KR101700903B1 - Anti-wrinkle cosmetic composition containing centella asiatica extract, timosaponin, hyaluronic acid, collagen - Google Patents

Abstract

The present invention relates to a cosmetic composition comprising a Centella asiatica extract, timosaponin, hyaluronic acid, and collagen for alleviating skin wrinkles. More particularly, the present invention relates to a cosmetic composition comprising a Centella asiatica extract, timosaponin, hyaluronic acid, and collagen for alleviating skin wrinkles, which exhibits an increase effect of alleviating skin wrinkles and promoting elasticity of skin. The active components of the cosmetic composition, a Centella asiatica extract, timosaponin, hyaluronic acid, and collagen have a synergic effect in reducing the depth of skin wrinkles and increasing elasticity of skin, thereby remarkably increasing an effect of alleviating skin wrinkles and promoting elasticity of skin.

Description

(ANTI-WRINKLE COSMETIC COMPOSITION CONTAINING CENTELLA ASIATICA EXTRACT, TIMOSAPONIN, HYALURONIC ACID, COLLAGEN) containing chimeric extract, timosaponin, hyaluronic acid and collagen,

More particularly, the present invention relates to a cosmetic composition for improving wrinkles comprising centilla sapphire extract, timosaponin, hyaluronic acid and collagen, and more particularly to a cosmetic composition for improving wrinkles and an effect of improving skin elasticity, such as centilla extract, timosaponin, The present invention relates to a cosmetic composition for improving wrinkles containing collagen.

Skin is a membrane that covers the outside of the body. It plays a role of protecting and protecting internal organs and other body organs by performing various physiological functions to protect the body from environmental factors such as external stimuli, obstacles and drying do. Histologically, the skin is cut vertically and observed with a microscope. The epithelium is composed of the epidermis, the connective tissue, the dermis, and the subcutaneous tissue. Each tissue has a specific function and mutual relationship with each other.

The skin takes about 28 days to produce new skin cells and pushes up old cells to the stratum corneum. This is called the cell turn-over cycle. As the age of women becomes 25 years old or older, the cell regeneration cycle is prolonged for various reasons, causing skin troubles, aging of the skin as the skin becomes dull, water retention decreases, and roughness increases. Particularly, during the season of change, cold and dry winds can cause the skin to lose a lot of moisture and become rough and dry. In addition, the metabolism slows down and the secretion of sweat and sebum sharply decreases, so the skin becomes more dry and unnecessary keratin on the skin surface is increased and dried.

As a result of such a complex cause, the stratum corneum becomes thicker, the skin becomes rough, and the fine wrinkles rapidly increase, especially after 25 years old. At present, interest in skin care is exploding, and there is also a need for cosmetics that can improve such rough skin and fine lines. In particular, there is a demand for an external preparation for skin including a cosmetic composition that has excellent effects of improving the appearance of fine lines and rough skin, and which has been proved to be safe and can be safely used by consumers without any feeling of resistance.

Collagen synthesis promoting substances are frequently used as external preparations for skin, and they are widely used as retinoic acid, transforming growth factor (TGF), animal placenta-derived proteins (Korea Patent Publication No. 2014-0043196), chlorella extract Patent No. 2010-0021566). However, when applied to the skin, the use amount is limited due to safety problems such as irritation and redness, and the effect is insignificant, so that it is difficult to expect substantial skin function improvement effect. Therefore, it is necessary to develop a skin external preparation which is safe to the living body when applied to the skin and has excellent wrinkle-reducing effect.

Korean Patent Publication No. 2014-0043196 Korea Patent Publication No. 2010-0021566

It is an object of the present invention to solve the problems of the prior art as described above. As a result of various combinations of wrinkle-improving substances, it was found that the centilla extract, timosaponin, hyaluronic acid and collagen have synergistic effects And thus completed the present invention.

Accordingly, an object of the present invention is to provide a cosmetic composition for improving skin wrinkles, which comprises centilla callus extract, timosaponin, hyaluronic acid and collagen as an active ingredient.

Another object of the present invention is to provide a cosmetic composition for enhancing skin elasticity comprising centilla extract, timosaponin, hyaluronic acid and collagen as an active ingredient.

In order to achieve the object of the present invention, the present invention provides a cosmetic composition for improving skin wrinkles comprising centilla annulus extract, timosaponin, hyaluronic acid and collagen as an active ingredient.

The chicory extract, timosaponin, hyaluronic acid and collagen may be 0.1 to 10: 0.1 to 10: 0.1 to 10: 0.1 to 10.

The centilla extract may be extracted with at least one extraction solvent selected from the group consisting of water, an anhydrous or a lower alcohol having 1 to 4 carbon atoms, acetone, ethyl acetate, butyl acetate and 1,3-butylene glycol.

The centilla extract, timosaponin, hyaluronic acid and collagen may be contained in an amount of 0.001 to 50.0% by weight based on the total weight of the cosmetic composition.

In order to accomplish still another object of the present invention, the present invention provides a cosmetic composition for enhancing skin elasticity comprising an extract of Centaurea chinensis, timosaponin, hyaluronic acid and collagen as an active ingredient.

The centipede extract, timosaponin, hyaluronic acid and collagen, which are effective components of the cosmetic composition according to the present invention, have a synergistic effect with respect to skin depth and skin elasticity, have.

The present invention provides a cosmetic composition for improving skin wrinkles comprising centilla extract, timosaponin, hyaluronic acid and collagen as an active ingredient.

Also, the present invention provides a cosmetic composition for enhancing skin elasticity comprising centilla extract, timosaponin, hyaluronic acid and collagen as an active ingredient.

Centella asiatica ( Centella asiatica ) is a perennial plant belonging to the family Thunb. It is a perennial herbaceous medicinal plant which lives mainly in South Asia. It grows in Jejudo and southern part of Korea. The major components of the houseplants are madecassoside, madecassic acid, asiaticoside, and asiatic acid. These ingredients have been used in the treatment of skin wounds and chronic ulcers, and have been reported to have good antibacterial properties and also to be effective against skin diseases and antirheumatoid arthritis. In addition, effects such as promotion of cell cycle, proliferation and stimulation of collagen synthesis, and inhibition of skin aging of skin cells have been reported.

As used herein, the term "centromeric extracts" used in the present invention refers to extracts obtained by extracting cinnabarin, a diluted solution or concentrate of the extract, a dried product obtained by drying the extract, a preparation or a purified product of the extract, Extracts themselves and extracts of all formulations which can be formed using extracts. The extract of the present invention can be preferably prepared in the form of a dry powder after extraction.

The extraction solvent of the centilla sp. Extract may be at least one selected from the group consisting of water, an anhydrous or hydrated lower alcohol having 1 to 4 carbon atoms, acetone, ethyl acetate, butyl acetate and 1,3-butylene glycol.

Timothy saponins (Timosaponin) is jimo (Anemarrhena As a material present in the rhizomes of asphodeloides), Sar four sandpaper genin (sarsasapogenin) and a flexible compound, and contains a foamable steroid saponins Marco genin (markogenin) as an aglycone into wide, AI, A-II, A -III , A-IV, BI, and B-II. The type of timosaponin contained in the cosmetic composition according to the present invention may be one selected from the group consisting of AI, A-II, A-III, A-IV, BI, B-II and combinations thereof, May be A-III. Timothy Saponin A-III is represented by the following general formula (1) and may also be referred to as '3-O-β-D-glucopyranosyl- (1 → 2) - β-D-galactopyranosyl'.

≪ Formula 1 >

Hyaluronic acid is a component of polysaccharides present in the extracellular matrix of almost all tissues, maintaining the water content of the tissue, maintaining the extracellular space, and promoting the transport of electrolytes and nutrients (Meyer LJ and Stern R. Dermatol., 102: 385-9, 1994) and has also been shown to promote the migration of fibroblasts and to be effective in depositing collagen fibers and healing wounds (Doillon CJ and Silver FH. Collagen-based wound dressing: effects of hyaluronic acid and fibronectin on wound healing. Biomaterials, 7: 3 1986).

Collagen is a type of protein that exists in skin, bone, cartilage, hair, teeth, digestive tract and blood vessels. It promotes metabolism by filling between cells and cells. It has a very special polymer structure It is a protein. Collagen is responsible for keeping the skin (70% of the dermis) healthy and resilient in the body. In particular, it constitutes 80% of the ligaments and fascia. It connects the bones and muscles like the knee's cruciate ligament and the ankle achilles tendon, and connects the muscles with the ligaments to prevent muscle fibers from spreading. It accounts for 20% of bone and connects between calcium and bone cells. In addition, it occupies 50% of the cartilage, which makes the joints slippery such as knees, elbows and discs. In addition, it is the most important essential protein which occupies more than 30% of the whole protein of our body as the main ingredient of the membrane covering the organs and protects organs by covering various organs with a soft but tough film.

The mixing weight ratio of the centistallophyll extract, timosaponin, hyaluronic acid and collagen, which is an effective ingredient of the cosmetic composition according to the present invention, is not particularly limited, but is preferably 0.1 to 10: 0.1 to 10: 0.1 to 10: 0.1 to 10, 0.1: 5: 0.1-5: 0.1-5, or 1: 5: 1 to 5: 1 to 5: 1 to 5, and most preferably 1: 1: 1: 1.

In addition, the cosmetic composition according to the present invention can be prepared into a liquid or solid form using a base, an adjuvant or an additive commonly used in the field of cosmetics. Liquid or solid form of cosmetics may include, for example, but not limited to, lotions, creams, lotions, or bath salts. At this time, the bases, adjuvants and additives commonly used in the cosmetics field are not particularly limited and may include, for example, water, alcohol, propylene glycol, stearic acid, glycerol, cetyl alcohol or liquid paraffin.

More specifically, the cosmetic composition of the present invention comprises a centilla extract, timosaponin, hyaluronic acid and collagen as an active ingredient, together with dermatologically acceptable excipients, a basic cosmetic composition (such as lotion, cream, essence, cleansing foam and cleansing water , Packs, body oils), functional cosmetic compositions (anti-wrinkle agents) or soaps. Such excipients include, but are not limited to, for example, emollients, skin penetration enhancers, colorants, fragrances, emulsifiers, thickeners or solvents. In addition, it may further contain a perfume, a coloring agent, a bactericide, an antioxidant, an antiseptic or a moisturizing agent, and may contain an enhancer, an inorganic salt, a synthetic polymer material and the like for the purpose of improving physical properties.

For example, when a cleanser or soap containing timber extract of the present invention, timosaponin, hyaluronic acid and collagen is produced, it can be easily prepared by adding centilla extract, timosaponin, hyaluronic acid and collagen to a common cleanser or soap base have. When a cream is produced, it can be prepared by adding a centilla extract, timosaponin, hyaluronic acid and collagen to a cream base of a typical underwater type (O / W). A synthetic or natural material such as a flavor, a chelating agent, a coloring matter, an antioxidant, an antiseptic, and a protein, a mineral, and a vitamin for the purpose of improving a physical property may be further added.

The amount of the mixture of the centipede extract, timosaponin, hyaluronic acid and collagen is 0.001 to 50.0% by weight, 0.01 to 50.0% by weight, 0.1 to 50.0% by weight, 1 to 50% by weight, To 40% by weight, 1 to 30% by weight, or 1 to 20% by weight.

Hereinafter, the present invention will be described in more detail with reference to Examples. It is to be understood that the scope of the present invention is not limited by these examples in accordance with the gist of the present invention, and it is to be understood by those skilled in the art that the present invention is not limited thereto It will be obvious.

≪ Preparation of Examples and Comparative Examples >

Timosaponin A3 (Wuhan ChemFaces Biochemical CO., Ltd.), Bioland's sodium hyaluronate, Collagen (Ricellap, Collagen Ball), Centella asiatica extract Ltd.) were prepared and prepared in the form of serum in Examples and Comparative Examples in the composition shown in Table 1 below.

EXAMPLES AND COMPARATIVE EXAMPLES Unit: wt% ingredient Example Comparative Example One One 2 3 4 available
ingredient Timosaponin 2.5 2.5 - 2.5 - Hyaluronic acid 2.5 2.5 - 2.5 - Collagen 2.5 - 2.5 2.5 - Centipede extract 2.5 - 2.5 - 2.5 Carbomer 0.5 0.5 0.5 0.5 0.5 Triethanolamine 0.5 0.5 0.5 0.5 0.5 Preservative Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Purified water to 100 to 100 to 100 to 100 to 100

< Experimental Example  >

Experimental Example  1. Skin wrinkle improvement effect

The effect of improving the wrinkles of the skin was measured with respect to each of 23 individuals in Example 1 and Comparative Examples 1 to 4. The test subjects were 25 ~ 35 year old women and applied cosmetics distributed twice a day, morning and evening on the face including the eyes. After 4 weeks, the visiometer SV600 (Courage-Khazaka electronic GmbH, Germany) And R4 representing the skin wrinkle average depth of the wrinkle parameters of R1 to R5 were measured. The average values of the respective test groups tested in Example 1 and Comparative Examples 1 to 4 are shown in Table 2 below. The method of measuring R4 is to integrate the topmost value of the wrinkle profile and the area of the profile and divide by the length of the midline of the profile.

R4 (Wrinkle Average Depth) Average Result Example Comparative Example One One 2 3 4 Before the test 16.08 16.21 16.11 15.98 16.02 After 4 weeks 9.95 13.54 12.78 11.56 14.67 Reduction rate 38.12 16.47 20.67 27.65 8.43

It was calculated according to the Colby method whether the effect of Example 1 is superior to the effects expected from Comparative Examples 1 and 2 and Comparative Examples 3 and 4, and the results are shown in Table 3 below.

Colby method analysis result Judgment element The predicted R4 value of Example 1 Comparative Examples 1 and 2 33.74 Comparative Examples 3 and 4 33.76

As can be seen in Table 3, Example 1 has wrinkle reduction values higher than expected values derived from the Colby method, and the centilla extract, timosaponin, hyaluronic acid, and collagen have a synergistic effect on wrinkle-improving effect .

Experimental Example  2. Skin elasticity enhancement effect

Skin elasticity was measured using a skin elasticity tester (Cutometer SEM 575, C + K Electronic Co., Germany) in order to measure the skin elasticity enhancement effect of the experimental women of Experimental Example 1. Table 4 shows the skin elasticity increase rates of Example 1 and Comparative Examples 1 to 4 using the measurement results before the start of the experiment and the measurement results after the completion of the experiment.

Skin elasticity growth rate (%) Example 1 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 34.45 15.33 17.28 21.48 10.62

It was calculated according to the Colby method whether the effect of Example 1 is superior to the effects expected from Comparative Examples 1 and 2 and Comparative Examples 3 and 4, and the results are shown in Table 5 below.

Colby method analysis result Judgment element The predicted R4 value of Example 1 Comparative Examples 1 and 2 29.96 Comparative Examples 3 and 4 29.82

As can be seen in Table 3, Example 1 has a wrinkle reduction value higher than expected value derived from the Colby method, so that the centilla extract, timosaponin, hyaluronic acid, and collagen have a synergistic effect on skin elasticity .

Claims (5)

An effective ingredient comprising a centella asiatica extract, timosaponin, hyaluronic acid and collagen, a carbomer, a triethanolamine, a preservative, and purified water,
The cosmetic composition for improving skin wrinkles according to claim 1, wherein the active ingredient is a 1: 1: 1: 1 mixture of centistallium extract, timosaponin, hyaluronic acid, and collagen.
delete The method according to claim 1,
Wherein the centilla extract is extracted with at least one extraction solvent selected from the group consisting of water, an anhydrous or hydrated lower alcohol having 1 to 4 carbon atoms, acetone, ethyl acetate, butyl acetate and 1,3-butylene glycol. Composition.
The method according to claim 1,
Wherein the centipede extract, timosaponin, hyaluronic acid, and collagen are contained in an amount of 0.001 to 50.0% by weight based on the total weight of the cosmetic composition.
An effective ingredient comprising a centella asiatica extract, timosaponin, hyaluronic acid and collagen, a carbomer, a triethanolamine, a preservative, and purified water,
Wherein the mixed weight ratio of Centella asiatica extract, Timosaponin, Hyaluronic acid, and Collagen is 1: 1: 1: 1 as the active ingredient.