | 广州品域美妆创新科技有限公司 | Composition containing ganoderma lucidum and poria cocos and application thereof |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103989619A (en) * | 2014-05-22 | 2014-08-20 | 广东省微生物研究所 | Anti-aging cream of lucid ganoderma and preparation method thereof |
| CN104906028A (en) * | 2015-06-30 | 2015-09-16 | 宋成友 | Yeast composite capable of improving skin and application thereof |
| CN105287336A (en) * | 2015-11-04 | 2016-02-03 | 张家界立功旅游农业发展有限公司 | Blueberry compound mask and preparation method thereof |
| CN105853286A (en) * | 2016-04-29 | 2016-08-17 | 山东复大生物科技有限公司 | Skin care product containing ganoderma lucidum spore oil and preparation method of ganoderma lucidum spore oil |
| CN107440945A (en) * | 2017-08-25 | 2017-12-08 | 晟源康生物科技有限公司 | The nourishing cream and preparation method of glossy ganoderma mycelium fermentation extract |
| CN107648116A (en) * | 2017-10-31 | 2018-02-02 | 广州赛莱拉干细胞科技股份有限公司 | A kind of antiallergy containing Ganoderma spore extract, anti-apolexis composition and preparation method thereof |
| CN108743431A (en) * | 2018-07-27 | 2018-11-06 | 安徽精准医疗产业研究院有限公司 | A kind of small-molecular peptides facial mask of anti-ageing beauty treatment and preparation method thereof |
| CN108888540A (en) * | 2018-09-26 | 2018-11-27 | 南通蛇类治疗研究所 | The wrinkle resistant face cream of ganoderma lucidum |
-
2019
- 2019-08-29 CN CN201910806237.1A patent/CN110522662A/en not_active Withdrawn
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103989619A (en) * | 2014-05-22 | 2014-08-20 | 广东省微生物研究所 | Anti-aging cream of lucid ganoderma and preparation method thereof |
| CN104906028A (en) * | 2015-06-30 | 2015-09-16 | 宋成友 | Yeast composite capable of improving skin and application thereof |
| CN105287336A (en) * | 2015-11-04 | 2016-02-03 | 张家界立功旅游农业发展有限公司 | Blueberry compound mask and preparation method thereof |
| CN105853286A (en) * | 2016-04-29 | 2016-08-17 | 山东复大生物科技有限公司 | Skin care product containing ganoderma lucidum spore oil and preparation method of ganoderma lucidum spore oil |
| CN107440945A (en) * | 2017-08-25 | 2017-12-08 | 晟源康生物科技有限公司 | The nourishing cream and preparation method of glossy ganoderma mycelium fermentation extract |
| CN107648116A (en) * | 2017-10-31 | 2018-02-02 | 广州赛莱拉干细胞科技股份有限公司 | A kind of antiallergy containing Ganoderma spore extract, anti-apolexis composition and preparation method thereof |
| CN108743431A (en) * | 2018-07-27 | 2018-11-06 | 安徽精准医疗产业研究院有限公司 | A kind of small-molecular peptides facial mask of anti-ageing beauty treatment and preparation method thereof |
| CN108888540A (en) * | 2018-09-26 | 2018-11-27 | 南通蛇类治疗研究所 | The wrinkle resistant face cream of ganoderma lucidum |
Non-Patent Citations (3)
| Title |
|---|
| 王建新: "《化妆品植物原料大全》", 30 June 2012 * |
| 陈宗道 等: "《食品学科本科专业英语》", 31 August 2016 * |
| 高文远: "《中药生物工程》", 31 January 2014 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111728910A (en) * | 2020-07-03 | 2020-10-02 | 广州无添加主义化妆品有限公司 | Fermented extract of blueberry and snow lotus herb, preparation method and application thereof |
| CN114642614A (en) * | 2022-02-23 | 2022-06-21 | 广州品域美妆创新科技有限公司 | Composition containing ganoderma lucidum and poria cocos and application thereof |
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Application publication date: 20191203 |