CN110882183A

CN110882183A - Anti-radiation skin care product and preparation method thereof

Info

Publication number: CN110882183A
Application number: CN201911393858.8A
Authority: CN
Inventors: 杜立波
Original assignee: Linxi Beijing Biotechnology Co Ltd
Current assignee: Linxi Beijing Biotechnology Co Ltd
Priority date: 2019-12-30
Filing date: 2019-12-30
Publication date: 2020-03-17

Abstract

The invention discloses an anti-radiation skin care product and a preparation method thereof, wherein the skin care product comprises the following components: 16 to 20 percent of humectant, 0.01 to 0.2 percent of preservative, 0.2 to 1 percent of solubilizer, 0.1 to 0.5 percent of thickener, 1 to 3 percent of skin conditioner, 0.1 to 0.5 percent of chelating agent, 0.1 to 10 percent of antioxidant, 0.1 to 0.2 percent of aromatic, 0.1 to 2 percent of anti-allergic agent and the balance of water. The preparation method comprises the following steps: the raw materials are mixed according to a certain sequence to prepare the anti-radiation skin care product. The anti-radiation skin care product can protect the photodamage of the skin surface caused by radiation, and can enter deep organism circulation to protect the photodamage of deep skin; meanwhile, the skin care product has the functions of smoothing, tendering and resisting aging of skin, and has high safety and wide market prospect.

Description

Anti-radiation skin care product and preparation method thereof

Technical Field

The invention belongs to the field of skin care products, and relates to an anti-radiation skin care product and a preparation method thereof.

Background

The ultraviolet rays reach the ground more and more due to the destruction of the atmospheric ozone layer caused by the development of industrialization and the aggravation of environmental pollution, so that the influence of the ultraviolet rays on the skin of a human body is becoming one of the more and more concerned problems. Ultraviolet irradiation can induce the generation of active oxygen, activate related signal pathways in organisms, and further continuously degrade components such as collagen and elastic fibers in extracellular matrix, so that skin photoaging is caused. In addition, with the development of science and technology, electronic products, such as: the mobile phone, the computer, the television, the microwave oven and the like increase the life quality of people and also inevitably bring some potential radiation injuries. The radiation source can also be used in combination with other environmental factors (such as smoking, chemicals, etc.) to cause various skin diseases, such as sunburn, light eruption, skin tumor, etc. The method not only seriously affects the physical and psychological health of people, but also brings heavy economic burden to families and society. Therefore, how to prevent and repair the skin damage caused by light radiation not only becomes a hot problem of biological scientist's attention, but also becomes one of the problems to be solved in the field of skin care products.

At present, radiation-resistant skin care products are available in the field of skin care products, but the active ingredients of the skin care products are water-soluble antioxidants. It is known that water-soluble antioxidants are liable to oxidative deterioration and have a low oxidation resistance, and therefore they are often not effective in practical use.

Further, it is considered that the ultraviolet rays can be divided into three wavelength bands, i.e., long-wave ultraviolet ray UVA (320-400nm), medium-wave ultraviolet ray UVB (280-320nm), and short-wave ultraviolet ray UVC (200-280nm), wherein UVC hardly reaches the ground surface. Thus, the ultraviolet rays in sunlight consist mainly of UVA (95%) and a small amount of UVB (5%). UVA can produce singlet oxygen radicals and superoxide radicals at the same time, which can damage the skin. Although UVB is a small amount, it causes a large amount of damage, mainly acting on the epidermis and the superficial dermis of the skin, and induces the generation of superoxide radicals to damage the skin. Therefore, the design of anti-radiation skin care products needs to consider the problem of skin damage protection caused by both UVA and UVB ultraviolet rays.

Disclosure of Invention

The invention aims to overcome the defects of the prior art and provide a radiation-resistant skin care product capable of resisting UVA and UVB ultraviolet rays simultaneously and a preparation method thereof.

In order to solve the technical problems, the invention adopts the technical scheme that:

the anti-radiation skin care product comprises the following components in percentage by mass:

in the radiation-resistant skin care product, the humectant is further improved, and the humectant is at least one of sodium hyaluronate and polyglutamic acid, tremella polysaccharide, propylene glycol and butanediol;

the preservative is at least one of propyl hydroxybenzoate, iodopropynyl butylcarbamate and 2-phenoxyethanol;

the solubilizer is at least one of PEG20 hydrogenated castor oil, PEG20 glyceryl stearate, PEG60 hydrogenated castor oil, PEG60 glyceryl isostearate, polyglycerol-10 stearate and PEG/PPG-17/6 copolymer;

the thickening agent is at least one of hydroxyethyl cellulose, carboxymethyl cellulose and hydroxypropyl guar gum;

the skin conditioner is at least one of propolis extract, chamomile extract, ginseng root extract, yeast extract and houttuynia cordata extract;

the chelating agent is EDTA disodium;

the antioxidant is at least one of astaxanthin, lycopene and tea polyphenol;

the anti-allergy agent is dipotassium glycyrrhizinate;

the aromatic is at least one of water extract of flos Magnoliae, water extract of Aloe, and water extract of flos Rosae Rugosae.

In the radiation-resistant skin care product, further improvement is that the radiation-resistant skin care product also comprises a multifunctional transdermal absorption enhancer; the mass percentage content of the multifunctional transdermal absorption enhancer in the anti-radiation skin care product is 0.5-5%; the multifunctional transdermal absorption enhancer is a compound shown as a formula (I):

wherein in the formula (I), m is an integer of 0-20; x is an integer of 0-10, Y is an integer of 0-10, and X + Y is 3-12; z is an integer of 0 to 1000.

In the above anti-radiation skin care product, further improved, the multifunctional transdermal absorption enhancer is nanoparticles; the average particle size of the multifunctional transdermal absorption enhancer is 80 nm-150 nm.

In the above mentioned radiation-resistant skin care product, further improvement, the preparation method of the multifunctional percutaneous absorption enhancer comprises the following steps:

s1, dissolving chitosan in tetrahydrofuran, dropwise adding methanesulfonic acid chloride for reaction, removing tetrahydrofuran, adding methanesulfonic acid chloride, washing with water, drying, and removing chloroform to obtain a crude product A;

s2, dissolving the crude product A obtained in the step S1 in DMF, adding NaI for reaction, adding chloroform for terminating the reaction, washing with water, and performing suspended evaporation to obtain a crude product B;

s3, dissolving the crude product B obtained in the step S2 in DMF, adding sodium polyethylene glycol for reaction, adding water for terminating the reaction, dialyzing, and freeze-drying to obtain pegylated chitosan;

s4, dissolving the pegylated chitosan obtained in the step S3 in N, N-dimethylformamide, adding 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride for activation, adding a vitamin E-containing N, N-dimethylformamide solution for reaction, dialyzing, and freeze-drying to obtain vitamin E linked chitosan;

s5, dissolving the chitosan linked with the vitamin E prepared in the step S4 in tetrahydrofuran, adding hyaluronic acid, 1, 6-diisocyanatohexane and dibutyltin laurate to react, dialyzing, and freeze-drying to obtain the multifunctional transdermal absorption enhancer.

In the preparation method of the multifunctional transdermal absorption enhancer, the mass ratio of the chitosan, the methanesulfonic acid acyl chloride, the NaI and the polyethylene glycol sodium is 20: 4-8: 4-10: 7-12.

In the above-mentioned anti-radiation skin care product, further improvement is that in the step S1, the reaction is performed at 0 ℃; the reaction time is 6-24 h;

in the step S2, the reaction is carried out at 80 ℃; the reaction time is 12-48 h;

in the step S3, the reaction time is 6-24 h;

in the step S4, the mass ratio of the pegylated chitosan to the vitamin E in the vitamin E-containing N, N-dimethylformamide solution is 5: 2-10: 0.5-5; the ratio of the pegylated chitosan to the N, N-dimethylformamide is 1 g: 2 mL-10 mL; the activation is carried out under ice bath conditions; the activation temperature is 0-4 ℃; the activation time is 0.2 h-8 h; the reaction is carried out under stirring conditions; the reaction time is 12-36 h;

in the step S5, the mass ratio of the vitamin E-linked chitosan to hyaluronic acid to the 1, 6-diisocyanatohexane to the dibutyltin laurate is 5: 0.01-0.5: 0.1-2: 0.001-0.1; the ratio of the vitamin E-linked chitosan to tetrahydrofuran is 1 g: 2 mL-10 mL; the reaction is carried out under a protective atmosphere; the protective atmosphere is nitrogen or argon; the reaction temperature is 60-80 ℃; the reaction time is 6-48 h.

As a general technical concept, the present invention also provides a preparation method of the above-mentioned radiation-resistant skin care product, comprising the steps of:

(1) mixing a solubilizer, an antioxidant and a fragrance to prepare a mixture A; mixing sodium hyaluronate, polyglutamic acid and/or tremella polysaccharide to prepare a mixture B; mixing the rest humectant, chelating agent and thickening agent, heating to 85-95 ℃, fully dissolving, and keeping the temperature for 15-20 min to obtain a mixture C;

(2) cooling the mixture C prepared in the step (1) to 40-45 ℃, adding a skin conditioner and an anti-allergy agent, and stirring for dissolving to obtain a mixture D;

(3) and (3) keeping the temperature at 40-45 ℃, adding the preservative, the mixture A prepared in the step (1) and the mixture B into the mixture D, supplementing water, stirring, and cooling to room temperature to obtain the anti-radiation skin care product.

(a) mixing a solubilizer, an antioxidant and a fragrance to prepare a mixture A; mixing sodium hyaluronate, polyglutamic acid and/or tremella polysaccharide to prepare a mixture B; mixing the rest humectant, chelating agent and thickening agent, heating to 85-95 ℃, fully dissolving, and keeping the temperature for 15-20 min to obtain a mixture C;

(b) cooling the mixture C prepared in the step (a) to 40-45 ℃, adding a multifunctional transdermal absorption enhancer, a skin conditioner and an anti-allergy agent, and stirring for dissolving to obtain a mixture D;

(c) keeping the temperature at 40-45 ℃, adding the preservative, the mixture A prepared in the step (a) and the mixture B into the mixture D, supplementing water, stirring, and cooling to room temperature to obtain the anti-radiation skin care product.

Compared with the prior art, the invention has the advantages that:

(1) the invention provides a radiation-resistant skin care product which comprises the following components in percentage by mass: 16 to 20 percent of humectant, 0.01 to 0.2 percent of preservative, 0.2 to 1 percent of solubilizer, 0.1 to 0.5 percent of thickener, 1 to 3 percent of skin conditioner, 0.1 to 0.5 percent of chelating agent, 0.1 to 10 percent of antioxidant, 0.1 to 0.2 percent of aromatic, 0.1 to 2 percent of anti-allergic agent and the balance of water. In the invention, the solubilizer is used to increase the solubility of the antioxidant, and the skin conditioner is used to disturb the stratum corneum structure of the skin, so that the effective ingredients enter the skin; meanwhile, the contained moisturizer can increase the moisture content and the moisture retention of the skin. The thickening agent can increase the skin feel of the skin. The anti-radiation skin care product can protect the photodamage of the skin surface caused by radiation, and can enter deep organism circulation to protect the photodamage of deep skin; meanwhile, the skin care product has the functions of smoothing, tendering and resisting aging of skin, and has high safety and wide market prospect.

(2) The anti-radiation skin care product also comprises a multifunctional transdermal absorption enhancer, wherein the multifunctional transdermal absorption enhancer is a compound shown as a formula (I), and the multifunctional transdermal absorption enhancer is added, so that the skin absorption degree of active ingredients such as antioxidant and the like can be improved, and the anti-radiation capability of the skin care product is improved.

(3) The invention provides a preparation method of an anti-radiation skin care product, which comprises the steps of preparing a mixture A from a solubilizer, an antioxidant and an aromatic, preparing a mixture B from sodium hyaluronate and tremella polysaccharide, preparing a mixture C from propylene glycol, butanediol, a chelating agent and a thickening agent, preparing a mixture D from a skin conditioner and an anti-allergic agent of the mixture C, and finally mixing the mixture D, a preservative, the mixture A and the mixture B to prepare the anti-radiation skin care product. The preparation method has the advantages of simple process, convenient operation, low cost and the like, is suitable for large-scale preparation, and is beneficial to industrial application.

Detailed Description

The invention is further described below with reference to specific preferred embodiments, without thereby limiting the scope of protection of the invention.

The materials and equipment used in the following examples are commercially available. In the examples of the present invention, unless otherwise specified, the processes used were conventional processes, the equipment used were conventional equipment, and the data obtained were average values of three or more experiments.

Example 1

A radiation-resistant skin care product comprises the following components in every 100 Kg: 18Kg of humectant, 0.1Kg of preservative, 0.2Kg of solubilizer, 0.15Kg of thickener, 2Kg of skin conditioner, 0.2Kg of chelating agent, 5Kg of antioxidant, 0.1Kg of fragrance, 0.1Kg of anti-allergy agent, and the balance of water.

In the embodiment, the humectant consists of 0.2Kg of sodium hyaluronate, 0.2Kg of polyglutamic acid, 12.6Kg of propylene glycol and 5Kg of butanediol.

In this example, the preservative is composed of 0.05Kg of propyl hydroxybenzoate and 0.05Kg of 2-phenoxyethanol.

In the embodiment, the solubilizer comprises 0.1Kg of PEG60 hydrogenated castor oil and 0.05Kg of PEG60 glyceryl isostearate.

In this example, the thickener is hydroxyethyl cellulose.

In the embodiment, the skin conditioner comprises 0.5Kg of propolis extract, 0.5Kg of chamomile extract and 1Kg of ginseng root extract.

In this example, the chelating agent is disodium EDTA.

In the embodiment, the antioxidant consists of 1Kg of astaxanthin, 2Kg of lycopene and 2Kg of tea polyphenol.

In this embodiment, the anti-allergic agent is dipotassium glycyrrhizinate.

In this embodiment, the aromatic is 0.1Kg of water extract of magnolia.

The preparation method of the anti-radiation skin care product in the embodiment of the invention comprises the following steps:

(1) mixing hydrogenated castor oil PEG60 and glyceryl isostearate PEG60 with astaxanthin, lycopene, tea polyphenols and flavoring agent under stirring at high speed in emulsifying machine to obtain mixture A.

(2) And (3) putting the sodium hyaluronate and the polyglutamic acid into a stirring pot, stirring and dissolving to obtain a mixture B.

(3) Adding propylene glycol, butanediol, disodium EDTA and hydroxyethyl cellulose into a stirring pot, heating to 85 ℃ while stirring to fully dissolve the propylene glycol, the butanediol, the disodium EDTA and the hydroxyethyl cellulose, and keeping the temperature for 20 minutes to obtain a mixture C.

(4) Cooling the mixture C to 45 deg.C, sequentially adding propolis extract, flos Chrysanthemi Indici extract, Ginseng radix extract, and dipotassium glycyrrhizinate, stirring and dissolving to obtain mixture D.

(5) Keeping the temperature at 45 ℃, adding propyl hydroxybenzoate, 2-phenoxyethanol, the mixture A prepared in the step (1) and the mixture B prepared in the step (2) into the mixture D, adding water to 100Kg, fully stirring, cooling to room temperature, discharging, standing, and obtaining the anti-radiation skin care product.

Example 2

A radiation-resistant skin care product comprises the following components in every 100 Kg: 16Kg of humectant, 0.1Kg of preservative, 0.4Kg of solubilizer, 0.2Kg of thickener, 3Kg of skin conditioner, 0.2Kg of chelating agent, 6Kg of antioxidant, 0.2Kg of fragrance, 0.15Kg of anti-allergy agent, and the balance of water.

In the embodiment, the humectant consists of 0.1Kg of sodium hyaluronate, 0.3Kg of tremella polysaccharide, 11.6Kg of propylene glycol and 4Kg of butanediol.

In this example, the preservative is composed of 0.06Kg of propylparaben and 0.04Kg of iodopropynyl butylcarbamate.

In the embodiment, the solubilizer comprises 0.1Kg of polyglycerol-10 stearate, 0.2Kg of PEG/PPG-17/6 copolymer and 0.1Kg of PEG20 hydrogenated castor oil.

In this example, the thickener is hydroxypropyl cellulose.

In the embodiment, the skin conditioner comprises 1Kg of yeast extract, 1Kg of houttuynia cordata extract and 1Kg of ginseng root extract.

In this example, the chelating agent is disodium EDTA.

In the embodiment, the antioxidant consists of 2Kg of astaxanthin, 2Kg of lycopene and 2Kg of tea polyphenol.

In this embodiment, the anti-allergic agent is dipotassium glycyrrhizinate.

In this embodiment, the fragrance is an aqueous aloe extract.

(1) mixing polyglycerol-10 stearate, PEG/PPG-17/6 copolymer, PEG20 hydrogenated castor oil, astaxanthin, lycopene, tea polyphenols and aromatic under stirring at high speed in emulsifying machine to obtain mixture A.

(2) And (3) putting the sodium hyaluronate and the tremella polysaccharide into a stirring pot, stirring and dissolving to obtain a mixture B.

(3) Adding propylene glycol, butanediol, disodium EDTA and hydroxypropyl cellulose into a stirring pot, heating to 90 ℃ while stirring, fully dissolving, and keeping the temperature for 15 minutes to obtain a mixture C.

(4) Cooling the mixture C to 42 deg.C, sequentially adding yeast extract, herba Houttuyniae extract, and dipotassium glycyrrhizinate, stirring for dissolving to obtain mixture D.

(5) Maintaining the temperature at 42 ℃, adding propyl hydroxybenzoate, iodopropynyl butylcarbamate, the mixture A prepared in the step (1) and the mixture B prepared in the step (2) into the mixture D, adding water to 100Kg, fully stirring, cooling to room temperature, discharging, standing, and making into the anti-radiation skin care product.

Example 3

A radiation-resistant skin care product comprises the following components in every 100 Kg: 18Kg of humectant, 0.05Kg of preservative, 0.7Kg of solubilizer, 0.3Kg of thickener, 3Kg of skin conditioner, 0.1Kg of chelating agent, 8Kg of antioxidant, 0.2Kg of aromatic, 1Kg of anti-allergic agent, and the balance of water.

In the embodiment, the humectant consists of 0.15Kg of sodium hyaluronate, 0.3Kg of polyglutamic acid, 0.5Kg of tremella polysaccharide, 12Kg of propylene glycol and 5.05Kg of butanediol.

In this example, 0.03Kg of propylparaben and 0.02Kg of iodopropynyl butylcarbamate were used.

In the embodiment, the solubilizer consists of 0.2Kg of PEG20 hydrogenated castor oil, 0.2Kg of PEG60 glyceryl isostearate and 0.3Kg of PEG/PPG-17/6 copolymer.

In this example, the thickener is hydroxypropyl guar.

In the embodiment, the skin conditioner comprises 1Kg of propolis extract, 1Kg of ginseng root extract and 1Kg of yeast extract.

In this example, the chelating agent is disodium EDTA.

In the embodiment, the antioxidant consists of 2Kg of astaxanthin, 3Kg of lycopene and 3Kg of tea polyphenol.

In this embodiment, the anti-allergic agent is dipotassium glycyrrhizinate.

In this example, the fragrance is an aqueous rose extract.

(1) mixing PEG20 hydrogenated castor oil, PEG60 glyceryl isostearate, PEG/PPG-17/6 copolymer, astaxanthin, lycopene, tea polyphenols and aromatic under stirring at high speed in emulsifying machine to obtain mixture A.

(2) And putting the sodium hyaluronate, the polyglutamic acid and the tremella polysaccharide into a stirring pot, and stirring and dissolving to obtain a mixture B.

(3) Adding propylene glycol, butanediol, disodium EDTA and hydroxypropyl guar gum into a stirring pot, heating to 85 ℃ while stirring to fully dissolve the propylene glycol, the butanediol, the disodium EDTA and the hydroxypropyl guar gum, and preserving the temperature for 20 minutes to obtain a mixture C.

(4) Cooling the mixture C to 45 deg.C, sequentially adding propolis extract, Ginseng radix extract, yeast extract, and dipotassium glycyrrhizinate, stirring for dissolving, and making into mixture D.

(5) Keeping the temperature at 45 ℃, adding propyl hydroxybenzoate, iodopropynyl butylcarbamate, the mixture A prepared in the step (1) and the mixture B prepared in the step (2) into the mixture D, adding water to 100Kg, fully stirring, cooling to room temperature, discharging, and standing to obtain the anti-radiation skin care product.

Detection of proliferative Activity of FEK4 cells

FEK4 cells were seeded at 5000 cells/well in 96-well culture plates, 4 wells per group, at 37 deg.C, 5% CO₂Culturing in an incubator for 48 h. Cells were irradiated in groups according to the above experiment, and after 24 hours of irradiation, the culture was continued for 24 hours by replacing 1% MEM culture medium. Then, the stock culture was aspirated, 100. mu.l of MTS working solution (prepared in advance in a ratio of medium: MTS 10: 1) was added to each well, and incubation was continued for 2 hours. And (3) measuring the absorbance value of each hole on a microplate reader, storing the test result, performing data processing, and calculating the cell proliferation activity.

The anti-radiation skin care products prepared in the above examples 1-3 and commercial OSM European Shimmy pearl facial-repairing barrier cream (main components: pearl powder, American ginseng root extract, tea catechins, vitamin C, tremella extract, etc.) (BA 42301, European Shimmy group Limited, Zhejiang) were matched with each other at a ratio of 150KJ/m²Data on the protective effect of FEK4 cells against oxidative damage caused by uv light are shown in table 1.

TABLE 1 comparative data on the protective effect of different skin care products on the oxidative damage of FEK4 cells

In Table 1, water was used as a control (without UV irradiation), and the UV irradiation group was directly irradiated with full-band UV including UVA and UVB.

As can be seen from Table 1, the K value is 150KJ/m²The FEK4 cells were significantly damaged in the UV light irradiation group. Compared with a control group, the anti-radiation cosmetic prepared by the invention can obviously reduce the stress damage caused by ultraviolet rays, and the cell activity can be improved to more than 92% from 52%. The cell activity of the commercially available radiation-proof cosmetics is only 79 percent, which is obviously lower than that of the radiation-proof cosmetics.

Skin texture and skin color testing

400 consumers were randomly selected and divided into 4 groups, and the anti-radiation skin care products prepared in examples 1 to 3 and commercially available OSM pearl facial makeup base cream (main components: pearl powder, panax quinquefolius root extract, tea catechins, vitamin C, tremella extract, etc.) (zhejiang OSM group limited, BA42301) were continuously used for 40 days. The comparison of the skin of the consumers was performed using CN61M/DYD69-094 in a computer skin tester (Beijing Aiggeson Automation Co., Ltd.), and the results are shown in Table 2.

TABLE 2 comparison of consumer data for different skin care product applications (texture, skin tone in units of brightness/cm squared)

	Texture	Skin tone
			Examples1 prepared anti-radiation skin care product	8.8	9.2
Example 2 preparation of a radiation resistant skin Care product	9.2	8.9
			Example 3 preparation of a radiation resistant skin Care product	9.8	9.3
OSM European poem pearl beautifying and isolating cream	7.2	6.9
			Control group	6.1	5.6

In table 2, water was used as a control.

As can be seen from the results in Table 2, the radiation-resistant skin care product prepared by the invention has more obvious effects on skin damage caused by lower ultraviolet rays and skin protection compared with the commercially available radiation-resistant products.

Example 4

A radiation-resistant skin care product comprises the following components in every 100 Kg: 18Kg of humectant, 0.1Kg of preservative, 0.2Kg of solubilizer, 0.15Kg of thickener, 2Kg of skin conditioner, 0.2Kg of chelating agent, 5Kg of antioxidant, 0.1Kg of aromatic, 0.1Kg of anti-allergic agent, 5Kg of multifunctional transdermal absorption enhancer, and the balance of water.

In this example, the thickener is hydroxyethyl cellulose.

In this example, the chelating agent is disodium EDTA.

In this embodiment, the anti-allergic agent is dipotassium glycyrrhizinate.

In this embodiment, the aromatic is 0.1Kg of water extract of magnolia.

In this embodiment, the multifunctional skin penetration enhancer is a compound represented by formula (i):

in the present example, in the compound represented by the formula (I), m is 3, X is 3, Y is 6, and Z is 500.

In this embodiment, the multifunctional skin penetration enhancer is nanoparticles with an average particle size of 150 nm.

In this embodiment, the preparation method of the multifunctional transdermal absorption enhancer includes the following steps:

s1, dissolving 20g of chitosan in 100mL of tetrahydrofuran, dropwise adding 5g of methanesulfonic acid chloride at 0 ℃, reacting for 12 hours, performing suspension evaporation to remove the tetrahydrofuran, dissolving the obtained product in chloroform again, washing with water for 3 times (100 mL/time), drying with anhydrous sodium sulfate, and performing suspension evaporation to remove the chloroform to obtain 21g of crude product A. The crude product A was dissolved in 100mL of DMF, 6g of NaI was added, the reaction was heated at 80 ℃ for 24 hours, cooled, 100mL of chloroform was added to stop the reaction, washed 3 times with water (100mL each), dried over anhydrous sodium sulfate and evaporated to give crude product B. And dissolving the crude product B in DMF, adding 10g of sodium polyethylene glycol at room temperature, reacting for 12 hours, adding 100mL of water to stop the reaction, dialyzing by using a dialysis membrane to remove unreacted substances, and freeze-drying the obtained product to obtain the pegylated chitosan. In the preparation method of the pegylated chitosan, N in the structural formula of the chitosan is 6.

S2, weighing 5g of the PEGylated chitosan prepared in the step S1, dissolving in 30mLN, N-Dimethylformamide (DMF), adding 2.96g of 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride (EDC) under ice bath, activating for 2h under ice bath, dropwise adding 20mL of DMF solution containing vitamin E (containing 6.67g of vitamin E in the solution), and stirring at 25 ℃ (the stirring speed can be within 200-1000 rpm) for 24 h. Subsequent dialysis, followed by lyophilization, gave 10g of chitosan-linked vitamin E (CS-VE).

S3, dissolving 5g of the product obtained in the step S2 in 50mL of tetrahydrofuran, adding 0.2g of hyaluronic acid under the protection of nitrogen, adding 1.3g of 1, 6-diisocyanatohexane (HDI) and 10mg of dibutyltin laurate, reacting at 80 ℃ for 24h under the protection of nitrogen, adding excessive methanol to terminate the reaction, continuing to stir the reaction for 1h, and then adding diethyl ether to precipitate a solid, thereby obtaining 5.2g of the multifunctional transdermal absorption enhancer (CS-VE-HA).

(4) Cooling mixture C to 45 deg.C, sequentially adding multifunctional skin penetration enhancer, propolis extract, flos Chrysanthemi Indici extract, Ginseng radix extract, and dipotassium glycyrrhizinate, stirring and dissolving to obtain mixture D.

(5) Keeping the temperature at 45 ℃, adding propyl hydroxybenzoate, 2-phenoxyethanol, the mixture A prepared in the step (1) and the mixture B prepared in the step (2) into the mixture D, adding water to 100Kg, fully stirring, cooling to room temperature, discharging, and standing to obtain the anti-radiation skin care product.

Example 5

A radiation-resistant skin care product comprises the following components in every 100 Kg: 16Kg of humectant, 0.1Kg of preservative, 0.4Kg of solubilizer, 0.2Kg of thickener, 3Kg of skin conditioner, 0.2Kg of chelating agent, 6Kg of antioxidant, 0.2Kg of fragrance, 0.15Kg of anti-allergy agent, 5Kg of the multifunctional transdermal absorption enhancer prepared in example 4, and the balance of water.

In this example, the thickener is hydroxypropyl cellulose.

In this example, the chelating agent is disodium EDTA.

In this embodiment, the anti-allergic agent is dipotassium glycyrrhizinate.

In this embodiment, the fragrance is an aqueous aloe extract.

(4) Cooling the mixture C to 42 deg.C, sequentially adding the multifunctional skin penetration enhancer, yeast extract, herba Houttuyniae extract, and dipotassium glycyrrhizinate prepared in example 4, stirring for dissolving, and making into mixture D.

Example 6

A radiation-resistant skin care product comprises the following components in every 100 Kg: 18Kg of humectant, 0.05Kg of preservative, 0.7Kg of solubilizer, 0.3Kg of thickener, 3Kg of skin conditioner, 0.1Kg of chelating agent, 8Kg of antioxidant, 0.2Kg of fragrance, 1Kg of anti-allergy agent, 5Kg of multifunctional transdermal absorption enhancer prepared in example 4, and the balance of water.

In this example, the thickener is hydroxypropyl guar.

In this example, the chelating agent is disodium EDTA.

In this embodiment, the anti-allergic agent is dipotassium glycyrrhizinate.

In this example, the fragrance is an aqueous rose extract.

(4) Cooling the mixture C to 45 deg.C, sequentially adding the multifunctional skin penetration enhancer, propolis extract, Ginseng radix extract, yeast extract, and dipotassium glycyrrhizinate prepared in example 4, stirring and dissolving to obtain mixture D.

The moisture-retaining and moisturizing abilities of the radiation-resistant skin care products prepared in examples 4 to 6 were examined, as shown in table 3.

TABLE 3 comparative data on moisturizing and hydrating ability of radiation resistant skin care products using transdermal absorbents

	Water content%	The water loss rate%
			Example 4 preparation of a radiation resistant skin Care product	300	6
Radiation resistant skin care product prepared in example 5	198	9
			Radiation resistant skin care product prepared in example 5	150	11
OSM European poem pearl beautifying and isolating cream	110	14
			Control group	100	15

In table 3, water was used as a control.

As can be seen from the results in Table 3, the anti-radiation skin care product prepared by the invention has more obvious effects on moisturizing and moisturizing of the skin care product compared with the commercially available anti-radiation product.

The above examples are merely preferred embodiments of the present invention, and the scope of the present invention is not limited to the above examples. All technical schemes belonging to the idea of the invention belong to the protection scope of the invention. It should be noted that modifications and embellishments within the scope of the invention may be made by those skilled in the art without departing from the principle of the invention, and such modifications and embellishments should also be considered as within the scope of the invention.

Claims

1. The radiation-resistant skin care product is characterized by comprising the following components in percentage by mass:

2. the radiation-resistant skin care product of claim 1, wherein the moisturizer is at least one of sodium hyaluronate and polyglutamic acid, tremella polysaccharide, propylene glycol and butylene glycol;

the chelating agent is EDTA disodium;

the antioxidant is at least one of astaxanthin, lycopene and tea polyphenol;

the anti-allergy agent is dipotassium glycyrrhizinate;

3. The radiation-resistant skin care product according to claim 1 or 2, further comprising a multifunctional skin absorption enhancer; the mass percentage content of the multifunctional transdermal absorption enhancer in the anti-radiation skin care product is 0.5-5%; the multifunctional transdermal absorption enhancer is a compound shown as a formula (I):

4. The radiation-resistant skin care product according to claim 3, wherein the multifunctional skin penetration enhancer is a nanoparticle; the average particle size of the multifunctional transdermal absorption enhancer is 80 nm-150 nm.

5. The radiation-resistant skin care product according to claim 4, wherein the multifunctional skin penetration enhancer is prepared by a method comprising the following steps:

6. The radiation-resistant skin care product according to claim 5, wherein in the preparation method of the multifunctional transdermal absorption enhancer, the mass ratio of the chitosan, the methanesulfonic acid chloride, the NaI and the sodium polyethylene glycol is 20: 4-8: 4-10: 7-12.

7. The radiation-resistant skin care product according to claim 6, wherein in step S1, the reaction is carried out at 0 ℃; the reaction time is 6-24 h;

in the step S3, the reaction time is 6-24 h;

8. A method of preparing a radiation resistant skin care product according to claim 2 comprising the steps of:

9. A method for preparing a radiation-resistant skin care product according to any one of claims 3 to 7, comprising the steps of: