JPS62138411A - Cosmetic for preventing skin from ageing - Google Patents

Abstract

PURPOSE:The titled cosmetic that contains, as active ingredients, gamma- linolenic acid, as a major ingredient, essence of Swertia japonica, ginseng essence, vitamin E orotate, placerta extract and other blood circulation promoter and/or cell-activator. CONSTITUTION:The titled cosmetic contains (A) 0.05-3wt% of gamma-linolenic acid and (B) ingredients having actions to promote blood circulation and/or to activate cells. As an ingedient B, at least one selected from essence of Swertia japonica, ginseng essence, vitamin D orotate, diisopropylamine dichloroacetate, gamma-aminobutyric acid, D-pantothenyl ether, D- pantothenylethyl alcohol, and placenta extract is cited. The ingredient B is combined with ingredient A, which is an essential fatty acid with high physiological activity to activate the skin function to prevent skins from wrinkling and simultaneously keep skins moist and of fine texture. Thus, the cosmetic can develop synergistically aging-prevention action in a short time and keep the action continuously.

Description

Detailed Description of the Invention (Industrial Application Field) The present invention is directed to a method for treating skin characterized by containing γ-lylunic acid as a main component and a component having a blood circulation promoting effect and/or a cell activating effect. Regarding anti-aging cosmetics. More specifically, the present invention relates to cosmetics for preventing skin aging that have excellent skin aging prevention effects (improving rough skin, several times more stratum corneum effect, increasing the turnover rate of the stratum corneum, reducing wrinkles, etc.).

(Prior Art) Aging skin loses its flexibility and elasticity, wrinkles increase, the skin becomes dry and rough without smoothness, and a phenomenon of exfoliation of keratin cells is observed.

Essential fatty acids, including linoleic acid and α-lylunic acid, are
It is not biosynthesized within the human body and must be ingested from the outside through food. It is known that a deficiency of this essential fatty acid causes skin desquamation, stunted growth, etc., and significantly accelerates skin aging.

(Problems to be Solved by the Invention) In view of the above-mentioned problems, the inventors of the present invention have carefully investigated aging skin histologically, morphologically, biochemically, and physiologically for many years. When r-'J-nolenic acid, which has the highest physiological activity among essential fatty acids, and a specific substance described below are used together in the base of a scrap cosmetic, the synergistic effect of both will result in excellent skin aging prevention. A fast-acting product that shows its effects (excellent for improving rough skin and keratin, lowering the collagen/elastin ratio of connective tissue to reduce wrinkles and speed up turnover rate) within a very short time of one month after starting use. The present invention has been completed by discovering that it is possible to obtain a cosmetic composition for preventing skin aging that is both effective and long-lasting.

(Means for Solving the Problems) That is, the present invention provides γ-lylunic acid, blood circulation promoting action and/or
or a component having a cell activating effect; 2. The present invention relates to a cosmetic for preventing skin aging characterized by the following.

In the present invention, the ingredients having a blood circulation promoting effect and/or a cell V, activating effect include Jasmine japonica extract, Korean ginseng extract, vitamin E orotate, diisopropylamine dichloroacetate, γ-aminobutyric acid, D-pantothenyl ethyl ether, D - pantothenyl ethyl alcohol,
Particularly preferred is at least one selected from the group consisting of placenta extract, but other substances such as aloe extract, vitamin E nicotinate, biotin, etc. are also applicable.

The r-lylunic acid used in the present invention is of the Mortier genus 5 (
JP 57-144986), Mucor genus (Lipid
s, 6. 584. It is one of the essential fatty acids that is known to be present in the cell membranes of microorganisms such as (1971), as well as in evening primrose oil, milk, etc., and can be obtained by conventional lipid extraction methods and hydrolysis methods. .

Among the above-mentioned specific blood circulation promoters or cell activators, there are no specific manufacturing methods for the natural product extracts such as Oriental japonica extract and Korean ginseng extract, but the outline of each manufacturing method is as follows. It is as follows.

[Production method of Aspergillus japonica extract]

Assembly (5wertia JapOniCa Mak
This is an extract obtained by digesting the dried and pulverized whole plant of Ino) in flowering stage in ethanol or aqueous ethanol and filtering it. In the Examples, an extract obtained by the following method was used.

50 y of crushed Aspergillus japonica was mixed with water-containing ethanol (ethanol 9
Qwt%) 250g/digested at a temperature of 40 to 50°C, filtered, and digested again in the same manner as the residue several times to obtain 1.51 of an extract. After concentrating this under reduced pressure, 100 g of purified water was added to the residue, and after aging for 1 week, the insoluble portion was filtered off and the obtained extract was concentrated under reduced pressure. Then, ethanol was added to the extract until the ethanol content of the extract was 4 Qwt%. 10 (1+/) of Aspergillus japonica extract was obtained.

[Production method of Korean carrot extract]

Panax ginseng (Panax ginseng C, A
This is an extract obtained by cold-soaking 5- to 6-year-old dried and crushed roots of A., Meyer) in ethanol or aqueous ethanol, and filtering the mixture. In the Examples, an extract obtained by the following method was used.

Fifty pieces of crushed Panax ginseng were cold soaked in 200 ml of aqueous ethanol (ethanol 9Qwt%) for one week, filtered, and the ethanol obtained from the extract was distilled off, and purified water was added to bring the ethanol content of the extract to 5Qwt%. After adjusting it so that it becomes
It was filtered to obtain 100 ml of Korean ginseng extract.

The amount of r-lylunic acid to be added to cosmetics is not particularly limited and can be selected from a wide range, but it is usually 0.01 to 10% by weight, preferably 0.05 to 1% by weight, based on the total weight of the composition.
It is 8% by weight.

The amount of the blood circulation promoter and/or cell activator to be blended into the cosmetic of the present invention is appropriately adjusted depending on its effect or the dosage form of the cosmetic, but it is usually as shown in Table 1 below. The amounts shown are suitable. The blending amount was based on the total weight of the cosmetic composition.

1.4')-/' Table 1 The cosmetic composition for preventing skin aging of the present invention comprises r-') phosphoric acid,
The above blood circulation promoter or cell activator is combined with cream,
It can be added directly to skin cosmetic bases such as emulsions and lotions, or it can be blended by dissolving these compounds in oil phase components, aqueous phase components, and solvents such as alcohol to emulsify, mix, disperse, and It is prepared by performing treatments such as dissolution and solubilization.

(Effect of the invention) The cosmetic for preventing skin aging of the present invention enhances skin functions,
It synergistically prevents skin wrinkles, makes the skin smooth and moisturized, and has an excellent anti-aging effect (improves rough skin, improves dead skin cells, and speeds up skin turnover). Moreover, it can produce remarkable effects, such as appearing in a short period of time and lasting for a long time.

(Example) Examples will be described below.

Note that % shown in Examples means % by weight.

Method for measuring turnover rate of stratum corneum described in Examples,
The test method for measuring the effect of improving rough skin and the test method for measuring the effect of improving keratin are as follows.

(1) Method for measuring the turnover rate of the stratum corneum. An ointment containing 5% of the fluorescent dye danzyl chloride in white petrolatum is made, and the ointment is applied to the skin of the subject's forearm for 24 hours, and then the stratum corneum is danzyl chloride is osmotic-bonded to.

Thereafter, the test sample was applied to the same area twice a day (morning and evening), and the fluorescence of danzyl chloride was examined every day.The number of days until the fluorescence disappeared was defined as the turnover rate of the skin stratum corneum. Note that the turnover rate of the normal skin stratum corneum is 14 to 16 days, but in aged skin it is 18 days.
It grows around the day. On the other hand, if the anti-aging effect appears, the time will be shortened to around 12 days.

(2) Test method for measuring the effect of improving rough skin The effect of continuous application for 4 weeks was investigated on 20 middle-aged and elderly subjects who had rough skin on their lower legs. Approximately 1 g of the cosmetic sample was applied to the test site of the test subject's left lower leg twice a day, and the condition of the skin before and after the start of the test was evaluated according to the scale shown in Table 2. No sample was applied to the right lower leg, which served as a control.

Table 2 Judgment criteria for skin dryness -: Normal ±: 1 Thorough dryness, no scaling +: Dryness, mild scaling ++: Excessive dryness, moderate scaling + 10+: Dryness, significant scaling Test site and control site before and after the test Compare the judgment results and if the skin dryness has improved by two or more levels (for example, + → -1
++→±) was considered "effective," one level of improvement was considered "slightly effective," and no change was considered "ineffective." There were no cases of skin dryness progressing during the test period.

(3) Test method for measuring the effect of improving keratin (increasing the anti-peeling properties of keratinocytes) Apply Scotch tape (Tiban Mending Tape) to the test area skin before and after the above-mentioned rough skin improvement measurement test, and peel it off. The condition of the corneocytes attached to the tape was examined in detail using a scanning electron microscope, and the skin corneocyte anti-exfoliation property was separated according to the criteria in Table 3, and the corneum improvement effect was determined. Peeling characteristic evaluation If5 semi-Table 3 shows that if the difference between the evaluation score of the test site and that of the control site after 4 weeks of continuous application is 2 or more points, it is "effective", if it is 1 point, it is "slightly effective", and 0. Points were considered "invalid".

The exfoliation properties of these corneocytes serve as an index for determining the structural properties of the stratum corneum, and in general, in dry skin and aging skin, the intercellular bonds are weak and the structure is dense. It has been confirmed that the index is high due to the low gender.

(4) Sensory effect panel test Samples were applied to the faces of 30 middle-aged (80-50 years old) female panelists twice a day for 4 months, and each panelist applied 1
The condition of the skin after one month and the end of the treatment was evaluated for ``wrinkle smoothing effect,'' ``effect on texture,'' and ``effect on moisturizing feeling.''

(ν Artificial color, white) Example 1 (Skin milk) Table 4 Each skin milk having the formulation shown in Table 4 above was prepared by a conventional method. Table 5 shows the results of wiping the skin anti-aging effects (improving effect on rough skin, improving effect on dead skin cells, turnover rate of stratum corneum) of each skin cream of Example 1 and Comparative Example 8. The test results for the anti-aging effect on the skin of Example 2 are shown in Table 6.

Table 5: Skin aging prevention effect of skin milk containing r-lylunic acid *Slightly effective does not include. The same applies to the descriptions in the table below.

Table 6: Skin anti-aging effect of skin milk without γ-phosphoric acid As is clear from the above results, the skin milk of the present invention containing r IJ phosphoric acid and the above-mentioned blood circulation promoter or cell activator. In (Example 1-1 to Example 1-8), the skin aging prevention effect (the effect of improving rough skin, the effect of improving Kadoha, and the effect of increasing the turnover rate of the stratum corneum),
It is synergistically improved and expressed.

On the other hand, r! The skin milk of Comparative Example 3 containing only J-phosphoric acid and the skin milk of Comparative Example 2 containing only the blood circulation promoter or cell activator (Comparative Examples 2-1 to 2-8) have no effect on skin aging. Prevention effect is low. In addition, the skin milk (skin milk base) of Comparative Example 1 that does not contain (combined) both γ-lylunic acid and the above-mentioned blood circulation promoter or cell activator has no skin aging prevention effect.

Next, we will show the results of practical tests.

(Hereinafter referred to as "Extras") Table 7: Results of a practical test of skin milk containing γ-lylunic acid (after 1 month) Table 8: Results of a practical test of skin milk containing IJ phosphoric acid (4 Table 9: Practical test results of skin milk without r-lylunic acid (after 1 month) Table 10: Practical test results of skin milk without r-lylunic acid (after 4 months) Above As is clear from the results, the skin milk of the present invention (Examples 1-1 to 1-8) containing r-Rirun alcohol and the above-mentioned blood circulation promoter or cell activator can reduce wrinkles. The spreading effect, the effect on texture, and the effect on moisturizing sensation all appear after one month of use, and the effect is remarkable, fast-acting, and long-lasting, and the various effects are outstanding.

In contrast, the skin milks of Comparative Example 8 containing only γ-lylunic acid and Comparative Example 2 (Comparative Examples 2-1 to 2-8) containing only the blood circulation promoter or cell activator mentioned above Both effects are relatively low and slow-acting. In addition, the above-mentioned effect was not observed in skin milk base (base) as a control product.

II □+’(+

Claims (2)

[Claims] (1) A cosmetic for preventing skin aging, characterized by containing γ-linolenic acid and a component having a blood circulation promoting effect and/or a cell activating effect. (2) Ingredients that have a blood circulation promoting effect and/or a cell activating effect include Jasmine japonica extract, Korean ginseng extract, vitamin E orotate, diisopropylamine dichloroacetate, γ-aminobutyric acid, D-pantothenylethyl ether, D-pantothenylethyl The cosmetic for preventing skin aging according to claim (1), which is at least one selected from the group consisting of alcohol and placenta extract.