CN115501128A

CN115501128A - Composition and essence emulsion for regulating, whitening and brightening skin

Info

Publication number: CN115501128A
Application number: CN202211187356.1A
Authority: CN
Inventors: 畅通; 甄文超; 传雅萍; 王佳; 杨颖洁
Original assignee: Shaanxi Changxiang Pharmaceutical Co ltd
Current assignee: Shaanxi Changxiang Pharmaceutical Co ltd
Priority date: 2022-09-26
Filing date: 2022-09-26
Publication date: 2022-12-23
Anticipated expiration: 2042-09-26
Also published as: CN115501128B

Abstract

The invention discloses a composition and an essence emulsion for skin regulation, whitening and brightening, wherein the composition for skin regulation, whitening and brightening comprises the following components: a whitening composition, a first whitening composition and a second whitening composition; wherein the whitening composition comprises a polyol and a salicylic acid derivative; the first whitening composition comprises an amino acid derivative and water, wherein the amino acid derivative comprises at least one of 1-methylhydantoin-2-imide, caprylyl glycine and caprylyl salicylic acid; the second whitening composition includes niacinamide, arginine ferulate, and potassium methoxysalicylate. The invention aims to solve the problems that most of raw materials in the existing whitening products need high component consumption and strong irritation, and a large amount of relieving components are required to be added in a formula to neutralize the irritation of the whitening components.

Description

Composition and essence emulsion for regulating, whitening and brightening skin

Technical Field

The invention relates to the technical field of whitening, and particularly relates to a composition and essence emulsion for regulating, whitening and brightening skin.

Background

With the cosmetic industry focusing on the safety of cosmetics more and more, whitening cosmetics are classified as special cosmetics, but the skin care requirement of whitening cosmetics is one of the largest categories of enthusiasm of Asian women, the market requirement is high and is not reduced, and therefore, safety and whitening become an urgent port.

The research finds that melanin precipitation is caused by environmental changes, such as endocrine dyscrasia, metabolic disorder, disease injury, ultraviolet radiation, skin inflammation, imbalance of oxidation and oxidation resistance in vivo and the like. The shade of skin color still depends primarily on the melanin content and distribution. Melanin is produced by melanocytes. Melanocytes, one of the important constituent cells of the skin, are dendritic processes through which melanin formed within the cell is transported to the stratum corneum. It forms an epidermal unit with keratinocyte in a certain proportion, and exists in the basal layer of epidermis, and melanocyte determines the skin color depth by synthesizing melanin, and can absorb ultraviolet ray to protect the organism from being damaged by ultraviolet ray. The specific melanin formation process is as follows: when ultraviolet rays irradiate the skin, keratinocytes are stimulated to produce inflammatory factors, histamine, and the like, and at the same time, DNA is damaged and free radicals are generated. Melanocytes are stimulated by inflammatory factors, free radicals, etc. to differentiate and accelerate. The activity of internal tyrosinase is increased, tyrosine is converted into dopa under the catalytic action of tyrosinase, and further converted into dopaquinone, the dopaquinone is converted into melanosomes through free radical reaction, and the melanosomes are transferred to keratinocytes through dendrites, so that melanin pigmentation is caused.

Through market analysis, the whitening raw materials are not difficult to obtain with safe dosage and few non-irritants, and the well-known mechanisms of the whitening and freckle-removing raw materials are as follows: 1. inhibiting melanin gene expression, such as whitening peptide; 2. complexing copper ions, such as phytic acid, kojic acid derivatives, and the like; 3. inhibiting melanosome transfer to the stratum corneum, such as niacinamide; 4. inhibiting melanin production, such as lactic acid, sodium lactate, etc.; 5. accelerating tyrosinase degradation, such as linoleic acid and the like; 6. reductive and competitive tyrosinase activities such as phenethyl resorcinol, glabridin, etc.; 7. reducing melanin, such as vitamin C and its derivatives. In the manner described above. Most raw materials need high component consumption and strong irritation, and a large amount of relieving components are added to neutralize the irritation of the whitening components in the formula, so that the effect of the whitening components cannot be expressed visually.

Disclosure of Invention

The invention mainly aims to provide a composition and an essence emulsion for regulating, whitening and brightening skin, and aims to solve the problems that most of raw materials in the existing whitening products need high component dosage and strong irritation, and a large amount of relieving components need to be added in a formula to neutralize the irritation of the whitening components.

In order to achieve the above purpose, the invention provides a composition for skin conditioning, whitening and brightening, which comprises the following components: a whitening composition, a first whitening composition and a second whitening composition;

wherein the whitening composition comprises a polyol and a salicylic acid derivative;

the first whitening composition comprises amino acid derivatives and water, wherein the amino acid derivatives comprise at least one of 1-methylhydantoin-2-imide, caprylyl glycine and caprylyl salicylic acid;

the second whitening composition includes niacinamide, arginine ferulate, and potassium methoxysalicylate.

Optionally, the salicylic acid derivative comprises ethylene glycol salicylate;

the polyhydric alcohol includes any one of 1, 2-pentanediol, ethoxydiglycol, 1, 3-butanediol, and 1, 3-propanediol.

Alternatively, the polyol is 1, 2-pentanediol;

in the whitening composition, the concentration of the 1, 2-pentanediol is 1-25 g/mL, and the concentration of the glycol salicylate is 1-4.5 g/mL.

Optionally, in the whitening composition, the 1, 2-pentanediol is 1 to 30 parts and the ethylene glycol salicylate is 1 to 5 parts.

Optionally, the amino acid derivative is 1-methylhydantoin-2-imide, and the water comprises ultrapure water;

in the first whitening composition, 0.1 to 10 parts of 1-methylhydantoin-2-imide and 5 to 50 parts of ultrapure water are used.

Optionally, the composition for skin conditioning, whitening and brightening further comprises a pH regulator, and the pH regulator is 0.01-2 parts.

Optionally, the pH adjuster comprises at least one of sodium hydroxide, triethanolamine, arginine.

Optionally, in the second whitening composition, the nicotinamide is 1 to 5 parts, the arginine ferulate is 1 to 3 parts, and the methoxy potassium salicylate is 1 to 3 parts.

Optionally, the composition for skin conditioning, whitening and brightening further comprises 4-butyl resorcinol, undecylenoyl phenylalanine and potassium methoxysalicylate.

In addition, the invention also provides essence emulsion which is characterized by comprising the composition for regulating, whitening and brightening the skin, wherein the composition for regulating, whitening and brightening the skin comprises the following components: a whitening composition, a first whitening composition and a second whitening composition;

the first whitening composition comprises an amino acid derivative and water, wherein the amino acid derivative comprises at least one of 1-methylhydantoin-2-imide, caprylyl glycine and caprylyl salicylic acid;

In the technical scheme of the invention, based on modern theoretical research, theories such as free radical theory, DNA repair and the like are applied, factors influencing skin color and aging are comprehensively considered, and the factors are comprehensively considered from four directions of antioxidation, ultraviolet resistance, saccharification resistance and whitening, so that the skin aging and blackening caused by skin oxidation, ultraviolet ray damage, skin saccharification, melanin precipitation and the like are improved, the skin is in a good state, and the effects of delaying aging and whitening are realized, wherein the irritation degree is tested through a chick embryo experiment, an amino acid active whitening raw material, namely 1-methylhydantoin-2-imide, is screened out, and meanwhile, the amino acid active whitening raw material has double functions of inhibiting tyrosinase activity and inhibiting melanin corpuscle transfer, and the whitening effect is comparable to that of kojic acid; through analyzing the hydrolyzability of an amide structure, the salicylic acid derivative without a whitening pathway is designed to carry out a tyrosinase inhibition test according to different concentration gradients, and the tyrosinase inhibition rate can be synergized by comparing the two data.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the structures shown in the drawings without creative efforts.

Fig. 1 is a graph comparing the 0 th and 84 th days after the composition for skin conditioning, whitening and brightening, provided in example 1 of the present invention, was used;

FIG. 2 is a schematic diagram of the reaction formula of the state of adding glycol salicylate;

FIG. 3 is a schematic representation of the reaction formula of ethylene glycol salicylate and ethylene glycol salicylate bimolecular polyether;

FIG. 4 is a comparison of the experimental test procedures of chick embryo chorioallantoic membrane.

The implementation, functional features and advantages of the objects of the present invention will be further explained with reference to the accompanying drawings.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the technical solutions of the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially. In addition, the meaning of "and/or" appearing throughout includes three juxtapositions, exemplified by "A and/or B" including either A or B or both A and B. In addition, technical solutions between the various embodiments may be combined with each other, but must be based on the realization of the capability of a person skilled in the art, and when the technical solutions are contradictory or cannot be realized, such a combination should not be considered to exist, and is not within the protection scope of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Through market analysis, the whitening raw materials are not difficult to obtain with safe dosage and few non-irritants, and the well-known mechanisms of the whitening and freckle-removing raw materials are as follows: 1. inhibiting melanin gene expression, such as whitening peptide; 2. complexing copper ions, such as phytic acid, kojic acid derivatives, and the like; 3. inhibiting melanosome transfer to the stratum corneum, such as niacinamide; 4. inhibiting melanin production, such as lactic acid, sodium lactate, etc.; 5. accelerating tyrosinase degradation, such as linoleic acid and the like; 6. reductive and competitive tyrosinase activities, such as phenethyl resorcinol, glabridin, etc.; 7. reducing melanin such as vitamin C and its derivatives. In the manner described above. Most raw materials need high component consumption and strong irritation, and a large amount of relieving components are added to neutralize the irritation of the whitening components in the formula, so that the effect of the whitening components cannot be expressed visually.

In view of the above, the present invention provides a composition for skin conditioning, whitening and brightening, which comprises the following components: a whitening composition, a first whitening composition and a second whitening composition; wherein the whitening composition comprises a polyol and a salicylic acid derivative; the first whitening composition comprises an amino acid derivative and water, wherein the amino acid derivative comprises at least one of 1-methylhydantoin-2-imide, caprylyl glycine and caprylyl salicylic acid; the second whitening composition includes niacinamide, arginine ferulate, and potassium methoxysalicylate.

In the technical scheme of the invention, based on modern theoretical research, theories such as free radical theory, DNA repair and the like are applied, factors influencing skin color and aging are comprehensively considered, and the factors are comprehensively considered from four directions of antioxidation, ultraviolet resistance, saccharification resistance and whitening, so that the skin aging and blackening caused by skin oxidation, ultraviolet ray damage, skin saccharification, melanin precipitation and the like are improved, the skin is in a good state, and the effects of delaying aging and whitening are realized, wherein the irritation degree is tested through a chick embryo experiment, an amino acid active whitening raw material, namely 1-methylhydantoin-2-imide, is screened out, and meanwhile, the amino acid active whitening raw material has double functions of inhibiting tyrosinase activity and inhibiting melanin corpuscle transfer, and the whitening effect is comparable to that of kojic acid; through analyzing the hydrolyzability of an amide structure, the salicylic acid derivative without a whitening pathway is designed to carry out a tyrosinase inhibition test according to different concentration gradients, and the tyrosinase inhibition rate can be synergistically enhanced through data comparison.

It should be noted that the specific type of the salicylic acid derivative is not limited as long as it can increase the whitening effect, and in some embodiments, the salicylic acid derivative is ethylene glycol salicylate; the polyhydric alcohol may be 1, 2-pentanediol, may be ethoxydiglycol, may be 1, 3-butanediol, and may also be 1, 3-propanediol.

Specifically, 1-methylhydantoin-2-imide can undergo hydrolysis reaction under certain conditions, the cyclic structure of the 1-methylhydantoin-2-imide can be changed from cyclic to linear, the structure is the hydrolysis state of amino acid (the amino acid is a kind of ampholyte, and the pH value of the solution when the amino acid mainly exists in a dipolar ion form is called isoelectric point), and due to the introduction of uncontrollable factors, a certain amount of glycol salicylate needs to be added, and the amount of salicylic acid decomposed by the hydrolysis process in a certain concentration can promote the amount ratio of the cyclic structure to the linear amino acid structure, so that the glycol salicylate in a certain concentration can accelerate the conversion of the 1-methylhydantoin-2-imide molecules in the cyclic structure to linear, improve the isoelectric point effect of the 1-methylhydantoin-2-imide molecules, and play a role in whitening and enhancing effects. The research and test of the inventor show that in the whitening composition, the 1, 2-pentanediol accounts for 1 to 30 parts, and the ethylene glycol salicylate accounts for 1 to 5 parts.

The glycol salicylate is taken as a salicylic acid derivative, a pathway on the sun-proof surface of the glycol salicylate plays a role in whitening, but the hydrolysis states of the glycol salicylate in different states can be analyzed to obtain the following reversible reaction in the structures of pure oil and aqueous solution:

when the glycol salicylate is added, the glycol salicylate generates two ether structures (shown in figure 2) with molecular formulas through dehydration condensation reaction of hydroxyl of the glycol salicylate, and the water solubility of the oily component with the long-chain ether structure is increased, so that the possible hydrolysis state of the oily component is improved.

Further, glycol salicylate and glycol salicylate bimolecular polyether in aqueous solution can generate corresponding hydrolysis process under certain conditions, the process can have reaction (as shown in figure 3), and due to the alcohol solubility of glycol salicylate, the concentration gradient is set as follows: under the condition of setting the concentration of the 1-methylhydantoin-2-imide to be the same, the PI value of the solution after the solution passes the test as a whole can obviously show that the ionization balance in the solution is positively promoted along with the increase of the concentration of the glycol salicylate, so that the conclusion can be drawn that the glycol salicylate promotes the positive hydrolysis of the 1-methylhydantoin-2-imide.

Specifically, in this example, the polyol is 1, 2-pentanediol; in the whitening composition, the concentration of the 1, 2-pentanediol is 1-25 g/mL, and the concentration of the glycol salicylate is 1-4.5 g/mL.

Setting an experimental scheme based on the concentration range and the proportion: the PI value of the hydrolyzed linear amino acid is larger when the structure of the linear amino acid is more, and the PI value of the hydrolyzed linear amino acid is shown by measuring the PI values of the hydrolyzed linear amino acid with or without adding glycol salicylate under the same 1-methylhydantoin-2-imide state.

The experimental steps are as follows: by adding water and alcohol, the aim of completely dispersing is to replace dissolving and dispersing by other polyols, and the water and the alcohol are not dispersed and added into the application formula.

TABLE 1

From the above data it can be derived: the PI value of the 1-methylhydantoin-2-imide can be improved by a certain amount of glycol salicylate, the isoelectric point of the crystal is improved, and the positive promotion of the active ingredients is increased, so that the obtained glycol salicylate can be cooperated with the 1-methylhydantoin-2-imide to whiten and synergize.

In some embodiments, the 1-methylhydantoin-2-imide comprises 1-methylhydantoin-2-imide and the water comprises ultrapure water; in the first whitening composition, 0.1 to 10 parts of 1-methylhydantoin-2-imide and 5 to 50 parts of ultrapure water are used.

Based on the above two control characterization indexes of high dosage and strong irritation, the irritation is tested by a chick embryo experiment, and the amino acid active whitening raw material 1-methylhydantoin-2-imide is screened out, and meanwhile, the amino acid active whitening raw material has double functions of inhibiting tyrosinase activity and inhibiting melanosome transfer, and the whitening effect is comparable to that of kojic acid. By analyzing the hydrolyzability of the amide structure, the glycol salicylate without whitening pathway is designed to be used for human body efficacy test according to different concentration gradients, and the two can be compared by data to synergize the inhibition rate of the tyrosinase, please refer to table 1 and fig. 4.

Wherein, table 2 is the chick embryo chorioallantoic membrane experimental result, and table 3 is the scoring standard table.

TABLE 2 chick embryo chorioallantoic Membrane test results

TABLE 3 Scoring criteria

Scoring	Phenomenon(s)
		0 point (min)	No reaction at 3min and 30min
1 minute (1)	No reaction in 3min, and flocculent diffuse bleeding in 30min
		2 is divided into	Flocculent diffuse hemorrhage in 3min
3 points of	3min, a large amount of diffuse bleeding
		4 is divided into	3min, a large amount of diffuse bleeding accompanied by blood spots
5 points of	3min, a large amount of diffuse bleeding accompanied by large blood clots and blackening blood vessels

Based on that 1-methyl hydantoin-2-imide and glycol salicylate are in a certain component ratio, the composition can be used for a cutin peeling test, a comparison test is carried out by judging whether the glycol salicylate exists or not, the 1-methyl hydantoin-2-imide is recorded as A, the 1-methyl hydantoin-2-imide and the glycol salicylate composition are recorded as B, the composition is prepared according to the formula design method, 2 parts of 1-methyl hydantoin-2-imide are contained in the B, 2 parts of 1-methyl hydantoin-2-imide and 1 part of glycol salicylate are contained in the B, and the comparison test experiment is carried out, so that the glycol salicylate and the 1-methyl hydantoin-2-imide can cooperate with the tyrosinase inhibition rate, and have the whitening and synergistic functions.

Further, in some embodiments, tyrosinase inhibition was tested according to the above-mentioned groups a and B (i.e. the test objects were at the same concentrations as described above), specifically, during the actual testing, the following steps were performed:

s1: the test substances are respectively diluted into multi-concentration samples by using a disodium hydrogen phosphate-citric acid buffer solution.

S2: adding 0.5mL of tyrosinase solution into each of the sample tube (T) and the enzyme reaction tube (C), replacing the sample background (T0) and the solvent background (C0) with 0.5mL of disodium hydrogen phosphate-citric acid buffer solution respectively, mixing the sample and the tyrosinase sufficiently, and placing the mixture in a water bath at 37 ℃ for incubation for 10 minutes. And sequentially adding 2mL of levodopa solution into each tube, controlling the reaction time of each tube to be 5 minutes, transferring the reaction solution of each tube into a cuvette after the reaction is finished, and measuring the light absorption value at 475 nm.

The sample loading operation is shown in table 3:

TABLE 3 tyrosinase inhibition experiment sample application protocol

The inhibition results of the test substances of each group on tyrosinase were calculated according to formula 1, and the inhibition ratio (%) = [1 (T-T) ₀ )/(C-C ₀ )]X is 100%; wherein T is the light absorption value of the sample tube (i.e. the light absorption value of the solution after the reaction of the sample and tyrosinase), T ₀ Is the sample background light absorption value, C is the light absorption value of the enzyme reaction tube (i.e. the light absorption value of the solution of tyrosinase and dopa reaction when no sample is added), C ₀ Is the background light absorption value of the solvent.

According to the test result, the following results can be obtained: under the same tested concentration (2%), the tyrosinase inhibition rate (80.34%) of the 1-methylhydantoin-2-imide and ethylene glycol salicylate composition is obviously improved compared with that of the single 1-methylhydantoin-2-imide (60.24%).

Further, in some embodiments, the composition for skin conditioning, whitening and brightening further comprises a pH regulator, and the pH regulator is 0.01-2 parts. The pH adjuster is added for the purpose of stabilizing the formulation, and therefore, the pH adjuster can be selectively added according to the application or the situation.

Further, the type of the pH regulator is not limited, and is preferably a regulator commonly used for neutralization in daily life, specifically, sodium hydroxide solution, salicylic acid solution, citric acid, sodium citrate, a mixture of citric acid and sodium citrate, or triethanolamine.

In some embodiments, in the second whitening composition, the nicotinamide is 1 to 5 parts, the arginine ferulate is 1 to 3 parts, and the methoxy potassium salicylate is 1 to 3 parts.

Specifically, in some embodiments, the composition for skin conditioning, whitening and brightening further comprises 4-butyl resorcinol, undecylenoyl phenylalanine and a potassium salt of methoxysalicylic acid.

In addition, the invention also provides an essence emulsion which comprises the composition for regulating, whitening and brightening the skin.

The essence milk also comprises the following components: 1-10 parts of glycerin, 0.02 part of disodium EDTA, 0.5-5 parts of xanthan gum, 0.2-2 parts of sodium hyaluronate, 1-3 parts of ethylhexyl glycerin, 1-3 parts of 1,2 hexanediol and 5-20 parts of the composite composition for skin regulation and whitening and brightening (namely the composition for skin regulation and whitening and brightening provided by the invention).

The essence milk can be prepared according to the following method: mixing glycerol, EDTA disodium, xanthan gum, sodium hyaluronate, ethylhexyl glycerol, 1, 2-hexanediol and deionized water, stirring uniformly at 80 ℃, quickly homogenizing for 5min until uniform, and stirring while preserving heat; cooling to 50 deg.C, adding the above composite composition for regulating, whitening and brightening skin, mixing, stirring, and discharging to obtain essence milk.

The technical solutions of the present invention are further described in detail below with reference to specific examples and drawings, it should be understood that the following examples are merely illustrative of the present invention and are not intended to limit the present invention.

Example 1

The composition for regulating, whitening and brightening skin comprises the following components: 15 parts of 1, 2-pentanediol, 3 parts of ethylene glycol salicylate, 10 parts of ultrapure water, 5 parts of 1-methylhydantoin-2-imide, 0.12 part of pH regulator, 3 parts of nicotinamide, 0.5 part of arginine ferulate and 1 part of potassium methoxysalicylate.

The preparation method comprises the following steps:

(1) Dissolving 1-methylhydantoin-2-imide with 5 parts of ultrapure water, uniformly dispersing by ultrasonic, and marking as A solution after the 1-methylhydantoin-2-imide is completely dispersed into a transparent solution;

(2) Dispersing glycol salicylate into 1, 2-pentanediol, and recording as a solution B;

(3) Dissolving nicotinamide, arginine ferulate and potassium methoxysalicylate with the rest ultrapure water, and mixing with pH regulator to obtain solution C;

(4) Mixing the solution A and the solution C according to the clarity (the ratio is 10;

(5) Mixing glycerol, EDTA disodium, xanthan gum, sodium hyaluronate, ethylhexylglycerin, 1, 2-hexanediol and deionized water, stirring uniformly at 80 ℃, quickly homogenizing for 5min to be uniform, and stirring while keeping the temperature; cooling to 50 deg.C, adding the above composite composition for regulating, whitening and brightening skin, mixing, stirring, and discharging to obtain the essence milk.

Example 2

The preparation method comprises the following steps:

(4) Mixing the solution A, the solution B and the solution C according to clarity (the ratio is 10;

(5) Mixing glycerol, EDTA disodium, xanthan gum, sodium hyaluronate, ethylhexylglycerin, 1, 2-hexanediol and deionized water, stirring uniformly at 80 ℃, quickly homogenizing for 5min to be uniform, and stirring while keeping the temperature; cooling to 50 deg.C, adding the above composite composition for regulating, whitening and brightening skin, mixing, stirring, and discharging to obtain essence milk.

Example 3

The composition for regulating, whitening and brightening the skin comprises the following components: 15 parts of 1, 2-pentanediol, 3 parts of ethylene glycol salicylate, 10 parts of ultrapure water, 5 parts of 1-methylhydantoin-2-imide, 0.12 part of pH regulator, 3 parts of nicotinamide, 0.5 part of arginine ferulate and 1 part of potassium methoxysalicylate.

The preparation method comprises the following steps:

(4) Mixing the solution B and the solution C according to clarity (the ratio is 18: 9.62) to obtain a composition for regulating, whitening and brightening skin;

(5) Mixing glycerol, EDTA disodium, xanthan gum, sodium hyaluronate, ethylhexyl glycerol, 1, 2-hexanediol and deionized water, stirring uniformly at 80 ℃, quickly homogenizing for 5min until uniform, and stirring while preserving heat; cooling to 50 deg.C, adding the above composite composition for regulating, whitening and brightening skin, mixing, stirring, and discharging to obtain essence milk.

Example 4

The composition for regulating, whitening and brightening skin comprises the following components: 10 parts of 1, 2-pentanediol, 2 parts of ethylene glycol salicylate, 10 parts of ultrapure water, 5 parts of 1-methylhydantoin-2-imide, 0.09 part of pH regulator, 3 parts of nicotinamide, 0.5 part of arginine ferulate and 2 parts of potassium methoxysalicylate.

The preparation method comprises the following steps:

(1) Dissolving 1-methylhydantoin-2-imide with 5 parts of ultrapure water, uniformly dispersing by ultrasonic, and marking as a solution A after the 1-methylhydantoin-2-imide is completely dispersed into a transparent solution;

(4) Mixing the solution a, the solution B and the solution C according to the clarity (ratio 10;

Example 5

The preparation method comprises the following steps:

(4) Mixing the solution A and the solution B according to the clarity (the ratio is 10;

Performance test

An experimental instrument: skin physiological index tester MC760 (CK, germany), oil and fat tape (CK, germany), mercuric chloride buffer (CK, germany), and potassium chloride buffer (CK, germany).

Subject: 75 oil-sensitive skin groups which have statistical significance and have serious facial conformity with the red region are selected, skin problems such as pigmentation, desquamation and the like caused by inflammation can be obviously caused, and the consistency of the age and the sex is kept as much as possible by analyzing stripping data, analyzing tolerance values and analyzing the oil secretion and the pH value.

1. Repair test

Dividing the experimental subjects into 5 groups, wherein each group is 15 persons, measuring the facial characterization parameter value before use, using the essence milk provided by the embodiments 1 to 5 of the invention by five groups of testers, and testing the use condition after 84 days; wherein, the desquamation, erythema and dryness severity (mean ± SD) were evaluated by using a 10cm visual analog scale (reported in mm) with the desquamation, erythema and dryness as characterization parameters, and the specific test results are shown in table 4.

TABLE 4 test results

From table 4 it can be derived: the essential creams provided in examples 1 to 5 can improve the skin problems such as desquamation and dry erythema, and can be laterally illustrated, the combination can accelerate the renewal speed of the stratum corneum without negative stimulation to the skin, and the combination can be illustrated to have the effect of repairing the skin through erythema and dryness.

2. Index of oil secretion

(1) Measurement principle of oil secretion

The principle of sebum measurement is based on the principle of photometer of a special adhesive tape, and the extinction adhesive tape with the thickness of about 0.1mm absorbs grease on the skin of a human body and then becomes a semitransparent adhesive tape, so that the light transmittance of the semitransparent adhesive tape changes, and the more grease is absorbed, the greater the light transmittance is, and the content of the grease on the skin can be measured. The oil test method is recognized by the world scientific community as a simple indirect measurement result of sebaceous gland secretion, which can be used for distinguishing different skin types so as to accurately know the oil change caused by internal and external reasons (the oil secretion amount of dry skin people at the cheek is less than 70 mug/cm < 2 >, the oil secretion amount of normal skin people is 70-150 mug/cm < 2 >, and the oil secretion amount of oily skin is more than 150 mug/cm < 2 >).

(2) Method for measuring oil secretion amount

Before measurement and measurement of oil, the standard value is used for correction and the adhesive tape on the sebum test probe is ensured to be in an unused state, then the discussion is inserted into a corresponding sebum test hole on a host, a button on a handle is pressed, the probe is displayed and taken out on a computer screen, the screen counts down for seconds, and then the probe is advanced into the skin to be measured at an angle of 90 DEG with respect to the skin to be measuredAfter 30 seconds of measurement, the instrument will give an alarm to re-insert the probe into the host and gently press to obtain the sebum value in the unit of 0-350 mug/cm ² In the meantime.

3. Index of pH value

(1) principle of pH value test

The pH value measurement principle is that the probe tip formed by integrating the glass electrode and the reference electrode is composed of a glass semipermeable membrane which separates the internal buffer solution from the measured solution formed on the external skin surface, but hydrogen ions in the external measured solution can measure the corresponding pH value through the semipermeable membrane. (the pH range of the cheek dry skin population is 5.7-6.5, the normal skin population is 4.5-5.5, and the oily skin population is 3.5-4.3)

(2) Measuring method

The pH value is measured by calibrating the measuring instrument with a standard solution with the pH values of 7.0 and 4.0, a probe to be tested is firstly soaked in a potassium chloride buffer solution, a proper amount of distilled water is reserved on the probe which is cleaned by distilled water when the probe is prepared for testing, and the accuracy of a detection result is influenced and an error is caused by too much or too little water indicated by the probe. The operation procedure is started, then the probe and the skin to be measured form a 90-degree angle, the pressure for measuring is moderate, and excessive pressure can cause water loss between the probe and the skin, so that the accuracy of the result is influenced. After a few seconds the results of the measurements are displayed on a computer screen. The units of measurement are in the range of 0 to 12. (3)

(3) pH value measurement conditions

The measurement is carried out indoors, no direct sunlight exists, the room temperature is kept between 20 and 24 ℃, and the relative humidity of air is kept between 40 and 60 percent. Before measurement, a tested person is ordered, after the face is washed by warm water, the tested person does not use any cosmetics, waits for measurement in a waiting room and keeps the skin in a natural state for 2 hours. During measurement, a tested person takes a probe of the sitting position or horizontal position measuring instrument to vertically contact with the skin surface of a measuring position for a proper time to read and record a numerical value. Skin oil and pH value measurement area the area with high oil secretion and the other cheek area are averaged.

When the same test sample is used for testing, the fact that the oil content and the pH value of the face of the oil-sensitive skin test person group are obviously different and have statistical significance can be obtained as shown in table 5.

TABLE 5 test data

As can be seen from table 1, the essential milks prepared in examples 1 to 5 are consistently used, the amount of oil and fat is significantly reduced, and the pH precision range gradually tends to be stable, so that the composition for skin conditioning, whitening and brightening provided by the present invention can reduce the skin yellowing caused by oil and fat and the subsequent pigmentation problem caused by skin inflammation and the sensitivity problem caused by skin pH.

4. Follow-up return visit

The above 5 groups of subjects were followed up and interviewed to self-evaluate the overall facial status, and the results of the test are shown in table 6 and fig. 1 (where 0= weighted, 1= unchanged, 2= stable, and 3= improved) based on the average score of the total population with the decimal place remaining.

TABLE 6 test results

Days of use	Example 1	Example 2	Example 3	Example 4	Example 5
						7	1	2	1.3	1.8	1
15	2	2.3	2	2	1.8
						30	2.1	2.8	2	2.3	2
42	2.5	3	2.5	2.8	2.5
						56	3	3	3	3	3
64	3	3	3	3	3
						84	3	3	3	3	3

As can be seen from table 1 and fig. 1, the composition for skin conditioning, whitening and brightening provided by the present invention can improve the skin condition, and the skin condition of the tested person is significantly improved compared to that before use.

The above is only a preferred embodiment of the present invention, and it is not intended to limit the scope of the invention, and various modifications and changes will occur to those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention shall be included in the scope of the present invention.

Claims

1. The composition for regulating, whitening and brightening the skin is characterized by comprising the following components: a whitening composition, a first whitening composition and a second whitening composition;

2. The composition for skin conditioning, whitening and brightening of claim 1, wherein the salicylic acid derivative comprises glycol salicylate;

3. The composition for skin conditioning, whitening and lightening of claim 2, wherein the polyhydric alcohol is 1, 2-pentanediol;

4. The composition for skin conditioning, whitening and brightening according to claim 3, characterized in that 1 to 30 parts of the 1, 2-pentanediol and 1 to 5 parts of the ethylene glycol salicylate are contained in the whitening composition.

5. The composition for skin conditioning, whitening and brightening according to claim 1, characterized in that the amino acid derivative is 1-methylhydantoin-2-imide and the water comprises ultrapure water;

6. The composition for skin conditioning, whitening and brightening according to claim 1, further comprising a pH adjuster, wherein the pH adjuster is 0.01 to 2 parts.

7. The composition for skin conditioning, whitening and brightening of claim 6, wherein the pH adjusting agent comprises at least one of sodium hydroxide, triethanolamine, arginine.

8. The composition for skin conditioning, whitening and brightening according to claim 1, characterized in that in the second whitening composition, the niacinamide is 1 to 5 parts, the arginine ferulate is 1 to 3 parts, and the methoxy potassium salicylate is 1 to 3 parts.

9. The composition for skin conditioning, whitening and brightening of claim 1, further comprising 4-butylresorcinol, undecylenoylphenylalanine, and potassium methoxysalicylate.

10. An essence cream characterized by comprising the composition for skin conditioning, whitening and brightening according to any one of claims 1 to 9.