KR100843155B1 - Cosmetic Compositions to stabilize Ascorbic acid - Google Patents

Abstract

The present invention relates to a double stabilized vitamin C-containing whitening cosmetic composition,

Specifically, oxyresveratrol was used as an oxidative stabilizer to block the access of active oxygen to vitamin C in aqueous solution, thereby increasing the oxidation stability of vitamin C by blocking access to vitamin C of active oxygen. The stable solution is wrapped in a lecithin-organo gel structure to further stabilize vitamin C to provide an effective whitening cosmetic.

Vitamin C, Oxyresveratrol, Lecithin, Organo Gel, Whitening

Description

Double-stabilized Vitamin C-Containing Skin Whitening Cosmetic Composition {Cosmetic Compositions to stabilize Ascorbic acid}

The present invention relates to a whitening cosmetic composition for stably maintaining unstable vitamin C in water. Specifically, the present invention primarily uses oxyresveratrol as an oxidative stabilizer to block the access of active oxygen to vitamin C in aqueous solution. In order to increase the oxidation stability of vitamin C, the secondary stabilized solution is secondly wrapped in a lecithin-organo gel structure to further stabilize vitamin C to provide an effective whitening cosmetic. A stabilized vitamin C-containing skin whitening cosmetic composition.

The skin, which consists of the epidermis, the dermis, and the subcutaneous fat, is the largest organ that makes up the human body. However, as the skin ages, the function of the skin sharply deteriorates and various changes are aging. The thickness of the skin becomes thinner, the function of the skin barrier sharply deteriorates, so that the moisture content of the skin decreases and the skin dries. Causes various skin lesions. In particular, the production of highly reactive free radicals and free radicals due to the increase in the amount of ultraviolet rays, air pollution, and excessive fatigue and stress of modern people, oxidizes or denatures biological components (proteins, nucleic acids, cell membrane lipids, etc.) It acts as the main cause. Wrinkle formation, skin elasticity reduction and pigmentation due to skin aging have been studied as the most important issues in skin care and cosmetics.

Retinol, a vitamin A that is already widely used in dermatology to improve skin wrinkles, blemishes and pigmentation, is also widely used as a cosmetic agent, and retinol-containing cosmetics can reduce wrinkles, sagging and elasticity caused by sunlight. Effective clinical results have been reported, and US Pat. Nos. 4,603,146 and 4,877,805 have suggested an anti-wrinkle effect using retinol which is effective for collagen synthesis and degradation inhibition. Wrinkle improvement by collagen synthesis is also effective in the cosmetic composition containing L-ascorbic acid (vitamin C), which is effective in anti-oxidation effect and anti-pigmentation, pigmentation such as blemishes, freckles, and black mushrooms, in addition to skin wrinkle improvement. There is a report. (U.S. Patent No. 4,938,969 / U.S. Patent No. 4,772,591 / European Patent No.0533667)

Although the skin is natural aging, wrinkles, elasticity, roughness and dryness, blemishes and freckles occur due to natural aging, especially by photoaging, resulting in a poor cosmetic appearance.

Vitamin C has been applied to food, medical or cosmetics for a long time since it has an excellent effect on suppressing or improving such aging through various physiological functions in vivo.

Looking briefly at the function of vitamin C, vitamin C promotes the activity of the prolyl hydroxylating agent to promote hydroxy proline biosynthesis, thereby promoting collagen biosynthesis, a triple helix structure, thereby improving skin wrinkles. Vitamin C is highly resistant to UVA and reduces erythema and edema caused by UVB. Vitamin C also acts as a powerful bio-oxidant in skin, blood and other tissues. It prevents the oxidation and degeneration of biological components by highly reactive free radicals, free radicals, and peroxides. Have In addition, vitamin C has a pigmentation inhibitory effect, because it has a melanin pigmentation inhibitory effect.

However, vitamin C, which has various effects like this, is very unstable in heat, light, oxygen, etc., so it is exposed to the atmosphere or easily oxidized in aqueous solution, which lowers its titer, discoloration, and odor. Derivatives have been studied and used, but they also have inferior problems with pure vitamin C in terms of efficiency.

Recently, vitamin C has a variety of unstable problems, but also has a number of physiological functions have been studied in various forms to stabilize the unstable vitamin C.

For example, they used chemical techniques to make chemical associations with gluconic or uronic acids or to incorporate them into cyclodextrins, geolites, liposomes, and the like. As another method, a method of coating vitamin C has been suggested. However, these methods did not show sufficient stability in terms of efficiency, and in some cases were not suitable for cosmetic formulations.

On the other hand, a study to stabilize by introducing various antioxidants, including vitamin E, was attempted, but problems such as odor and discoloration could not be solved. (US Patent No. 4938969)

Therefore, the present inventors conducted a study to solve the stability problem of vitamin C, using a powerful antioxidant to increase the oxidative stability of vitamin C in the formulation, and by collecting vitamin C in the lecithin organogel formulation By increasing the amount of bound water, vitamin C could be effectively stabilized by reducing the ion activity of vitamin C.

Accordingly, an object of the present invention is to provide a stabilized vitamin C-containing whitening cosmetic composition.

Specific solution means for achieving the above object of the present invention,

[Oxyresveratrol is used as an oxidative stabilizer to block the access of active oxygen to vitamin C in aqueous solution to block the access to vitamin C of active oxygen to increase the oxidative stability of vitamin C. Wrapped with lecithin)-organo gel structure lecithin gel,

The vitamin C is 0.1 to 20% compared to 100% of the total composition, oxyresveratrol is made of 0.05 to 10%,

The lecithin gel is dissolved in 5g of vitamin C and 15g of water in a solution in which 6g of phosphatidylcholine (Lipoid S100-3), 10g of ethanol, 10g of MCT (Medium chain triglyceride), 54.0g of PG (Propyleneglycol), and 2.0g of oxyresveratrol are dissolved. A total of 20 g of water, stirred at room temperature,

The cosmetic composition is one having a formulation selected from the group consisting of supple cosmetics, astringent cosmetics, nourishing cosmetics, eye cream, nutrition cream, massage cream, cleansing cream, cleansing foam, cleansing water, packs, essences] The above object can be achieved by the constitutional features.

In order to achieve the above object, an antioxidant according to the present invention used oxyresveratrol. Oxyresveratrol is a much more potent antioxidant than commonly known resveratrol. Oxyresveratrol, on the other hand, strongly inhibits tyrosinase, which is involved in the formation of melanin, and when used in conjunction with vitamin C, synergistic effects on skin whitening can be expected.

Organogels are typically known as gelatin gels and lecithin gels. These gels consist of a water / oil microemulsion (water in oil) system, which is the optimal system to stabilize the water-soluble vitamin C in the gel. In this study, lecithin gels were used, and properly formulated vitamin C-containing lecithin gels have a skin-like structure that reduces the presence of free water and increases the amount of bound water in the preparation, thus reducing the ion activity of vitamin C. In addition, oxidative stability of vitamin C is increased by blocking free radicals from accessing vitamin C.

On the other hand, when applied to whitening cosmetics using vitamin C-containing lecithin gel, the oxidation stability of vitamin c was improved by blocking the access of active oxygen in water, and the whitening effect was also excellent. For the following examples, prescription examples, comparative examples and experimental examples will be described in detail the configuration and effect of the present invention. However, the present invention is not limited to these.

EXAMPLES Making Lecithin Gels with Stabilized Vitamin C

A total of 20g of vitamin C and 15g of water dissolved in 6g of phosphatidylcholine (Lipoid S100-3), 10g of ethanol, 10g of medium chain triglyceride (MCT), 54.0g of PG (Propyleneglycol), and 2.0g of oxyresveratrol Water was added and stirred at room temperature to make lecithin gels.

Prescription Example 1. A prescription example of a nourishing cream containing lecithin gel (Example 1) is as follows.

ingredient Content (weight%) Lecithin gel 20.0 Camellia oil 3.0 Stearyl alcohol 1.5 Stearic acid 1.5 Glyceryl Stearate 1.5 Liquid paraffin 10.0 Beeswax 2.0 Polysorbate 2.5 Sorbitan 0.5 Squalane 3.0 1,3-B.G 3.0 glycerin 5.0 Triethanol amine 0.5 Tocopheryl Acetate 0.5 Mountain Mulberry Extract 2.0 Preservative, pigment Quantity incense Quantity Purified water Remaining amount Sum 100

Comparative Example 1.

Composition prepared according to Formulation Example 1) with vitamin C not stabilized in place of lecithin gel

ingredient Content (weight%) Vitamin c 20.0 Camellia oil 3.0 Stearyl alcohol 1.5 Stearic acid 1.5 Glyceryl Stearate 1.5 Liquid paraffin 10.0 Beeswax 2.0 Polysorbate 2.5 Sorbitan 0.5 Squalane 3.0 1,3-B.G 3.0 glycerin 5.0 Triethanol amine 0.5 Tocopheryl Acetate 0.5 Mountain Mulberry Extract 2.0 Preservative, pigment Quantity incense Quantity Purified water Remaining amount Sum 100

Experimental Example 1. Measurement of the titer of vitamin C

In Formulation Example 1) and Comparative Example 1), the initial titer of vitamin C in the composition was 100, and the vitamin C titer after one month was measured at 25 ° C and 45 ° C, and the results are shown in Table 1).

    Table 1. Comparison of titers of vitamin C

Example 1 Comparative Example 25 degrees 99 70 45 degree 85 40

As shown in the table, it can be seen that the formulation stabilized with lecithin gel vitamin C (Example 1) is much more stable over time than the formulation (Comparative Example 1).

Experimental Example 2 Measurement of Whitening Effect by Clinical Experiment

1) Method: To test the clinical whitening efficacy of cosmetics of the present invention, 20 healthy men and women with blemishes, freckles and pigmentation were randomly divided into two groups A and B. Prescription Example 1) containing lecithin gel stabilized with vitamin C was applied to Group A, and Comparative Example 1) was applied to Group B, twice a day for 12 weeks. The change of brightness (ΔL) of color was measured, and objective parenting observation by a plurality of skilled workers and subjective visual observation by a subject were measured, and effects were measured according to the following classification. The results are shown in Table 2). At this time, the degree of whitening efficacy was classified into the following seven ratings.

Evaluation criteria for whitening efficacy: -3: Very aggravated, -2: Aggravated, -1: Slightly worsened, 0: No change, 1: Slightly improved, 2: Improved, 3: Very improved

2) Experiment result

Table 2. Clinical Results for Whitening Effects

 Subject Skin color change (ΔL) Objective evaluation of the skilled person Subjective Evaluation of Subject A B A B A B One 7.2 4.9 3 One 3 2 2 6.9 5.1 3 2 2 3 3 7.7 4.8 3 3 3 3 4 7.3 4.1 2 2 2 One 5 8.0 4.9 3 2 3 One 6 7.5 5.4 3 2 2 One 7 8.8 5.2 3 One 3 0 8 6.7 4.8 3 3 3 2 9 7.4 5.9 3 2 3 3 10 8.7 5.6 2 One 3 3 medium 7.62 5.07 2.9 1.9 2.7 2.0

As shown in Table 2), it can be seen that the group A applied the product of the vitamin C stabilized formulation of the present invention has excellent whitening clinical effect in all three evaluations compared to the group B applied to the product not applied.

According to the present invention, by stabilizing vitamin C as oxyresveratol and lecithin gel, it is possible to significantly improve the oxidative stability of vitamin C in the product and to provide a composition that can be used for cosmetics and pharmaceuticals as it does not cause discoloration or odor. .

In the above, the present invention has been illustrated and described with reference to specific preferred embodiments, but the present invention is not limited to the above-described embodiments and is not limited to the spirit of the present invention. Various changes and modifications can be made by those who have

Claims (4)

Oxyresveratrol was used as an oxidative stabilizer to block the access of active oxygen to vitamin C in aqueous solution, thereby increasing the oxidation stability of vitamin C by blocking access to vitamin C of active oxygen, and then adding lecithin to the solution. A double-stabilized vitamin C-containing skin whitening cosmetic composition, characterized in that it is wrapped with lecithin gel, which is an organo-gel structure. The method of claim 1, The vitamin C is 0.1 to 20% compared to 100% of the total composition, oxyresveratrol is a double stabilized vitamin C-containing skin whitening cosmetic composition, characterized in that consisting of 0.05 to 10%. The method of claim 1, The lecithin gel is dissolved in 5g of vitamin C and 15g of water in a solution in which 6g of phosphatidylcholine (Lipoid S100-3), 10g of ethanol, 10g of MCT (Medium chain triglyceride), 54.0g of PG (Propyleneglycol), and 2.0g of oxyresveratrol are dissolved. Double stabilized vitamin C-containing skin whitening cosmetic composition, characterized in that it was prepared by adding a total of 20g of water and stirred at room temperature. The method of claim 1, The cosmetic composition is characterized in that it has any one formulation selected from the group consisting of softening cream, astringent makeup, nutrient cream, eye cream, nutrition cream, massage cream, cleansing cream, cleansing foam, cleansing water, pack, essence Double stabilized vitamin C-containing skin whitening cosmetic composition.