KR101890854B1 - Cosmetic composition for removing skin keratin having superior moisturizing effect - Google Patents

Abstract

The present invention relates to polyhydroxy acid (PHA); Anti-inflammatory complex; And a natural moisturizing factor. According to the present invention, the skin barrier function can be restored through the exfoliation effect of polyhydroxy acid to maintain a younger and healthier skin. In addition, the skin cosmetic composition for skin exfoliation of the present invention can alleviate the original skin nerve stimulation that can be caused by exfoliation by combination of natural moisturizing factor and anti-inflammatory complex in the skin.

Description

TECHNICAL FIELD [0001] The present invention relates to a cosmetic composition for removing skin exfoliation,

The present invention relates to a cosmetic composition for removing skin exfoliation, and more particularly, to a cosmetic composition for removing skin exfoliation which is excellent in the exfoliation effect by containing polyhydroxy acid (PHA), alleviates irritation to skin, ≪ / RTI >

The most important role of the skin is to prevent heat and water loss from the inside while acting as a defense barrier to protect the skin from external bacterial invasion and damage. The skin consists of several layers, the outermost part of which is called the epidermis, and below it are the dermis and the subcutaneous fat layer.

The epidermis is further subdivided into the stratum corneum, the granular layer, the superficial layer, and the basal layer. The epidermal cells produced in the basal layer take 14 days to reach the granular layer, and the keratinization begins by the action of keratohyalin in the granular layer. The body fluids in the cells have already exited, and the cells have flattened and become keratinized. The nucleus, cytoplasm and organelles of the cell are degenerated, replaced with keratohelinin and changed back to elidin (Eleidin) And the lifetime of the cells is terminated and they are pushed up to the stratum corneum. The stratum corneum is composed of differentiated epidermal cells (keratinocytes) and interstitial cell lipids (Skin Lipids). It protects the body from external substances and protects the body from external physical, chemical and biological stimuli .

The keratinocytes are connected by a protein called desmosomes. As they go up the stratum corneum, the desmosomes decompose and weaken the cohesion between the keratinocytes. Finally, the keratinocytes are separated from the skin and fall off. In normal skin, the stratum corneum is composed of 15-20 layers and it takes 15-20 days to completely separate them. However, as the skin ages, the thickness of skin, dermis, and subcutaneous tissues becomes thinner, the skin's moisture content sharply decreases, and changes in the ECM (Extracellular Matrix) component, which gives skin elasticity, Wrinkles, and the separation of the stratum corneum becomes later than normal, so that the stratum corneum becomes thicker (stratum corneum) and the skin loses its vitality.

Keratinic stratification is mainly caused by decrease of moisture of skin, formation and activity of desmosomal degradation enzyme, and deterioration of cell activity, and causes aging of skin, exposure to ultraviolet rays, and pollution. If the external layer is artificially thinned by external or internal factors, the activity or regeneration of the living cells under the stratum corneum is increased to soften the skin. It is also effective in removing wrinkles, inhibiting the occurrence of acne, There have been a lot of studies to solve the stratum corneum stratification within a range that does not exist.

In order to alleviate the stratum corneum, physically rub the skin or use chemical peeling. Particularly, chemical peeling has additional effects such as improvement of fine wrinkles, rough skin relaxation, and removal of dirt. The substances used for chemical peeling are primarily AHA (Alpha-Hydroxy Acid) and BHA (Beta-Hydroxy Acid).

Among them, α-Hydroxy Acid (AHA) is a compound in which an alcohol group or a hydroxy group is added to a carbon at the α-position of a carboxylic acid, By lowering the binding energy and eliminating the keratin or promoting the formation of new cells, the skin is aged and the period of keratinization process is shortened to promote the activity of the skin cells to improve the skin. It also promotes the production of collagen and elastin by fibroblast to promote skin elasticity and softness and promote the production of mucopolysaccharide, an important extracellular matrix component of the dermis Skin moisturization can be improved. At present, the development of a cosmetic composition for removing skin horny with alpha-hydroxy acid as an active ingredient is actively under development. However, alpha-hydroxy acid is too irritating to the skin and thus has a problem to be used for exfoliation purposes.

On the other hand, polyhydroxy acid (PHA) is an aliphatic compound or an organic carboxylic acid in which two or more hydroxy groups are bonded to an aromatic compound chain. While the alpha hydroxy acid (AHA) contains a hydroxy group at the alpha position, the PHA contains a hydroxy group at various positions including the alpha position. In PHA, the hydroxy group is neutral and the carboxyl group represents the acidity.

The polyhydroxy acid (PHA) as a cosmetic composition lowers the ion binding energy of the keratinocytes of the skin and promotes the formation of new cells, thereby shortening the period of the keratinization process, which is elongated as the skin ages, The effect is greatly increased with an increase in the amount of use. However, since it has disadvantages that it induces skin irritation when used in large amounts on skin, its use in cosmetics is extremely limited.

In addition, skin irritation caused by chemical peeling materials including PHA is not merely a form but a stimulus such as itching, stinging, burning, erythema, edema, And thus there is a problem in that the use thereof is limited and the use of a single anti-inflammatory raw material is not enough to alleviate stimulation.

Under these circumstances, the present inventors have conducted studies on a cosmetic composition in which skin irritation has been alleviated as well as an exfoliation effect, and a combination of a natural moisturizing factor and a anti-inflammatory complex in the skin, To complete the cosmetic composition to be removed.

SUMMARY OF THE INVENTION Accordingly, the present invention has been made to solve the above problems occurring in the prior art, and it is an object of the present invention to provide an exfoliating cosmetic composition containing PHA at a high concentration and alleviating skin irritation for improving the exfoliation.

In order to solve the above problems, the present invention provides a cosmetic composition for removing skin exfoliation comprising polyhydroxy acid (PHA), anti-inflammatory complex and natural moisturizing factor.

Hereinafter, the present invention will be described more specifically.

The polyhydroxy acid refers to the case where a hydroxy group is present at various sites including the alpha position, and may be gluconolactone, riboractone, gluconic acid, lactobionic acid, and the like. Preferably, the polyhydroxy acid may be gluconolactone. Gluconolactone is a kind of acidic polyhydroxyacid (PHA). Because it has a high molecular weight, it has less skin irritation than conventional α-hydroxy acid (AHA) components and can be preserved for a long time. , The skin surface can be maintained in a mildly acidic environment, which is healthy, and the skin barrier function can be restored to maintain a younger and healthier skin.

The polyhydroxy acid (PHA) may be contained in an amount of more than 3 wt%, preferably 3 to 30 wt%, based on the total weight of the composition. When the polyhydroxy acid is contained in an amount of less than 3% by weight, it can not have sufficient exfoliation efficacy, and when it contains more than 30% by weight of polyhydroxy acid, skin irritation may be caused.

The cosmetic composition for removing skin of the skin of the present invention can be used for the skin such as irritation such as itching, stinging and burning caused by chemical peeling material including PHA, erythema, edema etc. Of inflammatory stimuli of the anti-inflammatory complex that serves to mitigate the role is used.

The anti-inflammatory complex essentially comprises a nutmeg extract. Preferably, the anti-inflammatory complex comprises at least one component selected from the group consisting of burdock seed extract, alanyl glutamine, acetyltetapeptide-15, arnica flower extract, algae extract, panthenol, and beta-glucan, But may be, but not limited to, a mixture.

The anti-inflammatory complex may be contained in an amount of 0.5 to 30% by weight, preferably 1.5 to 15% by weight based on the total weight of the composition. When the anti-inflammatory complex is contained in an amount of less than 0.5% by weight, the anti-inflammatory effect is not significant, and irritation occurs largely. If the anti-inflammatory complex is contained in an amount exceeding 30% by weight, the feeling of use may deteriorate or the unit price may increase, .

The cosmetic composition for skin exfoliation of the present invention further comprises a natural moisturizing factor.

Originally, cosmetic materials known to have anti-inflammatory properties have a role in lowering the general irritation, but the effect of lowering the neurosensory irritation test is not known.

The inventors of the present invention have found that by using the anti-inflammatory complex and the natural moisturizing factor together, the stimulant such as itching, stinging, burning, erythema, edema and the like caused by PHA Various inflammatory stimuli and neurosensory irritation test were lowered.

In the present invention, the natural moisturizing factor originates from the filaggrin of the skin and plays a role in maintaining the physical properties of the stratum corneum in the stratum corneum.

The natural moisturizing factor used in the present invention may be at least one selected from the group consisting of urea, amino acid, pyrrolidonecarboxylic acid (PCA), sodium hyaruronate, lactate, glucosamine, potassium ion, sodium ion and calcium ion. But is not limited to.

The natural moisturizing factor may be included in an amount of 0.001 to 10% by weight, preferably 0.01 to 3% by weight based on the total weight of the composition. If the amount of the natural moisturizing factor is less than 0.001% by weight, the effect is insufficient. If the natural moisturizing factor is contained in an amount exceeding 10% by weight, the feeling of use may deteriorate or the unit price may increase greatly.

The cosmetic composition for removing horny skin of the present invention may further comprise a polyol as a moisturizing agent.

The polyol may be at least one selected from the group consisting of glycerin, dipropylene glycol, butylene glycol, pentylene glycol, methylpropanediol, sorbitol, diglycerin, erythritol, pentaerythritol, polybutyleneglycol-10, polyglycerin- 4, polyglycerin-6, polyglycerin-10, polyglycerin-20, polyglycerin-40, sorbes-5, sorbes-6, sorbes-20, sorbes- But are not limited to, maltitol, maltose, mannan, mannitol, mannose, lactitol, lactose, dihydroxypropyl PG-glucoside, dithiaoctanediol, fructose, glucamine, methylglucamine, glucose, , Methylglucose-10, methylglucose-20, ozonized glycerin, phytantriol, thioglycerin, traitol, trimethylol propane, xylitol, etc. may be used alone or in combination of two or more.

The skin cosmetic composition for removing skin of the present invention may further comprise all kinds of ingredients that can be used in ordinary cosmetics such as an ultraviolet screening agent, a neutralizing agent, an aging agent, a flavoring agent, an antiseptic agent, an antioxidant, a pigment and the like.

The skin exfoliating cosmetic composition of the present invention may be prepared in any formulations conventionally produced in the art and may be in the form of, for example, solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, Active-agent-containing cleansing, oils, powder foundations, emulsion foundations, wax foundations and sprays, but are not limited thereto. More specifically, it can be prepared in the form of lotion, lotion, nutritional cream, massage cream, essence, eye cream, cleansing cream, cleansing foam, cleansing water, pack, spray or powder.

According to the present invention, the skin barrier function can be restored through the exfoliation effect of polyhydroxy acid to maintain a younger and healthier skin. In addition, the skin cosmetic composition for skin exfoliation of the present invention can alleviate the original skin nerve stimulation that can be caused by exfoliation by combination of natural moisturizing factor and anti-inflammatory complex in the skin.

Figure 1 shows the results of the first order irritation test.
Figure 2 shows the results of the primary Neurosensory irritation test.
3 shows the results of the second order irritation test.
Figure 4 shows the results of the second-order neurosensory irritation test.
Figure 5 shows the results of the third-order neurosensory irritation test.
Figure 6 shows the exfoliation efficacy.
Fig. 7 shows the skin texture improving effect.

Hereinafter, the present invention will be described in more detail with reference to the following examples. These examples are for illustrative purposes only, and the scope of the present invention is not limited to these examples.

Examples 1 and 2: Preparation of compositions for exfoliating

The composition for exfoliating in Examples 1 and 2 was prepared with the composition shown in Table 1 below.

Specifically, glucono-delta lactone, panthenol, nutmeg extract, and urea were added to purified water, stirred to obtain a homogeneous phase, and then neutralized, thickener, polyol and preservative were added thereto and stirred well to form a homogeneous phase.

Comparative Example 1: Preparation of composition for exfoliating

A composition for exfoliating the skin was prepared in the same manner as in Example 1, except that the nutmeg extract and the urea were not used.

Comparative Example 2: Preparation of composition for exfoliating

The composition for exfoliating was prepared in the same manner as in Example 1, except that urea was not used.

Comparative Example 3 (Control group): Preparation of composition for exfoliating

A composition for exfoliating the skin was prepared in the same manner as in Example 1, except that glucono delta lactone, nutmeg extract, and urea were not used.

Composition (% by weight) Example 1 Example 2 Comparative Example 1 Comparative Example 2 Comparative Example 3 Purified water To100 To100 To100 To100 To100 Glucono delta lactone 5 to 10 5 to 10 5 to 10 5 to 10 - Tromethamine Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Xanthan gum 0.3 0.3 0.3 0.3 0.3 Propanediol 7 7 7 7 7 Phenoxyethanol 0.5 0.5 0.5 0.5 0.5 Panthenol One One One One One Nutmeg extract 0.5 0.5 0.5 Urea 0.1 0.01

Experimental Example 1. Evaluation of stimulus

Skin irritation tests and neurosensory irritation tests were performed on the products prepared with the compositions of Examples 1 and 2 and Comparative Examples 1 to 3 under the following conditions.

[Exam conditions]

1) Test site: Elbow Flex (antecubital fossa: Jujeonwa)

2) Test area: 5cm x 5cm

3) Number of applications: 2 times / day (morning and afternoon)

4) Application amount: 20 ~ 30mg / one time

5) Application period: 1 week (7 days)

6) Removal of test material: Washing

7) Reading time: Reading before application in the morning

The irritation test was evaluated by the expert 's visual evaluation and rated irritation directly on the skin by scoring with None / Doubtful / Weak / Moderate / Strong.

Neurosensory irritation test is a method of evaluating the sting, itching, and burning sensations experienced by the respondents as follows: ≤ 0.3: non-sting / itching / 0.3 <S ≤ 1.0: slight sting / itching, 1.0 < ≤ 2.0: moderate sting / itching / 2.0 <: severe sting / itching.

[Test result]

<Primary Irritation test result>

Figure 1 shows the results of the first order irritation test. As a result of the evaluation of the irritation of the composition of Comparative Example 1, the degree of the irritation reaction was a general level, and there was no irritating level of concern but it showed slight irritation rise on the 3rd to 4th day. Compared with Comparative Example 3 (control group), there was no stimulation at the level of concern.

<Results of primary neurosensory irritation test>

Figure 2 shows the results of the primary Neurosensory irritation test. The composition of Comparative Example 1 exhibited slight stinging / itching / burning potential during the whole period of the experiment and showed weak nerve stimulation symptoms. The composition of Comparative Example 1 contained an AHA derivative and expected to have some nerve stimulation symptoms. In the case of the composition of Comparative Example 1, the possibility of occurrence of troubles due to nerve stimulation is expected, which is not suitable as a product.

<Secondary Irritation test result>

3 shows the results of the second order irritation test. As a result of the evaluation of the irritation of the composition of Comparative Example 2, the degree of the irritation reaction was a general level, and there was no irritation level at a worrisome level, but a slight increase in irritation was observed at 2 to 3 days. Compared with Comparative Example 3, no stimulation was observed at a level of concern.

<Second Neurosensory irritation test result>

Figure 4 shows the results of the second-order neurosensory irritation test. The composition of Comparative Example 2 exhibited slight stinging / itching / burning potential only on the first day of application, followed by non-stinging / itching / burning potential. Compared with Comparative Example 1, mild tendency was shown in comparison with nerve stimulation symptoms. In the case of Comparative Example 3, there was no nerve stimulation symptom to be worried during the whole period of the experiment, and non-stinging / itching / burning potential was shown.

<Third Neurosensory irritation test result>

Figure 5 shows the results of the third-order neurosensory irritation test. The composition of Example 2 exhibited slight stinging / itching potential only on day 2, and the composition of Example 1 showed no-stinging / itching potential at the worst level of nerve stimulation during the entire application period.

Experimental Example 2. Evaluation of the degree of improvement of horny layer and evaluation of transparency of skin texture

[Outline of examination]

The skin care products of Example 1 (product A) and Example 2 (product B) were applied to the facial part of five subjects and the degree of improvement of the skin was evaluated. The skin texture, transparency Evaluation was also conducted.

[Test result]

&Lt; Evaluation result of the degree of improvement of the horny &

Figure 6 shows the exfoliation efficacy. Example 1 (product A) showed significant improvement in skin texture immediately after use, and no significant improvement was observed at other times. Example 2 (product B) showed a tendency to improve the keratinolysis, except for only one subject in five subjects at all time points 2 days and 7 days immediately afterwards (only 3 out of 5 persons in the case of product A)

&Lt; Evaluation results of skin-improving effect >

Fig. 7 shows the skin texture improving effect. The skin texture of Example 1 (Product A) was improved by about 3.66% after use of the product, and 4 of 5 patients showed improvement of skin texture, and Product A is considered to help improve skin texture.

The composition of Comparative Example 1, which did not use nutmeg extract and urea, showed high nerve stimulation, and the composition of Comparative Example 2, which did not use urea, alleviated the nerve stimulation but still provoked stimulation.

On the other hand, it was confirmed that the compositions of Examples 1 and 2 including PHA, anti-inflammatory complex and natural moisturizing factor can be used as a product after nerve stimulation is alleviated at the time of use.

Thus, it has been confirmed that when the anti-inflammatory complex and the natural moisturizing factor are used together with PHA according to the present invention, it is possible to provide an exfoliating cosmetic composition excellent in nerve stimulation relaxation and moisturizing retention.

Claims (8)

Gluconolactone as an exfoliating substance; Selected from the group consisting of burdock seed extract, alanyl glutamine, acetyltetrapeptide-15, arnica flower extract, algae extract, panthenol, and beta-glucan in combination with nutmeg extract to alleviate skin nerve stimulation symptoms by gluconolactone And at least one natural moisturizing agent selected from the group consisting of urea, amino acid, pyrrolidonecarboxylic acid (PCA), sodium hyaruronate, lactate, glucosamine, potassium ion, sodium ion and calcium ion Wherein the cosmetic composition contains an anti-inflammatory agent. delete The cosmetic composition according to claim 1, wherein the gluconolactone is contained in an amount of 3 to 30% by weight based on the total weight of the composition. delete The cosmetic composition according to claim 1, wherein the anti-inflammatory complex is contained in an amount of 0.5 to 30% by weight based on the total weight of the composition. delete The cosmetic composition according to claim 1, wherein the natural moisturizing factor is contained in an amount of 0.001 to 10% by weight based on the total weight of the composition. The cosmetic composition according to claim 1, wherein the cosmetic composition for removing skin exfoliation further comprises a polyol as a moisturizing agent.

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