CN115317391B - Anti-wrinkle composition, anti-wrinkle essence cream applied by anti-wrinkle composition and preparation method of anti-wrinkle essence cream - Google Patents
Anti-wrinkle composition, anti-wrinkle essence cream applied by anti-wrinkle composition and preparation method of anti-wrinkle essence cream Download PDFInfo
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- CN115317391B CN115317391B CN202210889149.4A CN202210889149A CN115317391B CN 115317391 B CN115317391 B CN 115317391B CN 202210889149 A CN202210889149 A CN 202210889149A CN 115317391 B CN115317391 B CN 115317391B
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/606—Nucleosides; Nucleotides; Nucleic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
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- Birds (AREA)
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- Gerontology & Geriatric Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The application relates to the field of anti-wrinkle skin care products, and particularly discloses an anti-wrinkle composition, anti-wrinkle essence milk applied to the anti-wrinkle composition and a preparation method of the anti-wrinkle essence milk. An anti-wrinkle composition comprising the following separately stored raw materials in parts by weight: 0.1-5 parts of panthenol; 0.1-5 parts of a first moisture-retaining composition; 0.01-5 parts of a second moisturizing composition; 0.04-10 parts of adenosine; 0.1-20 parts of a first anti-wrinkle composition; 0.1-10 parts of a second anti-wrinkle composition; 0.1-10 parts of a third anti-wrinkle composition; 0.01-5 parts of carnosine; 0.001-0.5 parts of barley malt extract; and 0.01-5 parts of a third moisturizing composition. The anti-wrinkle composition can be used for cleansing milk, toner, essence cream, facial mask and the like, can promote and activate the metabolism of weak cells, activate the activity and metabolism of aging cells, improve the antioxidant in the aging cells, increase the generation of collagen precursors in the aging cells, and further enable skin barriers to be quickly self-repaired after being damaged, and has an excellent anti-wrinkle effect.
Description
Technical Field
The application relates to the field of anti-wrinkle skin care products, in particular to an anti-wrinkle composition, anti-wrinkle essence milk applied to the anti-wrinkle composition and a preparation method of the anti-wrinkle essence milk.
Background
Anti-wrinkle cosmetics, namely cosmetics capable of resisting aging and oxidation, are also called anti-aging skin care products, and anti-wrinkle and anti-oxidation active substances such as polypeptide, ceramide, grape seed extract, centella asiatica extract, hamamelis virginiana extract and the like are added into the cosmetics.
The Chinese patent application document with publication number of CN111643427A discloses an anti-aging composition, an anti-aging cosmetic and a preparation method thereof, wherein the anti-aging composition comprises the following components in parts by mass: 0.125-0.375 part of red ginseng extract, 1.0-4.0 parts of ginseng root water, 0.05-0.2 part of turmeric root extract, 0.02-0.2 part of cistanche extract, 0.02-0.2 part of dendrobium stem extract, 0.02-0.2 part of ganoderma sinensis extract, 0.02-0.2 part of poria cocos extract, 0.02-0.2 part of dogwood extract, 0.02-0.2 part of longleaf clover extract and 0.02-0.2 part of giant knotweed root extract. It has good oxidation resistance and cell activation effects, can prevent skin aging, effectively improve skin aging condition, and has excellent anti-aging effect.
In view of the above-mentioned related art, the inventors consider that in the above-mentioned patent application, the plant extracts are mixed to play a main role, but the skin is damaged by DNA caused by ultraviolet rays, it is difficult to quickly repair the skin barrier, the anti-wrinkle effect is difficult to stabilize and last, and the overall anti-wrinkle effect still remains to be improved.
Disclosure of Invention
In order to improve the anti-wrinkle effect of the anti-wrinkle composition, the application provides the anti-wrinkle composition, anti-wrinkle essence milk applied by the anti-wrinkle composition and a preparation method of the anti-wrinkle essence milk.
In a first aspect, the present application provides an anti-wrinkle composition, which adopts the following technical scheme:
an anti-wrinkle composition comprising the following separately stored raw materials in parts by weight:
0.1-5 parts of panthenol;
0.1-5 parts of a first moisture-retaining composition;
0.01-5 parts of a second moisturizing composition;
0.04-10 parts of adenosine;
0.1-20 parts of a first anti-wrinkle composition;
0.1-10 parts of a second anti-wrinkle composition;
0.1-10 parts of a third anti-wrinkle composition;
0.01-5 parts of carnosine;
0.001-0.5 parts of barley malt extract;
and 0.01-5 parts of a third moisturizing composition.
By adopting the above technical scheme, panthenol is a precursor of pantothenic acid (vitamin B5) which is a component of coenzyme A, the latter playing an important role for the co-acyl groups during fatty acid biosynthesis and gluconeogenesis. The increase of skin lipid synthesis will result in an improvement of the barrier, which in turn will lead to wound healing, in addition, panthenol will promote fibroblast proliferation and re-epithelialization of the epidermis, increase skin permeability, moisturize the stratum corneum, improve skin roughness and dryness, promote development of structural proteins required for the skin (such as collagen) and glutathione production in the skin, and this component can bind free radicals and peroxides, thereby reducing melanin formation, minimizing the appearance of pantothenic acid or vitamin B5 on the face, helping to produce fibroblasts in the middle layers of the skin (layers formed by wrinkles), and promote collagen, glycans and elastin production, making the skin appear young. Adenosine can enhance blood flow of skin, repair DNA damage caused by ultraviolet, complete skin barrier, increase collagen production, improve fine lines and wrinkles, reduce skin sensitivity, improve barrier function of epidermis, and improve skin darkness. Carnosine has effects and actions of maintaining normal metabolism of skin, accelerating excretion of metabolites from skin, homogenizing skin complexion, and improving self-resistance and self-healing force of skin. Meanwhile, the panthenol, the adenosine and the carnosine can play a good role in compounding and synergism, promote and activate the metabolism of the weak cells, activate the activity and metabolism of the aging cells, improve the antioxidants in the aging cells, increase the generation of collagen precursors in the aging cells, and further enable the skin barrier to be quickly self-repaired after being damaged, thereby playing an excellent anti-wrinkle effect.
Preferably, the anti-wrinkle composition comprises the following raw materials, stored separately in parts by weight:
0.2 parts of panthenol;
1 part of a first moisture-retaining composition;
0.5 parts of a second moisturizing composition;
0.3 parts of adenosine;
2 parts of a first anti-wrinkle composition;
1 part of a second anti-wrinkle composition;
1 part of a third anti-wrinkle composition;
0.05 parts of carnosine;
0.06 parts of barley malt extract;
and 0.3 parts of a third moisturizing composition.
By adopting the technical scheme, the anti-wrinkle composition obtained by preferable proportion can play an excellent anti-wrinkle effect in the application process.
Preferably, the first moisture-retaining composition comprises at least the following raw materials: saccharide isomers, water, citric acid and sodium citrate.
By adopting the technical scheme, saccharide isomers can be combined with lysine (free-amino) in keratin, and moisture is preserved deeply; the gene expression level of the filaggrin and the hyaluronic acid synthetase 3 can be adjusted upwards, the skin water retention capacity can be improved, the pocket nail protein gene expression level can be improved, the function of keratinization envelope is affected, the acid sphingomyelinase gene expression level can be improved, and the synthesis of ceramide can be stimulated. The citric acid and the sodium citrate are mainly used for regulating the pH value of cosmetics, can resist oxidation and corrosion, promote the synthesis of NMF (natural moisturizing factor) and hyaluronic acid, improve the skin moisturizing ability and improve the skin natural moisturizing ability.
Preferably, the second moisturizing composition comprises at least the following raw materials: water, honey extract and 1, 3-propanediol.
By adopting the technical scheme, the honey extract contains gluconic acid, improves the cathepsin in organisms, has the effects of nourishing, preserving moisture and softening skin, can help trace elements to be absorbed, and improves the effect of anti-wrinkle active ingredients on the skin.
Preferably, the third moisturizing composition comprises at least the following raw materials: butanediol, 1, 2-hexanediol, bacillus/soybean fermentation product extract, folic acid and sodium hyaluronate.
By adopting the technical scheme, folic acid can promote metabolism of protein in human body, and can play roles of resisting sensitization, preserving moisture and promoting cell growth when being used on skin. The sodium hyaluronate can permeate into epidermis and dermis layers, so that the skin can be moisturized. Bacillus/soybean fermentation product extract is a good humectant and skin conditioner.
Preferably, the first anti-wrinkle composition comprises at least the following raw materials: palmitoyl pentapeptide-4, water, glycerol, butylene glycol, carbomer, sodium lactate, and polysorbate-20. By adopting the technical scheme, the first anti-wrinkle composition can help to eliminate and reduce wrinkles, can supplement extracellular matrix and promote wound healing by stimulating synthesis of elastin, fibronectin, glycosaminoglycan and collagen (especially type I, type III and type IV collagen), repair broken collagen fibers, promote increase of collagen and promote synthesis of intercellular substance, so that skin can absorb effective components more easily, and is safe, convenient, non-allergic and continuously effective.
Preferably, the second anti-wrinkle composition comprises at least the following raw materials: euglena parvula polysaccharide and hydrolyzed collagen.
By adopting the technical scheme, the second anti-wrinkle composition composed of the hydrolyzed collagen and the fine euglena polysaccharide can deeply moisturize small molecule hydrolyzed collagen, tighten skin to fade wrinkles, permeate the bottom layer of the skin to repair damaged cells, and the fine euglena polysaccharide can form a tightening and breathable film on the surface layer of the skin, so that the skin is helped to immediately and permanently relieve fine wrinkles, and the integral anti-wrinkle effect is improved.
Preferably, the third anti-wrinkle composition comprises at least the following raw materials: water, 1, 2-pentanediol, and glycogen.
By adopting the technical scheme, the third anti-wrinkle composition has strong hydration capability, helps skin to generate ATP, increases the metabolic activity of fibroblasts, can improve skin barrier, improve skin luster and lighten black spots, is further beneficial to making skin color uniform, improves wrinkles and makes skin smooth.
In a second aspect, the application provides an anti-wrinkle essence emulsion, which adopts the following technical scheme:
an anti-wrinkle essence emulsion is prepared from the raw materials of components of A phase, B phase, C phase, D phase, E phase, F phase, G phase, H phase, I phase, J phase, K phase and L phase:
the phase A comprises the following raw materials in parts by weight: 18-22 parts of water; 0.25-0.35 parts of acrylic acid (ester) or C10-30 alkanol acrylate cross-linked polymer;
the phase B comprises the following raw materials in parts by weight: 35-45 parts of water; 0.1-5 parts of panthenol; 2.5-3.5 parts of glycerolyether-26; 0.15-0.25 parts of allantoin; 1.5-2.5 parts of betaine;
the phase C comprises the following raw materials in parts by weight: 2.5-3.5 parts of glycerol; 0.8-1.2 parts of polymethylsilsesquioxane;
the phase D comprises the following raw materials in parts by weight: 0.4-0.6 part of hydrogenated lecithin; 0.4-0.6 parts of cetyl alcohol ethylhexyl ester; 0.8-1.2 parts of squalane;
the phase E comprises the following raw materials in parts by weight: 1.1-1.3 parts of cyclopentadimethicone; 0.5 to 0.7 parts of a first emollient composition;
the phase F comprises the following raw materials in parts by weight: 0.18-0.24 part of tromethamine; 1.8-2.4 parts of water;
the phase G comprises the following raw materials in parts by weight: 0.4-0.6 part of p-hydroxyacetophenone; 4.5-5.5 parts of DPG; 2.5-3.5 parts of 1,3 propylene glycol;
the H phase comprises the following raw materials in parts by weight: 0.04-10 parts of adenosine; 0.01-5 parts of carnosine; 0.8-1.2 parts of water;
the phase I comprises the following raw materials in parts by weight: 0.1-10 parts of a second anti-wrinkle composition; 4-6 parts of water;
the J phase comprises the following raw materials in parts by weight: 0.1-5 parts of a first moisture-retaining composition; 0.01-5 parts of a second moisturizing composition; 0.1-20 parts of a first anti-wrinkle composition; 0.1-10 parts of a third anti-wrinkle composition; 0.001-0.5 parts of barley malt extract; 0.01-5 parts of a third moisturizing composition;
the K phase comprises the following raw materials in parts by weight: 1.3-1.7 parts of pentanediol; 0.15-0.25 part of phenoxyethanol;
the L phase comprises the following raw materials in parts by weight: 0.04-0.06 part of essence; 1.8-2.2 parts of dipropylene glycol.
By adopting the technical scheme, the anti-wrinkle composition is applied to the essence emulsion, and the component raw materials of the anti-wrinkle composition and the added auxiliary agent raw materials have good compatibility and combination property, so that a uniform and stable mixed system can be formed between the component raw materials, and an excellent and stable anti-wrinkle effect is exerted.
In a third aspect, the application provides a preparation method of anti-wrinkle essence emulsion, which adopts the following technical scheme:
a preparation method of anti-wrinkle essence milk comprises the following steps:
(1) Preparing raw materials of each component of A phase, B phase, C phase, D phase, E phase, F phase, G phase, H phase, I phase, J phase, K phase and L phase according to a proportion;
(2) Stirring and mixing the raw materials of each component in the phase A, wherein the stirring speed is 200-400rpm, and the stirring time is 50-70min;
(3) Weighing the raw materials of each component in the phase B into a main pot, stirring and mixing uniformly, adding the phase A which is uniformly mixed in the step (2), heating to 75-85 ℃, homogenizing for 3-5min at 2500-3500rpm, and stirring for 15-25min at the stirring speed of 200-400rpm;
(4) Uniformly dispersing the raw materials of each component in the phase C, adding the raw materials into a main pot, and homogenizing for 3-5min at 2500-3500 rpm; heating the raw materials of each component in the phase D to 70-80 ℃, adding the raw materials into a main pot after dissolving uniformly, and homogenizing for 3-5min at 4000-6000 rpm; then evenly mixing the raw materials of each component in the E phase, adding the mixture into a main pot, and evenly stirring at the stirring speed of 400-600rpm for 4-6min;
(5) Cooling the main pot to 55-60 ℃, then uniformly mixing the raw materials of each component in the F phase, adding the mixture, and uniformly stirring the mixture; heating the raw materials of each component in the G phase to 55-60 ℃, adding the raw materials into a main pot, and uniformly stirring;
(6) Cooling the main pot to 40-50 ℃, then uniformly mixing the raw materials of all components in the H phase, adding the mixture, and uniformly stirring the mixture; uniformly mixing the raw materials of all the components in the phase I, adding the mixture into a main pot, and uniformly stirring; then evenly mixing the raw materials of all the components in the J phase, adding the mixture into a main pot, and evenly stirring;
(7) Cooling the main pot to 35-40 ℃, then uniformly mixing the raw materials of all components in the K phase, adding the mixture, and uniformly stirring the mixture; and adding the mixed L phase into a main pot, uniformly stirring, filtering, and discharging to obtain the anti-wrinkle essence emulsion.
By adopting the technical scheme, the preparation method is favorable for fully mixing the raw materials of all the components together, forming a uniform and stable dispersion system among the raw materials of all the components, and ensuring that the whole essence emulsion can exert a good and stable anti-wrinkle effect in the application process on the premise of ensuring that the essence emulsion has good quality.
In summary, the application has the following beneficial effects:
the panthenol, the adenosine and the carnosine can play a good role in compounding and synergism, promote and activate the metabolism of the weak cells, activate the activity and metabolism of the aging cells, improve the antioxidants in the aging cells, increase the generation of collagen precursors in the aging cells, and further enable the skin barrier to be quickly self-repaired after being damaged, thereby playing an excellent anti-wrinkle effect.
Detailed Description
The present application will be described in further detail with reference to examples.
Examples
Example 1
An anti-wrinkle essence emulsion is applied, the components and the corresponding weight parts are shown in table 1, and the anti-wrinkle essence emulsion is prepared by the following steps:
(1) Preparing raw materials of each component of A phase, B phase, C phase, D phase, E phase, F phase, G phase, H phase, I phase, J phase, K phase and L phase according to a proportion;
(2) Stirring and mixing the raw materials of each component in the phase A, wherein the stirring speed is 300rpm, and the stirring time is 60min;
(3) Weighing the raw materials of each component in the phase B into a main pot, stirring and mixing uniformly, adding the uniformly mixed phase A in the step (2), heating to 80 ℃, homogenizing for 3min at 3000rpm, and carrying out heat preservation and stirring for 20min at the stirring speed of 300rpm;
(4) After uniformly dispersing the raw materials of each component in the phase C, adding the raw materials into a main pot, and homogenizing for 3min at 3000 rpm; heating the raw materials of each component in the phase D to 75 ℃, adding the raw materials into a main pot after dissolving uniformly, and homogenizing for 5min at 5000 rpm; immediately mixing the raw materials of the components in the phase E uniformly, adding the mixture into a main pot, and stirring uniformly at a stirring speed of 500rpm for 5min;
(5) Cooling the main pot to 60 ℃, then uniformly mixing the raw materials of each component in the F phase, adding the mixture, and uniformly stirring the mixture; heating the raw materials of each component in the G phase to 60 ℃, adding the raw materials into a main pot, and uniformly stirring;
(6) Cooling the main pot to 45 ℃, then uniformly mixing the raw materials of all the components in the H phase, adding the mixture, and uniformly stirring the mixture; uniformly mixing the raw materials of all the components in the phase I, adding the mixture into a main pot, and uniformly stirring; then evenly mixing the raw materials of all the components in the J phase, adding the mixture into a main pot, and evenly stirring;
(7) Cooling the main pot to 38 ℃, then uniformly mixing the raw materials of all the components in the K phase, adding the mixture, and uniformly stirring the mixture; and adding the mixed L phase into a main pot, uniformly stirring, filtering, and discharging to obtain the anti-wrinkle essence emulsion.
Note that: the first moisture-retaining composition of the above procedure was purchased from Shanghai Qiu Yan trade company, inc.; the second moisturizing composition is purchased from Shanghai iridescent corporation; the third moisturizing composition is available from Shanghai dry chemical Co., ltd; the first anti-wrinkle composition was purchased from Shanghai long-court chemical industry Co., ltd; the second anti-wrinkle composition was purchased from Shanghai long-court chemical industry Co., ltd; the third anti-wrinkle composition is available from Shanghai dry chemical Co., ltd; the first emollient composition is available from Shanghai chemical Co.Ltd; barley malt extract was purchased from Shanghai Rui trade Co., ltd; acrylic acid (esters)/C10-30 alkanol acrylate crosslinked polymers are available from Shanghai megaly industries developing Co., ltd; essence was purchased from guangdong Ming Kang Xiangjing fragrance limited.
Examples 2 to 7
An anti-wrinkle essence emulsion is different from example 1 in that each component and its corresponding parts by weight are shown in table 1.
Table 1 Components in examples 1 to 7 and parts by weight thereof
Comparative example
Comparative example 1
An anti-wrinkle essence emulsion is different from example 1 in that the ingredients in the B phase do not contain panthenol.
Comparative example 2
An anti-wrinkle essence emulsion is different from example 1 in that the components in the H phase do not contain adenosine.
Comparative example 3
An anti-wrinkle essence emulsion is different from example 1 in that the ingredients in the H phase do not contain carnosine.
Comparative example 4
An anti-wrinkle essence emulsion is different from example 1 in that the component in the B phase does not contain panthenol and the component in the H phase does not contain adenosine.
Comparative example 5
An anti-wrinkle essence emulsion is different from example 1 in that the component in the B phase does not contain panthenol and the component in the H phase does not contain carnosine.
Comparative example 6
An anti-wrinkle essence emulsion is different from example 1 in that the components in the H phase do not contain adenosine and carnosine.
Comparative example 7
An anti-wrinkle essence emulsion is different from example 1 in that the component in the B phase does not contain panthenol, and the component in the H phase does not contain adenosine and carnosine.
Comparative example 8
An anti-wrinkle essence emulsion is different from example 1 in that the weight part of panthenol in the B phase is 0.09 part.
Comparative example 9
An anti-wrinkle essence emulsion is different from example 1 in that the weight part of panthenol in the B phase is 5.1 parts.
Comparative example 10
An anti-wrinkle essence emulsion is different from example 1 in that the weight part of adenosine in the H phase is 10.1 parts.
Comparative example 11
An anti-wrinkle essence emulsion is different from example 1 in that the weight part of adenosine in the H phase is 0.03 part.
Comparative example 12
An anti-wrinkle essence emulsion is different from example 1 in that the weight part of carnosine in the H phase is 0.009 part.
Comparative example 13
An anti-wrinkle essence emulsion is different from example 1 in that the weight part of carnosine in the H phase is 5.1 parts.
Performance test samples: the anti-wrinkle essence milk obtained in examples 1 to 7 was used as test samples 1 to 7, and the anti-wrinkle essence milk obtained in comparative examples 1 to 13 was used as control samples 1 to 13.
The efficacy test index I of the application: elastic R2 value
Test instrument: german CK skin elasticity tester MPA 580
The test principle is as follows:
the skin elasticity tester is a special instrument for measuring the elasticity of the surface layer of the skin, and mechanically deforms the skin by negative pressure. The measurement principle is based on inhalation. The instrument generates negative pressure to suck the skin into the aperture of the probe and release the skin after a period of time. The depth of skin penetration into the probe is measured by a non-contact optical system. The optical measuring system consists of a light source, a light receiver and two prisms facing each other, and the light receiver receives light from the emitter. The light intensity varies due to the penetration depth of the skin. The ability of the skin to resist negative pressure (compaction) and return to its original state (elasticity) during the measurement is shown graphically (length of stretch/time). This test principle allows us to understand the elastic and mechanical properties of the skin surface and to quantitatively and objectively analyze the skin age. The test probe of this experiment gave a curve, so a parameter was recorded as a reference for skin elasticity, r2= (e (a) -e (a+b))/e (a) =ua/uf=total elastoplasticity of the rebound portion (blue distance/black distance-total elasticity). The closer the value is to 1 (100%) the more elastic the curve is, a very important parameter, often used by the literature, so this experimental reference data records the R2 value, which indicates skin elasticity.
The testing method comprises the following steps:
the experiment selects 60 subjects with healthy skin and ages of 20-35 years, and the subjects are divided into 20 groups, and one group of three persons is used for parallel control. The skin elasticity of the test examples and control samples was measured, R2 values were recorded, and the mean change after 1 month and the mean change after 2 months for each sample was calculated for each of the 3 subjects and the subjects were required to avoid exposure to sunlight for as long as possible during the course of the project.
Test condition preparation: the test environment in which the experiment was carried out was kept constant at a temperature of 20℃and a relative humidity of 50%. Since thermal radiation can lead to inaccurate measurements, direct measurement of sunlight is kept avoided and the subject is required to avoid direct irradiation of sunlight during the test time so as not to bring about deviation of experimental results.
Subject preparation: the subjects were asked to make a simple clean and rest in the test laboratory for 30 minutes before the time of the test with informed consent of the subjects, and during the adaptation environment, the measured area was not blocked by clothing, emotional stress could also lead to increased evaporation and increased blood circulation, ensuring that the adaptation room was calm.
The formal start test time is 9 days earlier, and the initial value before the test subjects do not use the sample is measured on the first day, and one pump of the same product is used in the morning and evening for every three subjects. After 1 month, skin elasticity was measured for the same test area of the cheek, three times, and the average value of the three tests was recorded, and after 2 months, the operation was repeated, and the test was completed.
Test results:
average value Δ1 of skin elasticity change after 1 month of use of example 1 = [ (skin elasticity value after 1 month of use-initial value of skin elasticity before use of subject 1)/initial value of skin elasticity before use of subject 1 + (skin elasticity value after 1 month of use of subject 2-initial value of skin elasticity before use of subject 2)/initial value of skin elasticity before use of subject 2 + (skin elasticity value after 1 month of use of subject 3-initial value of skin elasticity before use of subject 3)/initial value of skin elasticity before use of subject 3 ]. 100%/3.
Average value Δ2 of change in skin elasticity after 2 months of use = [ (initial value of skin elasticity after 2 months of use of subject 1-initial value of skin elasticity before use of subject 1)/initial value of skin elasticity before use of subject 1 + (initial value of skin elasticity after 2 months of use of subject 2-initial value of skin elasticity before use of subject 2)/initial value of skin elasticity before use of subject 2 + (initial value of skin elasticity after 2 months of use of subject 3-initial value of skin elasticity before use of subject 3)/initial value of skin elasticity before use of subject 3 ]. 100%/3.
Example 2 was done by subjects 4, 5, 6, example 3 was done by subjects 7, 8, 9, and so on, brought into the above formula.
The specific results are shown in Table 2
TABLE 2 average values of skin elasticity changes after 1 month and after 2 months for each three groups of 60 subjects using the same sample
The efficacy test index II of the application: wrinkle area ratio.
Test instrument: american face image analyzer VISIA-CR
The test principle is as follows:
the United states company combines years of clinical experience with the most advanced digital camera technology, and provides a professional facial image photographing and analyzing system VISIA-CR for skin researchers. Whether quantitative or qualitative, or both, the VISIA-CR can provide you with a very professional standard photographing method, allowing the following analysis of the skin: wrinkles and fine lines skin photodamage, skin texture, vascular characteristics, skin color and uniformity, porphyrin (acne).
The VISIA-CR has a variety of light source modes: standard light, UV light, cross polarized light, parallel polarized light. Due to the use of multiple light sources, the visual-CR greatly enhances the visibility of the skin to be analyzed.
The proprietary RBX technology gathers a great deal of research experience of colorimetry, provides melanin and vascular conditions of the lower layer of the skin for a great number of researchers, and is a brand new method for detecting, displaying and analyzing the lower layer of the skin. One photographing process comprises a plurality of light source modes, and at most seven pictures can be obtained.
The VISIA-CR is a face image photographing system which is simple and flexible to operate and accurate to control, and has the following characteristics:
1. the photographing of the high freshness image is completed within a few seconds.
2. The shooting time is short, the efficiency is high, and the subject can more easily keep a correct shooting position in the shooting process.
3. For different skin conditions, a preset light source pattern recommended by a clinical expert may be selected from the instrument.
4. Good repeatability of the test result is ensured through the target positioning and image ghost preview functions.
5. The built-in image capturing control function greatly reduces the possibility of misoperation of operators.
The VISIA-CR instrument is provided with specialized Mirror Photo Tools image management special software, and the shot images can be directly stored in a computer, so that the search and the image comparison are facilitated. All the images shot by the VISIA-CR can be searched according to file attributes or various parameters customized by users, and a new method for managing databases of a large number of images is provided for researchers. The base database images can be browsed and different images under the same subject name. The software has the functions of importing, exporting and renaming the images, and prints out according to the content required by the clients, so that the software is a very useful tool for researchers. The Photo Tools software also has the following functions:
1. distance, angle, area and percentage can be measured. 2. Images at different times are compared on the screen, the treatment result of the subject is tracked, and the test result is displayed. 3. The partial image enlarging function can carefully study the improvement condition of the skin. 4. The image can be conveniently marked, analyzed and written.
In the experiment, the wrinkle area ratio in the same AOI selected area is selected to reflect the anti-aging effect of each sample, and the smaller the numerical value is, the smaller the representation is, and the better the anti-wrinkle effect is. The wrinkle area ratio refers to the proportion of the wrinkle area in the AOI field to the total AOI field area.
The testing method comprises the following steps:
the experimental subjects and skin elasticity test subjects are in the same batch, each subject is subjected to a wrinkle area ratio test by using VISA-CR after the skin elasticity test is finished, wrinkle area ratio values are recorded, the average value of the wrinkle area ratio change of each sample after 3 subjects use for 1 month and the average value of the wrinkle area ratio change after use for 2 months are calculated for relevant evaluation, and the subjects are required to avoid exposure to sunlight for as long as possible during the project proceeding period.
Test results:
average change in skin wrinkle area ratio after 1 month of use Δ3= [ (initial skin wrinkle area ratio before use of subject 1: initial skin wrinkle area ratio before use of subject 1)/(initial skin wrinkle area ratio before use of subject 1 + (initial skin wrinkle area ratio before use of subject 2: initial skin wrinkle area ratio after use of subject 2) initial skin wrinkle area ratio before use of subject 2 + (skin wrinkle area ratio after use of subject 3: initial skin wrinkle area ratio before use of subject 3)/(initial skin wrinkle area ratio before use of subject 3 ]. 100%/3) of example 1.
Average change in skin wrinkle area after 2 months of use Δ4= [ (initial skin wrinkle area ratio before use of subject 1 to initial skin wrinkle area ratio after use of subject 1 to 2 months)/initial skin wrinkle area ratio before use of subject 1 + (initial skin wrinkle area ratio before use of subject 2 to 2 months) initial skin wrinkle area ratio before use of subject 2 + (initial skin wrinkle area ratio after use of subject 3 to 2 months-initial skin wrinkle area ratio before use of subject 3 to initial skin wrinkle area ratio before use of subject 3)/initial skin wrinkle area ratio before use of subject 3 ]. 100%/3.
Example 2 was done by subjects 4, 5, 6, example 3 was done by subjects 7, 8, 9, and so on, brought into the above formula.
The specific results are shown in Table 3
Table 3 average of skin wrinkle area ratio changes after 1 month and after 2 months of use of the same sample for each three groups of 60 subjects
| Sample of | Δ3 | Δ4 |
| Example 1 | -16.69％ | -17.13％ |
| Example 2 | -4.67％ | -9.68％ |
| Example 3 | -9.30％ | -14.13％ |
| Example 4 | -3.54％ | -7.51％ |
| Example 5 | -7.39％ | -7.21％ |
| Example 6 | -4.05％ | -4.31％ |
| Example 7 | -3.18％ | -3.91％ |
| Control 1 | -1.86％ | -1.85％ |
| Control sample 2 | -1.62％ | -1.53％ |
| Control sample 3 | -1.86％ | -1.47％ |
| Control sample 4 | -1.24％ | -1.38％ |
| Control 5 | -1.56％ | -1.36％ |
| Control 6 | -1.23％ | -0.64％ |
| Control sample 7 | -0.94％ | -0.33％ |
| Control sample 8 | -2.52％ | -2.94％ |
| Control sample 9 | -2.99％ | -3.24％ |
| Control sample 10 | -2.72％ | -3.61％ |
| Control 11 | -2.55％ | -2.01％ |
| Control 12 | -2.24％ | -2.04％ |
| Control sample 13 | -3.03％ | -2.86％ |
Test results: as can be obtained by comparing the test results of example 1 and examples 2 to 7, example 1 is an optimal ratio combination of the components of the anti-wrinkle essence emulsion, and wherein the ratio of the components of the anti-wrinkle composition is also the optimal ratio combination. The test results of example 1 and comparative examples 1 to 7 are compared with each other, so that good compound synergism can be achieved among panthenol, adenosine and carnosine, and the effect brought by the synergistic interaction of any one or two of panthenol, adenosine and carnosine is far less excellent than that brought by the synergistic interaction of the panthenol, the adenosine and the carnosine. As can be seen from the comparison of the test results of example 1 and comparative examples 8 to 13, the amounts of panthenol, adenosine and carnosine which are used in excess of the prescribed range, either too much or too little, significantly reduce the overall efficacy of the anti-wrinkle composition.
The present embodiment is only for explanation of the present application and is not to be construed as limiting the present application, and modifications to the present embodiment, which may not creatively contribute to the present application as required by those skilled in the art after reading the present specification, are all protected by patent laws within the scope of claims of the present application.
Claims (2)
1. An anti-wrinkle essence emulsion is characterized in that: the composite material is prepared from the following raw materials of components of A phase, B phase, C phase, D phase, E phase, F phase, G phase, H phase, I phase, J phase, K phase and L phase:
the phase A consists of the following raw materials in parts by weight: 18-22 parts of water; 0.25-0.35 parts of acrylic acid (ester) or C10-30 alkanol acrylate cross-linked polymer;
the phase B consists of the following raw materials in parts by weight: 35-45 parts of water; 0.1-5 parts of panthenol; 2.5-3.5 parts of glycerolyether-26; 0.15-0.25 parts of allantoin; 1.5-2.5 parts of betaine;
the phase C consists of the following raw materials in parts by weight: 2.5-3.5 parts of glycerol; 0.8-1.2 parts of polymethylsilsesquioxane;
the phase D consists of the following raw materials in parts by weight: 0.4-0.6 part of hydrogenated lecithin; 0.4-0.6 parts of cetyl alcohol ethylhexyl ester; 0.8-1.2 parts of squalane;
the phase E consists of the following raw materials in parts by weight: 1.1-1.3 parts of cyclopentadimethicone; 0.5 to 0.7 parts of a first emollient composition;
the phase F consists of the following raw materials in parts by weight: 0.18-0.24 part of tromethamine; 1.8-2.4 parts of water;
the phase G consists of the following raw materials in parts by weight: 0.4-0.6 part of p-hydroxyacetophenone; 4.5-5.5 parts of dipropylene glycol; 2.5-3.5 parts of 1,3 propylene glycol;
the H phase consists of the following raw materials in parts by weight: 0.04-10 parts of adenosine; 0.01-5 parts of carnosine; 0.8-1.2 parts of water;
the phase I consists of the following raw materials in parts by weight: 0.1-10 parts of a second anti-wrinkle composition; 4-6 parts of water;
the phase J consists of the following raw materials in parts by weight: 0.1-5 parts of a first moisture-retaining composition; 0.01-5 parts of a second moisturizing composition; 0.1-20 parts of a first anti-wrinkle composition; 0.1-10 parts of a third anti-wrinkle composition; 0.001-0.5 parts of barley malt extract; 0.01-5 parts of a third moisturizing composition;
the K phase consists of the following raw materials in parts by weight: 1.3-1.7 parts of 1,2 pentanediol; 0.15-0.25 part of phenoxyethanol;
the L phase consists of the following raw materials in parts by weight: 0.04-0.06 part of essence; 1.8-2.2 parts of dipropylene glycol;
the first moisture-preserving composition is composed of the following raw materials: saccharide isomers, water, citric acid and sodium citrate;
the second moisturizing composition is composed of the following raw materials: water, honey extract and 1, 3-propanediol;
the third moisturizing composition is composed of the following raw materials: butanediol, 1, 2-hexanediol, bacillus/soybean fermentation product extract, folic acid and sodium hyaluronate;
the first anti-wrinkle composition consists of the following raw materials: palmitoyl pentapeptide-4, water, glycerol, butylene glycol, carbomer, sodium lactate, and polysorbate-20;
the second anti-wrinkle composition consists of the following raw materials: a euglena parvula polysaccharide and hydrolyzed collagen;
the third anti-wrinkle composition consists of the following raw materials: water, 1, 2-pentanediol, and glycogen.
2. The method for preparing anti-wrinkle essence emulsion according to claim 1, comprising the following steps:
(1) Preparing raw materials of each component of A phase, B phase, C phase, D phase, E phase, F phase, G phase, H phase, I phase, J phase, K phase and L phase according to a proportion;
(2) Stirring and mixing the raw materials of each component in the phase A, wherein the stirring speed is 200-400rpm, and the stirring time is 50-70min;
(3) Weighing the raw materials of each component in the phase B into a main pot, stirring and mixing uniformly, adding the phase A which is uniformly mixed in the step (2), heating to 75-85 ℃, homogenizing for 3-5min at 2500-3500rpm, and stirring for 15-25min at the stirring speed of 200-400rpm;
(4) Uniformly dispersing the raw materials of each component in the phase C, adding the raw materials into a main pot, and homogenizing for 3-5min at 2500-3500 rpm; heating the raw materials of each component in the phase D to 70-80 ℃, adding the raw materials into a main pot after dissolving uniformly, and homogenizing for 3-5min at 4000-6000 rpm; then evenly mixing the raw materials of each component in the E phase, adding the mixture into a main pot, and evenly stirring at the stirring speed of 400-600rpm for 4-6min;
(5) Cooling the main pot to 55-60 ℃, then uniformly mixing the raw materials of each component in the F phase, adding the mixture, and uniformly stirring the mixture; heating the raw materials of each component in the G phase to 55-60 ℃, adding the raw materials into a main pot, and uniformly stirring;
(6) Cooling the main pot to 40-50 ℃, then uniformly mixing the raw materials of all components in the H phase, adding the mixture, and uniformly stirring the mixture; uniformly mixing the raw materials of all the components in the phase I, adding the mixture into a main pot, and uniformly stirring; then evenly mixing the raw materials of all the components in the J phase, adding the mixture into a main pot, and evenly stirring;
(7) Cooling the main pot to 35-40 ℃, then uniformly mixing the raw materials of all components in the K phase, adding the mixture, and uniformly stirring the mixture; and adding the mixed L phase into a main pot, uniformly stirring, filtering, and discharging to obtain the anti-wrinkle essence emulsion.
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