CN113786378B - Toning lotion composition with skin color improving and brightening effects and preparation method thereof - Google Patents
Toning lotion composition with skin color improving and brightening effects and preparation method thereof Download PDFInfo
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- CN113786378B CN113786378B CN202111126548.7A CN202111126548A CN113786378B CN 113786378 B CN113786378 B CN 113786378B CN 202111126548 A CN202111126548 A CN 202111126548A CN 113786378 B CN113786378 B CN 113786378B
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
- A61K8/9717—Rhodophycota or Rhodophyta [red algae], e.g. Porphyra
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/04—Plant cells or tissues
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
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- Cosmetics (AREA)
Abstract
The invention discloses a toning lotion composition with skin color improving and brightening effects and a preparation method thereof. The toning lotion comprises the following components in percentage by weight: 1-35% of skin-brightening efficacy composition, 5-30% of humectant, 0-30% of skin conditioning agent, 0-10% of thickening agent, 0.01-2% of chelating agent, 0.01-1% of solubilizer, a proper amount of pH regulator, a proper amount of preservative, 0.01-1.0% of daily essence and the balance of deionized water. Wherein the component of the efficacy composition is rice fermentation product filtrate, capparis long heart algae extract, apple fruit/littoral celery/rose cell culture extract. The above functional components have effects of keeping moisture, diminishing inflammation, scavenging free radicals, etc., and can reach the skin equilibrium at the muscle base, so that the skin surface becomes fresh and transparent. According to the skin-color-brightening efficacy toning lotion, through scientific combination of raw materials, the safe and effective skin color equalization, whitening and brightening effects are finally achieved by utilizing the synergistic gain among all the efficacy components.
Description
Technical Field
The invention relates to a skin care product and a preparation method thereof, belongs to the technical field of daily chemicals, and particularly relates to a toning lotion composition with skin color improving and brightening effects and a preparation method thereof.
Background
The color of the skin is seen, and the skin is reflected into the retina of the eye again on the skin irradiated by external light, so that a visual effect is generated. If the skin contains abundant water, the epidermal cells are fully stretched, the skin is smooth, more light rays can be reflected to enter eyes, and the skin looks glossy, has high brightness, and is fair and tender. Thus, moisturizing is an important ring for improving skin tone. Second, inflammation is an important way of skin to resist external injury. However, inflammation causes metabolic disorders in the skin, which can stimulate melanin production. Often inflammation subsides, but melanin deposits on the skin surface, forming acne marks, pigmentation, leading to skin dullness.
The fact that the complexion is dull is a comparatively general concept is generally summarized as that the complexion of … … such as pigmentation, yellowing, rough skin, lack of luster, uneven complexion and the like on the face can appear that the whole face has poor complexion and can also have dirty feeling, unclean and aging. The dark complexion seriously affects the mental appearance of individuals.
Therefore, how to develop a safe, effective cosmetic with the effects of improving skin color and brightening skin is a problem to be solved by those skilled in the cosmetic industry.
In the current research, although different plant extract components are applied to cosmetics, the effect of improving the skin color is limited, and meanwhile, the effect of improving the skin color and brightening the skin by combining a plurality of components with the effects of improving the skin color and brightening the skin is not achieved.
Disclosure of Invention
The invention aims to provide a skin-color-improving effect toning lotion composition, which is rich in various active ingredients, and part of effect raw materials are prepared by adopting a cell culture technology, so that the skin permeability is enhanced, the skin is efficiently moisturized, and the skin is deep into fibroblasts of the skin, so that the fibroblasts are stimulated to synthesize collagen and elastin to keep the skin elastic and full, free radicals can be removed, and the skin darkness problem is improved.
Another object of the present invention is to provide a method for preparing the cosmetic water composition with skin color improving and brightening effects.
In order to achieve the above object, the present invention adopts the following technical scheme:
the cosmetic water composition with the effects of improving skin color and brightening comprises the following raw material components in terms of the total weight of the composition:
a skin tone lightening efficacy composition 3.0-30.0%, comprising: 1-20% of rice fermentation product filtrate, 1-20% of kappaphycus alvarezii extract, and 1-20% of apple fruit/coastal thorny celery/rose cell culture extract;
further, the skin color improving efficacy composition comprises the following raw material components:
1-10% of rice fermentation product filtrate, 1-10% of kappaphycus alvarezii extract and 1-10% of apple fruit/coastal thorny celery/rose cell culture extract.
Further, the skin color improving efficacy composition comprises the following raw material components:
1-6% of rice fermentation product filtrate, 1-6% of kappaphycus alvarezii extract and 1-6% of apple fruit/coastal thorny celery/rose cell culture extract.
Furthermore, the toning lotion composition for improving skin color and improving brightening effect comprises the following components in terms of the total weight of the composition:
a skin tone lightening efficacy composition 6.0-18.0%, comprising: 3-8% of rice fermentation product filtrate, 1-5% of kappaphycus alvarezii extract and 2-5% of apple fruit/coastal thorny celery/rose cell culture extract;
in the skin color brightening efficacy composition used in the invention, the apple fruit/coastal thorny celery/rose cell culture extract adopts a cell culture technology, and comprises the following steps:
1) Seed cell collection:
2 parts by weight of fresh brushing sensitive apple fruits, 2 parts by weight of coastal thorny and 3 parts by weight of French rose are preferably taken, the fresh stirring sensitive apple fruits, the coastal thorny and the 3 parts by weight of French rose are washed and disinfected, then the fresh stirring sensitive apple fruits, the 2 parts by weight of French rose are soaked in 5% -20% sodium hypochlorite disinfectant for 20 minutes, sterile water is used for washing to remove disinfectant residues, then the raw materials after cleaning and disinfection are put into a pulverizer, 50mL of MS culture medium is added, the raw materials are pulverized to obtain slurry, 80mg/kg of cellulase is added for 3 hours of treatment, the slurry is filtered by a 100-micron microporous filter and then centrifuged at a low speed, and the supernatant is discarded, and seed cells are collected;
2) Seed cell culture:
inoculating the seed cells collected in the step 1) into a shake flask containing an MS culture medium, and shake culturing at the pH of 5-6 and 25 ℃ for 48 hours at 100r/min, wherein the culture can be stopped when the cell count is more than 20000/mL;
3) Subculture expansion culture:
inoculating the seed cells after the culture in the step 2) into a new MS culture medium, adding 5mg/L of auxin IAA and 50mg/L of pectase, performing suspension culture in a bioreactor, stirring at a speed of 100r/min and a pH of 5-6, introducing sterile oxygen at a speed of 0.03m3/s, performing dark culture for about 20 days, and stopping culture with a cell count of more than 45000/mL;
4) Centrifuging to obtain supernatant, and collecting apple fruit/littoral/Rosa cell culture extract.
Further, the humectant is selected from one or more of glycerin, propylene glycol, 1, 3-propanediol, glycerin acrylate/acrylic acid copolymer, glycerin polyether-26, hexylene glycol, octylene glycol, ethylhexyl glycerin, polyethylene glycol-32, urea, allantoin, PEG/PPG-17/6 copolymer, PPG-28-butanol polyether-35, bis-PEG-18 methyl ether dimethylsilane, sorbitol, and combinations thereof;
the skin conditioner is selected from one or more of Mel extract, arginine, lysine, ornithine, sodium lactate, nicotinamide, yeast extract, hamamelis mollis (HAMAMELIS VIRGINIANA) extract, thermus thermophilus (Thermus) fermentation product, rice chaff extract, ammonium glycyrrhizate, zinc gluconate, caffeine, and biotin;
the thickener is selected from one or a combination of an ammonium acryloyldimethyl taurate/VP copolymer, an ammonium acryloyldimethyl taurate/behenpolyether-25 methacrylate cross-linked polymer, sodium polyacrylate, sodium (ester) acrylic copolymer, polyacrylate-13, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, xanthan gum, carbomer, acrylic acid (ester) C10-30 alkanol acrylate cross-linked polymer;
the chelating agent is selected from one or more of EDTA-disodium, EDTA-tetrasodium and combinations thereof;
the solubilizer is selected from one or more of 1, 2-pentanediol, PEG-60 hydrogenated castor oil, polysorbate-20 and polysorbate-60.
The pH regulator is selected from one or more of citric acid, sodium citrate, tromethamine, hydroxyethyl piperazine ethane sulfonic acid and combinations thereof.
In addition, the invention also discloses a preparation method of the toning lotion composition with the effects of improving skin color and brightening, which comprises the following process steps:
1) Adding water, chelating agent, humectant, thickener, part of antiseptic and pH regulator into water phase pot, stirring and heating to 80-85deg.C, and stirring for 20-25 min;
2) Cooling water, stirring and cooling to 40-45deg.C, adding skin color improving composition, skin conditioner, solubilizer, essence and other antiseptic, adding into emulsifying pot, and stirring for 15-20 min;
3) Continuously stirring and cooling to a temperature lower than 38 ℃, stopping stirring, and discharging after the detection is qualified.
In particular, the cosmetic product of the skin tone improving, lightening efficacy composition of the present invention has a pH in the range of 4 to 10, preferably a pH in the range of 5 to 8, and most preferably a pH in the range of 5 to 7.
In particular, the cosmetic of the composition for improving skin color and improving brightness of the invention can be in a solvent dispersion or suspension mode, can be in the form of emulsified particles or can be in the form of polymer packages.
In particular, the cosmetic of the composition for improving skin color and lightening efficacy of the present invention is a skin care product, in particular an emulsion, an essence, a face cream, an eye cream, a body lotion, a gel, a sun cream.
By means of the technical scheme, the invention has the following advantages and beneficial technical effects:
1) The invention contains a plurality of active ingredients with skin color improving and brightening effects, such as rice fermentation product filtrate, kappaphycus alvarezii extract and apple fruit/littoral celery/rose cell culture extract, and can improve skin color and brighten skin through a plurality of ways.
2) The skin color improving and brightening effect toning lotion composition is selected from rice fermentation product filtrate, kappaphycus alvarezii extract and apple fruit/coastal thorny celery/rose cell culture extract, and through the optimal combination and the effect test, the optimal composition proportion is found, so that the skin color is improved and the skin is brightening.
3) The apple fruit/coastal thorny celery/rose cell culture extract adopts a cell culture technology, so that the plant cell activity is maintained to the maximum extent, and natural lipid inclusion formed on the cell wall is beneficial to transdermal absorption of the functional components. The components of the toning lotion disclosed by the invention are synergistic mutually, so that the effects of safely and effectively improving skin color and brightening skin are achieved.
4) The novel skin-color-improving and brightening toning lotion disclosed by the invention has the advantages that the skin color can be improved, the functional components can permeate into the deep layer of the skin, the skin can be directly and effectively supplemented with nutrition, the generation of natural moisturizing factors is promoted, the skin is efficiently moisturized, the deep antioxidation of the skin is facilitated, and the uneven and dark problems of the skin color are improved.
Drawings
Fig. 1 is a graph showing the values of facial skin color L before and after use of example 1;
fig. 2 shows the values of skin color L for the front and rear arms using example 1;
fig. 3 shows the skin color ITA values for the front and rear arms using example 1;
FIG. 4 is the front and back facial skin gloss using example 1;
FIG. 5 is a clinical evaluation of skin brightness by dermatologists before and after use of example 1;
FIG. 6 is a clinical evaluation of skin whiteness by dermatologists before and after example 1;
fig. 7 is a clinical evaluation of skin gloss by dermatologists before and after example 1.
Detailed Description
The invention discloses a toning lotion composition containing various components with skin color improving and brightening effects and a preparation method thereof. The cosmetic water composition for improving skin color and improving brightness comprises the following raw material components:
1.0-35.0% of skin color brightening efficacy composition, 5-30% of humectant, 0-30% of skin conditioning agent, 0-10% of thickening agent, 0.01-2% of chelating agent, 0.01-1% of solubilizer, proper amount of pH regulator, proper amount of preservative, 0.01-1.0% of daily essence and the balance of deionized water.
The skin color brightening effect composition is prepared by mixing rice fermentation product filtrate, a kappaphycus alvarezii extract and apple fruit/littoral celery/rose cell culture extract.
(1) Rice fermentation product filtrate
Selecting Fall-region rice and preferred saccharomycetes produced in Japan, fermenting to obtain rice fermentation product filtrate, wherein the fermentation liquor is rich in various natural skin nourishing components such as amino acid, polyamine, nucleic acid, fruit acid, sugar and the like, so as to form a natural skin barrier to protect skin, and has the effect of moistening skin.
The rice fermentation product filtrate can promote the generation of hyaluronic acid, promote the proliferation of epidermis and dermis cells, promote the generation of moisture-preserving related factors such as serine palmitoyltransferase, aquaporin, hyaluronic acid synthase 3 and the like, and has high-efficiency moisture preservation and mild use feeling; the sense of experience of high-speed penetration of the skin; so that the skin is more moist and plump and delicate. In addition, the rice fermentation product filtrate can promote the transfer effect of active ingredients and functional ingredients in the cosmetic preparation, and is a basic raw material with excellent performance.
The preparation method comprises the following steps:
1) Pretreatment of fermentation raw materials: selecting Fall-field rice produced in Japan, cleaning rice seeds, adding equal amount of deionized water, crushing into rice pulp, boiling and cooling to 30-40 ℃ for later use;
2) Activating saccharomyces cerevisiae: weighing the selected active Saccharomyces cerevisiae powder according to a mass ratio of 1:10 with rice, adding sterile deionized water with a weight of 10 times of that of the yeast at 38 ℃, fully dissolving, vibrating at a temperature of 38 ℃ at 100r/min, preserving heat for 6 hours, and fully activating;
3) Fermentation: mixing the yeast liquid activated in the step 2) with the rice milk in the step 1), fully stirring, vibrating at the speed of 200-500 r/min, introducing sterile oxygen at the speed of 0.01m < 3 >/s, and continuously fermenting for 48-72 h;
4) Standing the fermentation liquor obtained in the step 3), filtering and collecting a clarified liquor, and obtaining rice fermentation product filtrate.
(2) Capparis longa extract
Capparis longus is a red algae growing in tropical or subtropical regions, such as Hainan, xisha islands, taiwan, etc. in China. The extract contains carrageenan as main component, and contains rich amino acids (such as glycine, leucine, glutamic acid, etc.) and small amount of polyphenols.
The Kappaphycus alvarezii extract can inhibit melanin formation, deeply evolve and whiten skin, has good hygroscopicity, improves the structural integrity of horny layer of dry skin and the biosynthesis function of epidermis, provides sufficient water and nutrient mineral substances for skin, is favorable for skin metabolism, regulates the dynamic balance of skin, improves the phenomenon of water-deficient relaxation of skin, and eliminates dark complexion.
The preparation method comprises the following steps:
1) Pretreatment of raw materials: taking fresh Kappaphycus alvarezii as a raw material, removing impurities such as grass sticks, sediment and the like attached to leaves of the Kappaphycus alvarezii, soaking in 75% ethanol solution for 15-30 min, and airing for standby;
2) Grinding, crushing and enzymolysis: grinding the raw materials in the step 1) in a colloid mill, crushing the ground raw materials by a tissue triturator, adding citric acid, adjusting the pH value of the solution to 4.0-6.0, adding 4X 104-6X 104U/L pectase and 0.5X 104-1X 104U/L cellulase, and carrying out enzymolysis for 3-5 hours at the temperature of 40-60 ℃;
3) Enzyme deactivation: heating the solution obtained after the enzymolysis in the step 2) to boiling, inactivating enzyme for 5-20 minutes, cooling to room temperature, and then extracting for 12 hours at the temperature of 30 ℃ by taking 90% ethanol as an extraction solvent to obtain an extract;
4) Filtering and distilling under reduced pressure: and (3) rapidly filtering the extracting solution in the step (3) by using a Buchner funnel, and distilling the filtrate under reduced pressure to remove ethanol to obtain the Kappaphycus alvarezii extract.
(3) Apple fruit/coastal thorny/rose cell culture extract
The apple fruit cell culture extract contains several procyanidin substances, has effects of scavenging various free radicals, and can be used as antioxidant and antiinflammatory; the seashore parsley is known as a magic marine plant grown on the seashore of b. The more the plant stem cell essence is affected by severe environment, the more the plant stem cell essence has vigorous vitality and has remarkable adaptability to external pressure, the plant stem cell essence extracted from the root of the plant stem cell essence can directly penetrate into the skin fibroblasts, and the capability of the cells to synthesize collagen and elastin is stimulated, so that the plant stem cell essence has the effects of relieving and conditioning skin, mildly removing aged cutin and promoting the natural generation of skin collagen, elastin and other active proteins; the rose extract adopts France white rose as a raw material, and has the effects of scavenging free radicals, whitening and brightening skin and refining skin.
Apple fruit cell culture extract and littoral cress tissue cell culture filtrate can help tighten and tender skin; the Rosa cell culture extract can help skin to deeply resist oxidation and improve darkness and roughness. Plant cell culture is a technology in which callus or other easily dispersible tissues are placed in a liquid culture medium for shake culture under in vitro conditions to obtain free suspension cells, and cells are proliferated by subculture to obtain a large number of cell populations. The natural lipid inclusion extract component is obtained by a plant cell culture technology, so that the skin absorption is promoted, the skin muscle fundus is balanced from inside to outside, and the skin surface becomes fresh and transparent.
The specific preparation method adopts a cell culture technology and comprises the following steps:
1) Seed cell collection: 2 parts by weight of fresh brushing sensitive apple fruits, 2 parts by weight of coastal thorny and 3 parts by weight of French rose are preferably taken, the fresh stirring sensitive apple fruits, the coastal thorny and the 3 parts by weight of French rose are washed and disinfected, then the fresh stirring sensitive apple fruits, the 2 parts by weight of French rose are soaked in 5% -20% sodium hypochlorite disinfectant for 20 minutes, sterile water is used for washing to remove disinfectant residues, then the raw materials after cleaning and disinfection are put into a pulverizer, 50mL of MS culture medium is added, the raw materials are pulverized to obtain slurry, 80mg/kg of cellulase is added for 3 hours of treatment, the slurry is filtered by a 100-micron microporous filter and then centrifuged at a low speed, and the supernatant is discarded, and seed cells are collected;
2) Seed cell culture: inoculating the seed cells collected in the step 1) into a shake flask containing an MS culture medium, and shake culturing at the pH of 5-6 and 25 ℃ for 48 hours at 100r/min, wherein the culture can be stopped when the cell count is more than 20000/mL;
3) Subculture expansion culture: inoculating the seed cells after the culture in the step 2) into a new MS culture medium, adding 5mg/L of auxin IAA and 50mg/L of pectase, performing suspension culture in a bioreactor, stirring at a speed of 100r/min and a pH of 5-6, introducing sterile oxygen at a speed of 0.03m3/s, performing dark culture for about 20 days, and stopping culture with a cell count of more than 45000/mL;
4) Centrifuging to obtain supernatant, and collecting apple fruit/littoral/Rosa cell culture extract.
The cosmetic water composition with the effects of improving skin color and brightening consists of the rice fermentation product filtrate, the kappaphycus alvarezii extract and the apple fruit/coastal thorn celery/rose cell culture extract, and the skin dryness is relieved and the dermis quality is improved through the moisturizing and moisturizing effects of the composition base.
The above functional components have effects of keeping moisture, diminishing inflammation, scavenging free radicals, etc., and can reach the skin equilibrium at the muscle base, so that the skin surface becomes fresh and transparent.
Meanwhile, the extract of the cell culture of the apple fruit/the coastal thorny celery/the rose is prepared by adopting a cell culture technology, and the cell wall is a natural lipid inclusion, so that the functional components are easier to be absorbed through skin and play a role.
The toning lotion composition with the effects of improving skin color and brightening disclosed by the invention has the advantages that through scientific combination of raw materials, the safe and effective skin color balancing, whitening and brightening effects are finally achieved by utilizing the synergistic gain among the functional components, so that the skin is moist and full, and healthy luster is emitted from inside to outside.
The components of the composition have synergistic effect, so that various active substances can be promoted to permeate the skin, uneven skin color can be effectively improved, the nutrition supply of the skin can be promoted, the antioxidation of the skin can be further facilitated, the darkness can be reduced, the skin color can be finally improved, and the skin can be healthily and transparent from inside to outside.
The invention is illustrated by the following examples which are given for further illustration of the invention and are not intended to limit the scope of the invention. Some insubstantial modifications and adaptations of the invention by others are within the scope of the invention.
The following percentages (%) are mass percentages unless otherwise indicated. All raw material components used in the invention are commercial products.
Examples 1 to 4
A cosmetic water composition with skin color improving and brightening effects comprises the raw materials of examples 1-4 in proportion as shown in the following table 1.
TABLE 1 raw material composition ratios (unit: mass%) of examples 1-4
The preparation process method of the toning lotion composition with the skin color improving and brightening effects in the embodiments 1-4 can be expressed as follows:
1) Adding water, allantoin, sorbitol, EDTA-disodium, citric acid, sodium citrate, ethylhexyl glycerol, glycerol acrylate/acrylic acid copolymer, polyethylene glycol-32, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer and methylparaben into a water phase pot, stirring and heating to 80-85 ℃, and keeping the temperature and stirring for 20-25 minutes;
2) Adding cooling water, stirring and cooling to 40-45deg.C, adding skin color improving composition, sodium lactate, rice chaff extract, 1, 2-pentanediol, essence, and phenoxyethanol into emulsifying pot, stirring for 15-20 min;
3) Continuously stirring and cooling to a temperature lower than 38 ℃, stopping stirring, and discharging after the detection is qualified.
The pH of examples 1-4 was 5.5-6.5, respectively.
Effect verification test example
Facial skin color Effect test 1
1. The tester: 30 healthy people (20-35 years old), women; the formulation of example 1 was tested and the control was a blank.
2. Test part: the color ITA degree of the facial skin is less than 50, and the facial skin has no obvious redness, skin injury, scar and the like.
3. Test instrument: visia-CR.
4. The test indexes are as follows: the higher the value of the skin color L, the brighter the skin.
5. The test results are shown in fig. 1 and table 2 below:
table 2 skin color L after face use example 1
| Skin colour L | Before use | After 7 days of use | After 14 days of use | After 28 days of use |
| Sample of | 70.69 | 70.95 | 71.16 | 71.15 |
| Control | 70.75 | 70.88 | 71.08 | 71.00 |
As seen from the results of fig. 1 and table 2, compared to before the sample was used: after 7 days of sample application, the skin color L of the sample area increased no significantly by 0.36% and the skin color L of the control area increased no significantly by 0.19%; after 14 days of using the sample, the skin color L of the sample area increased significantly by 0.66% and the skin color L of the control area increased non-significantly by 0.47%; after 28 days of use of the sample, the skin color L of the sample area increased significantly by 0.65% and the skin color L of the control area increased non-significantly by 0.36%.
The significant increase in skin color L after use of example 1 demonstrates that the skin tone improving and lightening lotion of the present invention has a relatively significant lightening effect.
Arm skin color effect test 2
1. The tester: 30 healthy people (20-35 years old), women; the formulation of example 1 was tested and the control was a blank.
2. Test part: the skin on the inner sides of the arms and the forearms of the hands is dark, and the conditions of obvious redness, skin injury, scars and the like are avoided.
3. Test instrument: CL400.
4. The test indexes are as follows: the higher the skin color L, the brighter the skin; the higher the value of ITA, the more white the skin color is indicated.
5. The test results are shown in FIGS. 2-3 and tables 3-4.
Table 3 skin color L after arm application example 1
| Skin colour L | Before use | After 7 days of use | After 14 days of use | After 28 days of use |
| Sample of | 65.75 | 66.07 | 66.25 | 66.55 |
| Control | 65.92 | 65.87 | 65.94 | 65.99 |
TABLE 4 skin color ITA° after arm application example 1
| Skin color ITA DEG | Before use | After 7 days of use | After 14 days of use | After 28 days of use |
| Sample of | 51.11 | 51.47 | 51.56 | 51.76 |
| Control | 51.03 | 50.90 | 50.85 | 50.87 |
As shown in fig. 2-3 and tables 3-4, after 7 days of sample application, the skin color L of the sample area did not significantly increase by 0.48% and the skin color L of the control area did not significantly decrease by 0.08%; the skin color ITA degree value of the sample area is obviously increased by 0.69%, and the skin color ITA degree value of the control area is not obviously reduced by 0.25%; after 14 days of using the sample, the skin color L of the sample area increased significantly by 0.75% and the skin color L of the control area increased non-significantly by 0.02%; the skin color ITA degree value of the sample area is obviously increased by 0.88%, and the skin color ITA degree value of the control area is not obviously reduced by 0.35%; after 28 days of use of the sample, the skin color L of the sample area increased significantly by 1.22% and the skin color L of the control area increased significantly by 0.64%; the skin color ita° value of the sample area was significantly increased by 1.26%, and the skin color ita° of the control area was not significantly decreased by 0.32%.
The above data shows that the skin color L and ITA values increase significantly after using example 1, demonstrating that the skin tone improving, lightening effect lotion of the present invention has a relatively significant lightening and whitening skin tone effect.
Skin gloss effect test 3
1. The tester: 30 healthy people (20-35 years old), women; the formulation of example 1 was tested and the control was a blank.
2. Test part: the color ITA degree of the facial skin is less than 50, and the facial skin has no obvious redness, skin injury, scar and the like.
3. Test instrument: GL200.
4. The test indexes are as follows: the higher the measurement, the better the skin gloss.
5. The test results are shown in fig. 4 and table 5 below:
TABLE 5 skin gloss after use of example 1
| Skin gloss | Before use | After 7 days of use | After 14 days of use | After 28 days of use |
| Sample of | 7.91 | 8.33 | 8.22 | 8.33 |
| Control | 7.71 | 7.73 | 7.62 | 7.67 |
The results in fig. 4 and table 5 show that, compared to before the sample was used: after 7 days of using the sample, the skin glossiness value of the sample area is remarkably increased by 5.34%, and the skin glossiness value of the control area is not remarkably increased by 0.20%; after 14 days of using the sample, the skin glossiness value of the sample area is obviously increased by 3.96%, and the skin glossiness value of the control area is not obviously reduced by 1.25%; after 28 days of use of the sample, the skin gloss value of the sample area increased significantly by 5.37% and the skin gloss value of the control area decreased no significantly by 0.57%. Compared to the control area: after 7 days of using the sample, the skin glossiness variation values of the sample areas are significantly different; after 14 days of using the sample, the skin glossiness variation values of the sample areas are significantly different; the skin gloss change values were significantly different in the sample area after 28 days of sample use.
The results show that the toning lotion provided by the invention can obviously increase the glossiness of skin and has the effects of improving the complexion and brightening.
Dermatological doctor clinical evaluation 4
1. Evaluation object: 30 healthy people (20-35 years old), women; the formulation of example 1 was tested and the control was a blank.
2. Evaluation site: the color ITA degree of the facial skin is less than 50, and the facial skin has no obvious redness, skin injury, scar and the like.
3. Evaluation index: skin brightness, skin whiteness, skin luster.
4. Scoring criteria: skin brightness: a score of 0 indicates skin is opaque and light is not reflected, and a score of 9 indicates skin is transparent and light is reflected; whitening of skin: score 0 indicates fair, dark skin tone, score 9 indicates very fair, porcelain-like skin tone; skin gloss: a score of 0 indicates that the skin tone lacks gloss, gives off unhealthy gloss, and a score of 9 indicates that the skin tone is shiny, giving off healthy gloss.
5. Evaluation results: as shown in fig. 5-7 and tables 6-8.
TABLE 6 dermatological doctor clinical assessment of (facial) skin brightness
| Skin brightness | Before use | After 14 days of use | After 28 days of use |
| Sample of | 5.13 | 5.26 | 5.87 |
| Control | 5.10 | 5.19 | 5.45 |
TABLE 7 dermatological doctor clinical assessment of the whiteness of (facial) skin
| Skin whitening degree | Before use | After 14 days of use | After 28 days of use |
| Sample of | 4.97 | 5.26 | 5.81 |
| Control | 4.94 | 5.03 | 5.35 |
TABLE 8 skin practitioner clinical assessment of (facial) skin glossiness
| Skin gloss | Before use | After 14 days of use | After 28 days of use |
| Sample of | 5.19 | 5.55 | 5.90 |
| Control | 5.19 | 5.23 | 5.42 |
Compared to before the sample was used: after 14 days of using the sample, the average value of the clinical scores of the skin in the sample area is not increased by 2.52 percent, and the average value of the clinical scores of the skin in the control area is not increased by 1.90 percent; the average value of the fair clinical scores of the skin of the sample area is not remarkably increased by 5.84 percent, and the average value of the fair clinical scores of the skin of the control area is not remarkably increased by 1.96 percent; the average value of the clinical scores of the glossiness of the skin of the sample area is obviously increased by 6.83%, and the average value of the clinical scores of the glossiness of the skin of the control area is not obviously increased by 0.62%; after 28 days of using the sample, the average value of the clinical scores of the skin in the sample area is remarkably increased by 14.47%, and the average value of the clinical scores of the skin in the control area is remarkably increased by 6.96%; the mean value of the fair clinical scores of the skin of the sample area is increased by 16.88%, and the mean value of the fair clinical scores of the skin of the control area is increased by 8.50%; the average value of the clinical scores of the glossiness of the skin of the sample area is obviously increased by 13.66%, and the average value of the clinical scores of the glossiness of the skin of the control area is not obviously increased by 4.35%.
Compared to the control area: the clinical score change value of the brightness of the skin of the sample area is obviously different after the sample is used for 28 days; the change value of the whitening degree clinical score of the skin of the sample area is obviously different; the change in the clinical score of the skin in the sample area was significantly different. The skin-whitening toning lotion has good skin-whitening and whitening effects, and can make skin bright and healthy.
Safety test 5
1. Number of test persons: 30 healthy people, 13 men and 17 women; the age range is 20-45 years.
2. The testing method comprises the following steps: a suitable plaque tester having an area of not more than 50mm2 and a depth of about 1mm was selected, and about 0.020 to 0.025mL (g) of the test sample example 1 was added to the plaque tester by a closed plaque test method. The patch tester was applied to the forearm of the subject, the test substance was removed after 24 hours, and skin reactions were observed at 0.5, 24, and 48 hours after the removal, and the results were recorded according to the skin reaction classification standard in cosmetic safety technical Specification 2015.
3. The evaluation criteria are shown in Table 9 below:
TABLE 9 skin adverse reaction grading criteria
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The results show that: the results of the human skin patch test show that the scoring grades of 0.5h, 24h and 48h at 3 observation time points after the patch is removed are all 0 score, namely, 0 cases of 30 subjects have positive reactions, and according to the specification in the cosmetic safety technical Specification (2015 edition), the test object does not cause skin adverse reactions to the subjects in the batch.
Synergistic test example 6 (comparative examples 1 to 6)
Toning lotion with skin color improving and brightening effects, and the proportion and content of the raw material components in comparative examples 1-6 are shown in the following table 10.
Table 10 comparative examples 1 to 6 raw material composition ratio (unit: mass%)
The preparation process method of the toning lotion with moisturizing and soothing effects of comparative examples 1-6 can be expressed as follows:
1) Adding water, allantoin, sorbitol, EDTA-disodium, citric acid, sodium citrate, ethylhexyl glycerol, glycerol acrylate/acrylic acid copolymer, polyethylene glycol-32, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer and methylparaben into a water phase pot, stirring and heating to 80-85 ℃, and keeping the temperature and stirring for 20-25 minutes;
2) Adding cooling water, stirring and cooling to 40-45deg.C, adding skin color improving composition, sodium lactate, rice chaff extract, 1, 2-pentanediol, essence, and phenoxyethanol into emulsifying pot, stirring for 15-20 min;
3) Continuously stirring and cooling to a temperature lower than 38 ℃, stopping stirring, and discharging after the detection is qualified.
Skin color (L, ITA) and gloss tests were performed two weeks after face use example 1 and comparative examples 1-6, and the test results are shown in table 11.
Table 11 examples 1 and comparative examples 1 to 6 skin color (L, ITA) and gloss change values before and after use
From the data in the table it can be seen that the skin color L-increase values are ordered by size: example 1> comparative example 2>3>5>1>4>6; the skin color ITA degree value increment values are ordered according to the size: example 1> comparative example 2>3>5>4>1>6; the skin gloss increase values are ordered by size: example 1> comparative example 2>3>5>4>1>6.
In conclusion, the skin color improving and brightening effect compound has the obvious skin color improving and brightening effects through the synergistic effect among the components, and is more obvious than the skin color improving effects of the combination of one component and two components.
The present invention is not limited to the preferred embodiments, but can be modified, equivalent, and modified in any way without departing from the technical scope of the present invention.
Claims (3)
1. A toning lotion composition with skin color improving and brightening effects, which is characterized in that:
the composition comprises the following raw material components in percentage by weight:
allantoin 1.5-2%
Sorbitol 1-1.5%
EDTA-disodium 0.05-0.06%
Citric acid 0.03%
Sodium citrate 0.24%
Ethylhexyl glycerol 3-6%
Glycerol 2%
Glycerol acrylate/acrylic acid copolymer 0.3-0.9%
1, 2-pentanediol 0.8-1%
Polyethylene glycol-32 1-2.5%
A skin tone lightening efficacy composition comprising: 4-6% of rice fermentation product filtrate, 2-3% of kappaphycus alvarezii extract, and 3-3.5% of apple fruit/littoral celery/rose cell culture extract;
sodium lactate 1-1.5%
3.8-4.3% of rice chaff extract
Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer 0.5%
Essence 0.02%
0.15% of methylparaben
Phenoxyethanol 0.35%
The balance of water.
2. The cosmetic water composition having skin tone improving and lightening efficacy according to claim 1, wherein: the composition comprises the following raw material components in percentage by weight:
allantoin 2%
Sorbitol 1.2%
EDTA-disodium 0.05%
Citric acid 0.03%
Sodium citrate 0.24%
Ethylhexyl glycerol 5%
Glycerol 2%
Glycerol acrylate/acrylic acid copolymer 0.3%
1.0% of 1, 2-pentanediol
Polyethylene glycol-32.5%
Rice fermentation product filtrate 6.0%
3.0% of Kappaphycus alvarezii extract
Apple fruit/coastal thorny celery/rose cell culture extract 3.0%
Sodium lactate 1.5%
3.8% of rice chaff extract
Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer 0.5%
Essence 0.02%
0.15% of methylparaben
Phenoxyethanol 0.35%
The balance of water.
3. The method for producing a cosmetic water composition having an effective component for improving skin tone and improving brightness according to claim 1 or 2, characterized in that,
the method comprises the following steps of:
1) Adding water, allantoin, sorbitol, EDTA-disodium, citric acid, sodium citrate, ethylhexyl glycerol, glycerol acrylate/acrylic acid copolymer, polyethylene glycol-32, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer and methylparaben into a water phase pot, stirring and heating to 80-85 ℃, and keeping the temperature and stirring for 20-25 minutes;
2) Adding cooling water, stirring and cooling to 40-45deg.C, adding skin color improving composition, sodium lactate, rice chaff extract, 1, 2-pentanediol, essence, and phenoxyethanol into emulsifying pot, stirring for 15-20 min;
3) Continuously stirring and cooling to a temperature lower than 38 ℃, stopping stirring, and discharging after the detection is qualified.
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