CN113081924A - Antioxidant composition, preparation method and application - Google Patents
Antioxidant composition, preparation method and application Download PDFInfo
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Abstract
The invention relates to the field of skin care products, and particularly discloses an antioxidant composition, a preparation method and application, wherein the antioxidant composition comprises the following components in parts by weight: 0.5-2 parts of tamarix chinensis flower extract; or 0.5-2 parts of tamarix chinensis leaf extract; and 2-4 parts of purslane extract. The invention inhibits the activity of free radical producing active enzyme through the extract of the Chinese tamarisk flowers or the extract of the Chinese tamarisk leaves, thereby inhibiting the generation of free radicals and inhibiting lipid oxidation. Preventing the reaction of the free radical with intracellular carbohydrate, protein, lipid and other matter to damage human body's cell and promote cell senility. The purslane extract has the effects of resisting allergy, inflammation and resisting various external irritations to skin, so that the antioxidant prepared by the invention has better antioxidant effect and more functions.
Description
Technical Field
The invention relates to the field of skin care products, in particular to an antioxidant composition, a preparation method and application.
Background
The human body carries out metabolic reaction all the time, free radicals generated by the metabolism of the organism generally play a role in electron transfer, and simultaneously have extremely strong oxidation capacity, but when the content of the free radicals in the human body is unbalanced, the free radicals react with substances such as intracellular carbohydrates, proteins, lipids and the like to damage the cells in the human body, so that the cells are accelerated to age. The attack and destroy of free radicals to normal cells are the main causes of human diseases and aging acceleration. The more the free radicals accumulate in each part of the human body, the faster the aging process of each part is, the more free skin cells are, the skin begins to be dry and has no elasticity, and wrinkles and senile plaques appear on the face. The antioxidant can effectively eliminate free radicals and effectively prevent series diseases caused by the free radicals.
Since antioxidants commonly used in the market contain most chemical components, the safety and effect of the components have been concerned, and therefore, the development of a mild and effective antioxidant is an urgent problem to be solved.
Disclosure of Invention
The invention aims to provide an antioxidant composition, a preparation method and application thereof, and aims to solve the problem that the existing antioxidant on the market is poor in safety and antioxidant effect.
In order to achieve the purpose, the invention adopts the following technical scheme:
the first purpose of the invention is to provide an antioxidant composition, which comprises the following components in parts by weight:
0.5-2 parts of tamarix chinensis flower extract; or
0.5-2 parts of tamarix chinensis leaf extract; and
2-4 parts of purslane extract.
Further, the antioxidant composition comprises the following components in parts by weight:
1.25 parts of tamarix chinensis flower extract; or
1.25 parts of tamarix chinensis leaf extract; and
2-4 parts of purslane extract.
Further, the antioxidant composition also comprises a humectant, wherein the humectant comprises at least one of panthenol, 1, 3-butanediol, glycerol, 1, 3-propanediol, betaine, dipropylene glycol, glyceryl polyether-26, erythritol, methyl propylene glycol, hydroxyethyl urea, sodium polyglutamate, levan and trehalose.
Further, the antioxidant composition further comprises a stabilizer, wherein the stabilizer comprises EDTA-disodium.
Further, the antioxidant composition further comprises a thickener comprising at least one of sclerotium rolfsii, xanthan gum, carbomer, gellan gum, xanthan gum, and hydroxyethyl cellulose.
Further, the antioxidant composition further comprises a preservative, wherein the preservative comprises at least one of chlorphenesin, methyl ester, phenoxyethanol, methylparaben, propylparaben, chlorphenesin, ethylhexylglycerin, hexamidine dihydrochloride and benzyl alcohol.
Further, the antioxidant composition also comprises a soothing agent, and the soothing agent is allantoin.
Further, the antioxidant composition also comprises a penetration enhancer, and the penetration enhancer is isosorbide dimethyl ether.
The second purpose of the invention is to provide a preparation method of the antioxidant composition, which comprises the following specific preparation steps:
weighing 0.5-2 parts of a tamarix chinensis flower extract or a tamarix chinensis leaf extract, 2-4 parts of a purslane extract and 3-9 parts of 1, 3-butanediol according to parts by weight;
adding the weighed extract of the Chinese tamarisk flowers or the extract of the Chinese tamarisk leaves and the extract of the purslane into 1, 3-butanediol, and mixing at the temperature of below 45 ℃ to obtain the antioxidant composition.
The third purpose of the invention is to provide the application of the antioxidant composition in skin care products, wherein the skin care products comprise water-type skin care products, gel-type skin care products, emulsion-type skin care products or cream-type skin care products.
The invention has the beneficial effects that:
the invention provides an antioxidant composition, which comprises the following components in parts by weight: 0.5-2 parts of tamarix chinensis flower extract; or 0.5-2 parts of tamarix chinensis leaf extract; and 2-4 parts of purslane extract. The invention inhibits the activity of free radical producing active enzyme through the extract of the Chinese tamarisk flowers or the extract of the Chinese tamarisk leaves, thereby inhibiting the generation of free radicals and inhibiting lipid oxidation. Preventing the reaction of the free radical with intracellular carbohydrate, protein, lipid and other matter to damage human body's cell and promote cell senility. The purslane extract has the effects of resisting allergy, inflammation and resisting various external irritations to skin, so that the antioxidant prepared by the invention has better antioxidant effect and more functions.
Detailed Description
The invention provides an antioxidant composition, a preparation method and application. In order that the invention may be more readily understood, reference will now be made to the following more particular description of the invention, examples of which are set forth below. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. These embodiments are provided so that this disclosure will be thorough and complete. The various starting materials used in the examples are, unless otherwise indicated, conventional commercial products.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
The numerical values set forth in the examples of the present invention are approximations, not necessarily values. All values within the error range may be included without limiting to the specific values disclosed in the embodiments of the present invention, where the error or experimental conditions allow.
The numerical ranges disclosed in the examples of the present invention are intended to indicate the relative amounts of the components in the mixture and the ranges of temperatures or other parameters recited in the other method examples.
The invention provides an antioxidant composition, which comprises the following components in parts by weight:
0.5-2 parts of tamarix chinensis flower extract; or
0.5-2 parts of tamarix chinensis leaf extract; and
2-4 parts of purslane extract.
Preferably, the antioxidant composition comprises the following components in parts by weight:
1.25 parts of tamarix chinensis flower extract; or
1.25 parts of tamarix chinensis leaf extract; and
2-4 parts of purslane extract.
In this example, tamarisk, (Latin's name: Tamarixchinensis Lour.), is called Salix verticillata, Salix chebula, Salix purpurea; tender branches and leaves of tamarix chinensis are traditional Chinese medicinal materials. Produced in various places in China. Fresh or dry. The tamarix chinensis branches are soft and attractive, and are in a buckeye posture, and flowers like red knotweed. Is often planted as garden ornamental planting. Can be used for treating pox, herpes, invagination, common cold, cough, and rheumatalgia. The extract of flos Tamaricis/folium Tamaricis contains quercetin, isorhamnetin, gallic acid, beta-sterol, daucosterol, stearic acid, etc.
The tamarix chinensis flower/leaf extract is prepared by the following method: cleaning and airing the branches and leaves of the tamarix chinensis with water; cutting the dried branches and leaves of the tamarix chinensis, taking out the branches, and sorting out broken branches and sundries; putting the sorted tamarix chinensis leaves into an oven, and drying for 50-60 minutes at 70-75 ℃; soaking the dried tamarix chinensis leaves in a softening solution for 25-30 minutes at the temperature of 30-35 ℃ for softening; washing the softened tamarix chinensis leaves with water, then putting the washed leaves into an oven, and drying the leaves for 15 to 20 minutes at the temperature of between 35 and 40 ℃; crushing the dried tamarix chinensis leaves in a crusher, and then sieving the crushed tamarix chinensis leaves through a 100-mesh and 120-mesh sieve to obtain tamarix chinensis leaf powder; mixing the tamarix chinensis leaf powder with an extraction solvent, adding the mixture into an extraction tank, and soaking for 20-24 hours; heating the extraction solvent by an electric heating sleeve until the temperature reaches 250-275 ℃ and the temperature is kept constant at 120-130 ℃ for 2-3 hours after the solvent is boiled by big fire; cooling the extraction solvent at constant temperature to 70-80 deg.C, filtering to obtain extractive solution, and concentrating at constant temperature to obtain Tamarix chinensis flower/leaf extract.
The isorhamnetin contained in the extract of the flowers/leaves of the tamarix chinensis is a quercetin flavonoid compound, which inhibits the generation of free radicals by inhibiting the activity of free radical-producing active enzymes and has certain complexing effect on metal ions, and can inhibit the reaction of the free radicals and an intermediate product generated by lipid chain oxidation, namely a lipid free radical or a lipid oxidation free radical, so as to terminate the chain reaction and inhibit the lipid oxidation. Preventing the reaction of the free radical with intracellular carbohydrate, protein, lipid and other matter to damage human body's cell and promote cell senility.
The flavonoid compound has strong direct scavenging effect on free radicals generated by organisms, can activate the inherent antioxidant system in the bodies to play an antioxidant role, simultaneously improves the activity of antioxidant enzymes of the organisms, indirectly enhances the scavenging effect on the oxidative free radicals, and thereby resists oxidative damage.
The herba Portulacae extract contains abundant amino acids, carotene, vitamin A, vitamin B, vitamin C, saccharide, protein, ferrum, phosphorus, etc. The purslane extract is mainly used for resisting allergy, inflammation and resisting various external irritations to the skin. The amino acids have contraction effect on vascular smooth muscle, central and peripheral property, and can relieve skin and inhibit skin pruritus caused by dryness, prevent skin dryness and aging, improve skin quality, and scavenge oxygen free radicals. Vitamin C is a strong antioxidant and is effective in resisting skin aging.
In a further embodiment of the present invention, the antioxidant composition further comprises a humectant comprising at least one of panthenol, 1, 3-butylene glycol, glycerin, 1, 3-propylene glycol, betaine, dipropylene glycol, glyceryl polyether-26, erythritol, methyl propylene glycol, hydroxyethyl urea, sodium polyglutamate, levan, trehalose.
In a further embodiment of the present invention, the antioxidant composition further comprises a stabilizer comprising EDTA-disodium. EDTA-disodium plays three roles in cosmetics:
1. can soften hard water.
2. The oxidation of the metal ions on the whole system is reduced.
3. Can adjust the pH value of the cosmetic, namely can automatically adjust the pH value of the cosmetic within a range suitable for a user so as to protect the skin from strong stimulation.
In a further embodiment of the present invention, the antioxidant composition further comprises a thickening agent comprising at least one of sclerotium rolfsii gum, xanthan gum, carbomer, gellan gum, xanthan gum, and hydroxyethyl cellulose.
In a further embodiment of the present invention, the antioxidant composition further comprises a preservative comprising at least one of chlorphenesin, methyl ester, phenoxyethanol, methylparaben, propylparaben, chlorphenesin, ethylhexylglycerin, hexamidine dihydrochloride, benzyl alcohol.
In a further embodiment of the present invention, the antioxidant composition further comprises a soothing agent, which is allantoin. Allantoin is an antioxidant, and is produced after the action of free radicals. Research shows that allantoin can directly act on keratin of skin, increase and promote hydration ability of stratum corneum, reduce water loss, moisten skin to make skin smooth, moist and pliable, and relieve and treat xerosis cutis. Meanwhile, allantoin also has the physiological functions of promoting cell growth, accelerating wound healing and softening keratin, so that the allantoin can also be used for treating chronic diseases such as ulcer and the like. Just because allantoin has the above effects, allantoin as an amphipathic compound has certain effects on human skin, and certain benefits can be obtained by reasonable use.
In a further embodiment of the present invention, the antioxidant composition further comprises a penetration enhancer, wherein the penetration enhancer is dimethyl isosorbide anhydride. The penetration enhancer can help the skin of the human body to absorb the antioxidant composition.
In a further embodiment of the present invention, the antioxidant composition further comprises a solvent comprising at least one of methyl propylene glycol and water. Convenient material obtaining and low cost. And the addition amount of the solvent is the balance of the total addition amount in percentage by mass of the antioxidant composition.
The invention also provides a preparation method of the antioxidant composition, which comprises the following specific steps:
weighing 0.5-2 parts of a tamarix chinensis flower extract or a tamarix chinensis leaf extract, 2-4 parts of a purslane extract and 3-9 parts of 1, 3-butanediol according to parts by weight;
adding the weighed extract of the Chinese tamarisk flowers or the extract of the Chinese tamarisk leaves and the extract of the purslane into 1, 3-butanediol, and mixing at the temperature of below 45 ℃ to obtain the antioxidant composition.
Further, the method comprises the step of prefabricating:
mixing adjuvants (panthenol, EDTA-disodium, Sclerotinia sclerotiorum, chlorphenesin, methyl ester, methyl propylene glycol, allantoin, and water), stirring to obtain adjuvant mixture, cooling to below 45 deg.C, adding flos Tamaricis/folium Tamaricis extract and herba Portulacae extract, and mixing to obtain antioxidant composition.
Further, in the prefabricating step, the auxiliary agent components are uniformly mixed, the temperature is increased to 80-85 ℃, and the mixture is stirred and kept for 20 min.
The antioxidant composition is obtained by reasonably matching the extract of the Chinese tamarisk flowers or the extract of the Chinese tamarisk leaves with the extract of the purslane according to a specific proportion, and is applied to cosmetics. The activity of enzyme producing free radicals is inhibited by the extract of the Chinese tamarisk flowers or the extract of the Chinese tamarisk leaves, and the extract has certain complexation effect on metal ions, so that the generation of free radicals is inhibited, the reaction of the free radicals and an intermediate product generated by lipid chain oxidation, namely a lipid free radical or a lipid oxidation free radical, can be inhibited, the chain reaction is stopped, and the lipid oxidation is inhibited. Preventing the reaction of the free radical with intracellular carbohydrate, protein, lipid and other matter to damage human body's cell and promote cell senility.
The flavonoid compound has strong direct scavenging effect on free radicals generated by organisms, can activate the inherent antioxidant system in the bodies to play an antioxidant role, simultaneously improves the activity of antioxidant enzymes of the organisms, indirectly enhances the scavenging effect on the oxidative free radicals, and thereby resists oxidative damage.
The herba Portulacae extract contains abundant amino acids, carotene, vitamin A, vitamin B, vitamin C, saccharide, protein, ferrum, phosphorus, etc. The purslane extract is mainly used for resisting allergy, inflammation and resisting various external irritations to the skin. The amino acids have contraction effect on vascular smooth muscle, central and peripheral property, and can relieve skin and inhibit skin pruritus caused by dryness, prevent skin dryness and aging, improve skin quality, and scavenge oxygen free radicals. Vitamin C is a strong antioxidant and is effective in resisting skin aging. The antioxidant composition can be applied to various cosmetic product forms, and has the characteristics of simple preparation method, wide application and capability of meeting market demands.
In another aspect, the invention provides the use of an antioxidant composition in a skin care product, including an aqueous skin care product, a gel skin care product, an emulsion skin care product, or a cream skin care product.
DETAILED DESCRIPTION OF EMBODIMENT (S) OF INVENTION
Embodiments of the present invention will be described in detail below with reference to examples 1 to 3 and comparative examples 1 to 3, but those skilled in the art will appreciate that the following examples are only illustrative of the present invention and should not be construed as limiting the scope of the present invention. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products commercially available.
The antioxidant compositions of examples 1-3 and comparative examples 1-3 were prepared according to the contents of the components in table 1 below in parts by weight.
TABLE 1
Examples 1-3 and comparative examples 1-3:
examples 1-3 and comparative examples 1-3 were set up with the ingredients and parts by weight used as shown in table 2:
TABLE 2 ingredients and ratios of antioxidant compositions of examples 1-3 and comparative examples 1-3
The preparation methods of the examples and comparative examples are the same as those of the specific embodiment.
Detection example 1:
the antioxidant compositions prepared in examples 1 to 3 were subjected to physicochemical index tests in accordance with QB/T2660-2004. The results are as follows:
(1) appearance: colorless or pale yellow liquid.
(2) Color: colorless or yellowish.
(3) Odor: a slight characteristic odor.
(4) pH value: 4.0-8.5.
(5) And (3) inspecting the heat resistance stability, keeping the temperature at (40 +/-1) DEG C for 24h, and ensuring that no obvious character difference exists between the temperature after the temperature is restored to the room temperature and before the test, so that the product is qualified.
(6) And cold resistance stability inspection, namely keeping the temperature of minus 8 +/-2 ℃ for 24h, and ensuring that no obvious character difference exists between the temperature recovered to room temperature and the temperature before the test, so that the product is qualified.
In conclusion, the stability test is passed in the range of the raw material dosage of the formula design, and the raw material meets the relevant national standard.
Detection example 2:
1) and (3) product safety test:
the skin care compositions obtained in examples and comparative examples were subjected to a human patch test according to the method described in technical specification for cosmetic safety (2015 edition).
The experimental population is as follows: total 36, 25 women, 11 men, age 21-59, 6 per group, composite subject volunteer enrollment criteria;
the test method comprises the following steps: the selection area is not more than 50mm2A suitable patch tester with a depth of about 1mm, wherein about 0.020-0.025mL of the test substance is added into the patch tester by a closed patch test method; the plaque test device is pasted on the curved side of the forearm of a subject, the subject is removed after 24h, the skin reaction is observed after 0.5h, 24h and 48h respectively after the removal, and the result is recorded according to the skin reaction grading standard in technical Specification for cosmetic safety (2015 edition).
And (3) test results: the 36 subjects scored 0 at 3 observation time points 0.5h, 24h, 48h after removal of the patch (negative response).
2) And (3) product efficacy test:
and (3) carrying out efficacy tests on the prepared antioxidant essence, including skin texture tests and skin wrinkle resistance tests, wherein the specific scheme is as follows:
skin texture test
(1) Taking the antioxidant essence of examples 1-3 and comparative examples 1-3.
(2) The left and right cheekbones of the face, the left and right cheeks at the intersection of the nose tip and the pupil, and the left and right sides at the intersection of the temple and the mouth corner of the subject were selected as the test areas.
(3) Skin texture was first determined by a technician using a Skin image analysis system (Skin visualizer SV600) at the experimental site prior to application of the example and comparative cosmetics five times per spot and averaged.
(4) Subjects after four weeks of continuous use of the example or comparative example cosmetics, Skin texture was tested using the Skin image analysis system (Skin visualizer SV 600).
(5) The number of each measurement at the test site of the subject was counted, and the change law of the skin texture was analyzed, thereby determining the efficacy of the example and comparative example cosmetics for the improvement of the skin texture. (Each subject was measured by the same technician each time.)
3) Anti-wrinkle experiment on human skin
The anti-wrinkle test of human skin is the most direct method for testing the anti-wrinkle effect.
The changes in the elasticity values of the applied areas were measured by a test population using the example and comparative cosmetics and then using a skin elasticity tester (current meter dual MPA580) under the direction of the skilled person. (Each subject was measured by the same technician each time.)
(1) Take the example and comparative example cosmetics.
(2) The left and right cheekbones of the face, the left and right cheeks at the intersection of the nose tip and the pupil, and the left and right sides at the intersection of the temple and the mouth corner of the subject were selected as the test areas.
(3) The gel is applied twice a day in the morning and at night, and the photo before application is used as a control. During the experiment, the subject was unable to apply any other cosmetic.
(4) After the subjects continued to use the example and comparative example cosmetics for four weeks, the skin elasticity values before and after use were counted.
(5) And counting the values measured at each time of the experimental part of the subject, and analyzing the skin elasticity change rule of the subject to evaluate the skin elasticity change condition of the subject.
The test population: 140 wrinkled persons with average age 35-45 years old. Wherein, 57 men and 83 women have healthy and undamaged skin. Each example and comparative example had 20 subjects.
After four weeks (28 days) of use of the product, the data are shown in tables 3 and 4.
TABLE 3
TABLE 4
According to the test data, comparative example 3, which did not contain one or more of the antioxidant compositions, was tested only under the base formula, with no significant change in the effect on the skin. In contrast, when the antioxidant compositions were added to examples 1 to 3, the effects of examples 1 to 3 on the skin were significant as shown in tables 3 and 4. The antioxidant composition contained in example 1 has a low content, but has an obvious effect on the skin, but the effect is obvious compared with that of comparative example 3 without the antioxidant composition, which shows that the added antioxidant composition has a good antioxidant effect. In comparative examples 1 and 2, the tamarix chinensis flower/leaf extract and the purslane extract are respectively and independently added, and in the case of the same basic formula, the comparative examples 1 and 2 are compared with the example 2 (added with the antioxidant composition), obviously, the effect of the antioxidant composition added in the example 2 after being used for 4 weeks is obviously better than that of the antioxidant composition added in the example 2 after being used for 4 weeks, and the synergistic effect of the antioxidant composition and the purslane extract is proved to be obvious. In conclusion, the antioxidant composition has an antioxidant effect.
The above description is only a preferred embodiment of the present invention, and not intended to limit the scope of the present invention, and all modifications and equivalents of the present invention, which are made by the present specification and directly/indirectly applied to other related technical fields within the spirit of the present invention are included in the scope of the present invention.
The above description of the embodiments is only intended to facilitate the understanding of the method of the invention and its core idea. It should be noted that, for those skilled in the art, it is possible to make various improvements and modifications to the present invention without departing from the principle of the present invention, and those improvements and modifications also fall within the scope of the claims of the present invention.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (10)
1. An antioxidant composition is characterized by comprising the following components in parts by weight:
0.5-2 parts of tamarix chinensis flower extract; or
0.5-2 parts of tamarix chinensis leaf extract; and
2-4 parts of purslane extract.
2. The antioxidant composition of claim 1, comprising in parts by weight:
1.25 parts of tamarix chinensis flower extract; or
1.25 parts of tamarix chinensis leaf extract; and
2-4 parts of purslane extract.
3. The antioxidant composition of claim 1, further comprising a humectant comprising at least one of panthenol, 1, 3-butylene glycol, glycerin, 1, 3-propylene glycol, betaine, dipropylene glycol, glyceryl polyether-26, erythritol, methyl propylene glycol, hydroxyethyl urea, sodium polyglutamate, levan, trehalose.
4. The antioxidant composition of claim 1, further comprising a stabilizer comprising EDTA-disodium.
5. The antioxidant composition of claim 1, further comprising a thickener comprising at least one of sclerotium rolfsii, xanthan gum, carbomer, gellan gum, xanthan gum, and hydroxyethyl cellulose.
6. The antioxidant composition of claim 1, further comprising a preservative comprising at least one of chlorphenesin, methyl ester, phenoxyethanol, methylparaben, propylparaben, chlorphenesin, ethylhexylglycerin, hexamidine dihydrochloride, benzyl alcohol.
7. The antioxidant composition of claim 1, further comprising a soothing agent, the soothing agent being allantoin.
8. The antioxidant composition of claim 1, further comprising a penetration enhancer, the penetration enhancer being dimethyl isosorbide anhydride.
9. A process for the preparation of an antioxidant composition as claimed in any one of claims 1 to 8, characterized by the specific preparation steps of:
weighing 0.5-2 parts of a tamarix chinensis flower extract or a tamarix chinensis leaf extract, 2-4 parts of a purslane extract and 3-9 parts of 1, 3-butanediol according to parts by weight;
adding the weighed extract of the Chinese tamarisk flowers or the extract of the Chinese tamarisk leaves and the extract of the purslane into 1, 3-butanediol, and mixing at the temperature of below 45 ℃ to obtain the antioxidant composition.
10. Use of the antioxidant composition of any of claims 1-8 in skin care products, including aqueous, gel, emulsion or cream type skin care products.
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