CN108542831A - A kind of whitening and skin-protecting water and preparation method thereof with collaboration whitening effect - Google Patents
A kind of whitening and skin-protecting water and preparation method thereof with collaboration whitening effect Download PDFInfo
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
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- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
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- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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Abstract
The present invention provides a kind of whitening and skin-protecting water with collaboration whitening effect, which is characterized in that each component calculated comprising following mass percent：1 3% niacinamide；1 4% whitening compound；0.5 1.5% citrus bark extract；0.1 0.5% ursin；0.1 2% 1 methyl hydantoin, 2 acid imide；89 97% cosmetic matrix.The present invention also provides a kind of preparation methods for the whitening and skin-protecting water for having and cooperateing with whitening effect.It can be to avoid skin because the signal of some whitening node enhances the phenomenon that obtaining negative-feedback signal (melanin reduces, and needs mass production melanin) suddenly.Not only can act synergistically prominent whitening effect in several whitening key points, but also can be controlled on the node of entire whitening chain so that the generation of the reduction melanin of human skin system harmony is transmitted to reach whitening skin lightening result.
Description
Technical field
The present invention relates to cosmetic technical field, more particularly to a kind of whitening and skin-protecting water with collaboration whitening effect and its
Preparation method.
Background technology
East Asia women is from ancient times with Bai Weimei, in order to which whitening has used many methods.Such as milk is taken a shower.Even with very
Mostly virose substance, such as the lead mercury surface application of early stage, until eighties of last century is also used in someone.
Since modern age, many whitening agents have been selected in people's exploitation.Currently, one of the active matter of most effective skin whitening is
Quinhydrones, but quinhydrones molecular weight is small, destroys melanocyte, and may induce inflammation.So quinhydrones is most of in the world
Country is limited by stringent legislation, is prohibited to be used as components of cosmetics.
Rhododendrol was once the leading whitening active object of a Japanese famous cosmetics company.It is produced behind but excessively
The problem of whitening.Later the said firm apologizes in view of this problem to client.
Azelaic acid is a kind of aliphatic acid of naturally occurring medium chain.It is a kind of important skin-whitening agents, there is suppression
The effect of tyrosinase processed.But application when there is also some technologies and formula in terms of the problem of.First, azelaic acid must be
It is just effective when high concentration.Azelaic acid is insoluble at high concentrations, keeps the cosmetics quality of preparation poor, and especially very thick system is very
Difficulty is smeared out.Secondly, the fusing point of azelaic acid is higher, and ordinary circumstance is prepared more difficult.
L-AA and its derivative and licorice are all easy discoloration, and stability still has no small ask
Topic is also to require special attention when in use.
Some present illegal businessman add glucocorticoid for short-term profit in the cosmetics such as facial mask.It can be short
The tender effect compacted in vain is generated in phase, but is used for a long time and very serious consequence is generated to the skin of people.
With the development of modern science and technology, people are more and more deep to the understanding of colour of skin system.The depth of skin color
Regulated and controled by many factors, but the main content for still depending on melanin and distribution.Melanin is generated by melanocyte.It is black
Plain cell is one of important composition cell of skin, is in dendrite, and the melanin formed into the cell is transported by dendrite
Into corneocyte.It is with 1：36 ratios constitute an epidermis unit with keratinocyte, are present in basal layer of epidermis, black
Plain cell determines the skin color depth, while absorbable ultraviolet light by synthesis of melanin, makes damage of the body from ultraviolet light.
The specific forming process of melanin is as follows：When ultraviolet light irradiate skin when, horn cell be stimulated generate inflammation secretion inflammation because
Son and histamine etc., while DNA is damaged and generates free radicals.Melanocyte is broken up by stimulations such as inflammatory factor, free radicals
Accelerate.Internal tyrosinase activity increases, and tyrosine is converted into DOPA under the catalytic action of tyrosinase, is further converted to
DOPA quinone, DOPA quinone are finally translated into melanin through radical reaction.Melanosome is transmitted to horn cell through dendron.Most
The calmness of pigment in skin is caused eventually.
Since in the recent period, many companies develop some lightening compositions, are more some effect simple superposition in fact
Product, it is difficult to achieve the desired results.
How to develop efficient, safe and stablizing and with synergy whitening regime becomes present cosmetic industry
Where one difficult point.
Invention content
Insufficient existing for above-mentioned technology in order to make up, the first purpose of the invention is to provide one kind having collaboration whitening effect
The whitening and skin-protecting water of fruit.The whitening and skin-protecting water can absorb ultraviolet light, inhibit inflammatory factor, repair damaged dna, remove freely
Base inhibits tyrosinase, restores melanin, swallows melanin, and then achieve the purpose that whitening.The whitening and skin-protecting water both can be
Tyrosinase inhibits, emphasis acts in terms of melanin transfer, and can act synergistically in other respects, can both reach outstanding
Whitening effect again can be with equilibrium coordination without causing negative-feedback phenomenon.
Second object of the present invention is to provide a kind of preparation method of the whitening and skin-protecting water with collaboration whitening effect.
In order to realize above-mentioned two purpose, present invention employs technical solutions below：
A kind of whitening and skin-protecting water with collaboration whitening effect, includes each component of following mass percent meter：
Wherein, the ingredient of the whitening compound includes water, butanediol, ursin, citric acid, sodium sulfite, acetyl junket
Propylhomoserin, aaron's beard extract, peony root extractive, aminopropanol ascorbic acid phosphoric acid esters, radix scutellariae root extract, gluathione
Peptide, hydrolysis mirabalan；
Preferably, including each component of following mass percent meter：
Wherein, the ingredient of the whitening compound includes water, butanediol, ursin, citric acid, sodium sulfite, acetyl junket
Propylhomoserin, aaron's beard extract, peony root extractive, aminopropanol ascorbic acid phosphoric acid esters, radix scutellariae root extract, gluathione
Peptide, hydrolysis mirabalan.
Preferably, the cosmetic matrix includes moisturizer, chelating agent, thickener, emollient, skin condition
Agent, solubilizer, essence, preservative, water；
The constituent content of the cosmetic matrix, is calculated by mass percentage, and constitutes as follows：
Preferably, the constituent content of the cosmetic matrix, is calculated by mass percentage, constitute as follows：
Preferably, the Nicotinic Acid Content of the niacinamide is less than 100PPM.
Preferably, the constituent content of the whitening compound, is calculated by mass percentage, constitute as follows：
Water 46.3-50%, butanediol 40-50%, ursin 0.3-0.8%, citric acid 0.3-0.6%, sodium sulfite
0.4-0.6%, Acetyl Tyrosine 0.1-0.3%, aaron's beard extract 0.01-0.3%, peony root extractive 0.01-
0.2%, aminopropanol ascorbic acid phosphoric acid esters 0.001-0.1%, radix scutellariae root extract 0.01-0.1%, glutathione 0.001-
0.1%, hydrolysis mirabalan 0.01-0.6%.
Preferably, the citrus bark extract is extracted using carbon dioxide supercritical extraction technology, the citrus
The flavones content of bark extract is more than 2.5%.
Preferably, the ursin is the cosmetics-stage raw material that ursin content surpasses 98%.
Preferably, the 1- methyl hydantoins -2- acid imides, which are content, surpasses 98%.
A kind of preparation side of the whitening and skin-protecting water with collaboration whitening effect described in claim 1-9 any claims
Method includes the following steps：
S1, dispensing：It is equipped with the raw material components for including following mass percent：
The niacinamide of 1-3%；1-4% whitening compounds；The citrus bark extract of 0.5-1.5%；The black bearberry of 0.1-0.5%
Glycosides；1- methyl hydantoin -2- the acid imides of 0.1-2%；The cosmetic matrix of 89-97%；
Wherein, the ingredient of the whitening compound includes water, butanediol, ursin, citric acid, sodium sulfite, acetyl junket
Propylhomoserin, aaron's beard extract, peony root extractive, aminopropanol ascorbic acid phosphoric acid esters, radix scutellariae root extract, gluathione
Peptide, hydrolysis mirabalan；
The chelating agent of the moisturizer 0.01-2% of 1-30%；The thickener of 0.001-0.5%；The skin tune of 0.01-30%
Manage agent；The essence of 0.005-1%；Suitable preservative；The water of surplus；
S2, Jiang Shui, moisturizer, chelating agent, thickener are added production pot and are stirred, and are heated to 80-85 DEG C, disperse
Uniformly, as A phases；
S3, when A phase temperature is down to 40-45 DEG C, be added to skin conditioning agent, niacinamide, whitening compound, citrus to A
Bark extract, ursin, 1- methyl hydantoin -2- acid imides, essence and preservative are added in production pot, and homogeneous 1 minute is made
For B phases；
S4, B phases are continued to stir；When being cooled below 38 DEG C, stop stirring, after detection is qualified, discharging.
Compared with prior art, the beneficial effects of the invention are as follows：
By using above-mentioned technical proposal, can be obtained to avoid skin because the signal of some whitening node enhances suddenly
The phenomenon that negative-feedback signal (melanin reduces, and needs mass production melanin).Both it can be assisted in several whitening key points
Same-action protrudes whitening effect, and can be controlled on the node of entire whitening chain so that the reduction of human skin system harmony
The generation of melanin is transmitted to reach whitening skin lightening result.
Specific implementation mode
A part of specific embodiment is set forth below, and the present invention will be described, these examples are served only for making into one the present invention
The explanation of step is not used to limit the present invention, does not represent limiting the scope of the invention.Other people make according to the present invention
Some it is nonessential modification and adjustment still fall within protection scope of the present invention.Unless otherwise instructed, percentage (%) below
It is mass percentage.
A kind of whitening and skin-protecting water with collaboration whitening effect of the present invention, including following mass percent meter is each
Component：
Wherein, the ingredient of the whitening compound is water, butanediol, ursin, citric acid, sodium sulfite, acetyl junket ammonia
Acid, aaron's beard extract, peony root extractive, aminopropanol ascorbic acid phosphoric acid esters, radix scutellariae root extract, gluathione
Peptide, hydrolysis mirabalan；
Various test apparatuses and reagent are commercial goods, are that can buy to obtain by commercial sources；Wherein, niacinamide
It is less than the cosmetic material of 100PPM for Nicotinic Acid Content；The general flavone content of citrus bark extract is more than 2.5%；Ursin be containing
Amount is more than 98% cosmetics-stage raw material.
Niacinamide used by this whitening and skin-protecting water is high-purity raw, and Nicotinic Acid Content is less than 100PPM.It is inhibiting
Melanosome shifts, and effect protrudes in terms of accelerating damaged dna reparation.
In this whitening and skin-protecting water when niacinamide content is less than 1%, after tested, whole whitening effect weakens very much.When
When niacinamide content is more than 3%, tested through cell in vitro, cytotoxicity is too big.Therefore 1-3% is selected.
The whitening compound that this whitening and skin-protecting water uses is water, butanediol, ursin, citric acid, sodium sulfite, acetyl junket
Propylhomoserin, aaron's beard extract, peony root extractive, aminopropanol ascorbic acid phosphoric acid esters, radix scutellariae root extract, gluathione
Peptide, hydrolysis mirabalan.The ratio of wherein each component is about：Water 40-50%, butanediol 40-50%, ursin 0.3-0.8%,
Citric acid 0.3-0.6%, sodium sulfite 0.4-0.6%, Acetyl Tyrosine 0.1-0.3%, aaron's beard extract 0.01-
0.3%, peony root extractive 0.01-0.2%, aminopropanol ascorbic acid phosphoric acid esters 0.001-0.1%, radix scutellariae root extract
0.01-0.1%, glutathione 0.001-0.1%, hydrolysis mirabalan 0.01-0.6%.,
In this whitening compound：
Absorb ultraviolet light --- ursin, radix scutellariae root extract；
Inhibit inflammatory factor activity --- radix scutellariae root extract, peony root extractive；
Inhibit tyrosinase activity --- ursin；
The polymerization of melanin autoxidation and reduction melanin is inhibited to be formed --- aaron's beard extract, scutellariae,radix
Extract, aminopropanol ascorbic acid phosphoric acid esters；
Repair UV-induced DNA damage --- aaron's beard extract；
Promote synthesis brown-black element rather than eumelanin --- glutathione；
Tyrosinase --- Acetyl Tyrosine is competed with tyrosine；
Promote hyperplasia and cutin update --- aminopropanol ascorbic acid phosphoric acid esters, citric acid；
Melanin is inhibited to be annexed by horn cell --- hydrolysis mirabalan.
By the research and experimental analysis to above-mentioned mechanism, in this whitening and skin-protecting water, when this whitening compound dosage is low
When 1%, this whitening and skin-protecting water whitening effect unobvious.When this whitening compound dosage is higher than 4%, this whitening and skin-protecting water
Heat-resisting light fastness stability is deteriorated.Therefore select dosage for 1-4%.
Effect of the citrus bark extract in this whitening and skin-protecting water, which is collaboration other components, keeps skin brighter and cleaner bright.And its
General flavone amount and type are a standards of its quality.The citrus bark extract used in this whitening and skin-protecting water uses carbon dioxide
The orange peel extractive total flavone content of supercritical extraction technique, this technology extraction can be more than 2.5%, hence it is evident that compare other modes
The content of extraction wants high.And there is environmental-friendly, energy saving advantage.In the experiment of this whitening and skin-protecting water, citrus bark extract
Content when less than 0.2%, role is small, when its content be more than 1.5% when, this whitening and skin-protecting water is in illumination and 45
It is easy discoloration when DEG C heat-resisting, therefore selects 0.5-1.5%.
It is the cosmetics-stage raw material that content surpasses 98% that ursin is selected in whitening and skin-protecting water of the present invention, has and inhibits black
The ability of key enzyme-tyrosinase activity in plain generating process also has the effect of absorbing ultraviolet light.Since ursin is being tied
There is similitude with tyrosine on structure, therefore can be with tyrosine competitive binding junket ammonia during tyrosine synthesis of melanin
Sour enzyme, to reduce the effect of tyrosinase catalysis tyrosine synthesis of melanin.The content of this whitening and skin-protecting water ursin is less than
When 0.1%, risen whitening effect very little；When its content is more than 0.8%, this whitening and skin-protecting water easily reddens during storage
Color.Therefore selection 0.1-0.5%.
It is the cosmetics-stage original that content surpasses 98% that 1- methyl hydantoin -2- acid imides are selected in whitening and skin-protecting water of the present invention
Material is migrated to horn cell from melanocyte come the brilliant white colour of skin by reducing melanin.The ammonia of its structure and human skin
Base acid derivative-creatinine has the phase same sex, there is good skin permeability, the effect bringd into play.1- first in this whitening and skin-protecting water
When the imido contents of base hydantoins -2- are less than 0.1%, risen skin lightening result very little；When its content is more than 2%, this is beautiful
White surfactant is easy discoloration when illumination and 45 DEG C are heat-resisting.Therefore selection 0.1-2%.
Moisturizer in whitening and skin-protecting water of the present invention includes but not limited to glycerine, propylene glycol, 1,3-PD, butanediol,
Hexylene glycol, 1,2- pentanediol, pungent glycol, allantoin, sorbierite, glycine betaine and combinations thereof.The chelating agent includes but unlimited
In EDETATE SODIUM, tetra- sodium of EDTA, citric acid, sodium citrate and combinations thereof.
Thickener in whitening and skin-protecting water of the present invention includes but not limited to ammonium acryloyl taurate/VP copolymer,
Sodium Polyacrylate, acrylic acid (ester) analog copolymer sodium, hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers, poly- third
Olefin(e) acid ester -13, ammonium acryloyldime-thyltaurate/- 25 Methacrylate Crosspolymer of docosyl alcohol polyethers, acrylic acid hydroxyl second
Ester/sodium acryloyldimethyl taurate copolymers and combinations thereof.
Skin conditioning agent in whitening and skin-protecting water of the present invention includes but not limited to α-mannosan, Sodium Hyaluronate, PCA
Sodium, glycine betaine, polyquaternium -51, levulan, Fructus Hordei Germinatus oligose glucoside, hydrogenated starch hydrolysate, Chondrus crispus
(CHONDRUS CRISPUS) extract, chitosan, beta glucan, creatine etc..
Embodiment 1-3 and reference examples 1-5
Embodiment 1, embodiment 2, embodiment 3, the whitening and skin-protecting water with collaboration whitening effect, raw material components proportioning
As shown in table 1.
Whitening and skin-protecting water (the unit of 1 embodiment 1-3 of table, reference examples 1-5 and blank example：Quality %)
Wherein, the component of whitening compound is as shown in table 2 below.
The component of 2 whitening compound of table
| Ingredient names | Content (quality %) |
| Water | 48.9930 |
| Butanediol | 48.7511 |
| Ursin | 0.4750 |
| Citric acid | 0.4750 |
| Sodium sulfite | 0.4750 |
| Acetyl Tyrosine | 0.1425 |
| Aaron's beard extract | 0.1188 |
| Peony root extractive | 0.0855 |
| Aminopropanol ascorbic acid phosphoric acid esters | 0.04725 |
| Radix scutellariae root extract | 0.0428 |
| Glutathione | 0.0048 |
| Hydrolyze mirabalan | 0.3890 |
A kind of preparation method with the whitening and skin-protecting water for cooperateing with whitening effect of embodiment 1-3, includes the following steps：
S1, it is equipped with raw material components as shown in table 1；
S2, Jiang Shui, moisturizer, chelating agent, thickener are added production pot and are stirred, and are heated to 80-85 DEG C, disperse
Uniformly, as A phases；
S3, when A phase temperature is down to 40-45 DEG C, be added to skin conditioning agent, niacinamide, whitening compound, citrus to A
Bark extract, ursin, 1- methyl hydantoin -2- acid imides, essence and preservative are added in production pot, and homogeneous 1 minute is made
For B phases；
S4, B phases are continued to stir；When being cooled below 38 DEG C, stop stirring, after detection is qualified, discharging.
Compliance test result test example (whitening evaluation)
1, tester：80 people's healthy womens (25~45 years old) are divided into 8 groups, and every group is respectively 10 people；Every group uses formula of the same race
Product.
2, test zone：Face's (left face blank sample, right face reference examples sample or embodiment sample)；
3, it uses：Sooner or later twice daily, it persistently uses 4 weeks
4, test equipment：Delfin SkinColorCatch (Finland)
5, effectiveness indicator：Measure variation (the Δ L of colour brightness*), ITA degree, the present invention in L*It is worth (brightness), ITA degree (face
Color individual type angle), it is primarily used to index.
Equation (1)：ΔL*=[L*(reference examples or embodiment product carry out after testing 1 month)-L*(carry out on-test
Before)]-[L*(after blank product carries out experiment 1 month)-L*(before carrying out on-test)]
(2)：ITA degree (represents coloration entire change situation, ITA ° of value is bigger, and the colour of skin is more shallow.)
6, test effect is as shown in table 3 below：
Found out by the result of table 3, whitening and skin-protecting water of the present invention has by the synergistic effect between component than more significant
Whitening, the effect of bright color, the effect than single whitening composition becomes apparent from.
Embodiment 4 and reference examples 6-15
The whitening and skin-protecting water with collaboration whitening effect of embodiment 4, raw material components proportioning are as shown in table 4.
Whitening water (the unit of 4 embodiment 4 of table, reference examples 6-15 and blank example：Quality %)
Wherein, the component of whitening compound is as shown in table 5 below.
The component of 5 whitening compound of table
| Ingredient names | Content (weight %) |
| Water | 48.9930 |
| Butanediol | 48.7511 |
| Ursin | 0.4750 |
| Citric acid | 0.4750 |
| Sodium sulfite | 0.4750 |
| Acetyl Tyrosine | 0.1425 |
| Aaron's beard extract | 0.1188 |
| Peony root extractive | 0.0855 |
| Aminopropanol ascorbic acid phosphoric acid esters | 0.04725 |
| Radix scutellariae root extract | 0.0428 |
| Glutathione | 0.0048 |
| Hydrolyze mirabalan | 0.3890 |
A kind of preparation method with the whitening and skin-protecting water for cooperateing with whitening effect of embodiment 4, includes the following steps：
S1, it is equipped with raw material components as shown in table 1；
S2, Jiang Shui, moisturizer, chelating agent, thickener are added production pot and are stirred, and are heated to 80-85 DEG C, disperse
Uniformly, as A phases；
S3, when A phase temperature is down to 40-45 DEG C, be added to skin conditioning agent, niacinamide, whitening compound, citrus to A
Bark extract, ursin, 1- methyl hydantoin -2- acid imides, essence and preservative are added in production pot, and homogeneous 1 minute is made
For B phases；
S4, B phases are continued to stir；When being cooled below 38 DEG C, stop stirring, after detection is qualified, discharging.
Compliance test result test example (whitening evaluation)
1, tester：77 people's healthy womens (25~45 years old) are divided into 11 groups, and every group is respectively 7 people, and every group uses formula of the same race
Product.
2, test zone：Face's (left face blank sample, right face reference examples sample or embodiment sample)；
3, it uses：Sooner or later twice daily, it persistently uses 4 weeks
4, test equipment：Delfin SkinColorCatch (Finland)
5, effectiveness indicator：Measure the variation (Δ L*) of variation, the ITA degree of colour brightness, L* values (brightness) in the present invention,
ITA degree (color individual type angle), is primarily used to index.
Equation (1)：ΔL*=[L*(reference examples or embodiment product carry out after testing 1 month)-L*(carry out on-test
Before)]-[L*(after blank product carries out experiment 1 month)-L*(before carrying out on-test)]
(2)：ITA degree (represents coloration entire change situation, ITA ° of value is bigger, and the colour of skin is more shallow.)
| ITA ° of range | Skin color is classified |
| 55–90 | Very light are very shallow |
| 41–54 | Light is shallow |
| 28–40 | Intermediate is medium |
| 10–27 | Tanned is tanned |
| -30–9 | Brown brown |
| -90–-29 | - 29Dark is dark-coloured |
6, test effect is as shown in table 6 below：
Found out by the result of table 6, whitening and skin-protecting water of the present invention has by the synergistic effect between component than more significant
Whitening, the effect of bright color becomes apparent from than two kinds, three kinds or four kinds at the whitening effect of subassembly.
Security test
1, number is tested：Totally 30 people, male 3 people, 27 people of female；Minimal ages：24 years old, max age：45
Year；35.73 ± 7.15 years old aspiration inclusion criteria of average age.
2, test method：Embodiment 1-4 does patch test.Qualified spot is selected to try device, in enclosed type patch test method,
Tested material about 0.020~0.025mL is placed in spot examination device, external application medical adhesive tape is pasted on subject back, is gone after 24 hours
Except tested material, observation dermoreaction in 0.5,24,48 hour, is pressed after removing patch《Cosmetics safety technical specification》
Dermoreaction grade scale records its result in (version in 2015).
3, evaluation criteria such as the following table 7：
7 skin adverse reaction grade scale of table
The result of table 7 is shown：Human skin enclosed type patch test results are shown, in 30 people0Example occursIt is positiveReaction, root
According to《Cosmetics safety technical specification》Regulation in (version in 2015), the tested material is to this batch subjectIt will notCause skin bad
Reaction.
Stability test
1, stability test sample：3 product of embodiment.
2, test method：Inner quality standard (illumination 1 month, high/low temperature are tested 3 months), higher than national standard, professional standard.
3, test result is as follows table 8
The result of table 8 is shown：Whitening and skin-protecting water of the present invention has good stability.
The above described is only a preferred embodiment of the present invention, be not intended to limit the present invention in any form, therefore
It is every without departing from technical solution of the present invention content, simply repaiied to any made by above example according to the technical essence of the invention
Change, equivalent variations and modification, in the range of still falling within technical solution of the present invention.
Claims (10)
1. a kind of whitening and skin-protecting water with collaboration whitening effect, which is characterized in that include each group of following mass percent meter
Point：
Wherein, the ingredient of the whitening compound include water, butanediol, ursin, citric acid, sodium sulfite, Acetyl Tyrosine,
Aaron's beard extract, peony root extractive, aminopropanol ascorbic acid phosphoric acid esters, radix scutellariae root extract, glutathione, water
Solve mirabalan.
2. the whitening and skin-protecting water with collaboration whitening effect according to claim 1, which is characterized in that include following quality
The each component of percentages：
Wherein, the ingredient of the whitening compound include water, butanediol, ursin, citric acid, sodium sulfite, Acetyl Tyrosine,
Aaron's beard extract, peony root extractive, aminopropanol ascorbic acid phosphoric acid esters, radix scutellariae root extract, glutathione, water
Solve mirabalan.
3. the whitening and skin-protecting water with collaboration whitening effect according to claim 1 or 2, which is characterized in that the makeup
Product excipient matrix includes moisturizer, chelating agent, thickener, emollient, skin conditioning agent, solubilizer, essence, preservative, water；
The constituent content of the cosmetic matrix, is calculated by mass percentage, and constitutes as follows：
4. a kind of whitening and skin-protecting water with collaboration whitening effect according to claim 3, which is characterized in that the makeup
The constituent content of product excipient matrix, is calculated by mass percentage, and constitutes as follows：
5. the whitening and skin-protecting water with collaboration whitening effect according to claim 1 or 2, which is characterized in that the nicotinoyl
The Nicotinic Acid Content of amine is less than 100PPM.
6. the whitening and skin-protecting water with collaboration whitening effect according to claim 1 or 2, which is characterized in that the whitening
The constituent content of compound, is calculated by mass percentage, and constitutes as follows：
Water 46.3-50%, butanediol 40-50%, ursin 0.3-0.8%, citric acid 0.3-0.6%, sodium sulfite 0.4-
0.6%, Acetyl Tyrosine 0.1-0.3%, aaron's beard extract 0.01-0.3%, peony root extractive 0.01-0.2%,
Aminopropanol ascorbic acid phosphoric acid esters 0.001-0.1%, radix scutellariae root extract 0.01-0.1%, glutathione 0.001-0.1%,
Hydrolyze mirabalan 0.01-0.6%.
7. the whitening and skin-protecting water with collaboration whitening effect according to claim 1 or 2, it is characterised in that：The citrus
Bark extract is extracted using carbon dioxide supercritical extraction technology, and the flavones content of the citrus bark extract is more than
2.5%.
8. the whitening and skin-protecting water with collaboration whitening effect according to claim 1 or 2, it is characterised in that：The black bearberry
Glycosides is the cosmetics-stage raw material that ursin content surpasses 98%.
9. the whitening and skin-protecting water with collaboration whitening effect according to claim 1 or 2, it is characterised in that：The 1- first
Base hydantoins -2- acid imides are that content surpasses 98%.
10. a kind of preparation side of the whitening and skin-protecting water with collaboration whitening effect described in claim 1-9 any claims
Method, which is characterized in that include the following steps：
S1, dispensing：It is equipped with the raw material components for including following mass percent：
The niacinamide of 1-3%；1-4% whitening compounds；The citrus bark extract of 0.5-1.5%；The ursin of 0.1-0.5%；
1- methyl hydantoin -2- the acid imides of 0.1-2%；The cosmetic matrix of 89-97%；
Wherein, the ingredient of the whitening compound include water, butanediol, ursin, citric acid, sodium sulfite, Acetyl Tyrosine,
Aaron's beard extract, peony root extractive, aminopropanol ascorbic acid phosphoric acid esters, radix scutellariae root extract, glutathione, water
Solve mirabalan；
The skin condition of the moisturizer of 1-30%, the chelating agent of 0.01-2%, the thickener of 0.001-0.5%, 0.01-30%
Agent, the essence of 0.005-1%, suitable preservative, surplus water；
S2, Jiang Shui, moisturizer, chelating agent, thickener are added production pot and are stirred, and are heated to 80-85 DEG C, and dispersion is equal
It is even, as A phases；
S3, when A phase temperature is down to 40-45 DEG C, be added to skin conditioning agent, niacinamide, whitening compound, orange peel to A and carry
Object, ursin, 1- methyl hydantoin -2- acid imides, essence and preservative is taken to be added in production pot, homogeneous 1 minute, as B
Phase；
S4, B phases are continued to stir；When being cooled below 38 DEG C, stop stirring, after detection is qualified, discharging.
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| CN108852999A (en) * | 2018-09-28 | 2018-11-23 | 广东温和堂健康科学有限公司 | A kind of formula and technique of Xinhui citrus reticulata flower extract liquor production facial mask |
| CN109394561A (en) * | 2018-12-14 | 2019-03-01 | 完美（中国）有限公司 | Composition for removing yellow and whitening skin, application and preparation method thereof |
| CN110787086A (en) * | 2019-11-26 | 2020-02-14 | 广州市胜梅化妆品有限公司 | Composition for whitening skin and removing freckles and preparation method thereof |
| CN110917118A (en) * | 2020-01-02 | 2020-03-27 | 广州博美芬生物科技有限公司 | Mask for inhibiting melanin from refluxing and percutaneous absorption to balance microecology |
| CN112933013A (en) * | 2021-03-06 | 2021-06-11 | 广州中草世家化妆品有限公司 | Herbal whitening and skin-brightening composition rich in ginseng essence and preparation method thereof |
| CN113893197A (en) * | 2021-10-29 | 2022-01-07 | 湖北省麦诗特生物科技有限公司 | Skin whitening and anti-saccharification soluble beautifying microneedle patch composition and preparation method thereof |
| CN115068391A (en) * | 2022-08-05 | 2022-09-20 | 维怡美生物科技(广州)有限公司 | Whitening composition, and whitening essence and whitening lotion containing same |
| CN115386625A (en) * | 2022-08-18 | 2022-11-25 | 宁波赛缪斯生物科技有限公司 | Method for customizing skin care product based on light and dirt resistance genes and skin care product |
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| WO2017102589A1 (en) * | 2015-12-14 | 2017-06-22 | Dsm Ip Assets B.V. | Composition comprising niacinamide and alpha-arbutin for skin lightening |
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| CN108852999A (en) * | 2018-09-28 | 2018-11-23 | 广东温和堂健康科学有限公司 | A kind of formula and technique of Xinhui citrus reticulata flower extract liquor production facial mask |
| CN109394561A (en) * | 2018-12-14 | 2019-03-01 | 完美（中国）有限公司 | Composition for removing yellow and whitening skin, application and preparation method thereof |
| CN109394561B (en) * | 2018-12-14 | 2021-11-02 | 完美（中国）有限公司 | Composition for removing yellow and whitening skin, application and preparation method thereof |
| CN110787086A (en) * | 2019-11-26 | 2020-02-14 | 广州市胜梅化妆品有限公司 | Composition for whitening skin and removing freckles and preparation method thereof |
| CN110917118A (en) * | 2020-01-02 | 2020-03-27 | 广州博美芬生物科技有限公司 | Mask for inhibiting melanin from refluxing and percutaneous absorption to balance microecology |
| CN112933013A (en) * | 2021-03-06 | 2021-06-11 | 广州中草世家化妆品有限公司 | Herbal whitening and skin-brightening composition rich in ginseng essence and preparation method thereof |
| CN112933013B (en) * | 2021-03-06 | 2022-02-18 | 广州中草世家化妆品有限公司 | Herbal whitening and skin-brightening composition rich in ginseng essence and preparation method thereof |
| CN113893197A (en) * | 2021-10-29 | 2022-01-07 | 湖北省麦诗特生物科技有限公司 | Skin whitening and anti-saccharification soluble beautifying microneedle patch composition and preparation method thereof |
| CN113893197B (en) * | 2021-10-29 | 2024-01-30 | 湖北省麦诗特生物科技有限公司 | Skin whitening and anti-saccharification soluble beautifying microneedle patch composition and preparation method thereof |
| CN115068391A (en) * | 2022-08-05 | 2022-09-20 | 维怡美生物科技(广州)有限公司 | Whitening composition, and whitening essence and whitening lotion containing same |
| CN115068391B (en) * | 2022-08-05 | 2024-01-26 | 维怡美生物科技(广州)有限公司 | Whitening composition, whitening essence containing same and whitening water |
| CN115386625A (en) * | 2022-08-18 | 2022-11-25 | 宁波赛缪斯生物科技有限公司 | Method for customizing skin care product based on light and dirt resistance genes and skin care product |
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