CN110960455A - Essence composition with whitening effect and preparation method and application thereof - Google Patents
Essence composition with whitening effect and preparation method and application thereof Download PDFInfo
- Publication number
- CN110960455A CN110960455A CN201911234243.0A CN201911234243A CN110960455A CN 110960455 A CN110960455 A CN 110960455A CN 201911234243 A CN201911234243 A CN 201911234243A CN 110960455 A CN110960455 A CN 110960455A
- Authority
- CN
- China
- Prior art keywords
- propylene glycol
- whitening effect
- essence composition
- methyl
- nicotinamide
- Prior art date
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- Pending
Links
- 230000002087 whitening effect Effects 0.000 title claims abstract description 49
- 239000000203 mixture Substances 0.000 title claims abstract description 45
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 133
- 241000207199 Citrus Species 0.000 claims abstract description 29
- 235000020971 citrus fruits Nutrition 0.000 claims abstract description 29
- OWBTYPJTUOEWEK-UHFFFAOYSA-N butane-2,3-diol Chemical compound CC(O)C(C)O OWBTYPJTUOEWEK-UHFFFAOYSA-N 0.000 claims abstract description 27
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 25
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 25
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 25
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 claims abstract description 24
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 claims abstract description 24
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 claims abstract description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000008367 deionised water Substances 0.000 claims abstract description 23
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 23
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 claims abstract description 17
- 239000003755 preservative agent Substances 0.000 claims abstract description 6
- 230000002335 preservative effect Effects 0.000 claims abstract description 6
- 229960004063 propylene glycol Drugs 0.000 claims description 51
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 44
- 230000001804 emulsifying effect Effects 0.000 claims description 35
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims description 34
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 23
- 229960005323 phenoxyethanol Drugs 0.000 claims description 23
- 238000003756 stirring Methods 0.000 claims description 23
- 235000005152 nicotinamide Nutrition 0.000 claims description 19
- 239000011570 nicotinamide Substances 0.000 claims description 19
- 229960003966 nicotinamide Drugs 0.000 claims description 19
- 238000005303 weighing Methods 0.000 claims description 18
- 238000010438 heat treatment Methods 0.000 claims description 16
- 238000001816 cooling Methods 0.000 claims description 15
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 14
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims description 14
- 229960002216 methylparaben Drugs 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 12
- NCZPCONIKBICGS-UHFFFAOYSA-N 3-(2-ethylhexoxy)propane-1,2-diol Chemical compound CCCCC(CC)COCC(O)CO NCZPCONIKBICGS-UHFFFAOYSA-N 0.000 claims description 11
- 229940100524 ethylhexylglycerin Drugs 0.000 claims description 11
- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 claims description 5
- 239000002131 composite material Substances 0.000 claims description 5
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims description 4
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 3
- BVTHRGZMQHOCOL-UHFFFAOYSA-N OCC(O)(C1(NC(=O)NCNC(=O)NC2(CO)NC(=O)NC2=O)NC(=O)NC1=O)CO Chemical compound OCC(O)(C1(NC(=O)NCNC(=O)NC2(CO)NC(=O)NC2=O)NC(=O)NC1=O)CO BVTHRGZMQHOCOL-UHFFFAOYSA-N 0.000 claims description 3
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 claims description 3
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 claims description 3
- 229960003415 propylparaben Drugs 0.000 claims description 3
- VMZJCIQOZYJFRB-UHFFFAOYSA-N 3-iodoprop-1-yn-1-ol Chemical compound OC#CCI VMZJCIQOZYJFRB-UHFFFAOYSA-N 0.000 claims description 2
- SKKTUOZKZKCGTB-UHFFFAOYSA-N butyl carbamate Chemical compound CCCCOC(N)=O SKKTUOZKZKCGTB-UHFFFAOYSA-N 0.000 claims description 2
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 claims description 2
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 claims description 2
- 230000002421 anti-septic effect Effects 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 abstract description 7
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 38
- 210000003491 skin Anatomy 0.000 description 34
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 21
- 238000012360 testing method Methods 0.000 description 14
- 230000000694 effects Effects 0.000 description 5
- 230000007794 irritation Effects 0.000 description 5
- 210000002510 keratinocyte Anatomy 0.000 description 5
- 206010040914 Skin reaction Diseases 0.000 description 4
- 238000005282 brightening Methods 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 239000001054 red pigment Substances 0.000 description 4
- 230000035483 skin reaction Effects 0.000 description 4
- 231100000430 skin reaction Toxicity 0.000 description 4
- 230000009102 absorption Effects 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 230000003020 moisturizing effect Effects 0.000 description 3
- 239000003973 paint Substances 0.000 description 3
- 230000019612 pigmentation Effects 0.000 description 3
- 230000008591 skin barrier function Effects 0.000 description 3
- 230000002195 synergetic effect Effects 0.000 description 3
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 2
- 230000008021 deposition Effects 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 210000002752 melanocyte Anatomy 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 229940099451 3-iodo-2-propynylbutylcarbamate Drugs 0.000 description 1
- WYVVKGNFXHOCQV-UHFFFAOYSA-N 3-iodoprop-2-yn-1-yl butylcarbamate Chemical compound CCCCNC(=O)OCC#CI WYVVKGNFXHOCQV-UHFFFAOYSA-N 0.000 description 1
- 208000020154 Acnes Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 102100028314 Filaggrin Human genes 0.000 description 1
- 101710088660 Filaggrin Proteins 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 1
- 102000003425 Tyrosinase Human genes 0.000 description 1
- 108060008724 Tyrosinase Proteins 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 210000001787 dendrite Anatomy 0.000 description 1
- 239000007933 dermal patch Substances 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 210000001723 extracellular space Anatomy 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 230000036074 healthy skin Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 230000036564 melanin content Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- GYCKQBWUSACYIF-UHFFFAOYSA-N o-hydroxybenzoic acid ethyl ester Natural products CCOC(=O)C1=CC=CC=C1O GYCKQBWUSACYIF-UHFFFAOYSA-N 0.000 description 1
- 210000001539 phagocyte Anatomy 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 238000009781 safety test method Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 230000036620 skin dryness Effects 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 231100000041 toxicology testing Toxicity 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to the technical field of cosmetics, in particular to an essence composition with a whitening effect, and a preparation method and application thereof, wherein the essence composition with the whitening effect comprises the following components in percentage by mass: 0.05-0.4% of sodium hyaluronate, 0.02-0.1% of EDTA-2 Na0.05-0.2% of dipotassium glycyrrhizinate, 1.0-10.0% of nicotinamide, 1.0-6.0% of propylene glycol, 1.0-5.0% of methyl propylene glycol, 0.5-1.5% of 1, 2-pentanediol, 1.0-5.0% of citrus peel extract, 0.1-1.2% of preservative and 70.6-95.28% of deionized water.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to an essence composition with a whitening effect and a preparation method and application thereof.
Background
The beauty-seeking heart of people in the modern society is more and more prominent, and the white and red skin is probably the pursuit of most of the Chinese people. The amount and distribution of melanin content in the epidermis are the main reasons for determining human skin color, melanin is produced by melanocytes, and the production and consumption processes of melanin mainly comprise the following ways: the tyrosine produces dopa under the catalysis of tyrosinase, and the dopa is further oxidized and polymerized to form melanin; a part of melanin is transferred to keratinocytes through dendrites, and the melanin migrates to the stratum corneum along with the keratinocytes and finally drops off along with the keratinocytes; another part of melanin migrates to the superficial dermis, is phagocytized and degraded by phagocytes, or is transported to the blood circulation to be decomposed. The production and consumption of melanin are normal physiological processes, and melanin can protect the skin to some extent. However, due to factors such as ultraviolet light, the secretion of melanin increases, resulting in pigmentation of the skin and a less aesthetic appearance of the skin. Meanwhile, unhealthy living habits and environmental pollution cause more and more problems of poor skin state, rough skin, dull and dull luster, pigmentation and the like. With the pursuit of people for reddish-white skin, safe and effective whitening skin care products become a trend, and the comprehensive and effective improvement of whitening and brightening skin color from inside to outside is a new development direction for the research and development of cosmetics.
Among many whitening ingredients, niacinamide is most frequently used, is relatively stable and mild, has a small molecular weight and can be effectively absorbed by cells, and studies have shown that the absorption rate of skin rises linearly with the addition amount when the content of niacinamide is less than 2%, and the absorption rate is slowed down when the addition amount exceeds 2.0%. At present, products with the addition amount of more than 10 percent of nicotinamide are available, and the high content of nicotinamide can bring better whitening effect, but the irritation of the product is enhanced. Niacinamide itself is very mild, but it is a highly irritating substance because of the small amount of niacin that is added during the production of niacinamide, and when it is accumulated to a certain amount, it will cause some irritation to the skin.
Disclosure of Invention
In view of the above, one of the purposes of the present invention is to provide an essence composition with whitening effect, which has mild formula and low irritation, and can uniformly brighten skin color, improve dull skin, make skin smooth and bright, and improve skin barrier, so as to avoid the disadvantages of the prior art.
One of the purposes of the invention is realized by the following technical scheme:
the essence composition with the whitening effect comprises the following components in percentage by mass: 0.05-0.4% of sodium hyaluronate, 0.02-0.1% of EDTA-2 Na0.05-0.2% of dipotassium glycyrrhizinate, 1.0-10.0% of nicotinamide, 1.0-6.0% of propylene glycol, 1.0-5.0% of methyl propylene glycol, 0.5-1.5% of 1, 2-pentanediol, 1.0-5.0% of citrus peel extract, 0.1-1.2% of preservative and 70.6-95.28% of deionized water.
Further, the propylene glycol is 1, 2-propylene glycol, and the mass ratio of the methyl propylene glycol to the 1, 2-propylene glycol is 1: 1 to 3.
Further, the preservative is selected from one or a combination of more than two of methyl hydroxybenzoate, propyl hydroxybenzoate, ethyl hydroxybenzoate, phenoxyethanol, ethylhexyl glycerol, bis (hydroxymethyl) imidazolidinyl urea and iodopropynyl alcohol butyl carbamate.
Further, the paint comprises the following components in percentage by mass: 0.2% of sodium hyaluronate, 0.05% of EDTA-2Na0, 0.1% of dipotassium glycyrrhizinate, 5.0% of nicotinamide, 0.12% of methylparaben, 3.0% of propylene glycol, 2.0% of methyl propylene glycol, 1.0% of 1, 2-pentanediol, 2.0% of citrus peel extract, 0.4% of phenoxyethanol, 0.4% of ethylhexylglycerin and 86.13% of deionized water.
Further, the paint comprises the following components in percentage by mass: 0.15% of sodium hyaluronate, 0.05% of EDTA-2Na0, 0.1% of dipotassium glycyrrhizinate, 4.0% of nicotinamide, 0.12% of methylparaben, 5.0% of propylene glycol, 4.0% of methyl propylene glycol, 1.0% of 1, 2-pentanediol, 3.0% of citrus peel extract, 0.4% of phenoxyethanol, 0.4% of ethylhexylglycerin and 82.18% of deionized water.
Further, the paint comprises the following components in percentage by mass: 0.3% of sodium hyaluronate, 0.05% of EDTA-2Na0, 0.2% of dipotassium glycyrrhizinate, 8.0% of nicotinamide, 0.12% of methylparaben, 6.0% of propylene glycol, 3.0% of methyl propylene glycol, 1.2% of 1, 2-pentanediol, 5.0% of citrus peel extract, 0.4% of phenoxyethanol, 0.4% of ethylhexylglycerin and 75.73% of deionized water.
The beneficial effects are as follows:
(1) due to the fact that the nicotinamide is added into the essence composition with the whitening effect, the exfoliating of melanocytes containing melanin can be accelerated, the migration of melanin to skin cuticle can be reduced, the deposition of melanin on the cuticle can be reduced, the problems of dull skin, color spots and the like can be solved, meanwhile, the nicotinamide has the effects of resisting aging, removing acnes, controlling oil and the like, and in order to ensure that the irritation of a formula is lower and a better whitening effect is achieved, the adding amount of the nicotinamide is controlled to be 1-10%;
(2) the sodium hyaluronate is added, so that the moisturizing and water-locking effects are improved, the skin dryness is prevented, and the barrier function of the skin is improved, so that the moisturizing and water-locking effects are better, and the experience feeling is better;
(3) because the citrus peel extract is added, the citrus peel extract contains plant flavonoid, can promote the structure of keratinocyte when acting on the horny layer of skin, enables the keratinocyte of the skin to be flat and have tension, reduces the intercellular space, enables the horny layer to be smooth and transparent, enhances the skin barrier, simultaneously can promote the metabolism of filaggrin, and promotes the generation of more Natural Moisturizing Factors (NMF);
(4) because the citrus peel extract and the nicotinamide have better whitening effect under the synergistic effect, the nicotinamide reduces the deposition of melanin in the horny layer, the citrus peel extract enables the horny layer to be flat and smooth, and the synergistic effect enables the skin to be whitened from inside to outside, the components of the formula have good synergistic effect, the effect of brightening the skin can be achieved from inside to outside, the skin is enabled to be in a healthy skin state, the formula components are mild, the irritation is low, and the citrus peel extract and the nicotinamide are suitable for skin with dark skin and pigmentation.
The second purpose of the invention is to provide a preparation method of the essence composition with the whitening effect, which is simple and can be used for conveniently and quickly preparing the essence composition with the whitening effect, and the defects in the prior art are avoided.
The second purpose of the invention is realized by the following technical scheme:
a preparation method of an essence composition with a whitening effect is characterized by comprising the following steps: the method comprises the following steps:
the method comprises the following steps: firstly, adding deionized water, EDTA-2Na, dipotassium glycyrrhizinate and nicotinamide in a formula ratio into an emulsifying pot, weighing sodium hyaluronate and a part of propylene glycol into a container, uniformly dispersing, and adding the uniformly dispersed mixture into the emulsifying pot for later use;
step two: weighing methyl hydroxybenzoate and the rest propylene glycol in a container, heating to completely dissolve methyl hydroxybenzoate, and adding into the emulsifying pot in the first step; stirring and heating to fully dissolve all components, and cooling for later use after keeping the temperature for a period of time;
step three: adding methyl propylene glycol, 1, 2-pentanediol and phenoxyethanol \ ethylhexyl glycerol into the first container, uniformly dispersing, adding into the emulsifying pot in the second step, and uniformly stirring for later use;
step four: and (4) adding the citrus peel extract into the emulsifying pot in the third step, uniformly stirring, and cooling to room temperature to obtain the essence with the whitening effect.
Further, in the first step, the propylene glycol is 1, 2-propylene glycol and accounts for 0.5-3% by mass, and in the second step, the propylene glycol is 1, 2-propylene glycol and accounts for 0.5-3% by mass.
Further, in the second step, the mixture is stirred and heated to 90-95 ℃, and the temperature is reduced to 40-50 ℃ after the heat is preserved for 25-30 minutes.
The beneficial effects are as follows: the steps of the essence composition with the whitening effect are simplified and convenient in the preparation process, and the prepared essence composition with the whitening effect has the advantages of uniformly brightening the skin color, improving the skin dullness, enabling the skin to be smooth and transparent and improving the skin barrier, so that the preparation method has the advantages of high preparation speed, low energy consumption, good stability and mature preparation technology.
Detailed Description
The invention is further described with reference to the following examples.
The essence composition with the whitening effect comprises the following components in percentage by mass: 0.05-0.4% of sodium hyaluronate, 0.02-0.1% of EDTA-2 Na0.05-0.2% of dipotassium glycyrrhizinate, 1.0-10.0% of nicotinamide, 1.0-6.0% of propylene glycol, 1.0-5.0% of methyl propylene glycol, 0.5-1.5% of 1, 2-pentanediol, 1.0-5.0% of citrus peel extract, 0.1-1.2% of preservative and 70.6-95.28% of deionized water.
In a preferred embodiment, the propylene glycol is 1, 2-propylene glycol, and the mass ratio of the methyl propylene glycol to the 1, 2-propylene glycol is 1: 1 to 3.
In a preferred embodiment, the preservative is selected from one or a combination of two or more of methylparaben, propylparaben, ethylparaben, phenoxyethanol, ethylhexylglycerin, bis (hydroxymethyl) imidazolidinyl urea, and iodopropynyl butylcarbamate.
In a preferred embodiment, the composition comprises the following components in percentage by mass: 0.2% of sodium hyaluronate, 0.05% of EDTA-2Na0, 0.1% of dipotassium glycyrrhizinate, 5.0% of nicotinamide, 0.12% of methylparaben, 3.0% of propylene glycol, 2.0% of methyl propylene glycol, 1.0% of 1, 2-pentanediol, 2.0% of citrus peel extract, 0.4% of phenoxyethanol, 0.4% of ethylhexylglycerin and 86.13% of deionized water.
In a preferred embodiment, the composition comprises the following components in percentage by mass: 0.15% of sodium hyaluronate, 0.05% of EDTA-2Na0, 0.1% of dipotassium glycyrrhizinate, 4.0% of nicotinamide, 0.12% of methylparaben, 5.0% of propylene glycol, 4.0% of methyl propylene glycol, 1.0% of 1, 2-pentanediol, 3.0% of citrus peel extract, 0.4% of phenoxyethanol, 0.4% of ethylhexylglycerin and 82.18% of deionized water.
In a preferred embodiment, the composition comprises the following components in percentage by mass: 0.3% of sodium hyaluronate, 0.05% of EDTA-2Na0, 0.2% of dipotassium glycyrrhizinate, 8.0% of nicotinamide, 0.12% of methylparaben, 6.0% of propylene glycol, 3.0% of methyl propylene glycol, 1.2% of 1, 2-pentanediol, 5.0% of citrus peel extract, 0.4% of phenoxyethanol, 0.4% of ethylhexylglycerin and 75.73% of deionized water.
The embodiment also provides a preparation method of the essence composition with the whitening effect, which comprises the following steps:
the method comprises the following steps: firstly, adding water, EDTA-2Na, dipotassium glycyrrhizinate and nicotinamide in a formula ratio into an emulsifying pot, weighing sodium hyaluronate and a part of propylene glycol into a container, uniformly dispersing, and adding the mixture into the emulsifying pot for later use;
step two: weighing methyl hydroxybenzoate and the rest propylene glycol in a container, heating to completely dissolve methyl hydroxybenzoate, and adding into the emulsifying pot in the first step; stirring and heating to fully dissolve all components, and cooling for later use after keeping the temperature for a period of time;
step three: adding methyl propylene glycol, 1, 2-pentanediol and phenoxyethanol \ ethylhexyl glycerol into the first container, uniformly dispersing, adding into the emulsifying pot in the second step, and uniformly stirring for later use;
step four: and (4) adding the citrus peel extract into the emulsifying pot in the third step, uniformly stirring, and cooling to room temperature to obtain the essence with the whitening effect.
In a preferred embodiment, in the first step, the propylene glycol is 1, 2-propylene glycol and is 0.5-3% by mass, and in the second step, the propylene glycol is 1, 2-propylene glycol and is 0.5-3% by mass
In a preferred embodiment, in the second step, the stirring and heating are carried out to 90-95 ℃, and the temperature is reduced to 40-50 ℃ after the heat preservation is carried out for 25-30 minutes.
The embodiment also provides application of the essence composition with the whitening effect, and the essence composition with the whitening effect is applied to skin care.
The invention will be further illustrated with reference to specific examples:
example 1
The essence composition with the whitening effect comprises the following components in parts by weight: 0.2% of sodium hyaluronate, 0.05% of EDTA-2Na0, 0.1% of dipotassium glycyrrhizinate, 5.0% of nicotinamide, 3.0% of 1, 2-propylene glycol, 2.0% of methyl propylene glycol, 1.0% of 1, 2-pentanediol, 2.0% of citrus peel extract, 0.12% of methylparaben, 0.4% of phenoxyethanol/ethylhexyl glycerol and 86.13% of deionized water.
The preparation method comprises the following steps:
the method comprises the following steps: firstly, 86.13% of deionized water, 0.05% of EDTA-2 Na0%, 0.1% of dipotassium glycyrrhizinate and 5.0% of nicotinamide are added into an emulsifying pot; weighing 0.2% of sodium hyaluronate and 1.0% of 1, 2-propylene glycol in a clean container, uniformly dispersing, and adding into an emulsifying pot;
step two: weighing 0.12% of methyl hydroxybenzoate and the rest 2.0% of 1, 2-propylene glycol in a clean container, heating to dissolve methyl hydroxybenzoate completely, and adding into an emulsifying pot; stirring and heating to 90-95 ℃ to fully dissolve all components, preserving heat for 25-30 minutes, and cooling to 45 ℃;
step three: weighing 2.0% of methyl propylene glycol, 1.0% of 1, 2-pentanediol and 0.4% of phenoxyethanol/ethylhexyl glycerol in a clean container, uniformly dispersing, adding into an emulsifying pot cooled to 45 ℃, and uniformly stirring;
step four: adding 2.0% of the citrus peel extract into an emulsifying pot at 45 ℃, uniformly stirring, and cooling to room temperature to obtain the essence composition with the whitening effect.
Example 2
The essence composition with the whitening effect comprises the following components in parts by weight: 0.15% of sodium hyaluronate, 0.05% of EDTA-2Na0, 0.1% of dipotassium glycyrrhizinate, 4.0% of nicotinamide, 5.0% of 1, 2-propylene glycol, 4.0% of methyl propylene glycol, 1.0% of 1, 2-pentanediol, 3.0% of citrus peel extract, 0.12% of methylparaben, 0.4% of phenoxyethanol/ethylhexyl glycerol and 82.18% of deionized water.
The preparation method comprises the following steps:
the method comprises the following steps: firstly, 82.18% of deionized water, 0.05% of EDTA-2Na0, 0.1% of dipotassium glycyrrhizinate and 4.0% of nicotinamide are added into an emulsifying pot; weighing 0.15% of sodium hyaluronate and 2.0% of 1, 2-propylene glycol in a clean container, uniformly dispersing, and adding into an emulsifying pot;
step two: weighing 0.12% of methyl hydroxybenzoate and the rest 3.0% of 1, 2-propylene glycol in a clean container, heating to dissolve methyl hydroxybenzoate completely, and adding into an emulsifying pot; stirring and heating to 90-95 ℃ to fully dissolve all components, preserving heat for 25-30 minutes, and cooling to 45 ℃;
step three: weighing 4.0% of methyl propylene glycol, 1.0% of 1, 2-pentanediol and 0.4% of phenoxyethanol/ethylhexyl glycerol in a clean container, uniformly dispersing, adding into an emulsifying pot cooled to 45 ℃, and uniformly stirring;
step four: adding 3.0% of the citrus peel extract into an emulsifying pot at 45 ℃, uniformly stirring, and cooling to room temperature to obtain the essence composition with the whitening effect.
Example 3
The essence composition with the whitening effect comprises the following components in parts by weight: the composite material comprises the following components in percentage by mass: 0.3% of sodium hyaluronate, 0.05% of EDTA-2Na0, 0.2% of dipotassium glycyrrhizinate, 8.0% of nicotinamide, 0.12% of methylparaben, 6.0% of propylene glycol, 3.0% of methyl propylene glycol, 1.2% of 1, 2-pentanediol, 5.0% of citrus peel extract, 0.4% of phenoxyethanol, 0.4% of ethylhexylglycerin and 75.73% of deionized water.
The preparation method comprises the following steps:
the method comprises the following steps: firstly, 77.63% of deionized water, 0.05% of EDTA-2 Na0%, 0.2% of dipotassium glycyrrhizinate and 8.0% of nicotinamide are added into an emulsifying pot; weighing 0.3 percent of sodium hyaluronate and 3.0 percent of 1, 2-propylene glycol into a clean container, uniformly dispersing, and adding into an emulsifying pot;
step two: weighing 0.12% of methyl hydroxybenzoate and the rest 3.0% of 1, 2-propylene glycol in a clean container, heating to dissolve methyl hydroxybenzoate completely, and adding into an emulsifying pot; stirring and heating to 90-95 ℃ to fully dissolve all components, preserving heat for 25-30 minutes, and cooling to 45 ℃;
step three: weighing 3.0% of methyl propylene glycol, 1.2% of 1, 2-pentanediol and 0.4% of phenoxyethanol/ethylhexyl glycerol in a clean container, uniformly dispersing, adding into an emulsifying pot cooled to 45 ℃, and uniformly stirring;
step four: adding 5.0% of the citrus peel extract into an emulsifying pot at 45 ℃, uniformly stirring, and cooling to room temperature to obtain the essence with the whitening effect.
Example 4
The essence composition with the whitening effect comprises the following components in parts by weight: 0.15% of sodium hyaluronate, 0.05% of EDTA-2Na0, 0.15% of dipotassium glycyrrhizinate, 6.0% of nicotinamide, 4.0% of 1, 2-propylene glycol, 3.0% of methyl propylene glycol, 1.0% of 1, 2-pentanediol, 4.0% of citrus peel extract, 0.12% of methylparaben, 0.4% of phenoxyethanol/ethylhexyl glycerol and 81.13% of deionized water.
The preparation method comprises the following steps:
the method comprises the following steps: firstly, 81.13% of deionized water, 0.05% of EDTA-2 Na0%, 0.15% of dipotassium glycyrrhizinate and 6.0% of nicotinamide are added into an emulsifying pot; weighing 0.15% of sodium hyaluronate and 2.0% of 1, 2-propylene glycol in a clean container, uniformly dispersing, and adding into an emulsifying pot;
step two: weighing 0.12% of methyl hydroxybenzoate and the rest 2.0% of 1, 2-propylene glycol in a clean container, heating to dissolve methyl hydroxybenzoate completely, and adding into an emulsifying pot; stirring and heating to 90-95 ℃ to fully dissolve all components, preserving heat for 25-30 minutes, and cooling to 45 ℃;
step three: weighing 3.0% of methyl propylene glycol, 1.0% of 1, 2-pentanediol and 0.4% of phenoxyethanol/ethylhexyl glycerol in a clean container, uniformly dispersing, adding into an emulsifying pot cooled to 45 ℃, and uniformly stirring;
step four: adding 4.0% of the citrus peel extract into an emulsifying pot at 45 ℃, uniformly stirring, and cooling to room temperature to obtain the essence with the whitening effect.
Examples of the experiments
Firstly, safety testing.
Subject: the age is 20-50 years for 30 people, half of men and women.
The experimental method comprises the following steps: examples 1 to 4 spot test of the essence composition having whitening effect prepared; selecting a qualified spot tester, placing about 0.02-0.025 ml of a tested object into the spot tester by a closed spot test method, externally applying a medical adhesive tape to the upper back of the tested object, removing the tested object after 24 hours, observing skin reactions 0.5, 24 and 48 hours after the spot is removed, and recording the results according to the skin reactions respectively standard in technical Specification for cosmetic safety (2015 edition).
And (4) experimental conclusion: the experimental evaluation criteria are shown in table 1 below:
TABLE 1 grading Standard of adverse skin reactions
As shown in Table 1, the results of the human skin patch test showed that no positive reaction occurred in the subjects. According to the regulation in technical specifications for cosmetic safety (2015 edition), the test substance does not cause adverse skin reactions to the batch of subjects, so the essence compositions with whitening efficacy in examples 1-4 meet the detection regulation.
Second, evaluation experiment of human body brightness
The experimental principle is as follows: the amount of melanin and hemoglobin is measured by using three different wavelength absorptions and reflections to determine the appearance of skin color.
Subject: example 1 was used as a test sample. Healthy volunteers aged 20-50 years without skin diseases and allergic history were selected as test subjects, the number of volunteers was 10, and 5 male and female were selected.
An experimental instrument: mexamter MX18 (manufacturer: CK Electronic GmH, Germany)
The experimental conditions are as follows: room temperature below 20 + -2 deg.C, Relative Humidity (RH) below 50 + -5%; the tested person enters the testing environment 30min before the test for quiet test, and the tested part is exposed 10min before the test.
The experimental method comprises the following steps: according to the test requirements, the appropriate areas of the bending areas of the left and right cheeks and the right arm forearm of the tested person are selected as the tested areas. Before the cosmetics are coated, a probe of Mexamter MX18 is vertically placed on the skin, and after the measured value is stabilized after 3-5 s, the values of melanin and haematochrome of the measured part are read. The melanin and red pigment values immediately after, 1 week, 2 weeks, 3 weeks, 4 weeks, 5 weeks, 6 weeks after application of the cosmetic were measured according to standard procedures, respectively; the dark reddish pigment of each test site was measured 5 times, and the average value was obtained.
And (4) experimental conclusion: the experimental results are shown in tables 2 to 3 below:
TABLE 2 melanin values at different times using test samples
TABLE 3 Red pigment values at various times using test samples
As can be seen from tables 2 and 3 above, the test shows the color of the skin in terms of the melanin and red pigment content of the skin, with the lighter the skin color, i.e., the whiter the less the melanin and red pigment content. As can be seen from the table, example 1 has a clear brightening effect.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention, and not for limiting the protection scope of the present invention, although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (10)
1. The essence composition with the whitening effect is characterized in that: the composite material comprises the following components in percentage by mass: 0.05-0.4% of sodium hyaluronate, 0.02-0.1% of EDTA-2 Na0.05-0.2% of dipotassium glycyrrhizinate, 1.0-10.0% of nicotinamide, 1.0-6.0% of propylene glycol, 1.0-5.0% of methyl propylene glycol, 0.5-1.5% of 1, 2-pentanediol, 1.0-5.0% of citrus peel extract, 0.1-1.2% of preservative and 70.6-95.28% of deionized water.
2. The essence composition with whitening effect according to claim 1, wherein: the propylene glycol is 1, 2-propylene glycol, and the mass ratio of the methyl propylene glycol to the 1, 2-propylene glycol is 1: 1 to 3.
3. The essence composition with whitening effect according to claim 1, wherein: the antiseptic is selected from one or more of methyl hydroxybenzoate, propyl hydroxybenzoate, ethylparaben, phenoxyethanol, ethylhexyl glycerol, bis (hydroxymethyl) imidazolidinyl urea, and iodopropynyl alcohol butyl carbamate.
4. The essence composition with whitening effect according to claim 3, wherein: the composite material comprises the following components in percentage by mass: 0.2% of sodium hyaluronate, 0.05% of EDTA-2Na0, 0.1% of dipotassium glycyrrhizinate, 5.0% of nicotinamide, 0.12% of methylparaben, 3.0% of propylene glycol, 2.0% of methyl propylene glycol, 1.0% of 1, 2-pentanediol, 2.0% of citrus peel extract, 0.4% of phenoxyethanol, 0.4% of ethylhexylglycerin and 86.13% of deionized water.
5. The essence composition with whitening effect according to claim 3, wherein: the composite material comprises the following components in percentage by mass: 0.15% of sodium hyaluronate, 0.05% of EDTA-2Na0, 0.1% of dipotassium glycyrrhizinate, 4.0% of nicotinamide, 0.12% of methylparaben, 5.0% of propylene glycol, 4.0% of methyl propylene glycol, 1.0% of 1, 2-pentanediol, 3.0% of citrus peel extract, 0.4% of phenoxyethanol, 0.4% of ethylhexylglycerin and 82.18% of deionized water.
6. The essence composition with whitening effect according to claim 3, wherein: the composite material comprises the following components in percentage by mass: 0.3% of sodium hyaluronate, 0.05% of EDTA-2Na0, 0.2% of dipotassium glycyrrhizinate, 8.0% of nicotinamide, 0.12% of methylparaben, 6.0% of propylene glycol, 3.0% of methyl propylene glycol, 1.2% of 1, 2-pentanediol, 5.0% of citrus peel extract, 0.4% of phenoxyethanol, 0.4% of ethylhexylglycerin and 75.73% of deionized water.
7. The method for preparing the essence composition with whitening effect according to any one of claims 4 to 6, wherein: the method comprises the following steps:
the method comprises the following steps: firstly, adding deionized water, EDTA-2Na, dipotassium glycyrrhizinate and nicotinamide in a formula ratio into an emulsifying pot, weighing sodium hyaluronate and a part of propylene glycol into a container, uniformly dispersing, and adding the uniformly dispersed mixture into the emulsifying pot for later use;
step two: weighing methyl hydroxybenzoate and the rest propylene glycol in a container, heating to completely dissolve methyl hydroxybenzoate, and adding into the emulsifying pot in the first step; stirring and heating to fully dissolve all components, and cooling for later use after keeping the temperature for a period of time;
step three: adding methyl propylene glycol, 1, 2-pentanediol and phenoxyethanol \ ethylhexyl glycerol into the first container, uniformly dispersing, adding into the emulsifying pot in the second step, and uniformly stirring for later use;
step four: and (4) adding the citrus peel extract into the emulsifying pot in the third step, uniformly stirring, and cooling to room temperature to obtain the essence with the whitening effect.
8. The preparation method of the essence composition with whitening effect according to claim 7 comprises the following steps: in the first step, the propylene glycol is 1, 2-propylene glycol and accounts for 0.5-3% by mass, and in the second step, the propylene glycol is 1, 2-propylene glycol and accounts for 0.5-3% by mass.
9. The preparation method of the essence composition with whitening effect according to claim 7 comprises the following steps: and in the second step, stirring and heating to 90-95 ℃, preserving heat for 25-30 minutes, and cooling to 40-50 ℃.
10. The use of the essence composition with whitening effect according to any one of claims 1 to 6 or the essence composition with whitening effect according to any one of claims 7 to 9, which is prepared by the method for preparing the essence composition with whitening effect, is characterized in that: the essence composition with the whitening effect is applied to skin care.
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| CN113559001A (en) * | 2021-05-07 | 2021-10-29 | 烟台仙瑟商贸有限公司 | Whitening essence composition and preparation method and application thereof |
| CN115444769A (en) * | 2022-09-01 | 2022-12-09 | 陕西华润实业公司 | Compound cosmetic preservative and preparation method and application thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112587455A (en) * | 2020-12-23 | 2021-04-02 | 重庆市中药研究院 | Plant composition and herbal whitening and freckle removing sleep mask gel |
| CN113559001A (en) * | 2021-05-07 | 2021-10-29 | 烟台仙瑟商贸有限公司 | Whitening essence composition and preparation method and application thereof |
| CN113559001B (en) * | 2021-05-07 | 2023-04-25 | 烟台仙瑟商贸有限公司 | Whitening essence composition and preparation method and application thereof |
| CN115444769A (en) * | 2022-09-01 | 2022-12-09 | 陕西华润实业公司 | Compound cosmetic preservative and preparation method and application thereof |
| CN115501128A (en) * | 2022-09-26 | 2022-12-23 | 陕西畅想制药有限公司 | Composition and essence emulsion for regulating, whitening and brightening skin |
| CN115501128B (en) * | 2022-09-26 | 2023-08-15 | 陕西畅想制药有限公司 | Composition for regulating skin, whitening and brightening skin and essence emulsion |
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