CN110314118A - Have effects that anti-aging, the composition repaired and its preparation method and application - Google Patents
Have effects that anti-aging, the composition repaired and its preparation method and application Download PDFInfo
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- CN110314118A CN110314118A CN201910618816.3A CN201910618816A CN110314118A CN 110314118 A CN110314118 A CN 110314118A CN 201910618816 A CN201910618816 A CN 201910618816A CN 110314118 A CN110314118 A CN 110314118A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
Have effects that anti-aging, the composition repaired and its preparation method and application the invention discloses a kind of.By weight percentage, the composition includes: Apple cell encapsulation object 0.1~10.0%, rose extract 0.01~1.0%, eryngium maritimum callus tissue culture filtrate 0.01~5.0%, hexapeptide -11 0.003~0.006%, palmityl tripeptides -1 0.01~0.5%, palmityl tetrapeptide -7 0.01~0.5%, dipeptides diaminobutyryl benzyl amide diacetin 0.01~0.5%, emulsifier 0.1~1%.The Apple cell encapsulation object is made of Apple cell activity object and infiltration Apple cell activity object Nei Wen Quince leaf polyphenol extract and Flos Rosae Rugosae extract, the outer surface of Apple cell activity object is coated with phospholipid bilayer, the composition has effects that anti-aging, repairs, and has the characteristics that function-stable is lasting.
Description
Technical field
The present invention relates to a kind of anti-aging skin care product compositions, belong to cosmetic technical field, more particularly to a kind of tool
There are anti-aging, the composition for repairing effect and its preparation method and application.
Background technique
Nowadays, people are higher and higher to the pursuit of beauty, and skin aging problem is just greatly paid close attention to.Skin aging is one
A irreversible process, there is presently no the processes that method can reverse aging, but can alleviate this to a certain extent
Process.In general, women 25 years old or so when being in the best state in skin all one's life, but hereafter will gradually become
Difference, 30 years old front and back just will appear the visible signs of aging of naked eyes.Therefore, people have great need to the anti-senescence function of cosmetics
It asks.
Since cosmetics are on the skin for be applied directly to user.Therefore, can measure makeup to the toxicity of cosmetics
The major criterion of moral character energy.With the development of science and technology, vegetalization cosmetic is more and more, also increasingly pursued by people.Currently,
When preparing vegetalization cosmetic, mainly the skin-protecting function of cosmetics and skin care performance are investigated.Therefore, technical staff also leads
If the parameter of raw material selection and preparation process to skin care item is adjusted, to obtain the good skin-protection product of performance.
However, raw material selection in the prior art and preparation technology parameter adjustment can not be controlled steadily and be determined between raw material
Amount and qualitative relationship so that affecting the quality stability of vegetalization cosmetic are unfavorable for that the function of cosmetics is preferably presented
Effect and one of ordinary skill in the art's technical problem urgently to be solved.
Summary of the invention
For the prior art there are above-mentioned technical problem, the object of the present invention is to provide one kind to have anti-aging, repairs function
The composition of effect has the characteristics that function-stable is lasting.
It is a further object of the present invention to provide it is a kind of it is above-mentioned have effects that anti-aging, reparation composition preparation method and
The composition is preparing the application in cosmetics.
To achieve the above object, the present invention provides technical solution below:
The invention discloses a kind of compositions for having effects that anti-aging, repairing, including following components in percentage by weight:
Apple cell encapsulation object 0.1-10.0%；
Rose (ROSA SPP.) extract 0.01~1.0%；
Hexapeptide -11 0.003~0.006%；
Palmityl tripeptides -1 0.01~0.5%；
Palmityl tetrapeptide -7 0.01~0.5%；
Eryngium maritimum (ERYNGIUM MARITIMUM) callus tissue culture filtrate 0.01~5.0%；
Emulsifier 0.1~1%；
Dipeptides diaminobutyryl benzyl amide diacetin 0.01~1%.
Wherein, the Apple cell encapsulation object by Apple cell activity object and penetrates into the Apple cell
Wen Quince leaf polyphenol extract and Flos Rosae Rugosae extract composition in active matter, the appearance bread of the Apple cell activity object
It is covered with phospholipid bilayer；
Weight percent of the phospholipid bilayer in the Apple cell encapsulation object is 0.001~0.002%；
Weight percent of the Suo Shu Wen Quince leaf polyphenol extract in the Apple cell encapsulation object is 0.1~5%；
Weight percent of the Flos Rosae Rugosae extract in the Apple cell encapsulation object is 0.1~5%.
Wherein, eryngium maritimum (ERYNGIUM MARITIMUM) the callus tissue culture filtrate is careless oil, Common Borage
One of oil and castor oil or any two or more mixture.
Wherein, the emulsifier is polyglyceryl fatty acid ester, alkyl poly glucoside, polyol partial esters and amino acid and peptide
One of class emulsifier or any two or more mixture.
Wherein, the Apple cell activity object is the apple cells freeze-dried powder of NAOLYS company, France production；
Rose (ROSA SPP.) extract is rose (ROSA SPP.) extract of NOLYS company, France production；
The hexapeptide -11 is the hexapeptide -11 of U.S. Active Concepts company production；
The palmityl tripeptides -1 are the palmityl tripeptides -1 of France Sederma production；
The palmityl tetrapeptide -7 is the palmityl tetrapeptide -7 of France Sederma production；
The dipeptides diaminobutyryl benzyl amide diacetin is the dipeptides diamino fourth of dutch royal DSM N. V. production
Acyl benzyl amide diacetin dipeptides diaminobutyryl benzyl amide diacetin；
Suo Shu Wen Quince polyphenol leaf extract is BERKEM company, France Sheng Chan Wen Quince polyphenol leaf extract；
The Flos Rosae Rugosae extract is the Flos Rosae Rugosae extract of BERKEM company, France production；
The eryngium maritimum callus tissue culture filtrate is the eryngium maritimum of Biotech Marine company, France production
(ERYNGIUM MARITIMUM) callus tissue culture filtrate.
The effect of being more convenient for realizing the combination in this way.
In addition, the present invention also provides the above-mentioned preparation method with anti-aging, the composition repaired, including it is following
Step:
Step 1: preparing Apple cell encapsulation object
The two is put into mixed dissolution in clear water by a) difference Cheng Qu Wen Quince leaf polyphenol extract and Flos Rosae Rugosae extract,
The weight ratio for obtaining extract solution , Suo Shu Wen Quince leaf polyphenol extract, the Flos Rosae Rugosae extract and the clear water is 1:
1:20~30；
B) the Apple cell activity object for weighing the dewatering state of formula ratio respectively throws the apple cells active matter
Enter into above-mentioned extraction solution and impregnate 2~3h, so that imbitition occurs for the Apple cell activity object, obtains imbibition
The weight ratio of apple cells active matter, the Apple cell activity object and the extract solution is 1:10~15；
C) water extra in imbibition apple cells active matter is filtered out, using phosphatidyl choline and imbibition apple cells active matter
0.5~1h is mixed under room temperature, it is double that one layer of phosphatide then is made in imbibition apple cells activity exterior surface by film dispersion method
Layer liposome is Apple cell encapsulation object；
Step 2: the composition that preparation has effects that anti-aging, repairs
A) Apple cell encapsulation object, rose (ROSA SPP.) extract, hexapeptide -11, dipeptides two of formula ratio are weighed
Aminobutyryl benzyl amide diacetin, the palmityl tripeptides -1, palmityl tetrapeptide -7, eryngium maritimum (ERYNGIUM
MARITIMUM) callus tissue culture filtrate and emulsifier；
B) first by the rose (ROSA SPP.) extract, hexapeptide -11, the palmityl tripeptides -1, palmityl tetrapeptide -
7, dipeptides diaminobutyryl benzyl amide diacetin, the filter of eryngium maritimum (ERYNGIUM MARITIMUM) callus tissue culture
Liquid and emulsifier, which are put into, mixes slowly 2~3h under room temperature in batch mixer, then that the Apple cell encapsulation object is slow
It is added in the batch mixer, continues to mix slowly 0.5~1h, the composition for having effects that anti-aging, repairing is made.
In addition, have effects that anti-aging, the composition repaired are preparing the application in cosmetics the present invention also provides above-mentioned,
It is described to have effects that anti-aging, the composition repaired account for the 0.3~20% of cosmetic formulations total amount.
Furthermore, the cosmetics further include customary adjuvant, and the customary adjuvant contains: deionized water, moisturizer,
One of conditioner, thickener, preservative, essence are a variety of.
Furthermore, creme, emulsion, essence lotion or facial mask form is made in the cosmetics.
By above-mentioned technical proposal, the invention has the following beneficial effects:
1) the Apple cell encapsulation object in the present composition is as described in Apple cell activity object and infiltration
Apple cell activity object Nei Wen Quince leaf polyphenol extract and Flos Rosae Rugosae extract composition, such Shi get Wen Quince leaf polyphenol mention
Take object and Flos Rosae Rugosae extract that can qualitative, quantitatively be enriched in Apple cell activity object, Ti high Wen Quince leaf polyphenol
Stability is cooperateed between extract, Flos Rosae Rugosae extract and Apple cell activity object, to improve cosmetics function
Stability, show better function conducive to composition.
2) Apple cell activity object of the invention can inhibit the release of the derivative relaxing factor NO of vascular endothelial cell, have
The problem of alleviating cutis laxa of effect makes skin be suitable for the influence of environment and stands out against extraneous infringement；Apples
Real cell encapsulation object surface forms a phospholipid bilayer, so that the affinity of Apple cell encapsulation object and human skin is more
It is good, so that composition is easier to be absorbed by the skin.
3) the Wen Quince polyphenol extract of Ben Faming, for the polyphenols for the flavone compound that is saccharified, water-soluble, energy
It penetrates into , Qie Wen Quince polyphenol extract in Apple cell activity object and is able to suppress tumor necrosis factor TNF-alpha and inhibition
Inflammatory factor interleukin-8 inhibits tumor necrosis factor TNF-alpha, reduces the third of the generation of skin sensitivity caused by environmental pollution
Dialdehyde, improves the tolerance of skin, thus inflammatory factor interleukin-8 is inhibited to releive impaired skin, improves the reparation function of skin
Energy.
4) Flos Rosae Rugosae extract of the invention stimulation skin cell keeps good respiration, so that cell breathes
A stable and effective frequency is maintained, so that excreting the toxin of skin in metabolic processes；Rose
Extract can effectively slow down cellular oxidation problem caused by air pollution, to reduce the generation of free radical, and then reduce
Sebum peroxidating improves the repair function of skin；And Flos Rosae Rugosae extract and the tyrosinase effect for generating melanin, adjusting subtract
Few melanin production, and then reduce the generation of pigmentation and spot.
5) rose of the invention (ROSA SPP.) extract can prevent skin caused by air pollution from damaging, and push skin
It breathes, fight the obscure colour of skin, there is anti-oxidant, anti-aging function；Hexapeptide -11, dipeptides diaminobutyryl benzyl amide diethyl
Hydrochlorate dipeptides diaminobutyryl benzyl amide diacetin activity with higher can promote the work of hEGF's synthesis
With achieving the effect that efficiently to repair, moisturizing and remove scar, further improve reparation effect of composition.
6) present invention passes through the concentration of Kong Tiao Jie Wen Quince leaf polyphenol extract and the concentration of Flos Rosae Rugosae extract, Apples
Real cell activity object Xi Shou Wen Quince leaf polyphenol extract and Flos Rosae Rugosae extract by way of imbibition, and pass through film dispersion method
So that the surface of Apple cell encapsulation object has coated phospholipid bilayer, there is simple process, be suitable for large-scale production and application.
Detailed description of the invention
Fig. 1 is the effect contrast figure that releives of anti-aging remediation composition obtained by embodiment 1；
Fig. 2 is the anti-wrinkle effect comparison diagram of anti-aging remediation composition obtained by embodiment 1；
Fig. 3 is the release slip test of the relaxation factor NO of anti-aging remediation composition obtained by embodiment 1；
Fig. 4 is the TNF-α ratio decline figure of anti-aging remediation composition obtained by embodiment 1；
Fig. 5 is the interleukin-8 ratio decline figure of anti-aging remediation composition obtained by embodiment 1；
Fig. 6 is the malonaldehyde ratio decline figure of anti-aging remediation composition obtained by embodiment 1.
Specific embodiment
The present invention is described in further details below in conjunction with by specific preferred embodiment combination attached drawing, but the present invention is simultaneously
It is not limited only to embodiment below.
Have effects that anti-aging, the composition repaired and its preparation method and application the invention discloses a kind of.By weight
Percentages, the composition include: Apple cell encapsulation object 0.1~10.0%, rose extract 0.01~1.0%, shore
The perverse celery callus tissue culture filtrate 0.01~5.0% in sea, hexapeptide -11 0.003%~0.006%, palmityl tripeptides -10.01
~0.5%, palmityl tetrapeptide -7 0.01~0.5%, emulsifier 0.1~1%, dipeptides diaminobutyryl benzyl amide oxalic acid
Salt 0.01~1%.
The Apple cell encapsulation object is by Apple cell activity object and penetrates into Apple cell activity object
Wen Quince leaf polyphenol extract and Flos Rosae Rugosae extract composition, the outer surface of Apple cell activity object are coated with phospholipid bilayer,
The composition has effects that anti-aging, repairs, and has the characteristics that function-stable is lasting.
In the examples below, the Apple cell activity object is that the apple cells of NAOLYS company, France production freeze
Dry powder.
Rose (ROSA SPP.) extract is rose (ROSA SPP.) extract of NOLYS company, France production；
The hexapeptide -11 is the hexapeptide -11 of U.S. Active Concepts company production；
The palmityl tripeptides -1 are the palmityl tripeptides -1 of France Sederma production；
The palmityl tetrapeptide -7 is the palmityl tetrapeptide -7 of France Sederma production；
The dipeptides diaminobutyryl benzyl amide diacetin is the dipeptides diamino fourth of dutch royal DSM N. V. production
Acyl benzyl amide diacetin；
Suo Shu Wen Quince polyphenol leaf extract is BERKEM company, France Sheng Chan Wen Quince polyphenol leaf extract；
The Flos Rosae Rugosae extract is the Flos Rosae Rugosae extract of BERKEM company, France production, is more convenient for realizing the group in this way
The effect of conjunction.
Embodiment 1 (preparation of anti-aging remediation composition)
A kind of composition for having effects that anti-aging, repairing, including following components in percentage by weight:
Apple cell encapsulation object 10.006%；Rose (ROSA SPP.) extract 0.01%, hexapeptide -11
0.006%；Palmityl tripeptides -1 0.5%；Palmityl tetrapeptide -7 0.5%, eryngium maritimum (ERYNGIUM MARITIMUM) are more
Injured tissue culture filtrate 1.0%；Emulsifier is alkyl poly glucoside agent 0.5%.
In the present embodiment, the Apple cell encapsulation object is by Apple cell activity object and penetrates into the Apples
Real cell activity object Nei Wen Quince leaf polyphenol extract and Flos Rosae Rugosae extract form, outside the Apple cell activity object
Surface is coated with phospholipid bilayer；
Weight percent of the phospholipid bilayer in the Apple cell encapsulation object is 0.002%；
Weight percent of the Suo Shu Wen Quince leaf polyphenol extract in the Apple cell encapsulation object is 5%；
Weight percent of the Flos Rosae Rugosae extract in the Apple cell encapsulation object is 5%.
In the present embodiment, eryngium maritimum (ERYNGIUM MARITIMUM) the callus tissue culture filtrate be careless oil,
Both borage oils are the mixture of 1:1 in mass ratio.
This has effects that the preparation method of anti-aging, the composition repaired, comprising the following steps:
Step 1: preparing Apple cell encapsulation object
The two is put into mixed dissolution in clear water by a) difference Cheng Qu Wen Quince leaf polyphenol extract and Flos Rosae Rugosae extract,
The weight ratio for obtaining extract solution , Suo Shu Wen Quince leaf polyphenol extract, the Flos Rosae Rugosae extract and the clear water is 1:
1:30；
B) the Apple cell activity object for weighing the dewatering state of formula ratio respectively throws the apple cells active matter
Enter into above-mentioned extraction solution and impregnate 2~3h, so that imbitition occurs for the Apple cell activity object, obtains imbibition
The weight ratio of apple cells active matter, the Apple cell activity object and the extract solution is 1:15；
C) water extra in imbibition apple cells active matter is filtered out, using phosphatidyl choline and imbibition apple cells active matter
1h is mixed under room temperature, and one layer of phospholipid bilayer lipid is then made in imbibition apple cells activity exterior surface by film dispersion method
Body；
Step 2: preparation anti-aging remediation composition
A) Apple cell encapsulation object, the rose (ROSA SPP.) extract of formula ratio, hexapeptide -11, palm fibre are weighed
Palmitic acid acyl tripeptides -1, palmityl tetrapeptide -7, dipeptides diaminobutyryl benzyl amide diacetin, eryngium maritimum (ERYNGIUM
MARITIMUM) callus tissue culture filtrate and emulsifier；
B) first by the rose (ROSA SPP.) extract, hexapeptide -11, palmityl tripeptides -1, palmityl tetrapeptide -
7, dipeptides diaminobutyryl benzyl amide diacetin dipeptides diaminobutyryl benzyl amide diacetin, eryngium maritimum
(ERYNGIUM MARITIMUM) callus tissue culture filtrate and emulsifier, which are put into batch mixer, mixes slowly 3h under room temperature,
Then the Apple cell encapsulation object is slowly added into the batch mixer, continues to mix slowly 1h, obtained anti-aging,
Remediation composition.
Embodiment 2 (preparation of anti-aging remediation composition)
It is a kind of to have effects that reparation, crease-resistant composition, including following components in percentage by weight:
Apple cell encapsulation object 5.0%；Rose (ROSA SPP.) extract 1%；Hexapeptide -11 0.003%；Palm
Acyl tripeptides -1 0.01%；Palmityl tetrapeptide -7 0.01%, eryngium maritimum (ERYNGIUM MARITIMUM) callus tissue culture
Object filtrate 3.0%；Polysorbate -20 is emulsifier 1%.
In the present embodiment, the Apple cell encapsulation object is by Apple cell activity object and penetrates into the Apples
Real cell activity object Nei Wen Quince leaf polyphenol extract and Flos Rosae Rugosae extract form, outside the Apple cell activity object
Surface is coated with phospholipid bilayer；Weight percent of the phospholipid bilayer in the Apple cell encapsulation object be
0.001%；
Weight percent of the Suo Shu Wen Quince leaf polyphenol extract in the Apple cell encapsulation object is 0.1%；
Weight percent of the Flos Rosae Rugosae extract in the Apple cell encapsulation object is 0.1%.
In the present embodiment, eryngium maritimum (ERYNGIUM MARITIMUM) the callus tissue culture filtrate be careless oil,
The mixture that borage oil and castor oil three are the ratio between by weight 1:1:1.
This has effects that the preparation method of anti-aging, the composition repaired, comprising the following steps:
Step 1: preparing Apple cell encapsulation object
The two is put into mixed dissolution in clear water by a) difference Cheng Qu Wen Quince leaf polyphenol extract and Flos Rosae Rugosae extract,
The weight ratio for obtaining extract solution , Suo Shu Wen Quince leaf polyphenol extract, the Flos Rosae Rugosae extract and the clear water is 1:
1:20；
B) the Apple cell activity object for weighing the dewatering state of formula ratio respectively throws the apple cells active matter
Enter into above-mentioned extraction solution and impregnate 2~3h, so that imbitition occurs for the Apple cell activity object, obtains imbibition
The weight ratio of apple cells active matter, the Apple cell activity object and the extract solution is 1:10；
C) water extra in imbibition apple cells active matter is filtered out, using phosphatidyl choline and imbibition apple cells active matter
0.5h is mixed under room temperature, and one layer of phospholipid bilayer rouge is then made in imbibition apple cells activity exterior surface by film dispersion method
Plastid；
Step 2: preparation anti-aging remediation composition
A) Apple cell encapsulation object, rose (ROSA SPP.) extract, hexapeptide -11, palmityl of formula ratio are weighed
Tripeptides -1, palmityl tetrapeptide -7, dipeptides diaminobutyryl benzyl amide diacetin, eryngium maritimum (ERYNGIUM
MARITIMUM) callus tissue culture filtrate and emulsifier；
B) first by the rose (ROSA SPP.) extract, hexapeptide -11, palmityl tripeptides -1, palmityl tetrapeptide -7, two
Peptide diaminobutyryl benzyl amide diacetin, eryngium maritimum (ERYNGIUM MARITIMUM) callus tissue culture filtrate and
Emulsifier, which is put into, mixes slowly 2h under room temperature in batch mixer, the Apple cell encapsulation object is then slowly added into institute
It states in batch mixer, continues to mix slowly 0.5h, anti-aging, remediation composition is made.
Embodiment 3 (preparation of anti-aging remediation composition)
A kind of composition for having effects that anti-aging, repairing, including following components in percentage by weight:
Apple cell encapsulation object 8.0%；Rose (ROSA SPP.) extract 0.5%, hexapeptide -11 0.004%；Palm fibre
Palmitic acid acyl tripeptides -1 0.4%；Palmityl tetrapeptide -7 0.4%, eryngium maritimum (ERYNGIUM MARITIMUM) callus tissue culture
Object filtrate 2.596%；Emulsifier 0.6%.
In the present embodiment, the Apple cell encapsulation object is by Apple cell activity object and penetrates into the Apples
Real cell activity object Nei Wen Quince leaf polyphenol extract and Flos Rosae Rugosae extract form, outside the Apple cell activity object
Surface is coated with phospholipid bilayer；Weight percent of the phospholipid bilayer in the Apple cell encapsulation object be
0.0015%；
Weight percent of the Suo Shu Wen Quince leaf polyphenol extract in the Apple cell encapsulation object is 2%；
Weight percent of the Flos Rosae Rugosae extract in the Apple cell encapsulation object is 2%.
In the present embodiment, eryngium maritimum (ERYNGIUM MARITIMUM) the callus tissue culture filtrate be careless oil and
The two in castor oil is the mixture of 1:2 by weight.
In the present embodiment, the emulsifier is that both -20 polyol partial esters of polysorbate and amino acid are by weight
The mixture of 1:1.
This has effects that the preparation method of anti-aging, the composition repaired, comprising the following steps:
Step 1: preparing Apple cell encapsulation object
The two is put into mixed dissolution in clear water by a) difference Cheng Qu Wen Quince leaf polyphenol extract and Flos Rosae Rugosae extract,
The weight ratio for obtaining extract solution , Suo Shu Wen Quince leaf polyphenol extract, the Flos Rosae Rugosae extract and the clear water is 1:
1:25；
B) the Apple cell activity object for weighing the dewatering state of formula ratio respectively throws the apple cells active matter
Enter into above-mentioned extraction solution and impregnate 2~3h, so that imbitition occurs for the Apple cell activity object, obtains imbibition
The weight ratio of apple cells active matter, the Apple cell activity object and the extract solution is 1:13；
C) water extra in imbibition apple cells active matter is filtered out, using phosphatidyl choline and imbibition apple cells active matter
0.8h is mixed under room temperature, and one layer of phospholipid bilayer rouge is then made in imbibition apple cells activity exterior surface by film dispersion method
Plastid；
Step 2: preparation anti-aging remediation composition
A) Apple cell encapsulation object, hexapeptide -11, the dipeptides diaminobutyryl benzyl amide oxalic acid of formula ratio are weighed
Salt, eryngium maritimum (ERYNGIUM MARITIMUM) callus tissue culture filtrate and emulsifier；
B) first by the rose (ROSA SPP.) extract, hexapeptide -11, dipeptides diaminobutyryl benzyl amide oxalic acid
Salt, eryngium maritimum (ERYNGIUM MARITIMUM) callus tissue culture filtrate and emulsifier are put into batch mixer under room temperature
2.5h is mixed slowly, then the Apple cell encapsulation object is slowly added into the batch mixer, continues to mix slowly
Anti-aging, remediation composition is made in 0.8h.
Embodiment 4~6 (preparation of the cream of the remediation composition containing anti-aging)
The present invention contains the cosmetics cream of anti-aging remediation composition, see the table below 1 institute containing following component and dosage
Show.
Cosmetics cream component and content (weight percent %) of the table 1 containing anti-aging remediation composition
The preparation process of the cream of the present embodiment 4-6 is as follows:
1) A phase raw material is added in oily phase pot, 80~85 DEG C of agitating and heating dissolutions completely, are then added C phase anti-aging and repair
Compound composition 10% is kept the temperature spare；
2) B phase raw material is added in kettle, heating stirring to raw material is completely dissolved under 80 DEG C of temperature, heat preservation 10min sterilizing
After obtain B phase feedstock processing object, keep the temperature spare.
3) B phase feedstock processing object obtained in step 2) is pumped into emulsion pot, is pumped into A phase raw material under homogeneous stirring
In emulsion pot, starts to cool down after homogeneous 5min, stirring heat preservation 10min, discharge when temperature drops to 40 DEG C.
Embodiment 7 (preparation of the toner containing anti-aging remediation composition)
The present invention contains the toner of anti-aging remediation composition, see the table below shown in 2 containing following component and dosage.
Makeup water component and dosage (weight percent %) of the table 2 containing anti-aging remediation composition
Operating procedure is as follows:
It accurately weighs various raw materials in A, B phase, opens stirring, first put into A phase each component raw material, stirring is to being completely dissolved
Afterwards, B phase each component is added, after being completely dissolved, after stirring 20min, discharging.
Effete test embodiment (clinical trial)
It is mixed with lotion, is obtained containing the present composition by composition obtained by the embodiment 1 using 0.1%
Lotion (embodiment 4-6), which is used for clinical trial.
1, it releives measure of merit:
Lotion obtained above is applied to volunteer's face to test, volunteer is 20 ages from 44 years old to 67 years old
Women；After 28 days, is assessed by colorimetric measurement and resist rubescent effect and effect of releiving is assessed by prick test, observe will
Hope person's face resists rubescent and effect of releiving treatment.
As shown in Figure 1, rubescent to reduce 16% in 20 volunteers, stimulation decline 29%；And after treatment in 28 days,
90% women declares that skin is tranquil, and 85% women declares rubescent reduced, and 80% women declares skin not
Suitable to have declined, 75% women declares that dermoreaction (spot) significantly reduces, it is seen that the composition of the application has preferable
It releives effect, plays the effect of reparation.
2, anti-wrinkle effect is tested:
Lotion obtained above is applied to volunteer's face to test, volunteer is 20 ages from 44 years old to 67 years old
Women, observe the effect of volunteer crows feet area smooth out wrinkles, tested with UVA, detection in every seven days is primary, observes will
The anti-wrinkle effect of hope person.
Data as shown in Figure 2 can obtain, and be used continuously 7 days, wrinkle decrease rate is 6 times of placebo group, it is seen that this
The composition of invention has the effect of good crease-resistant, plays the role of anti-aging.
3, the release slip test of relaxation factor NO:
Be divided into 4 groups of endothelial cells, as shown in connection with fig. 3, the addition lotion amount of 4 groups of endothelial cells is 0 respectively, 0.1%,
0.2%, 0.5%, then carry out the test of UVA.The NO reduction amount for obtaining blank control group endothelial cells is minimum, and additive amount is
0.1%, nitric oxide (NO) the burst size difference of 0.2%, 0.3% 3 groups of endothelial cells is significant reduces by 19%, 25% He
33%.
As it can be seen that the composition of the application can reduce the reduction amount of relaxation factor NO, anti crease and anti senile old effect is played.
4, TNF-α ratio drawdown test:
It is divided into 5 groups of volunteers, as shown in connection with fig. 4, the concentration that preceding 4 groups of volunteers smear lotion obtained above is 0 respectively,
5 μ g/mL, 12.5 μ g/mL, 25 μ g/mL, last group of volunteer spread 39.2 μ g/mL dexamethasone, then carry out the survey of UVA
Examination.
As it can be seen that composition of the invention can reduce TNF-α, but the present composition reduce the effect of TNF-α not as good as
Sai meter Song, but still can illustrate that the present composition has anti-aging, the effect of reparation.
5, the test of interleukin-8 ratio decline:
It is divided into 5 groups of volunteers, as shown in connection with fig. 5, the concentration that preceding 4 groups of volunteers smear lotion obtained above is 0 respectively,
5 μ g/mL, 12.5 μ g/mL, 25 μ g/mL, last group of volunteer spread 39.2 μ g/mL dexamethasone, then carry out the survey of UVA
Examination.
As it can be seen that composition of the invention can reduce interleukin-8, and reach interleukin-8 ratio and decline in identical situation,
The addition concentration of composition of the invention is lower than dexamethasone, further illustrates the anti-aging of the present composition, the effect of reparation
Fruit.
6, the test of malonaldehyde ratio decline:
Be divided into 4 endothelial cells, as shown in connection with fig. 6, the addition lotion amount of 4 groups of endothelial cells is 0 respectively, 0.5%, 1%,
2.5%, by 4 groups of endothelial cells autoxidations, the malonaldehyde decline for obtaining blank control group endothelial cells is minimum, and additive amount
Malonaldehyde for 0.5%, 1%, 2.5% 3 groups of endothelial cells is reduced to 14%, 19% and 25%.
It can be seen that the composition of the application can reduce malonaldehyde, skin is protected not influenced by peroxidatic reaction of lipid, played
Anti-aging, the effect of reparation.
The above described is only a preferred embodiment of the present invention, be not intended to limit the present invention in any form, therefore
Without departing from the technical solutions of the present invention, to the above embodiments according to the technical essence of the invention any simply to repair
Change, equivalent variations and modification, all of which are still within the scope of the technical scheme of the invention.
Claims (10)
1. a kind of composition for having effects that anti-aging, repairing, which is characterized in that include following components in percentage by weight:
2. the composition for having effects that anti-aging as described in claim 1, repairing, it is characterised in that: the Apple is thin
Born of the same parents' wrappage is by Apple cell activity object and penetrates into the Apple cell activity object Nei Wen Quince leaf polyphenol extract
It is formed with Flos Rosae Rugosae extract；
The outer surface of the Apple cell activity object is coated with phospholipid bilayer, and the phospholipid bilayer is thin in the Apple
Weight percent in born of the same parents' wrappage is 0.001~0.002%；
Weight percent of the Suo Shu Wen Quince leaf polyphenol extract in the Apple cell encapsulation object is 0.1~5%；
Weight percent of the Flos Rosae Rugosae extract in the Apple cell encapsulation object is 0.1~5%.
3. the composition for having effects that anti-aging as described in claim 1, repairing, it is characterised in that: the eryngium maritimum is cured
Injured tissue culture filtrate is one of careless oil, borage oil and castor oil or any two or more mixture.
4. the composition for having effects that anti-aging as described in claim 1, repairing, it is characterised in that: the emulsifier is selected from
One of polyglyceryl fatty acid ester, alkyl poly glucoside, polyol partial esters and amino acid and peptides emulsifier or any two
Kind or more mixture.
5. the composition for having effects that anti-aging as claimed in claim 2, repairing, it is characterised in that:
The Apple cell activity object is the apple cells freeze-dried powder of NAOLYS company, France production；
The rose extract is the rose extract of NOLYS company, France production；
The hexapeptide -11 is the hexapeptide -11 of U.S. Active Concepts company production；
The palmityl tripeptides -1 are the palmityl tripeptides -1 of France Sederma production；
The palmityl tetrapeptide -7 is the palmityl tetrapeptide -7 of France Sederma production；
The dipeptides diaminobutyryl benzyl amide diacetin is the dipeptides diaminobutyryl benzyl of dutch royal DSM N. V. production
Base amide diacetin；
Suo Shu Wen Quince polyphenol leaf extract is BERKEM company, France Sheng Chan Wen Quince polyphenol leaf extract；
The Flos Rosae Rugosae extract is the Flos Rosae Rugosae extract of BERKEM company, France production；
The eryngium maritimum callus tissue culture filtrate is the eryngium maritimum callus of Biotech Marine company, France production
Tissue culture filtrate.
6. the preparation method with anti-aging, the composition repaired according to any one of claims 1 to 5, feature
It is, comprising the following steps:
A) Apple cell encapsulation object, rose extract 0.01~1.0%, hexapeptide -11, the dipeptides diamino of formula ratio are weighed
Butyryl benzyl amide diacetin, palmityl tripeptides -1, palmityl tetrapeptide -7, eryngium maritimum callus tissue culture filtrate and cream
Agent；
B) first by the rose extract 0.01~1.0%, hexapeptide -11, dipeptides diaminobutyryl benzyl amide diacetin, palm fibre
Palmitic acid acyl tripeptides -1, palmityl tetrapeptide -7, eryngium maritimum callus tissue culture filtrate and emulsifier are put into batch mixer, room temperature
Under mix slowly 2~3h, then the Apple cell encapsulation object is slowly added into the batch mixer, continuation stir at a slow speed
0.5~1h is mixed, the composition for having effects that anti-aging, repairing is made.
7. having effects that the preparation method of anti-aging, the composition repaired as claimed in claim 6, it is characterised in that:
The Apple cell encapsulation object is made by following processing step:
A) Cheng Qu Wen Quince leaf polyphenol extract and Flos Rosae Rugosae extract obtain mixed dissolution in the two investment clear water respectively
The weight ratio of extract solution , Suo Shu Wen Quince leaf polyphenol extract, the Flos Rosae Rugosae extract and the clear water is 1:1:20
~30；
B) the Apple cell activity object for weighing the dewatering state of formula ratio respectively, the apple cells active matter is put into
2~3h is impregnated in said extracted solution, so that imbitition occurs for the Apple cell activity object, it is thin to obtain imbibition apple
The weight ratio of cytoactive object, the Apple cell activity object and the extract solution is 1:10~15；
C) water extra in imbibition apple cells active matter is filtered out, using phosphatidyl choline and imbibition apple cells active matter room temperature
Then one layer of phospholipid bilayer rouge is made in imbibition apple cells activity exterior surface by film dispersion method in 0.5~1h of lower mixing
Plastid is Apple cell encapsulation object.
8. according to any one of claims 1 to 5 have effects that anti-aging, the composition repaired are preparing answering in cosmetics
With, it is characterised in that: it is described to have effects that anti-aging, the composition repaired account for the 0.3~20% of cosmetic formulations total amount.
9. having effects that anti-aging, the composition repaired are preparing the application in cosmetics, feature as claimed in claim 8
Be: the cosmetics further include customary adjuvant, and the customary adjuvant contains: deionized water, moisturizer, conditioner, thickener,
One of preservative, essence are a variety of.
10. have effects that anti-aging, the composition repaired are preparing the application in cosmetics as claimed in claim 8, it is special
Sign is: creme, emulsion, essence lotion or facial mask form is made in the cosmetics.
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| CN113786362A (en) * | 2021-09-26 | 2021-12-14 | 湖北省麦诗特生物科技有限公司 | Toning lotion composition with effects of relieving, balancing and protecting skin and preparation method thereof |
| CN113786378A (en) * | 2021-09-26 | 2021-12-14 | 湖北省麦诗特生物科技有限公司 | Toning lotion composition with effects of improving skin color and brightening skin and preparation method thereof |
| CN113893217A (en) * | 2021-11-12 | 2022-01-07 | 湖北省麦诗特生物科技有限公司 | Face cream composition with spot-fading effect and preparation method and application thereof |
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| CN113786362A (en) * | 2021-09-26 | 2021-12-14 | 湖北省麦诗特生物科技有限公司 | Toning lotion composition with effects of relieving, balancing and protecting skin and preparation method thereof |
| CN113786378B (en) * | 2021-09-26 | 2024-01-12 | 湖北省麦诗特生物科技有限公司 | Toning lotion composition with skin color improving and brightening effects and preparation method thereof |
| CN113893217A (en) * | 2021-11-12 | 2022-01-07 | 湖北省麦诗特生物科技有限公司 | Face cream composition with spot-fading effect and preparation method and application thereof |
| CN113893217B (en) * | 2021-11-12 | 2024-02-09 | 湖北省麦诗特生物科技有限公司 | Face cream composition with freckle-removing effect and preparation method and application thereof |
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