KR20180060537A - Whitening functional cosmetic composition having skin-regeneration and moistureizing - Google Patents

Abstract

The present invention relates to a whitening functional cosmetic composition having enhanced skin-regeneration and moisturizing functions, which comprises 1 to 10 wt% of niacinamide, 1 to 5 wt% of polydeoxyribonucleotide, 0.01 to 5 wt% of hyaluronic acid or hyaluronate and the balance consisting of purified water and additives, wherein the composition is excellent in whitening effects by having activity such as pigmentation inhibition, and besides the skin (cell) regeneration effect, shows excellent skin moisturizing effect with excellent moisture retaining ability.

Description

WHITENING FUNCTIONAL COSMETIC COMPOSITION HAVING SKIN-REGENERATION AND MOISTUREIZING BACKGROUND OF THE INVENTION 1. Field of the Invention [0001]

The present invention relates to a whitening functional cosmetic composition having enhanced skin regeneration and moisturizing function, and more particularly to a cosmetic composition containing a niacinamide having a whitening function, a polydeoxyribonucleotide (PDRN) having skin regeneration function, and a hyaluronic acid Or a hyaluronate (Hyaluronate).

The skin is an organ that covers the outside. It protects the internal organs from changes in temperature and humidity, ultraviolet rays, pollutants and external environment. It is composed of epidermis and subcutaneous fat from the outside. Particularly, the epidermis, which determines the nature of the skin, is directly and frequently damaged from the outside, so restoration of the wound is very important. Cells of the basal layer located at the innermost part of the epidermis are divided into stratum corneum as they undergo proliferation and cleavage to maintain the overall bilayer structure, thereby protecting the skin surface from external harmful environments. However, the outer skin cells, which are the outermost parts of the skin, are removed and removed, and cell regeneration, which is the process of replacing cells underneath them, is constantly repeated. When external skin damage occurs, cell regeneration occurs rapidly, Recovery should be promoted. As the age increases, the proliferation of fibroblasts that repair skin damage is reduced, and the synthesis of collagen, which is a connective tissue, is reduced, and the regenerative capacity is lowered. .

In addition, the skin corresponds to the portion having the largest amount of water, and it has moisture and oil at the same time, and the oil has a function of inhibiting the moisture of the skin from being evaporated. Moisture loss of the skin is prevented by the lipid layer which mainly contains the ceramide having the hydrophilic group and the lipophilic group. If the skin is not moisturized, the ability to regenerate the cells will be reduced, the elasticity will decrease, and wrinkles will occur and the skin aging will be promoted.

Therefore, in order to maintain skin's unique function, it is possible to quickly and effectively heal wounds of the skin and promote regeneration. In order to maintain healthier and more beautiful skin, a physiologically active substance obtained from various plants and microorganisms has been added to cosmetics, However, development of cosmetics promoting skin regeneration is actively under way.

Korean Patent Laid-Open No. 10-2008-0082802 relates to a skin-moisturizing cosmetic composition containing anion water. In order to effectively maintain skin moisturization, glycerin, dipropylene glycol, hyaluronic acid and other additives are mixed in anion water And provides a cosmetic composition that moisturizes the skin.

Korean Patent Laid-open Publication No. 10-2015-0092410 entitled " Cosmetic Composition Comprising Ceramide and Natural Extracts and Method for Producing the Same "discloses a method of supplying moisture to skin by containing ceramide, non-leaf extract, .

However, the above-mentioned conventional techniques have disadvantages in that they do not exhibit satisfactory skin regeneration and moisturizing effect, and improvement thereof has been demanded.

Disclosure of Invention Technical Problem [8] Accordingly, the present invention has been made keeping in mind the above problems occurring in the prior art, and an object of the present invention is to provide a functional cosmetic composition having a skin regeneration function, an excellent moisturizing and whitening function.

SUMMARY OF THE INVENTION

1 to 10% by weight of niacinamide, 1 to 5 parts by weight of polydeoxyribonucleotide, 0.01 to 5% by weight of hyaluronic acid or hyaluronate and the balance of purified water and an additive, wherein the skin regenerating and moisturizing function is enhanced, .

Another object of the present invention is to provide

It is intended to provide a composition using the composition according to the present invention in the form of an essence, a mask pack, a nutritional cream, a massage cream, an eye cream, and a cleansing cream.

The present invention will be described in more detail as follows.

The present invention relates to a cosmetic composition comprising 1 to 10% by weight of niacinamide, 1 to 5 parts by weight of polydeoxyribonucleotide, 0.01 to 5% by weight of hyaluronic acid or hyaluronate and the balance of whitening function To provide a cosmetic composition.

Niacin amide, shown below, is a water-soluble vitamin B3 registered in the Food and Drug Administration and is essential for our body and contains many green vegetables and grains. It is well soluble in water and ethanol, and is very stable in heat and light. Niacinamide reduces the movement of melamine to maintain clean skin. It also improves oily skin and promotes collagen secretion by activating skin cells. It helps to improve aging skin and prevents loss of skin moisture. It stimulates the microcirculation of the dermis and strengthens the skin barrier.

The niacinamide according to the present invention is preferably used in an amount of 1 to 10% by weight, and when it is less than 1% by weight, the whitening function required is inferior. When it exceeds 10% by weight, .

[Molecular formula]

The term "whitening " as used in the present invention means whitening the skin, which means excessive synthesis of melanin or alleviation or improvement of spots, freckles and various pigmentation caused by melanin deposition.

In one embodiment according to the present invention, 20 healthy male and female persons were selected, and the mask pack was manufactured using the cosmetic composition according to the present invention. After using the mask pack for a certain period of time, the degree of skin pigmentation was visually observed, As a result, it was evaluated that the effect was excellent in the group using the pack using the cosmetic composition according to the present invention.

In the cosmetic composition according to the present invention, it is preferable that 1 to 5% by weight of polydeoxynucleotide is used for skin cell regeneration. If it is contained in an amount of less than 1% by weight, a whitening effect can not be substantially expected. If it exceeds 5% by weight, the overall processability of the composition is deteriorated.

Polydeoxyribonucleotide (PDRN) is a compound containing a DNA complex, ie, a deoxyribonucleotide polymer, which acts as an activator for cell regeneration without stimulating the A2 puringeric receptor, It promotes cell differentiation such as chondrocytes, and is effective for burns and chronic wounds. It is highly stable because of its high similarity with human genes. It also activates VEGF and activates collagenase, thrombolysis, growth factor promoting action Lt; / RTI >

             [Action of PDRN]

As used herein, the term "regeneration" refers to the process of recovery of skin tissue against damage to the skin or cells caused by skin surgery and internal causes. The damage caused by the external cause may include ultraviolet rays, external contaminants, wound, trauma, and the damage caused by the internal cause may be stress.

According to one embodiment of the present invention, in order to confirm the cell regeneration effect due to the polydeoxyribonucleotide (PDRN), the skin fibroblasts are plated in a culture container to be stabilized, and then the composition according to the present invention is treated As shown in FIG. 1, the composition according to the present invention has an excellent effect on the cell proliferation promoting activity, so that the regeneration of the skin (cell) damaged by external or internal factors, ≪ RTI ID = 0.0 > and / or < / RTI >

In the cosmetic composition according to the present invention, 0.01 to 5% by weight of hyaluronic acid or hyaluronate is preferably used to provide moisturizing. When the content of the hyaluronic acid salt is less than 0.01% by weight, the desired moisturizing effect is difficult to be exhibited. When the content of the hyaluronic acid salt is more than 5% by weight, the processability is poor in constituting the cosmetic composition.

The hyaluronate used in the present invention may be selected from at least one of sodium hyaluronate, potassium hyaluronate, calcium hyaluronate, magnesium hyaluronate, zinc hyaluronate, cobalt hyaluronate and tetrabutylammonium hyaluronate.

As used herein, the term "moisturizing" means maintaining the homeostasis of the skin by appropriately controlling water loss and the like. According to one embodiment of the present invention, the cosmetic composition according to the present invention has excellent water retention have.

Specifically, in one embodiment of the present invention, skin essence containing hyaluronate was prepared, and skin moisture resistance was measured with time after human body experiment. As shown in FIG. 3, as shown in the graph, The composition according to the present invention is suitable for use as a cosmetic composition for moisturizing the skin or as an external preparation for skin, and is excellent in moisturizing the skin.

The cosmetic composition according to the present invention can be manufactured by a conventional method known in the art and can be made into a cosmetic composition, and is not particularly limited for the present invention.

In addition, the composition of the present invention may further include conventional additives which are not harmful to the human body, such as perfumes, vitamins, stabilizers, sulfating agents and the like, in addition to the above components.

The cosmetic composition of the present invention can be formulated into a form prepared by a method customary in the art, for example, essence, gel, cream, lotion, solution, soap, and the like. More specifically, it can be manufactured in formulations such as skins, lotions, nourishing creams, massage creams, essences, eye creams, cleansing creams, packs and the like.

The cosmetic composition according to the present invention has an activity such as inhibition of pigment deposition, thereby not only excelling in whitening effect but also exhibiting excellent skin moisturizing effect due to excellent moisture holding power in addition to skin (cell) regeneration effect.

1 is a photograph showing the degree of cell proliferation for 3 days of the composition of Example 1 and Comparative Example 1 according to the invention,
2 is a graph showing the number of cells after 3 days of culturing the composition of Example 1 and Comparative Example 1 according to the present invention,
FIG. 3 is a graph showing moisture content of the cosmetic composition of Example 1 and Comparative Example 2 according to the present invention measured over time.

Hereinafter, the present invention will be described in more detail with reference to the following examples and experimental examples. However, the following Examples and Experiments are for illustrative purposes only and are not intended to be construed as limiting the present invention.

Example 1: Essence of  Produce

5.0% by weight of ascorbic acid, 0.9% by weight of tranexamic acid, 2.0% by weight of Niacinamide, 1.0% by weight of PDRN, 0.05% by weight of sodium hyaluronate, 4.5% by weight of sodium bicarbonate and 0.02% by weight of disodium EDTA were mixed with purified water to prepare 100% by weight of cell regeneration and moisturizing enhanced whitening cosmetic composition.

Comparative Example  One : PDRN  Manufacture of unripe essence

5.0 wt% of ascorbic acid, 0.9 wt% of tranexamic acid, 1.0 wt% of PBS, 0.05 wt% of sodium hyaluronate, 4.5 wt% of sodium bicarbonate, 0.02% by weight of disodium EDTA was mixed with purified water to prepare a cosmetic composition.

Comparative Example  1: Preparation of Essence without Hyaluronic Acid

5.0 wt% of Ascorbic Acid, 0.9 wt% of Tranexamic Acid, 1.0 wt% of PBS, 4.5 wt% of Sodium Bicarbonate, 0.02 wt of Disodium EDTA % Were mixed with purified water to prepare a cosmetic composition.

Experimental Example  One

To evaluate the cell regeneration effects of the compositions of Example 1 and Comparative Example 1 prepared in Example 1 and Comparative Example 1, skin fibroblasts (CRL 2429) were purchased from Korean Cell Line Bank and cultured in a 10% FBS (Dulbecco ' s Modified Eagle ' s Medium) medium supplemented with Fetal bovine serum was used. The cells were subcultured in a 5% CO ₂ incubator at 37 ° C. CRL 2429 cells were plated in a 60 ml culture vessel with 30,000 cells and then stabilized for 24 hours. After the medium was removed, the composition of Example 1 and Comparative Example 1 was treated and cultured for 3 days, and the degree of cell increase was measured and shown in FIG.

FIG. 1 is a photograph showing morphological results obtained by plating 30,000 dermal fibroblasts on a 60 mm dish and then culturing the composition of Example 1 and Comparative Example 1 for 3 days. As compared with Comparative Example 1 In Example 1, it was confirmed that more cells proliferated.

FIG. 2 is a graph showing the cell counts obtained when the composition of Example 1 and Comparative Example 1 was treated and cultured for 3 days after plating 30,000 dermal fibroblasts on a 60 mm dish. As a result, It was confirmed that the cells of Example 1 proliferated more than twice as compared with Comparative Example 1.

Experimental Example 2: Sensory evaluation

Using the essence prepared in Example 1 and Comparative Example 1, sensory evaluation was carried out to confirm skin pigmentation inhibition effect, that is, whitening effect.

20 healthy male and female subjects were selected and the skin condition of the facial state was checked and recorded before the experiment. Then, the pack using the essence prepared in Example 1 and Comparative Example 1 was prepared, and 20 Min. The degree of pigmentation was visually observed for each of them, and the results were evaluated in two stages, with and without effect, and the results are shown in Table 1 below.

division Effective (persons) No effect (persons) Example 1 17 3 Comparative Example 1 8 12

Experimental Example  3

Skin moisturizing effect tests were conducted to evaluate the moisturizing and strengthening effect of the cosmetic compositions prepared in Example 1 and Comparative Example 2. [ MY-808S Moisture Checker (Scalar, Japan) was used for the skin moisturizing effect, and the experiment was performed using the inside of the arm. The measurement was carried out in a constant temperature and humidity chamber controlled at a constant temperature of 20 ° C and a humidity of 60% and 0.5 g / cm 2 of the composition of Example 1 and Comparative Example 1 was applied to the inside of the arm. Hour, and the skin moisturizing power after 4 hours had passed.

As shown in FIG. 3, the moisture content of Comparative Example 2 was 32% when the essence was applied to the skin according to Example 1 and Comparative Example 2, and the moisture content of Example 1 was 38.4 %. As a result, it was confirmed that the moisture content of the skin after 4 hours was higher than that of Comparative Example 2, and that the skin moisturizing power of Example 1 was maintained higher than that of Comparative Example 2.

Claims (7)

Characterized in that it comprises 1 to 10% by weight of niacinamide, 1 to 5% by weight of polydeoxyribonucleotide, 0.01 to 5% by weight of hyaluronic acid or hyaluronate and the balance of purified water. A cosmetic composition.
The method according to claim 1,
Wherein the hyaluronic acid is pure hyaluronic acid or hyaluronate, and the hyaluronate is an inorganic salt such as sodium hyaluronate, potassium hyaluronate, calcium hyaluronate, magnesium hyaluronate, zinc hyaluronate, cobalt hyaluronate, etc. and tetrabutyl hyaluronate And an organic salt such as ammonium, etc. The skin-care cosmetic composition of the present invention has enhanced skin regeneration and moisturizing function.
3. The method according to claim 1 or 2,
Wherein the hyaluronic acid or the hyaluronic acid salt has a molecular weight of 500 kDa to 6,000 kDa, which enhances skin regeneration and moisturizing function.
The method according to claim 1,
Wherein the cosmetic composition has enhanced skin regeneration and moisturizing function, characterized by inhibiting melanin synthesis, regenerating skin by cell proliferation activity, and retaining moisture.
The method according to claim 1,
The cosmetic composition may be prepared in the form of a skin, a lotion, a nutritional cream, a massage cream, an essence, an eye cream, a cleansing cream, a cleansing foam, a mask pack, Composition.
The method according to claim 1,
Wherein the cosmetic composition is characterized in that at least one selected from an antioxidant, a solubilizer, a vitamin, a pigment, and a perfume can be further added.
The method according to claim 1,
Wherein the cosmetic composition is prepared in the form of a paste, a cream, a gel, a powder, a spray, an emulsion or a suspension.

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