KR101796462B1 - Cosmetic composition comprising adenosine and arbutin for regenerating skin and improving skin wrinkle - Google Patents

Abstract

The present invention relates to a cosmetic composition for skin wrinkle improvement and skin reproduction. The present invention comprises: 0.01 wt% of caprlic/capric triglyceride; 0.01 wt% of isethihexapeptide-8; 0.007999 wt% of glyceryl polymethacrylates; 0.002 wt% of propylene glycol; 0.00003 wt% of soybean oil; 0.00002 wt% of phenoxyethanol; 0.00001 wt% of lecithin; 0.0000012 wt% of sodium ascorbyl phosphate; 0.000001 wt% of mitoyl oligopeptide; and 0.0000001 wt% of human oligopeptide. As such, the present invention is capable of effectively preventing skin aging by providing excellent wrinkle improvement and elasticity improvement.

Description

[0001] The present invention relates to a cosmetic composition comprising adenosine and arbutin for improving skin regeneration and skin wrinkles,

The present invention relates to a cosmetic composition for skin regeneration and skin wrinkle improvement comprising adenosine and arbutin. More particularly, the present invention relates to a cosmetic composition containing adenosine, a wrinkle improving protein and a polypeptide, The present invention also relates to a cosmetic composition for skin regeneration and skin wrinkle improvement comprising adenosine and arbutin, which has a whitening effect by inhibiting melanin pigment through an arbutin component and can effectively prevent skin aging.

The present invention also relates to a method for the treatment and prophylaxis of cell growth and proliferation, which comprises the removal of harmful oxygen and inflammation, including the HAZZEL, SONOG and green tea extracts, the moisturizing with high concentration of sodium hyaluronate (hyaluronic acid) The present invention relates to a cosmetic composition for skin regeneration and skin wrinkle improvement comprising adenosine and arbutin having a regenerating effect.

The skin is largely divided into three layers: epidermis, dermis, and subcutaneous tissue in order from the outside. It has a function to protect the internal organs of the body from changes in temperature and humidity, ultraviolet rays, and other physical and chemical external stimuli.

In particular, the epidermis plays an important role in preventing water evaporation inside the human body. The epidermis is divided into stratum corneum, granular layer, superficial layer, and basal layer in order from the outside. Cells of stratum corneum act like bricks, and intercellular lipids between keratinocytes act like mortar to constitute skin barrier. In addition, a healthy human keratinocyte has a high concentration of natural moisturizing factor (NMF) to help maintain moisture in the skin. For example, substances such as amino acids are water-soluble, Thereby suppressing drying.

Skin wrinkles are caused by accumulation of peroxidized lipids harmful to the skin, which promotes skin aging. Skin shrinking elasticity It is oxidized to unsaturated fatty acid in the body to increase lipid peroxidation in the body, so that the fiber which maintains elasticity of skin is vulnerable to skin wrinkle. Is known to cause skin wrinkles and aging shrinkage convergence due to skin aging phenomena such as pigmentation, decrease in skin elasticity and shrinking skin color, and atrophy of nucleus. In the embodiment, the converging action reduces (contracts) the pores and gives skin tension, thereby giving skin elasticity.

In the case of poor circulation of the skin, which is the main cause of skin aging of the skin, inadequate nutrition, degeneration and atrophy of the elastic fiber-binding fiber muscle fiber in the dermis leads to decrease of moisture and skin fat, When the free radicals are generated in the oxygen, when the collagen is deficient, and when the activity of elastase, which is a decomposition factor of elastic fiber, is increased, various kinds of causes weaken the elasticity of the skin and the shrinkability of the pores.

However, as it is nowadays, there is a tendency to adjust the temperature of the air / heating due to the change of environment or life pattern, the stress caused by various stresses and environmental pollution in the social life, frequent washing according to make- Due to various causes such as aging of skin and the like, moisture of the stratum corneum is reduced, and the skin becomes dry, the surface becomes rough, the skin becomes loose, the luster is lost and the skin looks dull, and the need for skin moisturizing agent is increasing.

Therefore, it is derived from a natural product which exhibits a skin aging prevention, a skin regeneration and a moisturizing effect on the skin, alleviates the generation and propagation of causative bacteria of wrinkles, exhibits a sufficient skin improving effect but does not exhibit secondary side effects A new composition containing one component as a main component is required.

[Related Technical Literature]

1. Cosmetic composition for skin miosture (Patent Application No. 10-2004-0083125)

2. Cosmetic composition comprising earth worm mucus and mud as an active ingredient for improving skin regeneration and skin wrinkle (Patent No. 10-1267321 )

SUMMARY OF THE INVENTION The present invention has been made to overcome the above problems, and it is an object of the present invention to provide an anti-wrinkle treatment composition comprising adenosine, a wrinkle-improving protein and a polypeptide, The present invention provides a cosmetic composition for skin regeneration and skin wrinkle improvement comprising adenosine and arbutin, which has a whitening effect by inhibiting pigmentation and can effectively prevent skin aging.

The present invention also relates to a method for the treatment and prophylaxis of cell growth and proliferation, which comprises the removal of harmful oxygen and inflammation, including the HAZZEL, SONOG and green tea extracts, the moisturizing with high concentration of sodium hyaluronate (hyaluronic acid) And to provide a cosmetic composition for skin regeneration and skin wrinkle improvement comprising adenosine and arbutin having a regenerating effect.

According to an aspect of the present invention for achieving the above object, there is provided a skin regeneration and skin wrinkle improvement including a combination of adenosine and arbutin, sodium hyalulonate and butylene glycol, polyglutamic acid, glycerin and ethanol To provide a cosmetic composition for use in cosmetics.

Further, the cosmetic composition for skin regeneration and skin wrinkle improvement according to the embodiment of the present invention is characterized in that the combination comprises 0.02 to 1% of adenosine; 1.5 to 3.5% arbutin; 2.5 to 4.0% of sodium hyaluronate; Butylene glycol 1.54 to 3.12%; 1 to 2.5% of polyglutamic acid; 0.5 to 1.7% of glycerin; 0.8 to 2.3% of ethanol and the remaining material.

In addition, the cosmetic composition for skin regeneration and skin wrinkle improvement according to the embodiment of the present invention is characterized in that the combination contains 86.0759373 wt% of purified water, 3.00 wt% of sodium hyaluronate, 2.30 wt% of butylene glycol, 2.00 wt 1.50% by weight of polyglutamic acid, 1.50% by weight of ethanol, 1.00% by weight of glycerin, 1.00% by weight of 1,2-hexanediol, 0.60% by weight of phage-60 hydrogenated castor oil, 0.50% by weight of hydrolyzed elastin 0.10% by weight of betaine, 0.10% by weight of green tea extract, 0.10% by weight of locust bean extract, 0.05% by weight of camellia oil, 0.05% by weight of flavor, 0.04% by weight of adenosine, 0.034% by weight of caramel, 0.01% by weight of caprylic / capric triglyceride, 0.01% by weight of isecylhexapeptide-8, 0.007999% by weight of glyceryl polymethacrylate, 0.002% by weight of propylene glycol, 0.00003% by weight of soybean oil, 0.00002% by weight of ethanol, lecithin 0.0 0001 weight% of sodium ascorbyl phosphate, 0.0000012 weight% of sodium ascorbyl phosphate, 0.000001 weight% of a mitochondrial oligopeptide, and 0.0000001 weight% of a human oligopeptide-1.

The cosmetic composition for skin regeneration and skin wrinkle improvement comprising adenosine and arbutin according to the present invention may contain adenosine, wrinkle-improving protein and polypeptide, which are certified as wrinkle-improving components, to improve the elasticity shortage from fine wrinkles to deep neck wrinkles.

In addition, the cosmetic composition for skin regeneration and skin wrinkle improvement comprising adenosine and arbutin according to the present invention has harmful oxygen elimination and inflammation-enhancing effects including locust, sesame and green tea extracts, and highly concentrated sodium hyaluronate Lonic acid) is abundant, moisturizing, contains growth factor protein EGF, and has cell growth promotion and regeneration effect.

In addition, the cosmetic composition for skin regeneration and skin wrinkle improvement comprising adenosine and arbutin according to the present invention has a whitening effect by inhibiting melanin pigment through arbutin component, and is excellent in stability and persistence in penetration of the skin because it is an intracellular component. And adenosine which promotes protein synthesis, synergistic effects are exhibited to improve skin wrinkles and skin elasticity, thereby effectively preventing skin aging.

In addition, the cosmetic composition for skin regeneration and skin wrinkle improvement comprising adenosine and arbutin according to the present invention has no cytotoxicity and is safe for skin and has a wrinkle-reducing effect such as wrinkles, jaw wrinkles, neck wrinkles and chest wrinkles It has excellent skin protection and moisturizing effect, and it provides relaxation effect and emotional stability effect through olfactory sense.

1 is a skin rejuvenation test report of a cosmetic composition for skin regeneration and skin wrinkle improvement according to the present invention.
FIG. 2 is a view showing a wrinkle improvement and a skin improvement state of a cosmetic composition for skin regeneration and skin wrinkle improvement according to the present invention. FIG.

Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings.

However, the following examples are provided only for the purpose of easier understanding of the present invention, and the present invention is not limited by the examples.

The cosmetic composition for skin regeneration and skin wrinkle improvement comprising adenosine and arbutin according to the present invention contains a number of substances such as adenosine, arbutin, sodium hyaluronate, and butyleneglycol to promote cell growth, skin regeneration, moisturization, and melanin Is provided for the whitening effect through pigment suppression.

Adenosine is a compound in which adenine and ribose are combined in a cellular component, and is a component of RNA and many coenzymes. Adenosine is a component of human body cells that penetrates into the skin. It has excellent stability and persistence. It has excellent stability to light and heat. It has DNA and protein It is a wrinkle-improving functional raw material that improves skin elasticity by activating the synthesis, restoring skin cell self-renewal ability, strengthening the proliferation of fibroblasts in the dermal layer and promoting collagen synthesis.

It is a raw material that has been reported as a wrinkle-improving functional ingredient in a pet food store, and it can be certified as a wrinkle-improving functional cosmetic by adding 0.04% to a cosmetic product.

It is mainly used in products that help prevent skin aging or in products that promote skin elasticity. It helps restore vitality to the skin and gives vitality to tired skin.

Arbutin is a natural sugar derivative which exists in a large amount in BEARBERRY which grows in a mountainous region. It inhibits the activity of tyrosinase, which is a main enzyme of melanin pigment production, as a safe whitening ingredient without adverse effect on human body, It acts on the enzyme "TYROSINASE", which produces the melanin pigment, which inhibits the formation of melanin pigment of spots, freckles, and lights caused by abnormal pigment accumulation.

The inhibitory effect of arbutin on melanin production is not cytotoxic to melanocytes such as hyaluronic acid mozobenzyl ether but is due to inhibition of tyrosinase activity or inhibition of biosynthesis and has excellent effect on improvement of skin pigmentation without irritation to human body have.

In addition, when used together with vitamin C, the whitening effect can be enhanced and the pigment deposition generated by ultraviolet irradiation can be effectively inhibited.

Sodium hyaluronate is a sodium salt of hyaluronic acid, a component of chicken chicken, which is a kind of mucopolysaccharide and has a water content of 6,000 times. It has excellent natural moisturizing factor (NMF )to be,

In addition, sodium hyaluronate is called hyaluronic acid. It is a basic substance that fills the space between collagen and elastin of the skin. It is a typical moisturizing ingredient which prevents skin from getting rough by preventing loss of moisture. Its structure is β-N -Acetyl-D-glucosamine and? -D-glucuronic acid, and has a molecular weight of usually 50,000 to 10,000,000 Da or more. Sodium hyaluronate is the basic material of the bio-connective tissues and is mainly used for the skin of the mammals, synovial fluid of the joints, vitreous humor of the eyes, umbilical cord, serum, (cock's comb), etc., and it is known that they are also present in the subcircular layer of streptococcal species.

Natural sodium hyaluronate is a polydisperse acid which is proportional to the molecular weight and does not have interspecies specificity and does not have any tissue or organ specificity so that excellent biochemical synthesis can be obtained when transplanted or injected into a living body regardless of its origin And is used as an ophthalmic injection or the like.

Butylene glycol (Butanediol) is a dihydric alcohol with four carbon atoms and two hydroxyl groups (OH group), which is one more carbon number and one less hydroxyl group than glycerin. Depending on the location of the hydroxy group, The following structure is the structure of 1,3-butanediol.

It has two hydroxy groups (OH groups), which is strong in hydrophilic properties and attracts water in the air, which prevents the cosmetic from drying easily when applied to skin. It has similar characteristics to glycerin, but its viscosity is about 200 times as high as 20 degrees.

The cosmetic composition according to the present invention according to the present invention is prepared by an ampoule and injected by a nano gun to spray an effective ingredient of the composition on the forehead, eyes, face, and neck of a user to improve skin regeneration, Effect. When looking at the components,

The present invention provides, as an active ingredient,

a) adenosine and arbutin,

b) sodium hyaluronate and butylene glycol,

c) A liquid ampoule formulation comprising a combination of polyglutamic acid, glycerin and ethanol, to provide a cosmetic composition for skin regeneration and skin wrinkle improvement.

The compositions according to the present invention will contain a variety of active ingredients within the percentages by weight percent:

- adenosine: 0.02 to 1%;

- arbutin: 1.5 to 3.5%;

- 2.5 to 4.0% sodium hyaluronate;

- Butylene glycol: 1.54 to 3.12%

- polyglutamic acid: 1 to 2.5%

Glycerin: 0.5 to 1.7%

- ethanol: 0.8 to 2.3% and the remaining combination,

The compositions according to the present invention will contain a variety of active ingredients within the percentages by weight percent:

More specifically, the cosmetic composition for skin regeneration and skin wrinkle improvement of the present invention comprises

Hydroxybutyraldehyde, sodium hyaluronate, butylene glycol, arbutin, polyglutamic acid, ethanol, glycerin, 1,2-hexanediol, phage-60 hydrogenated castor oil, hydrolyzed elastin, betaine, Extract, locust extract, camellia oil, fragrance, adenosine, caramel, disodium edetate, caprylic / capric triglyceride, isecyl hexapeptide-8, glyceryl polymethacrylate, propylene glycol, soy Oil, phenoxyethanol, lecithin, sodium ascorbyl phosphate, a mitochondrial peptide, human oligopeptide-1 and purified water.

<Experimental Example>

 Detailed composition ratio for skin regeneration and skin wrinkle improvement ingredient Content (% by weight) Purified water 86.0759373 Sodium hyaluronate 3.00 Butylene glycol 2.30 Arbutin 2.00 Polyglutamic acid 1.50 ethanol 1.50 glycerin 1.00 1,2-hexanediol 1.00 PIGGY-60 Hydrogenated Castor Oil 0.60 Hydrolyzed elastin 0.50 Betaine 0.10 Green tea extract 0.10 Location of Hazel extract 0.10 Camellia oil 0.05 Spices 0.05 Adenosine 0.04 Caramel 0.034 Disodium iodide 0.0200014 Caprylic / capric triglyceride 0.01 Isetil hexapeptide-8 0.01 Glyceryl polymethacrylate 0.007999 Propylene glycol 0.002 Soybean oil 0.00003 Phenoxyethanol 0.00002 lecithin 0.00001 Sodium ascorbyl phosphate 0.0000012 Mitoyl oligopeptide 0.000001 Human Oligopeptide-1 0.0000001

According to the composition shown in Table 1, purified water, adenosine and arbutin, sodium hyaluronate, butylene glycol, polyglutamic acid, glycerin and ethanol were respectively weighed and then the other combinations were mixed The mixture was stirred for 10 minutes while maintaining the temperature at 2500 rpm at 78 ° C, and then added at 55 ° C. The mixture was further stirred for about 5 minutes and then cooled to 40 ° C to recover the skin including adenosine and arbutin A cosmetic composition for improvement was prepared.

Example

In order to measure skin regeneration, skin wrinkle improvement, moisturizing and whitening effect of the composition of the present invention including adenosine and arbutin, comparative examples were prepared by applying the following Table 2 and weight variably. Adenosine, sodium hyaluronate, and butylene glycol were used to confirm the effects of ampoule production.

 Composition ratio ingredient Example Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Sodium hyaluronate 3.00 3.00 3.00 2.77 4.00 Butylene glycol 2.30 2.75 2.45 2.56 3.12 Arbutin 2.00 1.68 1.75 2.23 1.88 Polyglutamic acid 1.50 1.50 1.50 1.50 1.50 ethanol 1.50 1.50 1.50 1.50 1.50 glycerin 1.00 1.00 1.00 1.00 1.00 1,2-hexanediol 1.00 1.00 1.00 1.00 1.00 PIGGY-60 Hydrogenated Castor Oil 0.60 0.60 0.60 0.60 0.60 Hydrolyzed elastin 0.50 0.50 0.50 0.50 0.50 Betaine 0.10 0.10 0.10 0.10 0.10 Green tea extract 0.10 0.10 0.10 0.10 0.10 Location of Hazel extract 0.10 0.10 0.10 0.10 0.10 Camellia oil 0.05 0.05 0.05 0.05 0.05 Spices 0.05 0.05 0.05 0.05 0.05 Adenosine 0.04 0.09 0.07 0.05 0.12 Caramel 0.034 0.034 0.034 0.034 0.034 Disodium iodide 0.0200014 0.0200014 0.0200014 0.0200014 0.0200014 Caprylic / capric triglyceride 0.01 0.01 0.01 0.01 0.01 Isetil hexapeptide-8 0.01 0.01 0.01 0.01 0.01 Glyceryl polymethacrylate 0.007999 0.007999 0.007999 0.007999 0.007999 Propylene glycol 0.002 0.002 0.002 0.002 0.002 Soybean oil 0.00003 0.00003 0.00003 0.00003 0.00003 Phenoxyethanol 0.00002 0.00002 0.00002 0.00002 0.00002 lecithin 0.00001 0.00001 0.00001 0.00001 0.00001 Sodium ascorbyl phosphate 0.0000012 0.0000012 0.0000012 0.0000012 0.0000012 Mitoyl oligopeptide 0.000001 0.000001 0.000001 0.000001 0.000001 Human Oligopeptide-1 0.0000001 0.0000001 0.0000001 0.0000001 0.0000001 Purified water Balance Balance Balance Balance Balance

(1) Test Example 1: First skin irritation test

In order to examine the skin irritation of the products manufactured according to the above examples, a predetermined amount (about 0.1 g) of each sample was applied to a 5 x 20 cm area on a lower arm portion of a healthy adult male and female for 24 hours After 1 hour and 24 hours, the change of skin condition was visually observed. The results are shown in Table 3. The criteria given in the following Table 3 are as follows, and the degree of irritation is calculated by the following equation:

* Criteria *

-: No erythema or unusual symptoms; + -: slightly reddish from the surroundings

Results of skin irritation measurement division Tested embroidery Judgment result Also, +++ - Example 50 - - 2 48 0.9 Comparative Example 1 50 - One 2 47 1.4 Comparative Example 2 50 - One 3 46 1.5 Comparative Example 3 50 - - 3 47 1.6 Comparative Example 4 50 - - One 49 1.8

As can be seen from the skin irritation test results in Table 3, the degree of irritation of the prepared ampule cosmetic material was the lowest in the examples, and the skin irritation was low overall.

(2) Test Example 2: Effect of improving skin wrinkles

The skin wrinkle improving effect of the cosmetic composition containing adenosine and arbutin of the present invention was measured in 50 healthy women aged 35 to 55 years. First, the group A was divided into five groups, the group A, the group B, the comparative example 1, the comparative example 2, the comparative example 3, the comparative example 3, and the comparative example 4 Was applied to the facial area twice a day (morning and evening) for 3 months. After 3 months, the improvement of wrinkles was evaluated by image analysis of questionnaires and wrinkles.

The subjects' questionnaires were judged to be four stages of no improvement, slight improvement, moderate improvement, and considerable improvement as compared with before use. The results are shown in Table 4.

The evaluation of the wrinkles by the image analysis was performed by taking a replica of the eyes and neck before the start of the experiment and collecting the replica immediately after the end of the experiment from the same part under the eyes and the neck and analyzing the image by two- The density of the wrinkles was measured. The measurement results of the wrinkle density by image analysis are shown in Table 5 as a reduction rate relative to the wrinkle density before use.

Wrinkle improvement degree measurement result sample No improvement Slight improvement Moderate improvement A significant improvement Example One 2 3 4 Comparative Example 1 3 3 2 2 Comparative Example 2 4 2 3 One Comparative Example 3 4 3 2 One Comparative Example 4 6 3 One One

Wrinkle reduction rate measurement result sample Wrinkle density reduction rate (%) Example 45 Comparative Example 1 35 Comparative Example 2 20 Comparative Example 3 20 Comparative Example 4 10

From Tables 4 and 5, it was found that the effect of improving the skin wrinkles was excellent in the ingredients of the examples of the cosmetic composition for skin regeneration and skin wrinkle improvement including adenosine and arbutin.

Further, as shown in FIG. 2, after the cosmetic composition for improving skin regeneration and skin wrinkles containing adenosine and arbutin according to the present invention is sampled, the state of improvement of wrinkles and skin regeneration before and after the sample is shown. Regeneration and wrinkle-improving effect can be obtained.

(3) Test Example 3: Skin elasticity

The skin elasticity enhancement effect of the cosmetic composition for skin regeneration and skin wrinkle improvement including adenosine and arbutin of the present invention was measured. 55 women (mean age 47 years) of healthy women over 35 years old were divided into five groups under the conditions of a temperature of 25 DEG C and a humidity of 75. The group A, the group B, the group C, (C), Group C (Comparative Example 3), and Group C (Comparative Example 4) were applied to the eye and face twice a day for 12 weeks (morning and evening), followed by skin elasticity meter (Cutometer MPA580, Conrage + Germany Federal Ministry of Health) to measure skin elasticity. The test results are shown as R2 (R2 (12 weeks) -R2 (0 weeks)) of the cutometer MPA580. The R2 value indicates the property of gross elasticity, and the results are shown in Table 6 below.

Skin elasticity measurement result Experimental formulation Skin elasticity effect Example 0.082 Comparative Example 1 0.069 Comparative Example 2 0.056 Comparative Example 3 0.043 Comparative Example 4 0.031

From Table 6, it was confirmed that the skin elasticity effect of the examples was increased through the cosmetic composition comprising adenosine and arbutin as compared with the comparative example.

(4) Test Example 4: Evaluation of skin improvement effect

When the ampoule of Example 1 and Comparative Examples 1 to 4 was used, skin moisturizing, whitening effect, skin soothing effect, and overall preference were evaluated as well as skin regeneration and wrinkle improvement.

Specifically, 50 women aged 35 to 55 years were divided into five groups based on the average age, the group A, the group B, the group C, the group C, and the group C (1: very bad - > 10: 1) after using the cosmetic composition of Comparative Example 4 for 2 weeks (twice a day (morning and evening) The test was performed using Duncan's multiple range test. As a result, the results shown in Table 7 were obtained.

Skin improvement measurement result Evaluation items Example Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Skin regeneration 9.6 ± 0.15 9.2 ± 0.29 9.0 ± 0.34 8.7 ± 0.16 8.4 ± 0.34 Skin moisturizing 9.3 ± 0.21 8.9 ± 0.34 8.4 ± 0.24 8.4 ± 0.35 8.0 ± 0.15 Whitening 9.1 ± 0.91 8.9 ± 0.48 8.6 ± 0.37 8.6 ± 0.56 8.2 ± 0.47 Skin soothing 9.0 ± 0.57 8.8 ± 0.23 8.6 ± 0.21 8.5 ± 0.69 8.1 ± 0.68 wrinkle improvement 9.4 ± 0.18 9.1 ± 0.28 8.7 ± 0.35 8.6 ± 0.23 8.3 ± 0.98 Overall preference 9.4 ± 0.44 8.9 ± 0.37 8.6 ± 0.68 8.4 ± 0.88 8.2 ± 0.45

As a result, as shown in Table 7, the ampule cosmetic composition prepared to be included in the composition range of the present invention showed excellent skin regeneration and wound healing effects as a whole as shown in Examples and Comparative Examples, For the overall preference, including moisturizing, whitening, skin soothing and wrinkle-reducing effects, the best effects and preferences were exhibited in the ampoules made in the examples.

That is, as shown in the attached FIG. 1, it can be seen that the skin regeneration and skin wrinkle improving cosmetic composition containing adenosine and arbutin of the present invention are effective for improving and stabilizing the skin according to skin rejuvenation test results.

Therefore, through the skin regeneration test result and the skin wrinkle improvement evaluation, it was confirmed that the cosmetic according to the present invention has high skin improving effect including skin regeneration and skin wrinkle improvement, and can be used as a cosmetic.

(5) Test Example 5: Stability test of formulation

The stability test of the inventive cosmetic containing adenosine and arbutin was carried out by the following method.

In order to test the stability of the cosmetic, the above Examples and Comparative Examples 1 to 4 were placed in an opaque glass container in a thermostat kept constant at 45 DEG C and stored for 12 weeks and stored in a completely lighted refrigerator kept constant at 4 DEG C After storage for 12 weeks in an opaque glass container, the degree of discoloration, separation, and separation were compared, and the results are shown in Table 8 below. At this time, the product discoloration, separation and degree of separation were classified into the following six grades and evaluated.

0: No change 1: Very little separation (discoloration)

2: slightly separated (discolored) 3: slightly discolored (discolored)

4: Severely separated (discolored) 5: Severely separated (discolored).

 Stability results of the formulation
division
Stability of formulation Example Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 45 ° C 4 ℃ 45 ° C 4 ℃ 45 ° C 4 ℃ 45 ° C 4 ℃ 45 ° C 4 ℃ discoloration 0 0 0 0 0 0 0 0 0 00 Fling 0 0 0 0 0 0 0 0 0 0 detach 0 0 0 0 0 0 0 0 0 0

As can be seen from Table 8, the examples and comparative examples were stable at 45 ° C with almost no discoloration, separation, or separation phenomenon, indicating that adenosine and arbutin exist in a stable state in the formulation.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the terminology used herein is for the purpose of describing the invention, and is in no way intended to limit the scope of the invention. It is not used for. Therefore, those skilled in the art will appreciate that various modifications and equivalent arrangements may be made therein without departing from the scope of the present invention.

Claims (3)

A mixture of 2.00% by weight of arbutin, 1.50% by weight of polyglutamic acid, 1.50% by weight of ethanol, 1.00% by weight of glycerin, 1,2-butanediol, 1.00% by weight of hexanediol, 0.60% by weight of hydrogenated castor oil, 0.50% by weight of hydrolized elastin, 0.10% by weight of betaine, 0.10% by weight of green tea extract, 0.10% , 0.01% by weight of caprylic / capric triglyceride, 0.01% by weight of isetil hexapeptide-8, 0.1% by weight of glycerol, 0.1% by weight of glycerin, 0.05% by weight of flavor, 0.04% by weight of adenosine, 0.034% by weight of caramel, 0.0200014% 0.001% by weight of glycerin, 0.007% by weight of reel polymethacrylate, 0.002% by weight of propylene glycol, 0.00003% by weight of soybean oil, 0.00002% by weight of phenoxyethanol, 0.00001% by weight of lecithin, 0.0000012% by weight of sodium ascorbyl phosphate, , Human oligopeptide De -1 0.0000001 skin regeneration consisting of a combination of wt and cosmetic composition for improving skin wrinkles. delete delete

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