KR20070118719A - Skin topical composition containing epidermal growth factor and fibroblast growth factor - Google Patents

Skin topical composition containing epidermal growth factor and fibroblast growth factor Download PDF

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KR20070118719A
KR20070118719A KR1020060052786A KR20060052786A KR20070118719A KR 20070118719 A KR20070118719 A KR 20070118719A KR 1020060052786 A KR1020060052786 A KR 1020060052786A KR 20060052786 A KR20060052786 A KR 20060052786A KR 20070118719 A KR20070118719 A KR 20070118719A
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skin
growth factor
fibroblast growth
epidermal growth
cosmetic
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KR1020060052786A
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Korean (ko)
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박희준
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주식회사 씨에이팜
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Publication of KR20070118719A publication Critical patent/KR20070118719A/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A61K8/355—Quinones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Emergency Medicine (AREA)
  • Cosmetics (AREA)

Abstract

A skin topical composition comprising an epidermal growth factor and a fibroblast growth factor is provided to improve effects of skin whitening, melanin formation inhibition, skin moisturizing, skin wrinkle improvement and stretch mark and oxidation inhibition by optimizing the mixing ratio of effective ingredients. A skin topical composition for improving skin beauty comprises 0.01-1 ppm of epidermal growth factor, 0.01-1 ppm of fibroblast growth factor, 1.0-5.0 wt.% of amino acid peptide, 0.1-2.0 wt.% of glabridin, 0.1-3.0 wt.% of ubiquinone(coenzyme Q10) and 0.1-2.0 wt.% of vegetable collagen(extension N-200), and has a formulation selected from cosmetic lotion, cream, ointment, emulsion, foundation, oil, pack, soap, body soap, lipstick, nail cosmetic, eye cosmetic, perfume, washing cosmetic, toothpaste, mouth wash, deodorizer, bath agent, shampoo, rinse, hair tonic, hair spray or hair dye.

Description

상피세포성장인자 및 섬유아세포성장인자를 함유하는 피부 도포용 조성물{Skin topical composition containing epidermal growth factor and fibroblast growth factor}Skin topical composition containing epidermal growth factor and fibroblast growth factor

본 발명은 상피세포성장인자 및 섬유아세포성장인자를 함유하는 피부 도포용 조성물에 관한 것으로서, 보다 구체적으로는 상피세포성장인자(Epidermal growth factor), 섬유아세포성장인자(Fibroblast growth factor), 아미노산 펩타이드, 글라브리딘(Glabridin), 유비퀴논(Coenzyme Q 10) 및 식물성 콜라겐(Extensin N-200)을 포함하는 피부 도포용 조성물에 관한 것이다.The present invention relates to a composition for skin application containing epidermal growth factor and fibroblast growth factor, and more specifically, epidermal growth factor, fibroblast growth factor, fibroblast growth factor, amino acid peptide, It relates to a composition for skin application comprising Glabridin, ubiquinone (Coenzyme Q 10) and vegetable collagen (Extensin N-200).

노화란 곧 늙는다는 것을 의미한다. 의학적인 면에서 살펴보면, 노화란 세월이 감에 따라 신체의 모든 생리적 변화가 발생, 현저한 퇴화현상이 나타나게 되는 것이다. 여성호르몬, 남성호르몬, 성장호르몬 등의 활성이 저하되어 근육의 질량은 줄어드는 반면, 지방과 수분은 오히려 증가되어 운동력이 떨어지게 된다. 피부, 근육, 뼈, 폐, 혈관 등에 분포하는 콜라겐과 엘라스틴도 새로운 합성이 감소되고 이미 생성된 물질들마저 제 기능을 못하게 된다. 따라서 피부의 탄력성이 없어지고 주름이 지는가 하면, 뼈가 쉽게 부러지고 폐와 혈관벽이 탄력을 잃어 혈압이 높아 지고 심장이 약해진다. 또 눈이 나빠지고 청취능력이 저하되며 식욕이 떨어진다. 대뇌피질의 세포감소로 인한 기억력 저하로, 특히 최근에 일어난 일들을 잘 기억하지 못하며 근육이 약해지고 지방과 수분의 양이 많아져 허약한 체질이 된다.Aging means getting old. In medical terms, aging means that all physiological changes in the body occur over time, resulting in significant degeneration. Female hormones, male hormones, growth hormones, such as activity is reduced to decrease the mass of the muscle, while fat and water is rather increased and the movement is reduced. Collagen and elastin in the skin, muscles, bones, lungs, and blood vessels also reduce new synthesis, and even the already produced substances do not function. Therefore, the elasticity of the skin is lost and wrinkles, the bones are easily broken, the lung and blood vessel walls lose elasticity, blood pressure increases and the heart is weak. In addition, eyes are bad, listening ability is reduced, and appetite is reduced. Memory loss due to cerebral cortex decreases, especially the recent events do not remember well, weak muscles and a lot of fat and water is a weak constitution.

노화란 단순히 젊음과 성숙도가 약해져 간다는 의미라기보다 외부로부터의 악영향이나 질병 등 신체의 외상시 대응하는 기관이나 조직의 기능이 저하되어 있다는 것이다.Aging does not mean that the youth and maturity are weakened, but the function of organs or tissues that respond to trauma to the body, such as adverse effects or diseases from the outside, is reduced.

이중 우리가 가장 현실적으로 빨리 느낄 수 있는 것이 피부이다. 그러나 많은 의견이 분분함에도 아직까지 노화에 대한 정확한 원인은 규명되지 않고 있다. 개인의 조직이나 기관의 노화 정도를 측정하여 앞으로 얼마나 더 살 수 있는지의 추정은 가능하나 결론을 내리기는 힘들다. 왜냐하면 사람마다 노화의 속도가 각기 다르기 때문이다. 즉, 노화란 극히 개인적인 문제이기에 젊은 사람도 나이 들어 보이는 경우가 허다하며 나이가 들어도 젊은이 못지 않게 활기차고 젊게 보여 나이테를 짐작하지 못하는 수가 많다.The skin we can feel the most realistic quickly. However, despite many opinions, the exact cause of aging has not yet been identified. It is possible to estimate how old you can live by measuring the degree of aging of an individual's tissues or organs, but it is difficult to draw conclusions. Because different people have different rates of aging. In other words, aging is an extremely personal problem, so young people often look older and older than young people.

피부는 우리 몸 전체 부피의 약 16％를 차지하고 외부환경과 직접 접해 있으면서, 몸 안으로 침입하려는 치명적인 많은 다양한 유해인자들로부터 우리 몸을 보호하는 중요한 보호막의 역할을 담당하고 있다.The skin occupies about 16% of our body's volume and is in direct contact with the external environment, acting as an important barrier to protecting our body from the many deadly harmful agents that try to break into it.

원래, 건강한 피부에는 이러한 외부 손상 요인들로부터 피부를 보호하는 방어계가 구축되어 있다. 그러나, 인간의 피부는 나이가 들어감에 따라, 각종 오염물질과 스트레스 등으로 인해 손상을 입게 되고 세포 증식이 제대로 이루어지지 않게 되어 피부는 탄력을 잃고 주름이 생기게 된다. 또한, 지속적인 외부 자극에 의해 이러한 방어계는 무너지게 되고, 이에 따라 피부가 보호능을 잃게 되며 세포 보호 및 증식 능력이 떨어지면서, 피부 탄력성 감소와 주름 생성 등 피부 노화 현상이 나타난다.Originally, healthy skin has a built-in defense system that protects the skin from these external damaging factors. However, as human skin ages, it is damaged by various contaminants and stress, and cell proliferation is not properly performed, and the skin loses its elasticity and wrinkles. In addition, due to continuous external stimulation, such a defense system is destroyed, and thus, the skin loses its protective ability, cell protection and proliferation ability decreases, and skin aging such as decreased skin elasticity and wrinkle formation occurs.

한편, 이제까지 우리는 피부 노화가 단지 나이라는 어쩔 수 없는 현상이라고만 생각한 채 체념해 왔다. 그러나 피부 노화의 주된 요인은 가는 세월이 아니라 햇빛 때문이다. 아무리 비싸고 질 좋은 화장품 및 치료약이라 할지라도 예방만큼 좋은 것은 없다. 이제부터라도 가급적 자외선에 노출을 피하고 모든 수단을 동원해 자외선으로부터 피부를 보호해 주면 십 년 후에도 지금과 같은 외모를 지닐 수 있다. 자신의 피부에 맞는 화장품과 약제를 선택하여 피부 관리와 치료를 게을리하지 않는 것이 가장 최선책이다. 의학의 눈부신 발전으로 인간의 평균 수명이 120년을 바라보는 이때, 나이에 걸맞게 살아가기 위해서는 평소 피부 관리에 좀더 신경을 쓰는 습관이 요구된다.In the meantime, we have stayed with the idea that skin aging is just an inevitable phenomenon of age. But the main factor in skin aging is not the age, but the sunlight. No matter how expensive and quality cosmetics and medicines, nothing is as good as prevention. From now on, if possible, avoid exposure to UV rays and use all the means to protect your skin from UV rays. It is best not to neglect your skin care and treatment by choosing the right cosmetics and medications for your skin. When the average life expectancy of human beings is 120 years due to the remarkable development of medicine, it is necessary to pay more attention to skin care in order to live with age.

이렇듯 인간의 피부는 노화 또는 외부적인 충격에 의하여 손상되기 쉬운 단점이 있기 때문에, 이를 보호하고 아름다움을 추구하기 위하여 인류는 오래전부터 화장품을 사용해 왔다.Since human skin has a disadvantage of being damaged by aging or external shock, human beings have used cosmetics for a long time to protect it and pursue beauty.

종래의 기능성 화장품으로는 특히, 노화 및 자외선 노출 등에 의해 생기는 피부의 주름, 처짐을 개선하기 위한 기능성 화장품으로는 비타민 A나 대두추출물, 해조추출물 등의 세포부활제가 사용된 바 있으며, 선행 특허 문헌으로는 대한민국 특허공개 제2003-641호, 제2002-63877호 등이 있었다.In the conventional functional cosmetics, in particular, functional cosmetics for improving wrinkles and sagging of the skin caused by aging and UV exposure have been used, such as vitamin A, soybean extracts, seaweed extracts, etc. Korean Patent Publication Nos. 2003-641 and 2002-63877.

한편, 상피세포성장인자 및/또는 섬유아세포성장인자를 이용한 선행 특허로 서 한국 등록특허 제539431호에서는 수분, 친수성 보습제 및 나노좀화된 표피 세포 성장인자를 함유하는 입술 탄력효과 향상용 입술용 화장료 조성물을 개시하고 있으나, 피부의 균형적인 노화를 방지하기에는 유효 성분이 부족한 단점이 있다.Meanwhile, as a prior patent using epidermal growth factor and / or fibroblast growth factor, Korean Patent No. 539431 describes a lip cosmetic composition for improving the elasticity of the lips containing water, a hydrophilic humectant, and a nanosomalized epidermal growth factor. It discloses, but there is a disadvantage that the active ingredient is insufficient to prevent balanced aging of the skin.

이에 본 발명에서는 미백 및 노화 방지의 기능을 가진 피부 외용제 및 화장료의 유효성분으로서 사용할 수 있는 성분에 대해서 끊임없는 연구를 한 결과, 상피세포성장인자, 섬유아세포성장인자, 아미노산 펩타이드, 글라브리딘(Glabridin), 유비퀴논 및 식물성 콜라겐을 포함하는 피부 도포용 조성물을 피부에 도포할 경우, 미백, 높은 멜라닌 생성 억제, 보습, 주름 억제, 튼살 방지 및 항산화 등의 작용이 우수함을 발견하였고, 이를 기초로 본 발명을 제공하게 되었다.Therefore, in the present invention, as a result of continuous research on the ingredients that can be used as an active ingredient in skin external preparations and cosmetics having the function of whitening and anti-aging, epithelial growth factor, fibroblast growth factor, amino acid peptide, glabridine ( When applying the composition for skin application containing Glabridin), ubiquinone and vegetable collagen to the skin, it has been found to have excellent effects such as whitening, high melanin production suppression, moisturizing, anti wrinkle, stretch marks and antioxidant. The present invention has been made.

따라서, 본 발명의 목적은 피부의 균형적인 노화를 방지하기에 적합한 유효 성분을 잘 조합시킨 상피세포성장인자 및 섬유아세포성장인자를 함유하는 피부 도포용 조성물을 제공하는 데 있다.Accordingly, it is an object of the present invention to provide a composition for skin application containing epidermal growth factor and fibroblast growth factor well combined with active ingredients suitable for preventing balanced aging of the skin.

상기 목적을 달성하기 위한 본 발명의 상피세포성장인자 및 섬유아세포성장인자를 함유하는 피부 도포용 조성물은 상피세포성장인자(Epidermal growth factor) 0.01~1ppm, 섬유아세포성장인자(Fibroblast growth factor) 0.01~1ppm, 아미노산 펩타이드 1.0~5.0중량％, 글라브리딘(Glabridin) 0.1~2.0중량％, 유비퀴논(Coenzyme Q 10) 0.1~3.0중량％ 및 식물성 콜라겐(Extensin N-200) 0.1~2.0중량％을 포함한다.Skin coating composition containing the epidermal growth factor and fibroblast growth factor of the present invention for achieving the above object is epidermal growth factor (Epidermal growth factor) 0.01 ~ 1ppm, Fibroblast growth factor (Fibroblast growth factor) 0.01 ~ 1 ppm, amino acid peptide 1.0 to 5.0% by weight, glabridin 0.1 to 2.0% by weight, 0.1 to 3.0% by weight of ubiquinone (Coenzyme Q 10) and 0.1 to 2.0% by weight of vegetable collagen (Extensin N-200) do.

이하, 본 발명을 보다 구체적으로 설명한다.Hereinafter, the present invention will be described in more detail.

일반적으로, 건강한 정상 피부는 28일 주기로 새로 생겨난다. 사람의 피부는 자외선, 건조, 노화 등에 의해 손상을 받으면 피부의 재생능력이 저하되어 여러가지 트러블이 생긴다. 피부는 위층으로부터 표피, 진피, 피하조직이라는 3가지 층으로 되어 있다. 이중 피부의 아름다움에 깊이 관여하고 있는 것은 표피와 진피이다. 주름을 방지하기 위해서는 활성산소를 발생시키는 자외선을 피하는 것이 첫째이다.In general, healthy normal skin is newly formed every 28 days. When human skin is damaged by UV rays, drying, or aging, the skin's ability to regenerate decreases, causing various problems. The skin has three layers from the upper layer: epidermis, dermis and subcutaneous tissue. Deeply involved in the beauty of the skin is the epidermis and dermis. To prevent wrinkles, the first thing to do is to avoid UV rays that generate free radicals.

한편, EGF(상피세포증식인자)나 FGF(섬유아세포증식인자)가 피부의 상피세포인 케라틴 세포의 세포분열을 촉진시켜 피부의 턴오버를 촉진, 부드럽고 촉촉한 피부를 만들 수 있다. 그리고 섬유아세포증식인자가 피부에 있는 섬유아세포에 자극을 주면 섬유아세포는 활발히 세포분열을 하여 콜라겐이나 엘라스틴, 하이아루론산을 만든다. 콜라겐이나 엘라스틴은 진피의 거의 대부분을 차지하는 섬유 상의 단백질이며 피부 탄력을 관장한다. 콜라겐과 엘라스틴은 완전한 그물 구조로 되어 있으며, 이 두 개의 섬유와 섬유 사이는 하이아루론산 등에 의해 수분이 충분히 공급되므로 피부의 수분양이 증가하여 피부를 탄력 있는 상태로 회복시킨다. 그리고 항산화 작용을 통해서 노화의 원인이 되는 활성산소를 제거함으로써 피부의 노화를 예방할 수 있다. 이와 같이, 세포성장인자 및 항산화 물질의 작용으로 피부의 세포분열 능력을 높이고 피부의 촉촉함과 탄력을 가져오며 주름이나 튼살 등의 피부를 개선시킨다.On the other hand, EGF (Epithelial Proliferation Factor) or FGF (Fibroblast Proliferation Factor) promotes cell division of keratinocytes, which are epithelial cells of the skin, thereby promoting turnover of the skin and making the skin soft and moist. When fibroblast proliferation factor stimulates fibroblasts on the skin, fibroblasts actively divide and produce collagen, elastin, and hyaluronic acid. Collagen or elastin are fibrous proteins that make up the vast majority of the dermis and are responsible for skin elasticity. Collagen and elastin have a perfect net structure, and the two fibers and fibers are supplied with sufficient moisture by hyaluronic acid, thereby increasing the amount of moisture in the skin and restoring the skin to an elastic state. And antioxidants can prevent the aging of the skin by removing the free radicals that cause aging. Thus, by the action of cell growth factors and antioxidants to increase the cell division capacity of the skin, bring the skin moist and elasticity and improve the skin such as wrinkles and stretch marks.

이러한 관점에서 본 발명의 조성물은 상피세포성장인자, 섬유아세포성장인자, 아미노산 펩타이드, 글라브리딘(Glabridin), 유비퀴논 및 식물성 콜라겐을 포 함한다.In this respect, the composition of the present invention includes epidermal growth factor, fibroblast growth factor, amino acid peptide, glabridin, ubiquinone and vegetable collagen.

상기 상피세포성장인자(Epidermal growth factor)는 피부세포신생 및 재생에 핵심적인 역할을 담당한다. 피부의 상피세포성장을 촉진하여 각질세포의 턴오버(Turn over)를 단축시켜서 피부장벽기능 강화작용을 한다. 상기 상피세포성장인자의 사용량은 전체 조성물에 대하여 0.01~1ppm이 바람직하다.The epidermal growth factor plays a key role in skin cell angiogenesis and regeneration. The epidermal growth of the skin is promoted to shorten the turnover of keratinocytes to enhance skin barrier function. The amount of the epidermal growth factor used is preferably 0.01 to 1 ppm relative to the total composition.

상기 섬유아세포성장인자(Fibroblast growth factor)는 진피층에 있는 콜라겐, 엘라스틴의 생합성을 촉진하여 튼살의 발생을 막아주며 진행되고 있는 튼살을 개선하는 작용이 있다. 아울러, 피부세포의 혈관신생을 촉진하여 피부영양과 탄력을 강화한다. 상기 섬유아세포성장인자의 사용량은 전체 조성물에 대하여 0.01~1ppm이 바람직하다.The fibroblast growth factor promotes the biosynthesis of collagen and elastin in the dermal layer to prevent the development of stretch marks and to improve the progress of stretch marks. In addition, it promotes angiogenesis of skin cells to strengthen skin nutrition and elasticity. The amount of the fibroblast growth factor is preferably 0.01 to 1 ppm relative to the total composition.

한편, 상기 아미노산 펩타이드는 과잉의 멜라닌 색소의 생성을 억제하여, 희고 촉촉한 피부를 만들게 하는 작용을 한다. 또한, 아미노산 펩타이드는 잔주름을 억제하고, 콜라겐의 재생을 촉진하며, 활성 산소의 생성을 억제시키는 작용을 한다. 상기 아미노산 펩타이드의 사용량은 전체 조성물에 대하여 1.0~5.0중량％가 바람직하다.On the other hand, the amino acid peptide acts to suppress the production of excess melanin pigment, to make the skin white and moist. In addition, the amino acid peptide functions to inhibit fine wrinkles, promote the regeneration of collagen, and inhibit the production of free radicals. As for the usage-amount of the said amino acid peptide, 1.0-5.0 weight% is preferable with respect to the whole composition.

상기 글라브리딘(Glabridin)은 미백작용이 강력하여 피부의 색소침착을 억제하는 작용을 한다. 상기 글라브리딘의 사용량은 전체 조성물에 대하여 0.1~2.0중량％가 바람직하다.The glabridin has a strong whitening effect to inhibit pigmentation of the skin. As for the usage-amount of the said glabridine, 0.1-2.0 weight% is preferable with respect to the whole composition.

본 발명에 있어서, 보조효소인 유비퀴논(coenzyme Q 10)은 세균에서 포유동물에 이르는 생물 유기체에 널리 분포된 생리학적 필수 요소로서, 생물 유기체의 세포 내 미토콘드리아성 전자 전달계의 구성 성분으로서, 생체 내에서의 반복적인 산화 및 환원반응을 관여하며, 강력한 항산화 및 미백 작용을 하며, 전자 전달에 있어 담체 성분으로 작용하는 천연 물질이다.In the present invention, the coenzyme ubiquinone (coenzyme Q 10) is a physiological essential element widely distributed in biological organisms from bacteria to mammals, and is a component of the mitochondrial electron transport system in cells of biological organisms. It is a natural substance that is involved in repetitive oxidation and reduction reactions in, has strong antioxidant and whitening action and acts as a carrier component in electron transfer.

상기 유비퀴논의 함량은 전체 조성물에 대하여 0.1~3.0중량％가 바람직한데, 유비퀴논의 함량이 0.1중량％ 보다 적을 경우에는 유비퀴논 첨가에 의한 상기 효과가 미약하다는 문제가 있고, 3.0중량％를 초과하면 침전물이 발생할 문제가 있다.The content of the ubiquinone is preferably 0.1 to 3.0% by weight based on the total composition. When the content of the ubiquinone is less than 0.1% by weight, there is a problem in that the effect of the addition of ubiquinone is insignificant, exceeding 3.0% by weight. There is a problem that a precipitate occurs.

상기 식물성 콜라겐(Extensin N-200)은 피부보습과 세포신생작용이 있으며, 그 사용량은 0.1~2.0중량％가 바람직하다.The plant collagen (Extensin N-200) has a skin moisturizing and cell angiogenesis, the amount is preferably 0.1 ~ 2.0% by weight.

또한, 본 발명에 따른 성분을 피부 외용제 조성물에 배합한 경우의 제형에 대해서는 임의적으로 통상적인 성분과 방법에 의해 배합하고, 예컨대, 화장수, 크림, 연고, 유액, 파운데이션, 오일, 팩, 비누(약용 비누도 포함함), 보디 비누, 입술 연지, 손톱 화장품, 눈 화장품, 향수, 세안료, 구강용류(치약, 마우스 워시 등), 방취제(액취, 발냄새 등), 목욕 용제, 샴푸, 린스, 헤어 토닉, 헤어 스프레이, 염모료 등의 제형으로 할 수 있다.In addition, about the formulation in case the component which concerns on this invention is mix | blended with the external preparation composition for skin, it mixes arbitrarily by conventional components and methods, For example, a lotion, cream, ointment, emulsion, foundation, oil, a pack, a soap (medical) Soap), body soap, lip balm, nail cosmetics, eye cosmetics, perfume, face wash, oral solvents (toothpaste, mouse wash, etc.), deodorant (liquid, foot odor, etc.), bath solvent, shampoo, rinse, hair Formulations, such as tonics, hair sprays, and hair dyes, may be employed.

아울러, 본 발명에 따른 성분을 배합한 각종 조성물의 형태는 임의로서, 용액형, 크림형, 페이스트형, 겔형, 젤형, 거품형, 고형상 또는 분말형으로서 이용할 수 있다.In addition, the form of the various compositions which mix | blended the component which concerns on this invention can be used as solution form, cream form, paste form, gel form, gel form, foam form, solid form, or powder form arbitrarily.

전술한 바와 같이, 본 발명에 따른 상피세포성장인자 및 섬유아세포성장인자를 함유하는 피부 도포용 조성물은 유효한 생리 활성물질을 균형있게 함유하고 있 어 미백, 항산화, 보습, 튼살 방지 및 주름개선 등에 있어서 효과가 우수하다.As described above, the composition for skin application containing the epidermal growth factor and fibroblast growth factor according to the present invention contains an effective physiologically active substance in a balanced manner in whitening, antioxidant, moisturizing, stretch marks and wrinkle improvement. The effect is excellent.

Claims (1)

피부 도포용 조성물에 있어서,In the composition for skin application, 상피세포성장인자(Epidermal growth factor) 0.01~1ppm, 섬유아세포성장인자(Fibroblast growth factor) 0.01~1ppm, 아미노산 펩타이드 1.0~5.0중량％, 글라브리딘(Glabridin) 0.1~2.0중량％, 유비퀴논(Coenzyme Q 10) 0.1~3.0중량％ 및 식물성 콜라겐(Extensin N-200) 0.1~2.0중량％을 포함하는 것을 특징으로 하는 상피세포성장인자 및 섬유아세포성장인자를 함유하는 피부 도포용 조성물.Epidermal growth factor 0.01 ~ 1ppm, Fibroblast growth factor 0.01 ~ 1ppm, amino acid peptide 1.0 ~ 5.0% by weight, glabridin 0.1 ~ 2.0% by weight, ubiquinone (Coenzyme) Q 10) A skin coating composition containing an epithelial growth factor and a fibroblast growth factor, comprising 0.1 to 3.0% by weight and 0.1 to 2.0% by weight of vegetable collagen (Extensin N-200).
KR1020060052786A 2006-06-13 2006-06-13 Skin topical composition containing epidermal growth factor and fibroblast growth factor KR20070118719A (en)

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009128584A1 (en) * 2008-04-14 2009-10-22 C.A. Pharm Co., Ltd. The composition for the prevention and treatment of striae distensae and atopy
CN105708778A (en) * 2016-02-02 2016-06-29 广州赛莱拉干细胞科技股份有限公司 Skin care composition, skin cream and preparation method thereof of skin cream
KR20180062756A (en) * 2016-12-01 2018-06-11 (주)골드파파스 Anti-aging and anti-wrinkle cosmetic composition
CN110151595A (en) * 2019-06-25 2019-08-23 天津盛世永业科技发展有限公司 The high efficiency composition system for preventing and treating striae of pregnancy and its application in cosmetics
KR102047808B1 (en) 2019-05-10 2019-11-22 (주)이노진 Composition for regenerating skin or improving wrinkle containing the combination of specific growth factors as active ingredients
KR20200097058A (en) * 2019-02-07 2020-08-18 오성음 Cosmetic composition for anti-aging or anti-wrinkle comprising epidermal growth factor, sericin, Foeniculum vulgare extract and Eugenia caryophyllus extract

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009128584A1 (en) * 2008-04-14 2009-10-22 C.A. Pharm Co., Ltd. The composition for the prevention and treatment of striae distensae and atopy
CN105708778A (en) * 2016-02-02 2016-06-29 广州赛莱拉干细胞科技股份有限公司 Skin care composition, skin cream and preparation method thereof of skin cream
KR20180062756A (en) * 2016-12-01 2018-06-11 (주)골드파파스 Anti-aging and anti-wrinkle cosmetic composition
KR20200097058A (en) * 2019-02-07 2020-08-18 오성음 Cosmetic composition for anti-aging or anti-wrinkle comprising epidermal growth factor, sericin, Foeniculum vulgare extract and Eugenia caryophyllus extract
KR102047808B1 (en) 2019-05-10 2019-11-22 (주)이노진 Composition for regenerating skin or improving wrinkle containing the combination of specific growth factors as active ingredients
CN110151595A (en) * 2019-06-25 2019-08-23 天津盛世永业科技发展有限公司 The high efficiency composition system for preventing and treating striae of pregnancy and its application in cosmetics

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