CN108619033A - Whitening and skin-protecting essence and preparation method thereof with collaboration whitening effect - Google Patents
Whitening and skin-protecting essence and preparation method thereof with collaboration whitening effect Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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Abstract
The present invention discloses a kind of whitening and skin-protecting essence and preparation method thereof with collaboration whitening effect.The whitening and skin-protecting essence of the present invention includes niacinamide, whitening compound 1, whitening compound 2, citrus bark extract and ursin etc..The formula of whitening and skin-protecting essence of the present invention has selected raw material with synergy, can inhibit tyrosinase activity, and inhibits melanin transfer, energy bright color again, it can also jointly act synergistically in each node in whitening path simultaneously, be finally reached safety, effective and stable whitening effect.
Description
Technical field
The present invention relates to cosmetic technical fields, more particularly to a kind of whitening and skin-protecting essence with collaboration whitening effect
And preparation method thereof.
Background technology
East Asia women is from ancient times with Bai Weimei, in order to which whitening has used many methods.Such as milk is taken a shower.Even with very
Mostly virose substance, such as the lead mercury surface application of early stage, until eighties of last century is also used in someone.
With the development of modern science and technology, people are more and more deep to the understanding of colour of skin system.The depth of skin color
Regulated and controled by many factors, but the main content for still depending on melanin and distribution.Melanin is generated by melanocyte.It is black
Plain cell is one of important composition cell of skin, is in dendrite, and the melanin formed into the cell is transported by dendrite
Into corneocyte.It is constituted an epidermis unit with 1: 36 ratio and keratinocyte, is present in basal layer of epidermis, black
Plain cell determines the skin color depth, while absorbable ultraviolet light by synthesis of melanin, makes damage of the body from ultraviolet light.
The specific forming process of melanin is as follows：When ultraviolet light irradiate skin when, horn cell be stimulated generate inflammation secretion inflammation because
Son and histamine etc., while DNA is damaged and generates free radicals.Melanocyte is broken up by stimulations such as inflammatory factor, free radicals
Accelerate.Internal tyrosinase activity increases, and tyrosine is converted into DOPA under the catalytic action of tyrosinase, is further converted to
DOPA quinone, DOPA quinone are finally translated into melanin through radical reaction.Melanosome is transmitted to horn cell through dendron.Most
The calmness of pigment in skin is caused eventually.
Since modern age, many whitening agents have been selected in people's exploitation.Currently, one of the active matter of most effective skin whitening is
Quinhydrones, but quinhydrones molecular weight is small, destroys melanocyte, and may induce inflammation.So quinhydrones is most of in the world
Country is limited by stringent legislation, is prohibited to be used as components of cosmetics.Rhododendrol was once certain Japanese famous cosmetics company master
The whitening active object beaten, but the problem of producing excessive whitening below.
Azelaic acid is a kind of aliphatic acid of naturally occurring medium chain.It is a kind of important skin-whitening agents, there is suppression
The effect of tyrosinase processed.But application when there is also some technologies and formula in terms of the problem of.First, azelaic acid must be
It is just effective when high concentration.Azelaic acid is insoluble at high concentrations, keeps the cosmetics quality of preparation poor, and especially very thick system is very
Difficulty is smeared out.Secondly, the fusing point of azelaic acid is higher, and ordinary circumstance is prepared more difficult.
L-AA and its derivative and licorice are all easy discoloration, and stability still has no small ask
Topic is also to require special attention when in use.
Some present illegal businessman add glucocorticoid for short-term profit in the cosmetics such as facial mask.It can be short
The tender effect compacted in vain is generated in phase, but is used for a long time and very serious consequence is generated to the skin of people.
Also many companies develop some lightening compositions, are more the products of some effect simple superposition, it is difficult to
It achieves the desired results.How to develop efficient, safety and stabilization and becomes makeup conduct now with synergistic whitening regime
Where one difficult point of industry.
Invention content
To overcome above-mentioned technological deficiency, the present invention to provide a kind of whitening and skin-protecting essence with collaboration whitening effect.The U.S.
White facial treatment essence can absorb ultraviolet light, inhibit inflammatory factor, repair damaged dna, remove free radical, inhibit tyrosinase, also
Former melanin swallows melanin, and then achievees the purpose that whitening.The facial treatment essence both can be in tyrosinase inhibition, melanin
Emphasis effect in terms of transfer, and can acting synergistically in other respects, not only can reach whitening effect but also can equilibrium coordination without drawing
Play negative-feedback phenomenon.
To solve the above-mentioned problems, present invention employs technical solutions below：
The whitening and skin-protecting essence with collaboration whitening effect of the present invention, includes the raw material group of following weight
Point：
The wherein described whitening compound 1 includes water, butanediol, ursin, citric acid, sodium sulfite, Acetyl Tyrosine, grass
Certain kind of berries Herba Saxifragae extract, peony root extractive, aminopropanol ascorbic acid phosphoric acid esters, radix scutellariae root extract, glutathione, hydrolysis
Mirabalan；The whitening compound 2 includes water, glycerine, sucrose dilaurate, polysorbate -20, Semen Pisi sativi extract, benzene
Oxyethanol, pungent glycol, p- anisic acids, sorbic acid.In the whitening compound 1：Ursin, radix scutellariae root extract can absorb ultraviolet
Line；Radix scutellariae root extract, peony root extractive, which have, inhibits inflammatory factor activity；Ursin can inhibit tyrosinase activity；Grass
Certain kind of berries Herba Saxifragae extract, radix scutellariae root extract, aminopropanol ascorbic acid phosphoric acid esters inhibit melanin autoxidation polymerization
And it reduces melanin and is formed；Aaron's beard extract can repair UV-induced DNA damage；Glutathione can promote to synthesize
Brown-black element rather than eumelanin；Acetyl Tyrosine competes tyrosinase with tyrosine；Aminopropanol ascorbic acid phosphoric acid esters, lemon
Lemon acid promotes hyperplasia and cutin update；Hydrolysis mirabalan inhibits melanin to be annexed by horn cell.
By the research and experimental analysis to above-mentioned mechanism, in this whitening and skin-protecting essence, when the whitening compound 1 is used
When amount is less than 1%, the whitening and skin-protecting essence whitening effect unobvious.When 1 dosage of whitening compound is higher than 4%, this
The heat-resisting light fastness stability of whitening and skin-protecting essence is deteriorated, therefore selects dosage for 1-4 parts.
Sucrose dilaurate and the collaboration of pea (PISUM SATIVUM) extract in whitening compound 2 of the present invention
Effect can effectively inhibit melanosome maturation, act on B16 melanocytes, can substantially reduce the formation and reduction of melanin
The activity of tyrosinase.In this whitening and skin-protecting essence, when 2 dosage of whitening compound is less than 1%, whitening effect is not
Obviously.When 2 dosage of whitening compound is higher than 3%, the heat-resisting light fastness stability of the whitening and skin-protecting essence is deteriorated.Therefore
Select dosage for 1-3 parts.
Effect of the citrus bark extract in this whitening and skin-protecting essence, which is collaboration other components, keeps skin brighter and cleaner bright.And
Its general flavone amount and type are a standards of its quality.The citrus bark extract used in this whitening and skin-protecting essence uses dioxy
Change carbon supercritical extraction technique, the orange peel extractive total flavone content of this technology extraction can be more than 2.5%, hence it is evident that than other
The content that mode is extracted wants high, and has environmental-friendly, energy saving advantage.In the experiment of this whitening and skin-protecting essence, orange peel
For the content of extract when less than 0.2%, role is small, and when its content is more than 1.5%, this whitening and skin-protecting essence exists
Illumination and 45 DEG C it is heat-resisting when be easy discoloration, therefore select 0.5-1.5 parts.
It is the cosmetics-stage raw material that content surpasses 98% that ursin is selected in this whitening and skin-protecting essence, has and inhibits melanin
The ability of key enzyme-tyrosinase activity in generating process also has the effect of absorbing ultraviolet light.Since ursin is in structure
Upper and tyrosine has similitude, therefore can be with tyrosine competitive binding tyrosine during tyrosine synthesis of melanin
Enzyme, to reduce the effect of tyrosinase catalysis tyrosine synthesis of melanin.The content of this whitening and skin-protecting essence ursin is less than
When 0.1%, risen whitening effect very little；When its content is more than 0.8%, this whitening and skin-protecting essence is variable during storage
Red, therefore select 0.1-0.5 parts.
Further, the whitening and skin-protecting essence with collaboration whitening effect of the present invention, including following weight
Component：
Niacinamide used by this whitening and skin-protecting essence is high-purity raw, and Nicotinic Acid Content is less than 100PPM.It is pressing down
Melanosome transfer processed, effect protrudes in terms of accelerating damaged dna reparation.When niacinamide content is less than in this whitening and skin-protecting essence
When 1%, after tested, whole whitening effect weakens very much.When niacinamide content is more than 3%, tested through cell in vitro, cell
Toxicity is too big.Therefore 1-3 parts are selected.
Specifically, whitening compound 1 of the present invention includes the raw material components of following parts by weight：40-50 parts of water, fourth two
40-50 parts of alcohol, 0.3-0.8 parts of ursin, 0.3-0.6 parts of citric acid, 0.4-0.6 parts of sodium sulfite, Acetyl Tyrosine 0.1-
0.3 part, 0.01-0.30 parts of aaron's beard extract, 0.01-0.20 parts of peony root extractive, aminopropanol ascorbic acid phosphorus
0.001-0.100 parts of acid esters, 0.01-0.10 parts of radix scutellariae root extract, 0.001-0.100 parts of glutathione, hydrolysis mirabalan
0.01-0.60 parts.
Specifically, whitening compound 2 of the present invention includes the raw material components of following parts by weight：36.95-50.0 parts of water,
28-30 parts of glycerine, 20-22 parts of sucrose dilaurate, polysorbate -20 be 5-6 parts, 2-3 parts of Semen Pisi sativi extract, benzene oxygen
2-3 parts of ethyl alcohol, glycol 1-2 parts pungent, 0.3-0.5 parts of p- anisic acids, 0.2-0.3 parts of sorbic acid.
Preferably, the Nicotinic Acid Content of niacinamide of the present invention is less than 100PPM；The citrus bark extract uses dioxy
Change carbon supercritical extract, general flavone content >=2.5%；The ursin is the cosmetics-stage raw material that content is more than 98%.
Further, whitening and skin-protecting essence of the present invention further includes 60-98 parts of cosmetic matrix, the cosmetics
Include the raw material components of following parts by weight in excipient matrix formula：
Further, cosmetic matrix of the present invention includes the raw material components of following parts by weight：
Preferably, skin conditioning agent of the present invention can be selected from triethanolamine, α-mannosan, Sodium Hyaluronate, pyrroles
Alkanone carboxylic acid sodium, glycine betaine, polyquaternium -51, levulan, Fructus Hordei Germinatus oligose glucoside, hydrogenated starch hydrolysate, Chondrus crispus
One or more of (CHONDRUS CRISPUS) extract, chitosan, beta glucan, creatine combine.
Preferably, moisturizer of the present invention can be selected from glycerine, propylene glycol, 1,3-PD, butanediol, hexylene glycol, and 1,
2- pentanediols, pungent glycol, allantoin, sorbierite, the combination of one or more of glycine betaine, carbomer；The chelating agent
It can be selected from EDETATE SODIUM, tetra- sodium of EDTA, citric acid, the combination of one or more of sodium citrate；The thickener is optional
From ammonium acryloyl taurate/VP copolymer, Sodium Polyacrylate, acrylic acid (ester) analog copolymer sodium, hydroxy-ethyl acrylate/
Sodium acryloyldimethyl taurate copolymers, polyacrylate -13, ammonium acryloyldime-thyltaurate/- 25 first of docosyl alcohol polyethers
Base acrylate crosspolymers, hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers, xanthan gum, in carbomer
One or more kinds of combinations；The emollient can be selected from mineral oil, isohexadecane, shea butter, olive oil, poly dimethyl
Siloxanes, Parleam, caprylic/capric triglyceride, glycerine three (thylhexoic acid) ester, saualane, palm acid ethyl oneself
Ester, Nexbase 2004, Parleam, ring five dimethyl silicone polymer, one or more of cyclohexasiloxane group
It closes.
Another technical object of the present invention is to provide the preparation methods of above-mentioned whitening and skin-protecting essence, include the following steps：
1), each raw material component is weighed by formula：1-3 parts of niacinamide；Whitening compound 1 is 1-4 parts；Whitening compound 2 is
1-3 parts；0.5-1.5 parts of citrus bark extract；0.1-0.5 parts of ursin；1-40 parts of moisturizer；0.01-2.00 parts of chelating agent；
0.05-5.00 parts of thickener；0.1-30.0 parts of emollient；0.01-40.00 parts of skin conditioning agent；0.01-1.00 parts of essence；It is anti-
Rotten agent 0.01-1.00 parts；0.01-1.00 parts of solubilizer；Suitable quantity of water；
2) water phase pot, is added in water, moisturizer, chelating agent, thickener, stirring is heated to 80-85 DEG C, is uniformly dispersed, and makees
For A phases；
3), emollient is added in oil phase pot, 75-80 DEG C is heated to, stirs evenly, as B phases；
4), A phases and B phase materials are pumped into emulsification pot, homogeneous, stirring cooling is added when temperature is down to 40-45 DEG C
Skin conditioning agent, niacinamide, whitening compound 1, whitening compound 2, citrus bark extract, ursin, essence, solubilizer and anti-
Rotten agent, homogeneous；
5), continue to stir, be cooled below 38 DEG C, stop stirring, after detection is qualified, discharging.
Compared with prior art, the beneficial effects of the invention are as follows：
It is of the present invention that there is the whitening and skin-protecting essence formula of collaboration whitening effect can avoid skin because of some whitening node
Signal the phenomenon that enhancing obtains negative-feedback signal (melanin reduce, need mass production melanin) suddenly.It both can be several
Act synergistically prominent whitening effect in a whitening key point, and can be controlled on the node of entire whitening chain so that human body skin
Skin system is harmonious, and the generation for reducing melanin is transmitted, to achieve the effect that whitening skin lightening.
Specific implementation mode
Hereinafter, preferred embodiments of the present invention will be described, it should be understood that preferred embodiment described herein is only used
In the description and interpretation present invention, it is not intended to limit the present invention.Unless otherwise instructed, the unit of parts by weight below be kilogram or
Kilogram.
Embodiment 1-3
One, it is formulated
There is the whitening and skin-protecting essence of collaboration whitening effect, raw material components proportioning, control described in 1-3 of the embodiment of the present invention
Content of the example 1-5 raw material components with when blank example component proportion, as shown in table 1 below.
Whitening and skin-protecting essence (the unit of 1 embodiment 1-3 of table, reference examples 1-5 and blank example：Parts by weight)
The whitening and skin-protecting essence total formula weight of embodiment 1-3, reference examples 1-5 and blank example are 100 parts by weight.
Two, the preparation process of whitening and skin-protecting essence
The manufacture craft of whitening and skin-protecting essence is as follows：
1) by the deionized water input water phase pot of Examples 1 to 3 in table 1, carbomer, acryloyldimethyl ox sulphur is added
Sour ammonium/VP copolymers are stirred to complete swelling, are added and are used 1.3- butanediols, the pre-dispersed good xanthan gum of glycerine, hyaluronic acid, so
EDTA-2NA is added afterwards, allantoin is warming up to 85 DEG C, insulated and stirred 20 minutes, as A phases.
2) dimethyl silicone polymer, Parleam input oil phase pot are warming up to 80 DEG C, stirred evenly, as B phases.
3) material of A phases, B phases is pumped into emulsification pot, stirring homogeneous 3 minutes opens cooling water, is cooled to 65 DEG C, is added
Triethanolamine, stirring are cooled to 45 DEG C, and addition ursin, niacinamide, whitening compound 1, whitening compound 2, orange peel carry
Take object, essence, solubilizer, preservative；Stirring 20 minutes, is cooled to room temperature, discharges after inspection qualification.Reference examples 1-5 and blank
The preparation process of the whitening and skin-protecting essence of example can be according to the preparation process of embodiment 1-3.
The wherein described whitening compound 1, raw material components formula and content are as shown in table 2 below；The whitening compound 2,
Its raw material components formula and content are as shown in table 3 below.
The raw material components formula of whitening compound 1 described in 2 embodiment 1-3 of table
The raw material components formula of whitening compound 2 described in 3 embodiment 1-3 of table
| Ingredient names | Content (parts by weight) |
| Water | 41.5000 |
| Glycerine | 28.0000 |
| Sucrose dilaurate | 20.0000 |
| Polysorbate -20 | 5.0000 |
| Pea (PISUM SATIVUM) extract | 2.0000 |
| Phenoxyethanol | 2.0000 |
| Pungent glycol | 1.0000 |
| P- anisic acids | 0.3000 |
| Sorbic acid | 0.2000 |
Three, compliance test result test example (whitening evaluation)
1, tester：80 people's healthy womens (25~45 years old) are divided into 8 groups, and every group is respectively 10 people；Every group uses formula of the same race
Product.
2, test zone：Face's (left face blank sample, right face reference examples sample or embodiment sample)；
3, it uses：Sooner or later twice daily, it persistently uses 4 weeks
4, test equipment：DelfinSkinColorCatch (Finland)
5, effectiveness indicator：Measure variation (the Δ L of colour brightness*), ITA degree, the present invention in L*It is worth (brightness), ITA degree (face
Color individual type angle), it is primarily used to index.
Equation (1)：ΔL*=[L*(reference examples or embodiment product carry out after testing 1 month)-L*(carry out on-test
Before)]-[L*(after blank product carries out experiment 1 month)-L*(before carrying out on-test)]
(2)：ITA degree (represents coloration entire change situation, ITA ° of value is bigger, and the colour of skin is more shallow.)
4 ITA degree meanings of table
| ITA ° of range | Skin color is classified |
| 55-90 | Very light are very shallow |
| 41-54 | Light is shallow |
| 28-40 | Intermediate is medium |
| 10-27 | Tanned is tanned |
| -30-9 | Brown brown |
| -90--29 | - 29 Dark are dark-coloured |
5, test effect is as shown in table 5 below：
Effect table is tested in the whitening of table 5 embodiment 1-3 and reference examples 1-5
Found out by the result of table 5, the whitening and skin-protecting essence described in the embodiment of the present invention 1~4, by between raw material components
Synergistic effect, has the effect of more significant whitening, bright color, than the effect of single whitening composition relative to reference examples 1~5
Fruit becomes apparent from.
Embodiment 4
One, it is formulated
The whitening and skin-protecting essence with collaboration whitening effect described in the embodiment of the present invention 4, raw material components proportioning, control
Content of the example raw material components with when blank example, as shown in table 6 below.
Whitening and skin-protecting essence (the unit of 6 embodiment 4 of table, reference examples 6-15 and blank example：Parts by weight)
The whitening and skin-protecting essence total formula weight of embodiment 4, reference examples 6-15 and blank example is 100 parts by weight.
The manufacture craft of whitening and skin-protecting essence described in embodiment 4 is as follows：
1) deionized water is put into water phase pot, carbomer, ammonium acryloyl taurate/VP copolymer stirring is added
It to complete swelling, is added and uses 1.3- butanediols, the pre-dispersed good xanthan gum of glycerine, hyaluronic acid, EDTA-2NA, urine is then added
Bursin is warming up to 85 DEG C, insulated and stirred 20 minutes.
2) dimethyl silicone polymer, Parleam input oil phase pot are warming up to 80 DEG C.
3) water phase pot, oil phase pot material are pumped into emulsification pot, and stirring homogeneous 3 minutes opens cooling water, is cooled to 65 DEG C, adds
Enter triethanolamine, stirring is cooled to 45 DEG C, is added with ursin, niacinamide, whitening compound 1, whitening compound 2, orange peel
Extract, essence, solubilizer, preservative；Stirring 20 minutes, is cooled to room temperature, discharges after inspection qualification.Reference examples 6-15 and sky
The preparation process of the whitening and skin-protecting essence of white example can be according to the preparation process of embodiment 4.
Wherein whitening compound 1 described in embodiment 4, raw material components formula and the content such as table 7, table 8 of whitening compound 2
It is shown.
The raw material components formula of 7 whitening compound 1 of table
The raw material components formula of 8 whitening compound 2 of table
| Ingredient names | Content (parts by weight) |
| Water | 41.5000 |
| Glycerine | 28.0000 |
| Sucrose dilaurate | 20.0000 |
| Polysorbate -20 | 5.0000 |
| Pea (PISUMSATIVUM) extract | 2.0000 |
| Phenoxyethanol | 2.0000 |
| Pungent glycol | 1.0000 |
| P- anisic acids | 0.3000 |
| Sorbic acid | 0.2000 |
Three, compliance test result test example (whitening evaluation)
1, tester：77 people's healthy womens (25~45 years old) are divided into 11 groups, and every group is respectively 7 people, and every group uses formula of the same race
Product.
2, test zone：Face's (left face blank sample, right face reference examples sample or embodiment sample)；
3, it uses：Sooner or later twice daily, it persistently uses 4 weeks
4, test equipment：DelfinSkinColorCatch (Finland)
5, effectiveness indicator：Measure the variation (Δ L*) of variation, the ITA degree of colour brightness, L* values (brightness) in the present invention,
ITA degree (color individual type angle), is primarily used to index.
Equation (1)：ΔL*=[L*(reference examples or embodiment product carry out after testing 1 month)-L*(carry out on-test
Before)]-[L*(after blank product carries out experiment 1 month)-L*(before carrying out on-test)]
(2)：ITA degree (represents coloration entire change situation, ITA ° of value is bigger, and the colour of skin is more shallow.)
9 ITA degree explanations of table
| ITA ° of range | Skin color is classified |
| 55-90 | Verylight is very shallow |
| 41-54 | Light is shallow |
| 28-40 | Intermediate is medium |
| 10-27 | Tanned is tanned |
| -30-9 | Brown brown |
| -90--29 | - 29Dark is dark-coloured |
6, test effect is as shown in the following table 10：
The whitening of 10 embodiment 4 of table and reference examples 6-15 are testedEffect table
Found out by the result of table 10, whitening and skin-protecting essence described in the embodiment of the present invention 4, is made by the collaboration between component
With with more significant whitening, the effect of bright color is brighter at the whitening effect of subassembly than two kinds, three kinds or four kinds
It is aobvious.
Four, security test
1, number is tested：Totally 30 people, male 3 people, 27 people of female；Minimal ages：24 years old, max age： 45
Year；35.73 ± 7.15 years old aspiration inclusion criteria of average age.
2, test method：Embodiment 1-4 does patch test.Qualified spot is selected to try device, in enclosed type patch test method,
Tested material about 0.020~0.025mL is placed in spot examination device, external application medical adhesive tape is pasted on subject back, is gone after 24 hours
Except tested material, observation dermoreaction in 0.5,24,48 hour, is pressed after removing patch《Cosmetics safety technical specification》
Dermoreaction grade scale records its result in (version in 2015).
3, evaluation criteria such as the following table 11：
11 skin adverse reaction grade scale of table
The result of table 11 is shown：Human skin enclosed type patch test results are shown, in 30 people0Example occursIt is positiveReaction,
According to《Cosmetics safety technical specification》Regulation in (version in 2015), the tested material is to this batch subjectIt will notCause skin not
Good reaction.
Five, stability test
1, stability test sample：4 whitening and skin-protecting essence product of embodiment.
2, test method：Inner quality standard (illumination 1 month, high/low temperature are tested 3 months), higher than national standard, professional standard.
3, test result is as follows shown in table 12.
12 stability test result of table
By stability test, the result of the whitening and skin-protecting essence product of embodiment 4 is as shown in Table 12：Whitening shield of the present invention
Skin essence has good stability.In addition, by identical test method, the stability test knot of Examples 1 to 3 is measured
Fruit is qualification, it may have preferable stability.
The above described is only a preferred embodiment of the present invention, be not intended to limit the present invention in any form, therefore
It is every without departing from technical solution of the present invention content, simply repaiied to any made by above example according to the technical essence of the invention
Change, equivalent variations and modification, in the range of still falling within technical solution of the present invention.
Claims (10)
1. a kind of whitening and skin-protecting essence with collaboration whitening effect, which is characterized in that include each original of following weight
Expect component：
The wherein described whitening compound 1 includes water, butanediol, ursin, citric acid, sodium sulfite, Acetyl Tyrosine, strawberry tiger
Auricled Hedyotis Herb extract, peony root extractive, aminopropanol ascorbic acid phosphoric acid esters, radix scutellariae root extract, glutathione, hydrolysis cherry
Lee；The whitening compound 2 includes water, glycerine, sucrose dilaurate, polysorbate -20, Semen Pisi sativi extract, benzene oxygen second
Alcohol, pungent glycol, p- anisic acids, sorbic acid.
2. whitening and skin-protecting essence according to claim 1, which is characterized in that include each component of following weight：
3. whitening and skin-protecting essence according to claim 1, which is characterized in that the whitening compound 1 includes following weight
The raw material components of part：40-50 parts of water, 40-50 parts of butanediol, 0.3-0.8 parts of ursin, 0.3-0.6 parts of citric acid, sodium sulfite
0.4-0.6 parts, 0.1-0.3 parts of Acetyl Tyrosine, 0.01-0.30 parts of aaron's beard extract, peony root extractive 0.01-
0.20 part, 0.001-0.100 parts of aminopropanol ascorbic acid phosphoric acid esters, 0.01-0.10 parts of radix scutellariae root extract, glutathione
0.01-0.60 parts 0.001-0.100 parts, hydrolysis of mirabalan.
4. whitening and skin-protecting essence according to claim 1, which is characterized in that the whitening compound 2 includes following weight
The raw material components of part：36.95-50.0 parts of water, 28-30 parts of glycerine, 20-22 parts of sucrose dilaurate, polysorbate -20 are
5-6 parts, 2-3 parts of Semen Pisi sativi extract, 2-3 parts of Phenoxyethanol, glycol 1-2 parts pungent, 0.3-0.5 parts of p- anisic acids, sorbic acid 0.2-
0.3 part.
5. the whitening and skin-protecting essence according to any one of claim 1-4, which is characterized in that the niacin of the niacinamide
Content is less than 100PPM；The citrus bark extract uses carbon dioxide supercritical extraction, general flavone content >=2.5%；It is described
Ursin is the cosmetics-stage raw material that content is more than 98%.
6. whitening and skin-protecting essence according to claim 1, which is characterized in that the whitening and skin-protecting essence further includes cosmetics
60-98 parts of excipient matrix includes the raw material components of following parts by weight in the cosmetic matrix formulations：
7. whitening and skin-protecting essence according to claim 6, which is characterized in that the cosmetic matrix includes following heavy
Measure the raw material components of part：
8. the whitening and skin-protecting essence described according to claim 6 or 7, which is characterized in that the skin conditioning agent is selected from three ethyl alcohol
Amine, α-mannosan, Sodium Hyaluronate, pyrrolidone sodium carboxylate, glycine betaine, polyquaternium -51, levulan, Fructus Hordei Germinatus oligose Portugal
One or both of glucosides, hydrogenated starch hydrolysate, Chondrus crispus extract, chitosan, beta glucan, creatine
Combination of the above.
9. the whitening and skin-protecting essence described according to claim 6 or 7, which is characterized in that the moisturizer is selected from glycerine, and the third two
Alcohol, 1,3-PD, butanediol, hexylene glycol, 1,2- pentanediol, pungent glycol, allantoin, sorbierite, one kind in glycine betaine or
Two or more combinations；The chelating agent be selected from EDETATE SODIUM, tetra- sodium of EDTA, citric acid, one or both of sodium citrate with
Upper combination；The thickener is selected from ammonium acryloyl taurate/VP copolymer, and Sodium Polyacrylate, acrylic acid (ester) class is total
Polymers sodium, hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers, polyacrylate -13, acryloyldimethyl ox sulphur
Sour ammonium/- 25 Methacrylate Crosspolymer of docosyl alcohol polyethers, hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate are total
Polymers, xanthan gum, the combination of one or more of carbomer；The emollient is selected from mineral oil, isohexadecane, breast wood fruit
Oil, olive oil, dimethyl silicone polymer, caprylic/capric triglyceride, glycerine three (thylhexoic acid) ester, saualane, palmitic acid second
The own ester of base, Nexbase 2004, Parleam, ring five dimethyl silicone polymer, one or both of cyclohexasiloxane with
Upper combination.
10. a kind of preparation method of whitening and skin-protecting essence, which is characterized in that include the following steps：
1), each raw material component is weighed by formula：1-3 parts of niacinamide；Whitening compound 1 is 1-4 parts；Whitening compound 2 is 1-3
Part；0.5-1.5 parts of citrus bark extract；0.1-0.5 parts of ursin；1-40 parts of moisturizer；0.01-2.00 parts of chelating agent；Thickening
0.05-5.00 parts of agent；0.1-30.0 parts of emollient；0.01-40.00 parts of skin conditioning agent；0.01-1.00 parts of essence；Preservative
0.01-1.00 parts；0.01-1.00 parts of solubilizer, water；
2) water phase pot, is added in water, moisturizer, chelating agent, thickener, stirring is heated to 80-85 DEG C, is uniformly dispersed, as A
Phase；
3), emollient is added in oil phase pot, 75-80 DEG C is heated to, stirs evenly, as B phases；
4), A phases and B phase materials are pumped into emulsification pot, homogeneous, skin is added when temperature is down to 40-45 DEG C in stirring cooling
Conditioner, niacinamide, whitening compound 1, whitening compound 2, citrus bark extract, ursin, essence, solubilizer and anti-corrosion
Agent, homogeneous；
5), continue to stir, be cooled below 38 DEG C, stop stirring, after detection is qualified, discharging.
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