CN110585079A - Radiation-resistant composition containing food-borne peptide and radiation-resistant emulsion thereof - Google Patents

Radiation-resistant composition containing food-borne peptide and radiation-resistant emulsion thereof Download PDF

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CN110585079A
CN110585079A CN201910849639.XA CN201910849639A CN110585079A CN 110585079 A CN110585079 A CN 110585079A CN 201910849639 A CN201910849639 A CN 201910849639A CN 110585079 A CN110585079 A CN 110585079A
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weight
radiation
parts
resistant
peptide
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王胜地
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Daddy's Choice Inc
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Daddy's Choice Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/645Proteins of vegetable origin; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9755Gymnosperms [Coniferophyta]
    • A61K8/9767Pinaceae [Pine family], e.g. pine or cedar
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations

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  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Cosmetics (AREA)

Abstract

The embodiment of the invention discloses a radiation-resistant composition containing food-borne peptide and radiation-resistant emulsion thereof, belonging to the technical field of cosmetics. The anti-radiation composition comprises, by weight, 2-4 parts of deep sea fish collagen peptide, 1-2 parts of soybean polypeptide, 0.5-1.5 parts of rice protein peptide, 0.2-0.5 part of fructo-oligosaccharide, 0.5-1 part of agaricus blazei polysaccharide, 0.5-1 part of green tea extract, 0.5-1 part of emblic leafflower fruit extract and 0.5-1 part of pine bark extract. The anti-radiation composition provided by the embodiment of the invention can effectively remove free radicals, so that the damage of the free radicals to a human body is reduced, and the functions of repairing skin and delaying aging are achieved. The anti-radiation emulsion disclosed by the embodiment of the invention has multiple effects of moisturizing, resisting radiation and resisting oxidation, deeply activates collagen regeneration, repairs and resists oxidation, improves the moisture content of skin, moisturizes and moisturizes, and plays a role in nourishing and protecting, so that the skin problem is improved.

Description

Radiation-resistant composition containing food-borne peptide and radiation-resistant emulsion thereof
Technical Field
The embodiment of the invention relates to the technical field of cosmetics, and particularly relates to a radiation-resistant composition containing food-borne peptide and radiation-resistant emulsion thereof.
Background
Skin aging is a complex biological phenomenon, and is mainly influenced by genetic factors and environmental factors, wherein the genetic factors refer to endogenous factors and mainly refer to an inevitable aging process caused by the increase of age; environmental factors refer to exogenous factors such as our dietary habits and lifestyle.
Scientific research shows that life is an oxidation process, which causes the aging of human body and the radical of disease (active oxygen free radical), and becomes the root cause of disease by generating oxidative damage, which affects health and longevity.
The living environment of modern people is full of various environmental pollutions such as radiation, air, water, noise and the like, and in addition, the tense living pace, the working pressure and the bad living habits can greatly increase free radicals, and unstable free radicals continuously attack healthy skin tissues in vivo to generate a series of injury reactions, so that the skin has the symptoms of accelerated aging such as darkness, looseness, fine wrinkles and the like. Therefore, it is necessary to remove excessive free radicals in time so that the generation and removal of free radicals in the human body are in dynamic balance.
In recent years, small molecular peptides are used in skin care products, have anti-wrinkle effects and are mainly applied to essence components such as pentapeptide-3, palmitoyl pentapeptide-3 and the like. The addition of deoxyribonucleic acid, natural protein and the like to cosmetics in the last century has become a popular trend, but these macromolecules are difficult to be absorbed through the skin. The peptide is a structural fragment for forming protein, has the advantages of small molecular weight and easy absorption, and can play a unique physiological role at the same time. China is a large country for grain export, and crops such as soybean and rice are more. Therefore, the food-source peptide is expected to be widely applied to cosmetics.
The emulsion is a liquid cream cosmetic, has good skin moistening effect, can supplement moisture of skin, isolate external dry climate, prevent excessive skin moisture loss, and avoid problems of skin dryness, water shortage, sensitivity and the like. At present, basic moisturizing components are mostly added into cosmetic emulsion, moisturizing is the main purpose, the emulsion serving as a basic skin care product needs to have other effects so as to meet the modern fast-paced life, and food peptide is added into the emulsion, so that the safety of the cosmetic emulsion is improved while resources are reasonably utilized.
Disclosure of Invention
Therefore, the embodiment of the invention provides a radiation-resistant composition containing food-borne peptides and a radiation-resistant emulsion thereof, wherein the radiation-resistant composition can effectively remove free radicals, so that the damage of the free radicals to a human body is reduced, and the functions of repairing skin and delaying senility are achieved. The anti-radiation emulsion has multiple effects of moisturizing, resisting radiation and resisting oxidation, deeply activates collagen regeneration, repairs and resists oxidation, improves the moisture content of skin, moisturizes and moisturizes, and plays a role in nourishing and protecting, thereby improving the skin problem.
In order to achieve the above object, the embodiments of the present invention provide the following technical solutions:
according to a first aspect of the embodiments of the present invention, there is provided a food-derived peptide-containing radiation-resistant composition comprising, by weight, 2 to 4 parts of a deep sea fish collagen peptide, 1 to 2 parts of a soybean polypeptide, 0.5 to 1.5 parts of a rice protein peptide, 0.2 to 0.5 part of fructooligosaccharide, 0.5 to 1 part of agaricus blazei murill polysaccharide, 0.5 to 1 part of a green tea extract, 0.5 to 1 part of an emblic leafflower extract, and 0.5 to 1 part of a pine bark extract.
Further, the anti-radiation composition comprises 3 parts of deep sea fish collagen peptide, 1.5 parts of soybean polypeptide, 1 part of rice protein peptide, 0.3 part of fructooligosaccharide, 0.8 part of agaricus blazei polysaccharide, 0.8 part of green tea extract, 0.8 part of emblic leafflower fruit extract and 0.8 part of pine bark extract in parts by weight.
According to a second aspect of the embodiments of the present invention, there is provided a radiation-resistant emulsion, including the following raw materials by weight: 5.7-12% of the anti-radiation composition, 8.1-13.35% of a humectant, 0.15-0.6% of a thickening agent, 3-13% of an emollient, 2-9% of an emulsifier, 0.05-0.1% of a chelating agent and 0.5-1% of a preservative.
Further, the humectant comprises 3-5 parts by weight of glycerin, 5-8 parts by weight of isoprene glycol, 0.05-0.2 part by weight of sodium hyaluronate and 0.05-0.15 part by weight of sodium pyrrolidone carboxylate.
Further, the thickening agent comprises 0.05-0.1 part by weight of carbomer and 0.1-0.5 part by weight of acrylic acid (ester)/C10-C30 alkanol acrylate cross-linked polymer.
Further, the skin moisturizer comprises 1-5 parts by weight of ostrich oil and 2-8 parts by weight of chinaroot flower seed oil.
Further, the emulsifier comprises 0.5-1 part by weight of polyglycerol-3 methyl glucose distearate, 0.5-5 parts by weight of pentaerythritol tetracaprylate and 1-3 parts by weight of 16/18 alcohol.
Further, the chelating agent is EDTA-2Na, and the preservative is PE 9010.
According to a third aspect of embodiments of the present invention, there is provided a method of preparing a radiation resistant emulsion, the method comprising the steps of:
1) keeping the equipment clean;
2) under the condition of stirring, sequentially adding glycerol, isoprene glycol, sodium hyaluronate, sodium pyrrolidone carboxylate and carbomer into a water phase pot, heating to 75-80 ℃, stirring until the raw materials are uniformly dissolved, then adding deionized water, and continuing stirring and keeping the temperature for 40-50 min;
3) under the condition of stirring, sequentially adding acrylic acid (ester)/C10-C30 alkanol acrylate cross-linked polymer, ostrich oil, white chinlon oil, polyglycerol-3 methyl glucose distearate, pentaerythritol tetracaprylate and 16/18 alcohol into an oil phase pot, heating to 75-80 ℃, and stirring until the raw materials are uniformly dissolved;
4) slowly adding the materials in the water phase pot into the oil phase pot under the homogenization condition;
5) and (3) stirring and cooling the homogenized materials to 40-45 ℃, adding deep sea fish collagen peptide, soybean polypeptide, rice protein peptide, fructo-oligosaccharide, agaricus blazei polysaccharide, green tea extract, emblic leafflower fruit extract, pine bark extract and chelating agent, stirring uniformly, adding preservative, stirring and cooling to room temperature, and discharging.
Further, the weight percentage of each substance is as follows: the weight percentage of each substance is as follows: 2-4% of deep sea fish collagen peptide, 1-2% of soybean polypeptide, 0.5-1.5% of rice protein peptide, 0.2-0.5% of fructo-oligosaccharide, 0.5-1% of agaricus blazei polysaccharide, 0.5-1% of green tea extract, 0.5-1% of emblic leafflower fruit extract, 0.5-1% of pine bark extract, 3-5% of glycerol, 5-8% of isoprene glycol, 0.05-0.2% of sodium hyaluronate, 0.05-0.15% of sodium pyrrolidone carboxylate, 0.05-0.1% of carbomer, 0.1-0.5% of acrylic acid (ester)/C10-C30 alkanol acrylate cross-linked polymer, 1-5% of ostrich oil, 2-8% of white pond flower seed oil, 0.5-1% of polyglycerol-3 methyl glucose distearate, 0.5-5% of pentaerythritol tetracaprylate, 1-3% of 16/18 alcohol, 0.05-0.1% of EDTA-2 Na0.1% of PE 90100.5-1% and the balance of.
The invention relates to the main raw materials with the following functions:
deep sea fish collagen peptide: the deep sea cod skin is used as a main raw material, and the small molecular peptide is refined by a biological enzymolysis process, can promote the formation of bones, and enhances a bone collagen structure under a low calcium level, so that the bone strength is improved, and the deep sea cod skin has the effects of preventing osteoporosis, protecting gastric mucosa, resisting ulcer and allergy, inhibiting blood pressure increase, preventing cancer and the like.
Soybean polypeptide: the protein hydrolysate is obtained by performing special treatment on soybean protein after protease action, is rich in 22 amino acids, 9 of which are essential amino acids which cannot be synthesized by human body, has the capability of enhancing the resistance of human body, relieving fatigue and enhancing muscle, and can promote metabolism. The soybean peptide has strong oxidation resistance and can repair damaged cells. Therefore, the soybean protein peptide is very considerable as a raw material in cosmetics and has strong market development potential.
Rice protein peptide: the amino acid polymer connected by peptide bonds is obtained by taking rice protein as a raw material and carrying out enzymolysis, fermentation and other steps. Is mainly applied to health food and fermentation industry, and can promote basal metabolism. The rice protein peptide not only can keep the original nutritive value of the rice protein, but also can enrich the functional activity of the rice protein, and researches show that the rice protein peptide has the functional activity of reducing blood pressure, blood fat and cholesterol, resisting bacteria and resisting oxidation.
Fructo-oligosaccharide: the fructo-oligosaccharide added into the cosmetic can promote the growth of skin probiotics, help to maintain skin barrier, maintain flora balance, enhance skin resistance, inhibit the growth of harmful bacteria on the surface of facial skin, effectively slow down pigmentation, fade and eliminate color spots, and has good effect on skin health care.
Agaricus blazei polysaccharide: the Agaricus blazei Murill polysaccharide is effective active ingredient extracted from high-quality Agaricus blazei Murill fruiting body, and has effects of improving immunity, resisting tumor, resisting oxidation, reducing blood sugar, reducing cholesterol, and resisting inflammation. The agaricus blazei polysaccharide also has the effect of repairing cells, can quickly supplement polysaccharide lacking in intercellular substance, ensures the timely repair of cell membranes, ensures the health of human skin tissues, can also obviously improve the toughness and the sealing property of the cell membranes and improve the immunity of the cells, which is not possessed by common fungus polysaccharide.
Green tea extract: the green tea extract is a main extraction component of common green tea in China, is rich in nutrients such as tea polyphenol, catechin, caffeine, amino acid, vitamins and the like. Has good antioxidation effect due to more hydroxyl groups.
Emblic leafflower fruit extract: the emblic leafflower fruit extract contains more polyphenol flavonoid components, and has the effects of resisting aging, resisting oxidation and converging through strong free radical scavenging action.
Pine bark extract: the pine bark extract is rich in procyanidine, has strong oxidation resistance and special chemical and physiological activities, has multiple functions in skin care, and has the effects of resisting wrinkles and whitening, and the anti-wrinkle effect of procyanidine can maintain the synthesis of collagen; inhibition of elastase; help the body to protect collagen and improve the elasticity of the skin; improving the healthy circulation of the skin. Thereby avoiding or reducing the occurrence of wrinkles. Can inhibit enzymes damaging skin health, maintain skin intact, prevent skin wrinkle, skin laxity and related skin aging, and has effects of recovering or enhancing immunity function of skin, repairing epidermal cell and blood vessel, and protecting skin health circulation.
The INCI name/english name of each raw material used in the embodiment of the present invention is as follows:
the embodiment of the invention has the following advantages:
the radiation-resistant composition containing the food-borne peptide is prepared by compounding deep-sea fish collagen peptide, soybean polypeptide, rice protein peptide, fructo-oligosaccharide, agaricus blazei polysaccharide, green tea extract, emblic leafflower fruit extract and pine bark extract according to a certain proportion, wherein the soybean polypeptide and the rice protein peptide have strong permeability to skin, can quickly activate epidermal cells, supplement nutrition to skin, simultaneously stimulate dermal fibroblasts, accelerate the synthesis of collagen protein, have good skin-care effect and can keep the elasticity of the skin; the soybean polypeptide, the rice protein peptide, the agaricus blazei polysaccharide, the green tea extract, the emblic leafflower fruit extract and the pine bark extract are compounded to have better antioxidant effect; the fructo-oligosaccharide can regulate the microecological balance of skin, maintain the healthy skin barrier on the surface of the skin, and effectively remove free radicals by combining the substances, thereby reducing the damage of the free radicals to the human body, and achieving the functions of repairing the skin and delaying senility.
The ostrich oil and the white pool flower seed oil contained in the skin moisturizer are mild and stable, a complete protective film is formed on the surface of the skin, and external injuries are isolated while water is kept.
The invention combines the current market demand, reasonably utilizes the grain resources of China, applies the micromolecule food peptide to the production of cosmetics, is safe and reliable, is beneficial to the absorption of skin, and has the characteristics of naturalness, mildness, no residue, no irritation and stable performance. Meanwhile, the preparation method of the anti-radiation emulsion is simple to operate, is easy for factory amplification production, and has extremely strong market development potential.
Detailed Description
The present invention is described in terms of particular embodiments, other advantages and features of the invention will become apparent to those skilled in the art from the following disclosure, and it is to be understood that the described embodiments are merely exemplary of the invention and that it is not intended to limit the invention to the particular embodiments disclosed. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
The radiation-resistant composition containing food-derived peptides of this example includes, by weight, 3.5 parts of deep-sea fish collagen peptide, 2 parts of soybean polypeptide, 0.5 part of rice protein peptide, 0.2 part of fructooligosaccharide, 0.7 part of agaricus blazei polysaccharide, 1 part of green tea extract, 0.5 part of emblic leafflower fruit extract, and 0.5 part of pine bark extract.
Example 2
The food-derived peptide-containing radiation-resistant composition of the present example includes, by weight, 3 parts of deep sea fish collagen peptide, 1.5 parts of soybean polypeptide, 1 part of rice protein peptide, 0.3 part of fructooligosaccharide, 0.8 part of agaricus blazei polysaccharide, 0.8 part of green tea extract, 0.8 part of emblic leafflower fruit extract, and 0.8 part of pine bark extract.
Example 3
The food-derived peptide-containing anti-radiation composition of the present example includes, by weight, 4 parts of deep sea fish collagen peptide, 1 part of soybean polypeptide, 1.5 parts of rice protein peptide, 0.4 part of fructooligosaccharide, 1 part of agaricus blazei polysaccharide, 0.8 part of green tea extract, 1 part of emblic leafflower fruit extract, and 1 part of pine bark extract.
Example 4
The food-derived peptide-containing radiation-resistant composition of this example includes, by weight, 2 parts of deep sea fish collagen peptide, 1 part of soybean polypeptide, 1.2 parts of rice protein peptide, 0.5 part of fructooligosaccharide, 0.5 part of agaricus blazei polysaccharide, 0.5 part of green tea extract, 0.5 part of emblic leafflower fruit extract, and 1 part of pine bark extract.
Example 5
The radiation-resistant emulsion of the embodiment comprises the following raw materials: the radiation resistant composition of example 1, glycerin, isoprene glycol, sodium hyaluronate, sodium pyrrolidone carboxylate, carbomer, acrylic/C10-C30 alkanol acrylate crosspolymer, ostrich oil, meadowfoam seed oil, polyglyceryl-3 methyl glucose distearate, pentaerythritol tetracaprylate, 16/18 alcohol, EDTA-2Na, PE9010, and deionized water. The weight percentage of the raw materials is shown in table 1.
The preparation method comprises the following steps:
1) keeping the equipment clean;
2) under the condition of stirring, sequentially adding glycerol, isoprene glycol, sodium hyaluronate, sodium pyrrolidone carboxylate and carbomer into a water phase pot, heating to 75 ℃, stirring until the raw materials are uniformly dissolved, then adding deionized water, and continuing stirring and keeping the temperature for 45 min;
3) under the condition of stirring, sequentially adding acrylic acid (ester)/C10-C30 alkanol acrylate cross-linked polymer, ostrich oil, white chinlon oil, polyglycerol-3 methyl glucose distearate, pentaerythritol tetracaprylate and 16/18 alcohol into an oil phase pot, heating to 75 ℃, and stirring until the raw materials are uniformly dissolved;
4) slowly adding the materials in the water phase pot into the oil phase pot under the homogenization condition;
5) stirring and cooling the homogenized materials to 40 ℃, adding deep sea fish collagen peptide, soybean polypeptide, rice protein peptide, fructo-oligosaccharide, agaricus blazei polysaccharide, green tea extract, emblic leafflower fruit extract, pine bark extract and EDTA-2Na, stirring uniformly, adding PE9010, stirring and cooling to room temperature, and discharging.
Examples 6 to 8
The radiation-resistant emulsions of examples 6-8 respectively comprise the radiation-resistant compositions of examples 2-4, and the weight percentage ratio of the raw materials is shown in Table 1.
TABLE 1
Comparative example 1
The radiation-resistant composition of this comparative example differs from example 1 in that it does not contain a soybean polypeptide, and it includes 3.5 parts by weight of a deep-sea fish collagen peptide, 0.5 parts by weight of a rice protein peptide, 0.2 parts by weight of fructo-oligosaccharide, 0.7 parts by weight of agaricus blazei murrill polysaccharide, 1 part by weight of a green tea extract, 0.5 parts by weight of an emblic leafflower fruit extract, and 0.5 parts by weight of a pine bark extract.
Comparative example 2
The radiation-resistant composition of this comparative example is different from example 1 in that it includes 3.5 parts of deep sea fish collagen peptide, 2 parts of soybean polypeptide, 0.2 part of fructo-oligosaccharide, 0.7 part of agaricus blazei murill polysaccharide, 1 part of green tea extract, 0.5 part of emblic leafflower fruit extract, 0.5 part of pine bark extract in parts by weight, excluding the rice protein peptide.
Comparative example 3
The radiation resistant composition of this comparative example is different from example 1 in that it includes 3.5 parts by weight of deep sea fish collagen peptide, 2 parts by weight of soybean polypeptide, 0.5 part by weight of rice protein peptide, 0.2 part by weight of fructooligosaccharide, 1 part by weight of green tea extract, 0.5 part by weight of emblic leafflower fruit extract, 0.5 part by weight of pine bark extract, excluding agaricus blazei murill polysaccharide.
Comparative example 4
The radiation-resistant composition of this comparative example is different from that of example 1 in that the compounding ratio of the components is different, and the radiation-resistant composition of this comparative example comprises 3.5 parts by weight of deep sea fish collagen peptide, 0.5 part by weight of soybean polypeptide, 2 parts by weight of rice protein peptide, 0.2 part by weight of fructo-oligosaccharide, 0.7 part by weight of agaricus blazei murill polysaccharide, 1 part by weight of green tea extract, 0.5 part by weight of emblic leafflower fruit extract, and 0.5 part by weight of pine bark extract.
Comparative example 5
The radiation-resistant composition of this comparative example is different from that of example 1 in that the compounding ratio of the components is different, and the radiation-resistant composition of this comparative example comprises 3.5 parts by weight of deep sea fish collagen peptide, 2 parts by weight of soybean polypeptide, 0.5 part by weight of rice protein peptide, 0.2 part by weight of fructo-oligosaccharide, 0.7 part by weight of agaricus blazei murill polysaccharide, 1.5 parts by weight of green tea extract, 0.2 part by weight of emblic leafflower fruit extract, and 0.3 part by weight of pine bark extract.
Test example 1
In vitro antioxidant activity test by DPPH method
The test method comprises the following steps: through the pairing combination of 1 stable free radical in DPPH molecules and one electron provided by an antioxidant, the characteristic purple of DPPH disappears, and the antioxidant capacity of a sample to be tested is evaluated.
5mL of DPPH ethanol solution with the mass concentration of 0.025g/L is taken, 1mL of ethanol solution of a sample to be detected with the mass concentration of 0.05g/L is added, the absorbance at 517nm is tracked and determined, and the determination is carried out once every 1 min. The absorbance continues to decrease as DPPH radicals are scavenged. Until the absorbance remained constant. The clearance rate of the sample to be tested to DPPH free radicals is calculated according to the following formula:
(Ao-Ax)/Ao × 100%, wherein: ao is the initial absorbance value of the DPPH ethanol solution; ax is the constant absorbance value of the DPPH ethanol solution after the ethanol solution of the sample to be detected is added. The results of the DPPH radical scavenging test of the radiation resistant compositions of examples 1-4 and comparative examples 1-5 are shown in Table 2.
TABLE 2
Sample (I) DPPH radical clearance rate
Example 1 93.2%
Example 2 97.2%
Example 3 88.3%
Example 4 90.9%
Comparative example 1 70.1%
Comparative example 2 68.7%
Comparative example 3 75.6%
Comparative example 4 72.8%
Comparative example 5 70.5%
As can be seen from Table 2, the radiation-resistant compositions of examples 1 to 4 according to the present invention have a significantly higher DPPH radical scavenging ability than those of comparative examples 1 to 5. The radiation-resistant composition in example 2 has a better effect of removing DPPH free radicals, and the proportion relationship of the components is more reasonable.
Test example 2
Stability testing
According to the national standard GB/T29665-2013 and reference GB/T16497-2007, the radiation-resistant emulsion of the embodiment of the invention is subjected to a high and low temperature storage stability test.
After centrifuging for 30min at 3000r/min, observing whether the emulsion has layering, solid precipitation or other unstable phenomena; keeping at 40 + -1 deg.C for 24h, returning to room temperature, keeping for 8h, and observing whether the emulsion has layering, solid precipitation or other instability phenomena; keeping at (-10 + -1) deg.C for 24h, and then returning to room temperature and keeping for 8h to determine whether the emulsion has delamination, solid precipitation or other instability phenomena.
The radiation resistant emulsions of examples 5-8 of the present invention did not exhibit thinning, discoloration, delamination, and hardness change during the above tests. Therefore, the radiation-resistant emulsion of the embodiment of the invention has stable performance.
Test example 3
Safety test
The anti-radiation emulsion of the invention was subjected to a human body patch test with reference to GB 17149.1-1997 general rules of diagnosis of cosmetic skin diseases and treatment principles, and 20 test volunteers with normal physical conditions, no allergy history and no cosmetic allergy history were selected and randomly divided into 4 groups of 5 persons, and the anti-radiation emulsion prepared in examples 5-8 was used by each group of test volunteers.
The radiation resistant emulsion sample was placed in a plaque tester with the control well blank, i.e., without smearing any material. The radiation resistant emulsion sample and the blank control were applied to the forearm flexor of the test volunteer with a non-irritating tape and kept for 24 h. And (5) observing the skin reaction 30min after the spot removing tester is removed, and observing the skin reaction once again after 24h and 48h of the spot sticking test.
All the subjects have no adverse skin reaction 30min, 24h and 48h after the plaque tester is removed, which indicates that the anti-radiation emulsion of the embodiment of the invention has no irritation to human skin.
Test example 4
Human body efficacy test
120 test volunteers (30 men, 90 women, age 25-45 years) from different areas were selected, criteria for selection: the skin is in a normal state, the physical condition is normal, no allergy history exists, no cosmetic allergy history exists, and the skin faces a computer for at least 6 hours every day. All volunteers were randomly divided into trial 1-4 groups of 30 persons each, using the radiation resistant emulsions of examples 5-8, respectively, in the morning and evening of each day, at a dose of about 2 g.
The satisfaction of each group of volunteers on three aspects of skin glossiness, skin moisture and skin elasticity after 4 weeks of continuous use is evaluated. The results of the self-assessment of each group of test volunteers are shown in table 3.
TABLE 3
As can be seen from Table 3, after 4 weeks of using the anti-radiation emulsion of the embodiment of the invention, the facial skin of trial volunteers who use computers for a long time is ruddy and glossy, moist and elastic, and can obviously improve the adverse phenomena of dark, yellow and dry skin and the like.
The anti-radiation emulsion disclosed by the embodiment of the invention can effectively resist the external damage to the skin, activate the skin bottom, refresh the skin, maintain the skin to be young and healthy and not easy to age. Meanwhile, allergic symptoms such as skin allergy, red swelling and the like do not appear in the test process.
Although the invention has been described in detail above with reference to a general description and specific examples, it will be apparent to one skilled in the art that modifications or improvements may be made thereto based on the invention. Accordingly, such modifications and improvements are intended to be within the scope of the invention as claimed.

Claims (10)

1. The radiation-resistant composition containing food-borne peptides is characterized by comprising 2-4 parts by weight of deep-sea fish collagen peptide, 1-2 parts by weight of soybean polypeptide, 0.5-1.5 parts by weight of rice protein peptide, 0.2-0.5 part by weight of fructo-oligosaccharide, 0.5-1 part by weight of agaricus blazei murill polysaccharide, 0.5-1 part by weight of green tea extract, 0.5-1 part by weight of emblic leafflower fruit extract and 0.5-1 part by weight of pine bark extract.
2. The food-derived peptide-containing radiation-resistant composition according to claim 1, wherein the radiation-resistant composition comprises 3 parts by weight of a deep sea fish collagen peptide, 1.5 parts by weight of a soybean polypeptide, 1 part by weight of a rice protein peptide, 0.3 part by weight of fructo-oligosaccharide, 0.8 part by weight of agaricus blazei murrill polysaccharide, 0.8 part by weight of a green tea extract, 0.8 part by weight of an emblic leafflower fruit extract, and 0.8 part by weight of a pine bark extract.
3. The radiation-resistant emulsion is characterized by comprising the following raw materials in percentage by weight: 5.7-12% of the radiation-resistant composition as defined in claim 1 or 2, 8.1-13.35% of a humectant, 0.15-0.6% of a thickener, 3-13% of an emollient, 2-9% of an emulsifier, 0.05-0.1% of a chelating agent, and 0.5-1% of a preservative.
4. The radiation-resistant emulsion according to claim 3, wherein the humectant comprises 3 to 5 parts by weight of glycerin, 5 to 8 parts by weight of isoprene glycol, 0.05 to 0.2 part by weight of sodium hyaluronate, and 0.05 to 0.15 part by weight of sodium pyrrolidone carboxylate.
5. The radiation-resistant emulsion according to claim 3, wherein the thickener comprises 0.05 to 0.1 part by weight of carbomer and 0.1 to 0.5 part by weight of acrylic acid/C10-C30 alkanol acrylate crosspolymer.
6. The radiation-resistant emulsion according to claim 3, wherein the emollient comprises 1-5 parts by weight of ostrich oil and 2-8 parts by weight of meadowfoam seed oil.
7. The radiation-resistant emulsion according to claim 3, wherein the emulsifier comprises 0.5-1 part by weight of polyglyceryl-3-methylglucose distearate, 0.5-5 parts by weight of pentaerythritol tetracaprylate, and 1-3 parts by weight of 16/18 alcohol.
8. The radiation-resistant emulsion according to claim 3, wherein the chelating agent is EDTA-2Na and the preservative is PE 9010.
9. A method for preparing a radiation-resistant emulsion, comprising the steps of:
1) keeping the equipment clean;
2) under the condition of stirring, sequentially adding glycerol, isoprene glycol, sodium hyaluronate, sodium pyrrolidone carboxylate and carbomer into a water phase pot, heating to 75-80 ℃, stirring until the raw materials are uniformly dissolved, then adding deionized water, and continuing stirring and keeping the temperature for 40-50 min;
3) under the condition of stirring, sequentially adding acrylic acid (ester)/C10-C30 alkanol acrylate cross-linked polymer, ostrich oil, white chinlon oil, polyglycerol-3 methyl glucose distearate, pentaerythritol tetracaprylate and 16/18 alcohol into an oil phase pot, heating to 75-80 ℃, and stirring until the raw materials are uniformly dissolved;
4) slowly adding the materials in the water phase pot into the oil phase pot under the homogenization condition;
5) and (3) stirring and cooling the homogenized materials to 40-45 ℃, adding deep sea fish collagen peptide, soybean polypeptide, rice protein peptide, fructo-oligosaccharide, agaricus blazei polysaccharide, green tea extract, emblic leafflower fruit extract, pine bark extract and EDTA-2Na, stirring uniformly, adding PE9010, stirring and cooling to room temperature, and discharging.
10. The preparation method of the radiation-resistant emulsion according to claim 9, wherein the weight percentage of each substance is as follows: 2-4% of deep sea fish collagen peptide, 1-2% of soybean polypeptide, 0.5-1.5% of rice protein peptide, 0.2-0.5% of fructo-oligosaccharide, 0.5-1% of agaricus blazei polysaccharide, 0.5-1% of green tea extract, 0.5-1% of emblic leafflower fruit extract, 0.5-1% of pine bark extract, 3-5% of glycerol, 5-8% of isoprene glycol, 0.05-0.2% of sodium hyaluronate, 0.05-0.15% of sodium pyrrolidone carboxylate, 0.05-0.1% of carbomer, 0.1-0.5% of acrylic acid (ester)/C10-C30 alkanol acrylate cross-linked polymer, 1-5% of ostrich oil, 2-8% of white pond flower seed oil, 0.5-1% of polyglycerol-3 methyl glucose distearate, 0.5-5% of pentaerythritol tetracaprylate, 1-3% of 16/18 alcohol, 0.05-0.1% of EDTA-2Na, 25-1% of PE 90100.5, and the balance of deionized.
CN201910849639.XA 2019-09-09 2019-09-09 Radiation-resistant composition containing food-borne peptide and radiation-resistant emulsion thereof Pending CN110585079A (en)

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