CN115844804A - Composition for improving exogenous aging and preparation method and application thereof - Google Patents
Composition for improving exogenous aging and preparation method and application thereof Download PDFInfo
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Abstract
The invention belongs to the field of cosmetics, and relates to a composition for improving exogenous aging, a preparation method and an application thereof, wherein the composition comprises the following components in parts by weight: 10-40 parts of sparassis crispa extract, 10-40 parts of plankton extract, 10-40 parts of rosa deserticola (Adenium OBESUM) leaf cell extract, 10-20 parts of marrubium vulgare extract and 10-20 parts of hydrolyzed yeast protein. In the composition for improving the exogenous aging, multiple components are organically combined and act together, the composition has the effects of repairing ultraviolet injury, resisting cold and heat aging, resisting oxidation, resisting pollution, regulating the circadian rhythm of skin and the like, can be used for accurately solving the exogenous aging brought by environment and bad work and rest in multiple directions, has the effects of improving the water content of the skin, brightening the skin color, reducing wrinkles, shrinking pores and improving the texture of the skin, is safe and non-irritant, and can be widely applied to the cosmetic industry.
Description
Technical Field
The invention belongs to the technical field of daily chemicals, and particularly relates to a composition for improving exogenous aging, and a preparation method and application thereof.
Background
Skin aging is a complex process, affected by both endogenous and exogenous factors. The human body and the environment are a close and inseparable whole, the skin is taken as the outermost organ of the human body and plays a role in protecting, feeling, regulating body temperature, excreting, immunizing and other aspects, and the skin is directly contacted with the external environment and is not challenged and invaded by environmental exposure factors all the time.
Skin aging is closely related to environmental exposure. Light and ROS (reactive oxygen species) cause DNA damage, apoptosis, and are major factors affecting skin aging, however, in addition, humans are exposed to increasingly extreme high temperatures, low temperatures, increasingly severe air pollution, and irregular overnight work and rest. In one day, the temperature of the skin can fluctuate by more than 20 ℃ along with the environment, so that physiological damage of the skin can be caused, and researches show that temperature aging can cause enzyme inactivation and protein damage; the increase of each 20.04 mug/m is proved by research 3 PM10 of (a) means an increase in pigment spots on the cheeks of 16% (Nakamura, 2015, huls, 2016); survey shows that people who have a habit of staying up at night and are irregular in sleeping have dry and rough skin, rough skin and easy eruption and make-upThe problems of poor effect and the like are respectively 1.4 times, 1.7 times and 1.7 times of people with regular sleeping time.
At present, a plurality of researches on improving skin aging are carried out, and the prior related technology for improving skin aging has the following defects:
1. mainly focuses on improving endogenous aging, however, endogenous factors are greatly influenced by genes, hormones and the like, and improvement in the cosmetic range is greatly restricted. Extrinsic aging of the skin is caused by several controllable factors and occurs with varying degrees of intensity. Therefore, the improvement of exogenous aging can achieve better effect to a great extent.
2. The human skin faces various environmental threats, and technologists have studied photoaging resistance and oxidation resistance, but the influence brought by systematically and comprehensively solving various environments and living habits is little.
3. The formula in the prior art has incomplete efficacy.
Therefore, the development of a product with complete anti-aging effects aiming at exogenous aging, complete target systems and complete effects is urgently needed.
Disclosure of Invention
In order to overcome the problems of the prior art, the invention provides a composition for improving exogenous aging, and a preparation method and application thereof.
The composition provided by the invention is complementary in action mechanism, and has the functions of resisting ultraviolet, cold and heat aging, oxidation and pollution, regulating skin rhythm and the like by combined application, so that the effects of improving the water content of skin, brightening the skin color, reducing wrinkles, shrinking pores and improving skin texture are achieved.
Meanwhile, the composition provided by the invention is simple in preparation process and strong in operability, the stability of the active ingredients can be maintained in the preparation process, the composition for improving exogenous aging is used for preparing cosmetics or skin care products, and when the cosmetics or the skin care products are used, the skin feel is fresh and easy to absorb, and stimulation cannot be brought to the skin.
The purpose of the invention can be realized by the following technical scheme:
the invention firstly provides a composition for improving exogenous aging, which comprises the following components in parts by weight: 10-40 parts of sparassis crispa extract, 10-40 parts of plankton extract, 10-40 parts of rosa deserticola (Adenium OBESUM) leaf cell extract, 10-20 parts of marrubium vulgare extract and 10-20 parts of hydrolyzed yeast protein.
In a preferred embodiment of the present invention, the composition for improving extrinsic aging comprises the following components in parts by weight: 10 parts of sparassis crispa extract, 40 parts of plankton extract, 20 parts of desert rose leaf cell extract, 10 parts of marrubium vulgare extract and 20 parts of hydrolyzed yeast protein.
In a preferred embodiment of the present invention, the composition for improving extrinsic aging comprises the following components in parts by weight: 40 parts of sparassis crispa extract, 20 parts of plankton extract, 10 parts of desert rose leaf cell extract, 20 parts of marrubium vulgare extract and 10 parts of hydrolyzed yeast protein.
In a preferred embodiment of the present invention, the composition for improving extrinsic aging comprises the following components in parts by weight: 30 parts of sparassis crispa extract, 30 parts of plankton extract, 15 parts of desert rose leaf cell extract, 15 parts of marrubium vulgare extract and 10 parts of hydrolyzed yeast protein.
In an embodiment of the present invention, in addition to the sparassis crispa extract, plankton extract, desert rose leaf cell extract, marrubium vulgare extract, and hydrolyzed yeast protein, the composition for improving exogenous aging may further include a solvent and an auxiliary material, wherein the solvent is allowed to be used in cosmetics or skin care products, the solvent may be, for example, water, glycerin, and the auxiliary material may be, for example, one or more of a surfactant, a thickener, a conditioner, a humectant, a preservative, and a chelating agent.
In the invention, the sparassis crispa extract contains veratric acid, a certain amount of beta-glucan, vitamin C and vitamin E. The content of veratric acid in the sparassis crispa extract is in a certain relation with the specific obtaining mode of the sparassis crispa extract, and the content of the veratric acid in the sparassis crispa extract is generally within the range of 1000-6000 ppm. For the purposes of this application, sparassis crispa extract with veratric acid in the range of 5000ppm to 6000ppm is preferred.
In one embodiment of the present invention, the preparation method of the sparassis crispa extract comprises: adding purified water into Sparassis crispa mycelium, shaking, mixing, shearing at high speed, extracting at high temperature, centrifuging to obtain supernatant, and concentrating under reduced pressure to obtain Sparassis crispa extract containing 1000-6000ppm of veratric acid, a certain amount of beta-dextran, vitamin C, and vitamin E.
In the preparation process of the sparassis crispa extract, sparassis crispa mycelium is added into purified water according to the material-liquid ratio of 1.
In the present invention, the plankton extract contains diguanosine tetraphosphate (GP 4G nucleotide).
In one embodiment of the present invention, the preparation method of the plankton extract comprises: adding purified water into polar plankton to obtain suspension, grinding, extracting, centrifuging, filtering, and pasteurizing at low temperature to obtain plankton extract containing guanosine tetraphosphate (GP 4G nucleotide).
In the preparation process of the plankton extract, the polarity-phagocytic plankton is added into purified water according to the feed-liquid ratio of 1.
In one embodiment of the present invention, the preparation method of the desert rose leaf cell extract comprises: selecting desert rose leaves to generate callus, carrying out biological amplification after suspension proliferation, obtaining cell suspension after purification, extracting, filtering and sterilizing.
In the invention, the marrubiin extract contains active ingredient forsythiaside B, the content of the forsythiaside B in the marrubiin extract has a certain relation with the specific obtaining mode of the marrubiin extract, and the content of the forsythiaside B in the marrubiin extract is generally within the range of 200-600 ppm. For the purposes of the present application, an extract of marrubium vulgare with a forsythoside B content in the range from 300ppm to 600ppm (e.g. selected to be 350 ppm) is preferred.
In one embodiment of the present invention, the marrubium vulgare extract is prepared by the following steps: selecting leaf of marrubium vulgare to generate callus, performing suspension proliferation, performing biological amplification, purifying to obtain cell suspension, and extracting by extraction process to obtain the extract containing 200-600ppm of forsythiaside B active ingredient.
In one embodiment of the invention, the hydrolysed yeast protein is derived from hydrolysates of plants such as wheat (triticum monococcum), potato (Solanum tuberosum), maize (Zea mayz l.) or pea (Pisum sativum) or from yeasts of the saccharomyces genus, obtained by fermentation techniques. The hydrolyzed yeast protein is purified and contains peptides with molecular weight less than 6 KDa.
The invention further provides a preparation method of the composition for improving the exogenous aging, which comprises the steps of fully mixing a certain amount of sparassis crispa extract, plankton extract, desert rose leaf cell extract, marrubium vulgare extract and hydrolyzed yeast protein, and uniformly stirring to prepare the composition for improving the exogenous aging.
In one embodiment of the present invention, the temperature of the mixing is 10 to 30 ℃ during the preparation of the composition for improving extrinsic aging. The stirring speed is 100-200r/min.
The invention further provides the application of the exogenous aging improving composition, the exogenous aging improving composition is used in the preparation of cosmetics or skin care products, and the cosmetics or the skin care products comprise 0.01-50 percent of the exogenous aging improving composition based on the total weight of the cosmetics or the skin care products; and 50-99.99% of solvent and adjuvants for cosmetic or skin care product; preferably, the cosmetic or skin care product comprises 0.01-30% of the exogenous senescence-ameliorating composition; and 70-99.99% of solvent and adjuvants for cosmetic or skin care product. In one embodiment of the present invention, the adjuvant comprises one or more of a surfactant, a thickener, a conditioner, a humectant, a preservative, and a chelating agent. The solvent includes deionized water, glycerin, etc.
In one embodiment of the invention, the cosmetic or skin care product is made into various cosmetics or skin care products such as an anti-aging facial cleanser, an anti-aging cream, an anti-aging emulsion, an anti-aging lotion, an anti-aging mask, an anti-aging eye cream or an anti-aging gel.
The present invention still further provides a cosmetic or skin care preparation for improving extrinsic aging, comprising 0.01 to 50% of an extrinsic aging-improving composition, based on the total weight of the cosmetic or skin care preparation; and 50-99.99% of solvent and adjuvants for cosmetic or skin care product.
In one embodiment of the invention, the skin care product for improving extrinsic aging is an aging delaying emulsion, and the aging delaying emulsion comprises the following raw material components in percentage by weight: 0.01-50% of composition for improving exogenous aging, 0.2% of xanthan gum, 3% of 1, 3-butanediol, 2% of glycerol, 0.2% of trehalose, 0.05% of EDTA-2Na, 0.4% of p-hydroxyacetophenone, 0.4% of 1, 2-hexanediol and the balance of deionized water. Preferably, the raw material components of the aging-delaying emulsion comprise: 0.01-30% of composition for improving exogenous aging, 0.2% of xanthan gum, 3% of 1, 3-butanediol, 2% of glycerol, 0.2% of trehalose, 0.05% of EDTA-2Na, 0.4% of p-hydroxyacetophenone, 0.4% of 1, 2-hexanediol and the balance of deionized water. The senescence-delaying emulsion may comprise 0.01%,1%,5%,10%,15%,20%,25%,30%, etc. of the composition for improving exogenous senescence.
Further, the anti-aging emulsion is prepared by the following method:
pre-dispersing 1, 3-butanediol, EDTA-2Na and xanthan gum uniformly, adding into deionized water, and stirring until completely dissolved; adding trehalose at 200-400r/min, stirring to disperse uniformly, heating to 80-90 deg.C, adding p-hydroxyacetophenone, stirring uniformly, and stopping heating after completely dissolving; cooling to 38-42 ℃, adding the composition for improving exogenous senescence, uniformly stirring glycerol and 1, 2-hexanediol, adding into the system, uniformly stirring, discharging and subpackaging to obtain the emulsion for delaying senescence.
Compared with the prior art, the invention has the beneficial effects that:
1) The composition for improving the exogenous aging provided by the invention simultaneously comprises the Sparassis crispa extract, the plankton extract, the desert rose leaf cell extract, the marrubium vulgare extract and the hydrolyzed yeast protein, and the components are jointly applied to have the functions of resisting ultraviolet rays, cold and heat aging, oxidation and pollution and regulating the rhythm of the skin, so that the problem of the exogenous aging is solved comprehensively, and the multiple effects of improving the water content of the skin, brightening the skin color, reducing wrinkles, shrinking pores and improving the texture of the skin are achieved.
2) The composition for improving the extrinsic aging, provided by the invention, has the advantages of simple preparation process and strong operability, the stability of the active ingredients can be maintained in the preparation process, the composition for improving the extrinsic aging is used for preparing cosmetics or skin care products, and when the cosmetics or the skin care products are used, the skin feel is fresh and easy to absorb, and no stimulation is brought to the skin. Therefore, the method has important practical significance and wide market prospect.
Drawings
FIG. 1 is a facial texture improvement profile of the exogenous senescence-improving composition provided by the invention.
FIG. 2 is a facial wrinkle improvement chart of the composition for improving extrinsic aging according to the present invention.
FIG. 3 is a graph showing the improvement of facial complexion with the exogenous senescence-improving composition of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It should be apparent that the described embodiments are only some embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without any inventive step, are within the scope of the present invention.
The invention discloses a composition for improving exogenous aging, which comprises sparassis crispa extract, plankton extract, desert rose leaf cell extract, marrubium vulgare extract and hydrolyzed yeast protein.
The technical effects of the raw material components are described below.
The following focuses on the preparation method and efficacy description of each raw material component in the composition.
(1) Sparassis crispa extract
The preparation method comprises the following steps: weighing Sparassis crispa mycelium, adding purified water according to a material-liquid ratio of 1;
the efficacy is as follows: common mushrooms grow on the shady surface, while sparassis crispa needs more than 10h of irradiation every day and is the only 'sunshine mushroom' in the world. The Sparassis crispa extract contains 5000ppm veratric acid, and has effects of resisting photoaging, inhibiting UVB induced inflammation, and protecting UVB; the Sparassis crispa also has good effect of eliminating skin problems such as melanin precipitation and the like because of containing a large amount of beta glucan, antioxidant substances, vitamin C and vitamin E.
(2) Plankton extracts
The preparation method comprises the following steps: weighing polar plankton (such as blue algae or green algae), adding purified water according to a feed-liquid ratio of 1.
The efficacy is as follows: in the course of evolution, this plankton has been adapted to survive in the harsh environment of extreme temperatures, GP4G nucleotide is the core element of the whole adaptation system, and plankton can convert GP4G into ATP. The plankton extract can effectively protect cells from negative effects caused by cold shock and heat shock, and has the effect of relieving temperature aging.
(3) Desert rose leaf cell extract
The preparation method comprises the following steps: the Rosa desertorum leaf cell extract is prepared by selecting Rosa desertorum (Adenium OBESUM) leaf to generate callus (preferably Rosa desertorum), performing suspension proliferation, performing biological amplification, purifying to obtain cell suspension, extracting, filtering, and sterilizing.
The efficacy is as follows: desert roses, which prefer a high temperature dry and sunny environment, are resistant to intense summer heat and cold, are called desert roses because the origin is close to desert and red like roses. The rosa deserticola leaf cell extract has good antioxidant effect, can reduce the generation of free radicals, inhibit cell dysfunction caused by the free radicals, including skin dehydration and the like, and in addition, can prove to reduce lipid peroxidation translated by MDA.
(4) Marrubium vulgare L.var.ouye et Levl.C.extract
The preparation method comprises the following steps: the marrubium vulgare extract is forsythiaside B active ingredients with the concentration of 350ppm, which are extracted from the calluses generated by selecting marrubium vulgare leaves through an extraction process.
The efficacy is as follows: protecting skin cells from penetration of contaminants and gene disruption, clearance and neutralization of toxin oxides disrupts protein and lipid structures. Thereby helping to purify the skin, helping the skin to keep original fineness and preventing the complexion from becoming dull.
(5) Hydrolyzed yeast protein
The preparation method comprises the following steps: the hydrolyzed yeast protein is obtained from hydrolysate of plants such as wheat (Triticum monococcum), potato (Solanum tuberosum), corn (Zea mayz L.) or pea (Pisum sativum) or hydrolysate of yeast of Saccharomyces by fermentation technology. The hydrolyzed yeast protein is purified and contains peptides with molecular weight less than 6 KDa.
The efficacy is as follows: in 2017, nobel physiological or medical prize winners elucidated the molecular mechanisms that control circadian rhythms. A cell 'timing' beat, comparable to a metronome, is produced by a molecular oscillator involving the following CLOCK genes: CLOCK, BMAL, PER1, CRY. Human keratinocyte and human fibroblast experiments show that the hydrolyzed yeast protein effectively improves the expression of CLOCK, BMAL and PER1 genes, increases the expression of collagen III, has good cell synchronism, and effectively solves the skin problem caused by social contact time difference and insufficient sleep.
In the invention, the composition for improving the exogenous aging has the mutual combined action of various components through the difference of action mechanisms among the components, and particularly, the sparassis crispa extract mainly aims at photoaging, the plankton extract aims at cold and hot aging, the desert rose leaf cell extract aims at oxidative aging, the marrubium vulgare extract aims at aging caused by pollution, and the hydrolyzed yeast protein aims at aging caused by life styles such as irregular work and rest. The five active substances are complementary in action mechanism, action targets comprehensively cover common exogenous aging factors in life, and the combined application has the functions of resisting ultraviolet, cold and heat aging, oxidation and pollution, regulating skin rhythm and the like, so that the effects of improving skin water content, brightening skin color, reducing wrinkles, shrinking pores and improving skin texture are achieved, and the combined action is used for resisting aging. In addition, glycerin can be used as a humectant, and the composition for improving exogenous aging, which is finally prepared, has the effects of relieving the influence of environment and bad living habits on skin, improving the moisture content of the skin, brightening the skin color, reducing wrinkles, shrinking pores and improving the skin texture.
In the following examples, the unit of parts by weight may be g or kg.
Example 1
The embodiment provides an emulsion for improving exogenous aging, which comprises the following raw material components:
10% of composition for improving exogenous aging, 0.2% of xanthan gum, 3% of 1, 3-butanediol, 2% of glycerol, 0.2% of trehalose, 0.05% of EDTA-2Na, 0.4% of p-hydroxyacetophenone, 0.4% of 1, 2-hexanediol and the balance of deionized water.
Wherein the composition comprises the following raw material components in percentage by total weight of the composition for improving exogenous aging:
10 parts of sparassis crispa extract, 40 parts of plankton extract, 20 parts of desert rose leaf cell extract, 10 parts of marrubium vulgare extract and 20 parts of hydrolyzed yeast protein.
The emulsion for improving exogenous aging is prepared by the following method:
1, 3-butanediol, EDTA-2Na and xanthan gum are pre-dispersed uniformly, and then added into deionized water to be stirred until the materials are completely dissolved; adding trehalose at 300r/min, stirring to disperse uniformly, heating to 85 deg.C, adding p-hydroxyacetophenone, stirring uniformly, and stopping heating after completely dissolving; cooling to 40 ℃, adding the composition for improving exogenous aging, stirring uniformly glycerol and 1, 2-hexanediol, adding into the system, stirring uniformly, discharging and packaging to obtain the emulsion for improving exogenous aging.
Example 2
The embodiment provides an exogenous aging improving emulsion, which comprises the following raw material components:
10% of composition for improving exogenous aging, 0.2% of xanthan gum, 3% of 1, 3-butanediol, 2% of glycerol, 0.2% of trehalose, 0.05% of EDTA-2Na, 0.4% of p-hydroxyacetophenone, 0.4% of 1, 2-hexanediol and the balance of deionized water.
Wherein the raw material components of the composition comprise the following components in percentage by total weight of the composition for improving exogenous aging:
40 parts of sparassis crispa extract, 20 parts of plankton extract, 10 parts of desert rose leaf cell extract, 20 parts of marrubium vulgare extract and 10 parts of hydrolyzed yeast protein.
The emulsion for improving exogenous aging is prepared by the following method:
pre-dispersing 1, 3-butanediol, EDTA-2Na and xanthan gum uniformly, adding into deionized water, and stirring until completely dissolved; adding trehalose at 300r/min, stirring to disperse uniformly, heating to 85 deg.C, adding p-hydroxyacetophenone, stirring uniformly, and stopping heating after completely dissolving; cooling to 40 ℃, adding the exogenous aging improving composition, uniformly stirring glycerol and 1, 2-hexanediol, adding into the system, uniformly stirring, discharging and packaging to obtain the exogenous aging improving emulsion.
Example 3
The embodiment provides an emulsion for improving exogenous aging, which comprises the following raw material components:
10% of composition for improving exogenous aging, 0.2% of xanthan gum, 3% of 1, 3-butanediol, 2% of glycerol, 0.2% of trehalose, 0.05% of EDTA-2Na, 0.4% of p-hydroxyacetophenone, 0.4% of 1, 2-hexanediol and the balance of deionized water.
Wherein the composition comprises the following raw material components in percentage by total weight of the composition for improving exogenous aging:
30 parts of sparassis crispa extract, 30 parts of plankton extract, 15 parts of desert rose leaf cell extract, 15 parts of marrubium vulgare extract and 10 parts of hydrolyzed yeast protein.
The emulsion for improving exogenous aging is prepared by the following method:
pre-dispersing 1, 3-butanediol, EDTA-2Na and xanthan gum uniformly, adding into deionized water, and stirring until completely dissolved; adding trehalose at 300r/min, stirring to disperse uniformly, heating to 85 deg.C, adding p-hydroxyacetophenone, stirring uniformly, and stopping heating after completely dissolving; cooling to 40 ℃, adding the composition for improving exogenous aging, stirring uniformly glycerol and 1, 2-hexanediol, adding into the system, stirring uniformly, discharging and packaging to obtain the emulsion for improving exogenous aging.
Comparative example
The following comparative examples are different from examples 1 to 3 only in the composition of the exogenous senescence-improving composition in the starting materials of the exogenous senescence-improving emulsion, and the amounts of other starting materials and the preparation method are the same as those in example 1.
TABLE 1 compositions of compositions for improving extrinsic aging in comparative examples 1 to 6
Test example for Effect verification
1. Test method
1. The tester: 187 healthy women (23-45 years old, average age 34.6 years old) randomly divided into 9 groups, each group comprising 21 persons (1 withdrawal test in the middle of comparative example 4 and comparative example 6, actual 20 persons, and 21 persons in other groups), with unlimited character, and preferably with living work affected by exogenous factors; each group used the same formulation. Test results the values in tables 2-6 are the average of 21 or 20 persons per group.
2. And (3) testing time: winter (relatively low temperature and poor air quality in one year)
3. Test area: in the visia full-face test, the C-CUBE test area is the intersection point (left side) of the outer canthus and the lower part of the alar, and the moisture content test area is the intersection point (right side) of the outer canthus and the lower part of the alar.
4. The using method comprises the following steps: the face lotion is used for whole face, is applied once after face washing in the morning and evening, and is continuously used for 4 weeks, so that outdoor insolation is avoided.
5. And (3) testing conditions are as follows: the subjects were rested for 30min at a temperature of 21 + -1 deg.C, relative humidity of 50 + -5% RH and tested silently.
6. Testing the instrument: visia7 facial photography system (Canfield, USA), C-Cube (PIXIENCE), water content tester (DELFIND, finland).
7. The effect indexes are as follows:
visia7 was used for facial image acquisition and analysis of 8 indicators of skin (spots, wrinkles, texture, pores, uv spots, brown spots, red areas, purple).
Cube carries out the portable integrated system that 3D measured through photometric stereo survey. The improvement of skin smoothness, glossiness and brightness is characterized by collecting 2D and 3D images of the skin and analyzing the indexes of the skin such as sdr, sa, sz, L, a, b, erythema, ITA, melanin and the like.
The moisture content tester measures the moisture content of the surface layer of the skin, and the higher the moisture content is, the better the skin is.
8. And (3) testing period: before use (D0), 28 days (D28)
9. Data processing: all results are the average of the results of 20 or 21 human subjects actually participating in the test.
2. Test results
1) Skin moisture content improves results
The skin moisture content was measured for the emulsions obtained in examples 1 to 3 and comparative examples 1 to 6. The results of human testing show that the skin moisture content increased by 33.55% after 28 days of use compared to that before use in cosmetic example 3 of the present invention (Table 2), indicating that the composition of the present invention has the effects of moisturizing and improving skin moisture content in cosmetic applications.
TABLE 2 skin moisture content improvement effect using 28 days
Description of the data: a positive improvement in moisture content indicates improved skin moisture content. And comparing examples 1-3 with comparative examples 1-6, it can be seen that the skin moisture contents of examples 1,2, and 3 of the present invention (i.e., containing simultaneously sparassis crispa extract, plankton extract, desert rose leaf cell extract, marrubium vulgare extract, hydrolyzed yeast protein) are better than those of comparative examples containing only 1-4 of the five components. It can be seen that the composition for improving exogenous aging provided by the invention simultaneously comprises sparassis crispa extract, plankton extract, desert rose leaf cell extract, marrubium vulgare extract and hydrolyzed yeast protein, and the combined application of the components has a synergistic effect.
2) Skin color improvement results
The emulsions obtained in the examples and comparative examples were subjected to skin color test using a C-Cube (PIXIENCE) apparatus. The test area is the intersection (random side) of the external canthus and the inferior part of the alar.
Wherein Table 3 shows the results of skin color improvement after 28 days of use by the testers of examples 1 to 3 and comparative examples 1 to 6.
The improvement in skin color of the face before and after the use of the emulsion obtained in example 3 was shown in FIG. 3, and the improvement in skin color of the face before and after the use for 28 days was shown in FIG. 3, and it was found that the skin color brightness was increased and the redness was reduced after the use for 28 days.
L of the subjects before and after the 28 th day using the products of examples and comparative examples was measured by C-Cube * 、a * 、b * The ITA DEG values, and the improvement rates were calculated, see Table 3.
Using example 1 as an example, L was tested in the first 21 subjects * 、a * 、b * The average ITA degrees are 57.919, 10.879, 11.547 and 35.346 respectively.
Subject L28 days after using the emulsion of example 1 * 、a * 、b * The average ITA ° values were 58.510, 10.219, 11.187, and 36.424, respectively.
L * 、a * 、b * The ITA degree improvement rates are +1.02%, -6.07%, -3.12%, +3.05%, respectively.
Table 3 skin color improving effect using 28 days
Referring to table 3, the results of human body examination showed that the cosmetics according to examples 1,2 and 3 and comparative examples 1 to 6 of the present invention had increased skin brightness L, decreased red color a, decreased yellow color b, and increased brightness ITA ° after 28 days of use, indicating that the cosmetics according to examples 1,2 and 3 and comparative examples 1 to 6 of the present invention all had the effect of lightening skin color. However, the skin color lightening efficacy of examples 1,2 and 3 (i.e., containing simultaneously Sparassis crispa extract, plankton extract, rosa desertorum leaf cell extract, marrubium vulgare extract, hydrolyzed yeast protein) was better than that of comparative examples 1 and 2 containing four of them and better than that of comparative examples 3 and 4 containing three of them, while comparative example 5 containing only two of them had poor skin color lightening efficacy and comparative example 6 containing only one of them had the worst skin color lightening efficacy. It can be seen that the composition for improving exogenous aging provided by the invention simultaneously comprises sparassis crispa extract, plankton extract, desert rose leaf cell extract, marrubium vulgare extract and hydrolyzed yeast protein, and the combined application of the components has a synergistic effect.
3) Wrinkle improvement results
The emulsions obtained in the examples and comparative examples were subjected to wrinkle testing using a C-Cube (PIXIENCE) and Visia7 facial photographing System (Canfield, USA) apparatus.
Wherein Table 4 shows the results of 28-day wrinkle improvement in the test subjects of examples 1 to 3 and comparative examples 1 to 6.
On one subject, facial wrinkle improvement before and after use of the emulsion obtained in example 3 is shown in fig. 2, and the forehead wrinkles are improved before and after 28 days of use in fig. 2, respectively, with dark green representing significant wrinkles and light green representing fine wrinkles, and a significant reduction in the head-up lines can be seen after 28 days of use.
The number of periocular wrinkles, external canthus wrinkle depth, facial wrinkle score of the subjects before and after the 28 th day using the products of examples and comparative examples were measured by an instrument and the improvement rate was calculated, see table 4.
Taking example 1 as an example, the average values of periocular wrinkles, external canthus wrinkles depth and facial wrinkles score of the first 21 subjects tested were 34.198, 50.813 μm and 21.227, respectively.
The number of periocular wrinkles, external canthus wrinkles depth, facial wrinkle score averages 26.938 strips, 42.820 μm, 15.997, respectively, after 28 days of the subjects' use of the emulsion of example 1.
The improvement rates of the number of the peripheral wrinkles, the depth of the external canthus wrinkles and the facial wrinkle values are respectively-21.23%, -15.73%, -24.64%.
TABLE 4 skin wrinkle improvement effect using 28 days
As can be seen from the data in Table 4, the number of periocular wrinkles and the depth of wrinkles, as well as the facial wrinkle score were improved after 28 days using the cosmetics of examples 1 to 3 and comparative examples 1 to 6, indicating that the composition of the present invention has an effect of improving wrinkles in cosmetic applications. And comparing examples 1 to 3 with comparative examples 1 to 6, it can be seen that examples 1,2 and 3 of the present invention (i.e., containing simultaneously sparassis crispa extract, plankton extract, desert rose leaf cell extract, marrubium vulgare extract, hydrolyzed yeast protein) had better wrinkle-improving effects than the comparative examples containing only 1 to 4 of the five components. It can be seen that the composition for improving exogenous aging provided by the invention simultaneously comprises sparassis crispa extract, plankton extract, desert rose leaf cell extract, marrubium vulgare extract and hydrolyzed yeast protein, and the combined application of the components has a synergistic effect.
4) Pore texture improvement results
The emulsions obtained in the examples and comparative examples were subjected to pore and texture tests using a Visia7 facial photography system (Canfield, USA) and a C-Cube (PIXIENCE) apparatus, with the Visia7 test area being the full face and the C-Cube test area being the intersection of the external canthus and the underside of the alar (random side). Wherein Table 5 shows the results of the 28 day pore and texture improvement in the test subjects of examples 1-3 and comparative examples 1-6.
The improvement in facial texture before and after use of the emulsion obtained in example 3 was shown in fig. 1, and the improvement in facial texture before and after use for 28 days in fig. 1 is shown in the left and right of the figure, respectively, and the texture is an index for measuring the evenness and smoothness of skin color. The skin became more smooth and more uniform with 28 days of use, as judged by the gradual change in skin color and the peaks on the skin surface, yellow for the prominent areas and blue for the depressed areas (yellow peaks and blue valleys).
Pore score, texture score, purple score, skin Sa value of the subjects before and after 28 days using the products of examples and comparative examples were measured by the instrument and the improvement rate was calculated, see table 5.
Taking example 1 as an example, the pore score, texture score, purple score, and skin Sa value mean values of 16.961, 5.236, 16.334, and 5.234 μm were obtained for the first 21 subjects.
The average pore score, texture score, purple score and skin Sa value of the subjects after 28 days using the emulsion of example 1 were 14.093, 4.111, 13.103 and 3.745 μm, respectively.
The pore score, texture score, purple score and skin Sa value improvement rate are respectively-16.91%, -21.49%, -19.78%, -28.45%.
TABLE 5 skin pore and texture Effect using 28 days
As can be seen from the data in Table 5, the pores and texture were improved after 28 days using the cosmetics of examples 1-3 and comparative examples 1-6, indicating that the composition of the present invention has the effect of improving the pores and texture in cosmetic applications. And comparing examples 1 to 3 with comparative examples 1 to 6, it can be seen that examples 1,2 and 3 of the present invention (i.e., containing simultaneously Sparassis crispa extract, plankton extract, desert rose leaf cell extract, marrubium vulgare extract, hydrolyzed yeast protein) are superior in the effect of improving pores and texture to those of the comparative examples containing only 1 to 4 of the five components. It can be seen that the composition for improving exogenous aging provided by the invention simultaneously comprises sparassis crispa extract, plankton extract, desert rose leaf cell extract, marrubium vulgare extract and hydrolyzed yeast protein, and the combined application of the components has a synergistic effect.
5) Consumer satisfaction investigation results
Consumer satisfaction investigations were collected in the form of questionnaires, with the alleged acceptance in this test using a 5-point method, i.e.: score 1 to 5, score 1 unsatisfactory, score 2 less satisfactory, score 3 general, score 4 more satisfactory, and score 5 satisfactory. Satisfaction = score ≥ 4 divided subject population ÷ total effective population × 100%. According to the literature guidance of the method source, the test result requires that the tested consumer approves that the percentage is more than 50 percent, and the corresponding declaration can be supported.
Table 6 self-assessment (satisfaction) of subjects after 28 days of use
As can be seen from Table 6, the extrinsic aging improving emulsions obtained in examples 1 to 3 of the present invention and comparative examples 1 to 6 have the effects of improving skin moisture content, lightening skin color, reducing wrinkles, reducing pores, and improving skin texture, while the products are mild and non-irritating. And comparing examples 1-3 with comparative examples 1-6, it can be seen that examples 1,2, and 3 of the present invention (i.e., containing simultaneously Sparassis crispa extract, plankton extract, rosa desertorum leaf cell extract, marrubium vulgare extract, hydrolyzed yeast protein) have better effects of improving skin moisture content, lightening skin color, reducing wrinkles, reducing pores, and improving skin texture than comparative examples containing only 1-4 of the five components. It can be seen that the composition for improving exogenous aging provided by the invention simultaneously comprises sparassis crispa extract, plankton extract, desert rose leaf cell extract, marrubium vulgare extract and hydrolyzed yeast protein, and the combined application of the components has a synergistic effect. And the mild non-stimulation score of the product with the hydrolyzed yeast protein added in the comparative example 6 is not 100 percent, but only 95 percent, and further shows that the synergistic effect of various components is better and the stimulation is reduced.
In conclusion of the instrumental efficacy test and the consumer self-evaluation survey, the composition for improving the exogenous aging is specially designed for the exogenous aging, and has the effects of improving the moisture content of skin, brightening the skin color, reducing wrinkles, shrinking pores and improving the skin texture.
The embodiments described above are described to facilitate an understanding and use of the invention by those skilled in the art. It will be readily apparent to those skilled in the art that various modifications to these embodiments may be made, and the generic principles described herein may be applied to other embodiments without the use of the inventive faculty. Therefore, the present invention is not limited to the above embodiments, and those skilled in the art should make improvements and modifications within the scope of the present invention based on the disclosure of the present invention.
Claims (10)
1. The composition for improving the exogenous aging is characterized by comprising the following components in parts by weight: 10-40 parts of sparassis crispa extract, 10-40 parts of plankton extract, 10-40 parts of desert rose leaf cell extract, 10-20 parts of marrubium vulgare extract and 10-20 parts of hydrolyzed yeast protein.
2. The composition for improving the exogenous aging according to claim 1, wherein the composition for improving the exogenous aging comprises the following components in parts by weight: 10 parts of sparassis crispa extract, 40 parts of plankton extract, 20 parts of desert rose leaf cell extract, 10 parts of marrubium vulgare extract and 20 parts of hydrolyzed yeast protein; or the like, or, alternatively,
the composition for improving the exogenous aging comprises the following components in parts by weight: 40 parts of sparassis crispa extract, 20 parts of plankton extract, 10 parts of desert rose leaf cell extract, 20 parts of marrubium vulgare extract and 10 parts of hydrolyzed yeast protein; or the like, or a combination thereof,
the composition for improving the exogenous aging comprises the following components in parts by weight: 30 parts of sparassis crispa extract, 30 parts of plankton extract, 15 parts of desert rose leaf cell extract, 15 parts of marrubium vulgare extract and 10 parts of hydrolyzed yeast protein.
3. The composition for improving the exogenous aging according to claim 1 or 2, wherein the composition for improving the exogenous aging comprises a solvent selected from water or glycerol or a combination of the two in addition to the Sparassis crispa extract, the plankton extract, the Rosa desertorum leaf cell extract, the marrubium vulgare extract and the hydrolyzed yeast protein.
4. The composition for improving exogenous aging according to claim 1 or 2, wherein the Sparassis crispa extract contains veratric acid, β -glucan, vitamin C, vitamin E;
the plankton extract contains guanosine tetraphosphate;
the marrubium vulgare extract contains forsythoside B as active ingredient.
5. The method for preparing a composition for improving exogenous aging according to claim 1 or 2, wherein the composition for improving exogenous aging is prepared by mixing a certain amount of Sparassis crispa extract, plankton extract, rosa desertorum leaf cell extract, marrubium vulgare extract, and hydrolyzed yeast protein thoroughly in proportion, and stirring them uniformly.
6. Use of the extrinsic aging-ameliorating composition according to claim 1 or 2, characterized in that the extrinsic aging-ameliorating composition is used in the preparation of a cosmetic or dermatological product comprising from 0.01 to 50% of the extrinsic aging-ameliorating composition, based on the total weight of the cosmetic or dermatological product; and 50-99.99% of solvent and adjuvants for cosmetic or skin care product.
7. The use of claim 6, wherein the adjuvant comprises one or more of a surfactant, a thickener, a conditioner, a humectant, a preservative, and a chelating agent;
the solvent comprises deionized water and glycerol.
8. The use according to claim 6, wherein the cosmetic or skin care product is formulated as a senescence delaying facial cleanser, a senescence delaying facial cream, a senescence delaying lotion, a senescence delaying mask, a senescence delaying eye cream, or a senescence delaying gel.
9. A cosmetic or skin care product for ameliorating extrinsic aging, characterized in that the cosmetic or skin care product comprises 0.01 to 50% by weight of the extrinsic aging ameliorating composition of claim 1 or 2; and 50-99.99% of solvent and adjuvants for cosmetic or skin care product.
10. The cosmetic or skin care product for improving the extrinsic aging according to claim 9, wherein the skin care product for improving the extrinsic aging is an aging-delaying emulsion, and the aging-delaying emulsion comprises the following raw material components in percentage by weight: 0.01-50% of composition for improving exogenous aging, 0.2% of xanthan gum, 3% of 1, 3-butanediol, 2% of glycerol, 0.2% of trehalose, 0.05% of EDTA-2Na, 0.4% of p-hydroxyacetophenone, 0.4% of 1, 2-hexanediol and the balance of deionized water.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN117180163A (en) * | 2023-11-08 | 2023-12-08 | 北京尧景基因技术有限公司 | Extraction method of desert rose callus vesicles and application of desert rose callus vesicles in preparation of skin whitening products |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN117180163A (en) * | 2023-11-08 | 2023-12-08 | 北京尧景基因技术有限公司 | Extraction method of desert rose callus vesicles and application of desert rose callus vesicles in preparation of skin whitening products |
| CN117180163B (en) * | 2023-11-08 | 2024-01-30 | 北京尧景基因技术有限公司 | Extraction method of desert rose callus vesicles and application of desert rose callus vesicles in preparation of skin whitening products |
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