CN108498413A - A kind of cosmetic composition containing whitening compound - Google Patents
A kind of cosmetic composition containing whitening compound Download PDFInfo
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- CN108498413A CN108498413A CN201810730984.7A CN201810730984A CN108498413A CN 108498413 A CN108498413 A CN 108498413A CN 201810730984 A CN201810730984 A CN 201810730984A CN 108498413 A CN108498413 A CN 108498413A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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Abstract
The present invention relates to cosmetic fields, and in particular to a kind of cosmetic composition containing whitening compound.The composition includes niacinamide 1 3%, whitening compound 1 4%, citrus bark extract 0.5 1.5%, ursin 0.1 0.5% and umbel parthenium extract 0.1 5% etc..Wherein the ingredient of whitening compound is water, butanediol, ursin, citric acid, sodium sulfite, Acetyl Tyrosine, aaron's beard extract, peony root extractive, aminopropanol ascorbic acid phosphoric acid esters, radix scutellariae root extract, glutathione, hydrolysis mirabalan.It is characteristic of the invention that in the selected raw material with synergy of each whitening node, there is collaboration whitening effect；It can inhibit tyrosinase activity, inhibit melanin transfer, and energy bright color, while can also jointly act synergistically in each node in whitening path, be finally reached safety, effective and stable whitening effect.
Description
Technical field
The present invention relates to a kind of cosmetics, belong to daily technical field of skin care, multiple containing whitening more particularly to one kind
Close the cosmetic composition of object.
Background technology
Our East Asia women are from ancient times with Bai Weimei, in order to which whitening has used many methods.Such as milk is taken a shower.Even with
Many virose substances, such as the lead mercury surface application of early stage, until eighties of last century is also used in someone.
Since modern age, many whitening agents have been selected in people's exploitation.Currently, one of the active matter of most effective skin whitening is
Quinhydrones, but quinhydrones molecular weight is small, destroys melanocyte, and may induce inflammation.So quinhydrones is most of in the world
Country is limited by stringent legislation, is prohibited to be used as components of cosmetics.
Rhododendrol was once the leading whitening active object of a Japanese famous cosmetics company.It is produced behind but excessively
The problem of whitening.Later the said firm apologizes in view of this problem to client.
Azelaic acid is a kind of aliphatic acid of naturally occurring medium chain.It is a kind of important skin-whitening agents, there is suppression
The effect of tyrosinase processed.But application when there is also some technologies and formula in terms of the problem of.First, azelaic acid must be
It is just effective when high concentration.Azelaic acid is insoluble at high concentrations, keeps the cosmetics quality of preparation poor, and especially very thick system is very
Difficulty is smeared out.Secondly, the fusing point of azelaic acid is higher, and ordinary circumstance is prepared more difficult.
L-AA and its derivative and licorice are all easy discoloration, and stability still has no small ask
Topic is also to require special attention when in use.
Some present illegal businessman add glucocorticoid for short-term profit in the cosmetics such as facial mask.It can be short
The tender effect compacted in vain is generated in phase, but is used for a long time and very serious consequence is generated to the skin of people.
With the development of modern science and technology, people are more and more deep to the understanding of colour of skin system.The depth of skin color
Regulated and controled by many factors, but the main content for still depending on melanin and distribution.Melanin is generated by melanocyte.It is black
Plain cell is one of important composition cell of skin, is in dendrite, and the melanin formed into the cell is transported by dendrite
Into corneocyte.It is with 1：36 ratios constitute an epidermis unit with keratinocyte, are present in basal layer of epidermis, black
Plain cell determines the skin color depth, while absorbable ultraviolet light by synthesis of melanin, makes damage of the body from ultraviolet light.
The specific forming process of melanin is as follows：When ultraviolet light irradiate skin when, horn cell be stimulated generate inflammation secretion inflammation because
Son and histamine etc., while DNA is damaged and generates free radicals.Melanocyte is broken up by stimulations such as inflammatory factor, free radicals
Accelerate.Internal tyrosinase activity increases, and tyrosine is converted into DOPA under the catalytic action of tyrosinase, is further converted to
DOPA quinone, DOPA quinone are finally translated into melanin through radical reaction.Melanosome is transmitted to horn cell through dendron.Most
The calmness of pigment in skin is caused eventually.
Since in the recent period, many companies develop some lightening compositions, are more some effect simple superposition in fact
Product, it is difficult to achieve the desired results.
How to develop efficient, safe and stablizing and with synergy whitening regime becomes present cosmetic industry
Where one difficult point.
Invention content
Insufficient existing for above-mentioned technology in order to make up, the object of the present invention is to provide a kind of makeups containing whitening compound
Product composition can not only inhibit, emphasis effect in terms of melanin transfer in tyrosinase, but also can cooperate with work in other respects
With can not only reach whitening effect outstanding but also can be with equilibrium coordination without causing negative-feedback phenomenon.
Present invention employs technical solutions below：
A kind of cosmetic composition containing whitening compound, by mass percentage, including following components：
Niacinamide 1-3%；
Whitening compound 1-4%, the wherein ingredient of whitening compound are water, butanediol, ursin, citric acid, sulfurous
Sour sodium, Acetyl Tyrosine, aaron's beard extract, peony root extractive, aminopropanol ascorbic acid phosphoric acid esters, scutellariae,radix carry
Take object, glutathione, hydrolysis mirabalan；
Preferably, by mass percentage, the composition includes following components：
Niacinamide 2-3%；
Whitening compound 2-4%, the wherein ingredient of whitening compound are water, butanediol, ursin, citric acid, sulfurous
Sour sodium, Acetyl Tyrosine, aaron's beard extract, peony root extractive, aminopropanol ascorbic acid phosphoric acid esters, scutellariae,radix carry
Take object, glutathione, hydrolysis mirabalan；
Preferably, by mass percentage, which selects excipient matrix by one or more below
Component is constituted：
As further preferably, by mass percentage, which selects excipient matrix by below a kind of or several
Kind component is constituted：
Niacinamide used by the composition is high-purity raw, and Nicotinic Acid Content is less than 100PPM.It is inhibiting black
Ferritic shifts, and effect protrudes in terms of accelerating damaged dna reparation.In this whitening breast when niacinamide content is less than 1%, through surveying
Examination, whole whitening effect weaken very much.When niacinamide content is more than 3%, tested through cell in vitro, cytotoxicity is too big.
Therefore 1-3% is selected.
The whitening compound that the composition uses is water, butanediol, ursin, citric acid, sodium sulfite, acetyl junket ammonia
Acid, aaron's beard extract, peony root extractive, aminopropanol ascorbic acid phosphoric acid esters, radix scutellariae root extract, gluathione
Peptide, hydrolysis mirabalan.The ratio of wherein each component is about：Water 40-50%, butanediol 40-50%, ursin 0.3-0.8%,
Citric acid 0.3-0.6%, sodium sulfite 0.4-0.6%, Acetyl Tyrosine 0.1-0.3%, aaron's beard extract 0.01-
0.3%, peony root extractive 0.01-0.2%, aminopropanol ascorbic acid phosphoric acid esters 0.001-0.1%, radix scutellariae root extract
0.01-0.1%, glutathione 0.001-0.1%, hydrolysis mirabalan 0.01-0.6%.,
In the composition：
Absorb ultraviolet light --- ursin, radix scutellariae root extract；
Inhibit inflammatory factor activity --- radix scutellariae root extract, peony root extractive；
Inhibit tyrosinase activity --- ursin；
The polymerization of melanin autoxidation and reduction melanin is inhibited to be formed --- aaron's beard extract, scutellariae,radix
Extract, aminopropanol ascorbic acid phosphoric acid esters；
Repair UV-induced DNA damage --- aaron's beard extract；
Promote synthesis brown-black element rather than eumelanin --- glutathione；
Tyrosinase --- Acetyl Tyrosine is competed with tyrosine；
Promote hyperplasia and cutin update --- aminopropanol ascorbic acid phosphoric acid esters, citric acid；
Melanin is inhibited to be annexed by horn cell --- hydrolysis mirabalan.
By the research and experimental analysis to above-mentioned mechanism, in this composition, when this whitening compound dosage is less than 1%
When, this composition whitening effect unobvious.When this whitening compound dosage is higher than 4%, the heat-resisting fast light stabilization of this composition
Property be deteriorated.Therefore select dosage for 1-4%.
The citrus bark extract of use uses carbon dioxide supercritical extraction technology, the orange peel extraction of this technology extraction
Object general flavone content can be more than 2.5%, hence it is evident that the content than other modes extraction is high.It is energy-efficient excellent and with environmental-friendly
Point.Effect of the citrus bark extract in this composition, which is collaboration other components, keeps skin brighter and cleaner bright.And its general flavone amount
And type is a standard of its quality.The citrus bark extract used in this composition uses carbon dioxide supercritical extraction skill
The orange peel extractive total flavone content of art, this technology extraction can be more than 2.5%, hence it is evident that than the content of other modes extraction
It is high.And there is environmental-friendly, energy saving advantage.In the experiment of composition, the content of citrus bark extract is less than 0.2%
When, role is small, and when its content is more than 1.5%, this composition is easy discoloration when illumination and 45 DEG C are heat-resisting, therefore selects
Select 0.5-1.5%.
It is the cosmetics-stage raw material that content surpasses 98% that ursin is selected in this composition, has and inhibits melanin production mistake
The ability of key enzyme-tyrosinase activity in journey also has the effect of absorbing ultraviolet light.Due to ursin in structure with junket
Propylhomoserin have similitude, therefore during tyrosine synthesis of melanin can with tyrosine competitive binding tyrosinase, from
And reduce the effect of tyrosinase catalysis tyrosine synthesis of melanin.When the content of ursin is less than 0.1% in this whitening breast,
Risen whitening effect very little；When its content is more than 0.8%, this composition is variable red during storage.Therefore selection 0.1-
0.5%.
The high extract of umbel selected in this composition, from the plant of European high altitude localities plantation.Through
The effect of test has and efficiently removes very much free radical, anti-inflammatory.Experiment proves that in the compositions of the present invention with
Other compositions cooperation is with synergistic whitening function.
Solvent in the present composition is deionized water；
Moisturizer in the present composition including but not limited to glycerine, propylene glycol, 1,3- propylene glycol, butanediol, oneself two
Alcohol, 1,2- pentanediols, pungent glycol, sorbierite and hexyl glycerine, trehalose, glycine betaine, Sodium Hyaluronate, carbohydrate are different with dividing
Structure body, urea, allantoin, panthenol, glyceryl acrylate/acrylic copolymer, glucan and combinations thereof；
Thickener in the present composition is cold including but not limited to xanthans, carbomer, cellulose and its modifier, knot
Glue, polyacrylamide, sodium acrylate/sodium acryloyldimethyl taurate copolymers, hydroxy-ethyl acrylate/acryloyldimethyl ox
Sodium sulfonate copolymers, polyacrylate -13, acrylamide/acrylic amine copolymer, hydroxy-ethyl acrylate/acryloyldimethyl
Taurate Copolymer, acryloyldimethyl taurine ammonia/VP copolymers and combinations thereof；
Emulsifier in the present composition including but not limited to cetostearyl alcohol, hexadecanol, stearyl alcohol, docosanol,
Arachidic alcohol, docosyl alcohol, stearine, Cetyl Phosphate potassium, methyl sesquistearate, PEG-20 methyls times
Semi-solid fat acid esters, hydrolecithin, cetostearyl alcohol olive oleate, the smooth olive oleate of sorb, alkyl glucosides glycoside, sucrose
Fatty acid ester, polyglyceryl fatty acid ester class, polyethylene glycol stearate class, poly alkyl alcohol ethers, gathers stearoyl-glutamic acid sodium
Poly oxyalkylene glycol class and combinations thereof；
Emollient in the present composition is including but not limited to vegetable fat, animal fat, Synthetic Oil, mineral grease
And combinations thereof；
Ultra-violet absorber in the present composition including but not limited to BHT, TINOGARD TT, VE, sun-screening agent and its
Composition；
Skin conditioning agent in the present composition is including but not limited to agent of releiving, anti-sensitizer and combinations thereof；
Chelating agent in the present composition is including but not limited to EDTA-2NA, EDTA-4NA and combinations thereof；
Preservative in the present composition is including but not limited to Phenoxyethanol, parabens, organic acid, imidazolidine
Base ureas and combinations thereof.
It is analyzed from mechanism, the present composition is by adopting the above-described technical solution, can be to avoid skin because of some
The enhancing suddenly of the signal of whitening node obtains the phenomenon that negative-feedback signal (melanin reduces, and needs mass production melanin).
Not only whitening effect can be protruded in several whitening key points, but also can be controlled on the node of entire whitening chain so that human body
The generation of the reduction melanin of integumentary system harmony is transmitted to reach whitening skin lightening result.Experimental data also turns out, of the invention
Have between each component and work in coordination, synergistic effect can obtain whitening effect outstanding.
Specific implementation mode
A part of specific embodiment is set forth below, and the present invention will be described, these examples are served only for making into one the present invention
The explanation of step is not used to limit the present invention, does not represent limiting the scope of the invention.Other people make according to the present invention
Some it is nonessential modification and adjustment still fall within protection scope of the present invention.Unless otherwise instructed, percentage (%) below
It is mass percentage.
The present invention can absorb ultraviolet light, inhibit inflammatory factor, repair damaged dna, remove free radical, inhibit tyrosine
Enzyme restores melanin, inhibits melanin to be shifted by phagocytosis, and then achieve the purpose that whitening.The present invention both can be in tyrosinase
Inhibit, emphasis effect in terms of melanin transfer, and can act synergistically in other respects, can both reach whitening effect outstanding
It again can be with equilibrium coordination without causing negative-feedback phenomenon.
Embodiment 1-3
A kind of whitening cosmetic compound containing whitening compound, is made lotion, and raw material components proportioning, reference examples are former
Expect the content of component proportion and blank example component proportion, as shown in table 1 below.
1 embodiment 1-3 of table, reference examples 1-5 and blank example (unit：Quality %)
The process for making of the whitening emulsion composition of the present invention can be expressed as follows：
A kind of preparation method of combinations of the above object, this approach includes the following steps：
1) kettle is added in deionized water, puts into carbomer under fast stirring, it is scattered that glycerine is added after stirring swelling
Xanthan gum, 1.3- butanediols, EDTA-2NA, allantoin are warming up to 85 DEG C, insulated and stirred 20 minutes；
2) by stereth -2, stereth -21, cetostearyl alcohol, caprylic/capric triglyceride, myristic acid
Isopropyl ester, dimethyl silicone polymer put into oil phase pot, are warming up to 80 DEG C, insulated and stirred 20 minutes；
3) kettle and oil cauldron raw material are pumped into emulsification pot, high speed homogenization 10 minutes, insulated and stirred 20 minutes is cooled to 45
DEG C, the good niacinamide of ursin, deionized water dissolving that triethanolamine, deionization have dissolved, whitening compound, orange peel is added
The high extract of extract, umbel, essence/preservative stir 20 minutes, are cooled to room temperature, discharge after inspection qualification, are made
Lotion skin care item.
Ingredient 9- whitening compounds therein, raw material components formula and content are as shown in table 2 below.
The raw material components formula of 2 whitening compound of table
1, tester：80 people's healthy womens (25~45 years old) are divided into 8 groups, and every group is respectively 10 people；Every group uses formula of the same race
Product.
2, test zone：Face's (left face blank sample, right face reference examples sample or embodiment sample)；
3, it uses：Sooner or later twice daily, it persistently uses 4 weeks
4, test equipment：DelfinSkinColorCatch (Finland)
5, effectiveness indicator：Measure the variation (Δ L*) of colour brightness, ITA degree, L* values (brightness), ITA degree (face in the present invention
Color individual type angle), it is primarily used to index.
Equation (1)：[L* (reference examples or embodiment product carry out after testing 1 month)-L* (carries out on-test to Δ L*=
Before)]-[L* (after blank product carries out experiment 1 month)-L* (before carrying out on-test)]；
(2)：ITA degree (represents coloration entire change situation, ITA ° of value is bigger, and the colour of skin is more shallow.)
5, test effect is as shown in table 3 below：
Found out by the result of table 3, lightening compositions of the present invention have by the synergistic effect between component than more significant
Whitening, the effect of bright color, the effect than single whitening composition becomes apparent from.
Embodiment 4
A kind of whitening emulsion composition, raw material components proportioning, content of the reference examples raw material components with when blank example, such as
Shown in the following table 4.
4 embodiment 4 of table, reference examples 5-14 and blank example (unit：Quality %)
The process for making of the present composition is same as above.
Ingredient 16- whitening compounds therein, raw material components formula and content are as shown in table 5.
The raw material components formula of 5 whitening compound of table
| Ingredient names | Content (weight %) |
| Water | 48.9930 |
| Butanediol | 48.7511 |
| Ursin | 0.4750 |
| Citric acid | 0.4750 |
| Sodium sulfite | 0.4750 |
| Acetyl Tyrosine | 0.1425 |
| Aaron's beard extract | 0.1188 |
| Peony root extractive | 0.0855 |
| Aminopropanol ascorbic acid phosphoric acid esters | 0.04725 |
| Radix scutellariae root extract | 0.0428 |
| Glutathione | 0.0048 |
| Hydrolyze mirabalan | 0.3890 |
Compliance test result test example (whitening evaluation)
1, tester：77 people's healthy womens (25~45 years old) are divided into 11 groups, and every group is respectively 7 people, and every group uses formula of the same race
Product.
2, test zone：Face's (left face blank sample, right face reference examples sample or embodiment sample)；
3, it uses：Sooner or later twice daily, it persistently uses 4 weeks；
4, test equipment：DelfinSkinColorCatch (Finland)；
5, effectiveness indicator：Measure the variation (Δ L*) of variation, the ITA degree of colour brightness, L* values (brightness) in the present invention,
ITA degree (color individual type angle), is primarily used to index.
Equation (1)：[L* (reference examples or embodiment product carry out after testing 1 month)-L* (carries out on-test to Δ L*=
Before)]-[L* (after blank product carries out experiment 1 month)-L* (before carrying out on-test)]；
(2)：ITA degree (represents coloration entire change situation, ITA ° of value is bigger, and the colour of skin is more shallow.)
| ITA ° of range | Skin color is classified |
| 55–90 | Very light are very shallow |
| 41–54 | Light is shallow |
| 28–40 | Intermediate is medium |
| 10–27 | Tanned is tanned |
| -30–9 | Brown brown |
| -90–-29 | - 29Dark is dark-coloured |
6, test effect is as shown in table 6 below：
Found out by the result of table 6, the present composition has relatively significant more beautiful by the synergistic effect between component
In vain, the effect of bright color becomes apparent from than two kinds, three kinds or four kinds at the whitening effect of subassembly.
Security test
1, number is tested：Totally 30 people, male 3 people, 27 people of female；Minimal ages：24 years old, max age：45
Year；35.73 ± 7.15 years old aspiration inclusion criteria of average age.
2, test method：Embodiment 1-4 does patch test.Qualified spot is selected to try device, in enclosed type patch test method,
Tested material about 0.020~0.025mL is placed in spot examination device, external application medical adhesive tape is pasted on subject back, is gone after 24 hours
Except tested material, observation dermoreaction in 0.5,24,48 hour, is pressed after removing patch《Cosmetics safety technical specification》
Dermoreaction grade scale records its result in (version in 2015).
3, evaluation criteria such as the following table 7：
7 skin adverse reaction grade scale of table
The result of table 7 is shown：Human skin enclosed type patch test results show that 0 positive reaction, root occurs in 30 people
According to《Cosmetics safety technical specification》Regulation, the tested material will not cause skin bad this batch subject in (version in 2015)
Reaction.
Stability test
1, stability test sample：3 product of embodiment.
2, test method：Inner quality standard (illumination 1 month, high/low temperature are tested 3 months), higher than national standard, professional standard.
3, test result is as follows table 8
The result of table 8 is shown：The present composition has good stability on products application.
The above described is only a preferred embodiment of the present invention, be not intended to limit the present invention in any form, therefore
It is every without departing from technical solution of the present invention content, simply repaiied to any made by above example according to the technical essence of the invention
Change, equivalent variations and modification, in the range of still falling within technical solution of the present invention.
Claims (10)
1. a kind of cosmetic composition containing whitening compound, which is characterized in that include each group of following mass percent meter
Point：
Niacinamide 1-3%；
Whitening compound 1-4%, the wherein ingredient of whitening compound be water, butanediol, ursin, citric acid, sodium sulfite,
Acetyl Tyrosine, aaron's beard extract, peony root extractive, aminopropanol ascorbic acid phosphoric acid esters, radix scutellariae root extract,
Glutathione, hydrolysis mirabalan；
2. the cosmetic composition according to claim 1 containing whitening compound, which is characterized in that include following quality
The each component of percentages：
Niacinamide 2-3%；
Whitening compound 2-4%, the wherein ingredient of whitening compound be water, butanediol, ursin, citric acid, sodium sulfite,
Acetyl Tyrosine, aaron's beard extract, peony root extractive, aminopropanol ascorbic acid phosphoric acid esters, radix scutellariae root extract,
Glutathione, hydrolysis mirabalan；
3. the cosmetic composition according to claim 1 or 2 containing whitening compound, it is characterised in that：The composition
Excipient matrix is selected to be made of one or more of components below：
4. the cosmetic composition according to claim 3 containing whitening compound, it is characterised in that：The composition selects auxiliary material
Matrix is made of component below：
5. the cosmetic composition according to claim 1 or 2 containing whitening compound, it is characterised in that：The cigarette of use
Amide is the cosmetic material that Nicotinic Acid Content is less than 100PPM.
6. the cosmetic composition according to claim 1 or 2 containing whitening compound, which is characterized in that its described U.S.
White compound includes that the ratio of each component is：
Water 40-50%, butanediol 40-50%, ursin 0.3-0.8%, citric acid 0.3-0.6%, sodium sulfite 0.4-
0.6%, Acetyl Tyrosine 0.1-0.3%, aaron's beard extract 0.01-0.3%, peony root extractive 0.01-0.2%,
Aminopropanol ascorbic acid phosphoric acid esters 0.001-0.1%, radix scutellariae root extract 0.01-0.1%, glutathione 0.001-0.1%,
Hydrolyze mirabalan 0.01-0.6%.
7. the cosmetic composition according to claim 1 or 2 containing whitening compound, it is characterised in that：The citrus
Bark extract uses carbon dioxide supercritical extraction technology；
The ursin is the cosmetics-stage raw material that content surpasses 98%；
The umbel parthenium extract, from the plant of European high altitude localities plantation.
8. the cosmetic composition according to claim 4 containing whitening compound, it is characterised in that：The present composition
In moisturizer be selected from：Glycerine, propylene glycol, 1,3- propylene glycol, butanediol, hexylene glycol, 1,2- pentanediols, pungent glycol, sorbierite,
And hexyl glycerine, trehalose, glycine betaine, Sodium Hyaluronate, carbohydrate isomer, urea, allantoin, panthenol, glycerine third
It is one or more in olefin(e) acid ester/acrylic copolymer, glucan and combinations thereof；
The thickener is selected from：Xanthans, carbomer, cellulose and its modifier, gellan gum, polyacrylamide, sodium acrylate/
Sodium acryloyldimethyl taurate copolymers, hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers, polyacrylic acid
Ester -13, acrylamide/acrylic amine copolymer, hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers, acryloyl
It is one or more in dimethyltaurine ammonia/VP copolymers and combinations thereof；
The emulsifier is selected from：Cetostearyl alcohol, hexadecanol, stearyl alcohol, docosanol, arachidic alcohol, docosyl alcohol, glycerol stearate
Ester, Cetyl Phosphate potassium, methyl sesquistearate, PEG-20 methyls sesquistearate, hydrolecithin, whale
Wax stearyl alcohol olive oleate, Sorbitan fatty acid esters class, polysorbate esters, alkyl glucosides glycoside, sucrose-fatty esters,
Stearoyl-glutamic acid sodium, polyglyceryl fatty acid ester class, polyethylene glycol stearate class, poly alkyl alcohol ethers, the poly- silicon of polyethylene glycol
It is one or more in oxygen alkanes and combinations thereof；
The emollient is selected from：One kind or more in vegetable fat, animal fat, Synthetic Oil, mineral grease and combinations thereof
Kind；
The ultra-violet absorber is selected from：It is one or more in BHT, TINOGARD TT, VE, sun-screening agent and combinations thereof；
The skin conditioning agent is selected from：It releives one or more in agent, anti-sensitizer and combinations thereof；
The chelating agent is selected from：It is one or more in EDTA-2NA, EDTA-4NA and combinations thereof；
The preservative is selected from：One in Phenoxyethanol, parabens, organic acid, imidazolidinyl ureas and combinations thereof
Kind is a variety of.
9. a kind of cosmetics, this is used for cosmetic in whitening, bright color, it is characterised in that：The cosmetics include claim 1 or
A kind of cosmetic composition described in 2.
10. cosmetics according to claim 9, it is characterised in that：The cosmetics are that face cream, facial treatment milk, skin care are solidifying
Glue, facial treatment essence or surfactant.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810730984.7A CN108498413B (en) | 2018-07-05 | 2018-07-05 | Cosmetic composition containing whitening compound |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810730984.7A CN108498413B (en) | 2018-07-05 | 2018-07-05 | Cosmetic composition containing whitening compound |
Publications (2)
| Publication Number | Publication Date |
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| CN108498413A true CN108498413A (en) | 2018-09-07 |
| CN108498413B CN108498413B (en) | 2020-03-24 |
Family
ID=63404219
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|---|---|---|---|
| CN201810730984.7A Active CN108498413B (en) | 2018-07-05 | 2018-07-05 | Cosmetic composition containing whitening compound |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108498413B (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108852999A (en) * | 2018-09-28 | 2018-11-23 | 广东温和堂健康科学有限公司 | A kind of formula and technique of Xinhui citrus reticulata flower extract liquor production facial mask |
| CN109464366A (en) * | 2019-01-02 | 2019-03-15 | 吉林大学 | A kind of composition and its preparation method and application for removing skin splash |
| CN110585079A (en) * | 2019-09-09 | 2019-12-20 | 北京爸爸的选择科技有限公司 | Radiation-resistant composition containing food-borne peptide and radiation-resistant emulsion thereof |
| CN110812271A (en) * | 2019-11-16 | 2020-02-21 | 王洪波 | Polypeptide whitening and spot-fading essence and preparation method thereof |
| CN111743829A (en) * | 2020-06-04 | 2020-10-09 | 惠州市康维健生物科技有限公司 | Whitening cosmetic composition and preparation method thereof |
| CN112891278A (en) * | 2021-03-19 | 2021-06-04 | 河南董欣生物科技有限公司 | Whitening composition, preparation method and application |
| CN114533613A (en) * | 2022-02-23 | 2022-05-27 | 厦门金泰生物科技有限公司 | Whitening cosmetic composition and preparation method and application thereof |
| CN115944577A (en) * | 2022-12-29 | 2023-04-11 | 羽楠(广州)化妆品有限公司 | Whitening composition and application thereof, whitening cosmetic and preparation method thereof |
| CN116807928A (en) * | 2023-02-08 | 2023-09-29 | 杭州清潭维艾国际贸易有限公司 | Whitening composition containing plant essential oil and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105411931A (en) * | 2015-12-09 | 2016-03-23 | 上海新高姿化妆品有限公司 | Whitening cosmetic composition |
| WO2017102589A1 (en) * | 2015-12-14 | 2017-06-22 | Dsm Ip Assets B.V. | Composition comprising niacinamide and alpha-arbutin for skin lightening |
-
2018
- 2018-07-05 CN CN201810730984.7A patent/CN108498413B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105411931A (en) * | 2015-12-09 | 2016-03-23 | 上海新高姿化妆品有限公司 | Whitening cosmetic composition |
| WO2017102589A1 (en) * | 2015-12-14 | 2017-06-22 | Dsm Ip Assets B.V. | Composition comprising niacinamide and alpha-arbutin for skin lightening |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108852999A (en) * | 2018-09-28 | 2018-11-23 | 广东温和堂健康科学有限公司 | A kind of formula and technique of Xinhui citrus reticulata flower extract liquor production facial mask |
| CN109464366A (en) * | 2019-01-02 | 2019-03-15 | 吉林大学 | A kind of composition and its preparation method and application for removing skin splash |
| CN110585079A (en) * | 2019-09-09 | 2019-12-20 | 北京爸爸的选择科技有限公司 | Radiation-resistant composition containing food-borne peptide and radiation-resistant emulsion thereof |
| CN110812271A (en) * | 2019-11-16 | 2020-02-21 | 王洪波 | Polypeptide whitening and spot-fading essence and preparation method thereof |
| CN111743829A (en) * | 2020-06-04 | 2020-10-09 | 惠州市康维健生物科技有限公司 | Whitening cosmetic composition and preparation method thereof |
| CN112891278A (en) * | 2021-03-19 | 2021-06-04 | 河南董欣生物科技有限公司 | Whitening composition, preparation method and application |
| CN112891278B (en) * | 2021-03-19 | 2023-03-07 | 河南董欣生物科技有限公司 | Whitening composition, preparation method and application |
| CN114533613A (en) * | 2022-02-23 | 2022-05-27 | 厦门金泰生物科技有限公司 | Whitening cosmetic composition and preparation method and application thereof |
| CN115944577A (en) * | 2022-12-29 | 2023-04-11 | 羽楠(广州)化妆品有限公司 | Whitening composition and application thereof, whitening cosmetic and preparation method thereof |
| CN116807928A (en) * | 2023-02-08 | 2023-09-29 | 杭州清潭维艾国际贸易有限公司 | Whitening composition containing plant essential oil and preparation method thereof |
| CN116807928B (en) * | 2023-02-08 | 2024-06-04 | 杭州清潭维艾国际贸易有限公司 | Whitening composition containing plant essential oil and preparation method thereof |
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|---|---|
| CN108498413B (en) | 2020-03-24 |
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